tyrosine has been researched along with wortmannin in 134 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 60 (44.78) | 18.2507 |
| 2000's | 73 (54.48) | 29.6817 |
| 2010's | 1 (0.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Blume-Jensen, P; Gout, I; Heldin, CH; Rönnstrand, L; Waterfield, MD | 1 |
| Fukui, Y; Hazeki, K; Hazeki, O; Ninomiya, N; Okada, T; Seya, T; Ui, M | 1 |
| Anderson, NG; Kilgour, E | 1 |
| Parry, R; Sansom, D; Ward, S; Westwick, J; Wilson, A | 1 |
| Corvera, S; Joly, M; Kazlauskas, A | 1 |
| Lu, Y; Phillips, CA; Trevillyan, JM | 1 |
| Bourgoin, S; Caon, AC; Gaudry, M; Gilbert, C; Naccache, PH; Poubelle, PE; Roberge, CJ | 1 |
| Finkelstein, LD; Hunt, SW; Mobley, JL; Shimizu, Y; Zell, T | 1 |
| Claesson-Welsh, L; Hooshmand-Rad, R; Rankin, S; Rozengurt, E | 1 |
| Hazeki, K; Hazeki, O; Katada, T; Sasaki, T; Ui, M | 1 |
| Altman, A; Bonnefoy-Bérard, N; Jascur, T; Matsuda, Y; Mustelin, T; Von Willebrand, M; Yano, H | 1 |
| Goldstein, BJ; Li, PM | 1 |
| Ethier, SP; Ram, TG | 1 |
| Barnard, ML; Bell, JD; Bhakoo, K; Chilvers, EJ; Murray, J; Nunn, AV | 1 |
| Dennis, PB; Kozma, SC; Pullen, N; Thomas, G | 1 |
| Biener, Y; Feinstein, R; Kaburagi, Y; Kadowaki, T; Mayak, M; Zick, Y | 1 |
| Begum, N; Ragolia, L | 1 |
| Enokido, Y; Hatanaka, H; Kubo, T; Nonomura, T; Oka, T; Shimoke, K; Yamada, M | 1 |
| Crespo, P; Gutkind, JS; Lopez-Ilasaca, M; Pellici, PG; Wetzker, R | 1 |
| Furuya, W; Grinstein, S; Krump, E; Pelech, SL; Sanghera, JS | 1 |
| Diegel, ML; Kiener, PA; Ledbetter, JA; Lioubin, MN; Nadler, SG; Rohrschneider, LR | 1 |
| Casamassima, A; Rozengurt, E | 2 |
| Gutkind, JS; Heidaran, MA; Kazlauskas, A; Li, W; Lopez-Ilasaca, M; Uren, A; Yu, JC | 1 |
| Allison, G; Elenius, K; Klagsbrun, M; Paul, S; Sun, J | 1 |
| Kolios, G; Ward, SG; Westwick, J; Wright, K | 1 |
| Anai, M; Asano, T; Fukushima, Y; Funaki, M; Inukai, K; Ishihara, H; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Shin, BC; Takata, K; Yazaki, Y | 1 |
| Mullersman, JE; Murti, A; Pfeffer, LM; Pfeffer, SR; Shi, W; Yang, CH | 1 |
| Homburg, CH; Ibarrola, I; Kessler, J; Koenderman, L; Roos, D; Schweizer, RC; Verhoeven, AJ; Vossebeld, PJ | 1 |
| DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J | 1 |
| Hordijk, PL; Kranenburg, O; Moolenaar, WH; Verlaan, I | 1 |
| Hirai, H; Honda, H; Mitani, K; Miyagawa, K; Nakamoto, T; Sasaki, K; Ueno, H; Yamagata, T; Yazaki, Y | 1 |
| Bloom, ET; Domae, N; Huang, JY; Kono, T; Okazaki, T; Tabassam, FH; Umehara, H | 1 |
| Le Marchand-Brustel, Y; Ricort, JM; Tanti, JF; Van Obberghen, E | 1 |
| Claesson-Welsh, L; Heldin, CH; Hooshmand-Rad, R; Siegbahn, A; Wennström, S; Yokote, K | 1 |
| Minokoshi, Y; Shimazu, T; Shimizu, Y; Tanishita, T | 1 |
| Boothby, M; Keegan, AD; Wang, D; Zamorano, J | 1 |
| Brunton, VG; Cross, MJ; Hill, R; Hodgkin, MN; Kerr, DJ; MacAully, G; Plumb, JA; Stewart, A; Wakelam, MJ; Workman, P | 1 |
| Fisher, SK; Linseman, DA; McEwen, EL; Sorensen, SD | 1 |
| Bos, JL; Burgering, BM; de Rooij, J; Downward, J; Marte, B; van Weering, DH | 1 |
| Anand-Srivastava, MB; Pandey, SK; Srivastava, AK | 1 |
| Katagiri, Y; Nakamura, M; Nakashima, S; Nozawa, Y | 1 |
| Akanuma, Y; Kaburagi, Y; Kadowaki, T; Kerr, IM; Komuro, I; Stark, GR; Tobe, K; Tsuji, Y; Tsushima, T; Ueki, K; Yamauchi, T; Yazaki, Y | 1 |
| Ashford, ML; Harvey, J | 1 |
| Cheng, K; Koland, JG; Vijapurkar, U | 1 |
| Feldman, EL; Kim, B | 1 |
| Czech, MP; Guilherme, A; Torres, K | 1 |
| Druker, BJ; Handa, M; Ikeda, Y; Miyakawa, Y; Ochs, HD; Oda, A; Ozaki, K; Watanabe, C | 1 |
| Cengel, KA; Freund, GG; Kason, RE | 1 |
| Barratt, CL; Brewis, IA; Cooke, ID; Fisher, HM; Moore, HD | 1 |
| Bondada, S; Buhl, AM; Cambier, JC; Chen, CS; Lu, PJ; Venkataraman, C | 1 |
| Barz, C; Imboden, JB; Nagel, T; Truitt, KE | 1 |
| Medalia, O; Sagi-Eisenberg, R; Shefler, I; Taube, Z | 1 |
| Aizu-Yokota, E; Kasahara, T; Matsumoto, Y; Sonoda, Y; Watanabe, S | 1 |
| Ahmad, F; Degerman, E; Gao, G; Landstrom, TR; Manganiello, VC; Pierce, JH; Wang, LM | 1 |
| Fuortes, M; Han, H; Lyon, GJ; Melchior, M; Nathan, C | 1 |
| Clunn, GF; Gallagher, KL; Hughes, AD; Lymn, JS; O'Neil, C; Rao, SJ; Thompson, NT | 1 |
| Peerschke, EI | 1 |
| Finkelstein, LD; Shimizu, Y | 1 |
| Chen, YQ; Wang, MH; Xiao, ZQ | 1 |
| Beguinot, F; Carvalho, E; Formisano, P; Mosialou, E; Rondinone, C; Smith, U | 1 |
| Eckel, J; Kessler, A; Ouwens, DM; Till, M | 1 |
| Rosado, JA; Sage, SO | 1 |
| Fujimoto, J; Furuyama, J; Hashimoto-Tamaoki, T; Itoh, T; Kishimoto, K; Nakanishi, K; Okamoto, E; Sasaki, Y; Ueki, T | 1 |
| Fleck, E; Goetze, S; Hsueh, WA; Kawano, H; Kawano, Y; Kintscher, U; Law, RE; Wakino, S | 1 |
| Klip, A; Ramlal, T; Somwar, R; Tritschler, HJ; Yaworsky, K | 1 |
