tyrosine has been researched along with herbimycin in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.30) | 18.7374 |
| 1990's | 120 (77.92) | 18.2507 |
| 2000's | 29 (18.83) | 29.6817 |
| 2010's | 3 (1.95) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, RT; Karnitz, LM; Leibson, PJ; Schoon, RA; Ting, AT | 1 |
| Green, SP; Hamilton, JA; Phillips, WA | 1 |
| DeFranco, AL; Lemke, K; Pelech, SL; Sanghera, JS; Weinstein, SL | 1 |
| Brown, TJ; Kallestad, JC; Ledbetter, JA; Linsley, PS; Schieven, GL | 1 |
| Fletcher, MC; Freeman, GJ; June, CH; Kamoun, M; Ledbetter, JA; Nadler, LM; Thompson, CB; Turka, LA; Vandenberghe, P | 1 |
| Chatila, T; Geha, RS; Spertini, F | 1 |
| Adachi, T; Hirayama, E; Kim, J; Okada, Y; Yabubayashi, T | 1 |
| Burridge, K; Romer, LH; Turner, CE | 1 |
| Ahern, D; Geha, RS; Scholl, PR | 1 |
| Offermanns, S; Schultz, G | 1 |
| Boone, E; Cohen, DI; Lane, HC; Samelson, LE; Tani, Y; Tian, H | 1 |
| Hamaguchi, M; Matsuyoshi, N; Nagafuchi, A; Takeichi, M; Taniguchi, S; Tsukita, S | 1 |
| Min, HK; Park, DJ; Rhee, SG | 1 |
| Grosmaire, LS; Ledbetter, JA; Schieven, GL; Tsu, TT | 1 |
| Clark, EA; Deans, J; Draves, K; Lane, PJ; Ledbetter, JA; McConnell, FM; Schieven, GL | 1 |
| DeFranco, AL; Gold, MR; Weinstein, SL | 1 |
| Carter, RH; Fearon, DT; Park, DJ; Rhee, SG | 1 |
| Koike, T; Nakashima, S; Nozawa, Y | 1 |
| Abraham, RT; Binstadt, BA; Einspahr, KJ; Leibson, PJ; Uehara, Y | 1 |
| Kawai, S; Mizuno, S; Murakami, Y; Uehara, Y | 1 |
| Mizuno, S; Murakami, Y; Sugimoto, Y; Uehara, Y | 1 |
| Giasson, E; Haddad, P; Leduc, I; Meloche, S | 1 |
| Anafi, M; Ben-Neriah, Y; Gazit, A; Levitzki, A; Zehavi, A | 1 |
| Furuno, T; Ikebuchi, H; Nakanishi, M; Sawada, J; Terao, T; Teshima, R | 1 |
| Goodwyn, D; Itaya, T; Kawamura, K; Miyagishima, T; Miyazaki, T; Okabe, M; Sakurada, K; Shoji, M; Uehara, M; Vogler, WR | 1 |
| Hagmann, W | 1 |
| Doherty, P; Furness, J; Walsh, FS; Williams, EJ | 1 |
| Faris, M; Fu, SM; Gaskin, F; Parsons, JT | 1 |
| Hall, CL; Lange, LA; Turley, EA; Wang, C | 1 |
| Hattori, S; Katagiri, K; Katagiri, T; Nakamura, S; Yamamoto, T; Yoshida, T | 1 |
| Eguchi, K; Kawabe, Y; Migita, K; Mizokami, A; Nagataki, S; Tsukada, T | 1 |
| Abboud, HE; Biswas, P; Choudhury, GG; Grandaliano, G | 1 |
| Chan, AS; Reynolds, PJ; Shimizu, Y | 1 |
| Hitoshi, Y; Katagiri, T; Kikuchi, Y; Kitamura, D; Sato, S; Takaki, S; Takatsu, K; Tsukada, S; Watanabe, T; Witte, O; Yonehara, S | 1 |
| Anderson, MT; Gitler, C; Herzenberg, LA; Staal, FJ | 1 |
| Kramer, RH; Matsumoto, K; Nakamura, T | 1 |
| Claesson, MH; Odum, N; Skov, S | 1 |
| Doki, Y; Inoue, M; Iwazawa, T; Kadowaki, T; Matsui, S; Oka, H; Shimaya, K; Shiozaki, H; Takeichi, M; Tamura, S | 1 |
| Devenish, RJ; Grubb, D; Hatzinisiriou, I; Linnane, AW; Payne, MJ; Ralph, SJ; Wines, BD | 1 |
| Mahon, TM; O'Neill, LA | 1 |
| Arcangeli, A; Bartolini, P; Bianchi, L; Mugnai, G; Olivotto, M; Wanke, E | 1 |
| Adachi, K; Asano, H; Hamaguchi, M; Ito, T; Koizumi, KT; Murate, T; Saga, S; Saito, H; Watanabe, T; Yoshida, S | 1 |
| Bolen, JB; Haskill, S; Juliano, RL; Lin, TH; Mondal, K; Rosales, C | 1 |
| Hirabayashi, Y; Ji, L; Zhang, G | 1 |
| Cheung, PY; Dackiw, AP; Fingerote, R; Levy, GA; Nathens, AB; Rotstein, OD; Zakrzewski, K | 1 |
| Nishiya, T; Nomura, Y; Uehara, T | 1 |
| Fujiwara, T; Hamada, S; Kaya, H; Kimura, S; Koga, T; Kontani, M; Shintoku, K | 1 |
| Arditi, M; Durden, DL; Kim, KS; Stins, M; Torres, M; Zhou, J | 1 |
| Furuya, Y; Mashima, K | 1 |
| Hasuma, T; Matsui-Yuasa, I; Min, A; Otani, S; Yano, Y | 1 |
| Ahn, JS; Ahn, SC; Kim, BY; Lee, HS; Mheen, TI; Oh, HK; Rho, HM | 1 |
| DuMaine, J; Morrison, AR; Rzymkiewicz, DM | 1 |
| Koide, Y; Ryu, K; Yamashita, Y; Yoshida, TO | 1 |
| Fujio, Y; Shibata, N; Takahashi, K; Yamada, F | 1 |
| de Jonge, HR; Edixhoven, MJ; Tertoolen, LG; Tilly, BC; van den Berghe, N | 1 |
| DeFranco, AL; June, CH; Weinstein, SL | 1 |
| Gordon, J; Knox, KA | 1 |
| Aruffo, A; Clark, EA; Deans, JP; Gilliland, LA; Ledbetter, JA; Schieven, GL; Shu, GL; Valentine, MA | 1 |
| Cunningham, DD; Grabham, P | 1 |
| Kruse, HJ; Negrescu, EV; Siess, W; Weber, PC | 1 |
| Haskill, S; Juliano, RL; Kornberg, L; Lin, TH; Morris, J; Walker, JJ; Yurochko, A | 1 |
| Hamaguchi, M; Iwamoto, T; Katano, Y; Kato, M; Nakashima, I; Ohkusu, K; Pu, MY; Rahman, SM; Yoshida, T; Zhang, YH | 1 |
| Connelly, PA; Farrell, CA; Richard, S; Shaw, AS; Showell, HJ | 1 |
| Hayashi, Y; Hino, K; Honma, Y; Hozumi, M; Matsuo, Y; Omura, S; Sato, S; Shibata, K; Tomoyasu, S; Tsuruoka, N | 1 |
| Dearden-Badet, MT; Revillard, JP | 1 |
| Gilliland, LK; Kirihara, JM; Ledbetter, JA; Schieven, GL; Uckun, FM | 1 |
| Ali, S; Becker, MW; Davis, MG; Dorn, GW | 1 |
| Gotoh, B; Hamaguchi, M; Matsuyoshi, N; Nagai, Y; Ohnishi, Y; Takeichi, M | 1 |
| Bankhurst, AD; Doshi, RN; Homma, Y; Whalen, MM | 1 |
| Honma, Y; Hozumi, M; Kanatani, Y; Kasukabe, T; Motoyoshi, K; Nagata, N | 1 |
| Kiener, PA; Mittler, RS; Rankin, BM; Yocum, SA | 1 |
| Liao, F; Rhee, SG; Shin, HS | 1 |
| Kanner, SB; Ledbetter, JA; Odum, N; Svejgaard, A | 1 |
| Holt, C; Worley, T | 1 |
| Ahn, JS; Ahn, SC; Kang, DO; Kim, BY; Ko, HR; Lee, HS; Mheen, TI; Oh, WK; Rho, HM | 1 |
| Cavallini, D; Duprè, S; Fontana, M; Kodama, H; Sagara, Y; Zhang, J | 1 |
| Agrawal, DK; Chisholm, LJ; Edwards, JD; Pearson, TJ | 1 |
| Hosoe, S; Kijima, T; Kishimoto, T; Kumagai, T; Mori, M; Osaki, T; Sakuma, T; Tachibana, I; Tanio, Y; Ueno, K | 1 |
| Bolen, J; Jin, J; Jun, X; Tuel-Ahlgren, L; Uckun, FM; Waddick, KG | 1 |
| Genco, RJ; Saito, A; Sojar, HT | 1 |
| Dawson, AP; Lane, K; Vande Woude, GF; Warn, RM; Webb, CP | 1 |
| Hamaguchi, M; Hayakawa, T; Iwata, H; Koike, T; Noguchi, T; Shinagawa, A; Suzuki, M; Yamashita, K | 1 |
| Nakano, H; Pillay, I; Sharma, SV | 1 |
| Cirone, M; Faggioni, A; Frati, L; Tarasi, D; Zompetta, C | 1 |
| Huber, M; Kandolf, R; Selinka, HC | 1 |
| Colamonici, OR; Krolewski, JJ; Platanias, LC; Sweet, M; Uddin, S | 1 |
| Ganapathy, V; Kekuda, R; Leibach, FH; Prasad, PD; Torres-Zamorano, V | 1 |
| Hirayama, E; Isobe, A; Kim, J; Nishioka, M; Okamoto, H | 1 |
| Hagar, H; Shah, SV; Ueda, N | 1 |
| Rikihisa, Y; Zhang, Y | 1 |
| Couture, C; Gauthier, N; Mustelin, T; Tailor, P; Williams, S | 1 |
| Bloom, ET; Domae, N; Huang, JY; Kono, T; Okazaki, T; Tabassam, FH; Umehara, H | 1 |
| Brenner, B; Grassmé, H; Gulbins, E; Koppenhoefer, U; Lang, F; Lepple-Wienhues, A; Müller, C; Speer, CP | 1 |
