tyrosine has been researched along with pd 98059 in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (29.67) | 18.2507 |
| 2000's | 61 (67.03) | 29.6817 |
| 2010's | 3 (3.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heumann, R; Klinz, FJ; Wolff, P | 1 |
| Freissmuth, M; Gloria-Maercker, E; Höller, C; Mancusi, G; Schütz, W; Sexl, V | 1 |
| Bitar, R; Dackiw, AP; Davreux, CJ; Lu, Z; McGilvray, ID; Rotstein, OD | 1 |
| DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J | 1 |
| Akabane, M; Ikebuchi, Y; Ikegami, H; Kanzaki, T; Kimura, A; Kobayashi, Y; Koike, K; Masuhara, K; Miyake, A; Murata, Y; Ohmichi, M; Sakaue, M; Touhara, K | 1 |
| Ceresa, BP; Horvath, CM; Pessin, JE | 1 |
| Matsutani, A; Oka, Y; Okuya, S; Tanabe, K; Tanizawa, Y | 1 |
| Bitangcol, JC; Chau, AS; Dicken, B; Lohka, MJ; Shibuya, EK; Stadnick, E | 1 |
| Baldi, E; Barni, T; Forti, G; Krausz, C; Luconi, M; Vannelli, GB | 1 |
| Anand-Srivastava, MB; Pandey, SK; Srivastava, AK | 1 |
| Daulton, AA; Djeu, JY; Gamero, AM; Larner, AC; Liu, JH; Trapani, JA; Valkov, NI; Weber, MJ; Wei, S | 1 |
| Baldi, E; Barni, T; Benedetti, PA; Evangelista, V; Forti, G; Francavilla, S; Krausz, C; Luconi, M; Marra, F; Properzi, G; Vannelli, GB | 1 |
| Frasca, F; Giorgino, F; Gliozzo, B; Goldfine, ID; Milazzo, G; Papa, V; Pezzino, V; Scalia, P; Sciacca, L; Sung, CK; Vigneri, R | 1 |
| Conn, PJ; Peavy, RD | 1 |
| Feldman, EL; Kim, B | 1 |
| Chernausek, SD; Coolican, SA; Ewton, DZ; Florini, JR; Mohan, S | 1 |
| Rosales, C; Sánchez-Mejorada, G | 1 |
| Hato, F; Hino, M; Kitagawa, S; Suzuki, K; Tatsumi, N | 1 |
| Waxman, DJ; Zhou, YC | 1 |
| Deng, LY; He, G; Schiffrin, EL; Touyz, RM | 1 |
| Marshall, CJ; Rausch, O | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| DeFea, K; Li, J; Roth, RA | 1 |
| Bonavida, B; Mori, S; Murakami-Mori, K; Nakamura, S | 1 |
| Burdon, T; Chambers, I; Nichols, J; Smith, A; Stracey, C | 1 |
| Banfi, C; Battaini, F; Cattaneo, MG; Galli, C; Mussoni, L; Risé, P; Tremoli, E; Vicentini, L | 1 |
| Haugh, JM; Huang, AC; Lauffenburger, DA; Wells, A; Wiley, HS | 1 |
| Sánchez-Margalet, V | 1 |
| Bradshaw, RA; Wu, YY | 1 |
| Strayer, DS; White, MK | 1 |
| Arnould, T; Michel, G; Michiels, C; Minet, E; Mottet, D; Raes, M; Remacle, J; Roland, I | 1 |
| Bertics, PJ; Guadarrama, AG; Kim, YN; Wiepz, GJ | 1 |
| Leopoldt, D; Rozengurt, E; Saab, S; Yee, HF | 1 |
| Anderson, KC; Chauhan, D; Hideshima, T; Raje, N; Shima, Y; Tai, YT; Teoh, G; Treon, SP | 1 |
| Fleck, E; Goetze, S; Hsueh, WA; Kawano, H; Kawano, Y; Kintscher, U; Law, RE; Wakino, S | 1 |
| Hazan-Halevy, I; Levy, R; Seger, R | 1 |
| Chikazu, D; Hakeda, Y; Itabashi, A; Kawaguchi, H; Kumegawa, M; Nakamura, K; Nemoto, K; Ogata, N; Takato, T | 1 |
| Bellacosa, A; Billaud, M; Carlomagno, F; Castellone, MD; De Vita, G; Fusco, A; Melillo, RM; Santoro, M; Tsichlis, PN; Visconti, R | 1 |
| Li, Y; Liu, J; Zhan, X | 1 |