| Araki, Y; Sendo, F; Yu, Y | 1 |
| Decker, SJ; Prasad, N; Topping, RS; Zhou, D | 1 |
| Imamura, T; Janez, A; Olefsky, JM; Sharma, PM; Worrall, DS | 1 |
| Birnbaum, MJ; Gaslightwala, I; Nakagawa, H; Okano, J; Rustgi, AK | 1 |
| Jenner, S; Sage, SO | 1 |
| Fukami, MH; Holmsen, H; Selheim, F; Vassbotn, FS | 1 |
| Frank, SJ; Jiang, J; Liang, L | 1 |
| Lidder, S; Riordan, SM; Skouteris, GG; Williams, R | 1 |
| Dietz, R; Dumler, I; Gulba, DC; Haller, H; Kusch, A; Lipp, M; Tkachuk, S | 1 |
| Funahashi, H; Hayashi, H; Ichihara, M; Imai, T; Iwashita, T; Kawai, K; Kurokawa, K; Murakami, H; Murakumo, Y; Nakao, A; Shimono, Y; Takahashi, M | 1 |
| Avvedimento, E; Costanzo, V; Gautier, J; Gottesman, M; Grieco, D; Kim, E; Robertson, K; Ying, CY | 1 |
| Holbrook, NJ; Klotz, LO; Schieke, SM; Sies, H | 1 |
| Baba, A; Hashimoto, H; Koyama, Y; Matsuda, T; Yoshioka, Y | 1 |
| Cardin, V; Crevenna, A; Morales-Mulia, S; Pasantes-Morales, H; Torres-Márquez, ME | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Biden, TJ; Blewitt, M; Kelly, MM; Mitchell, CJ; Wilson, JR | 1 |
| Alt, A; Herschkovitz, A; Kuroki, T; LeRoith, D; Liu, YF; Ohba, M; Paz, K; Sampson, SR; Tennenbaum, T; Zick, Y | 1 |
| Chen, EY; Cooper, JA; Giaccia, AJ; Mazure, NM | 1 |
| Fish, EN; Fujita, S; Grumbach, IM; Lekmine, F; Majchrzak, B; Mayer, IA; Platanias, LC; Ravandi, F; Uddin, S; Verma, A | 1 |
| Barrett, KE; Calandrella, S; Chang, N; Keely, SJ; Uribe, JM | 1 |
| Adachi, H; Fujioka, T; Kim, JH; Saito, K; Tsujimoto, M; Ui, M; Yokoyama, S | 1 |
| Guillemot, L; Levy, A; Raymondjean, M; Rothhut, B | 1 |
| Bisotto, S; Fixman, ED | 1 |
| Bachurski, CJ; Bruno, T; Degen, SJ; Kaestner, KH; Leikauf, GD; Mallakin, A; McDowell, SA; Melin-Aldana, H; Prows, DR; Toney-Earley, K; Waltz, SE; Witte, DP | 1 |
| Aschenbach, WG; Goodyear, LJ; Hirshman, MF; Sakamoto, K | 1 |
| Clarkson, B; Liang, X; Resh, MD; Strife, A; Wisniewski, D | 1 |
| Cartel, NJ; Post, M; Wang, J | 1 |
| Schwarzbauer, JE; Wierzbicka-Patynowski, I | 1 |
| Gonzalez, G; Mora, N; Reyes-Reyes, M; Rosales, C | 1 |
| Lachance, G; Levasseur, S; Naccache, PH | 1 |
| Anderson, N; Clayton, PE; Freeth, JS; Huynh, T; Kloth, MT; Laughlin, KK; Silva, CM; Whatmore, AJ; Woodall, AJ | 1 |
| Chock, PB; Qin, S | 1 |
| Bell, CJ; Denton, RM; Hers, I; Jiang, D; Poole, AW; Schaefer, E; Tavaré, JM | 1 |
| Chap, H; Iberg, N; Morand, O; Paulhe, F; Perret, B; Racaud-Sultan, C | 1 |
| Blommaart, EF; Burger, HJ; Dubbelhuis, PF; Gustafson, LA; Herling, AW; Meijer, AJ; Van Sluijters, DA; Van Woerkom, GM | 1 |
| Bertics, PJ; Dam, P; Kim, YN | 1 |
| Chiasson, JL; Coderre, L; Julien, N; Tardif, A | 1 |
| Oehrl, W; Rubio, I; Wetzker, R | 1 |
| Hashimoto, N; Kawanabe, Y; Masaki, T | 1 |
| Owen, JS; Sacre, SM; Stannard, AK | 1 |
| Bai, RY; Bassermann, F; Duyster, J; Klumpen, S; Miething, C; Morris, SW; Ouyang, T; Peschel, C; von Klitzing, C | 1 |
| Druet, V; Klein, JP; Neff, L; Sibilia, J; Takeda, K; Wachsmann, D; Zeisel, M | 1 |
| Adam, F; Guillin, MC; Jandrot-Perrus, M | 1 |
| Castranova, V; Hur, KC; Kang, JL; Lee, HS; Pack, IS | 1 |
| Han, DH; Hansen, PA; Holloszy, JO; Hucker, KA; Nolte, LA | 1 |
| Barrett, KE; Bertelsen, LS; Keely, SJ | 1 |
| Clunn, GF; Fexby, SE; Gallagher, KL; Hughes, AD; Lymn, JS; Patel, MK | 1 |
| Inanami, O; Kuwabara, M; Nagahata, H; Yamamori, T | 1 |
| Ishida, T; Kamano, H; Kitanaka, A; Kubota, Y; Ohnishi, H; Okutani, Y; Taminato, T; Tanaka, T | 1 |
| Fan, RS; Hunger-Glaser, I; Perez-Salazar, E; Rozengurt, E | 1 |
| Cheng, CY; Lee, WM; Siu, MK; Wong, CH | 1 |
| Wang, MH; Xu, XM; Zhou, YQ | 1 |
| Panetti, TS; Teckchandani, AM; Tsygankov, AY | 1 |
| Endo, Y; Fujita, T; Horita, S; Kadowaki, T; Kunimi, M; Li, Y; Sakamoto, K; Seki, G; Terauchi, Y; Tobe, K; Yamada, H; Zheng, Y | 1 |
| Bragado, MJ; Cerezo-Guisado, MI; Garcia-Marin, LJ; Lorenzo, MJ | 1 |
| Chang, LC; Chen, BH; Chen, HC; Cheng, CH; Huang, CH | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Fukuyama, T; Inagaki, M; Kawakatsu, T; Ogita, H; Takai, Y | 1 |
| Kucerová, D; Sloncová, E; Tuhácková, Z; Turecková, J; Vojtechová, M | 1 |
| Handa, M; Jung, SM; Moroi, M; Ohnuma, M; Sonoda, M; Watanabe, N | 1 |
| Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y | 1 |
| de Lamirande, E; Gagnon, C; O'Flaherty, C | 1 |
| Colonna, M; Fuchs, A; Fung-Leung, WP; Gu, Y; Karlsson, L; Lai, KT; Rao, N; Sanjuan, MA; Sun, S | 1 |
| daSilva, LL; Denecke, J; Foresti, O | 1 |
| Alvarez, SE; Ayub, MJ; Ciuffo, GM; Villarreal, RS | 1 |
| Cid, LP; Cornejo, I; Niemeyer, MI; Sepúlveda, FV; Yusef, YR; Zúñiga, L | 1 |
| Chen, NN; Liu, B; Liu, D; Liu, GP; Luo, DJ; Ni, ZF; Wang, JZ; Wang, Q; Wang, X; Yao, XQ; Yin, YY; Zhang, XX | 1 |