| Birukov, KG; Birukova, AA; Lehoux, S; Merval, R; Tedgui, A; Tkachuk, VA | 1 |
| Ido, M; Ito, Y; Kawano, M; Komada, H; Nishio, M; Ohgimoto, S; Okamoto, K; Sakurai, M; Suga, S; Tabata, N; Tsurudome, M; Watanabe, N | 1 |
| Kasahara, T; Sonoda, Y; Ueno, M; Watanabe, S; Yokota-Aizu, E | 1 |
| Kanters, D; Koenderman, L; Lammers, JW; Raaijmakers, JA; Tool, AT; van der Bruggen, T; Verhoeven, AJ | 1 |
| Cambon, C; Caput, D; Ferrara, P; Hasan, L; Pipy, B; Séguélas, MH; Sozzani, P | 1 |
| Hinshaw, DB; Nguyen, PK; Omann, GM; Sweeney, JF | 1 |
| Eguchi, K; Kawabe, Y; Migita, K; Nagataki, S; Tsukada, T | 1 |
| Attali, B; Peretz, A; Sobko, A | 1 |
| DeVries, ME; Feldman, RD; Kelvin, DJ; Khandaker, MH; Mitchell, G; Pickering, JG; Rahimpour, R; Singhal, SK; Xu, L | 1 |
| DeWitt, DL; Shankavaram, UT; Wahl, LM | 1 |
| Hioki, K; Masuya, Y; Taketani, S; Tokunaga, R | 1 |
| Eisen, AZ; Li, L; Seltzer, JL; Sturman, E | 1 |
| Exton, JH; Kim, EG; Min, DS | 1 |
| Fukazawa, H; Mizuno, S; Murakami, Y; Uehara, Y | 1 |
| Ott, VL; Rapraeger, AC | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Chu, CL; Orlow, DL; Reenstra, WR; Svoboda, KK | 1 |
| Kwiatkowska, K; Sobota, A | 1 |
| Feldman, RD; Kelvin, DJ; Khandaker, MH; Lazarovits, AI; Madrenas, J; Mitchell, GB; Pickering, JG; Pomerantz, DK; Rahimpour, R; Suria, H; Xu, L | 1 |
| Haier, J; Nasralla, M; Nicolson, GL | 1 |
| Alvarez, J; Barrero, MJ; Hernández, M; Montero, M; Nieto, ML; Sánchez Crespo, M | 1 |
| Adachi, R; Kasahara, T; Matsui, S; Nagaishi, K; Suzuki, K; Yamaguchi, T | 1 |
| Barry-Lane, PA; Cavanagh, HD; Huang, J; Jester, JV; Kao, WW; Petroll, WM | 1 |
| Berk, BC; Kawakatsu, H; Murry, CE; Okuda, M; Suero, J; Takahashi, M; Traub, O | 1 |
| Peerschke, EI | 1 |
| El-Shazly, A; Ishikawa, T; Masuyama, K; Suda, T; Yamaguchi, N | 1 |
| Carbajal, JM; Cohen, AW; Schaeffer, RC | 1 |
| Dierich, MP; Speth, C; Zhu, X | 1 |
| Miyakoshi, J; Yagi, K | 1 |
| Davis, FB; Davis, PJ; Lin, HY; Tsan, MF; White, JE | 1 |
| Strayer, DS; White, MK | 1 |
| Griffith, R; Soria, J; Wood, JG | 1 |
| Nakamura, M; Tanigawa, Y | 1 |
| Jow, F; Wang, K | 1 |
| Katow, H; Washio, M | 1 |
| Bertics, PJ; Chun, TY; Gorski, J; Kim, YN; Watters, JJ | 1 |
| da Costa, SR; Hamm-Alvarez, SF; Schönthal, AH; Vilalta, PM; Wang, Y | 1 |
| Fujioka, T; Ishibashi, K; Ui, M | 1 |
| Ali, S; Deng, H; Dong, K; Giebisch, G; Gu, R; Hebert, SC; Huang, XY; Moral, Z; Sterling, H; Wang, WH; Wei, Y | 1 |
| Al-Okla, S; Chatenay-Rivauday, C; Klein, JP; Wachsmann, D | 1 |
| Boland, R; de Boland, AR; Gentili, C | 1 |
| Hamada, M; Kosaka, N; Nakano, H; Oneyama, C; Sharma, SV; Sugawara, K; Tamaoki, T; Yamashita, Y | 1 |
| Cartel, NJ; Liu, J; Post, M; Wang, J | 1 |
| Jaso-Friedmann, L; Leary, JH; Ruiz, J | 1 |
| Hasuma, T; Kennedy, DO; Kojima, A; Koshimizu, K; Matsui-Yuasa, I; Moffatt, J; Murakami, A; Ohigashi, H; Otani, S; Yano, Y | 1 |
| Cayabyab, FS; Schlichter, LC | 1 |
| Fuhrer, C; Marangi, PA; Wieland, ST | 1 |
| Fan, YP; Puri, RN; Rattan, S | 1 |
| Idell, S; Shetty, S | 1 |
| Luxon, BA; Milliano, MT | 1 |
| Furuyama, S; Matsuda-Honjyo, Y; Nakao, S; Ogata, Y; Shimizu, E; Sugiya, H; Yamazaki, M | 1 |
| Chai, JK; Chen, ML; Song, HF; Wu, YQ | 1 |
| Alrefai, WA; Dudeja, PK; Gill, RK; Ramaswamy, K; Saksena, S; Sarwar, Z; Tyagi, S | 1 |
| Hudry-Clergeon, H; Ninio, E; Stengel, D; Vilgrain, I | 1 |
| Drobot, L; Husak, Z; Igumentseva, N; Ilnytska, O; Kusen', S; Oleksyn, H | 1 |
| Ariyama, H; Baba, E; Harada, M; Kusaba, H; Nakano, S; Qin, B; Tanaka, R | 1 |
| Grevelding, CG; Knobloch, J; Kunz, W | 1 |
| Alpern, RJ; Huang, HC; Preisig, PA; Yang, X; Yin, H | 1 |
| Kasai, S; Kikuchi, H | 1 |
| Hashizume, H; Kamio, N; Matsushima, K; Muromachi, K; Nakao, S; Narita, T | 1 |
| Fujii, H; Kusama, T; Okamoto, H | 1 |
154 other study(ies) available for tyrosine and herbimycin
| Article | Year |
|---|---|
Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells.
Topics: Antibody-Dependent Cell Cytotoxicity; Benzoquinones; Cell Line; Enzyme Activation; Humans; Immunoblotting; Isoenzymes; Killer Cells, Natural; Kinetics; Lactams, Macrocyclic; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, IgG; Rifabutin; Type C Phospholipases; Tyrosine | 1992 |
Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents.
Topics: Animals; Benzoquinones; Bone Marrow Cells; Cells, Cultured; Cinnamates; Enzyme Activation; In Vitro Techniques; Interferon-gamma; Lactams, Macrocyclic; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred CBA; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Respiratory Burst; Rifabutin; Sulfides; Tumor Necrosis Factor-alpha; Tyrosine; Vanadates; Zymosan | 1992 |
Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.
Topics: Amino Acid Sequence; Animals; Benzoquinones; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Isoenzymes; Lactams, Macrocyclic; Lipopolysaccharides; Macrophages; Mice; Molecular Sequence Data; Peptides; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Quinones; Rifabutin; Tyrosine | 1992 |
Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase.
Topics: Benzoquinones; Cells, Cultured; Cytokines; Endothelium, Vascular; Enzyme Activation; Genistein; Humans; Interleukin-6; Isoflavones; Lactams, Macrocyclic; Oncostatin M; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-yes; Quinones; Receptors, Cell Surface; Receptors, Cytokine; Receptors, Oncostatin M; Rifabutin; src-Family Kinases; Tyrosine | 1992 |
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; CD28 Antigens; Histocompatibility Antigens; Humans; In Vitro Techniques; Interleukin-2; Lactams, Macrocyclic; Leukocyte Common Antigens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Quinones; Receptor Aggregation; Receptors, Cell Surface; Rifabutin; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; Calcium; CD3 Complex; Cytokines; Gene Expression; Histocompatibility Antigens; HLA-D Antigens; Humans; In Vitro Techniques; Inositol Phosphates; Lactams, Macrocyclic; Leukocyte Common Antigens; Lymphocyte Activation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptor Aggregation; Receptors, Antigen, T-Cell; Rifabutin; RNA, Messenger; Second Messenger Systems; Signal Transduction; T-Lymphocytes; Tyrosine | 1992 |
Differentiation of quail myoblasts transformed with a temperature sensitive mutant of Rous sarcoma virus. I. Relationship between differentiation and tyrosine kinase of src gene product.
