tyrosine and sapropterin

tyrosine has been researched along with sapropterin in 102 studies

Research

Studies (102)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (14.71)	18.7374
1990's	23 (22.55)	18.2507
2000's	32 (31.37)	29.6817
2010's	27 (26.47)	24.3611
2020's	5 (4.90)	2.80

Authors

Authors	Studies
Maruyama, W; Minami, M; Nagatsu, T; Naoi, M; Takahashi, A; Takahashi, T	1
Shintaku, H	1
Hossain, MA; Masserano, JM; Weiner, N	1
Kaufman, S; Pigeon, D; Ribeiro, P	1
Koshimura, K; Lee, K; Miwa, S; Ohue, T; Watanabe, Y	1
Davis, MD; Kaufman, S	4
Hyland, K; Surtees, R	1
Dissing, IC; Gerdes, AM; Güttler, F; Lou, H; Lykkelund, C; Pakkenberg, H; Rasmussen, V	1
Abou-Donia, MM; Nichol, CA; Viveros, OH; Wilson, SP; Zimmerman, TP	1
Bode, VC; McDonald, JD	1
Bracco, G; Ferraris, S; Guardamagna, O; Ponzone, A	1
Blonder, J; Cohen, BE; Normand, M; Peled, I; Quint, J; Szeinberg, A	1
Güttler, F; Lou, HC; Lykkelund, C; Niederwieser, A; Rasmussen, V	1
Hayaishi, O; Miwa, S; Watanabe, Y	1
Barchas, JD; Lazar, MA; Lockfeld, AJ; Truscott, RJ	1
Bullard, WP; Capson, TL	1
Mandell, AJ; Russo, PV	2
Lipson, A; O'Halloran, M; Potter, M; Wilken, B; Yu, J	1
Kitagawa, T; Nakabayashi, H; Owada, M	1
Green, M; Levene, MI; Lucock, MD	1
Callaghan, S; Gardner, ML; Lindsey, NJ; Schallreuter-Wood, KU; Wood, JM	1
Bjurling, P; Hartvig, P; Kihlberg, T; Långström, B; Lindner, KJ; Tani, Y; Tsukada, H; Watanabe, Y; Westerberg, G	1
Hartvig, P; Långström, B; Lindner, KJ; Tsukada, H	1
Gütlich, M; Hitzemann, K; Lemke, KR; Pittelkow, MR; Rödl, W; Schallreuter, KU; Swanson, NN; Wood, JM; Ziegler, I	1
Imamura, T; Isshiki, G; Nakajima, T; Oura, T; Sawada, Y; Shintaku, H	2
Bjurling, P; Hartvig, P; Kihlberg, T; Långström, B; Lindner, KJ; Tani, Y; Tsukada, H; Valtysson, J; Watanabe, Y; Westerberg, G	1
Beck, M; Blau, N; Matern, D	1
Daubner, SC; Fitzpatrick, PF; Hillas, PJ	1
Herrmann, FH; Hibberts, NA; Metelmann, HR; Moore, J; Panske, A; Sawatzki, J; Schallreuter, KU; Zschiesche, M	1
Carlsson, A; Fasth, KJ; Hartvig, P; Långström, B; Neu, H; Sonesson, C; Tedroff, J; Torstenson, R; Waters, N	1
Fujimoto, K; Ichinose, H; Katoh, S; Mitsui, Y; Nagatsu, T; Nonaka, T	1
Blau, N; Hoffmann, GF; Hyland, K; Penzien, JM; Renneberg, A; Thöny, B	1
Schallreuter, KU	1
Blau, N; Bonafé, L; Burlina, AB; Burlina, AP; Güttler, F; Romstad, A	1
Haramaki, N; Ikeda, H; Imaizumi, T; Kanaya, S; Murohara, T	1
Arruda, P; Castro, GM; de Nucci, G; Langone, F; Martins, ML; Muscará, MN; Papes, F; Rogério, F; Santos, LM; Teixeira, SA	1
d'Uscio, LV; Katusic, ZS; Milstien, S; Richardson, D; Smith, L	1
Maass, A; Moser, A; Scholz, J	1
Geddes, TJ; Kuhn, DM; Sadidi, M; Sakowski, SA	1
Akamine, EH; Carvalho, MH; de Britto, LR; Fortes, ZB; Franco, Mdo C; Kawamoto, EM; Muscara, MN; Nigro, D; Scavone, C; Teixeira, SA; Tostes, RC	1
Arnold, LA; Egami, K; Hyland, K; Jinnah, HA; Kasim, S	1
Coleman, CM; Neckameyer, WS	1
Chavan, B; Hafeez, I; Schallreuter, KU; Wood, JM	1
Aguado, C; Desviat, LR; Erlandsen, H; Gámez, A; Koch, R; Martínez, A; Matalon, R; Pérez, B; Pey, AL; Scriver, CR; Stevens, RC; Surendran, S; Tyring, S; Ugarte, M	1
Arakawa, S; Fujimoto, S; Haruna, Y; Horike, H; Kashihara, N; Komai, N; Makino, H; Sasaki, T; Satoh, M; Tsujioka, K	1
Wojtasek, H	1
Al-Mulla, F; Al-Saleh, E; Bitar, MS; Dhaunsi, GS; Mustafa, S; Wahid, S	1
Madeddu, P	1
Hashikabe, Y; Hattori, Y; Kase, H; Nakanishi, N; Uchida, K	1
Fossbakk, A; Haavik, J	1
Grady, J; Koch, R; Matalon, R; Michals-Matalon, K; Stevens, RC; Tyring, S	1
Bloch, W; Klotz, T; Sommer, F; Steinritz, D	1
Fox, DA; Haruna, Y; Kashihara, N; Komai, N; Morita, Y; Sakuta, T; Tomita, N; Yada, T	1
Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L	1
Brandacher, G; Hengster, P; Hermann, M; Maglione, M; Margreiter, R; Mark, W; Obrist, P; Schneeberger, S; Werner, ER; Werner-Felmayer, G	1
Assaloni, R; Ceriello, A; Da Ros, R; Piconi, L; Quagliaro, L; Szabó, C	1
Song, P; Wang, S; Wu, Y; Xu, J; Zhang, M; Zou, MH	1
Fuchs, D; Neurauter, G; Ploder, M; Roth, E; Schroecksnadel, K; Spittler, A	1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kobayashi, K; Kuroi, A; Mochizuki, S; Yoshida, K	1
Dikalov, S; Guidot, DM; Hart, CM; Jones, DP; Kleinhenz, DJ; Kline, ER; Liang, B; Sutliff, RL	1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kuroi, A; Mochizuki, S; Muragaki, Y; Tsujioka, H; Yoshida, K	1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kitabata, H; Kuroi, A; Mochizuki, S; Muragaki, Y; Takarada, S; Tanimoto, T; Tsujioka, H; Yoshida, K	1
Cooley, BC; Ionova, IA; Khanna, AK; Migrino, RQ; Pieper, GM; Vásquez-Vivar, J; Whitsett, J	1
Song, P; Wang, S; Wu, Y; Xu, J; Zou, MH	1
Huang, A; Kaley, G; Sun, D; Yang, YM	1
Alluto, A; Ferraris, S; Mussa, A; Ponzone, A; Porta, F; Spada, M	1
Holowatz, LA; Kenney, WL; Lang, JA	1
Closs, EI; Daiber, A; Förstermann, U; Habermeier, A; Lackner, KJ; Li, H; Lu, Q; Münzel, T; Oelze, M; Spanier, G; Thum, T; Torzewski, M; Xia, N	1
Danecka, MK; Eichinger, A; Fingerhut, R; Gersting, SW; Glossmann, H; Lagler, FB; Muntau, AC; Staudigl, M; Steinbacher, A; Zsifkovits, C	1
Brandacher, G; Cardini, B; Hengster, P; Hermann, M; Maglione, M; Margreiter, R; Mark, W; Oberhuber, R; Obrist, P; Pratschke, J; Schneeberger, S; Watschinger, K; Werner, ER; Werner-Felmayer, G	1
Song, P; Xu, J; Zhang, M; Zou, MH	1
Fujita, M; Ito, S; Iwasaka, T; Katano, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K	1
Fujita, M; Iwasaka, T; Jo, F; Jo, H; Kosaki, A; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K	1