| Bogoyevitch, MA; Ng, DC | 1 |
| Horwitz, SB; Yang, CP | 1 |
| Bertics, PJ; Chun, TY; Gorski, J; Kim, YN; Watters, JJ | 1 |
| Chikazu, D; Hakeda, Y; Katagiri, M; Kawaguchi, H; Kumegawa, M; Nakamura, K; Ogasawara, T; Takato, T | 1 |
| Carvalho, NB; Raulais, D; Souttou, B; Vigny, M | 1 |
| Brake, DK; Cengel, KA; Deszo, EL; Freund, GG; Kelley, KW | 1 |
| Fukuda, A; Ikeda, M; Morita, M; Shimada, Y; Takagi, M | 1 |
| Hermanto, U; Wang, LH; Zong, CS | 1 |
| Fennelly, C; Krause, D; Lyons, A; O'Connor, R | 1 |
| Berrou, E; Bryckaert, M | 1 |
| Bisotto, S; Fixman, ED | 1 |
| Chihara, K; Iida, K; Kaji, H; Kangawa, K; Kojima, M; Matsumoto, M; Murata, M; Okimura, Y; Sowa, H | 1 |
| Iwabuchi, K; Koyama, Y; Minami, A; Nishihira, J; Onodera, S; Tanaka, S; Yoshida, K | 1 |
| Bryson, JM; Coy, PE; Ma, J; Noboa, OA; Robey, RB; Santos, AV | 1 |
| Horiguchi, A; Marumo, K; Murai, M; Oya, M | 1 |
| Fan, YP; Puri, RN; Rattan, S | 1 |
| de Lamirande, E; Gagnon, C; Thundathil, J | 1 |
| Bertics, PJ; Dam, P; Kim, YN | 1 |
| Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Castellone, MD; Cirafici, AM; De Falco, V; De Vita, G; Fagin, JA; Fusco, A; Malorni, L; Melillo, RM; Santoro, M; Tallini, G | 1 |
| Hill, MA; Martinez-Lemus, LA; Meininger, GA; Potocnik, SJ | 1 |
| Andersson, TP; Karlsson, AM; Svensson, SP | 1 |
| Coss, D; Kuo, CB; Lorenson, MY; Walker, AM; Wu, W; Xu, X | 1 |
| Dong, J; Ivanov, VN; Krasilnikov, M; Ronai, Z | 1 |
| Kracklauer, MP; Schmidt, C; Sclabas, GM | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Kruger, JS; Reddy, KB | 1 |
| Barrett, KE; Carlstrom, K; Chow, JY | 1 |
| Ishikawa, K; Tokumoto, T; Watanabe, K | 1 |
| Barrett, KE; Bertelsen, LS; Keely, SJ | 1 |
| Naruishi, K; Nishimura, F; Omori, K; Takashiba, S; Yamada-Naruishi, H | 1 |
| Lu, Y; Pollak, M; Zhao, Y; Zi, X | 1 |
| Abe, T; Degawa-Yamauchi, M; Eguchi, K; Fujita, N; Fukushima, T; Ishida-Takahashi, R; Sakamaki, H; Uotani, S; Yamaguchi, Y; Yamasaki, H | 1 |
| Bitar, KN; Cheng, HL; Christman, GM; Hou, YT; Li, L; Schmiedlin-Ren, P; Xin, X; Zimmermann, EM | 1 |
| Boutahar, N; Guignandon, A; Lafage-Proust, MH; Vico, L | 1 |
| Devaux, Y; Pan, ZZ; Ray, P | 1 |
| Chang, NS; Heath, J; Hsu, LJ; Jambal, P; Pugazhenthi, S; Schultz, L; Su, M; Sze, CI | 1 |
| Fujimoto, J; Kotani, M; Motegi, A; Sakuraba, H; Yamamoto, T | 1 |
| Hayashi, K; Iwasaki, K; Morita, T; Shibata, K; Sobue, K; Watanabe, M | 1 |
| Han, S; Rivera, HN; Roman, J | 1 |
| Li, SN; Miyazu, M; Naruse, K; Sokabe, M; Wang, JG; Xiang, P | 1 |
| Carr, BI; Ham, SW; Kar, S; Peyregne, VP; Wang, M; Wang, Z | 1 |
| Du, L; Kim, LT; Nwariaku, FE; Panta, GR | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Frank, SJ; Franklin, JL; Keeton, AB; Li, X; Messina, JL; Venable, DY; Xu, J | 1 |
| Basson, MD; Chaturvedi, LS; Marsh, HM | 1 |
| Chao, HH; Chen, YL; Cheng, TH; Chiu, WT; Hong, HJ; Lin, JW; Liu, JC; Shyu, KG; Wu, CH | 1 |
