tyrosine and imatinib mesylate

tyrosine has been researched along with imatinib mesylate in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	40 (71.43)	29.6817
2010's	12 (21.43)	24.3611
2020's	4 (7.14)	2.80

Authors

Authors	Studies
Frasca, F; Vella, V; Vigneri, P; Vigneri, R; Wang, JY	1
Arlinghaus, RB; Liu, J; Smithgall, TE; Sun, T; Wang, Y; Wilson, MB; Xie, S	1
Gesbert, F; Griffin, JD; Gu, H; Iwasaki, H; Li, S; Malouf, NA; Mohi, MG; Neel, BG; Podar, K; Pride, YB; Quinnan, LR; Sattler, M; Van Etten, RA	1
Brasher, BB; Gorre, ME; Nicoll, J; Roumiantsev, S; Sawyers, CL; Shah, NP; Van Etten, RA	1
Hochhaus, A; Lahaye, T; Müller, MC	1
Brill, LM; Brinker, A; Brock, A; Ericson, C; Ficarro, SB; Horn, DM; Peters, EC; Phung, QT; Salomon, AR; Sauer, K; Schultz, PG	1
Breitenbuecher, F; Carius, B; Fischer, T; Gschaidmeier, H; Huber, C; Kasper, S; Kindler, T; Stevens, T	1
Feng, G; Finn, AJ; Pendergast, AM	1
Briesewitz, R; Bruner, RJ; Caligiuri, MA; Griffin, JH; Leung, J	1
Akiyama, S; Aoki, S; Che, XF; Furukawa, T; Haraguchi, M; Kobayashi, M; Mukai, M; Ren, XQ; Sugimoto, Y; Sumizawa, T; Takamatsu, H	1
Frisa, PS; Goolsby, CL; Gottlieb, MA; Hedley, DW; Jacobberger, JW; Paniagua, M; Shankey, TV; Smith, BL; Sramkoski, RM; Ye, PP	1
Bohr, VA; Cheng, WH; Fields, KM; Kufe, D; Opresko, PL; Ren, J; von Kobbe, C	1
Ishida, S; Kamijo, T; Kinoshita, T; Koike, K; Komiyama, A; Kurokawa, Y; Matsuzawa, S; Nakajima, M; Nakazawa, Y; Sakashita, K; Shiohara, M; Takeuchi, K; Yamashita, T	1
Bai, RY; Duyster, J; Grundler, R; Hoepfl, J; Miething, C; Mugler, C; Peschel, C	1
Miller, WT; Yokoyama, N	1
Alizadeh, AA; Botstein, D; Brown, PO; Diehn, M; Lin, J; Roose, JP; Tomlinson, MG; Weiss, A	1
Bhat, A; Deininger, MW; Druker, BJ; Gaston, I; Johnson, KJ; Langdon, W; Oda, T; Reis, M; Shen, L	1
Ain, KB; Dziba, JM	1
Egorin, MJ; Ilaria, RL; Minna, JD; Randle, DE; Wolff, NC	1
All-Ericsson, C; Brodin, B; Girnita, L; Larsson, O; Müller-Brunotte, A; Ostman, A; Seregard, S	1
Babendreier, E; Chauhan, D; Chu, SC; Gramlich, JL; Griffin, JD; Kim, JH; Podar, K; Pride, YB; Salgia, R; Sattler, M	1
Anderson, K; Atadja, P; Catley, L; Cavazza, C; Fuerst, P; Griffin, JD; Kujawa, J; Remiszewski, S; Weisberg, E	1
Cheng, D; McLaughlin, J; Shokat, KM; Witte, ON; Wong, S; Zhang, C	1
Ba, X; Chen, C; Gao, Y; Zeng, X	1
Cowan-Jacob, SW; Fabbro, D; Fendrich, G; Jahnke, W; Liebetanz, J; Manley, PW; Meyer, T	1
Cortes, JE; Donato, NJ; Gao, H; Kantarjian, HM; Lee, BN; Reuben, JM; Talpaz, M	1
Kim, S; Kim, Y; Lee, D; Oh, C; Park, J; Yoon, SS	1
Frischknecht, F; Newsome, TP; Way, M; Weisswange, I	1
Abe, T; Ishigami, H; Kameda, H; Suzuki, M; Takeuchi, T	1
Basic, I; Chandra, J; Giles, F; Golemovic, M; Kantarjian, H; Manshouri, T; Orsolic, N; Quintás-Cardama, A; Scappini, B; Verstovsek, S	1
Clarkson, B; Hajivandi, M; Liang, X; Pope, RM; Resh, MD; Veach, D; Wisniewski, D	1
Catley, L; Fabbro, D; Griffin, JD; Hall-Meyers, E; Jiang, J; Kung, AL; Manley, PW; Moreno, D; Podar, K; Ray, A; Weisberg, E; Wright, RD	1
Benati, D; Bustos, VH; Coluccia, AM; Duñach, M; Gambacorti-Passerini, C; Mologni, L; Pinna, LA; Redaelli, S; Vacca, A	1
Arlinghaus, R; Deng, W; Ji, L; Lin, J; Minna, J; Roth, J; Sun, T	1
Akin, C; Hungness, SI	1
Bhatia, R; Chu, S; Li, L; Singh, H	1
Kajiguchi, T; Lee, MJ; Lee, S; Neckers, L; Trepel, JB	1
Adamovich, Y; Levy, D; Reuven, N; Shaul, Y	1
Bumm, T; Deininger, MW; Druker, BJ; Hantschel, O; Kaupe, I; Press, RD; Sherbenou, DW; Superti-Furga, G; Turaga, L; Willis, S	1
Aitken, RJ; Baker, MA; Curry, B; Hetherington, L	1
Bornmann, WG; Daniels, L; Donato, NJ; Meng, F; Peng, Z; Peterson, LF; Quintás-Cardama, A; Roulston, D; Talpaz, M; Wu, J; Ying, Y	1
Burg, MB; Ferraris, JD; Gallazzini, M; Gunaratne, R; Yu, MJ	1
Ali, SF; Bains, M; Clark, RA; Imam, SZ; Kahle, PJ; Li, S; Roberts, JL; Valente, AJ; Yamamoto, A; Zhou, Q	1
Inada, M; Ishida-Kitagawa, N; Kuwano, M; Maruoka, M; Matsui, A; Ogawa, T; Sato, M; Takeya, T; Yokota, N	1
Preyer, M; Vigneri, P; Wang, JY	1
Anderson, KI; Bleijerveld, OB; Corradini, E; Heck, AJ; Kolch, W; Müller, PJ; Preisinger, C; Scholten, A; Schwarz, JP	1
Ako, M; Doki, Y; Fujimoto, M; Ikezoe, T; Kurokawa, Y; Miyata, H; Miyazaki, Y; Mori, M; Naka, T; Nakajima, K; Nakatsuka, R; Nishida, T; Serada, S; Shimada, K; Taguchi, T; Takahashi, T; Takiguchi, S; Yamasaki, M; Yokoyama, A	1
Amin, HM; Granda, JG; Shi, B; Shi, P; Vishwamitra, D; Whitton, T	1
Bu, Q; Cui, L; Ding, K; Du, X; Li, J; Pan, J; Zou, W	1
