tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) has been researched along with enkephalin, leucine in 12 studies
| Studies (tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl)) | Trials (tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl)) | Recent Studies (post-2010) (tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl)) | Studies (enkephalin, leucine) | Trials (enkephalin, leucine) | Recent Studies (post-2010) (enkephalin, leucine) |
|---|---|---|---|---|---|
| 15 | 0 | 0 | 11,524 | 80 | 754 |
| Protein | Taxonomy | tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) (IC50) | enkephalin, leucine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0142 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0417 | |
| Mu-type opioid receptor | Homo sapiens (human) | 9.5 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0308 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.246 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 11 (91.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roques, BP | 1 |
| Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP | 1 |
| Calenco-Choukroun, G; Daugé, V; Gacel, G; Roques, BP | 1 |
| Baamonde, A; Delay-Goyet, P; Gacel, G; Morgat, JL; Roques, BP; Ruiz-Gayo, M | 1 |
| Baamonde, A; Daugé, V; Gacel, G; Roques, BP | 1 |
| De Vries, TJ; Delay-Goyet, P; Mulder, AH; Roques, BP; Schoffelmeer, AN | 1 |
| Noble, F; Roques, BP; Smadja, C | 1 |
| Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Derrien, M; Noble, F; Roques, BP | 1 |
| Fournie-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Gilbert-Rahola, J; Maldonado, R; Micó, JA; Roques, BP; Smadja, C; Tejedor-Real, P | 1 |
12 other study(ies) available for tyrosyl-seryl(o-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(o-t-butyl) and enkephalin, leucine
| Article | Year |
|---|---|
Peptidomimetics as receptors agonists or peptidase inhibitors: a structural approach in the field of enkephalins, ANP and CCK.
Topics: Amino Acid Sequence; Atrial Natriuretic Factor; Cholecystokinin; Enkephalins; Models, Molecular; Molecular Sequence Data; Oligopeptides; Peptides; Protease Inhibitors; Receptors, Cell Surface | 1992 |
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Lesion of dopamine mesolimbic neurons blocks behavioral effects induced by the endogenous enkephalins but not by a mu-opioid receptor agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Dipeptides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Limbic System; Male; Molecular Sequence Data; Motor Activity; Neurons; Nucleus Accumbens; Oligopeptides; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali | 1991 |
Brain passage of BUBU, a highly selective and potent agonist for delta opioid receptors: in vivo binding and mu versus delta receptors occupancy.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Kinetics; Male; Mice; Motor Activity; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1991 |
Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indoles; Injections, Intravenous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Selective effects of [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-t-butyl),Leu5]enkephalyl-Thr6 (O-t-butyl), two new enkephalin analogues, on neurotransmitter release and adenylate cyclase in rat brain slices.
Topics: Adenylyl Cyclases; Alkylating Agents; Animals; Brain; Corpus Striatum; Cyclic AMP; Dopamine; Electric Stimulation; Enkephalins; Fentanyl; Isothiocyanates; Male; Neurotransmitter Agents; Oligopeptides; Rats; Rats, Inbred Strains | 1989 |
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
Topics: Amino Acid Sequence; Analgesia; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Disulfides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Molecular Sequence Data; Naloxone; Naltrexone; Oligopeptides; Peptide Fragments; Phenylalanine; Receptors, Opioid, delta; Receptors, Opioid, mu; Sincalide | 1994 |
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
Topics: Amino Acid Sequence; Analgesics; Animals; Cholecystokinin; Disulfides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Oligopeptides; Pain; Pain Measurement; Peptide Fragments; Phenylalanine; Sincalide; Spinal Cord | 1993 |
Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity.
Topics: Adenylyl Cyclases; Analgesics; Animals; Caudate Nucleus; Cholecystokinin; Dose-Response Relationship, Drug; Enkephalins; Male; Mice; Mice, Inbred Strains; Oligopeptides; Putamen; Receptors, Opioid, delta | 1996 |
Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model.
Topics: Analgesics; Animals; Behavior, Animal; Disulfides; Drug Interactions; Enkephalins; Helplessness, Learned; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Phenylalanine; Rats; Rats, Wistar; Receptors, Opioid, delta | 1998 |