tyrosine has been researched along with okadaic acid in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 44 (62.86) | 18.2507 |
| 2000's | 22 (31.43) | 29.6817 |
| 2010's | 3 (4.29) | 24.3611 |
| 2020's | 1 (1.43) | 2.80 |
| Authors | Studies |
|---|---|
| Grinstein, S; Leto, TL; Lu, DJ; Takai, A | 1 |
| Brautigan, DL; Chen, J; Martin, BL | 1 |
| Leader, NK; Roberts, MH; Towles, JA | 1 |
| Chiang, TM | 1 |
| Cavadore, JC; Devault, A; Dorée, M; Fesquet, D; Garrigues, AM; Labbé, JC; Lorca, T; Philippe, M; Picard, A | 1 |
| Corvera, S; Jaspers, S; Pasceri, M | 1 |
| Goris, J; Haccard, O; Jessus, C; Merlevede, W; Ozon, R; Rime, H; Van Lint, J | 1 |
| Hoppe, J; Hoppe, V; Karenberg, TA; Simm, A | 1 |
| Yang, SD; Yu, JS | 1 |
| Bagrodia, S; Chackalaparampil, I; Shalloway, D | 1 |
| Rieber, M; Rieber, MS | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Huang, CK; Liang, L | 1 |
| Jessus, C; Ozon, R; Rime, H | 1 |
| Bordin, L; Clari, G; Dalla Vecchia, F; Moret, V; Moro, I | 1 |
| Jones, PM; Persaud, SJ; Wheeler-Jones, CP | 1 |
| Colasanto, JM; Gomez-Cambronero, J; Huang, CK; Sha'afi, RI | 1 |
| Bishop, WP; Born, E; Field, FJ; Mathur, SN | 1 |
| Rapp, UR; Reed, JC; Tonks, NK; Turner, BC | 1 |
| Ohmichi, M; Pang, L; Ribon, V; Saltiel, AR | 1 |
| Leslie, CC; Qiu, ZH | 1 |
| Gazit, A; Hoppe, J; Hoppe, V; Simm, A | 1 |
| Aussel, C; Bernard, A; Breittmayer, JP; Deckert, M | 1 |
| Grémeaux, T; Le Marchand-Brustel, Y; Tanti, JF; van Obberghen, E | 1 |
| Cormont, M; Grémeaux, T; Le Marchand-Brustel, Y; Tanti, JF; Van Obberghen, E | 1 |
| Goris, J; Haccard, O; Jessus, C; Merlevede, W; Ozon, R; Rime, H | 1 |
| Amaral, K; Casillas, AM; Chegini-Farahani, S; Nel, AE | 1 |
| Lee, EY; Long, F; Zhang, L; Zhang, Z | 1 |
| Rondinone, CM; Smith, U | 1 |
| Artçanuthurry, V; Grelac, F; Levy-Tolédano, S; Maclouf, J; Martin-Cramer, E | 1 |
| Bajpai, A; Brahmi, Z | 1 |
| Londos, C; Rondinone, CM; Smith, UP; Zarnowski, MJ | 1 |
| Artçanuthurry, V; Grelac, F; Lévy-Tolédano, S; Maclouf, J; Mauco, G; Pidard, D | 1 |
| Kasahara, T; Kuno, K; Matsushima, K; Mukaida, N; Sonoda, Y; Yamaguchi, Y | 1 |
| Aggarwal, BB; Darnay, BG | 1 |
| Patel, R; Whitaker, M; Wright, EM | 1 |
| Choudhry, MA; Mayer, AM; Sayeed, MM; Spitzer, JA | 1 |
| Elhanany, E; Hemi, R; Kanety, H; Karasik, A; LeRoith, D; Paz, K; Zick, Y | 1 |
| Hamm-Alvarez, SF; Vilalta, PM; Zhang, L | 1 |
| Lazo, JS; Rice, RL; Settineri, CE; Vogt, A; Wipf, P; Yokokawa, F; Yokokawa, S | 1 |
| Kwiatkowska, K; Sobota, A | 1 |
| Barchi, M; Bianchini, A; Conti, M; Geremia, R; Rossi, P; Sette, C | 1 |
| Ferrell, JE; Sohaskey, ML | 1 |
| Hirai, H; Ishihara, H; Ishiki, M; Kobayashi, M; Sasaoka, T; Sawa, T; Wada, T | 1 |
| Strayer, DS; White, MK | 1 |
| Brooks, DP; Hall, CS; Nambi, P; Parameswaran, N; Spielman, WS | 1 |
| Liao, C; Liu, D; Wolgemuth, DJ | 1 |
| Hong, HN; Kim, D; Kim, JU; Koh, WK; Lee, JH | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Browning, MD; Grosshans, DR | 1 |
| Miller, WT; Reich, NC; Yokoyama, N | 1 |
| Akiba, S; Hayama, M; Kitatani, K; Sato, T | 1 |
| Edberg, JC; Gibson, AW; Indik, ZK; Kimberly, RP; Qin, H; Redecha, PB; Schreiber, AD; Yee, AM | 1 |
| Chai, SP; Fong, JC | 1 |
| Akkerman, JW; Ferreira, IA; Gorter, G; Relou, IA; van Rijn, HJ | 1 |
