tyrosine has been researched along with methotrexate in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertolone, S; Hilton, MA; Patel, CC | 1 |
| Benkovic, SJ; Singh, UC | 1 |
| Badr, MZ; Chen, TS | 2 |
| Jungkind, DL; Wood, RC | 1 |
| D'Angelo, GL; McQueen, CA; Musacchio, JM | 1 |
| Evans, EA | 1 |
| Lo, GS; Longenecker, JB | 1 |
| Newman, EM; Nierenberg, DW; Santi, DV | 1 |
| Bertolone, SJ; Clark, LW; Hilton, MA; Kmetz, DR; Patel, CC | 1 |
| James, RI; May, C; McIvor, RS; Studebaker, R; Vagt, MD | 1 |
| Bhushan, A; Hacker, MP; Tritton, TR | 1 |
| Klos, KS; Shi, D; Smith, TL; Yang, W; Yang, Y; Yao, J; Yu, D; Zhou, X | 1 |
| Desaki, M; Kawasaki, S; Kohyama, T; Okazaki, H; Takizawa, H; Yamamoto, K; Yamauchi, Y | 1 |
| Abraham, P; Kolli, VK; Rabi, S | 1 |
| Hamada, K; Horie, T; Sekine, S; Shitara, Y | 1 |
| Bellaguarda, EA; Braga-Neto, MB; Brito, GA; Freire, RS; Gomes, AS; Leitão, RF; Lima-Júnior, RC; Oriá, RB; Ribeiro, RA; Silva, JV; Siqueira, FJ; Vale, ML | 1 |
| Abraham, P; Faith, M; Isaac, B; Kanakasabapathy, I; Kolli, VK; Natarajan, K; Ramamoorthy, H | 1 |
| Allweis, TM; Axelrod, JH; Daum, H; Galun, E; Hamburger, T; Kadouri, L; Katz, D; Maly, B; Nechushtan, H; Peretz, T; Sonnenblick, A; Uziely, B | 1 |
| Agbenowu, S; Bearden, SE; Bhushan, A; Cao, S; Daniels, CK; Lai, JCK; Li, M; Liu, T; Rios, Z; Sheridan, PP; Singh, R | 1 |
| Fiser, A; Goldman, ID; Najmi, M; Unal, ES; Visentin, M; Zhao, R | 1 |
| Madhuri, R; Patra, S; Roy, E; Sharma, PK | 1 |
| Abraham, P; Natarajan, K | 1 |
| Nakamura, H; Sato, S; Tsushima, M | 1 |
24 other study(ies) available for tyrosine and methotrexate
| Article | Year |
|---|---|
Daily profiles of plasma phenylalanine and tyrosine in patients with osteogenic sarcoma during treatment with high-dose methotrexate-citrovorum rescue.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Leg; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine | 1989 |
A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductase.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Methotrexate; Mutation; Phenylalanine; Tetrahydrofolate Dehydrogenase; Tyrosine; Valine | 1988 |
Prevention of methotrexate-induced gastrointestinal toxicity by glucose.
Topics: Animals; Biological Transport; Digestive System; Glucose; Intestinal Absorption; Male; Methotrexate; Mice; Tyrosine | 1987 |
Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Drug Synergism; Glucose; In Vitro Techniques; Intestinal Absorption; Male; Methotrexate; Mice; Tyrosine; Vincristine | 1985 |
Physiological differences between cyclopropane fatty acid-deficient mutants and the parent strain of Streptococcus faecalis.
Topics: Cell Division; Cell Survival; Chromatography, Thin Layer; Cyclopropanes; Deoxycholic Acid; Drug Resistance, Microbial; Enterococcus faecalis; Fatty Acids; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; Pantothenic Acid; Sodium Chloride; Species Specificity; Temperature; Thymidine; Time Factors; Tyrosine | 1974 |
Dihydropteridine reductase: implication on the regulation of catecholamine biosynthesis.
Topics: Adrenal Glands; Animals; Catecholamines; Cattle; Dihydroxyphenylalanine; Epinephrine; Feedback; Hydrolases; In Vitro Techniques; Methotrexate; Oxidoreductases; Pteridines; Spectrophotometry; Tyrosine | 1971 |
Control of self-irradiation decomposition of tritium-labelled compounds at high specific activity.
Topics: Alcohols; Drug Stability; Ethanol; Folic Acid; Formates; Histidine; Leucine; Methotrexate; Nucleosides; Penicillin G; Radiation-Protective Agents; Thymidine; Tritium; Tyrosine; Uridine | 1966 |
Induction of an experimental phenylketonuria-like condition in infant rats during the first 2 weeks after birth.
Topics: Animals; Animals, Newborn; Diet; Disease Models, Animal; Female; Fenclonine; Humans; Male; Methotrexate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine | 1981 |
Selective killing of transformed cells by methotrexate with histidine deprivation or with alpha-amino alcohols.