Bálint, Z; Dahal, BK; Kwapiszewska, G; Murmann, K; Schermuly, RT; Seeger, W; Veith, C; Weissmann, N; Wygrecka, M; Zakrzewicz, D	1
Goff, SP; Wang, GZ	1
Alexander, KE; Daraiseh, SI; Hurt, MM; Kassardjian, A; Rizkallah, R	1
Cao, YJ; Rao, GW; Xu, XL; Zhang, W	1
Choithramani, A; Das, R; Shard, A	1
Doytchinova, I; Iwanov, I; Momekov, G; Montesi, M; Naydenova, E; Panseri, S; Rossi, A; Sargsyan, A	1
Cao, J; Chen, F; Chen, Y; Feng, XH; Gao, C; Gu, S; Li, X; Liang, T; Lin, X; Liu, X; Qin, J; Tong, H; Wang, L; Xu, P; Yu, Y; Yuan, S; Zhao, B	1

Reviews

3 review(s) available for tyrosine and imatinib mesylate

Article	Year
Mastocytosis: advances in diagnosis and treatment. Current allergy and asthma reports, 2007, Volume: 7, Issue:4 Topics: Amino Acid Substitution; Benzamides; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Mast Cells; Mastocytosis; Mutation, Missense; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine	2007
Research Status, Synthesis and Clinical Application of Recently Marketed and Clinical BCR-ABL Inhibitors. Current medicinal chemistry, 2022, Volume: 29, Issue:17 Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Protein Kinase Inhibitors; Tyrosine	2022
A molecular perspective for the use of type IV tyrosine kinase inhibitors as anticancer therapeutics. Drug discovery today, 2022, Volume: 27, Issue:3 Topics: Imatinib Mesylate; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Tyrosine	2022

Other Studies

53 other study(ies) available for tyrosine and imatinib mesylate

Article	Year
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor. Oncogene, 2001, Jun-28, Volume: 20, Issue:29 Topics: Antineoplastic Agents; Benzamides; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Hepatocyte Growth Factor; Humans; Imatinib Mesylate; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morphogenesis; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyrimidines; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrosine	2001
Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation. Oncogene, 2001, Sep-27, Volume: 20, Issue:43 Topics: Animals; Benzamides; Blotting, Western; COS Cells; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Fusion Proteins, bcr-abl; Gene Deletion; Glutathione Transferase; Humans; Imatinib Mesylate; Janus Kinase 2; K562 Cells; Mice; Mice, Nude; Milk Proteins; Mutation; Phosphorylation; Piperazines; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; STAT5 Transcription Factor; Time Factors; Trans-Activators; Transfection; Tyrosine	2001
Critical role for Gab2 in transformation by BCR/ABL. Cancer cell, 2002, Volume: 1, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Benzamides; Cell Division; Cell Movement; Cell Transformation, Neoplastic; Erythroid Precursor Cells; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Guanosine Triphosphate; Helminth Proteins; Humans; Imatinib Mesylate; Immunoblotting; Leukemia, Lymphoid; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Precipitin Tests; Proteins; Pyrimidines; Signal Transduction; Tyrosine	2002
Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proceedings of the National Academy of Sciences of the United States of America, 2002, Aug-06, Volume: 99, Issue:16 Topics: Antineoplastic Agents; Benzamides; Drug Resistance; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phenylalanine; Phosphorylation; Piperazines; Point Mutation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Pyrimidines; Tyrosine	2002
[Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells]. Deutsche medizinische Wochenschrift (1946), 2002, Oct-18, Volume: 127, Issue:42 Topics: Amino Acid Substitution; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clone Cells; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Histidine; Humans; Hydroxyurea; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mercaptopurine; Middle Aged; Oncogene Proteins, Fusion; Piperazines; Point Mutation; Pyrimidines; Selection, Genetic; Tyrosine	2002
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America, 2003, Jan-21, Volume: 100, Issue:2 Topics: Amino Acid Sequence; Benzamides; Chromatography, High Pressure Liquid; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Jurkat Cells; Mass Spectrometry; Molecular Sequence Data; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Tyrosine; ZAP-70 Protein-Tyrosine Kinase	2003