| Guthridge, MA; Lindeman, GJ; Lopez, AF; Olayioye, MA; Stomski, FC; Visvader, JE | 1 |
| Abe, T; Degawa-Yamauchi, M; Eguchi, K; Fujita, N; Kita, A; Kuwahara, H; Ohshima, K; Sakamaki, H; Takahashi, R; Uotani, S; Yamaguchi, Y; Yamasaki, H | 1 |
| Arce, CA; Barra, HS; Bisig, CG; Contín, MA; Purro, SA | 1 |
| Botos, E; Kiss, AL; Müllner, N; Turi, A | 1 |
| Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P | 1 |
| de Lamirande, E; Gagnon, C; O'Flaherty, C | 1 |
| Armstrong, DL; Darden, T; Erxleben, C; Gentile, S; Martin, N; Romeo, C; Rossie, S; Russo, A | 1 |
| Arora, A; Fibuch, EE; Kingston, S; Mao, L; Wang, JQ; Yang, L | 1 |
| Alvarez, SE; Ayub, MJ; Ciuffo, GM; Villarreal, RS | 1 |
| Juno, C; Montgomery, L; Mudrak, I; Nunbhakdi-Craig, V; Ogris, E; Pallas, DC; Schuechner, S; Sontag, E; Sontag, JM | 1 |
| Choi, JE; Choi, JM; Kim, DH; Yoon, SY | 1 |
| Arcelay, E; Krapf, D; Pilder, SH; Salicioni, AM; Sanjay, A; Visconti, PE; Wertheimer, EV | 1 |
| Dudiki, T; Ferrara, JK; Kadunganattil, S; Kline, DW; Vijayaraghavan, S | 1 |
| Gao, WB; Kuai, XX; Li, L; Wang, Q; Yang, CC; Yu, JC; Zhang, L | 1 |
| Jiang, D; Kong, L; Ma, C; Sun, X; Wan, H; Wang, P; Wang, T; Wang, X; Zhou, S | 1 |
70 other study(ies) available for tyrosine and okadaic acid
| Article | Year |
|---|---|
Modulation of neutrophil activation by okadaic acid, a protein phosphatase inhibitor.
Topics: Cell Membrane Permeability; Ethers, Cyclic; Humans; Neutrophils; Okadaic Acid; Oxygen Consumption; Phosphoprotein Phosphatases; Proteins; Tyrosine | 1992 |
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation.
Topics: Animals; ErbB Receptors; Ethers, Cyclic; Gene Expression Regulation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Okadaic Acid; Oncogene Protein pp60(v-src); Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein-Tyrosine Kinases; Rabbits; Receptor, Insulin; Thionucleotides; Tyrosine | 1992 |
Tyrosine kinase regulation of a molluscan circadian clock.
Topics: Animals; Arsenicals; Biological Clocks; Circadian Rhythm; Ethers, Cyclic; Eye; Genistein; Isoflavones; Okadaic Acid; Phosphates; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Snails; Tyrosine | 1992 |
Okadaic acid and vanadate inhibit collagen-induced platelet aggregation; the functional relation of phosphatases on platelet aggregation.
Topics: Adenosine Triphosphate; Blood Platelets; Collagen; Depression, Chemical; Ethers, Cyclic; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphotyrosine; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Phosphatase 1; Serotonin; Tyrosine; Vanadates | 1992 |
Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.
Topics: Amino Acid Sequence; Animals; CDC2 Protein Kinase; Cyclins; Enzyme Activation; Ethers, Cyclic; Humans; Interphase; Maturation-Promoting Factor; Models, Biological; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine; Vanadates; Xenopus | 1992 |
Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Cell Membrane; Deoxyglucose; Dose-Response Relationship, Drug; Ethers, Cyclic; In Vitro Techniques; Insulin; Insulin Antagonists; Male; Methylglucosides; Monosaccharide Transport Proteins; Okadaic Acid; Phosphotyrosine; Rats; Tyrosine | 1991 |
Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte. Antagonistic action of okadaic acid and 6-DMAP.