134 other study(ies) available for tyrosine and wortmannin
| Article | Year |
|---|---|
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Aorta; Endothelium, Vascular; GRB2 Adaptor Protein; Hematopoietic Cell Growth Factors; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-raf; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Stem Cell Factor; Swine; Transfection; Type C Phospholipases; Tyrosine; Wortmannin | 1994 |
Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.
Topics: Androstadienes; Animals; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Macromolecular Substances; Neutrophils; Phagocytosis; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphopeptides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1994 |
Differential effects of wortmannin on growth hormone dependent signalling pathways in 3T3-F442A cells.
Topics: 3T3 Cells; Androstadienes; Animals; Culture Media, Serum-Free; Growth Hormone; Insulin Antagonists; Kinetics; Mice; Molecular Weight; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tyrosine; Wortmannin | 1995 |
The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.
Topics: Androstadienes; Animals; CD28 Antigens; Cell Line; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Lymphocyte Activation; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1995 |
Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking.
Topics: Androstadienes; Binding Sites; Biological Transport; Cell Line; Down-Regulation; Endocytosis; Humans; Hydrolysis; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptors, Platelet-Derived Growth Factor; Tyrosine; Wortmannin | 1995 |
Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin.
Topics: Androstadienes; CD28 Antigens; Humans; Interleukin-2; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1995 |
Inhibition of tyrosine phosphorylation by wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D.
Topics: Androstadienes; Biological Transport; Calcium; Enzyme Activation; Estrenes; Humans; Neutrophils; Phospholipase D; Phosphorylation; Pyrrolidinones; Type C Phospholipases; Tyrosine; Wortmannin | 1993 |
CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase.
Topics: Amino Acid Sequence; Androstadienes; Base Sequence; CD2 Antigens; CD28 Antigens; Cell Line; Fibronectins; Genetic Vectors; Humans; Integrin beta1; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Recombinant Proteins; Tyrosine; Up-Regulation; Wortmannin | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Androstadienes; Animals; Cell Adhesion Molecules; Ceramides; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Signal Transduction; Sphingomyelin Phosphodiesterase; Substrate Specificity; Tyrosine; Wortmannin | 1996 |
Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2.
Topics: Amino Acid Sequence; Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; DNA Replication; Enzyme Activation; Humans; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells.
Topics: Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Liver Neoplasms, Experimental; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Receptor, Insulin; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplifi
Topics: Androstadienes; Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Blotting, Western; Breast Neoplasms; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Glycoproteins; Humans; Insulin-Like Growth Factor I; Mitogens; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Characterisation of secondary metabolites associated with neutrophil apoptosis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Androstadienes; Apoptosis; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Neutrophils; Phosphorylcholine; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 1996 |
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.
Topics: Amino Acid Sequence; Androstadienes; Cell Line; Humans; Immunosuppressive Agents; Kidney; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotinic Acids; Peptide Mapping; Phosphates; Phosphodiesterase Inhibitors; Phosphopeptides; Phosphorylation; Polyenes; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sequence Deletion; Sirolimus; Transfection; Tyrosine; Wortmannin | 1996 |
Annexin II is a novel player in insulin signal transduction. Possible association between annexin II phosphorylation and insulin receptor internalization.
Topics: Androstadienes; Animals; Annexin A2; Catechols; CHO Cells; Cricetinae; Endocytosis; Enzyme Inhibitors; Insulin; Kinetics; Mutation; Nitriles; Phosphorylation; Potassium; Protein-Tyrosine Kinases; Receptor, Insulin; Signal Transduction; Tyrosine; Tyrphostins; Wortmannin | 1996 |
cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells.