In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C. Leukemia, 2003, Volume: 17, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Caspases; Cell Division; Cytarabine; DNA; DNA-Binding Proteins; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; In Situ Nick-End Labeling; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Phosphorylation; Piperazines; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein-Tyrosine Kinases; Pyrimidines; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine; U937 Cells	2003
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nature neuroscience, 2003, Volume: 6, Issue:7 Topics: Adaptor Proteins, Signal Transducing; Agrin; Animals; Animals, Newborn; Autonomic Denervation; Benzamides; Blotting, Western; Brain; Bungarotoxins; Cell Aggregation; Cells, Cultured; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Homeodomain Proteins; Imatinib Mesylate; Immunohistochemistry; In Vitro Techniques; Mice; Muscle Denervation; Muscles; Myoblasts; Neurofilament Proteins; Neuromuscular Junction; Phosphorylation; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Pyrimidines; Rabbits; Radioimmunoassay; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Synapses; Synaptophysin; Time Factors; Transfection; Tyrosine	2003
Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proceedings of the National Academy of Sciences of the United States of America, 2003, Jun-24, Volume: 100, Issue:13 Topics: Adult; Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Benzamides; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Gene Deletion; Humans; Hypereosinophilic Syndrome; Imatinib Mesylate; Indoles; Male; Mice; Models, Chemical; Models, Genetic; Molecular Sequence Data; Peptides; Phthalazines; Piperazines; Precipitin Tests; Protein Structure, Tertiary; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Recombinant Fusion Proteins; Recurrence; Tyrosine	2003
Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells. Cancer science, 2003, Volume: 94, Issue:6 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Membrane; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; KB Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukotrienes; Multidrug Resistance-Associated Proteins; Phosphorylation; Photoaffinity Labels; Piperazines; Pyrimidines; Tyrosine	2003
Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2003, Volume: 54, Issue:2 Topics: Antibodies, Monoclonal; Benzamides; Blotting, Western; Cell Line; Cell Line, Tumor; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Epitopes; Flow Cytometry; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Immunoblotting; Indoles; Inhibitory Concentration 50; Interleukin-2; Interleukin-4; K562 Cells; Kinetics; Methanol; Microscopy, Fluorescence; Milk Proteins; Phosphorylation; Piperazines; Protein Binding; Pyrimidines; Signal Transduction; Spectrometry, Fluorescence; STAT5 Transcription Factor; Time Factors; Trans-Activators; Tumor Suppressor Proteins; Tyrosine	2003
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Molecular and cellular biology, 2003, Volume: 23, Issue:18 Topics: Animals; Benzamides; Binding Sites; Bleomycin; DNA Damage; DNA Helicases; Enzyme Inhibitors; Exodeoxyribonucleases; HeLa Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Phosphorylation; Piperazines; Protein Transport; Proto-Oncogene Proteins c-abl; Pyrimidines; Recombinant Proteins; RecQ Helicases; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Werner Syndrome Helicase	2003
STI571 inhibits growth and adhesion of human mast cells in culture. Journal of leukocyte biology, 2003, Volume: 74, Issue:6 Topics: Antigens, CD; Apoptosis; Benzamides; Cell Adhesion; Cell Division; Cells, Cultured; Drug Combinations; Enzyme Inhibitors; Female; Fetal Blood; Fibronectins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imatinib Mesylate; Infant, Newborn; Mast Cells; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine	2003
Phosphorylation of tyrosine 393 in the kinase domain of Bcr-Abl influences the sensitivity towards imatinib in vivo. Leukemia, 2003, Volume: 17, Issue:9 Topics: Antineoplastic Agents; Benzamides; Cell Division; Cell Line; DNA-Binding Proteins; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Milk Proteins; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Piperazines; Pyrimidines; STAT5 Transcription Factor; Trans-Activators; Transfection; Tyrosine	2003
Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. The Journal of biological chemistry, 2003, Nov-28, Volume: 278, Issue:48 Topics: Animals; Baculoviridae; Benzamides; Blotting, Western; Catalytic Domain; cdc42 GTP-Binding Protein; Cell Line; COS Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genetic Vectors; Imatinib Mesylate; Insecta; Kinetics; Ligands; Mass Spectrometry; Models, Genetic; Peptides; Phosphorylation; Piperazines; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-hck; Pyrimidines; src Homology Domains; Substrate Specificity; Tyrosine	2003
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS biology, 2003, Volume: 1, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; B-Lymphocytes; Benzamides; Blotting, Northern; Blotting, Western; Cell Separation; DNA-Binding Proteins; DNA, Complementary; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gene Expression Regulation; Homeodomain Proteins; Humans; Imatinib Mesylate; Immunoprecipitation; Jurkat Cells; Ligands; MAP Kinase Signaling System; Mice; Models, Biological; Molecular Sequence Data; Multigene Family; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-abl; Pyrimidines; Receptors, Antigen, T-Cell; RNA; Signal Transduction; Thymus Gland; Transcription, Genetic; Tyrosine	2003
Coexistence of phosphotyrosine-dependent and -independent interactions between Cbl and Bcr-Abl. Experimental hematology, 2004, Volume: 32, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Humans; Imatinib Mesylate; Mice; Phosphorylation; Phosphotyrosine; Piperazines; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Pyrimidines; src Homology Domains; Two-Hybrid System Techniques; Tyrosine; Ubiquitin-Protein Ligases	2004
Imatinib mesylate (gleevec; STI571) monotherapy is ineffective in suppressing human anaplastic thyroid carcinoma cell growth in vitro. The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:5 Topics: Antineoplastic Agents; Benzamides; Carcinoma; Cell Cycle; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression; Genes, abl; Humans; Imatinib Mesylate; Oncogene Proteins; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Thyroid Neoplasms; Tyrosine	2004
Imatinib mesylate efficiently achieves therapeutic intratumor concentrations in vivo but has limited activity in a xenograft model of small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, May-15, Volume: 10, Issue:10 Topics: Animals; Antineoplastic Agents; Benzamides; Brain Neoplasms; Carcinoma, Small Cell; Cell Line, Tumor; Humans; Imatinib Mesylate; Immunoblotting; Immunoprecipitation; Ligands; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; NIH 3T3 Cells; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Signal Transduction; Stem Cell Factor; Time Factors; Tyrosine	2004
c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target? Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Benzamides; Blotting, Western; Cell Division; Female; Humans; Imatinib Mesylate; Immunoenzyme Techniques; Male; Melanoma; Middle Aged; Paraffin Embedding; Phosphorylation; Piperazines; Polymerase Chain Reaction; Proto-Oncogene Mas; Proto-Oncogene Proteins c-kit; Pyrimidines; RNA, Messenger; Skin Neoplasms; Tumor Cells, Cultured; Tyrosine; Uveal Neoplasms	2004
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood, 2005, Feb-15, Volume: 105, Issue:4 Topics: Benzamides; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Deoxyglucose; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Jurkat Cells; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monosaccharide Transport Proteins; Phloretin; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinases; Pyrimidines; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Tyrosine; Up-Regulation	2005
Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo. Leukemia, 2004, Volume: 18, Issue:12 Topics: Acetylation; Acute Disease; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Bone Marrow Cells; Cell Cycle; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Female; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Imatinib Mesylate; In Vitro Techniques; Leukemia, Myeloid; Mice; Mice, Inbred BALB C; Phosphorylation; Piperazines; Pyrimidines; Tumor Cells, Cultured; Tyrosine	2004