Topics: Adenine; Animals; CDC2 Protein Kinase; Ethers, Cyclic; Female; Immunoblotting; Ionophores; Maturation-Promoting Factor; Meiosis; Okadaic Acid; Oocytes; Phosphorylation; Proteins; Tyrosine; Xenopus laevis | 1991 |
Okadaic acid blocks PDGF-induced proliferation of AKR-2B fibroblasts at the transition from G1- to S-phase.
Topics: Animals; Becaplermin; Cell Cycle; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Ethers, Cyclic; Fibroblasts; G1 Phase; Inositol Phosphates; Kinetics; Mice; Mice, Inbred AKR; Okadaic Acid; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-sis; Recombinant Proteins; S Phase; Signal Transduction; Thymidine; Tyrosine | 1994 |
Okadaic acid, a serine/threonine phosphatase inhibitor, induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in A431 cells.
Topics: Alkaloids; Amino Acid Sequence; Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Kinetics; Molecular Sequence Data; Molecular Weight; Okadaic Acid; Oligopeptides; Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinase C; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor.
Topics: 3T3 Cells; Animals; Enzyme Activation; Ethers, Cyclic; Fibroblasts; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Serine; Threonine; Tyrosine | 1994 |
UV radiation induces DNA fragmentation and cell death in B16 melanoma sensitized by bromodeoxyuridine: impaired c-jun induction and defective tyrosine phosphorylation signalling.
Topics: Animals; Bromodeoxyuridine; Cell Death; Cell Survival; DNA Damage; DNA, Neoplasm; Ethers, Cyclic; Genes, jun; Immunoblotting; Melanoma, Experimental; Mice; Okadaic Acid; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-jun; Radiation-Sensitizing Agents; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Ultraviolet Rays; Vanadates | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Tyrosine phosphorylation induced by cross-linking of Fc gamma-receptor type II in human neutrophils.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cross-Linking Reagents; Egtazic Acid; Ethers, Cyclic; Genistein; Humans; Isoflavones; Molecular Sequence Data; Neutrophils; Okadaic Acid; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, IgG; Respiratory Burst; Tyrosine; Virulence Factors, Bordetella | 1995 |
Tyrosine phosphorylation of p34cdc2 is regulated by protein phosphatase 2A in growing immature Xenopus oocytes.
Topics: Animals; CDC2 Protein Kinase; Cyclins; Enzyme Activation; Ethers, Cyclic; Female; Homeostasis; Humans; Microinjections; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphotyrosine; Protamine Kinase; Protein Binding; Protein Phosphatase 2; Tyrosine; Xenopus laevis | 1995 |
Functional link between phosphorylation state of membrane proteins and morphological changes of human erythrocytes.
Topics: Anion Exchange Protein 1, Erythrocyte; Erythrocyte Membrane; Ethers, Cyclic; Humans; Membrane Proteins; Microscopy, Electron, Scanning; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Spectrin; Tyrosine; Vanadates | 1995 |
The mitogen-activated protein kinase cascade in rat islets of Langerhans.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Ethers, Cyclic; Glucose; Islets of Langerhans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Ion Exchange; Ethers, Cyclic; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Isoflavones; Neutrophils; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine | 1993 |
Effect of okadaic acid on apo B and apo A-I secretion by CaCo-2 cells.
Topics: Apolipoprotein A-I; Apolipoproteins B; Cell Line; Ethers, Cyclic; Humans; Intestines; Okadaic Acid; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Biosynthesis; RNA, Messenger; Tyrosine | 1993 |
Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line.
Topics: Animals; Cell Line; Ethers, Cyclic; Interleukin-2; Kinetics; Mice; Okadaic Acid; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; T-Lymphocytes, Cytotoxic; Tyrosine; Vanadates | 1993 |
Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Ethers, Cyclic; Gene Expression; Genes, fos; Glycosylation; Guanosine Triphosphate; Insulin; Nerve Growth Factors; Okadaic Acid; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins p21(ras); Rats; Receptor, Insulin; Signal Transduction; Tyrosine | 1993 |
Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; Indoles; Isoenzymes; Macrophages, Peritoneal; Maleimides; Mice; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Zymosan | 1994 |
Platelet-derived growth factor isoforms prevent cell death during starvation of AKR-2B fibroblasts.