Topics: Animals; Cell Division; Cell Survival; Histidine; Histidinol; Imidazoles; Methotrexate; Mice; Mice, Inbred BALB C; Phenylalanine; Tyrosine | 1983 |
Plasma phenylalanine: tyrosine ratios during high-dose methotrexate-citrovorum "rescue".
Topics: Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine | 1982 |
Transgenic mice expressing the tyr22 variant of murine DHFR: protection of transgenic marrow transplant recipients from lethal doses of methotrexate.
Topics: Amino Acid Substitution; Animals; Bone Marrow Transplantation; Colony-Forming Units Assay; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Hematopoiesis; Methotrexate; Mice; Mice, Transgenic; RNA, Messenger; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tyrosine | 1997 |
Collateral methotrexate resistance in cisplatin-selected murine leukemia cells.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Resistance, Neoplasm; Leukemia L1210; Methotrexate; Mice; Phosphorylation; Tyrosine | 1999 |
ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 over
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; CDC2 Protein Kinase; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclophosphamide; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Immunohistochemistry; Methotrexate; Middle Aged; Phosphorylation; Receptor, ErbB-2; RNA, Messenger; Tyrosine; Up-Regulation | 2003 |
Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.
Topics: Acetylcysteine; Bronchi; Cell Line; Cycloheximide; Epithelial Cells; Folic Acid Antagonists; Free Radical Scavengers; Glucose; Humans; Hypoglycemia; Interleukin-1; Interleukin-8; Lipopolysaccharides; Methotrexate; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Pulmonary Alveoli; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Duodenum; Ileum; Immunohistochemistry; Injections, Intraperitoneal; Intestine, Small; Jejunum; Male; Methotrexate; Neutrophil Infiltration; Neutrophils; Nitrites; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reactive Nitrogen Species; Time Factors; Tyrosine | 2008 |
Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.
Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Western; Dextrans; Fluorescein-5-isothiocyanate; Immunohistochemistry; Immunoprecipitation; Inflammation; Intestinal Mucosa; Intestine, Small; Luminescence; Male; Membrane Proteins; Methotrexate; Permeability; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions; Tyrosine; Zonula Occludens-1 Protein | 2010 |
Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents.
Topics: Animals; Cell Death; Cell Proliferation; Enzyme Inhibitors; Guanidines; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Ki-67 Antigen; Male; Methotrexate; Mice; Mice, Knockout; Mucositis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Tyrosine | 2011 |
A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation.
Topics: Animals; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Enterocolitis; Intestinal Mucosa; Intestine, Small; Male; Melatonin; Methotrexate; Nitrates; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine | 2013 |
Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Methotrexate; Middle Aged; Multivariate Analysis; Phosphorylation; Proportional Hazards Models; Protein Processing, Post-Translational; STAT3 Transcription Factor; Treatment Outcome; Tyrosine | 2013 |
Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.
Topics: Animals; Drug Resistance, Neoplasm; HSC70 Heat-Shock Proteins; Leukemia L1210; Methotrexate; Mice; Microscopy, Confocal; Phosphorylation; Reduced Folate Carrier Protein; Tyrosine | 2015 |
Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Biological Transport; Cell Line, Tumor; Folic Acid; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Methotrexate; Models, Molecular; Pemetrexed; Protein Structure, Tertiary; Proton-Coupled Folate Transporter; Tyrosine | 2015 |
Stimuli-responsive poly(N-isopropyl acrylamide)-co-tyrosine@gadolinium: Iron oxide nanoparticle-based nanotheranostic for cancer diagnosis and treatment.
Topics: Acrylic Resins; Antimetabolites, Antineoplastic; Biological Transport; Cell Line; Contrast Media; Drug Carriers; Drug Compounding; Drug Liberation; Ferric Compounds; Fibroblasts; Gadolinium; Humans; Hydrogen-Ion Concentration; Hyperthermia, Induced; Magnetic Fields; Magnets; MCF-7 Cells; Methotrexate; Nanoparticles; Organ Specificity; Temperature; Theranostic Nanomedicine; Tyrosine | 2016 |
Methotrexate administration induces differential and selective protein tyrosine nitration and cysteine nitrosylation in the subcellular organelles of the small intestinal mucosa of rats.
Topics: Animals; Blotting, Western; Cysteine; Cytosol; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mitochondrial Proteins; Nuclear Proteins; Proteins; Rats; Rats, Wistar; Tyrosine | 2016 |
Selective purification and chemical labeling of a target protein on ruthenium photocatalyst-functionalized affinity beads.
Topics: Benzenesulfonamides; Biotin; Catalysis; Free Radicals; HeLa Cells; Humans; Methotrexate; Organometallic Compounds; Photochemical Processes; Ruthenium; Sulfonamides; Surface Properties; Tetrahydrofolate Dehydrogenase; Tyrosine | 2017 |