Black, SM; Darragh, C; Elms, S; Fonseca, FV; Fulton, D; Kumar, S; Pardo, D; Rafikov, R	1
Ahn, JK; Choi, JH; Chung, JH; Fu, YM; Hong, YH; Joe, CO; Kim, JW; Kwak, SS; Lee, DH; Meadows, GG; Min, H; Sohn, S; Suk, J; Yang, S	1
Fujita, M; Iwasaka, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K	1
d'Uscio, LV; Katusic, ZS; Smith, LA	1
Czech, L; Farrow, KN; Gugino, SF; Lakshminrusimha, S; Russell, JA; Soares, F; Steinhorn, RH; Wedgwood, S	1
Bino, L; Kadlec, J; Klinke, A; Kubala, L; Kuchta, R; Lau, D; Lojek, A; Martiskova, H; Pekarova, M; Vasicek, O; Vrba, R	1
Blau, N; Heintz, C; Martinez, A; Thöny, B; Troxler, H	1
Gebauer, C; Hennermann, JB; Mönch, E; Roloff, S; Vetter, B; von Arnim-Baas, A	1
Blau, N; Hoffmann, GF; Kühn, AA; Opladen, T	1
Abad, E; Garcia-Dorado, D; Hernando, V; Inserte, J; Poncelas-Nozal, M; Vilardosa, Ú	1
Choi, JH; Hwang, O; Jeong, M; Joe, CO; Kim, D; Kwak, SS; Meadows, GG; Min, H; Yoon, Y	1
Almudéver, P; Cogolludo, A; Cortijo, J; De Diego, A; Milara, J; Perez-Vizcaino, F; Serrano-Mollar, A; Xaubet, A	1
Blank, RD; Hansen, KE; Ney, DM	1
Gu, X; Ye, J	1
Arnold, GL; Cohen-Pfeffer, JL; Enns, GM; Ficicioglu, C; Longo, N; Parker, S; Pridjian, G	1
Fukuda, K	1
Anikster, Y; Ben-Zeev, B; Benoist, JF; Berutti, R; Blau, N; Bruggmann, R; Cremer, K; Dorboz, I; Engels, H; Gahl, WA; Gemperle-Britschgi, C; Guarani, V; Haack, TB; Harper, JW; Heimer, G; Hoffmann, GF; Huttlin, EL; Imbard, A; Keller, I; Landau, Y; Malicdan, MCV; Marek-Yagel, D; Martinez, A; Mayatepek, E; Meili, D; Meissner, T; Meitinger, T; Mullikin, JC; Opladen, T; Paulo, JA; Pode-Shakked, B; Prokisch, H; Schiff, M; Schwartz, G; Shen, N; Strom, TM; Thöny, B; Trefz, FK; Vilboux, T; Ziv-Strasser, L	1
Angeloni, A; Blau, N; Carducci, C; Chiarotti, F; Leuzzi, V; Nardecchia, F; Santagata, S; Valentini, G	1
Campistol Plana, J	1
Anstey, NM; DeRisi, JL; Florence, SM; Granger, DL; Hyland, K; Langelier, C; Lopansri, BK; Mukemba, JP; Mwaikambo, ED; Nakielny, S; Rubach, MP; Simmons, RA; Weinberg, JB; Yeo, TW	1
Burgerhof, J; de Vries, MC; Evers, R; Heiner-Fokkema, MR; Janssen, M; van Dam, E; van Spronsen, FJ; van Wegberg, A	1
Cai, Z; Dong, N; Feng, J; Hui, H; Li, F; Liu, F; Liu, M; Liu, Z; Rao, Z; Shang, Y; Wang, Y; Xu, L; Yuan, Z	1
Capuron, L; Castanon, N; Cussotto, S; Fanet, H; Monchaux De Oliveira, C; Vancassel, S	1
Emerson, JP; Fitzpatrick, PF; Li, M; Subedi, BP	1

Reviews

4 review(s) available for tyrosine and sapropterin

Article	Year
A review of recent advances on the regulation of pigmentation in the human epidermis. Cellular and molecular biology (Noisy-le-Grand, France), 1999, Volume: 45, Issue:7 Topics: Albinism, Oculocutaneous; alpha-MSH; Biopterins; Dihydroxyphenylalanine; Enzyme Activation; Epidermis; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Intramolecular Oxidoreductases; Keratinocytes; Melanocytes; Melanosomes; Membrane Glycoproteins; Membrane Proteins; Monophenol Monooxygenase; Oxidative Stress; Oxidoreductases; Phenylalanine; Phenylalanine Hydroxylase; Pro-Opiomelanocortin; Proteins; Racial Groups; Recombinant Fusion Proteins; Skin Pigmentation; Transfection; Tyrosine; Tyrosine 3-Monooxygenase; Vitiligo	1999
Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons? Journal of neurochemistry, 2004, Volume: 89, Issue:3 Topics: Animals; Biomarkers; Biopterins; Dopamine; Humans; Neurons; Peroxynitrous Acid; Quinones; Tyrosine	2004
eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. The Journal of endocrinology, 2011, Volume: 210, Issue:3 Topics: Amino Acid Sequence; Animals; Biopterins; Cell Membrane; Dimerization; Enzyme Activation; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Quaternary; Serine; Threonine; Tyrosine	2011
Advances in the nutritional and pharmacological management of phenylketonuria. Current opinion in clinical nutrition and metabolic care, 2014, Volume: 17, Issue:1 Topics: Amino Acids; Biopterins; Bone and Bones; Caseins; Dietary Supplements; Humans; Milk Proteins; Mutation; Peptide Fragments; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Randomized Controlled Trials as Topic; Tyrosine; Whey Proteins	2014

Trials

4 trial(s) available for tyrosine and sapropterin

Article	Year
Tetrahydrobiopterin and Parkinson's disease. Acta neurologica Scandinavica, 1989, Volume: 79, Issue:6 Topics: Adult; Antiparkinson Agents; Benserazide; Biopterins; Clinical Trials as Topic; Drug Combinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine	1989
Response of patients with phenylketonuria in the US to tetrahydrobiopterin. Molecular genetics and metabolism, 2005, Volume: 86 Suppl 1 Topics: Administration, Oral; Adolescent; Adult; Biopterins; Child; Child, Preschool; Diet, Protein-Restricted; Dose-Response Relationship, Drug; Humans; Infant; Los Angeles; Mutation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Texas; Tyrosine	2005
Evaluation of tetrahydrobiopterin (BH4) as a potential therapeutic agent to treat erectile dysfunction. Asian journal of andrology, 2006, Volume: 8, Issue:2 Topics: Adolescent; Adult; Aged; Biopterins; Cross-Over Studies; Dinoprost; Double-Blind Method; Erectile Dysfunction; Humans; Immunohistochemistry; In Vitro Techniques; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Penile Erection; Penis; Tyrosine	2006
Effect of BH4 on blood phenylalanine and tyrosine variations in patients with phenylketonuria. Molecular genetics and metabolism, 2021, Volume: 133, Issue:1 Topics: Adult; Biopterins; Brain; Child; Child, Preschool; Dried Blood Spot Testing; Female; Humans; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine	2021