Topics: Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Differentiation; Cell Fusion; Cell Line, Transformed; Coturnix; Creatine Kinase; Gene Expression; Genes, src; Lactams, Macrocyclic; Muscles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Temperature; Tyrosine | 1992 |
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
Topics: 3T3 Cells; Animals; Benzoquinones; Blotting, Western; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cytoskeletal Proteins; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Lactams, Macrocyclic; Mice; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1992 |
Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; Benzoquinones; Calcium; Humans; Immunoglobulin G; Lactams, Macrocyclic; Leukemia, Myeloid; Monocytes; Phosphorylation; Quinones; Receptors, Fc; Receptors, IgG; Rifabutin; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Type C Phospholipases; Tyrosine | 1992 |
Tyrosine phosphorylation is an early and requisite signal induced by interferon-gamma in HL-60 cells.
Topics: Benzoquinones; Genistein; Interferon-gamma; Isoflavones; Lactams, Macrocyclic; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Fc; Rifabutin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1992 |
Participation of tyrosine phosphorylation in the cytopathic effect of human immunodeficiency virus-1.
Topics: Benzoquinones; CD4 Antigens; Cell Line; Cytopathogenic Effect, Viral; HIV Envelope Protein gp41; HIV-1; Humans; Lactams, Macrocyclic; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, T-Cell; Rifabutin; Signal Transduction; T-Lymphocytes; Transfection; Tyrosine; Viral Envelope Proteins | 1992 |
Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.
Topics: Animals; Benzoquinones; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Line, Transformed; Collagen; Fibroblasts; Fluorescent Antibody Technique; Gels; Immunoblotting; Lactams, Macrocyclic; Neoplasm Metastasis; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Quinones; Rats; Rifabutin; Tyrosine; Vanadates | 1992 |
IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.
Topics: Animals; Benzoquinones; Blotting, Western; Enzyme Activation; Immunoglobulin E; Isoenzymes; Lactams, Macrocyclic; Leukemia, Basophilic, Acute; Phosphorylation; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Quinones; Rats; Rifabutin; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine phosphorylation regulates phospholipase C activation in human T-cells.
Topics: Anti-Bacterial Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; Calcium; CD2 Antigens; CD3 Complex; CD4 Antigens; Cell Membrane; Cells, Cultured; Enzyme Activation; Humans; Lactams, Macrocyclic; Phosphorylation; Quinones; Receptors, Antigen, T-Cell; Receptors, Immunologic; Rifabutin; Signal Transduction; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1991 |
The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.
Topics: Aluminum; Aluminum Compounds; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Calcium; CD40 Antigens; Cell Line; Cross-Linking Reagents; Fluorides; Genistein; Humans; Immunoglobulin M; Isoflavones; Lactams, Macrocyclic; Models, Biological; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, B-Cell; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1991 |
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.
Topics: Animals; Benzoquinones; Cell Line, Transformed; Escherichia coli; Female; Kinetics; Lactams, Macrocyclic; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Salmonella; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.
Topics: Aluminum; Aluminum Compounds; Animals; B-Lymphocytes; Benzoquinones; Cell Line; Cell Membrane; Enzyme Activation; Fluorides; Immunoglobulin M; Inositol Phosphates; Kinetics; Lactams, Macrocyclic; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, B-Cell; Rifabutin; Type C Phospholipases; Tyrosine | 1991 |
Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses.
Topics: Anti-Bacterial Agents; Benzoquinones; Blood Platelets; Cinnamates; Genistein; Humans; Isoflavones; Lactams, Macrocyclic; Phospholipids; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serotonin; Signal Transduction; Sulfides; Thromboxane A2; Tyrosine | 1991 |
Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.
Topics: Antibiotics, Antineoplastic; Antigens, CD; Benzoquinones; Cell Line; Cells, Cultured; Clone Cells; Cytotoxicity, Immunologic; Humans; Killer Cells, Natural; Lactams, Macrocyclic; Lymphocyte Activation; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Fc; Rifabutin; Signal Transduction; Tyrosine | 1991 |
Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A.
Topics: Animals; Arvicolinae; Benzoquinones; Cell Line; Cell Transformation, Viral; Chick Embryo; Fibroblasts; Lactams, Macrocyclic; Mice; Oncogene Proteins, Viral; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1988 |
Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.
Topics: Amino Acids; Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Line; Cell Transformation, Neoplastic; Herbicides; Kinetics; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Retroviridae Proteins; Rifabutin; Thermodynamics; Tyrosine | 1989 |
Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genistein; Isoflavones; Lactams, Macrocyclic; Male; Muscle Proteins; Muscle, Smooth, Vascular; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Inbred BN; Receptors, Angiotensin; Rifabutin; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transcriptional Activation; Type C Phospholipases; Tyrosine | 1995 |
Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.
Topics: 3T3 Cells; Animals; Benzoquinones; Catechols; Cell Differentiation; Cell Division; Cell Line; ErbB Receptors; Fusion Proteins, bcr-abl; Humans; Kinetics; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Platelet-Derived Growth Factor; Rifabutin; Time Factors; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1993 |
Effects of herbimycin A and ST638 on Fc epsilon receptor-mediated histamine release and Ca2+ signals in rat basophilic leukemia (RBL-2H3) cells.
Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Calcium; Cell Line; Cinnamates; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fura-2; Histamine Release; Inositol 1,4,5-Trisphosphate; Kinetics; Lactams, Macrocyclic; Leukemia, Basophilic, Acute; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Receptors, IgG; Rifabutin; Sulfides; Tumor Cells, Cultured; Tyrosine | 1994 |
Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Fusion Proteins, bcr-abl; Genistein; Humans; Isoflavones; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line.
Topics: Animals; Benzoquinones; Catechols; Cell Division; Cell Line; Genistein; Interleukin-3; Interleukin-4; Ionomycin; Isoflavones; Kinetics; Lactams, Macrocyclic; Leukemia, Basophilic, Acute; Leukotrienes; Mast-Cell Sarcoma; Mice; Nitriles; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1994 |
Neurite outgrowth stimulated by the tyrosine kinase inhibitor herbimycin A requires activation of tyrosine kinases and protein kinase C.
Topics: Animals; Benzoquinones; Calcium; Cerebellum; Enzyme Activation; Lactams, Macrocyclic; Nerve Tissue Proteins; Neurites; Neurons; Phenols; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Tyrosine | 1994 |
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Burkitt Lymphoma; CD40 Antigens; Cell Line; Cell Line, Transformed; Enzyme Precursors; Genistein; Herpesvirus 4, Human; Humans; Intracellular Signaling Peptides and Proteins; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Palatine Tonsil; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Sulfonamides; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1994 |
Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity.
Topics: Antibodies; Benzoquinones; Carrier Proteins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Cell Movement; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Hyaluronan Receptors; Hyaluronic Acid; Isoflavones; Lactams, Macrocyclic; Microinjections; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptor, Insulin; Receptors, Cell Surface; Receptors, Lymphocyte Homing; Rifabutin; Signal Transduction; Tyrosine; Vinculin | 1994 |
Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.
Topics: Benzoquinones; Cell Differentiation; Dexamethasone; Enzyme Activation; Granulocytes; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Monocytes; Mutation; Oncogene Protein p21(ras); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinones; ras GTPase-Activating Proteins; Rifabutin; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1994 |
Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.
Topics: Animals; Apoptosis; Benzoquinones; CD3 Complex; Clonal Deletion; Dexamethasone; Genistein; Isoflavones; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; T-Lymphocyte Subsets; Thymus Gland; Tyrosine | 1994 |
Mitogenic signaling of thrombin in mesangial cells: role of tyrosine phosphorylation.
Topics: Benzoquinones; Calcium; Cells, Cultured; Cysteine; DNA; Gene Expression; Genistein; Glomerular Mesangium; Humans; Immunoblotting; Inositol Phosphates; Isoflavones; Lactams, Macrocyclic; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Sulfur Radioisotopes; Thrombin; Tyrosine | 1994 |
Tyrosine kinase activity associated with the CD7 antigen: correlation with regulation of T cell integrin function.
Topics: Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; Cell Adhesion; Fibronectins; Humans; Integrins; Intercellular Adhesion Molecule-1; Lactams, Macrocyclic; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Quinones; Rifabutin; T-Lymphocytes; Tyrosine; Up-Regulation | 1994 |
IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Antibodies, Monoclonal; B-Lymphocytes; Benzoquinones; Cell Line; Cricetinae; Enzyme Activation; Humans; Interleukin-5; Janus Kinase 1; Janus Kinase 2; Kinetics; Lactams, Macrocyclic; Lymphocyte Activation; Macromolecular Substances; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinones; Receptors, Interleukin; Receptors, Interleukin-5; Rifabutin; Transfection; Tyrosine | 1994 |
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
Topics: Benzoquinones; Cell Line; Gene Expression; Gene Rearrangement, T-Lymphocyte; Humans; In Vitro Techniques; Lactams, Macrocyclic; NF-kappa B; Oxidation-Reduction; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.
