tyrosine and staurosporine aglycone

tyrosine has been researched along with staurosporine aglycone in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's15 (57.69)18.2507
2000's6 (23.08)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Decker, SJ; Ohmichi, M; Pang, L; Saltiel, AR1
Beck, KD; Burton, LE; Hefti, F; Kaplan, DR; Knüsel, B; Nikolics, K; Rabin, S; Rosenthal, A; Winslow, JW1
Cleaveland, JS; Hammond, DJ; Kiener, PA; Schacter, BZ1
Berg, MM; Chao, MV; Parada, LF; Sternberg, DW1
Green, SH; Qiu, MS1
Maher, PA1
Barger, SW; Cheng, B; Mattson, MP1
Hefti, F; Isono, F; Knüsel, B; Widmer, HR1
Abraham, I; McCroskey, MC; Sampson, KE1
Dionne, CA; Forbes, ME; Glicksman, MA; Lipfert, L; Maroney, AC; Neff, NT; Siman, R1
Cáceres, A; Carri, N; DiTella, MC; Feiguin, F; Morfini, G1
Hatanaka, H; Numakawa, T; Ogura, A; Sakai, N; Yamada, M1
Hamm-Alvarez, SF; Vilalta, PM; Zhang, L1
Eshhar, N; Fisher, A; Haring, R; Heldman, E; Kloog, Y; Marciano, D; Pittel, Z; Zuckerman, A1
Hioki, K; Kameshita, I; Mohri, T; Suzuki, S; Takatani, S; Tokunaga, R1
Chung, CH; Kang, MS; Kim, C; Kim, D; Kwon, H; Lee, KH; Lee, SH; Rhee, S1
Appleyard, SM; Chavkin, C; Pattillo, A; Rogalski, SL; Terman, GW1
Bachis, A; Mocchetti, I; Rabin, SJ1
Mallei, A; Mocchetti, I; Rabin, SJ1
Cristiani, C; Isacchi, A; Kalisz, HM; Knapp, S; Perego, R; Rusconi, L; Schiering, N1
Campenot, RB; Mok, SA1
Fukami, Y; Mammadova, G; Sato, K; Song, RX; Yamamoto, N1
Endoh, K; Fukushima, H; Hasegawa, S; Iwamoto, T; Josselyn, SA; Kida, S; Maeda, R; Mamiya, N; Mercaldo, V; Mukawa, T; Ohta, M; Okano, E; Shang, Y; Suzuki, A; Toyoda, H; Wu, LJ; Xu, H; Zhang, Y; Zhao, MG; Zhuo, M1
Carreno, FR; Frazer, A; Furmaga, H1
Chang, YC; Gan, Y; Huang, Y; Jin, Y; Kerrigan, JF; Li, GH; Semaan, S; Wu, J1
Gu, QY; Jiang, B; Ni, YF; Wang, FY; Wang, H; Wang, JL; Wang, YJ1

Other Studies

26 other study(ies) available for tyrosine and staurosporine aglycone

ArticleYear
Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase.
    Biochemistry, 1992, Apr-28, Volume: 31, Issue:16

    Topics: Alkaloids; Carbazoles; Cell Line, Transformed; Humans; Indole Alkaloids; Nerve Growth Factors; Oncogene Proteins; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine

1992
K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.
    Journal of neurochemistry, 1992, Volume: 59, Issue:2

    Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Indole Alkaloids; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurons, Afferent; Neurotrophin 3; Pheochromocytoma; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Rats; Receptor, trkA; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tyrosine

1992
A microtiter-based assay for the detection of protein tyrosine kinase activity.
    Analytical biochemistry, 1990, Nov-01, Volume: 190, Issue:2

    Topics: Adenosine Triphosphate; Alkaloids; Antibodies; Autoanalysis; Binding, Competitive; Carbazoles; Enzyme Stability; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Indole Alkaloids; Muramidase; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Staurosporine; Substrate Specificity; Tyrosine

1990
K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.
    The Journal of biological chemistry, 1992, Jan-05, Volume: 267, Issue:1

    Topics: Animals; Carbazoles; Electrophoresis, Polyacrylamide Gel; Indole Alkaloids; Nerve Growth Factors; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Rats; Receptor, trkA; Signal Transduction; Tumor Cells, Cultured; Tyrosine