Other Studies

94 other study(ies) available for tyrosine and sapropterin

Article	Year
Allosteric effect of tetrahydrobiopterin cofactors on tyrosine hydroxylase activity. Life sciences, 1992, Volume: 50, Issue:1 Topics: Allosteric Regulation; Animals; Biopterins; Kinetics; Macromolecular Substances; Protein Conformation; Rats; Tumor Cells, Cultured; Tyrosine; Tyrosine 3-Monooxygenase	1992
[The metabolic basis of the hyperphenylalaninemias and tyrosinemia]. Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50, Issue:7 Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; DNA; Humans; Hydrolases; Phenylalanine; Phenylalanine Hydroxylase; Polymorphism, Restriction Fragment Length; Tyrosine; Tyrosine Transaminase	1992
Comparative effects of electroconvulsive shock and haloperidol on in vivo tyrosine hydroxylation and tetrahydrobiopterin in the brain of rats with 6-hydroxydopamine lesions. Brain research, 1992, Dec-11, Volume: 598, Issue:1-2 Topics: Animals; Biopterins; Brain; Electroshock; Haloperidol; Hydroxylation; Male; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Stress, Physiological; Tyrosine	1992
The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. The Journal of biological chemistry, 1991, Aug-25, Volume: 266, Issue:24 Topics: Animals; Biopterins; Catalysis; Dihydroxyphenylalanine; Electrophoresis, Polyacrylamide Gel; Hydrogen Peroxide; Hydroxylation; Kinetics; Phenylalanine; Pheochromocytoma; Rats; Tumor Cells, Cultured; Tyrosine; Tyrosine 3-Monooxygenase	1991
A novel action of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin, a cofactor for hydroxylases of phenylalanine, tyrosine and tryptophan: enhancement of acetylcholine release in vivo in the rat hippocampus. Neuroscience letters, 1991, Jul-08, Volume: 128, Issue:1 Topics: Acetylcholine; Animals; Biopterins; Choline; Chromatography, High Pressure Liquid; Dialysis; Hippocampus; Injections, Intraventricular; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Reserpine; Tetrodotoxin; Tryptophan; Tyrosine	1991
7-Tetrahydrobiopterin is an uncoupled cofactor for rat hepatic phenylalanine hydroxylase. FEBS letters, 1991, Jul-08, Volume: 285, Issue:1 Topics: Animals; Biopterins; Hydrogen Peroxide; Hydroxylation; Kinetics; Liver; NAD; Oxidation-Reduction; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine	1991
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:7 Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine	1990
Evidence for the formation of the 4a-carbinolamine during the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine hydroxylase. The Journal of biological chemistry, 1989, May-25, Volume: 264, Issue:15 Topics: Animals; Biopterins; Hydrogen-Ion Concentration; Kinetics; Liver; Oxidation-Reduction; Phenylalanine; Phenylalanine Hydroxylase; Rats; Spectrophotometry, Ultraviolet; Tyrosine	1989
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells. Journal of neurochemistry, 1986, Volume: 46, Issue:4 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Aminohydrolases; Animals; Biopterins; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cyclic AMP; GTP Cyclohydrolase; Pteridines; Pterins; Serotonin; Tyrosine; Tyrosine 3-Monooxygenase	1986
The tyrosine-dependent oxidation of tetrahydropterins by lysolecithin-activated rat liver phenylalanine hydroxylase. The Journal of biological chemistry, 1988, Nov-25, Volume: 263, Issue:33 Topics: Animals; Biopterins; Enzyme Activation; Kinetics; Liver; Lysophosphatidylcholines; Oxidation-Reduction; Phenylalanine Hydroxylase; Pterins; Rats; Tyrosine	1988
Hyperphenylalaninemia in the hph-1 mouse mutant. Pediatric research, 1988, Volume: 23, Issue:1 Topics: Aminohydrolases; Animals; Biopterins; Disease Models, Animal; GTP Cyclohydrolase; Half-Life; Male; Metabolic Clearance Rate; Mice; Mice, Mutant Strains; Phenylalanine; Tyrosine	1988
[Trial of indirect screening of tetrahydrobiopterin deficiency]. Pediatrie, 1987, Volume: 42, Issue:7 Topics: Amino Acid Metabolism, Inborn Errors; Biopterins; Humans; Infant; Phenylalanine; Phenylketonurias; Tyrosine	1987
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin. Israel journal of medical sciences, 1985, Volume: 21, Issue:6 Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levodopa; Male; Nervous System Diseases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine	1985
Biopterin, neopterin and tyrosine responses to combined oral phenylalanine and tetrahydrobiopterin loading tests in two normal children and in a girl with partial biopterin deficiency. Journal of inherited metabolic disease, 1985, Volume: 8 Suppl 2 Topics: Administration, Oral; Biopterins; Child; Female; Humans; Neopterin; Phenylalanine; Pteridines; Tyrosine	1985
6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain. Archives of biochemistry and biophysics, 1985, May-15, Volume: 239, Issue:1 Topics: Animals; Biopterins; Brain; Dopamine; Hydroxylation; Isomerism; Probenecid; Pteridines; Rats; Serotonin; Time Factors; Tryptophan; Tyrosine	1985
Tyrosine hydroxylase from bovine striatum: catalytic properties of the phosphorylated and nonphosphorylated forms of the purified enzyme. Journal of neurochemistry, 1982, Volume: 39, Issue:2 Topics: Animals; Biopterins; Cattle; Corpus Striatum; Hydrogen-Ion Concentration; Kinetics; Phosphorylation; Pterins; Structure-Activity Relationship; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase	1982