Topics: Benzoquinones; Carcinoma, Squamous Cell; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hepatocyte Growth Factor; Humans; In Vitro Techniques; Integrins; Lactams, Macrocyclic; Mouth Neoplasms; Neoplasm Invasiveness; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
MHC class I signaling in T cells leads to tyrosine kinase activity and PLC-gamma 1 phosphorylation.
Topics: Benzoquinones; Calcium; Histocompatibility Antigens Class I; Humans; Isoenzymes; Lactams, Macrocyclic; Leukocyte Common Antigens; Phospholipase C gamma; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Quinones; Receptor-CD3 Complex, Antigen, T-Cell; Rifabutin; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1995 |
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Topics: alpha Catenin; Benzoquinones; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Aggregation; Cell Line; Culture Techniques; Cytoskeletal Proteins; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Fibroblasts; Fluorescent Antibody Technique; Gels; Humans; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine; Vanadates | 1995 |
Resistance of melanoma cell lines to interferons correlates with reduction of IFN-induced tyrosine phosphorylation. Induction of the anti-viral state by IFN is prevented by tyrosine kinase inhibitors.
Topics: 2',5'-Oligoadenylate Synthetase; Antiviral Agents; Benzoquinones; Drug Resistance; Genistein; GTP-Binding Proteins; Humans; Interferons; Isoflavones; Lactams, Macrocyclic; Melanoma; Myxovirus Resistance Proteins; Neoplasm Proteins; Phosphorylation; Protein Biosynthesis; Protein-Tyrosine Kinases; Quinones; Rifabutin; Semliki forest virus; Tumor Cells, Cultured; Tyrosine | 1995 |
Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A.
Topics: Animals; Benzoquinones; Cell Line; Dithiothreitol; Interleukin-1; Lactams, Macrocyclic; Mercaptoethanol; Mice; NF-kappa B; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
An inward rectifier K+ current modulates in neuroblastoma cells the tyrosine phosphorylation of the pp125FAK and associated proteins: role in neuritogenesis.
Topics: Animals; Benzoquinones; Cell Adhesion Molecules; Cell Line; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Lactams, Macrocyclic; Membrane Potentials; Mice; Neoplasm Proteins; Neurites; Neuroblastoma; Patch-Clamp Techniques; Phosphoproteins; Phosphorylation; Phosphotyrosine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein-Tyrosine Kinases; Quinones; Receptor, Insulin; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1995 |
Herbimycin A inhibits phorbol ester-induced morphologic changes, adhesion, and megakaryocytic differentiation of the leukemia cell line, MEG-01.
Topics: Benzoquinones; Cell Adhesion; Cell Differentiation; Genes, fos; Genes, jun; Humans; Lactams, Macrocyclic; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Naphthalenes; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase.
Topics: Benzoquinones; Cell Adhesion; Cell Adhesion Molecules; Enzyme Activation; Enzyme Precursors; Extracellular Matrix Proteins; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genistein; Humans; Inflammation; Integrin beta1; Integrins; Interleukin-1; Intracellular Signaling Peptides and Proteins; Isoflavones; Lactams, Macrocyclic; Leukemia, Monocytic, Acute; Monocytes; NF-kappa B; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1995 |
Inhibition of tumor necrosis factor alpha- and ceramide-induced internucleosomal DNA fragmentation by herbimycin A in U937 cells.
Topics: Apoptosis; Benzoquinones; Ceramides; DNA; Humans; Lactams, Macrocyclic; Nucleosomes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Second Messenger Systems; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.
Topics: Animals; Benzoquinones; Catechols; Cells, Cultured; Female; Genistein; Hepatitis, Viral, Animal; Isoflavones; Kinetics; Lactams, Macrocyclic; Macrophages, Peritoneal; Mice; Murine hepatitis virus; Nitriles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine; Tyrphostins | 1995 |
Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells.
Topics: Animals; Base Sequence; Benzoquinones; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glioma; Interferon-gamma; Janus Kinase 2; Lactams, Macrocyclic; Lipopolysaccharides; Molecular Sequence Data; NF-kappa B; Nitric Oxide Synthase; Oligodeoxyribonucleotides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinones; Rats; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine protein phosphorylation in murine B lymphocytes by stimulation with lipopolysaccharide from Porphyromonas gingivalis.
Topics: Animals; B-Lymphocytes; Benzoquinones; Cell Membrane; Cytosol; Escherichia coli; Lactams, Macrocyclic; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphorylation; Porphyromonas gingivalis; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Tyrosine | 1995 |
Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44, p42, and p41 in vascular endothelial cells in a soluble CD14-dependent manner. Role of protein tyrosine phosphorylation in lipopolysaccharide-induced stim
Topics: Amino Acid Sequence; Animals; Benzoquinones; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Child; Child, Preschool; Dose-Response Relationship, Immunologic; Endothelium, Vascular; Humans; Lactams, Macrocyclic; Lipopolysaccharide Receptors; Lipopolysaccharides; Mice; Microcirculation; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1995 |
Adhesion-inducible DNA synthesis regulated by tyrosine phosphorylation/dephosphorylation.
Topics: Animals; Benzoquinones; Cell Adhesion; Cell Line; DNA; Enzyme Inhibitors; Epithelium; Fibronectins; Lactams, Macrocyclic; Liver; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; Signal Transduction; Tyrosine; Vanadates | 1995 |
Regulation of apoptosis of interleukin 2-dependent mouse T-cell line by protein tyrosine phosphorylation and polyamines.
Topics: Animals; Apoptosis; Benzoquinones; Cell Division; Cell Line; Chromatin; DNA; Enzyme Inhibitors; Interleukin-2; Lactams, Macrocyclic; Mice; Ornithine Decarboxylase; Phosphorylation; Polyamines; Propidium; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; T-Lymphocytes; Tyrosine; Vanadates | 1995 |
Inhibition of PDGF-induced phospholipase D but not phospholipase C activation by herbimycin A.
Topics: 3T3 Cells; Animals; Benzoquinones; Enzyme Activation; Lactams, Macrocyclic; Mice; Phospholipase D; Phosphorylation; Platelet-Derived Growth Factor; Quinones; Receptors, Platelet-Derived Growth Factor; Rifabutin; Signal Transduction; Type C Phospholipases; Tyrosine | 1995 |
IL-1 beta regulates rat mesangial cyclooxygenase II gene expression by tyrosine phosphorylation.
Topics: Animals; Benzoquinones; Cells, Cultured; Dinoprostone; Gene Expression Regulation, Enzymologic; Genistein; Glomerular Mesangium; Interleukin-1; Isoflavones; Lactams, Macrocyclic; Male; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Tyrosine; Vanadates | 1995 |
Inhibition of tyrosine phosphorylation prevents IFN-gamma-induced HLA-DR molecule expression.
Topics: Benzoquinones; Calcimycin; Calcium; Genistein; HLA-DR Antigens; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Interferon-gamma; Isoflavones; Lactams, Macrocyclic; Nitriles; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1993 |
Responses of smooth muscle cells to platelet-derived growth factor are inhibited by herbimycin-A tyrosine kinase inhibitor.
Topics: Actins; Animals; Benzoquinones; Cell Division; Cell Line; Dose-Response Relationship, Drug; Kinetics; Lactams, Macrocyclic; Muscle, Smooth, Vascular; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Pulmonary Artery; Quinones; Rats; Rifabutin; Tyrosine | 1993 |
Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.
Topics: Benzoquinones; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Genistein; Humans; Hypotonic Solutions; Intestines; Iodides; Isoflavones; Kinetics; Lactams, Macrocyclic; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Quinones; Rifabutin; Rubidium; Tyrosine; Vanadates; Water-Electrolyte Balance | 1993 |
Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzoquinones; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Lactams, Macrocyclic; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Phosphorylation; Proteins; Quinones; Rifabutin; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Apoptosis; B-Lymphocytes; Benzoquinones; Calcium; CD40 Antigens; Cross-Linking Reagents; Egtazic Acid; Humans; In Vitro Techniques; Lactams, Macrocyclic; Phosphatidylinositols; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Tyrosine | 1993 |
Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2.
Topics: Antigens, CD; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Cells, Cultured; Enzyme Activation; Genes, myc; Humans; Immunoglobulin M; Lactams, Macrocyclic; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, B-Cell; Rifabutin; Type C Phospholipases; Tyrosine | 1993 |
Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation.
Topics: Animals; Astrocytes; Benzoquinones; Cell Division; Lactams, Macrocyclic; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rats; Receptors, Thrombin; Rifabutin; Thrombin; Tyrosine | 1995 |
Thrombin-induced Ca2+ influx and protein tyrosine phosphorylation in endothelial cells is inhibited by herbimycin A.
Topics: Benzoquinones; Calcium; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Ion Transport; Lactams, Macrocyclic; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Thrombin; Tyrosine | 1994 |
The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes.
Topics: Benzoquinones; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Genes, Immediate-Early; Genistein; Humans; Integrins; Interleukin-1; Isoflavones; Lactams, Macrocyclic; Monocytes; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Transcriptional Activation; Tyrosine | 1994 |
Pathway of signal delivery to murine thymocytes triggered by co-crosslinking CD3 and Thy-1 for cellular DNA fragmentation and growth inhibition.