Topics: Animals; Catechols; Cell Death; Cell Division; Cell Line; Cell Survival; Ethers, Cyclic; Fibroblasts; Flow Cytometry; Nitriles; Okadaic Acid; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tyrosine; Tyrphostins | 1994 |
Phenylarsine oxide and phorbol myristate acetate inhibit the CD3-induced rise of cytosolic Ca2+ in Jurkat cells by refilling internal Ca2+ stores.
Topics: Arsenicals; Biological Transport; Calcium; CD3 Complex; Cell Line; Cytosol; Ethers, Cyclic; Humans; Ionomycin; Okadaic Acid; Phosphatidylserines; Phosphorylation; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tyrosine | 1994 |
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Topics: 3T3 Cells; Adipocytes; Animals; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, Insulin; Serine; Signal Transduction; Threonine; Tyrosine | 1994 |
Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes.
Topics: Adipose Tissue; Animals; Biological Transport; Deoxyglucose; Ethers, Cyclic; Insulin; Insulin Antagonists; Insulin-Like Growth Factor II; Male; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 2; Tyrosine | 1993 |
Mitogen-activated protein kinase (MAP kinase) activation in Xenopus oocytes: roles of MPF and protein synthesis.
Topics: Animals; Enzyme Activation; Ethers, Cyclic; Female; In Vitro Techniques; Maturation-Promoting Factor; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Oocytes; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tyrosine; Xenopus laevis | 1993 |
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate.
Topics: B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Chromatography, Gel; Enzyme Activation; Ethers, Cyclic; Humans; Immunoglobulin M; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Okadaic Acid; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins.
Topics: Amino Acid Sequence; Cysteine; DNA Mutational Analysis; Drug Resistance; Enzyme Inhibitors; Ethers, Cyclic; Molecular Sequence Data; Okadaic Acid; Phosphoprotein Phosphatases; Protein Binding; Protein Phosphatase 1; Structure-Activity Relationship; Toxins, Biological; Tyrosine | 1996 |
Okadaic acid exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes. Evidence for a phosphatidylinositol 3-kinase-independent pathway.
Topics: Adipocytes; Amino Acid Sequence; Biological Transport; Cell Compartmentation; Cell Membrane; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Glucose; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Muscle Proteins; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Tyrosine | 1996 |
Serine/threonine dephosphorylation may be involved in tyrosine phosphorylation: a new mode of signal transduction in platelets.
Topics: Blood Platelets; Humans; Okadaic Acid; Phosphorylation; Platelet Aggregation; Serine; Signal Transduction; Threonine; Tyrosine | 1996 |
Regulation of natural killer cell-mediated cytotoxicity by serine/threonine phosphatases: identification of a calyculin A-sensitive serine/threonine kinase.
Topics: CD28 Antigens; Cell Line; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Enzyme Stability; Ionophores; Killer Cells, Natural; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.
Topics: Animals; Biological Transport; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Phosphatase 1; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tyrosine | 1996 |
Total inhibition of phospholipase C and phosphatidylinositol 3-kinase by okadaic acid in thrombin-stimulated platelets.
Topics: Blood Platelets; Blood Proteins; Enzyme Inhibitors; Fibrinogen; Humans; Mitogens; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Glycoprotein GPIIb-IIIa Complex; Precipitin Tests; Thrombin; Type C Phospholipases; Tyrosine | 1997 |
Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kappaB activation.
Topics: Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; DNA; HL-60 Cells; Humans; Hydrolysis; Interleukin-8; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NF-kappa B; Okadaic Acid; Phosphorylation; RNA, Messenger; Tyrosine; Vanadates | 1997 |
Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase.
Topics: Amino Acid Sequence; Antigens, CD; Binding Sites; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Okadaic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Vanadates | 1997 |
Caffeine overrides the S-phase cell cycle block in sea urchin embryos.
Topics: Animals; Aphidicolin; Caffeine; Calcium; CDC2 Protein Kinase; Cell Division; Cyclic AMP; Dimethyl Sulfoxide; DNA Replication; Embryo, Nonmammalian; Enzyme Activation; G2 Phase; Mitosis; Okadaic Acid; Phosphorylation; Protein Kinases; S Phase; Sea Urchins; Tyrosine | 1997 |
The marine toxin okadaic acid reduces O2- generation and tyrosine phosphorylation in LPS-primed rat neutrophils.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lipopolysaccharides; Male; Neutrophils; Okadaic Acid; Oxygen; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine | 1997 |
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Receptor, Insulin; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments.
