tyrosyl-prolyl-tryptophyl-glycinamide has been researched along with naloxone in 6 studies
| Studies (tyrosyl-prolyl-tryptophyl-glycinamide) | Trials (tyrosyl-prolyl-tryptophyl-glycinamide) | Recent Studies (post-2010) (tyrosyl-prolyl-tryptophyl-glycinamide) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 25 | 0 | 0 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | tyrosyl-prolyl-tryptophyl-glycinamide (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruno, C; Hackler, L; Kastin, AJ; Kenigs, V; Zadina, JE | 1 |
| Gergen, KA; Kastin, AJ; Paul, D; Zadina, JE | 1 |
| Gergen, KA; Paul, D; Zadina, JE | 1 |
| Harrison, LM; Kastin, AJ; Zadina, JE | 1 |
| Fujimura, T; Ito, K; Kawamura, S; Mizoguchi, H; Murayama, K; Nakayama, D; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, C; Watanabe, H | 1 |
| Mizoguchi, H; Nakayama, D; Sakurada, S; Sakurada, T; Watanabe, C; Watanabe, H | 1 |
6 other study(ies) available for tyrosyl-prolyl-tryptophyl-glycinamide and naloxone
| Article | Year |
|---|---|
Prolonged analgesia after intracerebroventricular Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2).
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Injections, Intraventricular; Male; Molecular Sequence Data; Motor Activity; MSH Release-Inhibiting Hormone; Naloxone; Pain; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Desipramine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-2; Yohimbine | 1996 |
Analgesic effects of Tyr-W-MIF-1: a mixed mu2-opioid receptor agonist/mu1-opioid receptor antagonist.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Narcotics; Pain Measurement; Receptors, Opioid, mu | 1996 |
Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells.
Topics: Culture Media; Down-Regulation; Endorphins; Enkephalin, Methionine; Humans; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Up-Regulation | 1998 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hot Temperature; Injections, Intraventricular; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Opioid, mu; Somatostatin; Time Factors | 2007 |