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of America, 2004, Dec-14, Volume: 101, Issue:50 Topics: Apoptosis; B-Lymphocytes; Benzamides; Cell Cycle; Cell Line; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Enzymologic; Humans; Imatinib Mesylate; Mutation; Myeloproliferative Disorders; Phosphotyrosine; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine	2004
Signaling function of PSGL-1 in neutrophil: tyrosine-phosphorylation-dependent and c-Abl-involved alteration in the F-actin-based cytoskeleton. Journal of cellular biochemistry, 2005, Feb-01, Volume: 94, Issue:2 Topics: Actins; Antibodies, Monoclonal; Antineoplastic Agents; Benzamides; Cross-Linking Reagents; Cytoskeleton; Genistein; Humans; Imatinib Mesylate; Membrane Glycoproteins; Neutrophils; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; Signal Transduction; Tyrosine	2005
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation. Structure (London, England : 1993), 2005, Volume: 13, Issue:6 Topics: Amino Acid Sequence; Benzamides; Binding Sites; Conserved Sequence; Crystallography, X-Ray; Enzyme Activation; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imatinib Mesylate; Inhibitory Concentration 50; Leucine; Models, Chemical; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Myristic Acid; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Piperazines; Protein Binding; Proto-Oncogene Proteins c-abl; Pyrimidines; Sequence Homology, Amino Acid; src Homology Domains; src-Family Kinases; Tyrosine	2005
Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia. Leukemia, 2005, Volume: 19, Issue:11 Topics: Antineoplastic Agents; Benzamides; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Culture Techniques; Cell Proliferation; Cytokines; Enterotoxins; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocyte Activation; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Tyrosine; ZAP-70 Protein-Tyrosine Kinase	2005
Differential tyrosine phosphorylation of leukemic cells during apoptosis as a result of treatment with imatinib mesylate. Biochemical and biophysical research communications, 2005, Oct-28, Volume: 336, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Electrophoresis, Gel, Two-Dimensional; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteome; Pyrimidines; Transcription, Genetic; Tyrosine	2005
Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cellular microbiology, 2006, Volume: 8, Issue:2 Topics: Actins; Animals; Benzamides; Biological Transport, Active; Cell Line; Humans; Imatinib Mesylate; Phosphorylation; Piperazines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Pyrimidines; Signal Transduction; src-Family Kinases; Tyrosine; Vaccinia virus; Viral Structural Proteins	2006
Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor. Clinical and experimental immunology, 2006, Volume: 144, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Arthritis; Arthritis, Rheumatoid; Benzamides; Cell Division; Cells, Cultured; Fibroblasts; Humans; Imatinib Mesylate; Osteoarthritis; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Synovial Membrane; Tyrosine	2006
Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer science, 2006, Volume: 97, Issue:9 Topics: Adamantane; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Humans; Hydroquinones; Imatinib Mesylate; Inhibitory Concentration 50; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Phosphorylation; Piperazines; Pyrimidines; Tyrosine	2006
Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells. Proteomics, 2006, Volume: 6, Issue:16 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Isotope Labeling; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Oncogene Protein v-cbl; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Pyrimidines; Tyrosine	2006
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity. Gastroenterology, 2006, Volume: 131, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Imatinib Mesylate; Male; Mice; Mice, Nude; Phosphorylation; Piperazines; Point Mutation; Protein Kinase Inhibitors; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; Staurosporine; Tyrosine; Xenograft Model Antitumor Assays	2006
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. The EMBO journal, 2007, Mar-07, Volume: 26, Issue:5 Topics: Apoptosis; Benzamides; beta Catenin; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Fusion Proteins, bcr-abl; Glycogen Synthase Kinase 3; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Models, Biological; Phosphorylation; Piperazines; Protein Binding; Protein-Tyrosine Kinases; Pyrimidines; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; Tyrosine	2007
Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. Oncogene, 2007, Oct-25, Volume: 26, Issue:49 Topics: Animals; Benzamides; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Death; Cells, Cultured; Chlorocebus aethiops; Colony-Forming Units Assay; COS Cells; Enzyme Activation; Fibroblasts; Humans; Imatinib Mesylate; Immunoprecipitation; In Situ Nick-End Labeling; Lung Neoplasms; Peptide Fragments; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; Tumor Suppressor Proteins; Tyrosine	2007
BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia. Cancer research, 2007, Jul-15, Volume: 67, Issue:14 Topics: Antigens, CD34; Benzamides; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Fusion Proteins, bcr-abl; Green Fluorescent Proteins; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcr; Pyrimidines; ras Proteins; Retroviridae; Tyrosine	2007
KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia. Leukemia research, 2008, Volume: 32, Issue:5 Topics: Active Transport, Cell Nucleus; Benzamides; beta Catenin; Humans; Imatinib Mesylate; Leukemia, Mast-Cell; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyrimidines; Signal Transduction; Tyrosine	2008
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Molecular cell, 2008, Feb-15, Volume: 29, Issue:3 Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Benzamides; Cell Line; Cell Line, Tumor; Cisplatin; Cycloheximide; DNA Damage; DNA-Binding Proteins; Gamma Rays; Half-Life; HCT116 Cells; HeLa Cells; Humans; Imatinib Mesylate; Kidney; Kinetics; Nuclear Proteins; Phosphoproteins; Phosphorylation; Piperazines; Plasmids; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; RNA, Messenger; Transcription Factors; Transfection; Tumor Protein p73; Tumor Suppressor Proteins; Tyrosine; YAP-Signaling Proteins	2008
Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia. Leukemia, 2008, Volume: 22, Issue:6 Topics: Adult; Aged; Benzamides; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoblotting; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Phosphorylation; Piperazines; Precursor Cells, B-Lymphoid; Protein Conformation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Sequence Deletion; Tyrosine	2008
Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation. Developmental biology, 2009, Sep-01, Volume: 333, Issue:1 Topics: Animals; Benzamides; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Flagella; Imatinib Mesylate; Male; Mice; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-abl; Pyrimidines; Sperm Capacitation; Spermatozoa; Threonine; Tyrosine	2009
ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells. Leukemia, 2010, Volume: 24, Issue:4 Topics: Animals; Antineoplastic Agents; Benzamides; Benzene Derivatives; Cells, Cultured; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Interleukin-3; K562 Cells; Mice; Mutation; Phosphorylation; Piperazines; Precursor Cells, B-Lymphoid; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles; Tyrosine	2010
c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:11 Topics: Amino Acid Sequence; Animals; Benzamides; Cell Line; Enzyme Activation; HEK293 Cells; HeLa Cells; Humans; Imatinib Mesylate; Kidney Medulla; Male; Molecular Sequence Data; NFATC Transcription Factors; Phosphorylation; Piperazines; Protein Transport; Proto-Oncogene Proteins c-abl; Pyrimidines; Rats; Rats, Sprague-Dawley; Sequence Alignment; Sodium Chloride; Transcriptional Activation; Tyrosine	2010
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jan-05, Volume: 31, Issue:1 Topics: Acetylcysteine; Animals; Benzamides; Brain; Case-Control Studies; Cell Line; Disease Models, Animal; Dopamine; Drug Administration Schedule; Free Radical Scavengers; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Imatinib Mesylate; Immunoprecipitation; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; MPTP Poisoning; Oxidative Stress; Peptide Elongation Factors; Phosphorylation; Piperazines; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; RNA, Small Interfering; Statistics, Nonparametric; Transfection; Tumor Suppressor Proteins; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination	2011
Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1. FEBS letters, 2011, Mar-23, Volume: 585, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Binding Sites; Blotting, Western; Cell Adhesion; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytoskeletal Proteins; Fibronectins; HEK293 Cells; Humans; Imatinib Mesylate; K562 Cells; Microfilament Proteins; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; src Homology Domains; Tandem Mass Spectrometry; Tyrosine	2011
Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL. PloS one, 2011, Feb-11, Volume: 6, Issue:2 Topics: Actins; Active Transport, Cell Nucleus; Animals; Benzamides; Cell Nucleus; Chlorocebus aethiops; COS Cells; Cytoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Models, Molecular; Mutagenesis; Mutation; Nuclear Localization Signals; Phosphorylation; Piperazines; Protein Folding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrimidines; Tyrosine	2011
Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells. Leukemia, 2013, Volume: 27, Issue:3 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Benzamides; Blast Crisis; Cell Membrane; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoprecipitation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Phosphotyrosine; Piperazines; Pyrimidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tyrosine	2013
New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis. International journal of cancer, 2013, Dec-01, Volume: 133, Issue:11 Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Focal Adhesion Protein-Tyrosine Kinases; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Phosphoproteins; Phosphorylation; Phosphotransferases; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Tyrosine	2013
Molecular and functional characterizations of the association and interactions between nucleophosmin-anaplastic lymphoma kinase and type I insulin-like growth factor receptor. Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:6 Topics: Animals; Benzamides; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Imatinib Mesylate; Lymphoma, T-Cell; Mice; Mutation; NIH 3T3 Cells; Phospholipase C gamma; Phosphorylation; Piperazines; Protein Stability; Protein-Tyrosine Kinases; Pyrimidines; Receptor, IGF Type 1; Receptor, Platelet-Derived Growth Factor beta; Tyrosine	2013
SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells. Cancer biology & therapy, 2014, Volume: 15, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydroxamic Acids; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Tyrosine; Vorinostat	2014
Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment. Thrombosis and haemostasis, 2014, Volume: 112, Issue:6 Topics: Active Transport, Cell Nucleus; Animals; Antihypertensive Agents; Apoptosis; Becaplermin; Benzamides; Cell Adhesion; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imatinib Mesylate; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; RNA Interference; Signal Transduction; Time Factors; Transfection; Tyrosine; Vascular Remodeling	2014
Regulation of Yin Yang 1 by Tyrosine Phosphorylation. The Journal of biological chemistry, 2015, Sep-04, Volume: 290, Issue:36 Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Epidermal Growth Factor; Gene Expression; HEK293 Cells; HeLa Cells; Humans; Imatinib Mesylate; Indoles; Jurkat Cells; Mutation; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; src-Family Kinases; Sulfonamides; Tyrosine; YY1 Transcription Factor	2015
c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity. Biochimica et biophysica acta. Molecular cell research, 2018, Volume: 1865, Issue:9 Topics: Benzamides; Conserved Sequence; Gene Knockout Techniques; Gene Silencing; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Imatinib Mesylate; MCF-7 Cells; Oncogene Proteins v-abl; Phosphorylation; Pyrazoles; Pyrimidines; Transcription, Genetic; Tyrosine; YY1 Transcription Factor	2018
Peptide-based targeted cancer therapeutics: Design, synthesis and biological evaluation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2022, Sep-01, Volume: 176 Topics: Antineoplastic Agents; Glioblastoma; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Peptides; Protein Kinase Inhibitors; Tyrosine	2022
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia. Signal transduction and targeted therapy, 2023, 03-24, Volume: 8, Issue:1 Topics: Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Smad4 Protein; Transforming Growth Factor beta; Tyrosine	2023