Topics: Acetylation; Animals; Carbazoles; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Indole Alkaloids; Intermediate Filaments; Kidney; Microtubules; Okadaic Acid; Paclitaxel; Phosphoprotein Phosphatases; Phosphorylation; Tyrosine; Vimentin | 1998 |
Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library.
Topics: Animals; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line; Cell Transformation, Viral; Down-Regulation; Enzyme Inhibitors; Female; Insulin-Like Growth Factor I; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pregnancy; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, IGF Type 1; Signal Transduction; Structure-Activity Relationship; Tyrosine; Vanadates | 1998 |
Tyrosine phosphorylation/dephosphorylation controls capping of Fcgamma receptor II in U937 cells.
Topics: Arsenicals; Bacterial Proteins; Benzoquinones; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoblotting; Lactams, Macrocyclic; Microscopy, Fluorescence; Okadaic Acid; Phosphorylation; Quinones; Receptor Aggregation; Receptors, IgG; Rifabutin; Streptolysins; Temperature; Time Factors; Tyrosine; U937 Cells; Vanadates | 1999 |
Activation of the mitogen-activated protein kinase ERK1 during meiotic progression of mouse pachytene spermatocytes.
Topics: Animals; CDC2 Protein Kinase; Cells, Cultured; Chromosomes; Cyclin B; Cyclin B1; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Male; Meiosis; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Okadaic Acid; Phosphorylation; Spermatocytes; Subcellular Fractions; Tyrosine | 1999 |
Distinct, constitutively active MAPK phosphatases function in Xenopus oocytes: implications for p42 MAPK regulation In vivo.
Topics: Animals; Enzyme Activation; Kinetics; MAP Kinase Kinase 1; Meiosis; Microinjections; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Threonine; Tyrosine; Vanadates; Xenopus | 1999 |
Intracellular signalling pathways of okadaic acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors: okadaic acid regulates Shc phosphorylation by mechanisms independent of insulin.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; DNA; Enzyme Inhibitors; Fibroblasts; GRB2 Adaptor Protein; Insulin; Intracellular Fluid; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mitogens; Okadaic Acid; Phosphorylation; Proteins; Rats; Receptor, Insulin; src Homology Domains; Time Factors; Tyrosine | 1999 |
Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells.
Topics: Animals; Benzoquinones; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Insulin Receptor Substrate Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rifabutin; Tyrosine | 2000 |
Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells.
Topics: Adrenomedullin; Animals; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glomerular Mesangium; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Thymidine; Tyrosine | 2000 |
A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice.
Topics: Animals; Base Sequence; Cells, Cultured; Cyclin A; Cyclin A1; DNA Primers; G2 Phase; Male; Maturation-Promoting Factor; Meiosis; Mesothelin; Mice; Mice, Inbred C57BL; Mitosis; Okadaic Acid; Phosphorylation; Spermatocytes; Testis; Tyrosine | 2000 |
Okadaic acid-induced upregulation of nitrotyrosine and heme oxygenase-1 in rat cortical neuron cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Neurons; Okadaic Acid; Phosphorylation; Rats; Tyrosine; Up-Regulation | 2001 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor.
Topics: Amino Acid Sequence; Animals; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Okadaic Acid; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 2001 |
Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Hematopoietic Stem Cells; Interleukin-3; Janus Kinase 2; Macromolecular Substances; Mice; Milk Proteins; Models, Biological; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2001 |
Ceramide accelerates dephosphorylation of extracellular signal-regulated kinase 1/2 to decrease prostaglandin D(2) production in RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Cell Line; Ceramides; Dose-Response Relationship, Drug; Immunoblotting; Mast Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phospholipase D; Phospholipases A; Phosphorylation; Prostaglandin D2; Protein Tyrosine Phosphatases; Rats; Tumor Cells, Cultured; Tyrosine; Vanadates | 2001 |
The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis.
Topics: Animals; Cell Line; Cytoplasm; Humans; Mice; Okadaic Acid; Phagocytosis; Signal Transduction; Tyrosine | 2002 |
Mechanism of inhibition of insulin-stimulated glucose transport by 4-bromocrotonic acid in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Crotonates; Glucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Ionophores; Isoenzymes; Mice; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tyrosine | 2003 |
Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets.
