tyrosine has been researched along with losartan potassium in 125 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.60) | 18.7374 |
| 1990's | 75 (60.00) | 18.2507 |
| 2000's | 40 (32.00) | 29.6817 |
| 2010's | 7 (5.60) | 24.3611 |
| 2020's | 1 (0.80) | 2.80 |
| Authors | Studies |
|---|---|
| Quelle, DE; Quelle, FW; Wojchowski, DM | 1 |
| Billat, C; Casadevall, N; Dusanter-Fourt, I; Fischer, S; Lacombe, C; Mayeux, P; Muller, O | 1 |
| Adamson, JW; Altschuler, D; Komatsu, N; Lapetina, EG; Marzocchini, R; Torti, M; Yamamoto, K | 1 |
| D'Andrea, A; Evans, GA; Farrar, WL; Linnekin, D | 1 |
| Damen, J; Hughes, P; Humphries, K; Krystal, G; Mui, AL | 1 |
| Arima, N; Hattori, T; Imada, K; Itoh, K; Kodaka, T; Okuma, M; Tsudo, M; Uchiyama, T | 1 |
| Evans, G; Farrar, WL; Linnekin, D; Michiel, D | 1 |
| Altschuler, D; Lapetina, EG; Marti, KB; Torti, M; Yamamoto, K | 1 |
| D'Andrea, A; Ihle, JN; Kabat, D; Miura, O | 1 |
| Amanuma, H; Chiba, T; Kuramochi, S; Todokoro, K; Tojo, A | 1 |
| Quelle, FW; Wojchowski, DM | 1 |
| Asano, K; Kozutsumi, H; Satake, R; Takeuchi, M | 1 |
| Banerjee, RK; Datta, AG; Ray, PK | 1 |
| Aranzulla, G; Folco, U; Fresco, G; Gambaro, GC | 1 |
| David, M; Feldman, GM; Fibach, E; Finbloom, DS; Hackett, RH; Igarashi, K; Petricoin, EF; Silva, CM; Thorner, MO; Weber, MJ | 1 |
| Dusanter, I; Gisselbrecht, S; Gobert, S; Lacombe, C; Mayeux, P; Muller, O | 1 |
| Farrell, FX; Lapetina, EG | 1 |
| Ikawa, Y; Noda, M; Yamamura, Y | 1 |
| Nakaya, K; Nishida, E; Sugiyama, M; Todokoro, K | 1 |
| Aoki, N; Ihle, JN; Miura, O; Miura, Y; Nakamura, N; Quelle, FW; Witthuhn, BA | 1 |
| Ihle, JN; Miura, O; Yi, T; Zhang, J | 1 |
| Bagby, GC; Broxmeyer, HE; Feng, GS; Hoatlin, M; Kabat, D; Lu, L; Shen, R; Tauchi, T | 1 |
| Hanazono, Y; Hirai, H; Nitta, H; Sasaki, K; Yazaki, Y | 1 |
| Hanazono, Y; Hirai, H; Iwamatsu, A; Mitani, K; Odai, H; Sasaki, K; Tanaka, T; Yazaki, Y | 1 |
| He, TC; Jiang, N; Wojchowski, DM; Zhuang, H | 1 |
| Courtois, G; Dusanter-Fourt, I; Gisselbrecht, S; Gobert, S; Lacombe, C; Mayeux, P; Muller, O; Pallu, S; Porteu, F; Sabbah, M | 1 |
| Bittorf, T; Busfield, SJ; Callus, B; Cull, VS; Klinken, SP; Tilbrook, PA | 1 |
| Besmer, P; Klingmüller, U; Lodish, HF; Wu, H | 1 |
| Cutler, RL; Damen, JE; Jiao, H; Krystal, G; Yi, T | 1 |
| Chiba, S; Hanazono, Y; Hirai, H; Mano, H; Sasaki, K; Yazaki, Y | 1 |
| Cutler, RL; Damen, JE; Krystal, G; Liu, L | 2 |
| Cantley, LC; Klingmüller, U; Lodish, HF; Lorenz, U; Neel, BG | 1 |
| Bierer, BE; Calvo, V; Gjertson, C; Vik, T; Wood, M | 1 |
| Aoki, N; Ihle, JN; Miura, O; Miura, Y | 1 |
| Yoshimura, A | 1 |
| Aoki, N; Ihle, JN; Miura, O; Nakamura, N | 1 |
| Ihle, JN; Miura, O; Quelle, FW; Silvennoinen, O; Tang, B; Witthuhn, BA; Yi, T | 1 |
| Druker, B; Dusanter-Fourt, I; Fischer, S; Gisselbrecht, S; Lacombe, C; Mauduit, P; Mayeux, P; Muller, O; Sabbah, M; Vainchenker, W | 1 |
| Cutler, RL; Damen, JE; Humphries, RK; Krosl, J; Krystal, G; Miyajima, A; Wakao, H | 1 |
| Kato, T; Komatsu, N; Miura, Y; Miyazaki, H; Okada, K; Yamada, M | 1 |
| Duprez, V; Gisselbrecht, S; Gobert, S; Lacombe, C; Mayeux, P | 1 |
| Penta, K; Sawyer, ST | 2 |
| Broxmeyer, HE; Damen, JE; Feng, GS; Krystal, G; Tauchi, T; Toyama, K | 1 |
| Ihle, JN; Nosaka, T; Quelle, FW; Stravopodis, D; Thierfelder, WE; Wang, D; Weinstein, Y | 1 |
| Barbone, FP; Barrett, RW; Chang, R; Dower, WJ; Farrell, FX; Johnson, DL; Jolliffe, LK; Kashyap, AK; Mulcahy, LS; Wrighton, NC | 1 |
| Collins, A; Gruninger, RH; Jin, R; Johnson, DL; Jolliffe, LK; McMahon, FJ; Middleton, SA; Mulcahy, LS; Tullai, J | 1 |
| Chretien, S; Dusanter-Fourt, I; Gisselbrecht, S; Gobert, S; Gouilleux, F; Groner, B; Lacombe, C; Mayeux, P; Muller, O; Pallard, C | 1 |
| Hanazono, Y; Hirai, H; Iwamatsu, A; Odai, H; Sasaki, K; Yazaki, Y | 1 |
| Gaffen, SL; Goldsmith, MA; Greene, WC; Ha, M; Hennighausen, L; Lai, SY; Liu, X | 1 |
| Davis-Amaral, EM; Goldstein, L; Musch, MW | 1 |
| Christel, C; Dannenberg, L; Haller, H; Lindschau, C; Luft, FC; Thiele, P | 1 |
| Davis, KL; Li, Y; Sytkowski, AJ | 1 |
| Acurio, A; Hsiao, JG; Klingmüller, U; Lodish, HF; Wu, H | 1 |
| Jacobs-Helber, SM; Lawson, A; Penta, K; Sawyer, ST; Sun, Z | 1 |
| Cantley, LC; Duckworth, BC; Hsiao, JG; Klingmüller, U; Lodish, HF; Toker, A; Wu, H | 1 |
| Chida, D; Damen, JE; Krystal, G; Miyajima, A; Wakao, H | 1 |
| Kirito, K; Komatsu, N; Miura, Y; Uchida, M; Yamada, M | 1 |
| Damen, JE; Humphries, RK; Jefferson, AB; Krosl, J; Krystal, G; Liu, L; Majerus, PW; Miyajima, A; Rosten, P; Wakao, H | 1 |
| Billat, C; Chrétien, S; Gisselbrecht, S; Lacombe, C; Mayeux, P; Verdier, F | 1 |
| Arai, A; Chin, H; Kamiyama, R; Miura, O; Miyasaka, N; Saito, T; Yamamoto, K | 1 |
| Higuchi, M; Imai, N; Kondo, T; Kuriyama, K; Miyazaki, Y; Saito, M; Sohda, H; Tomonaga, M; Tsushima, H | 1 |