Steady-state kinetics of bovine striatal tyrosine hydroxylase. Molecular pharmacology, 1983, Volume: 23, Issue:1 Topics: Animals; Biopterins; Cattle; Corpus Striatum; Dopamine; Kinetics; Levodopa; Oxygen; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase	1983
A kinetic scattering approach to the non-linear instabilities of rat brain tyrosine hydroxylase preparations at several levels of tetrahydrobiopterin cofactor demonstrates evolutionary behavior characteristic of global dynamical systems. Brain research, 1984, May-14, Volume: 299, Issue:2 Topics: Animals; Biological Evolution; Biopterins; Corpus Striatum; Kinetics; Male; Models, Chemical; Pteridines; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase	1984
Metrics from nonlinear dynamics adapted for characterizing the behavior of nonequilibrium enzymatic rate functions. Analytical biochemistry, 1984, May-15, Volume: 139, Issue:1 Topics: Animals; Biopterins; Brain; Computers; Dihydroxyphenylalanine; Enzyme Activation; Enzymes; Kinetics; Models, Biological; Rats; Statistics as Topic; Tyrosine; Tyrosine 3-Monooxygenase	1984
Dihydropteridine reductase deficiency: non-response to oral tetrahydrobiopterin load test. Journal of inherited metabolic disease, 1984, Volume: 7, Issue:2 Topics: Biopterins; Female; Fibroblasts; Humans; Infant; Lymphocytes; NADH, NADPH Oxidoreductases; Phenylalanine; Phenylketonurias; Pteridines; Tyrosine	1984
A mild case of dihydropteridine reductase deficiency with residual activity in erythrocytes. Journal of inherited metabolic disease, 1984, Volume: 7, Issue:3 Topics: Biopterins; Dihydropteridine Reductase; Erythrocytes; Female; Follow-Up Studies; Humans; Infant, Newborn; NADH, NADPH Oxidoreductases; Phenylalanine; Phenylketonurias; Tyrosine	1984
Methylfolate modulates potassium evoked neuro-secretion: evidence for a role at the pteridine cofactor level of tyrosine 3-hydroxylase. Neurochemical research, 1995, Volume: 20, Issue:6 Topics: Animals; Biopterins; Cerebellum; In Vitro Techniques; Kinetics; Male; Norepinephrine; Perfusion; Potassium; Rats; Rats, Wistar; Tetrahydrofolates; Tyrosine; Tyrosine 3-Monooxygenase	1995
A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis. Biochemical and biophysical research communications, 1995, Jan-17, Volume: 206, Issue:2 Topics: Amino Acid Sequence; Animals; Basidiomycota; Binding Sites; Biopterins; Humans; Hydro-Lyases; Kinetics; Levodopa; Melanins; Mice; Molecular Sequence Data; Monophenol Monooxygenase; Phenylalanine Hydroxylase; Ranidae; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine	1995
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on in vivo L-[beta-11C]dopa turnover in the rat striatum with infusion of L-tyrosine. Journal of neural transmission. General section, 1994, Volume: 95, Issue:1 Topics: Animals; Biopterins; Carbon Radioisotopes; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Homovanillic Acid; Male; Microdialysis; Molecular Structure; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed; Tyrosine	1994
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion. Brain research, 1994, Jan-28, Volume: 635, Issue:1-2 Topics: Amines; Animals; Biopterins; Corpus Striatum; Dopamine; Extracellular Space; Infusions, Parenteral; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase	1994
Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science (New York, N.Y.), 1994, Mar-11, Volume: 263, Issue:5152 Topics: Biopterins; Cell Differentiation; Cells, Cultured; Epidermis; GTP Cyclohydrolase; Humans; Keratinocytes; Melanins; Melanocytes; Phenylalanine Hydroxylase; Tyrosine; Vitiligo	1994
Experimental research on a fetal treatment for tetrahydrobiopterin deficiency. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Adrenal Glands; Animals; Biopterins; Corpus Striatum; Dopamine; Epinephrine; Female; Fetal Blood; Guinea Pigs; Hypoxanthines; Infusions, Intravenous; Liver; Maternal-Fetal Exchange; Metabolism, Inborn Errors; Norepinephrine; Phenylalanine; Phenylketonurias; Pregnancy; Tyrosine	1993
Experimental research on a new treatment for maternal phenylketonuria(PKU). Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Biopterins; Brain; Disease Models, Animal; Female; Fetus; Guinea Pigs; Infusions, Intravenous; Liver; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Tyrosine	1993
Products of the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine hydroxylase. Archives of biochemistry and biophysics, 1993, Volume: 304, Issue:1 Topics: Animals; Biopterins; Hydrogen Peroxide; Liver; Oxidation-Reduction; Phenylalanine Hydroxylase; Rats; Tyrosine	1993
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin and infusion of L-tyrosine on the in vivo L-[beta-11C] DOPA disposition in the monkey brain. Brain research, 1996, Mar-25, Volume: 713, Issue:1-2 Topics: Animals; Antioxidants; Biopterins; Brain; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Time Factors; Tyrosine	1996
Tetrahydrobiopterin induced neonatal tyrosinaemia. European journal of pediatrics, 1996, Volume: 155, Issue:9 Topics: Alcohol Oxidoreductases; Biopterins; Case-Control Studies; Female; Humans; Infant, Newborn; Metabolism, Inborn Errors; Phosphorus-Oxygen Lyases; Tyrosine	1996
Expression and characterization of the catalytic domain of human phenylalanine hydroxylase. Archives of biochemistry and biophysics, 1997, Dec-15, Volume: 348, Issue:2 Topics: Binding Sites; Biopterins; Catalysis; Chromatography, High Pressure Liquid; Copper; Enzyme Activation; Escherichia coli; Ferrous Compounds; Humans; Iron; Kinetics; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Recombinant Proteins; Tyrosine	1997
