tyrosine has been researched along with sphingosine in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 16 (47.06) | 29.6817 |
| 2010's | 5 (14.71) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Dressler, KA; Goldkorn, T; Kolesnick, RN; Liotta, D; Menaldino, D; Mendelsohn, J; Muindi, J; Radin, NS | 1 |
| Rozengurt, E; Seufferlein, T | 1 |
| Bird, TA; Gayle, M; Kyriakis, JM; Milne, A; Tyshler, L; Virca, GD | 1 |
| Bongrand, P; Bouhamdan, M; Capo, C; Huang, CK; Mege, JL; Sanguedolce, MV | 1 |
| Asazuma, N; Hisano, N; Igarashi, Y; Kume, S; Ozaki, Y; Qi, R; Satoh, K; Yang, L; Yatomi, Y | 1 |
| Beitner-Johnson, D; Blakesley, VA; LeRoith, D; Rani, S; Shen-Orr, Z; Spiegel, S; Stannard, BS; Van Brocklyn, JR | 1 |
| Fu, W; Furukawa, K; Goodman, Y; Luo, H; Mattson, MP | 1 |
| Burl, S; Chahine, H; Damen, J; Eaves, A; Eaves, C; Krystal, G; Liu, L; Maguer-Satta, V | 1 |
| Kuan, CY; Lee, SC; Wen, ZD; Yang, SD | 1 |
| Rodríguez-Fernández, JL; Rozengurt, E | 1 |
| Bian, ZC; Guan, JL; Guo, C; Martin-Padura, I; Zheng, C | 1 |
| Nohara, K; Olivera, A; Spiegel, S; Thompson, EW; Wang, F | 1 |
| Kim, KW; Kim, YM; Kim, YS; Kwon, HJ; Kwon, YG; Lee, DJ; Lee, OH | 1 |
| Aizu-Yokota, E; Hasegawa, M; Kasahara, T; Momoi, T; Sakurai, S; Sonoda, Y; Yamamoto, D | 1 |
| Kajimoto, T; Ohmori, S; Saito, N; Sakai, N; Shirai, Y | 1 |
| Begg, D; Berthiaume, LG; Bourgoin, S; Brindley, DN; Hanna, AN; Kikuchi, Y | 1 |
| Bachis, A; Mocchetti, I; Rabin, SJ | 1 |
| Calderón, V; Reynoso, R; Salgado, LM | 1 |
| Birukov, KG; Birukova, AA; Garcia, JG; Shikata, Y; Verin, A | 1 |
| Birukov, KG; Chiang, ET; Dudek, SM; Garcia, JG; Jacobson, JR; Wang, P; Zhan, X | 1 |
| Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T; Yamaguchi, H; Yamashita, H; Yatomi, Y | 1 |
| Ohmori, T; Osada, M; Ozaki, Y; Yatomi, Y | 1 |
| Fieger, CB; Goetzl, EJ; Huang, MC; Van Brocklyn, JR | 1 |
| Broussard, SR; Dantzer, R; Freund, GG; Johnson, RW; Kelley, KW; LeCleir, JM; McCusker, RH; Shen, WH; Strle, K | 1 |
| Kovacs, E; Liliom, K | 1 |
| Fulton, D; Li, C; Ruan, L; Sood, SG; Venema, RC; Zhang, Q | 1 |
| Gibbs, TC; Kipp, KR; Meier, KE; Rubio, MV; Xie, Y; Zhang, Z | 1 |
| Chen, SU; Huang, YL; Lee, H; Lin, HS | 1 |
| Arce, FT; Brown, ME; Camp, SM; Chiang, ET; Desai, A; Dudek, SM; Garcia, JG; Guo, Y; Imam, SZ; Lal, R; Singleton, PA; Van Eyk, JE; Wang, L; Zhao, J | 1 |
| Bittman, R; Ohotski, J; Pyne, NJ; Pyne, S; Rosen, H | 1 |
| Aguirre, A; Díaz, MI; Leyton, L; Llanos, P; Mc Master, C; Ortiz, R; Quest, AF; Valenzuela, M; Wehinger, S | 1 |
| Chavez, A; Desai, B; Giantsos-Adams, K; Knezevic, N; Malik, AB; Mehta, D; Rajput, C; Schmidt, TT; Sukriti, S; Yazbeck, P | 1 |
| Elias, PM; Jeon, JE; Jeong, SK; Kim, BW; Kim, HJ; Kim, YI; Lee, SH; Lee, YM; Mauro, TM; Park, K; Shin, KO; Uchida, Y | 1 |
| Banday, ZZ | 1 |
1 review(s) available for tyrosine and sphingosine
| Article | Year |
|---|---|
Tyrosine phosphorylation in the action of neuropeptides and growth factors.
