tyrosine and paclitaxel

tyrosine has been researched along with paclitaxel in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (7.69)	18.7374
1990's	23 (35.38)	18.2507
2000's	24 (36.92)	29.6817
2010's	11 (16.92)	24.3611
2020's	2 (3.08)	2.80

Authors

Authors	Studies
Brandes, ME; Manthey, CL; Perera, PY; Vogel, SN	1
Arregui, C; Barra, HS; Busciglio, J; Caceres, A	1
Bulinski, JC; Chapin, SJ	1
Borisy, GG; Weber, K; Webster, DR; Wehland, J	1
Bulinski, JC; Gundersen, GG; Khawaja, S	1
Bré, MH; Karsenti, E; Kreis, TE	1
de Pennart, H; Houliston, E; Maro, B	1
Flavin, M; Kumar, N	1
Flavin, M; Nath, J; Schiffmann, E	1
Bhalla, K; Bullock, G; Huang, Y; Mahoney, ME; Miyashita, T; Ponnathpur, V; Ray, S; Reed, JC; Tang, C; Willingham, MC	1
Ding, A; Nathan, CF; Sanchez, E	1
Carboni, JM; Singh, C; Tepper, MA	1
Job, D; Manier, M; Mazarguil, H; Paturle-Lafanechère, L; Pirollet, F; Trigault, N	1
Manthey, CL; Qureshi, N; Stütz, PL; Vogel, SN	1
Gundersen, GG; Gurland, G	1
de Médicis, R; Gaudry, M; Gilbert, C; Lussier, A; Malawista, SE; Naccache, PH; Poubelle, PE; Roberge, CJ	1
Duesbery, NS; Masui, Y	1
Becker, E; Bershadsky, A; Chausovsky, A; Geiger, B; Lyubimova, A	1
Horwitz, SB; Wolfson, M; Yang, CP	1
Dougherty, SF; Falk, LA; Pluznik, DH; Rao, P; Sawada, T	1
Chau, MS; Hunter, T; Poon, RY; Yamashita, K	1
Hamm-Alvarez, SF; Vilalta, PM; Zhang, L	1
Chang, YN; Chen, KD; Lai, YK; Lieu, CH; Liu, CC; Yu, TH	1
Gundersen, GG; Mikhailov, A	1
Frackelton, AR; Ravichandran, KS; Stevenson, LE	1
Hortobagyi, GN; Hung, MC; Lau, YK; Xia, W; Zhang, L	1
Shea, TB	1
Matsuura, M; Nakano, M; Saito, S; Tominaga, K	1
Arce, CA; Contín, MA	1
Patrick, DL; Webster, DR	1
Chen, HC; Chen, WP; Lin, CT; Lou, PJ; Wu, JC	1
Horwitz, SB; Yang, CP	1
Ali, S; Deng, H; Dong, K; Giebisch, G; Gu, R; Hebert, SC; Huang, XY; Moral, Z; Sterling, H; Wang, WH; Wei, Y	1
Kucik, DF; Li, J; Zhou, X	1
Gundersen, GG; Lin, SX; Maxfield, FR	1
Dinney, CP; Fan, Z; Hicklin, DJ; Izawa, JI; Karashima, T; Kedar, D; Kim, SJ; Pettaway, C; Shuin, T; Slaton, JW; Sweeney, P	1
Arlinghaus, R; Fang, D; Hung, MC; Jing, T; Lan, KH; Lee, S; Li, P; Liu, J; Nagata, Y; Neal, CL; Tan, M; Yu, D	1
Banerjee, A	1
Adler, G; Algül, H; Beil, M; Schmid, RM; Schneider, G; Tando, Y; Von Weyhern, C; Weber, CK	1
Baas, PW; He, Y; Yu, W	1
Bekele, BN; Bucana, CD; Doan, DD; Fidler, IJ; Greenberg, JS; Holsinger, FC; Jasser, SA; Myers, JN; Schiff, BA; Swan, EA; Younes, MN	1
Arce, CA; Barra, HS; Bisig, CG; Contín, MA; Purro, SA	1
Beinke, C; Cordes, N; Plasswilm, L; van Beuningen, D	1
Annable, T; Fojo, T; Greenberger, LM; Kim, JH; Loganzo, F; Nogales, E; Poruchynsky, MS; Sackett, DL	1
Gildehaus, FJ; Goldbrunner, R; Holtmannspötter, M; Kreth, FW; Pöpperl, G; Tanner, P; Tatsch, K; Tonn, JC	1
Chang, M; Dangas, G; Ellis, SG; Kao, J; Laufer, N; Mehran, R; Russell, ME; Stone, GW; Tannenbaum, MA; Teirstein, PS; Watkins, M	1
Chien, S; Haga, JH; Hu, YL; Li, YS; Miao, H; Wang, Y	1
Höke, A; Jack, C; Lambrinos, GL; Melli, G; Ringkamp, M	1
Clarke, R; Decker, M; Liu, MC; Minshall, RD; Shajahan, AN; Wang, A	1
Ligon, RW; Markwell, SJ; Mishkel, GJ; Moore, AL	1
Devore, D; Dubin, RA; Kohn, J; Piotrowska, K; Sheihet, L	1
Bettinsoli, P; Bonini, SA; Ferrari-Toninelli, G; Memo, M; Uberti, D	1
Lucs, AV; Muller, WJ; Muthuswamy, SK	1
Chaudhury, M; Frank, DA; Nelson, EA; Walker, SR	1
Abbott, JD	1
Alonso, JJ; Alonso-Briales, JH; Ancillo, P; Bethencourt, A; Bosa, F; de Prado, AP; Fernández-Avilés, F; Gimeno, F; López-Messa, J; San Román, JA; Sánchez, PL; Sanchis, J; Santos, I; Sanz, JJ	1
Ahmed, AA; Bast, RC; Claret, FX; He, G; Hung, MC; Le, XF; Mao, W; Siddik, ZH; Xia, W	1
Bushman, J; Garbuzenko, OB; Gounder, MK; Kohn, J; Minko, T; Sheihet, L	1
Kilfoyle, BE; Kohn, J; Laohoo, M; Michniak-Kohn, BB; Sheihet, L; Zhang, Z	1
Lipka, E; Müller, S	1
Andreadaki, A; Diekmann, H; Fischer, D; Gobrecht, P; Heskamp, A; Leibinger, M	1
Dai, Z; Diao, Y; Kang, H; Lin, S; Ma, X; Min, W; Wang, X; Zhao, Y	1