Topics: Animals; Antigens, Surface; Benzoquinones; CD3 Complex; Cells, Cultured; DNA; Genes, fos; Lactams, Macrocyclic; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; T-Lymphocytes; Thy-1 Antigens; Transcription, Genetic; Tyrosine | 1993 |
C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil.
Topics: Benzoquinones; Cell Line; Chemotactic Factors; Complement C5a; Humans; In Vitro Techniques; Interleukin-8; Lactams, Macrocyclic; Leukotriene B4; Models, Biological; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Quinones; Receptor, Anaphylatoxin C5a; Receptors, Complement; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.
Topics: Antibiotics, Antineoplastic; Benzoquinones; Cell Differentiation; Cell Division; Fusion Proteins, bcr-abl; Humans; Lactams, Macrocyclic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasm Proteins; Philadelphia Chromosome; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1994 |
Requirement for tyrosine phosphorylation in lipopolysaccharide-induced murine B-cell proliferation.
Topics: Animals; B-Lymphocytes; Benzoquinones; Cell Division; Cells, Cultured; Genistein; Isoflavones; Lactams, Macrocyclic; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1993 |
Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes.
Topics: B-Lymphocytes; Benzoquinones; Calcium; Electrophoresis, Polyacrylamide Gel; Humans; Lactams, Macrocyclic; Phosphorylation; Quinones; Rifabutin; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Ultraviolet Rays | 1993 |
Thromboxane A2 stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release of endogenous basic fibroblast growth factor.
Topics: Animals; Base Sequence; Benzoquinones; DNA; Fibroblast Growth Factor 2; Humans; Hypertrophy; Lactams, Macrocyclic; Molecular Sequence Data; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase Inhibitors; Quinones; Rats; Rifabutin; Thromboxane A2; Tyrosine; Up-Regulation | 1993 |
p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.
Topics: Animals; Avian Sarcoma Viruses; Benzoquinones; Cadherins; Cell Adhesion; Cell Aggregation; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cytoskeletal Proteins; Fibroblasts; Lactams, Macrocyclic; Methionine; Oncogene Protein pp60(v-src); Phosphates; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1993 |
Phospholipase C activation in the cytotoxic response of human natural killer cells requires protein-tyrosine kinase activity.
Topics: Benzoquinones; Cell Line; Cytotoxicity, Immunologic; Enzyme Activation; Genistein; Humans; Isoflavones; Killer Cells, Natural; Lactams, Macrocyclic; Phospholipases; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1993 |
Genistein exhibits preferential cytotoxicity to a leukemogenic variant but induces differentiation of a non-leukemogenic variant of the mouse monocytic leukemia Mm cell line.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzoquinones; Cell Differentiation; Cell Division; Drug Screening Assays, Antitumor; Genistein; Isoflavones; Lactams, Macrocyclic; Leukemia, Monocytic, Acute; Mice; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.
Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Calcium; Cell Line; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Lactams, Macrocyclic; Leukocyte Common Antigens; Mice; Phosphorylation; Quinones; Receptors, IgG; Rifabutin; Tyrosine | 1993 |
Cross-linking of Fc gamma RIIIA on natural killer cells results in tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2.
Topics: Benzoquinones; Cells, Cultured; Cross-Linking Reagents; Humans; Isoenzymes; Killer Cells, Natural; Lactams, Macrocyclic; Phosphorylation; Quinones; Receptors, IgG; Rifabutin; Type C Phospholipases; Tyrosine | 1993 |
MHC class II molecules deliver costimulatory signals in human T cells through a functional linkage with IL-2-receptors.
Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Calcium; Histocompatibility Antigens Class II; HLA-DR Antigens; Interleukin-2; Lactams, Macrocyclic; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Mice; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Interleukin-2; Rifabutin; T-Lymphocytes; Tyrosine | 1993 |
Inhibition of protein tyrosine kinases impairs axon extension in the embryonic optic tract.
Topics: Animals; Antibody Specificity; Axons; Benzoquinones; Cells, Cultured; Chick Embryo; Ciliary Body; Embryo, Nonmammalian; Enzyme Inhibitors; Ganglia; Lactams, Macrocyclic; Neurites; Neurons; Optic Nerve; Phenols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Retina; Rifabutin; Signal Transduction; Superior Colliculi; Tyrosine; Visual Pathways; Xenopus laevis | 1996 |
Inhibition of PDGF-induced phospholipase C activation by herbimycin A.
Topics: 3T3 Cells; Animals; Benzoquinones; Enzyme Activation; Enzyme Inhibitors; Glycerophospholipids; Inositol Phosphates; Isoenzymes; Lactams, Macrocyclic; Mice; Phosphatidic Acids; Phospholipase C gamma; Phospholipase D; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1996 |
Effect of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils.
Topics: Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Isoflavones; Lactams, Macrocyclic; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Superoxides; Thiazepines; Tyrosine | 1996 |
Endothelin-1 induces tyrosine phosphorylation in human blood monocytes.
Topics: Adult; Antibodies, Blocking; Benzoquinones; Blotting, Western; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Female; Genistein; Humans; In Vitro Techniques; Isoflavones; Janus Kinase 1; Lactams, Macrocyclic; Male; Monocytes; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Quinones; Receptors, Endothelin; Rifabutin; src-Family Kinases; Time Factors; Tyrosine | 1996 |
A 100-kDa protein tyrosine phosphorylation is concurrent with beta 1 integrin-mediated morphological differentiation in neuroblastoma and small cell lung cancer cells.
Topics: Adenocarcinoma; Benzoquinones; Blotting, Western; Carcinoma, Small Cell; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Enzyme Inhibitors; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Lactams, Macrocyclic; Lung Neoplasms; Neuroblastoma; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptor, Insulin; Rifabutin; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1996 |
Role of tyrosine phosphorylation in radiation-induced cell cycle-arrest of leukemic B-cell precursors at the G2-M transition checkpoint.
Topics: B-Lymphocytes; Benzoquinones; CDC2 Protein Kinase; Cell Cycle Proteins; Enzyme Activation; G2 Phase; Hematopoietic Stem Cells; Humans; Lactams, Macrocyclic; Macromolecular Substances; Maturation-Promoting Factor; Neoplasm Proteins; Neoplastic Stem Cells; Nuclear Proteins; Peptide Fragments; Phosphorylation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Quinones; Recombinant Fusion Proteins; Rifabutin; Tumor Cells, Cultured; Tyrosine | 1996 |
Porphyromonas gingivalis surface components induce interleukin-1 release and tyrosine phosphorylation in macrophages.
Topics: Animals; Bacterial Outer Membrane Proteins; Bacterial Proteins; Benzoquinones; Enzyme Inhibitors; Female; Fimbriae Proteins; Genistein; Interleukin-1; Isoflavones; Lactams, Macrocyclic; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Phosphorylation; Porphyromonas gingivalis; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1996 |
C-Met signalling in an HGF/SF-insensitive variant MDCK cell line with constitutive motile/invasive behaviour.
Topics: Animals; Benzoquinones; Cell Line; Cell Movement; Cell Size; Dogs; Drug Resistance; Enzyme Inhibitors; Epidermal Growth Factor; Hepatocyte Growth Factor; Lactams, Macrocyclic; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Signal Transduction; Tyrosine | 1996 |
Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2).
Topics: Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Enzyme Activation; Genistein; Glycoproteins; Humans; Hydroquinones; Isoflavones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Osteosarcoma; Phosphorylation; Protease Inhibitors; Protein-Tyrosine Kinases; Proteins; Quinones; Rifabutin; Signal Transduction; Thymidine; Time Factors; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinases; Tritium; Tumor Cells, Cultured; Tyrosine | 1996 |
Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Benzoquinones; Cell Line, Transformed; Enzyme Inhibitors; Lactams, Macrocyclic; Lactones; Macrolides; Mice; Mitosis; Nocodazole; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Quinones; Rifabutin; RNA-Binding Proteins; src Homology Domains; Time Factors; Tyrosine | 1996 |
Infection of human T lymphoid cells by human herpesvirus 6 is blocked by two unrelated protein tyrosine kinase inhibitors, biochanin A and herbimycin.
Topics: Benzoquinones; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Genistein; Herpesvirus 6, Human; Humans; Isoflavones; Lactams, Macrocyclic; Leukocytes, Mononuclear; Lymphocytes; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; T-Lymphocytes; Tyrosine | 1996 |
Tyrosine phosphorylation events during coxsackievirus B3 replication.
Topics: Animals; Benzoquinones; Chlorocebus aethiops; Enterovirus B, Human; Enzyme Inhibitors; HeLa Cells; Humans; Lactams, Macrocyclic; Naphthalenes; Phosphorylation; Precipitin Tests; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Subcellular Fractions; Tyrosine; Vero Cells; Virion; Virus Replication | 1997 |
The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase.
Topics: Benzoquinones; Cell Cycle Proteins; Enzyme Inhibitors; Genistein; Humans; Interferon-alpha; Isoflavones; Lactams, Macrocyclic; Multiple Myeloma; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Quinones; Rifabutin; Staurosporine; Tumor Cells, Cultured; TYK2 Kinase; Tyrosine | 1997 |
Functional link between tyrosine phosphorylation and human serotonin transporter gene expression.
