tyrosine has been researched along with staurosporine aglycone in 26 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (3.85) | 18.7374 |
1990's | 15 (57.69) | 18.2507 |
2000's | 6 (23.08) | 29.6817 |
2010's | 4 (15.38) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Decker, SJ; Ohmichi, M; Pang, L; Saltiel, AR | 1 |
Beck, KD; Burton, LE; Hefti, F; Kaplan, DR; Knüsel, B; Nikolics, K; Rabin, S; Rosenthal, A; Winslow, JW | 1 |
Cleaveland, JS; Hammond, DJ; Kiener, PA; Schacter, BZ | 1 |
Berg, MM; Chao, MV; Parada, LF; Sternberg, DW | 1 |
Green, SH; Qiu, MS | 1 |
Maher, PA | 1 |
Barger, SW; Cheng, B; Mattson, MP | 1 |
Hefti, F; Isono, F; Knüsel, B; Widmer, HR | 1 |
Abraham, I; McCroskey, MC; Sampson, KE | 1 |
Dionne, CA; Forbes, ME; Glicksman, MA; Lipfert, L; Maroney, AC; Neff, NT; Siman, R | 1 |
Cáceres, A; Carri, N; DiTella, MC; Feiguin, F; Morfini, G | 1 |
Hatanaka, H; Numakawa, T; Ogura, A; Sakai, N; Yamada, M | 1 |
Hamm-Alvarez, SF; Vilalta, PM; Zhang, L | 1 |
Eshhar, N; Fisher, A; Haring, R; Heldman, E; Kloog, Y; Marciano, D; Pittel, Z; Zuckerman, A | 1 |
Hioki, K; Kameshita, I; Mohri, T; Suzuki, S; Takatani, S; Tokunaga, R | 1 |
Chung, CH; Kang, MS; Kim, C; Kim, D; Kwon, H; Lee, KH; Lee, SH; Rhee, S | 1 |
Appleyard, SM; Chavkin, C; Pattillo, A; Rogalski, SL; Terman, GW | 1 |
Bachis, A; Mocchetti, I; Rabin, SJ | 1 |
Mallei, A; Mocchetti, I; Rabin, SJ | 1 |
Cristiani, C; Isacchi, A; Kalisz, HM; Knapp, S; Perego, R; Rusconi, L; Schiering, N | 1 |
Campenot, RB; Mok, SA | 1 |
Fukami, Y; Mammadova, G; Sato, K; Song, RX; Yamamoto, N | 1 |
Endoh, K; Fukushima, H; Hasegawa, S; Iwamoto, T; Josselyn, SA; Kida, S; Maeda, R; Mamiya, N; Mercaldo, V; Mukawa, T; Ohta, M; Okano, E; Shang, Y; Suzuki, A; Toyoda, H; Wu, LJ; Xu, H; Zhang, Y; Zhao, MG; Zhuo, M | 1 |
Carreno, FR; Frazer, A; Furmaga, H | 1 |
Chang, YC; Gan, Y; Huang, Y; Jin, Y; Kerrigan, JF; Li, GH; Semaan, S; Wu, J | 1 |
Gu, QY; Jiang, B; Ni, YF; Wang, FY; Wang, H; Wang, JL; Wang, YJ | 1 |
26 other study(ies) available for tyrosine and staurosporine aglycone
Article | Year |
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Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase.
Topics: Alkaloids; Carbazoles; Cell Line, Transformed; Humans; Indole Alkaloids; Nerve Growth Factors; Oncogene Proteins; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Indole Alkaloids; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurons, Afferent; Neurotrophin 3; Pheochromocytoma; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Rats; Receptor, trkA; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1992 |
A microtiter-based assay for the detection of protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaloids; Antibodies; Autoanalysis; Binding, Competitive; Carbazoles; Enzyme Stability; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Indole Alkaloids; Muramidase; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine | 1990 |
K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.
Topics: Animals; Carbazoles; Electrophoresis, Polyacrylamide Gel; Indole Alkaloids; Nerve Growth Factors; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Receptor, trkA; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation.
Topics: Animals; Carbazoles; Epidermal Growth Factor; Genistein; Guanosine Diphosphate; Guanosine Triphosphate; Indole Alkaloids; Isoflavones; Kinetics; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Tyrosine | 1991 |
Role of protein tyrosine phosphorylation in the NGF response.
Topics: Actin Cytoskeleton; Animals; Carbazoles; Cell Differentiation; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Indole Alkaloids; Insulin; Microscopy, Fluorescence; Microtubules; Nerve Growth Factors; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1989 |
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Glucose; Hippocampus; Homeostasis; Indole Alkaloids; Neurons; Phosphorylation; Phosphotyrosine; Rats; Septum Pellucidum; Staurosporine; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine | 1993 |
K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.
Topics: Carbazoles; Cell Adhesion Molecules; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indole Alkaloids; Integrins; Neurites; Neuroblastoma; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1995 |
Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons.
Topics: Acetylation; Animals; Axons; Carbazoles; Cell Polarity; Cell Survival; Cells, Cultured; CHO Cells; Ciliary Neurotrophic Factor; Cricetinae; Dose-Response Relationship, Drug; Hippocampus; Indole Alkaloids; Microtubules; Morphogenesis; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurotrophin 3; Protein Processing, Post-Translational; Pyramidal Cells; Rats; Recombinant Proteins; Stimulation, Chemical; Tubulin; Tyrosine | 1994 |
BDNF potentiates spontaneous Ca2+ oscillations in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Indole Alkaloids; Isoenzymes; Male; Microscopy, Confocal; Neuronal Plasticity; Neurons; Neuroprotective Agents; Periodicity; Phospholipase C gamma; Phosphorylation; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, Nerve Growth Factor; Synapses; Type C Phospholipases; Tyrosine | 1997 |
A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments.
