Compounds > tyrosine

tyrosine and guanosine triphosphate

tyrosine has been researched along with guanosine triphosphate in 107 studies

Research

Studies (107)

TimeframeStudies, this research(%)All Research%
pre-199023 (21.50)18.7374
1990's39 (36.45)18.2507
2000's31 (28.97)29.6817
2010's12 (11.21)24.3611
2020's2 (1.87)2.80

Authors

AuthorsStudies
Cooper, DM; Glynn, P; Schulster, D1
Cramer, F; Hobbs, JB; Kucharzewski, M; Sprinzl, M1
Krauss, G; Maass, G; Peters, F; Pingoud, A; Urbanke, C1
Carlson, GM; Colombo, G; Lardy, HA1
Maitra, U; Schulman, LH; Stringer, EA; Sundari, RM1
Barra, HS; Caputto, R; Hallak, ME; Rodriguez, JA1
Bastin, M; Hall, TC1
Contreras, R; Khorana, HG; Küpper, H; Landy, A1
Abraham, S; Dryden, P; Duronio, V; Schrader, JW; Welham, MJ1
Adamson, JW; Altschuler, D; Komatsu, N; Lapetina, EG; Marzocchini, R; Torti, M; Yamamoto, K1
Green, SH; Qui, MS1
Altschuler, D; Lapetina, EG; Marti, KB; Torti, M; Yamamoto, K1
Downey, GP; Grinstein, S; Pâquet, MR; Trudel, S1
Kilgour, E; Larner, J; Luttrell, L; Romero, G1
McCormick, F1
Burns, RG; Idriss, H; Ross, CK; Stammers, DK1
Green, SH; Qiu, MS1
Burdett, E; Klip, A; Mills, GB1
Chardin, P; Frech, M; John, J; Rösch, P; Schlichting, I; Wittinghofer, A; Zimmermann, H1
Cooper, JA; Coussens, PM; Hunter, T; Shalloway, D1
Hoffbrand, AV; Mire-Sluis, AR; Wickremasinghe, RG1
Frank, DA; Sartorelli, AC1
MacDermot, J; McEwan, JR; Ritter, JM1
Grinstein, S; Mills, GB; Nasmith, PE1
Burns, RG; Islam, K1
Kirschner, M; Mitchison, T1
Chen, CM; Ofengand, J1
D'Iorio, A; Mavrides, C; Whitlow, KJ1
Reichard, P1
Brattin, WJ; Landon, M; Langley, TJ; Melamed, MD; Piszkiewicz, D; Smith, EL1
Hunter, T1
Dasgupta, A; Hocko, J; Morrow, CD; Navab, M1
Colman, RF; Jacobson, MA2
Corrie, JE; Franken, SM; Goody, RS; Pai, EF; Reid, GP; Scheidig, AJ; Wittinghofer, A1
Grünbaum, L; Hagelüken, A; Höer, A; Höer, D; Offermanns, S; Schultz, G; Schunack, W; Schwaner, I; Seifert, R; Zingel, V1
Hattori, S; Katagiri, K; Katagiri, T; Nakamura, S; Yamamoto, T; Yoshida, T1
Lambowitz, AM; Lee, JC; Patel, SS; Saldanha, RJ; Surendran, R1
Briend-Sutren, MM; Cazaubon, SM; Lazard, D; Nahmias, C; Strosberg, AD; Villageois, P1
Bos, JL; Hordijk, PL; Medema, RH; Moolenaar, WH; van Corven, EJ1
Chang, JH; Moyers, JS; Parsons, SJ; Wilson, LK; Zhang, K1
Ohmichi, M; Pang, L; Ribon, V; Saltiel, AR1
Bos, JL; Cheatham, B; Kahn, CR; Maassen, JA; Möller, W; Ouwens, DM; Pronk, GJ; van der Zon, GC1
Altman, A; Baier, G; Bonnefoy-Berard, N; Coggeshall, KM; Gulbins, E; Herbert, E; Langlet, C1
Eccleston, JF; Feeney, J; Hinds, MG; King, RW; Molloy, DP1
Baltensperger, K; Banerjee, U; Chawla, A; Cherniack, AD; Czech, MP; Klarlund, JK; Kozma, LM1
Allison, WS; Di Pietro, A; Divita, G; Jault, JM1
Molina, IJ; Remold-O'Donnell, E; Rosen, FS; Sancho, J; Terhorst, C1
Buckley, AR; Buckley, DJ; Rao, YP1
Light, Y; Marais, R; Marshall, CJ; Mason, CS; Paterson, HF1
Henkemeyer, M; Jacks, T; Pawson, T; van der Geer, P1
Bos, JL; Burgering, BM; de Rooij, J; Downward, J; Marte, B; van Weering, DH1
Chiba, T; Kawanami, C; Kinoshita, Y; Kishi, K; Nakata, H; Sawada, M1