| Goldsmith, MA; Lai, SY; Liu, KD; Longmore, GD; Mikami, A; Molden, J; Pharr, P; You, Y | 1 |
| Ikawa, Y; Kageyama, Y; Matsuzaki, T; Noda, M; Senda, H; Yamamura, Y | 1 |
| Barbone, FP; Dower, WJ; Farrell, FX; Hoey, K; Johnson, DL; Jolliffe, LK; Livnah, O; Loughney, DA; McMahon, FJ; Middleton, SA; Mulcahy, LS; Stura, EA; Tullai, J; Wilson, IA; Wrighton, NC | 1 |
| Eaton, DC; Ling, BN; Ma, H; Marrero, MB; Venema, RC | 1 |
| Druker, BJ; Fukada, Y; Handa, M; Ikeda, Y; Koike, T; Koizumi, K; Oda, A; Ozaki, K; Sawada, K; Takano, H | 1 |
| Hashimoto, K; Ishikawa, J; Kanakura, Y; Matsumura, I; Matsuzawa, Y; Nishiura, T; Okajima, Y; Tomiyama, Y; Wakao, H; Yoshida, H; Yoshimura, A | 1 |
| Barbone, FP; Farrell, FX; Goldsmith, MA; He, W; Johnson, DL; Jolliffe, LK; Krause, CD; Liu, KD; Livnah, O; Pestka, S; Stura, EA; Wilson, IA; You, Y | 1 |
| Kimura, F; Motoyoshi, K; Nagata, N; Nakamura, Y; Ota, J; Sato, K; Shimamura, S; Suzu, S; Wakimoto, N; Yamada, M | 1 |
| Druker, BJ; Handa, M; Ikeda, Y; Ishida, A; Komatsu, N; Miyajima, A; Morita, K; Oda, A; Ohashi, H; Okamoto, S; Ozaki, K; Rhodes, J; Wakao, H; Wakui, M | 1 |
| Arcasoy, MO; Forget, BG; Harris, KW | 1 |
| Inoue, A; Komiya, S; Mitsui, K; Sasaki, A; Wakioka, T; Yokouchi, M; Yoshimura, A | 1 |
| Cases, A; Castillo, R; Diaz-Ricart, M; Escolar, G; Etebanell, E; López-Pedret, J; Ordinas, A | 1 |
| Billat, C; Boudot, C; Chretien, S; Haye, B; Kadri, Z; Mayeux, P; Petitfrère, E | 1 |
| Barber, DL; Beattie, BK; Dumont, DJ; Liu, Q; Mason, JM | 1 |
| Hanson, C; Muszynski, K; Nishigaki, K; Ohashi, T; Ruscetti, S; Thompson, D | 1 |
| Chretien, S; Gisselbrecht, S; Hubert, N; Lacombe, C; Mayeux, P; Verdier, F; Walrafen, P | 1 |
| Fan, L; Goldwasser, E; Kung, C | 1 |
| Akimoto, T; Ando, Y; Asano, Y; Iimura, O; Ikeda, H; Inaba, T; Ito, C; Kusano, E; Ozawa, K; Takahashi, H | 1 |
| Liu, C; Nicolas-Metral, V; Noguchi, CT; Ogilvie, M; Pulido, SM; Ruegg, UT; Yu, X | 1 |
| Dai, RM; Kirken, RA; Li, CC; Ruscetti, SK; Yang, YC; Yen, CH | 1 |
| Hayde, M; Hayn, M; Herkner, K; Lombard, KA; Lubec, G; Pollak, A; Weninger, M; Widness, JA | 1 |
| Cacalano, NA; Johnston, JA; Sanden, D | 1 |
| Arai, A; Kanda, E; Miura, O; Miyasaka, N; Nosaka, Y | 1 |
| Kirito, K; Komatsu, N; Nakajima, K; Ozawa, K; Tanaka, M; Uchida, M; Watanabe, T | 1 |
| Barber, DL; Beattie, BK; Halupa, A; Haq, R; Mason, JM; Zanke, BW | 1 |
| Fan, H; Kanji, S; Zhai, M | 1 |
| Correll, PH; Finkelstein, LD; Liu, QP; Ney, PA; Paulson, RF | 1 |
| Billat, C; Boudot, C; Chrétien, S; Haye, B; Kadri, Z; Lambert, E; Mayeux, P; Petitfrère, E | 1 |
| Ang, S; Guan, Y; Jedlickova, K; Jelinek, J; Krishnamurti, L; Liu, E; Pastore, YD; Prchal, JT | 1 |
| Feng, X; Namba, N; Ross, FP; Takeshita, S; Teitelbaum, SL; Wei, S | 1 |
| Billat, C; Boudot, C; Chrétien, S; Dassé, E; Haye, B; Kadri, Z; Lambert, E; Mayeux, P; Petitfrère, E | 1 |
| Hegde, S; Li, K; Miller, C; Wojchowski, D | 1 |
| Cohen, J; Klingmuller, U; Neumann, D; Oren-Young, L | 1 |
| Inagaki, K; Iwamura, H; Komatsu, N; Naka, Y; Oda, T; Shinkai, H | 1 |
| Barber, DL; Chen, J; Jacobs-Helber, SM; Sawyer, ST | 1 |
| Cuzzocrea, S; De Sarro, A; Di Paola, R; Genovese, T; Mazzon, E; Muià, C; Patel, NS; Thiemermann, C | 1 |
| Akagi, S; Ichikawa, H; Kihara, T; Makino, H; Morimoto, H; Nagake, Y; Nakao, K; Okada, T; Sarai, A; Sugimoto, T; Wada, J; Yano, A | 1 |
| Matsuda, T; Minoguchi, M; Oritani, K; Sekine, Y; Shimoda, K; Sugiyama, K; Tsuji, S; Yamamoto, T; Yoshimura, A; Yumioka, T | 1 |
| Lu, D; Ren, H | 1 |
| Lodish, HF; Tong, W; Zhang, J | 1 |
| Britti, D; Caputi, AP; Cuzzocrea, S; de Majo, M; di Paola, R; Genovese, T; Mazzon, E; Patel, NS; Thiemermann, C | 1 |
| Barber, DL; Chohan, M; Richmond, TD | 1 |
| Fu, X; Krantz, SB; Li, Q; Li, Z; Xing, S; Zhao, R; Zhao, ZJ | 1 |
| Arcasoy, MO; Karayal, AF | 1 |
| Acs, G; Cohen, N; Dalgard, C; Lai, SY; Lu, H; Mohyeldin, A; Verma, A | 1 |
| Gilliland, DG; Tefferi, A | 1 |
| Avivi, A; Nevo, E; Shams, I | 1 |
| Correll, PH; Hao, L; Liu, Q; Ni, S; Wei, X; Xu, J | 1 |
| Correll, PH; Paulson, RF; Subramanian, A; Teal, HE | 1 |
| Höke, A; Jack, C; Lambrinos, GL; Melli, G; Ringkamp, M | 1 |
| Céspedes, C; González, AA; Velarde, V; Villanueva, S; Vio, CP | 1 |
| Barber, DL; Cheung, JY; Conrad, K; Hirschler-Laszkiewicz, I; Miller, BA; Neagley, DW; Tong, Q; Zhang, W | 1 |
| Gross, AW; Lodish, HF; Lu, X; Radhakrishnan, ML; Tidor, B; Zhang, YL | 1 |
| Feng, D; Li, X; Liu, D; Prasad, PV; Shang, Y; Xu, S; Yao, S; Yuan, S | 1 |
| Callero, MA; Chamorro, ME; Nesse, AB; Vittori, DC; Vota, DM; Wenker, SD | 1 |
| Andersson, S; Arduini, A; Asensi, MA; Cubells, E; Escobar, J; Sastre, J; Stefanovic, V; Teramo, K; Vento, M | 1 |
| Debevec, T; Eiken, O; Mekjavic, IB; Millet, GP; Mury, P; Pialoux, V | 1 |
| Kőszegi, T; Kun, S; Laczy, B; Mikolás, E; Molnár, GA; Sélley, E; Wittmann, I | 1 |