Topics: Androstadienes; Animals; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Immunosuppressive Agents; Insulin; Kinetics; Muscle, Skeletal; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Rats; Sirolimus; Tyrosine; Vanadates; Wortmannin | 1996 |
Signaling pathways and survival effects of BDNF and NT-3 on cultured cerebellar granule cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Animals; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Isoenzymes; Nerve Growth Factors; Neurotrophin 3; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proteins; Proto-Oncogene Proteins c-fos; Rats; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases; Tyrosine; Wortmannin | 1996 |
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Membrane; COS Cells; Enzyme Activation; GRB2 Adaptor Protein; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Mitogen-Activated Protein Kinase 1; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proteins; ras Guanine Nucleotide Exchange Factors; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Muscarinic M2; Receptors, Muscarinic; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine; Wortmannin | 1997 |
Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Humans; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tyrosine; Wortmannin | 1997 |
Co-ligation of the antigen and Fc receptors gives rise to the selective modulation of intracellular signaling in B cells. Regulation of the association of phosphatidylinositol 3-kinase and inositol 5'-phosphatase with the antigen receptor complex.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; B-Lymphocytes; GRB2 Adaptor Protein; Intracellular Signaling Peptides and Proteins; Kinetics; Mice; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Receptors, Fc; Signal Transduction; Tyrosine; Wortmannin | 1997 |
Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Bradykinin; Calcium; Chromones; Crk-Associated Substrate Protein; Endothelins; Enzyme Inhibitors; Lysophospholipids; Mice; Morpholines; Phorbol Esters; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Tyrosine; Ubiquitin-Protein Ligases; Vasopressins; Wortmannin | 1997 |
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Enzyme Activation; GTP-Binding Proteins; JNK Mitogen-Activated Protein Kinases; Ligands; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Proto-Oncogene Proteins p21(ras); Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; rho GTP-Binding Proteins; Tyrosine; Wortmannin | 1997 |
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.
Topics: 3T3 Cells; Androstadienes; Animals; Cell Division; Chemotaxis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Ligands; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, ErbB-4; Transfection; Tyrosine; Wortmannin | 1997 |
Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29.
Topics: Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Epithelium; Gene Expression Regulation, Enzymologic; Humans; Insulin Receptor Substrate Proteins; Interleukin-13; Morpholines; Nitric Oxide Synthase; Nitrites; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Tyrosine; Wortmannin | 1997 |
Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells.
Topics: Androstadienes; Animals; Cells, Cultured; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Rats; Tyrosine; Wortmannin | 1997 |
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor.
Topics: Acute-Phase Proteins; Amino Acid Sequence; Androstadienes; Animals; Binding Sites; Cell Line; Cloning, Molecular; Conserved Sequence; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Membrane Proteins; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Protein Binding; Receptor, Interferon alpha-beta; Receptors, Interferon; Recombinant Fusion Proteins; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine; Wortmannin | 1997 |
Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcgamma receptor cross-linking in human neutrophils.
Topics: Androstadienes; Calcium; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Receptors, IgG; Signal Transduction; Tyrosine; Wortmannin | 1997 |
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1997 |
Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; COS Cells; Enzyme Activation; GRB2 Adaptor Protein; GTP-Binding Protein alpha Subunits, Gi-Go; Models, Biological; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins pp60(c-src); ras Proteins; Rats; Signal Transduction; src Homology Domains; Tyrosine; Wortmannin | 1997 |
The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Topics: Androstadienes; Animals; Apoptosis; Binding Sites; Cell Line; Cell Survival; Enzyme Inhibitors; Humans; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Ubiquitin-Protein Ligases; Wortmannin | 1997 |
Involvement of protein tyrosine kinase p72syk and phosphatidylinositol 3-kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3.3.
Topics: Androstadienes; Benzoquinones; Carrier Proteins; CD2 Antigens; Cell Line; Cytoplasmic Granules; Enzyme Precursors; Exocytosis; Granzymes; Humans; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lactams, Macrocyclic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Proteins; Quinones; Rifabutin; Serine Endopeptidases; src Homology Domains; Syk Kinase; Tyrosine; Wortmannin | 1997 |
Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Chromones; Enzyme Inhibitors; Insulin; Insulin Antagonists; Insulin Receptor Substrate Proteins; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Signal Transduction; Tyrosine; Wortmannin | 1997 |
Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis.
Topics: Actins; Androstadienes; Animals; Becaplermin; Cell Membrane; Cell Movement; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Enzyme Inhibitors; GTP-Binding Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Polymers; Proto-Oncogene Proteins c-sis; rac GTP-Binding Proteins; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Swine; Tyrosine; Wortmannin | 1997 |
The beta3-adrenergic agonist BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin.
Topics: Adrenergic beta-Agonists; Androstadienes; Animals; Biological Transport; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Ethanolamines; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Kinetics; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Proteins; Rats; Subcellular Fractions; Tyrosine; Wortmannin | 1997 |
HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor.
Topics: Androstadienes; Animals; Antigens, CD; Cell Nucleus; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Hematopoietic Stem Cells; High Mobility Group Proteins; HMGA1a Protein; Humans; Insulin Receptor Substrate Proteins; Macromolecular Substances; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Point Mutation; Rats; Receptors, Interleukin; Receptors, Interleukin-4; Recombinant Proteins; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Transfection; Tyrosine; Wortmannin | 1997 |
Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin.
Topics: 3T3 Cells; Androstadienes; Androstenes; Animals; Bombesin; Cell Division; Enzyme Inhibitors; Insulin; Mice; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phospholipases; Phospholipids; Phosphorylation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Wortmannin | 1997 |
Cytoskeletal and phosphoinositide requirements for muscarinic receptor signaling to focal adhesion kinase and paxillin.
Topics: Actins; Androstadienes; Cell Adhesion; Cell Adhesion Molecules; Chromones; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Humans; Lovastatin; Morpholines; Muscarinic Agonists; Neuroblastoma; Nucleic Acid Synthesis Inhibitors; Paxillin; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Muscarinic; Second Messenger Systems; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Topics: Androstadienes; Cell Movement; Chromones; Cytoplasm; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; ras Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Enzyme Activation; Flavonoids; Glycogen; Humans; Insulin Receptor Substrate Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Receptor, Insulin; Ribosomal Protein S6 Kinases; Sirolimus; Tyrosine; Vanadium Compounds; Wortmannin | 1998 |
Involvement of tyrosine phosphorylation in inhibition of fMLP-induced PLD activation by N-acetyl-L-cysteine in differentiated HL60 cells.
Topics: Acetylcysteine; Androstadienes; Cell Differentiation; Chelating Agents; Cysteine; Dithiothreitol; Enzyme Activation; Free Radical Scavengers; HL-60 Cells; Humans; Inositol Phosphates; N-Formylmethionine Leucyl-Phenylalanine; Oxidants; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorylation; Sulfhydryl Reagents; Tyrosine; Unithiol; Wortmannin | 1998 |
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
Topics: Androstadienes; Animals; Enzyme Activation; Growth Hormone; Insulin Antagonists; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Liver; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, Insulin; Tyrosine; Wortmannin | 1998 |
Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line CRI-G1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Androstadienes; Animals; Enzyme Inhibitors; Insulinoma; Leptin; Nitriles; Pancreatic Neoplasms; Phosphoric Monoester Hydrolases; Phosphorylation; Potassium Channels; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Rats; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 1998 |
Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase.