1992
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation.
    Neuron, 1991, Volume: 7, Issue:6

    Topics: Animals; Carbazoles; Epidermal Growth Factor; Genistein; Guanosine Diphosphate; Guanosine Triphosphate; Indole Alkaloids; Isoflavones; Kinetics; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Tyrosine

1991
Role of protein tyrosine phosphorylation in the NGF response.
    Journal of neuroscience research, 1989, Volume: 24, Issue:1

    Topics: Actin Cytoskeleton; Animals; Carbazoles; Cell Differentiation; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Indole Alkaloids; Insulin; Microscopy, Fluorescence; Microtubules; Nerve Growth Factors; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates

1989
Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.
    Journal of neurochemistry, 1994, Volume: 62, Issue:4

    Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Glucose; Hippocampus; Homeostasis; Indole Alkaloids; Neurons; Phosphorylation; Phosphotyrosine; Rats; Septum Pellucidum; Staurosporine; Tyrosine

1994
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
    Journal of neurochemistry, 1994, Volume: 63, Issue:4

    Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine

1994
Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells.
    Journal of cellular biochemistry, 1993, Volume: 52, Issue:4

    Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Calcium; Carbazoles; Carrier Proteins; Clone Cells; Cyclic AMP; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Indole Alkaloids; Indoles; KB Cells; Melanoma, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phosphatidylserines; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrroles; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine

1993
K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.
    Journal of neurochemistry, 1995, Volume: 64, Issue:2

    Topics: Carbazoles; Cell Adhesion Molecules; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indole Alkaloids; Integrins; Neurites; Neuroblastoma; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine

1995
Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons.
    Journal of neuroscience research, 1994, Oct-01, Volume: 39, Issue:2

    Topics: Acetylation; Animals; Axons; Carbazoles; Cell Polarity; Cell Survival; Cells, Cultured; CHO Cells; Ciliary Neurotrophic Factor; Cricetinae; Dose-Response Relationship, Drug; Hippocampus; Indole Alkaloids; Microtubules; Morphogenesis; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurotrophin 3; Protein Processing, Post-Translational; Pyramidal Cells; Rats; Recombinant Proteins; Stimulation, Chemical; Tubulin; Tyrosine

1994
BDNF potentiates spontaneous Ca2+ oscillations in cultured hippocampal neurons.
    Brain research, 1997, Dec-19, Volume: 778, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Indole Alkaloids; Isoenzymes; Male; Microscopy, Confocal; Neuronal Plasticity; Neurons; Neuroprotective Agents; Periodicity; Phospholipase C gamma; Phosphorylation; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, Nerve Growth Factor; Synapses; Type C Phospholipases; Tyrosine

1997
A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments.
    Journal of cell science, 1998, Volume: 111 ( Pt 13)

    Topics: Acetylation; Animals; Carbazoles; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Indole Alkaloids; Intermediate Filaments; Kidney; Microtubules; Okadaic Acid; Paclitaxel; Phosphoprotein Phosphatases; Phosphorylation; Tyrosine; Vimentin

1998
Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion.
    Journal of neurochemistry, 1998, Volume: 71, Issue:5

    Topics: Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Drug Synergism; Enzyme Inhibitors; Indole Alkaloids; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Receptors, Muscarinic; Tyrosine

1998
Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A.
    Cell structure and function, 1998, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cyclosporine; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosuppressive Agents; Indole Alkaloids; Indoles; Integrins; Neoplasm Metastasis; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Sulfonamides; Tacrolimus; Tumor Cells, Cultured; Tyrosine

1998
Promotion of skeletal muscle differentiation by K252a with tyrosine phosphorylation of focal adhesion: a possible involvement of small GTPase Rho.
    Experimental cell research, 1999, Nov-01, Volume: 252, Issue:2

    Topics: Animals; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP Phosphohydrolases; Indole Alkaloids; Mice; Muscle, Skeletal; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine

1999
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
    The Journal of biological chemistry, 2000, Aug-18, Volume: 275, Issue:33

    Topics: Amino Acid Sequence; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genistein; GTP-Binding Proteins; Indole Alkaloids; Indoles; Lysine; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Receptor, trkB; RNA, Messenger; Staurosporine; Tyrosine; Xenopus