| Castañeda-Arellano, R; Feria-Velasco, AI; Rivera-Cervantes, MC | 1 |
| Aizawa, K; Endo, K; Hirata, M; Kawasaki, R; Serizawa, K; Tashiro, Y; Yogo, K | 1 |
| Choi, EJ; Jung, D; Kim, BM; Kim, JS; Lee, Y | 1 |
| Ben-Califa, N; Hengst, L; Jäkel, H; Neumann, D; Pegka, F | 1 |
2 review(s) available for tyrosine and losartan potassium
| Article | Year |
|---|---|
Rap1b and platelet function.
Topics: Amino Acid Sequence; Blood Platelets; Erythropoietin; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Iloprost; Isoenzymes; Molecular Sequence Data; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Platelet Activation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); rap GTP-Binding Proteins; ras GTPase-Activating Proteins; Sequence Homology, Amino Acid; Signal Transduction; Thrombin; Type C Phospholipases; Tyrosine | 1993 |
Turning cells red: signal transduction mediated by erythropoietin.
Topics: Animals; Calcium; Cell Differentiation; Cell Lineage; Cell Survival; Erythropoiesis; Erythropoietin; Humans; Janus Kinase 2; Ligands; Mice; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; Tyrosine | 2005 |
2 trial(s) available for tyrosine and losartan potassium
| Article | Year |
|---|---|
Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants.
Topics: Administration, Oral; Ascorbic Acid; Blood Cell Count; Drug Therapy, Combination; Erythrocyte Indices; Erythrocyte Transfusion; Erythropoiesis; Erythropoietin; Ferric Compounds; Ferric Oxide, Saccharated; Glucaric Acid; Humans; Infant, Newborn; Infant, Premature, Diseases; Infant, Very Low Birth Weight; Injections, Intravenous; Iron; Malondialdehyde; Prospective Studies; Tyrosine | 2001 |
Moderate exercise blunts oxidative stress induced by normobaric hypoxic confinement.
Topics: Adult; Advanced Oxidation Protein Products; Atmospheric Pressure; Catalase; Erythropoietin; Exercise; Exercise Test; Glutathione Peroxidase; Heart Rate; Humans; Hypoxia; Male; Malondialdehyde; Oxidative Stress; Oxygen; Physical Exertion; Superoxide Dismutase; Tyrosine; Young Adult | 2014 |
121 other study(ies) available for tyrosine and losartan potassium
| Article | Year |
|---|---|
Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells.
Topics: Animals; Cell Division; Cell Line; Cell Membrane; Cytosol; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Kinetics; Mice; Molecular Weight; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Erythropoietin; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Subcellular Fractions; Transfection; Tyrosine; Vanadates | 1992 |
Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells.
Topics: Blotting, Western; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Interleukin-3; Interleukin-6; Phosphorylation; Precipitin Tests; Receptors, Cell Surface; Receptors, Erythropoietin; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1992 |
Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7.
Topics: Erythropoietin; Guanosine Triphosphate; Hematopoiesis; Humans; In Vitro Techniques; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
Association of the erythropoietin receptor with protein tyrosine kinase activity.
Topics: Adenosine Triphosphate; Animals; Electrophoresis, Gel, Two-Dimensional; Erythropoietin; Friend murine leukemia virus; Gene Products, env; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Erythropoietin; Signal Transduction; Tyrosine | 1992 |
Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line.
Topics: Animals; B-Lymphocytes; Cell Line; Cross-Linking Reagents; DNA; Erythropoietin; Gene Expression; Immunoblotting; Interleukin-3; Kinetics; Mice; Phenylhydrazines; Phosphorylation; Phosphotyrosine; Receptors, Erythropoietin; RNA, Messenger; Signal Transduction; Transfection; Tyrosine | 1992 |
Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor beta chain cDNA.
Topics: Animals; Cell Differentiation; Erythropoietin; Humans; Interleukin-2; Kinetics; Leukemia, Erythroblastic, Acute; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Interleukin-2; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1992 |
Characterization of a 97-kDa phosphotyrosylprotein regulated by multiple cytokines.
Topics: Adenosine Triphosphate; Cell Line; Cytokines; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-2; Interleukin-3; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; T-Lymphocytes; Tyrosine | 1992 |
Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.
Topics: Electrophoresis, Polyacrylamide Gel; Erythropoietin; Genistein; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Isoflavones; Leukemia, Erythroblastic, Acute; Oncogene Protein p21(ras); Phosphorylation; Proteins; ras GTPase-Activating Proteins; Recombinant Proteins; Signal Transduction; Tyrosine | 1992 |
Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.