Topics: Animals; Cell Adhesion Molecules; Cell Division; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Humans; Lysophospholipids; Neuropeptides; Paxillin; Phosphoproteins; Phosphorylation; Phosphorylcholine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Sphingosine; Tyrosine | 1997 |
33 other study(ies) available for tyrosine and sphingosine
| Article | Year |
|---|---|
Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action.
Topics: Autoradiography; Blotting, Western; Carcinoma, Squamous Cell; Ceramides; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Humans; Peptide Mapping; Phosphorylation; Signal Transduction; Sphingosine; Tumor Cells, Cultured; Tyrosine | 1991 |
Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Animals; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intercellular Junctions; Mice; Molecular Weight; Paxillin; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Sphingosine; Terpenes; Thapsigargin; Tyrosine | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Zymosan-induced tyrosine phosphorylations in human monocytes. Role of protein kinase C.
Topics: Catechols; Genistein; Humans; In Vitro Techniques; Isoflavones; Molecular Weight; Monocytes; Naphthalenes; Nitriles; Phosphoproteins; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine; Tyrphostins; Vanadium; Zymosan | 1993 |
Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate.
Topics: Blood Platelets; Enzyme Activation; Enzyme Precursors; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Phosphorylation; Platelet Activation; Protein-Tyrosine Kinases; Sphingosine; Syk Kinase; Tyrosine | 1996 |
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; GRB2 Adaptor Protein; Lysophospholipids; Mice; Phosphorylation; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Sphingosine; src Homology Domains; Tyrosine | 1997 |
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.
Topics: Animals; Apoptosis; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hippocampus; Lipid Peroxidation; Neurons; NF-kappa B; Nitrates; Nitrogen Compounds; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sphingosine; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 1997 |
BCR-ABL accelerates C2-ceramide-induced apoptosis.
Topics: Apoptosis; Cell Division; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine | 1998 |
The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway.
Topics: Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Carcinoma, Squamous Cell; Enzyme Activation; Enzyme Induction; Genistein; Glycogen Synthase Kinase 3; Humans; Phosphorylation; Phosphotyrosine; Protein Kinase C; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1998 |
Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Focal Adhesion Kinase 2; Lysophospholipids; Phosphorylation; Protein-Tyrosine Kinases; Rats; Sphingosine; Tyrosine | 1998 |
Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.
Topics: Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Cell Movement; Chemotaxis; Collagen; Cytoskeletal Proteins; Drug Combinations; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gelatinases; Humans; Laminin; Lysophospholipids; Matrix Metalloproteinase 2; Metalloendopeptidases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Sphingosine; Tumor Cells, Cultured; Tyrosine | 1999 |
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway.
Topics: Cell Adhesion Molecules; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Sphingosine; Type C Phospholipases; Tyrosine | 2000 |
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 6; Caspases; Cell Death; Cell Survival; Cysteine Proteinase Inhibitors; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Etoposide; Fingolimod Hydrochloride; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioma; Humans; Immunosuppressive Agents; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Propylene Glycols; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Time Factors; Tumor Cells, Cultured; Tyrosine; Vanadates | 2001 |
Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Cell Fractionation; Cell Line; Cell Membrane; Ceramides; CHO Cells; Cricetinae; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Golgi Apparatus; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Interferon-gamma; Isoenzymes; Luminescent Proteins; Magnesium; Phorbol Esters; Phosphatidylserines; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Tyrosine | 2001 |
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; rac GTP-Binding Proteins; ras Proteins; Rats; rhoA GTP-Binding Protein; Sphingomyelin Phosphodiesterase; Sphingosine; Stress Fibers; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Gangliosides activate Trk receptors by inducing the release of neurotrophins.
Topics: 3T3 Cells; Animals; Carbazoles; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; G(M1) Ganglioside; Gangliosides; Immunoglobulin G; Indole Alkaloids; Mice; Nerve Growth Factors; Neurons; Phosphorylation; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, trkA; Signal Transduction; Sphingosine; Time Factors; Transfection; Tyrosine | 2002 |
High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Topics: Animals; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Muscle, Skeletal; Palmitic Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptor, Insulin; Serine; Sphingosine; Tyrosine | 2003 |
Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT.
Topics: Adaptor Proteins, Signal Transducing; Cell Cycle Proteins; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; GTPase-Activating Proteins; Humans; Lysophospholipids; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Sphingosine; Thrombin; Tyrosine | 2003 |
Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase.