2000
Gangliosides activate Trk receptors by inducing the release of neurotrophins.
    The Journal of biological chemistry, 2002, Dec-20, Volume: 277, Issue:51

    Topics: 3T3 Cells; Animals; Carbazoles; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; G(M1) Ganglioside; Gangliosides; Immunoglobulin G; Indole Alkaloids; Mice; Nerve Growth Factors; Neurons; Phosphorylation; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, trkA; Signal Transduction; Sphingosine; Time Factors; Transfection; Tyrosine

2002
Autocrine regulation of nerve growth factor expression by Trk receptors.
    Journal of neurochemistry, 2004, Volume: 90, Issue:5

    Topics: Analysis of Variance; Animals; Autocrine Communication; Blotting, Northern; Blotting, Western; Carbazoles; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; G(M1) Ganglioside; Gene Expression Regulation; Humans; Immunoassay; Immunoglobulin G; Indole Alkaloids; Mice; Nerve Growth Factor; Neurotrophin 3; NIH 3T3 Cells; Phosphorylation; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; Recombinant Proteins; RNA, Messenger; Time Factors; Transfection; Tyrosine

2004
Regulation of the wild-type and Y1235D mutant Met kinase activation.
    Biochemistry, 2005, Nov-01, Volume: 44, Issue:43

    Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Carbazoles; Enzyme Inhibitors; Gene Silencing; Humans; Indole Alkaloids; Kinetics; Mutation; Neoplasm Metastasis; Phenotype; Phosphorylation; Phosphotyrosine; Protein Conformation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Transduction, Genetic; Tumor Cells, Cultured; Tyrosine

2005
A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Animals; Animals, Newborn; Axons; Blotting, Western; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Indole Alkaloids; Indoles; Nerve Growth Factor; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkA; Serine; Signal Transduction; Superior Cervical Ganglion; Tyrosine

2007
Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.
    Journal of cell science, 2006, Nov-15, Volume: 119, Issue:Pt 22

    Topics: Amino Acid Sequence; Apoptosis; Carbazoles; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Enzyme Activation; ErbB Receptors; Hepatocyte Growth Factor; Humans; Indole Alkaloids; Indoles; Molecular Sequence Data; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-met; Signal Transduction; src-Family Kinases; Sulfonamides; Tyrosine; Tyrphostins; Urinary Bladder Neoplasms

2006
Upregulation of CREB-mediated transcription enhances both short- and long-term memory.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jun-15, Volume: 31, Issue:24

    Topics: Analysis of Variance; Animals; Bacterial Proteins; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Carbazoles; Cell Line, Transformed; Chlorocebus aethiops; Conditioning, Classical; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Discrimination, Psychological; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fear; Fluorescence Resonance Energy Transfer; Hippocampus; Indole Alkaloids; Long-Term Potentiation; Luminescent Proteins; Maze Learning; Memory, Long-Term; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Patch-Clamp Techniques; Phenylalanine; Rats; RNA, Messenger; Social Behavior; Transfection; Tyrosine; Up-Regulation

2011
Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Western; Brain; Carbazoles; Desipramine; Enzyme Inhibitors; Fluoxetine; Hippocampus; Indole Alkaloids; Male; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Selective Serotonin Reuptake Inhibitors; Time Factors; Tyrosine; Vagus Nerve; Vagus Nerve Stimulation

2012
Hyperactivation of BDNF-TrkB signaling cascades in human hypothalamic hamartoma (HH): a potential mechanism contributing to epileptogenesis.
    CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Brain-Derived Neurotrophic Factor; Carbazoles; Child; Child, Preschool; Down-Regulation; Enzyme Inhibitors; Female; Hamartoma; Humans; Hypothalamic Diseases; Hypothalamus; In Vitro Techniques; Indole Alkaloids; Infant; K Cl- Cotransporters; Male; Membrane Glycoproteins; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phosphorylation; Protein-Tyrosine Kinases; Receptor, trkB; Signal Transduction; Symporters; Tyrosine; Young Adult

2015
Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbazoles; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Gemfibrozil; Hippocampus; Immobility Response, Tonic; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Motor Activity; Oxazoles; Protein-Tyrosine Kinases; RNA, Small Interfering; Serotonin; Signal Transduction; Tyrosine

2018