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tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) and enkephalin, leucine

tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) has been researched along with enkephalin, leucine in 12 studies

Compound Research Comparison

Studies
(tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl))
Trials
(tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl))
Recent Studies (post-2010)
(tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl))
Studies
(enkephalin, leucine)
Trials
(enkephalin, leucine)
Recent Studies (post-2010) (enkephalin, leucine)
150011,52480754

Protein Interaction Comparison

ProteinTaxonomytyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) (IC50)enkephalin, leucine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.0142
Kappa-type opioid receptorMus musculus (house mouse)0.0417
Mu-type opioid receptorHomo sapiens (human)9.5
Mu-type opioid receptorMus musculus (house mouse)0.0308
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.246

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's11 (91.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Roques, BP1
Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP1
Calenco-Choukroun, G; Daugé, V; Gacel, G; Roques, BP1
Baamonde, A; Delay-Goyet, P; Gacel, G; Morgat, JL; Roques, BP; Ruiz-Gayo, M1
Baamonde, A; Daugé, V; Gacel, G; Roques, BP1
De Vries, TJ; Delay-Goyet, P; Mulder, AH; Roques, BP; Schoffelmeer, AN1
Noble, F; Roques, BP; Smadja, C1
Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP1
Desmeules, JA; Guilbaud, G; Kayser, V1
Derrien, M; Noble, F; Roques, BP1
Fournie-Zaluski, MC; Noble, F; Roques, BP1
Gilbert-Rahola, J; Maldonado, R; Micó, JA; Roques, BP; Smadja, C; Tejedor-Real, P1

Other Studies

12 other study(ies) available for tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) and enkephalin, leucine

ArticleYear
Peptidomimetics as receptors agonists or peptidase inhibitors: a structural approach in the field of enkephalins, ANP and CCK.
    Biopolymers, 1992, Volume: 32, Issue:4

    Topics: Amino Acid Sequence; Atrial Natriuretic Factor; Cholecystokinin; Enkephalins; Models, Molecular; Molecular Sequence Data; Oligopeptides; Peptides; Protease Inhibitors; Receptors, Cell Surface

1992
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
    Psychopharmacology, 1991, Volume: 103, Issue:4

    Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali

1991
Lesion of dopamine mesolimbic neurons blocks behavioral effects induced by the endogenous enkephalins but not by a mu-opioid receptor agonist.
    European journal of pharmacology, 1991, Dec-17, Volume: 209, Issue:3

    Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Dipeptides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Molecular Sequence Data; Motor Activity; Neurons; Nucleus Accumbens; Oligopeptides; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali

1991
Brain passage of BUBU, a highly selective and potent agonist for delta opioid receptors: in vivo binding and mu versus delta receptors occupancy.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Kinetics; Male; Mice; Motor Activity; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1991
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:2

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu

1991
Selective effects of [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 (O-t-butyl), two new enkephalin analogues, on neurotransmitter release and adenylate cyclase in rat brain slices.
    European journal of pharmacology, 1989, Nov-07, Volume: 170, Issue:3

    Topics: Adenylyl Cyclases; Alkylating Agents; Animals; Brain; Corpus Striatum; Cyclic AMP; Dopamine; Electric Stimulation; Enkephalins; Fentanyl; Isothiocyanates; Male; Neurotransmitter Agents; Oligopeptides; Rats; Rats, Inbred Strains

1989
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide

1994
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal

1993
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
    Pain, 1993, Volume: 53, Issue:3

    Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal

1993
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
    British journal of pharmacology, 1993, Volume: 109, Issue:4

    Topics: Amino Acid Sequence; Analgesics; Animals; Cholecystokinin; Disulfides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Oligopeptides; Pain; Pain Measurement; Peptide Fragments; Phenylalanine; Sincalide; Spinal Cord

1993
Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity.
    Neuroscience, 1996, Volume: 75, Issue:3

    Topics: Adenylyl Cyclases; Analgesics; Animals; Caudate Nucleus; Cholecystokinin; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Mice, Inbred Strains; Oligopeptides; Putamen; Receptors, Opioid, delta

1996
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model.
    European journal of pharmacology, 1998, Jul-31, Volume: 354, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta

1998