In vivo evidence for compromised phenylalanine metabolism in vitiligo. Biochemical and biophysical research communications, 1998, Feb-13, Volume: 243, Issue:2 Topics: Adolescent; Adult; Biopterins; Cells, Cultured; Female; Gene Expression; GTP Cyclohydrolase; Humans; Hydro-Lyases; Kinetics; Male; Middle Aged; Phenylalanine; Phenylalanine Hydroxylase; RNA, Messenger; Skin; Spectrum Analysis, Raman; Tyrosine; Vitiligo	1998
Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity. Synapse (New York, N.Y.), 1998, Volume: 28, Issue:4 Topics: Animals; Biopterins; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Female; Levodopa; Macaca mulatta; Piperidines; Reference Values; Tomography, Emission-Computed; Tyrosine	1998
Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase. Biochimica et biophysica acta, 1999, May-18, Volume: 1431, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Binding Sites; Biopterins; Cloning, Molecular; DNA, Complementary; Escherichia coli; Humans; Mutagenesis, Site-Directed; Mutation; Rats; Serine; Tyrosine	1999
Variant of dihydropteridine reductase deficiency without hyperphenylalaninaemia: effect of oral phenylalanine loading. Journal of inherited metabolic disease, 1999, Volume: 22, Issue:3 Topics: Administration, Oral; Biopterins; Child; Child, Preschool; Humans; Male; Phenylalanine; Phenylketonurias; Tyrosine	1999
Treatable neurotransmitter deficiency in mild phenylketonuria. Neurology, 2001, Sep-11, Volume: 57, Issue:5 Topics: Adolescent; Antioxidants; Biogenic Monoamines; Biopterins; Female; Humans; Phenylalanine; Phenylketonurias; Tyrosine	2001
Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation. Circulation, 2001, Nov-13, Volume: 104, Issue:20 Topics: Animals; Biopterins; Blood Platelets; Coronary Thrombosis; Cyclic GMP; Dogs; Enzyme Inhibitors; Hemodynamics; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; P-Selectin; Platelet Aggregation; Superoxides; Tyrosine	2001
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. Brain research. Molecular brain research, 2002, Feb-28, Volume: 99, Issue:1 Topics: Animals; Biopterins; Brain; Calcium; Calmodulin; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Flavin-Adenine Dinucleotide; Male; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Rats; Rats, Inbred Lew; RNA, Messenger; Subcellular Fractions; Tyrosine	2002
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circulation research, 2003, Jan-10, Volume: 92, Issue:1 Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Ascorbic Acid; Biopterins; Cyclic AMP; Cyclic GMP; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; In Vitro Techniques; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Superoxides; Time; Tyrosine; Vasomotor System; Vitamin E	2003
Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase. European journal of biochemistry, 2003, Volume: 270, Issue:6 Topics: Amino Acid Sequence; Animals; Biopterins; Catalytic Domain; Dopamine; Humans; Levodopa; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phenylalanine; Phenylalanine Hydroxylase; Protein Binding; Rats; Sequence Alignment; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase	2003
Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats. The Journal of physiology, 2004, Jul-01, Volume: 558, Issue:Pt 1 Topics: Animals; Antioxidants; Biopterins; Blotting, Western; Caloric Restriction; Endothelium, Vascular; Female; Fetal Nutrition Disorders; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tyrosine; Uterus; Vasodilation	2004
Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease. Journal of inherited metabolic disease, 2004, Volume: 27, Issue:2 Topics: Animals; Biopterins; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenylalanine; Tyrosine	2004
Substrate regulation of serotonin and dopamine synthesis in Drosophila. Invertebrate neuroscience : IN, 2004, Volume: 5, Issue:2 Topics: Animals; Biopterins; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Electrophoresis, Gel, Two-Dimensional; Immunoprecipitation; Iron; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Recombinant Fusion Proteins; Serotonin; Substrate Specificity; Time Factors; Tryptophan; Tryptophan Hydroxylase; Tyrosine	2004
Regulation of tyrosinase by tetrahydropteridines and H2O2. Biochemical and biophysical research communications, 2004, Dec-24, Volume: 325, Issue:4 Topics: Binding Sites; Biopterins; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidation-Reduction; Protein Binding; Pteridines; Tyrosine	2004
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proceedings of the National Academy of Sciences of the United States of America, 2004, Nov-30, Volume: 101, Issue:48 Topics: Biopterins; Enzyme Stability; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine Hydroxylase; Phenylketonurias; Tyrosine	2004
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy. American journal of physiology. Renal physiology, 2005, Volume: 288, Issue:6 Topics: Animals; Antioxidants; Biopterins; Diabetic Nephropathies; Gene Expression Regulation, Enzymologic; Kidney Glomerulus; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine	2005