| Chao, HP; Fu, SL; Kuo, CD; Liang, FP; Lin, CH | 1 |
| Hau, CS; Ishikawa, T; Kanda, N; Tada, Y; Watanabe, S | 1 |
| Bramanti, P; Cuzzocrea, S; Di Paola, R; Galuppo, M; Mazzon, E; Paterniti, I | 1 |
| Cuzzocrea, S; Di Paola, R; Esposito, E; Galuppo, M; Impellizzeri, D; Mazzon, E; Paterniti, I | 1 |
| Chen, S; Huang, J; Huang, Q; Liu, B; Liu, P; Luo, J; Pan, X; Zang, L; Zeng, Z; Zhou, S | 1 |
91 other study(ies) available for tyrosine and pd 98059
| Article | Year |
|---|---|
Nerve growth factor-stimulated mitogen-activated protein kinase activity is not necessary for neurite outgrowth of chick dorsal root ganglion sensory and sympathetic neurons.
Topics: Animals; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Flavonoids; Ganglia, Spinal; Ganglia, Sympathetic; Male; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogens; Nerve Growth Factors; Neurites; Neurons, Afferent; Peripheral Nerves; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1996 |
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Humans; Isoproterenol; Phosphorylation; Receptors, Purinergic P1; Thymidine; Tyrosine; Vasodilator Agents | 1997 |
VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Fibronectins; Flavonoids; Genistein; Humans; Integrin alpha4beta1; Integrin beta1; Integrins; Isoflavones; NF-kappa B; Nuclear Proteins; Phosphorylation; Receptors, Lymphocyte Homing; Receptors, Very Late Antigen; Thromboplastin; Trans-Activators; Tyrosine; Viral Proteins; Zinc Fingers | 1997 |
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1997 |
Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dinoprost; Enzyme Activation; Female; Flavonoids; Mitogen-Activated Protein Kinase Kinases; Myometrium; Pertussis Toxin; Phosphorylation; Plasmids; Postpartum Period; Pregnancy; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar; Ritodrine; Tocolytic Agents; Tyrosine; Uterine Contraction; Virulence Factors, Bordetella | 1997 |
Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway.
Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Insulin; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 1997 |
Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Survival; DNA; Enzyme Activation; Flavonoids; Islets of Langerhans; Leptin; Mice; Obesity; Phosphorylation; Proteins; Signal Transduction; Trans-Activators; Tyrosine | 1997 |
Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.
Topics: Amino Acid Sequence; Animals; CDC2 Protein Kinase; Cell Cycle; Cell Extracts; Cyclin B; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Flavonoids; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitosis; Molecular Sequence Data; Ovum; Phosphorylation; Protamine Kinase; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-mos; Signal Transduction; Tyrosine; Xenopus | 1998 |
Progesterone stimulates p42 extracellular signal-regulated kinase (p42erk) in human spermatozoa.