Topics: Actins; Blotting, Western; Cells, Cultured; Cortactin; Cytoskeleton; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Genes, Dominant; Genetic Vectors; GTP Phosphohydrolases; Humans; Lung; Lysophospholipids; Microfilament Proteins; Microscopy, Fluorescence; Myosin-Light-Chain Kinase; Oligonucleotides, Antisense; Peptides; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Transport; Sphingosine; src Homology Domains; Time Factors; Transfection; Tyrosine | 2004 |
Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells.
Topics: Blotting, Western; Cell Line, Tumor; ErbB Receptors; Humans; Lysophospholipids; Models, Biological; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins c-met; Sphingosine; Stomach Neoplasms; Transcriptional Activation; Tyrosine | 2004 |
The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Platelets; Calcium; Calcium Signaling; Collagen; Crotalid Venoms; Humans; Lectins, C-Type; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet Membrane Glycoproteins; Receptors, Thrombin; Sphingosine; Tyrosine | 2005 |
Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines.
Topics: Amino Acid Sequence; Animals; Blotting, Western; CD4-Positive T-Lymphocytes; Cell Movement; Cell Proliferation; Chemotaxis; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Humans; Immunoprecipitation; Interferon-gamma; Jurkat Cells; Lipid Metabolism; Lipids; Lymphatic Metastasis; Lymphocytes; Lysophospholipids; Mice; Models, Biological; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Tertiary; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; Sequence Homology, Amino Acid; Signal Transduction; Sphingosine; Spleen; T-Lymphocytes; Thymus Gland; Transfection; Tyrosine | 2005 |
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Topics: Animals; Anisomycin; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Kinetics; Mice; Myoblasts; Myogenin; Phosphoproteins; Phosphorylation; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Sphingosylphosphorylcholine as a novel calmodulin inhibitor.
Topics: Animals; Brain Chemistry; Calmodulin; Cattle; Liposomes; Micelles; Phosphorylcholine; Signal Transduction; Sphingosine; Tyrosine | 2008 |
Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83.
Topics: Adenosine Triphosphate; Angiopoietins; Animals; Aorta; Bradykinin; Cattle; Chlorocebus aethiops; COS Cells; Endothelial Cells; Enzyme Inhibitors; Estrogens; Humans; Kidney; Lysophospholipids; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Rats; Rats, Sprague-Dawley; Sphingosine; src-Family Kinases; Thapsigargin; Tyrosine; Vascular Endothelial Growth Factor A; Vasodilation | 2008 |
Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells.
Topics: Cell Division; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isomerism; Lysophospholipids; Male; Phosphorylation; Prostatic Neoplasms; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA, Messenger; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Tyrosine | 2009 |
Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells.
Topics: Amino Acid Sequence; Blotting, Western; Cell Movement; Cells, Cultured; Endothelial Cells; Flow Cytometry; Humans; Lysophospholipids; Molecular Sequence Data; Mutation; Recombinant Proteins; Sphingosine; Sulfur; Tyrosine; Umbilical Veins | 2009 |
Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.
Topics: Actins; Amino Acid Sequence; Binding Sites; Blotting, Western; Capillary Permeability; Caveolins; Cell Line; Cytoskeleton; Endothelial Cells; Enzyme Activation; Green Fluorescent Proteins; Humans; Lysophospholipids; Mass Spectrometry; Membrane Microdomains; Microscopy, Atomic Force; Microscopy, Confocal; Molecular Sequence Data; Myosin-Light-Chain Kinase; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-abl; RNA Interference; Sphingosine; Tyrosine | 2010 |
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine | 2014 |
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caveolin 1; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Insulin-Secreting Cells; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Microscopy, Confocal; Oxidants; Palmitates; Phosphorylation; Pyrimidines; Reactive Oxygen Species; Sphingosine; src-Family Kinases; Tyrosine | 2015 |
S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness.
Topics: Amino Acid Substitution; Cells, Cultured; Down-Regulation; Endothelial Cells; Humans; Lysophospholipids; Mutation, Missense; Phosphorylation; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Tyrosine | 2015 |
Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production.
Topics: Animals; Antimicrobial Cationic Peptides; Bacterial Physiological Phenomena; Cathelicidins; Cells, Cultured; Enzyme Activators; Enzyme Inhibitors; Epidermis; Humans; Immunity, Innate; Keratinocytes; Lysophospholipids; Mice; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); RNA, Messenger; RNA, Small Interfering; Sphingosine; Staphylococcus aureus; Tyrosine | 2015 |
S1P-S1PR1 signaling switch: a new paradigm of tyrosine phosphorylation.
Topics: Lysophospholipids; Phosphorylation; Signal Transduction; Sphingosine; Tyrosine | 2022 |