Topics: 3T3 Cells; Androstadienes; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; DNA Primers; DNA Replication; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Mice; Mutagenesis, Site-Directed; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins; Rats; Receptor, ErbB-3; Signal Transduction; Thymidine; Transfection; Tritium; Tyrosine; Wortmannin | 1998 |
Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Chromones; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways.
Topics: Androstadienes; Animals; Cell Adhesion; CHO Cells; Cricetinae; Fibronectins; Insulin; Insulin Receptor Substrate Proteins; Integrins; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptor, Insulin; Receptors, Fibronectin; Signal Transduction; Tyrosine; Wortmannin | 1998 |
Collagen induces tyrosine phosphorylation of Wiskott-Aldrich syndrome protein in human platelets.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Blood Platelets; Collagen; Cytoskeleton; Glutathione Transferase; GRB2 Adaptor Protein; Humans; Phosphorylation; Platelet Aggregation; Protein Binding; Proteins; Tyrosine; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein; Wortmannin | 1998 |
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Cell Adhesion Molecules; Chromones; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Wortmannin | 1998 |
Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase.
Topics: Androstadienes; Humans; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptor, Insulin; Recombinant Fusion Proteins; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine; Wortmannin | 1998 |
Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation.
Topics: Acrosome Reaction; Androstadienes; Blotting, Western; Calcimycin; Enzyme Inhibitors; Humans; In Vitro Techniques; Ionophores; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Progesterone; Signal Transduction; Spermatozoa; Tyrosine; Wortmannin | 1998 |
CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cell Division; Chromones; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Female; Immunoglobulin alpha-Chains; Intracellular Signaling Peptides and Proteins; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Complement 3b; Receptors, Complement 3d; Receptors, IgG; Syk Kinase; Tyrosine; Wortmannin | 1998 |
Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production.
Topics: Amino Acid Sequence; Amino Acid Substitution; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CD28 Antigens; CD3 Complex; Cytoplasm; DNA Mutational Analysis; Enzyme Activation; Humans; Interleukin-2; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Peptide Fragments; Transfection; Tyrosine; Wortmannin | 1998 |
Basic secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and phosphatidylinositol 3-kinase-dependent mechanism.
Topics: Androstadienes; Animals; Arachidonic Acid; Mast Cells; p-Methoxy-N-methylphenethylamine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Rats; Tyrosine; Wortmannin | 1998 |
FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Adhesion Molecules; DNA Fragmentation; Down-Regulation; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Hydrogen Peroxide; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Serine; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1999 |
IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Insulin Receptor Substrate Proteins; Interleukin-3; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction; STAT6 Transcription Factor; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.
Topics: Androstadienes; Cell Adhesion; Cell Size; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 2; Humans; Integrins; Neutrophil Activation; Neutrophils; Nitriles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
Phosphatidylinositol 3-kinase and focal adhesion kinase are early signals in the growth factor-like responses to thrombospondin-1 seen in human vascular smooth muscle.
Topics: Androstadienes; Cell Adhesion Molecules; Cells, Cultured; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Humans; Isoenzymes; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Thrombospondin 1; Tyrosine; Wortmannin | 1999 |
Maintenance of GPIIb-IIIa avidity supporting "irreversible" fibrinogen binding is energy-dependent.
Topics: Adenosine Diphosphate; Androstadienes; Anti-Bacterial Agents; Antibodies, Monoclonal; Antimetabolites; Antimycin A; Benzoquinones; Blood Platelets; Deoxyglucose; Dimethyl Sulfoxide; Energy Metabolism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excipients; Fibrinogen; Humans; Lactams, Macrocyclic; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Polylysine; Protein Binding; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Tyrosine; Wortmannin | 1999 |
Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Adhesion; Chromones; HL-60 Cells; Humans; Integrin alpha4beta1; Integrins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-cbl; Receptors, Lymphocyte Homing; Recombinant Fusion Proteins; Tyrosine; Ubiquitin-Protein Ligases; Wortmannin | 2000 |
Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration.
Topics: Amino Acid Substitution; Androstadienes; Animals; Binding Sites; Cell Line; Cell Movement; Dogs; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; Mice; Mutagenesis, Site-Directed; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rabbits; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Signal Transduction; Tyrosine; Wortmannin | 2000 |
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Androstadienes; Animals; Azepines; Biological Transport; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Insulin-Like Growth Factor II; Lipolysis; Male; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Tyrosine; Wortmannin | 2000 |
Molecular mechanisms of contraction-regulated cardiac glucose transport.
Topics: Androstadienes; Animals; Biological Transport; Calcium; Chromones; Glucose; Glucose Transporter Type 4; Heart; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Monosaccharide Transport Proteins; Morpholines; Muscle Proteins; Myocardial Contraction; Myocardium; Phosphoproteins; Phosphorylation; Precipitin Tests; Rats; Rats, Wistar; Signal Transduction; Tyrosine; Wortmannin | 2000 |
Phosphoinositides are required for store-mediated calcium entry in human platelets.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Blood Platelets; Calcium; Chromones; Enzyme Inhibitors; Humans; In Vitro Techniques; Ion Transport; Morpholines; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Thrombin; Tyrosine; Wortmannin | 2000 |
Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase.
Topics: Androstadienes; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Hepatocyte Growth Factor; Humans; Isoenzymes; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1999 |
Tumor necrosis factor alpha inhibits insulin-induced mitogenic signaling in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2000 |
Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Biological Transport; Enzyme Activation; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Osmolar Concentration; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Thioctic Acid; Tyrosine; Wortmannin | 2000 |
Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration.
Topics: Amidohydrolases; Androstadienes; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Chelating Agents; Cross-Linking Reagents; Cytochalasin B; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Indoles; Mice; Mice, Inbred BALB C; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Signal Transduction; Time Factors; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Cell Line; Humans; Hydrogen Peroxide; Immediate-Early Proteins; Nerve Growth Factor; Nuclear Proteins; Oxidative Stress; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tyrosine; Vanadates; Wortmannin | 2000 |
The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Androstadienes; Animals; Biological Transport; Enzyme Inhibitors; Glucose; Mice; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Sorbitol; Tyrosine; Wortmannin | 2000 |
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.
Topics: Androstadienes; Blotting, Southern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dimerization; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Esophageal Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Ligands; Morpholines; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
Two pathways for store-mediated calcium entry in human platelets.