Clark, JL; Janusis, J; Mercado-Matos, J; Piper, AJ; Shaw, LM	1
Fujiwara, H; Koyanagi, T; Mizukami, H; Saga, Y; Takahashi, S; Takahashi, Y; Takei, Y; Tamura, K; Taneichi, A; Urabe, M; Yoshiba, T	1
Higaki, T; Hotta, T; Ohi, R; Verhey, KJ; Yue, Y	1

Trials

3 trial(s) available for tyrosine and paclitaxel

Article	Year
O-(2-[18F]fluoroethyl)-L-tyrosine PET for monitoring the effects of convection-enhanced delivery of paclitaxel in patients with recurrent glioblastoma. European journal of nuclear medicine and molecular imaging, 2005, Volume: 32, Issue:9 Topics: Antineoplastic Agents; Brain Neoplasms; Convection; Drug Delivery Systems; Female; Glioblastoma; Humans; Infusions, Intralesional; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome; Tyrosine	2005
Impact of platelet glycoprotein IIb/IIIa Inhibition on the paclitaxel-eluting stent in patients with stable or unstable angina pectoris or provocable myocardial ischemia (a TAXUS IV substudy). The American journal of cardiology, 2005, Aug-15, Volume: 96, Issue:4 Topics: Abciximab; Angina, Unstable; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Coated Materials, Biocompatible; Coronary Angiography; Coronary Restenosis; Creatine Kinase; Creatine Kinase, MB Form; Double-Blind Method; Drug Interactions; Eptifibatide; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Isoenzymes; Male; Middle Aged; Myocardial Ischemia; Myocardial Revascularization; Paclitaxel; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Tirofiban; Treatment Outcome; Tyrosine	2005
Role of the paclitaxel-eluting stent and tirofiban in patients with ST-elevation myocardial infarction undergoing postfibrinolysis angioplasty: the GRACIA-3 randomized clinical trial. Circulation. Cardiovascular interventions, 2010, Volume: 3, Issue:4 Topics: Angioplasty; Drug-Eluting Stents; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Tirofiban; Treatment Outcome; Tyrosine	2010

Other Studies

62 other study(ies) available for tyrosine and paclitaxel

Article	Year
Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages. Journal of immunology (Baltimore, Md. : 1950), 1992, Oct-01, Volume: 149, Issue:7 Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Gene Expression; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Paclitaxel; Phosphorylation; Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine	1992
Tyrosinated and detyrosinated microtubules in axonal processes of cerebellar macroneurons grown in culture. Journal of neuroscience research, 1991, Volume: 28, Issue:2 Topics: Alkaloids; Animals; Axons; Cells, Cultured; Cerebellum; Immunohistochemistry; Microtubules; Neurons; Nocodazole; Paclitaxel; Tubulin; Tyrosine	1991
Preparation and functional assay of pure populations of tyrosinated and detyrosinated tubulin. Methods in enzymology, 1991, Volume: 196 Topics: Alkaloids; Animals; Brain; Cattle; Cell Fractionation; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Indicators and Reagents; Macromolecular Substances; Microtubule-Associated Proteins; Microtubules; Molecular Weight; Neurons; Paclitaxel; Tubulin; Tyrosine; Ultracentrifugation	1991
Detyrosination of alpha tubulin does not stabilize microtubules in vivo. The Journal of cell biology, 1990, Volume: 111, Issue:1 Topics: Alkaloids; Animals; Antibodies; Cells, Cultured; Culture Media; Kinetics; Mice; Microtubules; Paclitaxel; Peptide Synthases; Tubulin; Tyrosine	1990
Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules. The Journal of cell biology, 1987, Volume: 105, Issue:1 Topics: Alkaloids; Animals; Azides; Benzimidazoles; Cell Line; Chlorocebus aethiops; Epithelial Cells; Fluorescent Antibody Technique; Kidney; Microtubules; Models, Biological; Nocodazole; Paclitaxel; Protein Processing, Post-Translational; Sodium Azide; Tubulin; Tyrosine; Vinblastine	1987