Regulation of tyrosinase by tetrahydropteridines--what is real? A comment on the work published by Wood et al. on December 24, 2004. Biochemical and biophysical research communications, 2005, Apr-15, Volume: 329, Issue:3 Topics: Animals; Binding Sites; Biopterins; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Monophenol Monooxygenase; Oxidation-Reduction; Protein Binding; Pteridines; Tyrosine	2005
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. European journal of pharmacology, 2005, Mar-21, Volume: 511, Issue:1 Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents	2005
Correction of endothelial dysfunction by tetrahydrobiopterin: new hope for the treatment of arterial hypertension? Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Angiotensin II; Animals; Antioxidants; Biopterins; Cardiomegaly; Endothelium, Vascular; Hypertension; Immunohistochemistry; Male; Myocardium; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Tyrosine; Up-Regulation	2005
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation	2005
An oxygraphic method for determining kinetic properties and catalytic mechanism of aromatic amino acid hydroxylases. Analytical biochemistry, 2005, Aug-01, Volume: 343, Issue:1 Topics: Amino Acid Substitution; Animals; Biopterins; Electrodes; Humans; Kinetics; Oxygen; Phenylalanine Hydroxylase; Phenylketonurias; Point Mutation; Tyrosine	2005
Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase. Arthritis and rheumatism, 2006, Volume: 54, Issue:6 Topics: Acetylcholine; Aldehydes; Animals; Aorta, Thoracic; Arthritis, Experimental; Biopterins; Endothelium, Vascular; In Vitro Techniques; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilation	2006
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circulation research, 2006, Jul-07, Volume: 99, Issue:1 Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine	2006
Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:7 Topics: Animals; Biopterins; Male; Mice; Mice, Inbred C57BL; Microcirculation; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Transplantation, Homologous; Tyrosine	2006
Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2007, Volume: 17, Issue:4 Topics: 8-Hydroxy-2'-Deoxyguanosine; Apoptosis; Biopterins; Caspase 3; Cells, Cultured; Deoxyguanosine; Endothelial Cells; Glucose; Humans; Hyperglycemia; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-bcl-2; Superoxides; Thenoyltrifluoroacetone; Tyrosine	2007
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation, 2007, Aug-21, Volume: 116, Issue:8 Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; GTP Cyclohydrolase; Guanosine Triphosphate; Leupeptins; Mice; Mice, Inbred C57BL; Nitrogen; Organ Culture Techniques; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species; Spin Labels; Tyrosine; Ubiquitin; Umbilical Veins	2007
Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations. Amino acids, 2008, Volume: 35, Issue:2 Topics: Adult; Aged; Biopterins; Female; Follow-Up Studies; Humans; Male; Middle Aged; Molecular Structure; Neopterin; Oxidative Stress; Phenylalanine; Phenylalanine Hydroxylase; Reproducibility of Results; Sepsis; Tyrosine; Wounds and Injuries	2008
Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit. Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:1 Topics: Acetylcholine; Angiotensin II; Animals; Biopterins; Biosensing Techniques; Blood Pressure; Calibration; Catheterization; Enzyme Inhibitors; Heart Rate; Hypoglycemic Agents; Immunohistochemistry; Male; Nitric Oxide; omega-N-Methylarginine; Pioglitazone; PPAR gamma; Rabbits; Thiazolidinediones; Tyrosine; Vasoconstrictor Agents; Vasodilator Agents	2008
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:6 Topics: Acetylcholine; Animals; Animals, Genetically Modified; Antioxidants; Aorta; Biopterins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Glutathione; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Proviruses; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Superoxides; Thiazolidines; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase	2008
Effect of pioglitazone on nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor. Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:6 Topics: Acetylcholine; Animals; Biopterins; Calibration; Catheterization; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Hypoglycemic Agents; Male; Models, Animal; Nitric Oxide; Nitroglycerin; Pioglitazone; PPAR gamma; Rabbits; Thiazolidinediones; Tyrosine; Vasodilator Agents	2008
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:3 Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Atherosclerosis; Biopterins; Blood Pressure; Drug Therapy, Combination; Endothelium, Vascular; Fumarates; Heart Rate; HSP90 Heat-Shock Proteins; Hyperlipidemias; Inflammation Mediators; Lipids; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rabbits; Renin; Tetrazoles; Tyrosine; Valine; Valsartan; Vasodilation; Vasodilator Agents	2008
Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3 Topics: Aldehydes; Animals; Apoptosis; Arginase; Biopterins; Cyclosporine; Cytokines; Echocardiography; Gene Expression; Graft Rejection; GTP Cyclohydrolase; Heart Transplantation; Heart Ventricles; Immunosuppressive Agents; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Pterins; Rats; Rats, Inbred Lew; Rats, Inbred WF; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine	2009
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3 Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Pressure; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Leupeptins; Mice; Mice, Inbred C57BL; Nitrates; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Transfection; Tyrosine; Vasodilation	2009