Topics: Acrosome; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Ionophores; Male; Mitogen-Activated Protein Kinase 1; Peanut Agglutinin; Phosphorylation; Progesterone; Signal Transduction; Sperm Capacitation; Spermatozoa; Tyrosine | 1998 |
Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Enzyme Activation; Flavonoids; Glycogen; Humans; Insulin Receptor Substrate Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Polyenes; Receptor, Insulin; Ribosomal Protein S6 Kinases; Sirolimus; Tyrosine; Vanadium Compounds; Wortmannin | 1998 |
Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cytotoxicity Tests, Immunologic; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granzymes; HL-60 Cells; Humans; Jurkat Cells; Killer Cells, Natural; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Perforin; Phosphorylation; Pore Forming Cytotoxic Proteins; Serine Endopeptidases; Transfection; Tumor Cells, Cultured; Tyrosine | 1998 |
Extracellular signal-regulated kinases modulate capacitation of human spermatozoa.
Topics: Acrosome; Adult; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Ionophores; Male; Microscopy, Confocal; Microscopy, Immunoelectron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Sperm Capacitation; Spermatozoa; Testis; Tyrosine | 1998 |
Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway.
Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tumor Cells, Cultured; Tyrosine | 1998 |
Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Glycine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Neuroglia; Neuroprotective Agents; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Tyrosine | 1998 |
Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Chromones; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
Modulation of insulin-like growth factor actions in L6A1 myoblasts by insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5: a dual role for IGFBP-5.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Myogenin; Phosphoproteins; Phosphorylation; Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1998 |
Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras.
Topics: Antigen-Antibody Complex; Calcium-Calmodulin-Dependent Protein Kinases; Flavonoids; Humans; Interleukin-1; Models, Immunological; Monocytes; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor Aggregation; Receptors, IgG; Signal Transduction; Tyrosine; U937 Cells | 1998 |
Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tretinoin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated by st
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Growth Hormone; JNK Mitogen-Activated Protein Kinases; Mice; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Prolactin; Rabbits; Receptors, Cytoplasmic and Nuclear; Sheep; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Transcription Factors; Transcriptional Activation; Tyrosine | 1999 |
Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arteries; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Flavonoids; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Receptors, Angiotensin; Tyrosine; Tyrphostins; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 1999 |
Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-3; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; ras Proteins; Receptors, Granulocyte Colony-Stimulating Factor; Tyrosine | 1999 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway.
Topics: 3T3 Cells; Adipocytes; Animals; Endothelin-1; Flavonoids; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sirolimus; Tyrosine | 1999 |
Implication of TNF receptor-I-mediated extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation in growth of AIDS-associated Kaposi's sarcoma cells: a possible role of a novel death domain protein MADD in TNF-alpha-induced ERK1/2 activation in K
Topics: Acquired Immunodeficiency Syndrome; Antibodies, Monoclonal; Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Division; Dactinomycin; Death Domain Receptor Signaling Adaptor Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; Growth Substances; Guanine Nucleotide Exchange Factors; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sarcoma, Kaposi; Threonine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.
Topics: Animals; Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cells, Cultured; Chimera; Cytokine Receptor gp130; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Gene Expression Regulation, Developmental; Helminth Proteins; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Signal Transduction; STAT3 Transcription Factor; Stem Cells; Suppression, Genetic; Trans-Activators; Transfection; Tyrosine | 1999 |
Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells.
Topics: Antioxidants; Arachidonic Acid; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Cholesterol, VLDL; Endothelium, Vascular; Enzyme Inhibitors; Estrenes; Fibrinolysis; Flavonoids; Gallic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase C; Pyrrolidinones; Signal Transduction; Thapsigargin; Tritium; Tumor Cells, Cultured; Tyrosine | 1999 |
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Compartmentation; Cells, Cultured; Endocytosis; ErbB Receptors; Fibroblasts; Flavonoids; Guanosine Diphosphate; Guanosine Triphosphate; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Models, Biological; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1999 |
Stimulation of glycogen synthesis by insulin requires S6 kinase and phosphatidylinositol-3-kinase in HTC-IR cells.
