Compounds > tyrosine

tyrosine and kn 62

tyrosine has been researched along with kn 62 in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T1
Baraldi, PG; Di Virgilio, F; Falzoni, S; Makaeva, R; Moro, S; Nuñez, Mdel C; Pavani, MG; Romagnoli, R; Spalluto, G1
Baraldi, PG; del Carmen Nuñez, M; Di Virgilio, F; Falzoni, S; Morelli, A; Romagnoli, R1
Baraldi, PG; Borea, PA; Cara, CL; Carrion, MD; Cruz-Lopez, O; Fogli, E; Gessi, S; Moorman, AR; Preti, D; Romagnoli, R; Sacchetto, V; Tabrizi, MA1

Other Studies

4 other study(ies) available for tyrosine and kn 62

ArticleYear
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
    The Journal of biological chemistry, 1994, Jul-01, Volume: 269, Issue:26

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine

1994
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
    Arzneimittel-Forschung, 2002, Volume: 52, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Membrane Permeability; Cells, Cultured; Humans; Indicators and Reagents; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Monocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Spectrophotometry, Infrared; Structure-Activity Relationship; Tetrahydroisoquinolines; Tyrosine

2002
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Arylsulfonates; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ethidium; Humans; Interleukin-1; Macrophages; Monocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Structure-Activity Relationship; Tyrosine

2003
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; beta-Alanine; Calcium; Cell Line; Cell Membrane; Cell Membrane Permeability; Ethidium; Fluorescent Dyes; Glycine; Humans; Isoquinolines; Naphthalenes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfones; Tyrosine

2007