eNOS uncoupling and endothelial dysfunction in aged vessels. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5 Topics: Acetylcholine; Age Factors; Aging; Alcohol Oxidoreductases; Animals; Biopterins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Enzyme Stability; GTP Cyclohydrolase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Multimerization; Pterins; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents	2009
Unresponsiveness to tetrahydrobiopterin of phenylalanine hydroxylase deficiency. Metabolism: clinical and experimental, 2010, Volume: 59, Issue:5 Topics: Adolescent; Biopterins; Child; Child, Preschool; Genotype; Humans; Infant; Mutation; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Statistics, Nonparametric; Tyrosine; Young Adult	2010
Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction. The Journal of physiology, 2010, Apr-15, Volume: 588, Issue:Pt 8 Topics: Adrenergic Uptake Inhibitors; Aged; Aging; Biopterins; Dose-Response Relationship, Drug; Female; Humans; Male; Norepinephrine; Oxidative Stress; Regional Blood Flow; Skin; Tyramine; Tyrosine; Vasoconstriction; Young Adult	2010
Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1 Topics: Animals; Antioxidants; Apolipoproteins E; Biopterins; GTP Cyclohydrolase; Isoenzymes; Male; Malondialdehyde; Mice; Mice, Knockout; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stilbenes; Superoxide Dismutase; Superoxides; Tyrosine	2010
New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Biochemical pharmacology, 2010, Nov-15, Volume: 80, Issue:10 Topics: Animals; Biopterins; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Heterozygote; Mice; Mice, Mutant Strains; Mutation; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Treatment Outcome; Tyrosine	2010
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2010, Volume: 10, Issue:10 Topics: Animals; Biopterins; Cold Ischemia; Male; Mice; Mice, Inbred C57BL; Microcirculation; Models, Animal; Pancreas; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Tissue Donors; Transplantation, Isogeneic; Tyrosine	2010
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Biopterins; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme System; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Intramolecular Oxidoreductases; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Receptors, Immunologic; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference; Signal Transduction; Superoxides; Time Factors; Tyrosine	2011
Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart. Journal of molecular and cellular cardiology, 2011, Volume: 50, Issue:3 Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left	2011
Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:8 Topics: Animals; Biopterins; Cardiotonic Agents; Coenzymes; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Enzyme Inhibitors; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Pterins; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left	2011
Autophagy induction by tetrahydrobiopterin deficiency. Autophagy, 2011, Volume: 7, Issue:11 Topics: Alcohol Oxidoreductases; Animals; Autophagy; Biopterins; Child; Down-Regulation; Female; Humans; Infant; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Neuropeptides; NIH 3T3 Cells; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Proteins; Ras Homolog Enriched in Brain Protein; TOR Serine-Threonine Kinases; Tyrosine	2011
Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:5 Topics: Administration, Oral; Angiogenesis Inducing Agents; Animals; Biopterins; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; GTP Cyclohydrolase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pterins; Recovery of Function; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Ventricular Function, Left	2011
Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:6 Topics: Animals; Antioxidants; Aorta; Biopterins; Catalase; Cyclic GMP; GTP Cyclohydrolase; Hydrogen Peroxide; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Serine; Superoxide Dismutase; Superoxides; Tyrosine	2011
Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn. American journal of physiology. Lung cellular and molecular physiology, 2012, Mar-15, Volume: 302, Issue:6 Topics: Acetophenones; Animals; Animals, Newborn; Biopterins; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Hypertension, Pulmonary; Lung; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Pulmonary Artery; Reactive Oxygen Species; Sheep; Superoxides; Tyrosine; Vasoconstriction; Vasodilation	2012
New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages. TheScientificWorldJournal, 2011, Volume: 11 Topics: Animals; Arginine; Biopterins; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Macrophages; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Respiratory Burst; Superoxides; Time Factors; Tyrosine	2011
Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry. Molecular genetics and metabolism, 2012, Volume: 105, Issue:4 Topics: Animals; Biopterins; Brain; Cells, Cultured; Chlorocebus aethiops; Chromatography, Liquid; COS Cells; Humans; Isotope Labeling; Kidney; Liver; Mice; Mutation; Phenotype; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine	2012