Topics: Animals; Chromones; Enzyme Inhibitors; Flavonoids; Glycogen; Glycogen Synthase; Humans; Immunophilins; Insulin; Insulin Receptor Substrate Proteins; Isoenzymes; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus Binding Proteins; Tumor Cells, Cultured; Tyrosine | 2000 |
Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Differentiation; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Dominant; Humans; Interferon-gamma; Interleukin-6; Mutagenesis, Site-Directed; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Proteins; Proto-Oncogene Proteins p21(ras); Rats; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT1 Transcription Factor; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine | 2000 |
Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells.
Topics: Animals; Benzoquinones; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Insulin Receptor Substrate Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rifabutin; Tyrosine | 2000 |
ERK activation upon hypoxia: involvement in HIF-1 activation.
Topics: Blotting, Western; Cell Hypoxia; Cell Line; Cell Nucleus; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Microcirculation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Transcription Factors; Tyrosine | 2000 |
Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status.
Topics: Animals; Caveolin 1; Caveolins; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Isoforms; Pyrazoles; Pyrimidines; Recombinant Proteins; Signal Transduction; src-Family Kinases; Tyrosine | 2000 |
Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor.
Topics: 3T3 Cells; Actins; Animals; Bombesin; Butadienes; Cell Adhesion Molecules; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tyrosine | 2000 |
Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.
Topics: Animals; Antibodies; Antigens, CD; Cell Division; Cell Line; Cell Survival; Cytokine Receptor gp130; Dexamethasone; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Herpesvirus 8, Human; Humans; Hybridomas; Interleukin-6; Janus Kinase 1; Janus Kinase 2; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neutralization Tests; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Interleukin-6; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT2 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Viral Proteins | 2000 |
Tumor necrosis factor alpha inhibits insulin-induced mitogenic signaling in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2000 |
The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A(2) activity by either FcgammaRIIA or FcgammaRIIIB in human neutrophils. A possible role for Pyk2 but not for the G
Topics: Antigens, CD; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinases; Models, Biological; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Binding; Pyridines; Receptors, IgG; Signal Transduction; Superoxides; Time Factors; Tyrosine; Zymosan | 2000 |
Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42/p44 MAP kinase.
Topics: Animals; Blotting, Northern; Bone and Bones; Cathepsin K; Cathepsins; Cell Survival; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Immunoblotting; Kinetics; Male; Matrix Metalloproteinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrobenzenes; Osteoblasts; Osteoclasts; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rabbits; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tyrosine; Up-Regulation | 2000 |
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Topics: Animals; Blotting, Western; Cell Survival; Chromones; Culture Media, Serum-Free; DNA Fragmentation; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor Receptors; In Situ Nick-End Labeling; Ligands; MAP Kinase Signaling System; Morpholines; Multiple Endocrine Neoplasia Type 2a; PC12 Cells; Phosphatidylinositol 3-Kinases; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 2000 |
Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells.
Topics: Cells, Cultured; Cortactin; CSK Tyrosine-Protein Kinase; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Microfilament Proteins; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Tyrosine | 2000 |
The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent ProB cell line BaF3.
Topics: Animals; B-Lymphocytes; Cell Line; Cell Survival; Enzyme Activation; Flavonoids; Hematopoietic Stem Cells; Hot Temperature; Interleukin-3; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Tyrosine | 2000 |
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, Phytogenic; Carcinoma; Cyanogen Bromide; Cycloheximide; Drug Interactions; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Microtubules; Paclitaxel; Peptide Fragments; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-raf; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine | 2000 |
Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells.
Topics: Animals; Benzoquinones; Butadienes; Cells, Cultured; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrogens; Female; Flavonoids; Gene Expression Regulation; Lactams, Macrocyclic; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pituitary Gland; Prolactin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyrazoles; Pyrimidines; Quinones; Rats; Rats, Inbred F344; Rifabutin; RNA, Messenger; Signal Transduction; src-Family Kinases; Steroids; Transcription, Genetic; Tyrosine | 2000 |
Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.