Topics: Amino Acid Sequence; Base Sequence; Cell Division; Cell Line; Enzyme Induction; Erythropoietin; Gene Expression Regulation; Immunoblotting; Interleukin-3; Molecular Sequence Data; Mutation; Phosphorylation; Receptors, Cell Surface; Receptors, Erythropoietin; Receptors, Interleukin-2; Sequence Homology, Nucleic Acid; Transfection; Tyrosine | 1991 |
Growth signal erythropoietin activates the same tyrosine kinases as interleukin 3, but activates only one tyrosine kinase as differentiation signal.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Erythropoietin; Interleukin-3; Kinetics; Leukemia, Experimental; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells.
Topics: Animals; Cell Division; Cell Line; Cell Membrane; Clone Cells; Erythropoietin; Interleukin-3; Kinetics; Membrane Proteins; Mice; Phosphoproteins; Tyrosine | 1991 |
Chemical modification of erythropoietin: an increase in in vitro activity by guanidination.
Topics: Arginine; Biological Assay; Erythropoiesis; Erythropoietin; Guanidines; Humans; Lysine; Recombinant Proteins; Sialic Acids; Structure-Activity Relationship; Tyrosine | 1990 |
A new biochemical effect of erythropoietin.
Topics: Animals; Chemical Phenomena; Chemistry; Chorionic Gonadotropin; Diiodotyrosine; Enzyme Activation; Erythropoietin; Humans; Hydrogen Peroxide; Iodine; Iodine Isotopes; Lactates; Monoiodotyrosine; Neuraminidase; Peroxidases; Plants; Sheep; Thyrotropin; Tyrosine | 1973 |
[Behavior and significance of plasma erythropoietin in hypothyroidism anemia].
Topics: Adult; Aged; Anemia; Basal Metabolism; Bone Marrow; Erythropoietin; Female; Humans; Hypothyroidism; Middle Aged; Tyrosine | 1970 |
Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation.
Topics: Base Sequence; Cell Line; Deoxyribonucleoproteins; DNA-Binding Proteins; Enhancer Elements, Genetic; Erythropoietin; Gene Expression Regulation; Growth Hormone; Humans; In Vitro Techniques; Molecular Sequence Data; Molecular Weight; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tyrosine | 1994 |
Intracellular pathways activated by erythropoietin.
Topics: Cell Line; Erythropoietin; Growth Substances; Hematopoietic Cell Growth Factors; Humans; Leukemia, Erythroblastic, Acute; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptors, Erythropoietin; Signal Transduction; Stem Cell Factor; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Activated Ki-Ras complements erythropoietin signaling in CTLL-2 cells, inducing tyrosine phosphorylation of a 160-kDa protein.
Topics: Cell Division; Cell Line; Erythropoietin; Genes, ras; Genes, src; Humans; Janus Kinase 2; Molecular Weight; Oncogenes; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Receptors, Erythropoietin; Signal Transduction; T-Lymphocytes, Cytotoxic; Transfection; Tyrosine | 1994 |
Activation of mitogen-activated protein kinase cascade through erythropoietin receptor.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Erythropoietin; Humans; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Phosphoproteins; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-2; Signal Transduction; Transfection; Transferrin; Tyrosine | 1994 |
Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor.
Topics: Amino Acid Sequence; Cell Cycle Proteins; Cell Line; Erythropoietin; Gene Expression Regulation; Humans; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Point Mutation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Proto-Oncogene Proteins c-vav; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine | 1994 |
Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Disulfides; Erythropoietin; Immunosorbent Techniques; Interleukin-3; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Mice; Molecular Sequence Data; Peptide Fragments; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Erythropoietin; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Tyrosine | 1995 |
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; ErbB Receptors; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Intracellular Signaling Peptides and Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Receptors, Erythropoietin; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1995 |
Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor.
Topics: Amino Acid Sequence; Cell Line; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Macromolecular Substances; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Erythropoietin; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Tyrosine | 1995 |
The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Binding Sites; Consensus Sequence; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Molecular Sequence Data; Phosphotyrosine; Protein Binding; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Sequence Alignment; Sequence Homology, Amino Acid; Tyrosine; Ubiquitin-Protein Ligases | 1995 |
Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway.
Topics: Animals; Base Sequence; Blotting, Western; Cell Division; Cell Line; DNA Primers; Enzyme Activation; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-3; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Tyrosine | 1995 |
Tyrosine phosphorylation of the erythropoietin receptor: role for differentiation and mitogenic signal transduction.
Topics: Cell Differentiation; Cell Line; Enzyme Activation; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Globins; Hematopoietic Stem Cells; Interleukin-3; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Erythropoietin; Recombinant Fusion Proteins; Sequence Deletion; Signal Transduction; Transfection; Tyrosine | 1995 |
Amiloride suppresses erythropoietin-induced proliferation and MAP kinase, but potentiates differentiation of J2E cells.
Topics: Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Erythrocytes; Erythropoietin; Genistein; Hemoglobins; Humans; Immunoblotting; Isoflavones; Kinetics; Leucine; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Thymidine; Tyrosine | 1995 |
Interaction of the erythropoietin and stem-cell-factor receptors.
Topics: Animals; Cell Division; Cell Line; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Hematopoietic Cell Growth Factors; Humans; Mice; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Recombinant Fusion Proteins; Signal Transduction; Stem Cell Factor; Tyrosine | 1995 |
Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Line; Cricetinae; Erythropoietin; Humans; In Vitro Techniques; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Conformation; Receptors, Erythropoietin; Recombinant Fusion Proteins; Tyrosine | 1995 |
Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells.
Topics: Amino Acid Sequence; Blotting, Western; Cell Differentiation; Cell Division; Erythropoietin; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosorbent Techniques; Interleukin-3; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Tumor Cells, Cultured; Tyrosine | 1993 |
Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Cricetinae; Cytokines; ErbB Receptors; Erythropoietin; GRB2 Adaptor Protein; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Interleukin-3; Mice; Phosphorylation; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stem Cell Factor; Tyrosine | 1993 |
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
Topics: Animals; B-Lymphocytes; Bone Marrow Cells; Cell Division; Cell Line; Cytoplasm; Enzyme Activation; Erythropoietin; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Mice; Phosphorylation; Point Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 1995 |
Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation.
Topics: Animals; Carrier Proteins; Cell Cycle; Cell Division; Cells, Cultured; Enzyme Activation; Erythropoietin; Heat-Shock Proteins; Interleukin-3; Mice; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus Binding Proteins; Tyrosine | 1994 |
Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.
Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Erythropoietin; GRB2 Adaptor Protein; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptors, Erythropoietin; Signal Transduction; Tyrosine | 1994 |
Second subunit of Epo receptor?
Topics: Cell Line; Erythropoietin; Phosphorylation; Receptors, Erythropoietin; Recombinant Fusion Proteins; Tyrosine | 1994 |
Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor.