Topics: Benzoquinones; Carrier Proteins; Choriocarcinoma; Drug Interactions; Enzyme Inhibitors; Female; Gene Expression; Genistein; Humans; Isoflavones; Lactams, Macrocyclic; Membrane Glycoproteins; Membrane Transport Proteins; Neoplasm Proteins; Nerve Tissue Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Tumor Cells, Cultured; Tyrosine; Uterine Neoplasms | 1997 |
Myogenin expression is necessary for commitment to differentiation and is closely related to src tyrosine kinase activity in quail myoblasts transformed with Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Benzoquinones; Cell Differentiation; Cell Transformation, Viral; Clone Cells; Enzyme Inhibitors; Gene Expression; Lactams, Macrocyclic; Muscles; Myogenin; Phosphorylation; Protein Tyrosine Phosphatases; Quail; Quinones; Rifabutin; src-Family Kinases; Tyrosine; Vanadates | 1997 |
Tyrosine phosphorylation in DNA damage and cell death in hypoxic injury to LLC-PK1 cells.
Topics: Animals; Benzoquinones; Cell Death; DNA Damage; Enzyme Inhibitors; Hypoxia; Lactams, Macrocyclic; LLC-PK1 Cells; Phenols; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Swine; Tyrosine | 1997 |
Tyrosine phosphorylation is required for ehrlichial internalization and replication in P388D1 cells.
Topics: Animals; Benzoquinones; Ehrlichia; Genistein; Glutamine; Isoflavones; Lactams, Macrocyclic; Leukemia P388; Macrophages; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tyrosine | 1997 |
Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase.
Topics: Amino Acid Sequence; Animals; Benzoquinones; Catalysis; COS Cells; Enzyme Inhibitors; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mutagenesis, Site-Directed; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; src Homology Domains; src-Family Kinases; Substrate Specificity; Syk Kinase; Tyrosine | 1997 |
Involvement of protein tyrosine kinase p72syk and phosphatidylinositol 3-kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3.3.
Topics: Androstadienes; Benzoquinones; Carrier Proteins; CD2 Antigens; Cell Line; Cytoplasmic Granules; Enzyme Precursors; Exocytosis; Granzymes; Humans; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lactams, Macrocyclic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Proteins; Quinones; Rifabutin; Serine Endopeptidases; src Homology Domains; Syk Kinase; Tyrosine; Wortmannin | 1997 |
The CD40 ligand directly activates T-lymphocytes via tyrosine phosphorylation dependent PKC activation.
Topics: Antigens, Differentiation, T-Lymphocyte; Benzoquinones; CD40 Antigens; CD40 Ligand; Enzyme Activation; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Jurkat Cells; Lactams, Macrocyclic; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Quinones; Rifabutin; T-Lymphocytes; Type C Phospholipases; Tyrosine | 1997 |
Increased pressure induces sustained protein kinase C-independent herbimycin A-sensitive activation of extracellular signal-related kinase 1/2 in the rabbit aorta in organ culture.
Topics: Animals; Aorta; Benzoquinones; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Organ Culture Techniques; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rabbits; Rifabutin; Tyrosine | 1997 |
Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160.
Topics: Antibodies, Monoclonal; Antigens, CD; Benzoquinones; Carrier Proteins; Cell Fusion; Cell Line; Enzyme Activation; Enzyme Inhibitors; Fusion Regulatory Protein-1; Genes, Viral; Genistein; HIV Envelope Protein gp160; Humans; Lactams, Macrocyclic; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Transfection; Tyrosine | 1997 |
A suppressive role of p125FAK protein tyrosine kinase in hydrogen peroxide-induced apoptosis of T98G cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Benzoquinones; Cell Adhesion Molecules; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Hydrogen Peroxide; Lactams, Macrocyclic; Oligonucleotides, Antisense; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Thionucleotides; Tumor Cells, Cultured; Tyrosine | 1997 |
Cytokine-induced protein tyrosine phosphorylation is essential for cytokine priming of human eosinophils.
Topics: Benzoquinones; Cytokines; Enzyme Inhibitors; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Interleukin-3; Interleukin-5; Lactams, Macrocyclic; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Proteins; Quinones; Respiratory Burst; Rifabutin; Tyrosine; Zymosan | 1998 |
IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production.
Topics: Benzoquinones; Calcium; Cyclic AMP; Humans; Inositol 1,4,5-Trisphosphate; Insulin Receptor Substrate Proteins; Interleukin-13; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lactams, Macrocyclic; Monocytes; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Quinones; Reactive Oxygen Species; Respiratory Burst; Rifabutin; Type C Phospholipases; Tyrosine | 1998 |
Lipopolysaccharide protects polymorphonuclear leukocytes from apoptosis via tyrosine phosphorylation-dependent signal transduction pathways.
Topics: Apoptosis; Benzoquinones; Cell Survival; DNA Fragmentation; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Lactams, Macrocyclic; Lipopolysaccharides; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Respiratory Burst; Rifabutin; Signal Transduction; Tyrosine | 1998 |
Signal transduction of granulocyte macrophage-colony stimulating factor in a human endothelium-derived cell line.
Topics: Benzoquinones; Cell Cycle; Cell Line; Endothelium, Vascular; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Janus Kinase 2; Lactams, Macrocyclic; Neovascularization, Physiologic; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinones; Rifabutin; Signal Transduction; Tyrosine; Umbilical Veins | 1997 |
Constitutive activation of delayed-rectifier potassium channels by a src family tyrosine kinase in Schwann cells.
Topics: Animals; Benzoquinones; Cell Division; Cells, Cultured; Delayed Rectifier Potassium Channels; Enzyme Inhibitors; Genistein; Ion Channel Gating; Lactams, Macrocyclic; Mice; Phosphorylation; Potassium Channels; Potassium Channels, Voltage-Gated; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Recombinant Proteins; Rifabutin; Schwann Cells; Sciatic Nerve; Shab Potassium Channels; src-Family Kinases; Tyrosine | 1998 |
CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism.
Topics: Antigens, CD; Benzoquinones; Down-Regulation; Enzyme Inhibitors; Enzyme Precursors; Genistein; GTP-Binding Proteins; Humans; Interleukin-1; Interleukin-8; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Lipopolysaccharides; Molecular Weight; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Chemokine; Receptors, Interleukin; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Rifabutin; Signal Transduction; Syk Kinase; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 1998 |
Lipopolysaccharide induction of monocyte matrix metalloproteinases is regulated by the tyrosine phosphorylation of cytosolic phospholipase A2.
Topics: Arachidonic Acid; Benzoquinones; Collagenases; Cytosol; Dinoprostone; Enzyme Inhibitors; Humans; Lactams, Macrocyclic; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Monocytes; Phospholipases A; Phospholipases A2; Phosphorylation; Quinones; Rifabutin; Signal Transduction; Tyrosine | 1998 |
Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride.
Topics: Arsenites; Benzoquinones; Cadmium Chloride; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Induction; Enzyme Inhibitors; HeLa Cells; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Humans; Lactams, Macrocyclic; Membrane Proteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Sodium Compounds; Transcription, Genetic; Tyrosine | 1998 |
Protein tyrosine phosphorylation in signalling pathways leading to the activation of gelatinase A: activation of gelatinase A by treatment with the protein tyrosine phosphatase inhibitor sodium orthovanadate.
Topics: Base Sequence; Benzoquinones; Cells, Cultured; DNA Primers; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gelatinases; Humans; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Monensin; Phosphorylation; Protein Tyrosine Phosphatases; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Signal Transduction; Tissue Inhibitor of Metalloproteinase-2; Tyrosine; Vanadates | 1998 |
Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Antigen-Antibody Complex; Benzoquinones; Catalase; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Hydrogen Peroxide; Kinetics; Lactams, Macrocyclic; Mice; Phospholipase D; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Quinones; Rats; Receptors, Platelet-Derived Growth Factor; Rifabutin; Tyrosine; Vanadates | 1998 |
Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Benzoquinones; DNA; DNA, Neoplasm; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; Humans; KB Cells; Lactams, Macrocyclic; Mice; Phosphorylation; Platelet-Derived Growth Factor; Quinones; Rats; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, Insulin; Receptors, Platelet-Derived Growth Factor; Rifabutin; Signal Transduction; src-Family Kinases; Stimulation, Chemical; Tumor Cells, Cultured; Tyrosine | 1998 |
Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts.
Topics: Amino Acid Sequence; Benzoquinones; Cell Adhesion; Cell Polarity; Cytoplasm; Fibroblasts; Genistein; Lactams, Macrocyclic; Membrane Glycoproteins; Molecular Sequence Data; Phosphorylation; Protein Kinase Inhibitors; Proteoglycans; Quinones; Rifabutin; src-Family Kinases; Staurosporine; Syndecan-2; Syndecan-4; Syndecans; Tyrosine | 1998 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
ECM-stimulated actin bundle formation in embryonic corneal epithelia is tyrosine phosphorylation dependent.
Topics: Actins; Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Communication; Cells, Cultured; Chick Embryo; Collagen; Epithelium, Corneal; Extracellular Matrix Proteins; Fibronectins; Humans; Lactams, Macrocyclic; Microscopy, Confocal; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinones; Rifabutin; Time Factors; Tyrosine | 1999 |
Tyrosine phosphorylation/dephosphorylation controls capping of Fcgamma receptor II in U937 cells.