Topics: Animals; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Nucleus; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrogens; Female; Flavonoids; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoclasts; Ovary; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Proteins; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tyrosine; Up-Regulation | 2001 |
Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
Topics: Anaplastic Lymphoma Kinase; Animals; Base Sequence; Cell Division; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; MAP Kinase Signaling System; Neurons; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor Protein-Tyrosine Kinases; Tyrosine | 2001 |
CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.
Topics: Blotting, Western; Cell Differentiation; Cell Line; Cytoplasm; Enzyme Activation; Flavonoids; Flow Cytometry; Genetic Vectors; Humans; Isoenzymes; Leukocyte Common Antigens; Macrophage-1 Antigen; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocytes; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; U937 Cells | 2001 |
Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Movement; Cells, Cultured; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Kinetin; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Purines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Sesquiterpenes; Time Factors; Tyrosine | 2001 |
Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Flavonoids; Humans; Immunoblotting; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Precipitin Tests; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2000 |
Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol.
Topics: Anisomycin; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Cytoskeleton; Dicumarol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Insulin Receptor Substrate Proteins; Interleukin-3; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pyridines; Receptor, IGF Type 1; Recombinant Proteins; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine | 2001 |
Platelet-derived growth factor inhibits smooth muscle cell adhesion to fibronectin by ERK-dependent and ERK-independent pathways.
Topics: Animals; Aorta; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Flavonoids; Immunoblotting; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Muscle, Smooth; Oligonucleotides, Antisense; Oligopeptides; Paxillin; Peptides; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Precipitin Tests; src-Family Kinases; Swine; Time Factors; Tyrosine | 2001 |
Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Western; Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Receptor, Endothelin A; Receptors, Endothelin; src Homology Domains; src-Family Kinases; Time Factors; Tyrosine; Wortmannin | 2001 |
Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Ghrelin; Humans; Insulin; Insulin Receptor Substrate Proteins; Ligands; MAP Kinase Signaling System; Models, Biological; Peptide Hormones; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2002 |
Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways.
Topics: Animals; Bone and Bones; Collagenases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genes, Dominant; Macrophage Migration-Inhibitory Factors; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Rats; Recombinant Proteins; RNA, Messenger; Signal Transduction; src-Family Kinases; Time Factors; Transcription Factor AP-1; Tyrosine; Up-Regulation | 2002 |
Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
Topics: Animals; Cell Line; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glomerular Mesangium; Glucose; Heparin-binding EGF-like Growth Factor; Hexokinase; Immunohistochemistry; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Ligands; MAP Kinase Signaling System; Mice; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.
Topics: Antibodies, Monoclonal; Apoptosis; Cell Division; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-6; Intracellular Membranes; Kidney Neoplasms; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2002 |
Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.
Topics: Angiotensin II; Animals; Antibodies; Benzoquinones; Calmodulin-Binding Proteins; Digestive System; Digestive System Physiological Phenomena; Enzyme Inhibitors; Female; Flavonoids; Genistein; In Vitro Techniques; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; p120 GTPase Activating Protein; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Tyrosine | 2002 |
Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Amino Acid Motifs; Benzophenanthridines; Bucladesine; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Fetal Blood; Flavonoids; Follicular Fluid; Humans; Isoquinolines; Male; MAP Kinase Kinase Kinase 1; Phenanthridines; Phosphorylation; Progesterone; Protein Kinase C; Protein Serine-Threonine Kinases; Seminal Plasma Proteins; Signal Transduction; Sperm Capacitation; Sulfonamides; Tyrosine; Tyrphostins | 2002 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Colchicine; Cyclodextrins; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Kinetics; Morpholines; Nucleic Acid Synthesis Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; src-Family Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2002 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Differentiation; Cells, Cultured; Drosophila Proteins; Enzyme Inhibitors; Feedback, Physiological; Flavonoids; Mitogen-Activated Protein Kinases; Mutation; Oncogene Proteins; Oncogene Proteins, Fusion; Phosphoprotein Phosphatases; Protein Phosphatase 2; Protein Phosphatase 2C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-ret; ras Proteins; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Thyroid Gland; Tyrosine; Up-Regulation | 2003 |
Delayed arteriolar relaxation after prolonged agonist exposure: functional remodeling involving tyrosine phosphorylation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arterioles; Calcium; Demecolcine; Enzyme Inhibitors; Flavonoids; Genistein; Male; Microtubules; Norepinephrine; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine; Vasoconstrictor Agents; Vasodilation | 2003 |
Regulation of melanosome movement by MAP kinase.