Topics: Androstadienes; Biological Transport; Blood Platelets; Calcium; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Econazole; Egtazic Acid; Enzyme Inhibitors; Humans; Imidazoles; Ionomycin; Ionophores; Lanthanum; Manganese; Phosphorylation; Protein-Tyrosine Kinases; Thapsigargin; Tyrosine; Wortmannin | 2000 |
Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation.
Topics: Androstadienes; Blood Platelets; Chromatography, High Pressure Liquid; Chromones; Collagen; Enzyme Inhibitors; Flow Cytometry; Humans; Immunoblotting; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Platelet Activation; Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 2000 |
Insulin receptor substrate-1-mediated enhancement of growth hormone-induced mitogen-activated protein kinase activation.
Topics: Androstadienes; Animals; Blotting, Western; Cells, Cultured; Densitometry; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Genes, ras; Growth Hormone; Humans; Insulin Receptor Substrate Proteins; Milk Proteins; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Transfection; Tyrosine; Wortmannin | 2000 |
The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Cytochalasin D; GRB2 Adaptor Protein; Hepatocyte Growth Factor; Humans; Mitosis; Phosphorylation; Protein Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction.
Topics: Androstadienes; Blotting, Northern; Cell Movement; Cells, Cultured; Chemotaxis; Chromones; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Glutathione Transferase; Humans; Microscopy, Fluorescence; Microscopy, Video; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; RNA; Signal Transduction; src Homology Domains; Time Factors; Transcription, Genetic; TYK2 Kinase; Tyrosine; Urokinase-Type Plasminogen Activator; Wortmannin | 2000 |
Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Cyclic AMP Response Element-Binding Protein; Drosophila Proteins; Enzyme Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; GRB2 Adaptor Protein; Humans; Mitogen-Activated Protein Kinase 1; Nerve Growth Factors; Nerve Tissue Proteins; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; ras Proteins; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Caffeine; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell-Free System; Chromosomes; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Damage; DNA Replication; DNA-Binding Proteins; Enzyme Inhibitors; Male; Mutagenesis; Nuclear Proteins; Oocytes; Phosphodiesterase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Replication Origin; S Phase; Saccharomyces cerevisiae Proteins; Signal Transduction; Spermatozoa; Transcription, Genetic; Tumor Suppressor Proteins; Tyrosine; Wortmannin; Xenopus; Xenopus Proteins | 2000 |
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Molsidomine; Morpholines; Nitrates; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Skin; Time Factors; Tyrosine; Tyrphostins; Wortmannin | 2000 |
Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.
Topics: Androstadienes; Angiotensin II; Animals; Animals, Newborn; Astrocytes; Bradykinin; Bucladesine; Cerebral Cortex; Chelating Agents; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Pertussis Toxin; Phosphoproteins; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Influence of protein kinases on the osmosensitive release of taurine from cerebellar granule neurons.
Topics: Androstadienes; Animals; Calcium; Cerebellum; Enzyme Activation; Enzyme Inhibitors; Intracellular Membranes; Mitogen-Activated Protein Kinases; Neurons; Osmolar Concentration; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Rats; Taurine; Tyrosine; Water-Electrolyte Balance; Wortmannin | 2001 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Phospholipase C-gamma mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans.
Topics: Adenoviridae; Androstadienes; Animals; Carbachol; Cholinergic Agonists; Chromatography, High Pressure Liquid; Chromones; Enzyme Inhibitors; Genistein; Hydrolysis; Inositol Phosphates; Islets of Langerhans; Isoenzymes; Membrane Potentials; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Rats; Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine; Vanadates; Wortmannin | 2001 |
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
Topics: Adenoviridae; Androstadienes; Animals; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Threonine; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2001 |
Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Hypoxia; Cell Line; Dogs; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Fibrosarcoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Kidney; Oxygen; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2001 |
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
Topics: Androstadienes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genistein; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Intracellular Signaling Peptides and Proteins; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tyrosine; Wortmannin | 2001 |
Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells.
Topics: Androstadienes; Carbachol; Cells, Cultured; Chlorides; Cholinergic Agonists; Chromones; Colon; Diabetes Mellitus; Diarrhea; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Intestinal Mucosa; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Thapsigargin; Tyrosine; Wortmannin | 2001 |
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 2001 |
Angiotensin II-induced transcriptional activation of the cyclin D1 gene is mediated by Egr-1 in CHO-AT(1A) cells.
Topics: Androstadienes; Angiotensin II; Animals; Binding Sites; Butadienes; Cell Line; Cell Nucleus; CHO Cells; Cricetinae; Cyclin D1; DNA Mutational Analysis; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Genes, Dominant; Humans; Immediate-Early Proteins; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mutagenesis, Site-Directed; Nitriles; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Transcription Factors; Transcriptional Activation; Transfection; Tyrosine; Up-Regulation; Wortmannin | 2001 |
Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Receptor, Endothelin A; Receptors, Endothelin; src Homology Domains; src-Family Kinases; Time Factors; Tyrosine; Wortmannin | 2001 |
The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury.
Topics: Androstadienes; Animals; Cell Survival; Chemokine CCL2; Chemokine CCL8; Cytokines; Cytoplasm; DNA, Complementary; Female; Gene Deletion; Genotype; Humans; Interleukin-6; Lung Injury; Macrophages, Alveolar; Male; Mice; Monocyte Chemoattractant Proteins; Nickel; Nitrites; Oligonucleotide Array Sequence Analysis; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Respiratory Distress Syndrome; Signal Transduction; Time Factors; Tyrosine; Wortmannin | 2002 |
Contraction regulation of Akt in rat skeletal muscle.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Morpholines; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Serine; Signal Transduction; Threonine; Time Factors; Tyrosine; Wortmannin | 2002 |
Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.
Topics: Androstadienes; Animals; Cell Division; Cell Line; Cell Membrane; COS Cells; DNA-Binding Proteins; DNA, Complementary; Enzyme Inhibitors; Glutathione Transferase; Humans; Lipid Metabolism; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; RNA-Binding Proteins; Signal Transduction; src-Family Kinases; Subcellular Fractions; Transfection; Tyrosine; Wortmannin | 2002 |
Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.
Topics: Androstadienes; Animals; Becaplermin; Enzyme Inhibitors; Female; Fibroblasts; Genes, Dominant; Glycosaminoglycans; Immunoblotting; Lung; Male; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; rab3 GTP-Binding Proteins; Rats; Rats, Wistar; Signal Transduction; Transfection; Tyrosine; Wortmannin | 2002 |
Regulatory role for SRC and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assembly.