Control of microtubule nucleation and stability in Madin-Darby canine kidney cells: the occurrence of noncentrosomal, stable detyrosinated microtubules. The Journal of cell biology, 1987, Volume: 105, Issue:3 Topics: Alkaloids; Animals; Benzimidazoles; Carboxypeptidases; Carboxypeptidases A; Cell Line; Cell Nucleus; Centrioles; Dogs; Kidney; Kinetics; Microscopy, Electron; Microtubules; Nocodazole; Paclitaxel; Tubulin; Tyrosine	1987
Post-translational modifications of tubulin and the dynamics of microtubules in mouse oocytes and zygotes. Biology of the cell, 1988, Volume: 64, Issue:3 Topics: Acetylation; Alkaloids; Animals; Benzimidazoles; Fluorescent Antibody Technique; Meiosis; Mice; Microtubules; Nocodazole; Oocytes; Paclitaxel; Protein Processing, Post-Translational; Tubulin; Tyrosine; Zygote	1988
Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin. The Journal of biological chemistry, 1981, Jul-25, Volume: 256, Issue:14 Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Calcium Chloride; Carbon Radioisotopes; Carboxypeptidases; Cattle; Colchicine; Kinetics; Paclitaxel; Substrate Specificity; Terpenes; Tubulin; Tyrosine; Vinblastine	1981
Stimulation of tubulin tyrosinolation in rabbit leukocytes evoked by the chemoattractant formyl-methionyl-leucyl-phenylalanine. The Journal of cell biology, 1981, Volume: 91, Issue:1 Topics: Alkaloids; Animals; Chemotaxis, Leukocyte; Colchicine; Leukocytes; Methionine; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Paclitaxel; Peptide Synthases; Protein Binding; Rabbits; Tubulin; Tyrosine	1981
High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells. Leukemia, 1994, Volume: 8, Issue:11 Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; DNA Damage; DNA, Neoplasm; In Vitro Techniques; Microtubules; Paclitaxel; Phosphoproteins; Phosphotyrosine; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tubulin; Tumor Cells, Cultured; Tyrosine	1994
Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase. Journal of immunology (Baltimore, Md. : 1950), 1993, Nov-15, Volume: 151, Issue:10 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Female; Insulin; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C3H; Paclitaxel; Phosphorylation; Tyrosine	1993
Taxol and lipopolysaccharide activation of a murine macrophage cell line and induction of similar tyrosine phosphoproteins. Journal of the National Cancer Institute. Monographs, 1993, Issue:15 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytokines; Lipopolysaccharides; Macrophage Activation; Mice; Microtubules; Paclitaxel; Phosphoproteins; Phosphorylation; Signal Transduction; Tyrosine	1993
Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies. Journal of cell science, 1994, Volume: 107 ( Pt 6) Topics: 3T3 Cells; Adrenal Cortex; Amino Acid Sequence; Animals; Cattle; Cells, Cultured; Centrosome; Cerebellum; Cilia; Flagella; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; HeLa Cells; Humans; Male; Mice; Microtubule-Associated Proteins; Microtubules; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Paclitaxel; Protein Processing, Post-Translational; Purkinje Cells; Rats; Sea Urchins; Tubulin; Tyrosine	1994
Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages. The Journal of experimental medicine, 1993, Aug-01, Volume: 178, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; Docetaxel; Gene Expression; Lipid A; Macrophages; Mice; Mice, Inbred C3H; Microtubules; Paclitaxel; Phosphorylation; Signal Transduction; Taxoids; Tumor Necrosis Factor-alpha; Tyrosine	1993
Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts. The Journal of cell biology, 1995, Volume: 131, Issue:5 Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Fibroblasts; Intermediate Filaments; Mice; Microtubules; Nocodazole; Paclitaxel; Serum Albumin, Bovine; Tubulin; Tyrosine; Vimentin	1995