Topics: Animals; Blotting, Western; Cell Movement; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Kinetics; MAP Kinase Signaling System; Melanophores; Melanosomes; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinase 1; Models, Biological; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Time Factors; Tyrosine; Xenopus laevis | 2003 |
Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Janus Kinase 2; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Molecular Mimicry; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Serine; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Nucleus; Chromones; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Luciferases; Melanoma; Membrane Glycoproteins; Milk Proteins; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; TNF-Related Apoptosis-Inducing Ligand; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
TGFbeta1 signaling via alphaVbeta6 integrin.
Topics: Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Division; Cell Line; Cell Line, Tumor; Cytoskeleton; DNA-Binding Proteins; Fibronectins; Flavonoids; HeLa Cells; Humans; Integrins; Microscopy, Confocal; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad4 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Distinct mechanisms mediate the initial and sustained phases of cell migration in epidermal growth factor receptor-overexpressing cells.
Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; ErbB Receptors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myosin-Light-Chain Kinase; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; rho-Associated Kinases; Transforming Growth Factor alpha; Tyrosine | 2003 |
Growth hormone reduces chloride secretion in human colonic epithelial cells via EGF receptor and extracellular regulated kinase.
Topics: Biological Transport; Carbachol; Cell Line; Chlorides; Cholinergic Agonists; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Human Growth Hormone; Humans; Imidazoles; Intestinal Mucosa; Janus Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Tyrosine | 2003 |
1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes.
Topics: Animals; Blotting, Western; Butadienes; Cell-Free System; Chromones; Colforsin; Cycloheximide; Enzyme Inhibitors; Female; Flavonoids; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Pentetic Acid; Phenanthrolines; Phosphorylation; Progesterone; Threonine; Tyrosine; Xenopus laevis; Zinc Sulfate | 2003 |
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts.
Topics: Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cell Line; Cell Nucleus; Contactins; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gingiva; Glucose; Humans; Interleukin-6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neural Cell Adhesion Molecules; Phosphorylation; Receptors, Interleukin-6; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A | 2004 |
Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Blotting, Western; Breast Neoplasms; Cell Division; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; GRB2 Adaptor Protein; Humans; Insulin-Like Growth Factor I; Ligands; MAP Kinase Signaling System; Oligonucleotides; Oligonucleotides, Antisense; Phosphorylation; Precipitin Tests; Prognosis; Protein Binding; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptor, ErbB-2; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Trastuzumab; Tyrosine | 2004 |
Rapid inhibition of leptin signaling by glucocorticoids in vitro and in vivo.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Dexamethasone; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Humans; In Vitro Techniques; Leptin; Male; MAP Kinase Signaling System; Mice; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transfection; Tyrosine | 2004 |
IGF-I increases IGFBP-5 and collagen alpha1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cells, Cultured; Collagen Type I; Crohn Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Intestinal Mucosa; Intestines; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Phosphoproteins; Phosphorylation; Rats; Rats, Inbred Lew; Receptor, IGF Type 1; RNA, Messenger; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Time Factors; Tyrosine | 2004 |
Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation.
Topics: Animals; Binding Sites; Blotting, Western; Calcium; Cell Adhesion; Cell Division; Cell Line; Chelating Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Male; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Models, Biological; Osteoblasts; Phosphorylation; Plasmids; Precipitin Tests; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Wistar; Signal Transduction; Stress, Mechanical; Time Factors; Transfection; Tyrosine | 2004 |
Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells.