Topics: Binding Sites; Cell Line; Erythropoietin; Interleukin-3; Kinetics; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptors, Erythropoietin; Signal Transduction; Tyrosine | 1994 |
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
Topics: 3T3 Cells; Animals; Cell Division; Enzyme Activation; Erythropoietin; Janus Kinase 2; Mice; Models, Biological; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Cricetinae; Erythropoietin; Humans; Mice; Molecular Weight; Oncogene Proteins; Phosphoproteins; Phosphorylation; Proteins; Receptors, Erythropoietin; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1993 |
Erythropoietin induces the association of phosphatidylinositol 3'-kinase with a tyrosine-phosphorylated protein complex containing the erythropoietin receptor.
Topics: Cell Line; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Growth Substances; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Proteins; Receptors, Erythropoietin; Tyrosine | 1993 |
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Division; Cell Line; Colony-Stimulating Factors; DNA-Binding Proteins; Erythropoietin; Janus Kinase 2; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; ras Proteins; Receptors, Erythropoietin; Shc Signaling Adaptor Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1995 |
Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Enzyme Activation; Erythropoietin; Hematopoiesis; Humans; Megakaryocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Thrombopoietin; Tumor Cells, Cultured; Tyrosine | 1995 |
The signal transduction pathway of erythropoietin involves three forms of mitogen-activated protein (MAP) kinase in UT7 erythroleukemia cells.
Topics: Adaptor Proteins, Signal Transducing; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Membrane; Cyclic AMP; Enzyme Activation; Erythropoietin; GRB2 Adaptor Protein; Humans; Isoenzymes; Kinetics; Leukemia, Erythroblastic, Acute; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells.
Topics: Animals; Base Sequence; Biological Transport; Cell Nucleus; DNA; DNA-Binding Proteins; Erythroid Precursor Cells; Erythropoietin; Kinetics; Mice; Milk Proteins; Molecular Sequence Data; Phosphorylation; STAT1 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine; Vanadates | 1995 |
Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.
Topics: Animals; Cell Division; Cell Line; Erythropoietin; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Mice; Mitosis; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Recombinant Proteins; Tyrosine | 1996 |
Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.
Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; DNA-Binding Proteins; Enzyme Activation; Erythropoietin; Humans; Janus Kinase 2; Milk Proteins; Molecular Sequence Data; Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Erythropoietin; STAT5 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 1996 |
Small peptides as potent mimetics of the protein hormone erythropoietin.
Topics: Amino Acid Sequence; Animals; Bacteriophages; Cell Division; Cell Line; Cloning, Molecular; Erythropoiesis; Erythropoietin; Humans; Ligands; Mice; Molecular Mimicry; Molecular Sequence Data; Mutagenesis; Peptides, Cyclic; Phosphorylation; Protein Structure, Secondary; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; Solubility; Tyrosine | 1996 |
Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Membrane; Chlorocebus aethiops; Cloning, Molecular; Conserved Sequence; Erythropoietin; Escherichia coli; Humans; Kinetics; Ligands; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Protein Structure, Secondary; Receptors, Cytokine; Receptors, Erythropoietin; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection; Tryptophan; Tyrosine | 1996 |
Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA-Binding Proteins; DNA, Complementary; Erythropoietin; Hematopoietic Stem Cells; Mice; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Erythropoietin; STAT5 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 1996 |
Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Cycle Proteins; Erythropoietin; Granulocyte Colony-Stimulating Factor; GRB2 Adaptor Protein; Hematopoietic Stem Cells; Humans; Interleukin-3; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-vav; ras Proteins; Receptors, Cell Surface; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Ubiquitin-Protein Ligases | 1996 |
Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity.
Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; DNA-Binding Proteins; Enzyme Activation; Erythropoietin; Janus Kinase 1; Janus Kinase 3; Mice; Milk Proteins; Molecular Sequence Data; Protein-Tyrosine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-2; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1996 |
Erythropoietin stimulates tyrosine phosphorylation and taurine transport in skate erythrocytes.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Biological Transport; Enzyme Activation; Erythrocytes; Erythropoietin; Genistein; Hydrolysis; Isoenzymes; Isoflavones; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Skates, Fish; Taurine; Type C Phospholipases; Tyrosine | 1996 |
Signal transduction of erythropoietin in endothelial cells.
Topics: Biological Transport, Active; Calcium; Cell Division; Cell Nucleus; Cells, Cultured; Cytosol; DNA-Binding Proteins; Endothelium, Vascular; Erythropoietin; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Milk Proteins; Molecular Weight; Phosphoproteins; Phosphorylation; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1996 |
Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation.
Topics: Animals; Cell Differentiation; Cell Division; DNA Replication; Down-Regulation; Enzyme Activation; Erythropoietin; Genes, myc; Isoenzymes; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 1996 |
Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction.
Topics: DNA-Binding Proteins; Erythropoietin; Glycosylation; Humans; Janus Kinase 2; Milk Proteins; Molecular Weight; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1996 |
Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.
Topics: Animals; Cell Differentiation; Cell Division; Cytoplasm; Dimerization; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Fetus; Gene Expression Regulation; Liver; Mice; Mice, Inbred Strains; Phosphorylation; Proto-Oncogene Proteins c-kit; Receptors, Erythropoietin; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1997 |
Distinct signaling from stem cell factor and erythropoietin in HCD57 cells.
Topics: Apoptosis; Cell Division; Erythropoietin; Leukemia, Erythroblastic, Acute; Phosphorylation; Signal Transduction; Stem Cell Factor; Tumor Cells, Cultured; Tyrosine | 1997 |
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Enzyme Activation; Erythroid Precursor Cells; Erythropoietin; Isoenzymes; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Receptors, Erythropoietin; Tyrosine | 1997 |
A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis.
Topics: Animals; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hemoglobins; Histocytochemistry; Immunoblotting; Janus Kinase 2; Mice; Milk Proteins; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Receptors, Prolactin; Recombinant Fusion Proteins; Signal Transduction; Spleen; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1997 |
A distinct function of STAT proteins in erythropoietin signal transduction.
Topics: Cell Division; Cell Line; Cytokines; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Erythropoietin; Humans; Phosphorylation; Receptors, Erythropoietin; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1997 |
The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation.
Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; DNA-Binding Proteins; Erythropoietin; Inositol Polyphosphate 5-Phosphatases; Milk Proteins; Models, Biological; Mutagenesis, Site-Directed; Phenylalanine; Phosphoric Monoester Hydrolases; Phosphorylation; Receptors, Erythropoietin; Recombinant Proteins; src Homology Domains; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1997 |
Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation.
Topics: Enzyme Activation; Erythropoietin; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Recombinant Proteins; Tumor Cells, Cultured; Tyrosine | 1997 |
Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Erythropoietin; Eukaryotic Initiation Factor-2; Guanine Nucleotide Exchange Factors; Hematopoietic Stem Cells; Humans; Interleukin-3; Intracellular Signaling Peptides and Proteins; Mice; Mutagenesis, Site-Directed; Nuclear Proteins; Phosphorylation; Protein Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-crk; ras Guanine Nucleotide Exchange Factors; Receptors, Erythropoietin; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine; Ubiquitin-Protein Ligases | 1997 |
Establishment and characterization of a new erythropoietin-dependent acute myeloid leukemia cell line, AS-E2.