Long-term treatment with tetrahydrobiopterin in phenylketonuria: treatment strategies and prediction of long-term responders. Molecular genetics and metabolism, 2012, Volume: 107, Issue:3 Topics: Adolescent; Biomarkers, Pharmacological; Biopterins; Child; Child, Preschool; Disease Management; Drug Administration Schedule; Female; Humans; Long-Term Care; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Prognosis; Tyrosine	2012
Pitfalls in phenylalanine loading test in the diagnosis of dopa-responsive dystonia. Molecular genetics and metabolism, 2013, Volume: 108, Issue:3 Topics: Administration, Oral; Adult; Biopterins; Diagnosis, Differential; Dystonia; Dystonic Disorders; Female; Humans; Levodopa; Metabolism, Inborn Errors; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Psychomotor Disorders; Tyrosine	2013
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling. Journal of the American Heart Association, 2013, Jan-02, Volume: 2, Issue:1 Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine	2013
Amelioration of behavioral abnormalities in BH(4)-deficient mice by dietary supplementation of tyrosine. PloS one, 2013, Volume: 8, Issue:4 Topics: Alcohol Oxidoreductases; Animals; Behavior, Animal; Biocatalysis; Biopterins; Brain; Dietary Supplements; Dopamine; Gene Knockout Techniques; Mechanistic Target of Rapamycin Complex 1; Mice; Motor Activity; Multiprotein Complexes; TOR Serine-Threonine Kinases; Tyrosine	2013
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis. Thorax, 2013, Volume: 68, Issue:10 Topics: Aged; Alcohol Oxidoreductases; Animals; Biopterins; Chromatography, High Pressure Liquid; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; GTP Cyclohydrolase; Humans; Hypertension, Pulmonary; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Pulmonary Fibrosis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Tyrosine	2013
[Interpretation of the consensus about the diagnosis and treatment of hyperphenylalaninemia]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2014, Volume: 52, Issue:6 Topics: Biopterins; Child; Consensus; Diagnosis, Differential; Humans; Infant; Infant, Newborn; Neonatal Screening; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Practice Guidelines as Topic; Severity of Illness Index; Tyrosine	2014
Long-term safety and efficacy of sapropterin: the PKUDOS registry experience. Molecular genetics and metabolism, 2015, Volume: 114, Issue:4 Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Diet; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Phenylalanine; Phenylketonurias; Registries; Time Factors; Tyrosine; Young Adult	2015
Integrated theory to unify status among schizophrenia and manic depressive illness. Medical hypotheses, 2015, Volume: 85, Issue:4 Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biopterins; Bipolar Disorder; Blood-Brain Barrier; Depression; Depression, Postpartum; Dopamine; Female; Hallucinations; Humans; Kynurenic Acid; Levodopa; Male; Neuroleptic Malignant Syndrome; Neurotransmitter Agents; Paranoid Disorders; Premenstrual Syndrome; Schizophrenia; Seasonal Affective Disorder; Serotonin; Serotonin Syndrome; Tyrosine	2015
Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability. American journal of human genetics, 2017, 02-02, Volume: 100, Issue:2 Topics: Alleles; Amino Acid Sequence; Biopterins; Case-Control Studies; Dopamine; Dystonia; Exons; Female; Fibroblasts; Gene Deletion; Genome-Wide Association Study; HSP70 Heat-Shock Proteins; Humans; Intellectual Disability; Male; Pedigree; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Repressor Proteins; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase	2017
Altered tetrahydrobiopterin metabolism in patients with phenylalanine hydroxylase deficiency. European journal of pediatrics, 2017, Volume: 176, Issue:7 Topics: Adolescent; Adult; Biomarkers; Biopterins; Case-Control Studies; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Multivariate Analysis; Neopterin; Phenylalanine; Phenylketonurias; Retrospective Studies; Tyrosine; Young Adult	2017
[Early diagnosis of phenylketonuria. Physiopathology of the neuronal damage and therapeutic options]. Medicina, 2019, Volume: 79 Suppl 3 Topics: Biopterins; Diet Therapy; Early Diagnosis; Humans; Neurons; Phenylalanine; Phenylketonurias; Tyrosine	2019
Cerebrospinal Fluid Pterins, Pterin-Dependent Neurotransmitters, and Mortality in Pediatric Cerebral Malaria. The Journal of infectious diseases, 2021, 10-28, Volume: 224, Issue:8 Topics: Biopterins; Central Nervous System Diseases; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Malaria, Cerebral; Male; Neopterin; Neurotransmitter Agents; Prospective Studies; Pterins; Reference Values; Tanzania; Tyrosine	2021
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification. European heart journal, 2022, 05-01, Volume: 43, Issue:17 Topics: Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Biopterins; Calcinosis; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Endothelial Cells; GTP Cyclohydrolase; Humans; Mice; Peroxynitrous Acid; Tyrosine	2022
Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice. Brain, behavior, and immunity, 2022, Volume: 105 Topics: Animals; Biopterins; Cytokines; Inflammation; Lipopolysaccharides; Mice; Phenylalanine; Tyrosine	2022
Thermodynamics of iron, tetrahydrobiopterin, and phenylalanine binding to phenylalanine hydroxylase from Chromobacterium violaceum. Archives of biochemistry and biophysics, 2022, Oct-30, Volume: 729 Topics: Biopterins; Chromobacterium; Ferrous Compounds; Iron; Kinetics; Metalloproteins; Phenylalanine; Phenylalanine Hydroxylase; Pterins; Thermodynamics; Tyrosine	2022