Engelhard, M; Goody, RS; Herrmann, C; Sydor, JR; Wittinghofer, A1
Barnard, D; Clawson, D; Diaz, B; Marshall, M1
Hattori, Y; Kanno, M; Kitabatake, A; Kohya, T; Moriishi, K; Oguma, K; Sasaki, M; Tomita, F1
Carloni, C; Catalioto, RM; Criscuoli, M; Cucchi, P; Giolitti, A; Maggi, CA; Renzetti, AR; Rotondaro, L; Zappitelli, S1
Kemp, RG; Wang, X1
Davis, AR; Nelson, LK; Quinn, MT; Rohn, TT1
Arvidsson, AK; Engström, U; Heldin, CH; Hellman, U; Kallin, A; Rönnstrand, L; Rorsman, C; Wernstedt, C1
Haugh, JM; Huang, AC; Lauffenburger, DA; Wells, A; Wiley, HS1
Durden, DL; Erdreich-Epstein, A; Izadi, KD; Liu, M; Park, RK1
Ali-Osman, F; Mullapudi, SR; Shou, J; Srivenugopal, KS1
Bell, MW; Desai, N; Ghalayini, AJ; Guo, XX1
Hilgenfeld, R; Mesters, JR; Palm, GJ; Vogeley, L1
Groll, DH; Hanke, S; Liebmann, C; Nürnberg, B1
Faure, R; Fiset, A1
Bamford, DH; Laurila, MR; Makeyev, EV1
Gesbert, F; Griffin, JD; Gu, H; Iwasaki, H; Li, S; Malouf, NA; Mohi, MG; Neel, BG; Podar, K; Pride, YB; Quinnan, LR; Sattler, M; Van Etten, RA1
Abassi, YA; Vuori, K1
Crottet, P; Meyer, DM; Rohrer, J; Spiess, M1
Cerione, RA; Fidyk, NJ1
Oehrl, W; Rubio, I; Wetzker, R1
Ziegler, I1
Kamioka, Y; Kunimoto, S; Masuda, M; Mochizuki, N; Ogita, H; Sawa, H1
Ching, YP; Kung, HF; Leong, VY; Wong, CM1
Marcoux, N; Vuori, K1
Choi, WS; Sung, CK1
Gross, S; Meurer, S; Müller-Esterl, W; Pioch, S; Wagner, K1
Olefsky, JM; Ricketts, W; Sharma, PM; Son, HS; Ugi, S1
Ahmadian, MR; Blöchl, A; Blumenstein, L1
Drobot, L; Husak, Z; Igumentseva, N; Ilnytska, O; Kusen', S; Oleksyn, H1
Bezard, E; Guo, S; Zhao, B1
Hawkins, AR; Kotaka, M; Lamb, HK; Lockyer, M; Ren, J; Stammers, DK1
Cerione, RA; Hamel, B; Smith, WJ; Snyder, JT; Sondek, J; Yohe, ME1
Frank, SJ; Franklin, JL; Keeton, AB; Li, X; Messina, JL; Venable, DY; Xu, J1
Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y1
Abramow-Newerly, M; Chidiac, P; Ming, H1
Begg, GE; Carrington, L; Graham, RM; Husain, A; Iismaa, SE; Lorand, L; Matthews, JM; Stokes, PH; Wouters, MA1
Song, P; Wang, S; Wu, Y; Xu, J; Zhang, M; Zou, MH1
Doray, B; Govero, J; Kornfeld, S; Lee, I1
Case, CL; Dharmarajan, L; Dunten, P; Mukhopadhyay, B1
Grigoryan, H; Lockridge, O1
Deng, S; Derbyshire, ER; Marletta, MA1
Alan, JK; Berzat, AC; Cox, AD; Dewar, BJ; Graves, LM1
Brucker, S; Gerwert, K; Kötting, C1
Hanafusa, H; Ishikawa, K; Matsumoto, K; Nara, A1
Gerwert, K; Kötting, C; Rudack, T; Schlitter, J; Xia, F1
Bhattacharya, M; Smith, CA; Toth, M; Vakulenko, SB1
Collins, RE; Del Campo, CM; Lambright, DG; Mishra, AK; Roy, CR1
Sachdeva, A; Silverman, SK; Walsh, SM1
Brucker, S; Gerwert, K; Jenrich, S; Kötting, C; Rudack, T; Vetter, IR1
Bomblies, R; Itzen, A; Luitz, MP; Ramcke, E; Zacharias, M1
Begieneman, MP; Fritz, J; Krijnen, PA; Kubat, B; Leen, R; Meinster, E; Musters, RJ; Niessen, HW; Pankras, JE; Rijvers, L; Stap, J; Ter Horst, EN; van Kuilenburg, AB1
McPherson, PS; Xu, J1
Baumann, T; Budisa, N; Dragelj, J; Jia, H; Kendall, O; Kubyshkin, V; Mroginski, MA; Schwille, P; Sun, H1
Higaki, T; Hotta, T; Ohi, R; Verhey, KJ; Yue, Y1