Topics: Acute Disease; Cell Division; DNA Fingerprinting; Erythropoietin; Humans; Karyotyping; Leukemia, Myeloid; Male; Middle Aged; Neoplasm Proteins; Phosphorylation; Receptors, Erythropoietin; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine | 1997 |
Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo.
Topics: Animals; Cell Line; Erythropoiesis; Erythropoietin; Gene Expression; Gene Transfer Techniques; Mice; Mutagenesis; Phenylalanine; Receptors, Erythropoietin; Recombinant Proteins; Retroviridae; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1998 |
Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; DNA; DNA-Binding Proteins; Enzyme Activation; Erythroid Precursor Cells; Erythropoietin; Female; Humans; Janus Kinase 1; Janus Kinase 2; Mice; Mice, Inbred DBA; Milk Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Recombinant Proteins; Spleen Focus-Forming Viruses; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Viral Envelope Proteins | 1998 |
Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Binding, Competitive; Cell Division; Cell Line; Erythropoietin; Humans; Models, Molecular; Molecular Sequence Data; Peptides, Cyclic; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tyrosine | 1998 |
Erythropoietin receptor-operated Ca2+ channels: activation by phospholipase C-gamma 1.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Enzyme Activation; Erythropoietin; Glomerular Mesangium; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Isoenzymes; Models, Biological; Phospholipase C gamma; Phosphorylation; Rats; Receptors, Erythropoietin; Recombinant Proteins; src-Family Kinases; Type C Phospholipases; Tyrosine | 1998 |
Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors.
Topics: Cells, Cultured; DNA-Binding Proteins; Erythroblasts; Erythropoietin; Humans; Janus Kinase 2; Milk Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 1998 |
Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5.
Topics: Cell Division; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Insulin-Like Growth Factor I; Interleukin-3; Janus Kinase 2; Leukemia, Erythroblastic, Acute; Milk Proteins; Mutation; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; ras Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Stem Cell Factor; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 1998 |
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Topics: Amino Acid Sequence; Animals; Conserved Sequence; Crystallography, X-Ray; Dimerization; DNA-Binding Proteins; Erythropoietin; Humans; Mice; Milk Proteins; Models, Molecular; Molecular Sequence Data; Peptides, Cyclic; Phosphorylation; Protein Conformation; Receptors, Erythropoietin; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tryptophan; Tyrosine | 1998 |
Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; DNA; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Milk Proteins; Nuclear Proteins; Phosphorylation; Protein Binding; STAT5 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 1998 |
Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets.
Topics: Acute-Phase Proteins; Adaptor Proteins, Signal Transducing; Animals; Blood Platelets; Cell Line; Cell Nucleus; DNA; DNA-Binding Proteins; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immune Sera; Interleukin-3; Mice; Milk Proteins; Nuclear Proteins; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Signal Transduction; src Homology Domains; STAT3 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Tyrosine | 1998 |
A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
Topics: Animals; Cell Line; Cell Nucleus; DNA-Binding Proteins; Enzyme Activation; Erythropoietin; Family Health; Humans; Janus Kinase 2; Mice; Milk Proteins; Mutation; Phosphorylation; Polycythemia; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Signal Transduction; STAT5 Transcription Factor; Time Factors; Trans-Activators; Transfection; Tyrosine | 1999 |
APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Line; Cytokines; DNA-Binding Proteins; Erythropoietin; Humans; Janus Kinase 2; Milk Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Trans-Activators; Tyrosine; Ubiquitin-Protein Ligases | 1999 |
Erythropoietin improves signaling through tyrosine phosphorylation in platelets from uremic patients.
Topics: Aged; Blood Platelets; Erythropoietin; Female; Humans; Male; Middle Aged; Phosphorylation; Signal Transduction; Tyrosine; Uremia | 1999 |
Erythropoietin induces glycosylphosphatidylinositol hydrolysis. Possible involvement of phospholipase c-gamma(2).
Topics: Animals; Cell Line; Erythropoietin; Glycosylphosphatidylinositols; Hydrolysis; Isoenzymes; Mutation; Phospholipase C gamma; Phosphorylation; Receptors, Erythropoietin; Transfection; Type C Phospholipases; Tyrosine | 1999 |
The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Enzyme Activation; Erythropoietin; GRB2 Adaptor Protein; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Erythropoietin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 2000 |
Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.
Topics: Enzyme Activation; Erythrocytes; Erythropoietin; Friend murine leukemia virus; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptors, Erythropoietin; Retroviridae Proteins, Oncogenic; Tumor Cells, Cultured; Tyrosine | 2000 |
Proteasomes regulate the duration of erythropoietin receptor activation by controlling down-regulation of cell surface receptors.
Topics: Cell Membrane; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Erythropoietin; Humans; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Receptors, Cell Surface; Receptors, Erythropoietin; Recombinant Proteins; Signal Transduction; Tyrosine | 2000 |
The role of tyrosine 15 in erythropoietin action.
Topics: Antibodies, Monoclonal; Binding Sites; DNA Footprinting; Erythropoietin; Humans; Iodine; Mutagenesis, Site-Directed; Peptide Fragments; Serine Endopeptidases; Trypsin; Tyrosine | 2000 |
Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway.
Topics: Anemia; Animals; Antihypertensive Agents; Apoptosis; Dimerization; Erythropoietin; Humans; Interleukin-1; Janus Kinase 2; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2000 |
Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts.
Topics: Animals; Blotting, Northern; Blotting, Western; Calcium; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; Erythropoietin; GATA1 Transcription Factor; GATA3 Transcription Factor; Humans; Janus Kinase 2; Mice; Mice, Transgenic; Microscopy, Fluorescence; Milk Proteins; Myocardium; MyoD Protein; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Time Factors; Trans-Activators; Transcription Factors; Tyrosine | 2000 |
Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
Topics: Adenosine Triphosphatases; Animals; Biopolymers; Cell Cycle Proteins; Clone Cells; Cysteine Endopeptidases; Erythropoietin; Interleukin-2; Interleukin-9; Mice; Molecular Chaperones; Multienzyme Complexes; Phosphorylation; Polyubiquitin; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Receptors, Cytokine; Receptors, Erythropoietin; Receptors, Interleukin; Receptors, Interleukin-2; Receptors, Interleukin-9; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine; Ubiquitins; Valosin Containing Protein | 2000 |
Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras.
Topics: 3T3 Cells; Amino Acid Motifs; Animals; Blotting, Western; Cell Division; Cell Line; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Erythropoietin; Humans; Interleukin-2; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutation; p120 GTPase Activating Protein; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; ras Proteins; Repressor Proteins; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thymidine; Trans-Activators; Transcription Factors; Transfection; Tyrosine | 2001 |
CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Erythropoietin; Genes, Reporter; Humans; Janus Kinase 2; Mice; Nuclear Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Cross-Talk; Receptors, Erythropoietin; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Deletion; src Homology Domains; src-Family Kinases; Transfection; Tyrosine | 2001 |
Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.
