tyrosyl-arginyl-phenylalanyl-lysinamide has been researched along with naloxone in 12 studies
| Studies (tyrosyl-arginyl-phenylalanyl-lysinamide) | Trials (tyrosyl-arginyl-phenylalanyl-lysinamide) | Recent Studies (post-2010) (tyrosyl-arginyl-phenylalanyl-lysinamide) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 74 | 0 | 17 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | tyrosyl-arginyl-phenylalanyl-lysinamide (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boura, AL; Callaway, JK; King, RG | 1 |
| Krylatov, AV; Lishmanov, IuB; Maslov, LN | 1 |
| Clapp, JF; Kett, A; Kim, H; Olariu, N; Omoniyi, AT; Szeto, HH; Wu, D | 1 |
| Holsey, YS; Omoniyi, AT; Soong, Y; Szeto, HH; Wu, D | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Clapp, JF; Kett, A; Omoniyi, AT; Soong, Y; Szeto, HH; Wu, D | 1 |
| Schiller, PW; Shimoyama, M; Shimoyama, N; Szeto, HH; Zhao, GM | 1 |
| Neilan, CL; Nguyen, TM; Pasternak, GW; Schiller, PW | 1 |
| Ben, Y; Furst, S; Lee, NM; Nguyen, TM; Riba, P; Schiller, PW | 1 |
| Bogomaz, SA; Gross, GJ; Krylatov, AV; Lishmanov, AIu; Loktiushina, BA; Maslov, LN; Naryzhaia, NV; Solenkova, NV; Stefano, JB | 1 |
| Brun, V; Chuoï-Mariot, MT; Colombel, JF; Desreumaux, P; Dubuquoy, L; Gaveriaux-Ruff, C; Groux, H; Kieffer, BL; Philippe, D | 1 |
| Holloway, AC; Nurse, CA; Salman, S | 1 |
12 other study(ies) available for tyrosyl-arginyl-phenylalanyl-lysinamide and naloxone
| Article | Year |
|---|---|
Evidence for peripheral mechanisms mediating the antitussive actions of opioids in the guinea pig.
Topics: Administration, Inhalation; Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Dextromethorphan; Female; Guinea Pigs; Injections, Intraperitoneal; Morphine; Naloxone; Narcotics; Oligopeptides; Oxymorphone; Peripheral Nerves | 1991 |
[The anti-arrhythmic effect of the mu-opiate receptor agonists in adrenal arrhythmia: the role of the autonomic nervous system].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Autonomic Nervous System; Electrocardiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Ganglionic Blockers; Hexamethonium; Male; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu | 1996 |
Baroreflex-mediated bradycardia but not tachycardia is blunted peripherally by intravenous mu-opioid agonists.
Topics: Animals; Baroreflex; Blood Pressure; Bradycardia; Female; Heart Rate; Naloxone; Nitroprusside; Norepinephrine; Oligopeptides; Pregnancy; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Sheep; Tachycardia | 1998 |
Cardiovascular effects of a mu-selective opioid agonist (tyrosine-D-arginine-phenylalanine-lysine-NH2) in fetal sheep: sites and mechanisms of action.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiovascular System; Female; Heart Rate, Fetal; Kinetics; Naloxone; Narcotic Antagonists; Oligopeptides; Pregnancy; Propranolol; Receptors, Opioid, mu; Sheep | 1999 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
A peripheral site of action for the attenuation of baroflex-mediated bradycardia by intravenous mu-opioid agonists.
Topics: Animals; Anti-Arrhythmia Agents; Baroreflex; Bradycardia; Catheters, Indwelling; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Naloxone; Narcotic Antagonists; Nitroprusside; Norepinephrine; Oligopeptides; Pregnancy; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Sheep | 2000 |
Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naloxone; Norepinephrine; Oligopeptides; Rats; Rats, Sprague-Dawley; Respiration; Serotonin; Yohimbine | 2001 |
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2001 |
[Dmt(1)]DALDA is highly selective and potent at mu opioid receptors, but is not cross-tolerant with systemic morphine.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, mu; Spinal Cord; Time Factors | 2002 |
[Interactions of peripheral mu-opioid receptors and K(ATP)-channels in regulation of cardiac electrical stability in ischemia, reperfusion, and postinfarction cardiosclerosis].
Topics: Animals; Electrocardiography; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Naloxone; Oligopeptides; Peptide Fragments; Peptides; Potassium Channels; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, mu; Sclerosis; Somatostatin | 2002 |
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Colitis; Colon; Cytokines; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Naloxone; Narcotic Antagonists; Oligopeptides; Peroxidase; Receptors, Opioid, mu; Trinitrobenzenesulfonic Acid | 2003 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2014 |