Topics: Amino Acid Motifs; Blood Platelets; Blotting, Western; Cross-Linking Reagents; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Peptides; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Signal Transduction; Threonine; Time Factors; Tyrosine; Vanadates | 2003 |
Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
Topics: 14-3-3 Proteins; 3T3 Cells; Amino Acid Motifs; Animals; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Genetic Vectors; Glutathione Transferase; Humans; Ligands; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Okadaic Acid; Phosphorylation; Phosphoserine; Phosphothreonine; Plasmids; Precipitin Tests; Prolactin; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Prolactin; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Threonine; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Insulin attenuates leptin-induced STAT3 tyrosine-phosphorylation in a hepatoma cell line.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Insulin; Janus Kinase 2; Leptin; Liver Neoplasms; Mice; Okadaic Acid; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, Insulin; Receptors, Cell Surface; Receptors, Leptin; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine | 2003 |
Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules.
Topics: Animals; Carboxypeptidases; Catalase; COS Cells; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Immunoblotting; Microscopy, Fluorescence; Microtubules; Okadaic Acid; Paclitaxel; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Phosphatase 1; Temperature; Tyrosine | 2003 |
Ocadaic acid treatment causes tyrosine phosphorylation of caveolin-2 and induces internalization of caveolae in rat peritoneal macrophages.
Topics: Animals; Caveolae; Caveolin 2; Caveolins; Macrophages, Peritoneal; Male; Okadaic Acid; Phosphorylation; Rats; Tyrosine | 2004 |
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Middle Aged; Okadaic Acid; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Time Factors; Tyrosine | 2005 |
Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation.
Topics: Androstadienes; Benzamides; Butadienes; Extracellular Signal-Regulated MAP Kinases; Fetal Blood; Humans; Hydrogen Peroxide; Male; MAP Kinase Kinase 1; Methionine; Nitric Oxide; Nitriles; Okadaic Acid; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Recombinant Proteins; Serum Albumin, Bovine; Sperm Capacitation; Tyrosine; Wortmannin | 2006 |
Rac GTPase signaling through the PP5 protein phosphatase.
Topics: Amino Acid Sequence; Animals; Cell Line; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ion Channel Gating; Models, Molecular; Molecular Sequence Data; Nuclear Proteins; Okadaic Acid; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Potassium Channels, Voltage-Gated; Protein Structure, Quaternary; rac GTP-Binding Proteins; Rats; Sequence Alignment; Signal Transduction; Thyroid Hormones; Tyrosine | 2006 |
Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons.
Topics: Animals; Calcium; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tyrosine | 2006 |
Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes.
Topics: Androstadienes; Angiotensin II; Animals; Cell Membrane; Genistein; Insulin; Insulin Receptor Substrate Proteins; Liver; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tyrosine; Vasoconstrictor Agents; Wortmannin | 2006 |
Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules.
Topics: Acetylation; Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Mice; Microtubules; Mutation; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 2; RNA Interference; Transfection; Tyrosine | 2007 |
Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons.
Topics: Acetylation; Alzheimer Disease; Animals; Biological Transport; Calcium Chloride; Calcium Hydroxide; Cells, Cultured; Cerebral Cortex; Drug Combinations; Dyneins; Enzyme Inhibitors; Microtubules; Neurons; Okadaic Acid; Phosphorylation; Potassium Chloride; Protein Phosphatase 2; Protein Processing, Post-Translational; Rats; Sodium Bicarbonate; Sodium Chloride; Tubulin; Tyrosine | 2008 |
Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.
Topics: Aniline Compounds; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Indoles; Male; Marine Toxins; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nitriles; Okadaic Acid; Oxazoles; Phosphorylation; Protein Serine-Threonine Kinases; Quinolines; Signal Transduction; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; src-Family Kinases; Sulfonamides; Tyrosine | 2010 |
Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility.
Topics: Animals; Catalysis; Cattle; DNA Methylation; Epididymis; Glycogen Synthase Kinase 3; Homocysteine; Leucine; Male; Methylation; Microcystins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Structure, Tertiary; Sepharose; Sperm Maturation; Sperm Motility; Spermatozoa; Tyrosine | 2015 |
Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.
Topics: Analysis of Variance; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Glycosides; HEK293 Cells; Humans; Neuroblastoma; Okadaic Acid; Phosphorylation; Protein Phosphatase 2; RNA, Small Interfering; tau Proteins; Transfection; Tyrosine | 2016 |
A robust colorimetric aptasensor for the label-free detection of marine toxins based on tyrosine-capped gold nanoparticles.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Colorimetry; Gold; Humans; Limit of Detection; Metal Nanoparticles; Okadaic Acid; Tyrosine | 2022 |