tyrosyl-prolyl-leucyl-glycinamide has been researched along with naloxone in 19 studies
| Studies (tyrosyl-prolyl-leucyl-glycinamide) | Trials (tyrosyl-prolyl-leucyl-glycinamide) | Recent Studies (post-2010) (tyrosyl-prolyl-leucyl-glycinamide) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 109 | 0 | 0 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | tyrosyl-prolyl-leucyl-glycinamide (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Krowicki, ZK | 2 |
| Kastin, AJ; Miller, LG; Schwartzenburg, DS | 1 |
| Kastin, AJ; Miller, LG; Olson, GA; Olson, RD; Schwartzenburg, D; Tsui, L | 1 |
| Chi, DS; Kastin, AJ; Strimas, JH | 1 |
| Galina, ZH; Kastin, AJ | 3 |
| Kastin, AJ; Zadina, JE | 1 |
| Banks, WA; Kastin, AJ; Nager, BJ | 1 |
| Kastin, AJ; Pulvirenti, L | 1 |
| Ehrensing, RH; Fischman, AJ; Kastin, AJ; Stephens, E | 1 |
| Hagan, MM; Moss, DE | 1 |
| Chang, SL; Ge, LJ; Kastin, AJ; Zadina, JE | 1 |
| Benyhe, S; Borsodi, A; Magyar, A; Medzihradszky, K; Rónai, AZ; Sartania, N | 1 |
| Bocheva, A; Georgieva, M; Golovinsky, E; Pajpanova, T; Todorov, S; Zamfirova, R | 1 |
| d'Amore, A; Loizzo, A | 1 |
| Bocheva, A; Todorov, S; Zamfirova, R | 1 |
1 review(s) available for tyrosyl-prolyl-leucyl-glycinamide and naloxone
| Article | Year |
|---|---|
Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1.
Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hypothalamus; Kinetics; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Receptors, Opioid | 1986 |
18 other study(ies) available for tyrosyl-prolyl-leucyl-glycinamide and naloxone
| Article | Year |
|---|---|
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Cimetidine does not change the effect of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on the opiate form of footshock-induced analgesia.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Chlorpheniramine; Cimetidine; Electroshock; Male; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Pain; Pain Measurement; Rats; Rats, Inbred Strains | 1991 |
Dopamine receptor antagonists block the effect of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on the opiate form of footshock-induced analgesia.
Topics: Amino Acid Sequence; Animals; Benzazepines; Dopamine Antagonists; Drug Synergism; Foot; Haloperidol; Hot Temperature; Male; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Transcutaneous Electric Nerve Stimulation | 1991 |
MIF-1 and Tyr-MIF-1 fail to alter benzodiazepine-induced hypothermia.
Topics: Animals; Anti-Anxiety Agents; Body Temperature; Chlordiazepoxide; Drug Interactions; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred ICR; MSH Release-Inhibiting Hormone; Naloxone | 1989 |
Differential effects of Tyr-MIF-1 and naloxone in two animal models involving benzodiazepine.
Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Feeding Behavior; Male; Mice; Mice, Inbred ICR; Motor Activity; MSH Release-Inhibiting Hormone; Naloxone; Receptors, GABA-A | 1989 |
In vitro studies of Tyr-MIF-1 with human lymphocytes.
Topics: Antigens, CD; Cell Division; Concanavalin A; Humans; In Vitro Techniques; Lymphocytes; Morphine; MSH Release-Inhibiting Hormone; Naloxone | 1989 |
Interactions of Tyr-MIF-1 at opiate receptor sites.
Topics: Animals; Binding, Competitive; Brain; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Tyr-MIF-1 attenuates antinociceptive responses induced by three models of stress-analgesia.
Topics: Analgesia; Analgesics; Analysis of Variance; Animals; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Stress, Physiological | 1987 |
Analgesia and the blood-brain barrier transport system for Tyr-MIF-1/enkephalins: evidence for a dissociation.
Topics: Animals; Blood-Brain Barrier; Enkephalins; Food Deprivation; Male; Mice; Mice, Inbred ICR; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Pain; Restraint, Physical; Stereoisomerism; Stress, Physiological; Time Factors; Water Deprivation | 1988 |
Differential activity of the endogenous antiopiate Tyr-MIF-1 after various intensities of stress.
Topics: Analgesia; Animals; Electroshock; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Physical Exertion; Stress, Psychological | 1988 |
Naloxone, but not Tyr-MIF-1, reduces volitional ethanol drinking in rats: correlation with degree of spontaneous preference.
Topics: Alcohol Drinking; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Male; MSH Release-Inhibiting Hormone; Naloxone; Rats; Statistics as Topic | 1988 |
Tyr-MIF-1 acts as an opiate antagonist in the tail-flick test.
Topics: Animals; Hot Temperature; Male; Mice; Mice, Inbred ICR; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Pain | 1984 |
Differential effects of Tyr-MIF-1, MIF-1, and naloxone on peptide YY-induced hyperphagia.
Topics: Animals; Behavior, Animal; Feeding Behavior; Hyperphagia; Male; MSH Release-Inhibiting Hormone; Naloxone; Peptide YY; Peptides; Rats; Rats, Sprague-Dawley | 1994 |
Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells.
Topics: Amino Acid Sequence; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Humans; Kinetics; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Naloxone; Neuroblastoma; Pentazocine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Receptors, Opioid, mu; Temperature; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1993 |
Opioid binding profile of morphiceptin, Tyr-MIF-1 and dynorphin-related peptides in rat brain membranes.
Topics: Analgesics; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dynorphins; Endorphins; Guinea Pigs; Ileum; Male; MSH Release-Inhibiting Hormone; Muscles; Naloxone; Narcotic Antagonists; Oligopeptides; Opioid Peptides; Radioligand Assay; Rats; Receptors, Opioid; Structure-Activity Relationship; Tritium | 1996 |
Effect of diphenylhydramine on the Tyr-MIF-1 antinociception in rats.
Topics: Analgesics; Animals; Diphenhydramine; Drug Combinations; Hindlimb; Histamine H1 Antagonists; Hot Temperature; Injections, Intraperitoneal; Male; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Tail | 1998 |
Effects of neonatal treatment with Tyr-MIF-1 and naloxone on the long-term body weight gain induced by repeated postnatal stressful stimuli.
Topics: Adipose Tissue; Animals; Animals, Newborn; Eating; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Narcotic Antagonists; Opioid Peptides; Stress, Physiological; Weight Gain | 1999 |
Involvement of H2-receptors in the mechanism of analgesic action of Tyr-MIF-1.
Topics: Analgesics; Animals; Cimetidine; Dimaprit; Disease Models, Animal; Injections, Intraperitoneal; MSH Release-Inhibiting Hormone; Naloxone; Nociceptors; Pain Measurement; Pressure; Rats; Receptors, Histamine H2; Reflex | 2003 |