Topics: Animals; Caspase 3; Caspase Inhibitors; Cell Line; Enzyme Activation; Epithelial Cells; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Humans; Hydrogen Peroxide; Immunoprecipitation; Mice; Mutation; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Ribosomal Protein S6 Kinases; Two-Hybrid System Techniques; Tyrosine | 2004 |
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; Down-Regulation; Enzyme Inhibitors; Estradiol; Flavonoids; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neurons; Oxidoreductases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Retroviridae; RNA, Small Interfering; Serine; tau Proteins; Temperature; Threonine; Time Factors; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; WW Domain-Containing Oxidoreductase | 2004 |
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Topics: Adaptor Proteins, Signal Transducing; Anaplastic Lymphoma Kinase; Animals; Antibodies, Monoclonal; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Immunoblotting; Immunoprecipitation; Insulin Receptor Substrate Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogens; Neuroblastoma; Neurons; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Thymidine; Time Factors; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cell Movement; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphoproteins; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; ras Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Tyrosine | 2004 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells.
Topics: Base Sequence; Benzophenones; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Integrin alpha5; Ligands; Phosphorylation; PPAR gamma; Promoter Regions, Genetic; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tyrosine | 2005 |
Stretch-induced cell proliferation is mediated by FAK-MAPK pathway.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Fibroblasts; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Rats; Signal Transduction; Stress, Mechanical; Tyrosine | 2005 |
Novel hydroxyl naphthoquinones with potent Cdc25 antagonizing and growth inhibitory properties.
Topics: Antineoplastic Agents; Biotinylation; Blotting, Western; Breast Neoplasms; Carcinoma, Hepatocellular; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell-Free System; DNA; Dual Specificity Phosphatase 1; Flavonoids; Flow Cytometry; Humans; Immediate-Early Proteins; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthoquinones; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Signal Transduction; Time Factors; Transfection; Tyrosine | 2005 |
Direct phosphorylation of proliferative and survival pathway proteins by RET.
Topics: Carcinoma, Medullary; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cattle; Cell Line, Tumor; Cell Proliferation; Densitometry; Flavonoids; Growth Hormone; Guanosine Triphosphate; Immunoblotting; Immunoprecipitation; Insulin; Liver; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Time Factors; Tyrosine | 2006 |
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells.
Topics: Cell Line; Cell Proliferation; Epithelial Cells; Flavonoids; Focal Adhesion Kinase 1; Humans; Lung; Mechanotransduction, Cellular; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; RNA Interference; RNA, Small Interfering; src-Family Kinases; Stress, Mechanical; Time Factors; Transfection; Tyrosine | 2007 |
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Blotting, Northern; Blotting, Western; Butadienes; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Endothelin-1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Leptin; Male; Metalloendopeptidases; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins | 2007 |
Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Topics: Antiviral Agents; Butadienes; Cell Line, Tumor; Cell Transformation, Neoplastic; Colonic Neoplasms; Diterpenes; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gene Expression Regulation, Neoplastic; Hot Temperature; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Nitriles; Oncogene Protein pp60(v-src); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Tyrosine; Ubiquitin; Ubiquitination | 2008 |
Histamine induces human beta-defensin-3 production in human keratinocytes.
Topics: beta-Defensins; Blotting, Western; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Flavonoids; Histamine; Histamine H1 Antagonists; Humans; Infant, Newborn; Janus Kinase 2; Keratinocytes; Male; MAP Kinase Kinase Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyrilamine; Receptors, Histamine H1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tyrosine; Tyrphostins; Up-Regulation | 2009 |
PD98059, a specific MAP kinase inhibitor, attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice.
Topics: Acute Disease; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Adhesion Molecules; Cytokines; Fas Ligand Protein; Flavonoids; I-kappa B Proteins; Inflammation Mediators; Male; Mice; Mitogen-Activated Protein Kinases; Multiple Organ Failure; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peritonitis; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Systemic Inflammatory Response Syndrome; Time Factors; Transcription Factor RelA; Tyrosine; Zymosan | 2010 |
MEK inhibition suppresses the development of lung fibrosis in the bleomycin model.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bleomycin; Body Weight; Butadienes; Fas Ligand Protein; Flavonoids; I-kappa B Proteins; Instillation, Drug; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lung; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Neutrophils; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Nitriles; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pulmonary Edema; Pulmonary Fibrosis; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Myocytes, Cardiac; Oxazoles; Phenylephrine; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2015 |