Topics: Cell Division; DNA-Binding Proteins; Enzyme Activation; Erythropoiesis; Erythropoietin; Fusion Proteins, gag-onc; Granulocyte Colony-Stimulating Factor; Humans; Janus Kinase 2; Leukemia; Mutagenesis, Site-Directed; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Receptors, Erythropoietin; Receptors, Granulocyte Colony-Stimulating Factor; Recombinant Fusion Proteins; STAT1 Transcription Factor; STAT3 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Erythropoietin; Humans; Janus Kinase 2; Luciferases; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Recombinant Proteins; Serine; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Stem Cells; Time Factors; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 2002 |
[Proliferative signal transmission mediated by EpoR in leukemic cell lines].
Topics: Cell Division; Dimerization; DNA-Binding Proteins; Erythropoietin; Humans; Janus Kinase 2; Leukemia; Milk Proteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Cell Division; Cell Line; Cells, Cultured; Erythroblasts; Erythropoietin; Friend murine leukemia virus; GRB2 Adaptor Protein; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine; Viral Envelope Proteins | 2002 |
Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Differentiation; Cell Division; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Erythroid Precursor Cells; Erythropoietin; Glycosylphosphatidylinositols; Helminth Proteins; Humans; Hydrolysis; Isoenzymes; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein Binding; Protein Transport; Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Subcellular Fractions; Transfection; Type C Phospholipases; Tyrosine | 2002 |
Mutations in the VHL gene in sporadic apparently congenital polycythemia.
Topics: Adolescent; Adult; Arginine; Aspartic Acid; Base Sequence; Child; Child, Preschool; DNA Mutational Analysis; Erythroid Precursor Cells; Erythropoietin; Female; Heterozygote; Homozygote; Humans; Leucine; Ligases; Male; Mutation; Pedigree; Polycythemia; Sequence Analysis, DNA; Tryptophan; Tumor Suppressor Proteins; Tyrosine; Ubiquitin-Protein Ligases; Valine; Von Hippel-Lindau Tumor Suppressor Protein | 2003 |
Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Carrier Proteins; Cell Differentiation; Erythropoietin; Macrophage Colony-Stimulating Factor; Membrane Glycoproteins; Mice; Osteoclasts; Point Mutation; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Erythropoietin; Recombinant Fusion Proteins; Structure-Activity Relationship; Transfection; Tyrosine | 2002 |
Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling.
Topics: Animals; Cell Line; Enzyme Activation; Erythropoietin; Isoenzymes; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Signal Transduction; src-Family Kinases; Type C Phospholipases; Tyrosine | 2003 |
Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.
Topics: Animals; Binding Sites; Cell Division; Cell Line; Cell Separation; Cytokines; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Epidermal Growth Factor; Erythropoietin; Flow Cytometry; Hematopoietic Stem Cells; Mice; Milk Proteins; Models, Genetic; Mutation; Phosphotyrosine; Proto-Oncogene Proteins c-kit; Receptors, Erythropoietin; Retroviridae; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling.
Topics: Animals; Cell Line; Down-Regulation; Erythropoietin; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptors, Erythropoietin; Signal Transduction; Transfection; Tyrosine | 2004 |
Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities.
Topics: Animals; Biomimetic Materials; Blood Cell Count; Busulfan; Cell Differentiation; Cell Division; Cell Line, Tumor; Colony-Forming Units Assay; DNA-Binding Proteins; Erythropoietin; Humans; Interleukin-11; Janus Kinase 2; Male; Mice; Mice, Inbred BALB C; Milk Proteins; Oxadiazoles; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Thiophenes; Thrombopoiesis; Thrombopoietin; Trans-Activators; Tyrosine | 2004 |
Erythropoietin-dependent autocrine secretion of tumor necrosis factor-alpha in hematopoietic cells modulates proliferation via MAP kinase--ERK-1/2 and does not require tyrosine docking sites in the EPO receptor.
Topics: Animals; Antigens, CD; Autocrine Communication; Binding Sites; Cell Division; Cell Line; Erythropoietin; Hematopoiesis; Hematopoietic Stem Cells; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Receptors, Erythropoietin; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Erythropoietin reduces the development of experimental inflammatory bowel disease.
Topics: Animals; Benzenesulfonates; Colitis; Erythropoietin; Immunohistochemistry; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1; Intestinal Mucosa; Male; Mice; Neutrophil Infiltration; Peroxidase; Poly Adenosine Diphosphate Ribose; Recombinant Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
The critical role of SRC homology domain 2-containing tyrosine phosphatase-1 in recombinant human erythropoietin hyporesponsive anemia in chronic hemodialysis patients.
Topics: Anemia; Antigens, CD34; Blotting, Western; Cell Division; Culture Media; DNA-Binding Proteins; Erythroid Precursor Cells; Erythropoietin; Genetic Vectors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Kidney Failure, Chronic; Milk Proteins; Oligodeoxyribonucleotides, Antisense; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Renal Dialysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Stem Cell Factor; Trans-Activators; Transfection; Tyrosine | 2004 |
Physical and functional interactions between STAP-2/BKS and STAT5.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; COS Cells; Cytoplasm; DNA-Binding Proteins; Erythropoietin; Fluorescent Antibody Technique, Indirect; Glutathione Transferase; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Interleukin-2; Interleukin-3; Mice; Mice, Knockout; Milk Proteins; Phosphoproteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; STAT5 Transcription Factor; Thymus Gland; Time Factors; Trans-Activators; Transcriptional Activation; Transfection; Tumor Suppressor Proteins; Tyrosine | 2005 |
[Granulocyte-macrophage colony-stimulating factor and erythropoietin induce tyrosine phosphorylation and activation of JAK2].
Topics: Cell Line, Tumor; Enzyme Activation; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Janus Kinase 2; Phosphorylation; Tyrosine | 1997 |
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Blood Proteins; Blotting, Western; Cell Cycle; Cell Differentiation; Cell Separation; Crosses, Genetic; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Flow Cytometry; Green Fluorescent Proteins; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Liver; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Receptors, Erythropoietin; Retroviridae; Signal Transduction; Spleen; src Homology Domains; STAT5 Transcription Factor; Stem Cells; Time Factors; Trans-Activators; Tyrosine | 2005 |
Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse.
Topics: Animals; Apoptosis; Arthritis, Experimental; Cartilage, Articular; Chemokines; Chondrocytes; Cytokines; Disease Models, Animal; Erythropoietin; Hematinics; Injections, Subcutaneous; Mice; Mice, Inbred DBA; Neutrophil Infiltration; Poly(ADP-ribose) Polymerases; Tyrosine | 2005 |
Identification of an acquired JAK2 mutation in polycythemia vera.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cytokines; DNA Mutational Analysis; DNA, Complementary; Erythropoietin; HeLa Cells; Heterozygote; Humans; Immunoblotting; Janus Kinase 2; Molecular Sequence Data; Mutation; Phenylalanine; Point Mutation; Polycythemia Vera; Polymerase Chain Reaction; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Signal Transduction; Transfection; Tyrosine; Valine | 2005 |
Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.