Topics: Arsenicals; Bacterial Proteins; Benzoquinones; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoblotting; Lactams, Macrocyclic; Microscopy, Fluorescence; Okadaic Acid; Phosphorylation; Quinones; Receptor Aggregation; Receptors, IgG; Rifabutin; Streptolysins; Temperature; Time Factors; Tyrosine; U937 Cells; Vanadates | 1999 |
CD45 modulation of CXCR1 and CXCR2 in human polymorphonuclear leukocytes.
Topics: Antibodies, Monoclonal; Antigens, CD; Benzoquinones; Cells, Cultured; Chemokine CCL2; Chemokine CCL4; Down-Regulation; Genistein; Humans; Interleukin-8; Lactams, Macrocyclic; Leukocyte Common Antigens; Macrophage Inflammatory Proteins; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Chemokine; Receptors, Interleukin; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Rifabutin; Tyrosine | 1999 |
Influence of phosphotyrosine kinase inhibitors on adhesive properties of highly and poorly metastatic HT-29 colon carcinoma cells to collagen.
Topics: Benzoquinones; Cell Adhesion; Collagen; Genistein; HT29 Cells; Humans; Integrins; Lactams, Macrocyclic; Neoplasms; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Vitronectin; Rifabutin; Tyrosine | 1999 |
Secretory phospholipase A2 induces phospholipase Cgamma-1 activation and Ca2+ mobilization in the human astrocytoma cell line 1321N1 by a mechanism independent of its catalytic activity.
Topics: Astrocytoma; Benzoquinones; Caffeine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Enzyme Inhibitors; Humans; Isoenzymes; Lactams, Macrocyclic; Models, Biological; Pertussis Toxin; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phospholipases A; Phospholipases A2; Phosphorylation; Quinones; Rifabutin; Signal Transduction; Time Factors; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Virulence Factors, Bordetella | 1999 |
Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells.
Topics: Actin Depolymerizing Factors; Actins; Antibodies; Benzoquinones; Biological Transport; Cell Membrane; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Lactams, Macrocyclic; Macrophages; Microfilament Proteins; Microinjections; Opsonin Proteins; Phosphorylation; Quinones; Rifabutin; Superoxides; Tyrosine; U937 Cells; Zymosan | 1999 |
Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly.
Topics: Actins; Animals; Benzoquinones; Blotting, Western; Cell Differentiation; Cells, Cultured; Cornea; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Fibroblasts; Fibronectins; Fluorescent Antibody Technique, Indirect; Lactams, Macrocyclic; Oligopeptides; Phosphorylation; Quinones; Rabbits; Rifabutin; RNA, Messenger; Transforming Growth Factor beta; Tyrosine | 1999 |
Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation.
Topics: Benzoquinones; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Crk-Associated Substrate Protein; CSK Tyrosine-Protein Kinase; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Pyrazoles; Pyrimidines; Quinones; Retinoblastoma-Like Protein p130; Rifabutin; src-Family Kinases; Stress, Mechanical; Tyrosine | 1999 |
Maintenance of GPIIb-IIIa avidity supporting "irreversible" fibrinogen binding is energy-dependent.
Topics: Adenosine Diphosphate; Androstadienes; Anti-Bacterial Agents; Antibodies, Monoclonal; Antimetabolites; Antimycin A; Benzoquinones; Blood Platelets; Deoxyglucose; Dimethyl Sulfoxide; Energy Metabolism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excipients; Fibrinogen; Humans; Lactams, Macrocyclic; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Polylysine; Protein Binding; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Tyrosine; Wortmannin | 1999 |
Novel association of the src family kinases, hck and c-fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis.
Topics: Benzoquinones; Chemokine CCL11; Chemokines, CC; Chemotaxis, Leukocyte; Cytokines; Drug Synergism; Enzyme Inhibitors; Eosinophils; Humans; Lactams, Macrocyclic; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Quinones; Receptors, CCR3; Receptors, Chemokine; Rifabutin; src-Family Kinases; Tyrosine; Vanadates | 1999 |
VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction.
Topics: Actomyosin; Animals; Benzoquinones; beta Catenin; Biological Transport; Capillary Permeability; Cattle; Cell Division; Cytoskeletal Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Indoles; Intercellular Junctions; Lactams, Macrocyclic; Lymphokines; Maleimides; Phosphorylation; Quinones; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Rifabutin; Time Factors; Trans-Activators; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Tyrosine phosphorylation of a low molecular weight protein induced by RANTES in T-lymphocytes.
Topics: Benzoquinones; CD3 Complex; Cell Line; Chemokine CCL5; Dose-Response Relationship, Drug; Enzyme Inhibitors; HIV-1; Humans; Lactams, Macrocyclic; Lymphocyte Activation; Molecular Weight; Neutralization Tests; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, T-Cell; Receptors, CCR5; Rifabutin; Signal Transduction; T-Lymphocytes; Time Factors; Tyrosine | 1999 |
Inhibition of I kappaB-alpha phosphorylation at serine and tyrosine acts independently on sensitization to DNA damaging agents in human glioma cells.
Topics: Antineoplastic Agents; Benzoquinones; Cell Cycle; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Radiation; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Glioma; Humans; I-kappa B Kinase; Lactams, Macrocyclic; Ligases; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Quinones; Radiation Tolerance; Rifabutin; Sequence Deletion; Serine; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Ultraviolet Rays | 2000 |
Differential induction of tumor necrosis factor alpha and manganese superoxide dismutase by endotoxin in human monocytes: role of protein tyrosine kinase, mitogen-activated protein kinase, and nuclear factor kappaB.
Topics: Benzoquinones; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Humans; Lactams, Macrocyclic; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Monocytes; NF-kappa B; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells.
Topics: Animals; Benzoquinones; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Genistein; Insulin Receptor Substrate Proteins; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Morpholines; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rifabutin; Tyrosine | 2000 |
Regulation of microglial tyrosine phosphorylation in response to neuronal injury.
Topics: Animals; Anterior Horn Cells; Benzoquinones; Denervation; Enzyme Inhibitors; Ganglia, Spinal; Lactams, Macrocyclic; Microglia; Nerve Degeneration; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Ricin; Rifabutin; Sciatic Nerve; Tyrosine | 2000 |
Protein tyrosine phosphorylation induced by ubiquitin-like polypeptide in murine T helper clone type 2.
Topics: Animals; Antibodies; Benzoquinones; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoblotting; Interferon-gamma; Interleukin-4; Lactams, Macrocyclic; Mice; Phosphorylation; Protein Isoforms; Protein-Tyrosine Kinases; Proteins; Quinones; Receptors, Cell Surface; Rifabutin; Signal Transduction; Suppressor Factors, Immunologic; Th2 Cells; Tyrosine | 2000 |
Cloning and functional expression of rKCNQ2 K(+) channel from rat brain.
Topics: Animals; Benzoquinones; Brain Chemistry; Cells, Cultured; Cloning, Molecular; Enzyme Inhibitors; Epilepsy; Gene Expression; Genistein; Humans; KCNQ2 Potassium Channel; Kidney; Lactams, Macrocyclic; Membrane Potentials; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; RNA, Messenger; Sequence Homology, Amino Acid; Tetraethylammonium; Tyrosine; Xenopus | 2000 |
Pamlin-induced tyrosine phosphorylation of SUp62 protein in primary mesenchyme cells during early embryogenesis in the sea urchin, Hemicentrotus pulcherrimus.
Topics: Animals; Benzoquinones; Chromatography, Affinity; Embryo, Nonmammalian; Embryonic Development; Enzyme Inhibitors; Glycoproteins; Immunohistochemistry; Lactams, Macrocyclic; Mesoderm; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Quinones; Receptors, Cell Surface; Rifabutin; Sea Urchins; Tyrosine | 2000 |
Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells.
Topics: Animals; Benzoquinones; Butadienes; Cells, Cultured; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrogens; Female; Flavonoids; Gene Expression Regulation; Lactams, Macrocyclic; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pituitary Gland; Prolactin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyrazoles; Pyrimidines; Quinones; Rats; Rats, Inbred F344; Rifabutin; RNA, Messenger; Signal Transduction; src-Family Kinases; Steroids; Transcription, Genetic; Tyrosine | 2000 |
Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases.
Topics: Actins; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Benzoquinones; Cell Line; Cell Line, Transformed; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Fibroblasts; Focal Adhesions; Lactams, Macrocyclic; Mice; Microscopy, Fluorescence; Microtubules; Nocodazole; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Phosphatase 2; Quinones; Rifabutin; src-Family Kinases; Stress Fibers; Tyrosine; Vimentin | 2000 |
Insulin increased cAMP phosphodiesterase activity antagonizing metabolic actions of glucagon in rat hepatocytes cultured with herbimycin A.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzoquinones; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Hepatocytes; Insulin; Lactams, Macrocyclic; Male; Microtubules; Phosphatidylinositol 3-Kinases; Phosphorylases; Phosphorylation; Quinones; Rats; Rats, Wistar; Rifabutin; Tubulin; Tyrosine | 2000 |
Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase.