Topics: Androstadienes; Animals; Binding Sites; Chickens; CHO Cells; Cricetinae; Deoxycholic Acid; Detergents; Enzyme Inhibitors; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Time Factors; Tyrosine; Wortmannin | 2002 |
beta1 and beta2 integrins activate different signalling pathways in monocytes.
Topics: Androstadienes; Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion; Cell Line; Chromones; Cross-Linking Reagents; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Humans; Integrin beta1; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Signal Transduction; Syk Kinase; Tyrosine; Wortmannin | 2002 |
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.
Topics: Adenosine Triphosphate; Androstadienes; Cell Membrane; Chemotaxis; Enzyme Inhibitors; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Transport; Protein-Tyrosine Kinases; Signal Transduction; Time Factors; Tyrosine; Virulence Factors, Bordetella; Wortmannin | 2002 |
GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts.
Topics: Abnormalities, Multiple; Androstadienes; Blotting, Western; Child; Epidermal Growth Factor; Female; Fibroblasts; Growth Hormone; Humans; Indicators and Reagents; Janus Kinase 2; Luciferases; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Signal Transduction; Syndrome; Transfection; Tyrosine; Wortmannin | 2002 |
Tyrosine phosphatase CD45 regulates hydrogen peroxide-induced calcium mobilization in B cells.
Topics: Agammaglobulinaemia Tyrosine Kinase; Androstadienes; Animals; B-Lymphocytes; Calcium; Calcium Signaling; Cell Line; Chickens; Enzyme Activation; Hydrogen Peroxide; Inositol 1,4,5-Trisphosphate; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Leukocyte Common Antigens; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Type C Phospholipases; Tyrosine; Wortmannin | 2002 |
Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Binding Sites; Chromones; Enzyme Inhibitors; Epididymis; Gene Expression Regulation; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; Receptor, Insulin; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Tyrosine; Wortmannin | 2002 |
Phosphoinositide 3-kinase C2alpha is activated upon smooth muscle cell migration and regulated by alpha(v)beta(3) integrin engagement.
Topics: Androstadienes; Animals; Aorta; Cell Movement; Cells, Cultured; Chromones; Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Integrin alphaVbeta3; Integrins; Isoenzymes; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptors, Vitronectin; Signal Transduction; Swine; Tyrosine; Wortmannin | 2002 |
Inhibition of autophagic proteolysis by inhibitors of phosphoinositide 3-kinase can interfere with the regulation of glycogen synthesis in isolated hepatocytes.
Topics: Adenosine Triphosphate; Amides; Androstadienes; Animals; Autophagy; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glycogen; Hepatocytes; Imidazoles; Indoles; Insulin; Lactic Acid; Leucine; Male; Morpholines; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Wistar; Tyrosine; Wortmannin | 2002 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Colchicine; Cyclodextrins; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Kinetics; Morpholines; Nucleic Acid Synthesis Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; src-Family Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2002 |
Stimulation of glucose uptake by chronic vanadate pretreatment in cardiomyocytes requires PI 3-kinase and p38 MAPK activation.
Topics: Androstadienes; Animals; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Glucose; Heart; Imidazoles; Immunoblotting; Male; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Stimulation, Chemical; Transcription, Genetic; Tyrosine; Vanadates; Wortmannin | 2003 |
Serine 338 phosphorylation is dispensable for activation of c-Raf1.
Topics: Androstadienes; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Glutathione Transferase; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; Signal Transduction; Time Factors; Tyrosine; U937 Cells; Wortmannin | 2003 |
Involvements of voltage-independent Ca2+ channels and phosphoinositide 3-kinase in endothelin-1-induced PYK2 tyrosine phosphorylation.
Topics: Acetamides; Androstadienes; Animals; Calcium; Calcium Channels; Cells, Cultured; Chromones; Drug Interactions; Endothelin-1; Enzyme Inhibitors; Focal Adhesion Kinase 2; Imidazoles; Isoquinolines; Morpholines; Muscle, Smooth, Vascular; Nifedipine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Wortmannin | 2003 |
Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells.
Topics: Androstadienes; Animals; Apolipoproteins E; Cells, Cultured; CHO Cells; Cricetinae; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Nitric Oxide; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Tyrosine; Wortmannin | 2003 |
Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Androstadienes; Animals; Apoptosis; Blotting, Northern; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cloning, Molecular; COS Cells; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Glutathione Transferase; Humans; Immunoblotting; In Situ Nick-End Labeling; Ki-1 Antigen; Lymphoma, Large B-Cell, Diffuse; Mice; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoamino Acids; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Tissue Distribution; Transfection; Two-Hybrid System Techniques; Type C Phospholipases; Tyrosine; Wortmannin | 2003 |
ERK 1/2- and JNKs-dependent synthesis of interleukins 6 and 8 by fibroblast-like synoviocytes stimulated with protein I/II, a modulin from oral streptococci, requires focal adhesion kinase.
Topics: Active Transport, Cell Nucleus; Androstadienes; Antibodies, Monoclonal; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genes, Dominant; Humans; Inflammation; Integrin alpha5beta1; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Synovial Membrane; Time Factors; Tyrosine; Wortmannin | 2003 |
Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin.
Topics: Adenosine Diphosphate; Androstadienes; Antibodies, Monoclonal; Bernard-Soulier Syndrome; Blood Platelets; Cyclic AMP; Enzyme Inhibitors; Humans; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Receptors, Thrombin; Signal Transduction; Thrombin; Tyrosine; Wortmannin | 2003 |
Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.
Topics: Acetylcysteine; Androstadienes; Animals; Antioxidants; Blotting, Western; Cell Line; Cell Nucleus; eIF-2 Kinase; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Lipopolysaccharides; Mice; Models, Biological; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Pyrrolidines; Reactive Oxygen Species; Silicon Dioxide; Superoxide Dismutase; Thiocarbamates; Time Factors; Tyrosine; Wortmannin | 2003 |
A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Glucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Male; Morpholines; Muscle Contraction; Muscle, Skeletal; Organometallic Compounds; Phenanthrolines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Physical Exertion; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Tyrosine; Vanadates; Wortmannin | 2003 |
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Cattle; DNA; Enzyme Inhibitors; Humans; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serum; Thymidine; Tritium; Tyrosine; Wortmannin | 2003 |
Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.
Topics: Androstadienes; Animals; Blotting, Western; Cell Differentiation; Cell Membrane; Chromones; Cytosol; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Glutathione Transferase; HL-60 Cells; Humans; Immunoblotting; Macrophages; Mice; Models, Biological; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phenotype; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Subcellular Fractions; Superoxides; Time Factors; Type C Phospholipases; Tyrosine; Wortmannin | 2004 |
Constitutively activated phosphatidylinositol 3-kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation.