Paradoxical effects of colchicine on the activation of human neutrophilis by chemotactic factors and inflammatory microcrystal. Journal of leukocyte biology, 1996, Volume: 59, Issue:6 Topics: Adult; Calcium Pyrophosphate; Colchicine; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophil Activation; Neutrophils; Paclitaxel; Phosphorylation; Tyrosine; Uric Acid	1996
The role of microtubules and inositol triphosphate induced Ca2+ release in the tyrosine phosphorylation of mitogen-activated protein kinase in extracts of Xenopus laevis oocytes. Zygote (Cambridge, England), 1996, Volume: 4, Issue:1 Topics: Animals; Biopolymers; Calcium; Enzyme Activation; Female; Inositol Phosphates; Microsomes; Microtubules; Nocodazole; Oocytes; Paclitaxel; Phosphorylation; Protein Kinases; Tyrosine; Xenopus laevis	1996
Involvement of microtubules in the control of adhesion-dependent signal transduction. Current biology : CB, 1996, Oct-01, Volume: 6, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actin Cytoskeleton; Alkaloids; Animals; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; DNA; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Indoles; Integrins; Isoflavones; Mice; Microtubules; Myosin-Light-Chain Kinase; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinblastine	1996
Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells. International journal of cancer, 1997, Jan-17, Volume: 70, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antineoplastic Agents, Phytogenic; Calcium-Calmodulin-Dependent Protein Kinases; GRB2 Adaptor Protein; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Paclitaxel; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine	1997
Colchicine down-regulates lipopolysaccharide-induced granulocyte-macrophage colony-stimulating factor production in murine macrophages. Journal of immunology (Baltimore, Md. : 1950), 1997, Oct-01, Volume: 159, Issue:7 Topics: Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Colchicine; Down-Regulation; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Lipopolysaccharides; Macrophages; Mice; Microtubules; NF-kappa B; Paclitaxel; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger; Time Factors; Transcription, Genetic; Tubulin; Tyrosine	1997
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer research, 1997, Nov-15, Volume: 57, Issue:22 Topics: 3T3 Cells; Animals; Antineoplastic Agents; Caffeine; CDC2 Protein Kinase; Cyclin A; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Doxorubicin; Electrophoresis, Polyacrylamide Gel; G1 Phase; G2 Phase; Humans; Mice; Mitosis; Nocodazole; Paclitaxel; Phosphorylation; Protein Kinases; Threonine; Tumor Cells, Cultured; Tyrosine	1997
A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments. Journal of cell science, 1998, Volume: 111 ( Pt 13) Topics: Acetylation; Animals; Carbazoles; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Indole Alkaloids; Intermediate Filaments; Kidney; Microtubules; Okadaic Acid; Paclitaxel; Phosphoprotein Phosphatases; Phosphorylation; Tyrosine; Vimentin	1998
Role of mitogen-activated protein kinase in taxol-induced apoptosis in human leukemic U937 cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1998, Volume: 9, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Separation; Enzyme Inhibitors; Eukaryotic Cells; Flow Cytometry; G1 Phase; G2 Phase; Humans; Lymphoma, Large B-Cell, Diffuse; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitosis; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; S Phase; Tyrosine; U937 Cells	1998
Relationship between microtubule dynamics and lamellipodium formation revealed by direct imaging of microtubules in cells treated with nocodazole or taxol. Cell motility and the cytoskeleton, 1998, Volume: 41, Issue:4 Topics: Animals; Cell Adhesion; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Image Processing, Computer-Assisted; Microtubules; Nocodazole; Paclitaxel; Tyrosine	1998
Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1999, Volume: 10, Issue:1 Topics: Breast; Breast Neoplasms; Cell Cycle; Epithelial Cells; Female; G1 Phase; G2 Phase; Humans; Mitosis; Nocodazole; Paclitaxel; Phosphorylation; Receptor, ErbB-2; Resting Phase, Cell Cycle; src Homology Domains; Stem Cells; Tumor Cells, Cultured; Tyrosine	1999
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:2 Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Division; Disease Models, Animal; Drug Synergism; Emodin; Enzyme Inhibitors; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine	1999
Selective stabilization of microtubules within the proximal region of developing axonal neurites. Brain research bulletin, 1999, Volume: 48, Issue:3 Topics: Acetylation; Animals; Antineoplastic Agents, Phytogenic; Axons; Cell Differentiation; Colchicine; Microscopy, Immunoelectron; Microtubules; Neurites; Neuroblastoma; Neurons; Paclitaxel; Tubulin; Tumor Cells, Cultured; Tyrosine	1999
Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappaB cascades, but not lipopolysaccharide-incorporatio Biochimica et biophysica acta, 1999, Jun-08, Volume: 1450, Issue:2 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Drug Tolerance; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; NF-kappa B; Paclitaxel; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine	1999
Tubulin carboxypeptidase/microtubules association can be detected in the distal region of neural processes. Neurochemical research, 2000, Volume: 25, Issue:1 Topics: Animals; Brain; Carboxypeptidases; Cells, Cultured; Chick Embryo; Fluorescent Antibody Technique; Glutamine; Microtubules; Paclitaxel; Time Factors; Tubulin; Tyrosine	2000
Beating rate of isolated neonatal cardiomyocytes is regulated by the stable microtubule subset. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:5 Topics: Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Heart Rate; Microtubules; Myocardial Contraction; Myocardium; Nocodazole; Paclitaxel; Rats; Rats, Sprague-Dawley; Tubulin; Tubulin Modulators; Tyrosine	2000
Taxol reduces cytosolic E-cadherin and beta-catenin levels in nasopharyngeal carcinoma cell line TW-039: cross-talk between the microtubule- and actin-based cytoskeletons. Journal of cellular biochemistry, 2000, Sep-14, Volume: 79, Issue:4 Topics: Actins; Adenomatous Polyposis Coli Protein; Antineoplastic Agents, Phytogenic; beta Catenin; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Size; Cytoskeletal Proteins; Cytoskeleton; Cytosol; Glycogen Synthase Kinase 3; Humans; Microtubules; Nasopharyngeal Neoplasms; Neoplasm Proteins; Paclitaxel; Phosphorylation; Trans-Activators; Tumor Cells, Cultured; Tyrosine	2000
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform. Cancer research, 2000, Sep-15, Volume: 60, Issue:18 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, Phytogenic; Carcinoma; Cyanogen Bromide; Cycloheximide; Drug Interactions; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Microtubules; Paclitaxel; Peptide Fragments; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-raf; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine	2000
Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase. The Journal of biological chemistry, 2001, Mar-09, Volume: 276, Issue:10 Topics: Alanine; Animals; Benzoquinones; Blotting, Western; Colchicine; Concanavalin A; Enzyme Inhibitors; Lactams, Macrocyclic; Microscopy, Fluorescence; Microtubules; Models, Biological; Mutation; Oocytes; Paclitaxel; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Complementary; Sucrose; Time Factors; Tyrosine; Xenopus	2001
The microtubule cytoskeleton participates in control of beta2 integrin avidity. The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48 Topics: Animals; Antineoplastic Agents; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Line; Cell Line, Transformed; Colchicine; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Gout Suppressants; Humans; Integrins; Macrophages; Mice; Microscopy, Video; Microtubules; Models, Statistical; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine	2001
Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin. Molecular biology of the cell, 2002, Volume: 13, Issue:1 Topics: Animals; Antibodies; Cell Compartmentation; Cell Line; Cell Membrane; Centrioles; CHO Cells; Cricetinae; Endocytosis; Fluorescent Antibody Technique; Glutamic Acid; HeLa Cells; Humans; Kinesins; Microscopy, Fluorescence; Microtubules; Nocodazole; Paclitaxel; Protein Transport; Transferrin; Transport Vesicles; Tyrosine	2002
Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:5 Topics: Androgens; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Blood Vessels; Cell Cycle Proteins; Cell Division; Cetuximab; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Paclitaxel; Phosphorylation; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Up-Regulation; Xenograft Model Antitumor Assays	2002
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Molecular cell, 2002, Volume: 9, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast; Breast Neoplasms; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cells, Cultured; Cyclin B; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; Drug Resistance, Neoplasm; Female; Humans; In Situ Nick-End Labeling; Mitosis; Paclitaxel; Phosphorylation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine	2002
Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. Biochemical and biophysical research communications, 2002, Apr-26, Volume: 293, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Paclitaxel; Protein Isoforms; Tubulin; Tumor Cells, Cultured; Tyrosine	2002
Different modes of NF-kappaB/Rel activation in pancreatic lobules. American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:2 Topics: Animals; Ceruletide; Dose-Response Relationship, Drug; Enzyme Activation; Hydrogen Peroxide; I-kappa B Kinase; I-kappa B Proteins; Kinetics; Male; Microtubules; NF-kappa B; NF-kappa B p50 Subunit; Nocodazole; Oxidants; Paclitaxel; Phosphorylation; Polymers; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine	2002
Microtubule reconfiguration during axonal retraction induced by nitric oxide. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jul-15, Volume: 22, Issue:14 Topics: Animals; Antineoplastic Agents; Axons; Cells, Cultured; Chick Embryo; Cytoskeleton; Ganglia, Spinal; Hydrazines; Microscopy, Fluorescence; Microtubules; Neurons; Nitric Oxide; Nitric Oxide Donors; Nocodazole; Paclitaxel; Tubulin; Tyrosine	2002
Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Head and Neck Neoplasms; Humans; In Situ Nick-End Labeling; Ligands; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Mouth Neoplasms; Neoplasms; Paclitaxel; Phosphorylation; Propidium; Pyrimidines; Pyrroles; Tongue; Tongue Neoplasms; Tyrosine	2003
Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules. European journal of biochemistry, 2003, Volume: 270, Issue:24 Topics: Animals; Carboxypeptidases; Catalase; COS Cells; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Immunoblotting; Microscopy, Fluorescence; Microtubules; Okadaic Acid; Paclitaxel; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Phosphatase 1; Temperature; Tyrosine	2003
Irradiation and various cytotoxic drugs enhance tyrosine phosphorylation and beta(1)-integrin clustering in human A549 lung cancer cells in a substratum-dependent manner in vitro. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2004, Volume: 180, Issue:3 Topics: Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell Survival; Cisplatin; Colony-Forming Units Assay; Extracellular Matrix Proteins; Fibronectins; Fluorescent Antibody Technique; Humans; Integrin beta Chains; Lung Neoplasms; Microscopy, Confocal; Mitomycin; Paclitaxel; Phosphorylation; Polystyrenes; Radiation Dosage; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Tyrosine	2004
Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability. Biochemistry, 2004, Nov-09, Volume: 43, Issue:44 Topics: Acetylation; Cell Line, Tumor; Cold Temperature; Dimerization; Drug Resistance, Neoplasm; Female; Growth Inhibitors; Humans; Microtubules; Mutation; Oligopeptides; Ovarian Neoplasms; Paclitaxel; Protein Structure, Secondary; Protein Structure, Tertiary; Tubulin; Tyrosine	2004
Roles of microfilaments and microtubules in paxillin dynamics. Biochemical and biophysical research communications, 2006, Oct-06, Volume: 348, Issue:4 Topics: Actin Cytoskeleton; Animals; Cattle; Cell Movement; Cells, Cultured; Colchicine; Cytochalasin D; Endothelium, Vascular; Focal Adhesions; Microtubules; Paclitaxel; Paxillin; Phosphorylation; Tubulin Modulators; Tyrosine	2006
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration. Neurobiology of disease, 2006, Volume: 24, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Erythropoietin; Female; Ganglia, Spinal; Glycerol; Humans; Injections, Intraperitoneal; Mice; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Recombinant Proteins; Tubulin; Tyrosine	2006
Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. The Journal of biological chemistry, 2007, Feb-23, Volume: 282, Issue:8 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Membrane Permeability; Cell Transformation, Neoplastic; Humans; Microtubules; Mitochondria; Paclitaxel; Phosphorylation; Protein Processing, Post-Translational; Tubulin Modulators; Tyrosine	2007
Bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in drug-eluting stent implantations in the absence of acute myocardial infarction: clinical and economic results. The Journal of invasive cardiology, 2007, Volume: 19, Issue:2 Topics: Abciximab; Aged; Antibodies, Monoclonal; Anticoagulants; Coronary Artery Disease; Costs and Cost Analysis; Drug Delivery Systems; Drug Therapy, Combination; Eptifibatide; Female; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Length of Stay; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Peptide Fragments; Peptides; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Retrospective Studies; Sirolimus; Stents; Tirofiban; Treatment Outcome; Tyrosine	2007
Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery. Biomacromolecules, 2007, Volume: 8, Issue:3 Topics: Chromatography, High Pressure Liquid; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Macromolecular Substances; Models, Chemical; Molecular Weight; Nanostructures; Nanotubes; Paclitaxel; Polyethylene Glycols; Polymers; Structure-Activity Relationship; Tyrosine	2007
Microtubule stabilizing effect of notch activation in primary cortical neurons. Neuroscience, 2008, Jun-26, Volume: 154, Issue:3 Topics: Adenosine Triphosphatases; Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents, Phytogenic; Calcium-Binding Proteins; Cerebral Cortex; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Ligands; Membrane Proteins; Mice; Microscopy, Confocal; Microtubules; Neurons; Paclitaxel; Polyglutamic Acid; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA; Serrate-Jagged Proteins; Signal Transduction; Spastin; Tubulin; Tyrosine	2008
Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene, 2010, Jan-14, Volume: 29, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Blotting, Western; Cell Culture Techniques; Cell Line; Cell Polarity; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Drug Resistance; Fibroblasts; Flow Cytometry; Humans; Mutation; Paclitaxel; Phosphorylation; Receptor, ErbB-2; Shc Signaling Adaptor Proteins; Tyrosine	2010
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Molecular pharmacology, 2010, Volume: 78, Issue:5 Topics: Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Female; Gene Expression Regulation; Genes, Reporter; Humans; Paclitaxel; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Tubulin; Tubulin Modulators; Tyrosine; Vinblastine; Vinorelbine	2010
