tyrphostin-ag825 has been researched along with o-iodoxybenzoic-acid* in 1 studies
1 other study(ies) available for tyrphostin-ag825 and o-iodoxybenzoic-acid
| Article | Year |
|---|---|
Neuregulin-1 isoform induces mitogenesis, KCa and Ca2+ currents in PC12 cells. A comparison with sciatic nerve conditioned medium.
Neuregulin-1 (NRG-1) is an active component found in sciatic nerve conditioned medium (CM). NRG-1 is a growth and differentiation factor shown to have an effect on neuritogenesis and survival of neural cells. PC12 cells chronically treated with NRG-1 (beta1 isoform) show an increase in proliferation under low-serum condition (2.5% fetal bovine serum and 1.25% horse serum) and serum deprivation, without visible morphological changes. NRG-1 and CM treatments of PC12 cells induced an increase of voltage-activated Ca2+ currents and large-conductance calcium-activated K+ currents (KCa). AG825, a specific inhibitor for erbB2 receptor, abolishes KCa current, though Ca2+ currents were not inhibited. These results showed that NRG-1 is capable of inducing functional changes but is not sufficient on its own to have an effect on cell morphology. Topics: Analysis of Variance; Animals; Benzothiazoles; Calcium Channels; Cell Differentiation; Cell Proliferation; Charybdotoxin; Culture Media, Conditioned; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glycoproteins; Humans; Iodobenzenes; Neuregulin-1; Neurotoxins; Patch-Clamp Techniques; PC12 Cells; Potassium Channels, Calcium-Activated; Protein Isoforms; Rats; Receptor, ErbB-2; Sciatic Nerve; Tyrphostins | 2006 |