Topics: Alanine; Animals; Benzoquinones; Blotting, Western; Colchicine; Concanavalin A; Enzyme Inhibitors; Lactams, Macrocyclic; Microscopy, Fluorescence; Microtubules; Models, Biological; Mutation; Oocytes; Paclitaxel; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Complementary; Sucrose; Time Factors; Tyrosine; Xenopus | 2001 |
Involvement of alpha5beta1 integrins in interleukin 8 production induced by oral viridans streptococcal protein I/IIf in cultured endothelial cells.
Topics: Adhesins, Bacterial; Animals; Apigenin; Bacterial Proteins; Benzoquinones; Cells, Cultured; CHO Cells; Cricetinae; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Guanosine Diphosphate; Humans; Immunoblotting; Integrins; Interleukin-8; Isoenzymes; Lactams, Macrocyclic; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Paxillin; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Quinones; Receptors, Vitronectin; Rifabutin; Streptococcus mutans; Thionucleotides; Type C Phospholipases; Tyrosine | 1999 |
PTH stimulates PLCbeta and PLCgamma isoenzymes in rat enterocytes: influence of ageing.
Topics: Aging; Animals; Benzoquinones; Blotting, Western; Cells, Cultured; Duodenum; Electrophoresis, Polyacrylamide Gel; Enterocytes; Genistein; Inositol Phosphates; Isoenzymes; Lactams, Macrocyclic; Male; Parathyroid Hormone; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Isoforms; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Wistar; Rifabutin; Subcellular Fractions; Time Factors; Type C Phospholipases; Tyrosine | 2001 |
UCS15A, a non-kinase inhibitor of Src signal transduction.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Anti-Bacterial Agents; Benzaldehydes; Benzoquinones; Bone Resorption; Cell Transformation, Neoplastic; Cortactin; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Genes, src; Humans; Lactams, Macrocyclic; Lactones; Macrolides; Male; Mice; Microfilament Proteins; Organ Culture Techniques; Osteoclasts; Phosphorylation; Quinones; Rats; Rifabutin; RNA-Binding Proteins; Signal Transduction; src-Family Kinases; Tyrosine | 2001 |
PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation.
Topics: Animals; Anticoagulants; Becaplermin; Benzoquinones; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Fibroblasts; Lactams, Macrocyclic; Lung; Male; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutagenesis; Nitriles; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins c-sis; Quinones; Rats; Rats, Wistar; Receptor, Platelet-Derived Growth Factor beta; Rifabutin; Threonine; Transfection; Tyrosine; Tyrphostins | 2001 |
Phosphorylation-induced activation of tilapia nonspecific cytotoxic cells by serum cytokines.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Benzoquinones; Blotting, Western; Camptothecin; Cell Cycle; Cold Temperature; Cytokines; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Female; Flow Cytometry; Killer Cells, Natural; Kinetics; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Stress, Physiological; Tilapia; Tyrosine; Vanadates | 2001 |
Involvement of protein tyrosine phosphorylation and reduction of cellular sulfhydryl groups in cell death induced by 1' -acetoxychavicol acetate in Ehrlich ascites tumor cells.
Topics: Animals; Anticarcinogenic Agents; Benzoquinones; Benzyl Alcohols; Blotting, Western; Carcinoma, Ehrlich Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutathione; Lactams, Macrocyclic; Oxidation-Reduction; Phosphorylation; Quinones; Rifabutin; Sulfhydryl Compounds; Terpenes; Time Factors; Tumor Cells, Cultured; Tyrosine | 2002 |
Regulation of an ERG K+ current by Src tyrosine kinase.
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Blotting, Western; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Genistein; Humans; Kinetics; Lactams, Macrocyclic; Peptides; Phenols; Phosphorylation; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Precipitin Tests; Protein-Tyrosine Kinases; Quinones; Rats; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; Signal Transduction; src-Family Kinases; Time Factors; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tyrosine | 2002 |
Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors.
Topics: Animals; Benzoquinones; Cells, Cultured; Cytoskeletal Proteins; Dystroglycans; Dystrophin-Associated Proteins; Enzyme Inhibitors; Lactams, Macrocyclic; Laminin; Membrane Glycoproteins; Membrane Proteins; Muscle Proteins; Neuromuscular Junction; Neuropeptides; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Rifabutin; Signal Transduction; src-Family Kinases; Staurosporine; Synapses; Tyrosine; Utrophin | 2002 |
Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles.
Topics: Angiotensin II; Animals; Antibodies; Benzoquinones; Calmodulin-Binding Proteins; Digestive System; Digestive System Physiological Phenomena; Enzyme Inhibitors; Female; Flavonoids; Genistein; In Vitro Techniques; Lactams, Macrocyclic; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; p120 GTPase Activating Protein; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Tyrosine | 2002 |
Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cells.
Topics: Benzoquinones; Cell Line; Down-Regulation; Epithelial Cells; Humans; Lactams, Macrocyclic; Lung; Phosphorylation; Quinones; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Rifabutin; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tyrosine | 2004 |
Initial signaling of the fibronectin receptor (alpha5beta1 integrin) in hepatic stellate cells is independent of tyrosine phosphorylation.
Topics: Animals; Benzoquinones; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Extracellular Matrix; Genistein; Integrin alpha5beta1; Lactams, Macrocyclic; Ligands; Liver; Male; Microspheres; Phosphorylation; Polylysine; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Signal Transduction; Tyrosine | 2003 |
Tyrosine phosphorylation is involved in Ca(2+)entry in human gingival fibroblasts.
Topics: Benzoquinones; Bradykinin; Calcium; Calcium Channels; Enzyme Inhibitors; Fibroblasts; Gingiva; Histamine; Humans; Lactams, Macrocyclic; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptors, Histamine H1; Rifabutin; Thapsigargin; Time Factors; Tyrosine; Tyrphostins | 2003 |
[The role of tyrosine phosphorylation proteins in procollagen gene expression of fibroblasts in wound healing].
Topics: Adolescent; Adult; Benzoquinones; Blotting, Western; Child; Female; Fibroblasts; Gene Expression; Humans; Lactams, Macrocyclic; Male; Phosphoproteins; Phosphorylation; Procollagen; Quinones; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Skin; Tyrosine; Wound Healing | 2004 |
Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin.
Topics: Benzoquinones; Caco-2 Cells; Chloride-Bicarbonate Antiporters; Chlorides; CSK Tyrosine-Protein Kinase; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Humans; Lactams, Macrocyclic; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinones; Receptors, Serotonin; Rifabutin; Serotonin; Serotonin Antagonists; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrosine | 2005 |
Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase.
Topics: Adherens Junctions; Animals; Antigens, CD; Benzoquinones; Cadherins; Cell Line; Embryo, Mammalian; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Heart; Immunosorbent Techniques; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Quinones; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Tyrosine; Tyrphostins | 2005 |
Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells.
Topics: Adaptor Proteins, Signal Transducing; Benzoquinones; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Erythroid Cells; Glutathione Transferase; GRB2 Adaptor Protein; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Phosphorylation; Proto-Oncogene Proteins p21(ras); Quinones; Rifabutin; Signal Transduction; Tyrosine | 2005 |
Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gallbladder; Gefitinib; Humans; Inhibitory Concentration 50; Lactams, Macrocyclic; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rifabutin; Signal Transduction; Tyrosine | 2006 |
Herbimycin A suppresses mitotic activity and egg production of female Schistosoma mansoni.
Topics: Animals; Benzoquinones; Dimethyl Sulfoxide; DNA, Helminth; Egg Proteins; Enzyme Inhibitors; Female; Gene Expression; Helminth Proteins; Lactams, Macrocyclic; Male; Mitosis; Parasite Egg Count; Phosphorylation; Protein Precursors; Protein-Tyrosine Kinases; Rifabutin; Schistosoma mansoni; Solvents; src-Family Kinases; Tyrosine | 2006 |
RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3.
Topics: Amides; Animals; Benzoquinones; Cell Line; Enzyme Inhibitors; Exocytosis; Focal Adhesion Kinase 1; Hydrochloric Acid; Hydrogen-Ion Concentration; Lactams, Macrocyclic; Opossums; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; rhoA GTP-Binding Protein; Rifabutin; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Stress Fibers; Tyrosine | 2007 |
The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells.
Topics: Active Transport, Cell Nucleus; Benzoquinones; Caco-2 Cells; Genistein; Humans; Intestinal Mucosa; Intestines; Lactams, Macrocyclic; Phosphorylation; Polychlorinated Dibenzodioxins; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Protein Stability; Protein-Tyrosine Kinases; Receptors, Aryl Hydrocarbon; Reproducibility of Results; Rifabutin; Transcriptional Activation; Tyrosine; Tyrphostins | 2010 |
Tumor necrosis factor α stimulates expression and secretion of urokinase plasminogen activator in human dental pulp cells.
Topics: Cells, Cultured; Dental Pulp; Genistein; Humans; Interleukin-1; NF-kappa B; Phosphorylation; Plasminogen Activators; Pyrrolidines; Rifabutin; Thiocarbamates; Tumor Necrosis Factor-alpha; Tyrosine; Vanadates | 2012 |
Tyrosine Phosphorylation of Focal Adhesion Anchoring Proteins Enhances Human Pancreatic Cancer Cell Invasion.
Topics: Animals; Blotting, Western; Cattle; Cell Line; Cell Line, Tumor; Cell Movement; Crk-Associated Substrate Protein; Endothelial Cells; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Pulmonary Artery; Rifabutin; Tyrosine | 2016 |