Topics: Acetylation; Animals; Carbazoles; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Indole Alkaloids; Intermediate Filaments; Kidney; Microtubules; Okadaic Acid; Paclitaxel; Phosphoprotein Phosphatases; Phosphorylation; Tyrosine; Vimentin | 1998 |
Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion.
Topics: Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Drug Synergism; Enzyme Inhibitors; Indole Alkaloids; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Receptors, Muscarinic; Tyrosine | 1998 |
Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A.
Topics: Adenocarcinoma; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cyclosporine; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosuppressive Agents; Indole Alkaloids; Indoles; Integrins; Neoplasm Metastasis; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Sulfonamides; Tacrolimus; Tumor Cells, Cultured; Tyrosine | 1998 |
Promotion of skeletal muscle differentiation by K252a with tyrosine phosphorylation of focal adhesion: a possible involvement of small GTPase Rho.
Topics: Animals; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP Phosphohydrolases; Indole Alkaloids; Mice; Muscle, Skeletal; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine | 1999 |
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
Topics: Amino Acid Sequence; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genistein; GTP-Binding Proteins; Indole Alkaloids; Indoles; Lysine; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Receptor, trkB; RNA, Messenger; Staurosporine; Tyrosine; Xenopus | 2000 |
Gangliosides activate Trk receptors by inducing the release of neurotrophins.
Topics: 3T3 Cells; Animals; Carbazoles; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; G(M1) Ganglioside; Gangliosides; Immunoglobulin G; Indole Alkaloids; Mice; Nerve Growth Factors; Neurons; Phosphorylation; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, trkA; Signal Transduction; Sphingosine; Time Factors; Transfection; Tyrosine | 2002 |
Autocrine regulation of nerve growth factor expression by Trk receptors.
Topics: Analysis of Variance; Animals; Autocrine Communication; Blotting, Northern; Blotting, Western; Carbazoles; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; G(M1) Ganglioside; Gene Expression Regulation; Humans; Immunoassay; Immunoglobulin G; Indole Alkaloids; Mice; Nerve Growth Factor; Neurotrophin 3; NIH 3T3 Cells; Phosphorylation; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; Recombinant Proteins; RNA, Messenger; Time Factors; Transfection; Tyrosine | 2004 |
Regulation of the wild-type and Y1235D mutant Met kinase activation.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Carbazoles; Enzyme Inhibitors; Gene Silencing; Humans; Indole Alkaloids; Kinetics; Mutation; Neoplasm Metastasis; Phenotype; Phosphorylation; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Transduction, Genetic; Tumor Cells, Cultured; Tyrosine | 2005 |
A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA.
Topics: Animals; Animals, Newborn; Axons; Blotting, Western; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Indole Alkaloids; Indoles; Nerve Growth Factor; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkA; Serine; Signal Transduction; Superior Cervical Ganglion; Tyrosine | 2007 |
Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.
Topics: Amino Acid Sequence; Apoptosis; Carbazoles; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Enzyme Activation; ErbB Receptors; Hepatocyte Growth Factor; Humans; Indole Alkaloids; Indoles; Molecular Sequence Data; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-met; Signal Transduction; src-Family Kinases; Sulfonamides; Tyrosine; Tyrphostins; Urinary Bladder Neoplasms | 2006 |
Upregulation of CREB-mediated transcription enhances both short- and long-term memory.
Topics: Analysis of Variance; Animals; Bacterial Proteins; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Carbazoles; Cell Line, Transformed; Chlorocebus aethiops; Conditioning, Classical; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Discrimination, Psychological; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fear; Fluorescence Resonance Energy Transfer; Hippocampus; Indole Alkaloids; Long-Term Potentiation; Luminescent Proteins; Maze Learning; Memory, Long-Term; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Patch-Clamp Techniques; Phenylalanine; Rats; RNA, Messenger; Social Behavior; Transfection; Tyrosine; Up-Regulation | 2011 |
Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain.
Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Western; Brain; Carbazoles; Desipramine; Enzyme Inhibitors; Fluoxetine; Hippocampus; Indole Alkaloids; Male; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Selective Serotonin Reuptake Inhibitors; Time Factors; Tyrosine; Vagus Nerve; Vagus Nerve Stimulation | 2012 |
Hyperactivation of BDNF-TrkB signaling cascades in human hypothalamic hamartoma (HH): a potential mechanism contributing to epileptogenesis.
Topics: Adolescent; Adult; Brain-Derived Neurotrophic Factor; Carbazoles; Child; Child, Preschool; Down-Regulation; Enzyme Inhibitors; Female; Hamartoma; Humans; Hypothalamic Diseases; Hypothalamus; In Vitro Techniques; Indole Alkaloids; Infant; K Cl- Cotransporters; Male; Membrane Glycoproteins; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phosphorylation; Protein-Tyrosine Kinases; Receptor, trkB; Signal Transduction; Symporters; Tyrosine; Young Adult | 2015 |
Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbazoles; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Gemfibrozil; Hippocampus; Immobility Response, Tonic; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Motor Activity; Oxazoles; Protein-Tyrosine Kinases; RNA, Small Interfering; Serotonin; Signal Transduction; Tyrosine | 2018 |