Topics: Androstadienes; Blood Platelets; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Aggregation; Thrombopoietin; Tyrosine; Wortmannin | 2004 |
PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Serine; Swiss 3T3 Cells; Tyrosine; Wortmannin | 2004 |
Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases.
Topics: Androstadienes; Animals; Cell Communication; Cell Culture Techniques; Chelating Agents; Coculture Techniques; Culture Media; Culture Media, Serum-Free; Cytoskeleton; Edetic Acid; Egtazic Acid; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Germ Cells; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Integrin beta1; Lipid Metabolism; Lipids; Male; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Spermatogenesis; Testis; Time Factors; Tyrosine; Wortmannin | 2005 |
Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase.
Topics: Active Transport, Cell Nucleus; Alternative Splicing; Androstadienes; Animals; beta Catenin; Blotting, Western; Cell Nucleus; Cyclin D1; Cytoplasm; Cytoskeletal Proteins; Enzyme Inhibitors; Gene Silencing; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Models, Biological; Neoplasms; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Receptor Protein-Tyrosine Kinases; RNA, Messenger; RNA, Small Interfering; Serine; Trans-Activators; Tyrosine; Wortmannin | 2005 |
c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1.
Topics: Androstadienes; Animals; Cell Line, Transformed; Cell Movement; Cell Transformation, Viral; Fibroblasts; Fluorescent Antibody Technique, Indirect; Mice; Microscopy, Confocal; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; rac1 GTP-Binding Protein; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitins; Wortmannin | 2005 |
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.
Topics: Absorption; Androstadienes; Animals; Bicarbonates; Chromones; Crosses, Genetic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heterozygote; Hypoglycemic Agents; Immunoblotting; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Models, Statistical; Morpholines; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptor, Insulin; Tyrosine; Wortmannin | 2005 |
Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts.
Topics: Androstadienes; Animals; Apoptosis; Cell Division; Cell Line, Transformed; Cell Survival; Chromones; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Morpholines; Nerve Tissue Proteins; Neurons; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Stem Cells; Tyrosine; Wortmannin | 2005 |
Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.
Topics: Actins; Agar; Androstadienes; Animals; Anoikis; Binding Sites; Cell Adhesion; Cell Cycle; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Collagen; Crk-Associated Substrate Protein; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Gelatin; Genes, Dominant; Immunoblotting; Immunoprecipitation; Laminin; Matrix Metalloproteinase 2; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Paxillin; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Talin; Time Factors; Transfection; Tyrosine; Vinculin; Wortmannin | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway.
Topics: Actins; Adenoviridae; Androstadienes; Animals; Cadherins; Calcium; Cell Adhesion; Cell Line; Cell Membrane; Cytoskeleton; Dimerization; DNA; Dogs; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Guanine Nucleotide-Releasing Factor 2; Immunoprecipitation; Mice; Microscopy, Fluorescence; Models, Genetic; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-vav; rac GTP-Binding Proteins; rap1 GTP-Binding Proteins; Signal Transduction; Time Factors; Transcriptional Activation; Transfection; Tyrosine; Wortmannin | 2006 |
Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.
Topics: Adenocarcinoma; Alkaline Phosphatase; Androstadienes; beta Catenin; Butyrates; Cell Line, Tumor; Colorectal Neoplasms; Humans; Immunohistochemistry; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Tyrosine; Wortmannin | 2006 |
Analyzing the mechanism of Rap1 activation in platelets: Rap1 activation is related to the release reaction mediated through the collagen receptor GPVI.
Topics: Androstadienes; Apyrase; Blood Platelets; Collagen; Humans; Integrin alpha2beta1; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Pyrimidines; rap1 GTP-Binding Proteins; Tyrosine; Wortmannin | 2006 |
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays | 2006 |
Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation.
Topics: Androstadienes; Benzamides; Butadienes; Extracellular Signal-Regulated MAP Kinases; Fetal Blood; Humans; Hydrogen Peroxide; Male; MAP Kinase Kinase 1; Methionine; Nitric Oxide; Nitriles; Okadaic Acid; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Recombinant Proteins; Serum Albumin, Bovine; Sperm Capacitation; Tyrosine; Wortmannin | 2006 |
CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.
Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antigens, CD; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Chloroquine; CpG Islands; Cytokines; Cytoskeleton; Dendritic Cells; Humans; I-kappa B Proteins; Interferon-alpha; Interleukin-6; Intracellular Signaling Peptides and Proteins; Macrophages; Mice; Mice, Knockout; Models, Biological; Monocytes; Myeloid Differentiation Factor 88; NF-KappaB Inhibitor alpha; Oligodeoxyribonucleotides; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-hck; Pyrazoles; Pyrimidines; Quinacrine; RNA, Small Interfering; src-Family Kinases; Syk Kinase; Toll-Like Receptor 9; Tyrosine; Wortmannin | 2006 |
Targeting of the plant vacuolar sorting receptor BP80 is dependent on multiple sorting signals in the cytosolic tail.
Topics: Amino Acid Motifs; Amino Acid Sequence; Androstadienes; Cell Membrane; Cytosol; Endocytosis; Models, Biological; Molecular Sequence Data; Nicotiana; Plant Leaves; Protein Sorting Signals; Protein Transport; Receptors, Cell Surface; Recombinant Fusion Proteins; Tyrosine; Vacuoles; Vesicular Transport Proteins; Wortmannin | 2006 |
Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes.
Topics: Androstadienes; Angiotensin II; Animals; Cell Membrane; Genistein; Insulin; Insulin Receptor Substrate Proteins; Liver; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tyrosine; Vasoconstrictor Agents; Wortmannin | 2006 |
Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.
Topics: Amino Acid Motifs; Amino Acid Substitution; Ammonium Chloride; Androstadienes; beta-Cyclodextrins; Cell Line; Cell Membrane; Chloride Channels; CLC-2 Chloride Channels; Endocytosis; Endosomes; Enzyme Inhibitors; Hemagglutinins; Humans; Ion Channel Gating; Kinetics; Membrane Microdomains; Membrane Potentials; Protein Transport; Recombinant Fusion Proteins; Transfection; Tyrosine; Wortmannin | 2009 |
Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.
Topics: Androstadienes; Animals; Cyclic AMP Response Element-Binding Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Indoles; Maleimides; Mice; Mice, Inbred C57BL; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; RNA, Messenger; Serine; src-Family Kinases; tau Proteins; Transcription, Genetic; Tyrosine; Wortmannin | 2011 |