tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine has been researched along with enkephalin, leucine in 19 studies
| Studies (tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine) | Trials (tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine) | Recent Studies (post-2010) (tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine) | Studies (enkephalin, leucine) | Trials (enkephalin, leucine) | Recent Studies (post-2010) (enkephalin, leucine) |
|---|---|---|---|---|---|
| 25 | 0 | 0 | 11,524 | 80 | 754 |
| Protein | Taxonomy | tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine (IC50) | enkephalin, leucine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0142 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0417 | |
| Mu-type opioid receptor | Homo sapiens (human) | 9.5 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0308 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.246 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 12 (63.16) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Witte, P; Gewiss, M; Heidbreder, C; Lallemand, S; Roques, BP | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Drukarch, B; Mulder, AH; Ruuls, SR; Schoffelmeer, AN; Van Vliet, BJ | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN; Warden, G | 1 |
| Burks, TF; Davis, P; Haaseth, RC; Hruby, VJ; Kramer, TH; Matsunaga, TO; Toth, G | 1 |
| Schoffelmeer, AN; Simon, EJ; Yao, YH | 2 |
| Feger, J; Maldonado, R; Roques, BP; Waksman, G | 1 |
| Gioannini, TL; Hiller, JM; Ofri, D; Roques, BP; Schoffelmeer, AN; Simon, EJ; Yao, YH | 1 |
| Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Dickenson, AH; Magnuson, DS; Roques, BP; Simonnet, G; Sullivan, AF | 1 |
| Belleney, J; Fournié-Zaluski, MC; Gacel, G; Maigret, B; Roques, BP | 1 |
| Dickenson, AH; Roques, BP; Sullivan, AF | 1 |
| De Vries, TJ; Delay-Goyet, P; Mulder, AH; Roques, BP; Schoffelmeer, AN | 1 |
| Calenco, G; Daugé, V; Delay-Goyet, P; Gacel, G; Morgat, JL; Roques, BP; Seguin, C | 1 |
| Delay-Goyet, P; Gacel, G; Roques, BP; Seguin, C | 1 |
| Breuzé, P; Daugé, V; Delay-Goyet, P; Gacel, G; Roques, BP | 1 |
| Mulder, AH; Ronken, E; Schoffelmeer, AN | 1 |
| Bruetschy, L; Gacel, GA; Guis, C; Meudal, H; Roques, BP | 1 |
19 other study(ies) available for tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine and enkephalin, leucine
| Article | Year |
|---|---|
Inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon.
Topics: Animals; Brain; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mesencephalon; Motor Activity; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward; Self Stimulation | 1992 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Beta-adrenoceptor-sensitive adenylate cyclase is inhibited by activation of mu-opioid receptors in rat striatal neurons.
Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoproterenol; Male; Naloxone; Neuroglia; Neurons; Norepinephrine; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Beta-endorphin: a highly selective endogenous opioid agonist for presynaptic mu opioid receptors.
Topics: Animals; beta-Endorphin; Brain; Culture Techniques; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Neurotransmitter Agents; Norepinephrine; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro.
Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1991 |
Cross-linking of 125I-beta-endorphin to rat striatal mu- and delta-opioid receptors under physiological conditions: evidence for an opioid receptor complex.
Topics: Animals; beta-Endorphin; Binding, Competitive; Corpus Striatum; Cross-Linking Reagents; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Iodine Radioisotopes; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Naloxone-induced withdrawal syndrome after administration of selective opioid agonists or after activation of the endogenous enkephalinergic system.
Topics: Animals; Behavior, Animal; Body Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Weight Loss | 1990 |
Cross-linking of human [125I]beta-endorphin to opioid receptors in rat striatal membranes: biochemical evidence for the existence of a mu/delta opioid receptor complex.
Topics: Animals; beta-Endorphin; Binding Sites; Cattle; Cerebral Cortex; Corpus Striatum; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Oligopeptides; Proteins; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors.
Topics: Animals; Cerebral Ventricles; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; Injections, Intraventricular; Male; Naloxone; Neprilysin; Oligopeptides; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reference Values; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Differential interactions of cholecystokinin and FLFQPQRF-NH2 with mu and delta opioid antinociception in the rat spinal cord.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Injections, Spinal; Male; Nerve Fibers; Neurons; Oligopeptides; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide; Spinal Cord | 1990 |
Cross-linking of human 125I-beta-endorphin to a mu-delta opioid receptor complex in rat striatum.
Topics: Animals; beta-Endorphin; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Iodine Radioisotopes; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1989 |
Delta opioid receptor selectivity induced by conformational constraints in linear enkephalin-related peptides: 1H 400-MHz NMR study and theoretical calculations.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry; Dimethyl Sulfoxide; Enkephalin, Leucine; Enkephalins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Protein Binding; Protein Conformation; Receptors, Opioid; Temperature | 1989 |
Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones.
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Evoked Potentials; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Selective effects of [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 (O-t-butyl), two new enkephalin analogues, on neurotransmitter release and adenylate cyclase in rat brain slices.
Topics: Adenylyl Cyclases; Alkylating Agents; Animals; Brain; Corpus Striatum; Cyclic AMP; Dopamine; Electric Stimulation; Enkephalins; Fentanyl; Isothiocyanates; Male; Neurotransmitter Agents; Oligopeptides; Rats; Rats, Inbred Strains | 1989 |
[3H]DSTBULET, a new linear hexapeptide with both an improved selectivity and a high affinity for delta-opioid receptors.
Topics: Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1986 |
[3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Kinetics; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mice; Oligopeptides; Protein Conformation; Receptors, Opioid; Receptors, Opioid, delta | 1988 |
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes | 1993 |
Investigation of the structural parameters involved in the delta-opioid selectivity of several families of opioid peptides.
Topics: Amino Acid Sequence; Amino Acids; Animals; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Molecular Sequence Data; Oligopeptides; Rats; Receptors, Opioid, delta | 1993 |