tyrosyl-arginyl-phenylalanyl-lysinamide has been researched along with morphine in 12 studies
| Studies (tyrosyl-arginyl-phenylalanyl-lysinamide) | Trials (tyrosyl-arginyl-phenylalanyl-lysinamide) | Recent Studies (post-2010) (tyrosyl-arginyl-phenylalanyl-lysinamide) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 74 | 0 | 17 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | tyrosyl-arginyl-phenylalanyl-lysinamide (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Imam, MZ; Kong, D; Kuo, A; Smith, MT; Williams, CM | 1 |
| Boura, AL; Callaway, JK; King, RG | 1 |
| Boura, AL; King, RG; Olley, JE; Rechtman, MP; Schiller, PW | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Schiller, PW; Shimoyama, M; Shimoyama, N; Szeto, HH; Zhao, GM | 1 |
| Neilan, CL; Nguyen, TM; Pasternak, GW; Schiller, PW | 1 |
| Ben, Y; Furst, S; Lee, NM; Nguyen, TM; Riba, P; Schiller, PW | 1 |
| Berezowska, I; Schiller, PW; Shimoyama, M; Soong, Y; Szeto, HH; Wu, D; Zhao, GM | 1 |
| Schiller, PW; Shimoyama, M; Shimoyama, N; Szeto, HH; Toyama, S | 1 |
| Holloway, AC; Nurse, CA; Salman, S | 1 |
| Eddinger, KA; Huerta-Esquivel, LL; Kokubu, S; Nguyen, TM; Schiller, PW; Yaksh, TL; Yamaguchi, S | 1 |
| Breivik, H; Kontinen, V | 1 |
12 other study(ies) available for tyrosyl-arginyl-phenylalanyl-lysinamide and morphine
| Article | Year |
|---|---|
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
Topics: Analgesics, Opioid; Animals; Biological Products; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Discovery; Humans; Ligands; Pain; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2022 |
Evidence for peripheral mechanisms mediating the antitussive actions of opioids in the guinea pig.
Topics: Administration, Inhalation; Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Dextromethorphan; Female; Guinea Pigs; Injections, Intraperitoneal; Morphine; Naloxone; Narcotics; Oligopeptides; Oxymorphone; Peripheral Nerves | 1991 |
Effects of morphine, H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and B-HT920 on non-cholinergic nerve-mediated bronchoconstriction in pithed guinea-pigs.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Azepines; Bronchoconstriction; Decerebrate State; Electric Stimulation; Guinea Pigs; Male; Molecular Sequence Data; Morphine; Oligopeptides; Peripheral Nerves; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naloxone; Norepinephrine; Oligopeptides; Rats; Rats, Sprague-Dawley; Respiration; Serotonin; Yohimbine | 2001 |
Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Opioid Peptides; Pain Measurement; Receptors, Opioid, mu; Time Factors | 2001 |
[Dmt(1)]DALDA is highly selective and potent at mu opioid receptors, but is not cross-tolerant with systemic morphine.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, mu; Spinal Cord; Time Factors | 2002 |
Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptors.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Injections, Spinal; Injections, Subcutaneous; Kinetics; Male; Mice; Morphine; Oligopeptides; Pain Measurement; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 2002 |
Superior analgesic effect of H-Dmt-D-Arg-Phe-Lys-NH2 ([Dmt1]DALDA), a multifunctional opioid peptide, compared to morphine in a rat model of neuropathic pain.
Topics: Analgesics, Opioid; Animals; Male; Morphine; Neuralgia; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2012 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2014 |
Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Escape Reaction; Fentanyl; Injections, Spinal; Male; Morphine; Oligopeptides; Pain; Pain Measurement; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2019 |
The Yaksh-model of intrathecal opioid-studies: still exciting four decades later.
Topics: Analgesics, Opioid; Morphine; Oligopeptides | 2019 |