Pharmacoinvasive strategy for ST-segment elevation myocardial infarction: wading through the treatment options. Circulation. Cardiovascular interventions, 2010, Volume: 3, Issue:4 Topics: Angioplasty; Anticoagulants; Drug-Eluting Stents; Humans; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Tirofiban; Tyrosine; Ultrasonography	2010
The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. Journal of the National Cancer Institute, 2011, Sep-21, Volume: 103, Issue:18 Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Confounding Factors, Epidemiologic; Cyclin-Dependent Kinase Inhibitor p27; Dasatinib; Drug Synergism; Female; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Genes, bcl-1; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Research Design; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Serine; src-Family Kinases; Thiazoles; Threonine; Tyrosine; Xenograft Model Antitumor Assays	2011
Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: in vivo evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Feb-14, Volume: 45, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Carriers; Female; Glycerol; Humans; Maximum Tolerated Dose; Mice; Mice, Nude; Nanospheres; Neoplasms; Paclitaxel; Pharmaceutical Vehicles; Tyrosine; Xenograft Model Antitumor Assays	2012
Development of paclitaxel-TyroSpheres for topical skin treatment. Journal of controlled release : official journal of the Controlled Release Society, 2012, Oct-10, Volume: 163, Issue:1 Topics: Administration, Cutaneous; Antineoplastic Agents, Phytogenic; Cell Line; Drug Carriers; Humans; Nanospheres; Paclitaxel; Skin; Skin Absorption; Tyrosine	2012
Nitrosative stress triggers microtubule reorganization in Arabidopsis thaliana. Journal of experimental botany, 2014, Volume: 65, Issue:15 Topics: Arabidopsis; Dinitrobenzenes; Microtubules; Mitosis; Nitric Oxide; Paclitaxel; Plant Roots; Stress, Physiological; Sulfanilamides; Tyrosine	2014
Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Apr-06, Volume: 36, Issue:14 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Axons; Dose-Response Relationship, Drug; Gene Knock-In Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL; Microtubules; Nerve Regeneration; Nocodazole; Paclitaxel; Peripheral Nerves; Phosphorylation; Sciatic Nerve; Sesquiterpenes; Tyrosine	2016
Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src. Cancer letters, 2016, 08-28, Volume: 379, Issue:1 Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 8; Cisplatin; Dasatinib; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Necrosis; Paclitaxel; Phosphorylation; Pregnancy; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; Signal Transduction; Time Factors; Transfection; Treatment Outcome; Tyrosine; Xenograft Model Antitumor Assays	2016
Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells. The Journal of biological chemistry, 2017, 05-12, Volume: 292, Issue:19 Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cytoskeleton; Female; Humans; Insulin Receptor Substrate Proteins; Microscopy, Fluorescence; Microtubules; Paclitaxel; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Somatomedin; Signal Transduction; Tubulin; Tyrosine	2017
Knockout of vasohibin-2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer. Cancer medicine, 2021, Volume: 10, Issue:8 Topics: Angiogenic Proteins; Antineoplastic Agents, Phytogenic; Carboxypeptidases; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; CRISPR-Cas Systems; Cyclin B1; Female; Gene Knockdown Techniques; Humans; Ovarian Neoplasms; Paclitaxel; Tubulin; Tyrosine	2021
Microtubule detyrosination by VASH1/SVBP is regulated by the conformational state of tubulin in the lattice. Current biology : CB, 2023, 10-09, Volume: 33, Issue:19 Topics: Guanosine Triphosphate; Microtubules; Paclitaxel; Tubulin; Tyrosine	2023