Topics: Animals; Cell Line; Cell Proliferation; Cytoplasm; DNA-Binding Proteins; Erythropoietin; Humans; Janus Kinase 2; Mice; Milk Proteins; Mutation; Phosphorylation; Polycythemia; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; STAT1 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2005 |
Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma.
Topics: Biopsy; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Erythropoietin; Gene Expression Regulation; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Immunoprecipitation; Janus Kinase 2; Laminin; Models, Statistical; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Proto-Oncogene Proteins; Receptors, Erythropoietin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrosine | 2005 |
JAK2 in myeloproliferative disorders is not just another kinase.
Topics: Alleles; Animals; Bone Marrow Cells; Cell Lineage; Cell Proliferation; Cytoplasm; DNA; DNA Mutational Analysis; Erythrocytes; Erythropoietin; Homozygote; Humans; Janus Kinase 2; Mice; Mutation; Myelodysplastic Syndromes; Myeloproliferative Disorders; Phenotype; Phosphorylation; Phosphotransferases; Point Mutation; Polycythemia; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Sequence Analysis, DNA; T-Lymphocytes; Tyrosine; Up-Regulation | 2005 |
Erythropoietin receptor spliced forms differentially expressed in blind subterranean mole rats.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Bone Marrow; Cloning, Molecular; DNA, Complementary; Erythropoietin; Gene Expression Regulation; Hypoxia; Mole Rats; Molecular Sequence Data; Oxygen; Phosphorylation; Plasmids; Rats; Receptors, Erythropoietin; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity; Spleen; Tyrosine | 2005 |
Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Cells, Cultured; CSK Tyrosine-Protein Kinase; DNA Mutational Analysis; Enzyme Activation; Erythropoietin; Exons; Gene Deletion; Humans; Ligands; Luciferases; Macrophages; MAP Kinase Signaling System; Mice; Models, Genetic; Molecular Sequence Data; Mutagenesis; NIH 3T3 Cells; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Signal Transduction; Species Specificity; src-Family Kinases; Stem Cells; Transfection; Tyrosine | 2005 |
Resistance to friend virus-induced erythroleukemia in W/W(v) mice is caused by a spleen-specific defect which results in a severe reduction in target cells and a lack of Sf-Stk expression.
Topics: Animals; Erythropoietin; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Mice; Receptor Protein-Tyrosine Kinases; Spleen; Tyrosine | 2005 |
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Cells, Cultured; Dose-Response Relationship, Drug; Drug Carriers; Erythropoietin; Female; Ganglia, Spinal; Glycerol; Humans; Injections, Intraperitoneal; Mice; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Recombinant Proteins; Tubulin; Tyrosine | 2006 |
Effect of ischemic acute renal damage on the expression of COX-2 and oxidative stress-related elements in rat kidney.
Topics: Acute Kidney Injury; Animals; Cyclooxygenase 2; Erythropoietin; Heme Oxygenase-1; Ischemia; Kidney; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Renin; Tissue Distribution; Tyrosine | 2007 |
TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells.
Topics: Antigens, CD34; Calcium; Calcium Channels; Cell Differentiation; Cell Membrane; Erythrocytes; Erythropoietin; Estrenes; Humans; Inositol 1,4,5-Trisphosphate Receptors; Microscopy, Video; Models, Biological; Pyrrolidinones; TRPC Cation Channels; Type C Phospholipases; Tyrosine | 2008 |
Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex.
Topics: Binding Sites; Cell Proliferation; Cells, Cultured; Computer Simulation; Erythropoietin; Humans; Janus Kinase 2; Models, Molecular; Mutation; Protein Conformation; Receptors, Erythropoietin; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Tyrosine | 2009 |
Erythropoietin attenuates lung injury in lipopolysaccharide treated rats.
Topics: Animals; Erythropoietin; Lipopolysaccharides; Lung; Lung Injury; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Calcium as a mediator between erythropoietin and protein tyrosine phosphatase 1B.
Topics: Calcium; Calpain; Cell Differentiation; Cell Line; Cell Proliferation; Erythropoietin; Humans; Intracellular Space; Isoenzymes; Molecular Weight; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RNA, Messenger; TRPC Cation Channels; TRPC6 Cation Channel; Tyrosine | 2011 |
Amniotic fluid oxidative and nitrosative stress biomarkers correlate with fetal chronic hypoxia in diabetic pregnancies.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Amniocentesis; Amniotic Fluid; Biomarkers; Birth Weight; Chromatography, High Pressure Liquid; Chronic Disease; Deoxyguanosine; Diabetes Mellitus, Type 1; Diabetes, Gestational; Erythropoietin; Female; Fetal Hypoxia; Gestational Age; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Immunoassay; Infant, Newborn; Insulin; Male; Nitrosation; Oxidative Stress; Pilot Projects; Pregnancy; Pregnancy in Diabetics; Tandem Mass Spectrometry; Tyrosine; Young Adult | 2013 |
Incorporation of ortho- and meta-tyrosine into cellular proteins leads to erythropoietin-resistance in an erythroid cell line.
Topics: Cell Line; Cell Proliferation; Drug Resistance; Epoetin Alfa; Erythroid Cells; Erythropoietin; Humans; MAP Kinase Signaling System; Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Tyrosine | 2013 |
Activity increase in EpoR and Epo expression by intranasal recombinant human erythropoietin (rhEpo) administration in ischemic hippocampi of adult rats.
Topics: Administration, Intranasal; Animals; Brain Ischemia; Cell Survival; Cytoprotection; Erythropoietin; Hippocampus; Humans; Male; Neuroprotective Agents; Phosphorylation; Rats, Wistar; Receptors, Erythropoietin; Recombinant Proteins; Tyrosine | 2014 |
Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats.
Topics: Animals; Blood Pressure; Body Weight; Creatinine; Disease Models, Animal; Endothelium, Vascular; Erythropoietin; Femoral Artery; Heart Rate; Hemoglobins; Kidney Function Tests; Male; NADPH Oxidase 4; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type III; Nitroglycerin; Polyethylene Glycols; Proteinuria; Rats; Renal Insufficiency, Chronic; Tyrosine; Ultrasonography; Vasodilation | 2015 |
Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction.
Topics: Cell-Penetrating Peptides; Click Chemistry; Erythropoietin; Fluorides; HeLa Cells; Humans; Microscopy, Confocal; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfur Compounds; Tyrosine | 2018 |
EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27
Topics: Animals; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Erythropoietin; Mice; Phosphorylation; Receptors, Erythropoietin; Signal Transduction; Tyrosine | 2023 |