Reviews

4 review(s) available for tyrosine and guanosine triphosphate

ArticleYear
The world according to GAP.
    Oncogene, 1990, Volume: 5, Issue:9

    Topics: Enzyme Activation; Gene Expression Regulation, Enzymologic; Genes, Fungal; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Oncogene Protein p21(ras); Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Saccharomyces cerevisiae; Tyrosine

1990
Beyond self-assembly: from microtubules to morphogenesis.
    Cell, 1986, May-09, Volume: 45, Issue:3

    Topics: Animals; Cells, Cultured; Centrioles; Cytoskeleton; Guanosine Diphosphate; Guanosine Triphosphate; Microtubules; Morphogenesis; Polymers; Spindle Apparatus; Tubulin; Tyrosine

1986
Checkpoints for vesicular traffic?
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2001, Volume: 79, Issue:5

    Topics: Animals; CDC2-CDC28 Kinases; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Endosomes; Guanosine Triphosphate; Interphase; Ligands; Mitosis; Models, Biological; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine

2001
The pteridine pathway in zebrafish: regulation and specification during the determination of neural crest cell-fate.
    Pigment cell research, 2003, Volume: 16, Issue:3

    Topics: Animals; Biopterins; Cell Lineage; Gene Expression Regulation, Developmental; GTP Cyclohydrolase; Guanosine Triphosphate; Melanophores; Models, Biological; Models, Chemical; Mutation; Neural Crest; Neurons; Phenotype; Pigments, Biological; Pteridines; Pterins; Signal Transduction; Time Factors; Tyrosine; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthopterin; Zebrafish

2003

Other Studies

103 other study(ies) available for tyrosine and guanosine triphosphate

ArticleYear
The regulation of adenylate cyclase of the adrenal cortex.
    Molecular and cellular endocrinology, 1979, Volume: 13, Issue:2

    Topics: Adenosine; Adenylyl Cyclases; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Binding Sites; Calcium; Cell Membrane; Cyclic AMP; Guanosine Triphosphate; Guanylate Cyclase; Guanylyl Imidodiphosphate; Iodine; Kinetics; Magnesium; Peptide Fragments; Protein Binding; Tyrosine

1979
Specificity of elongation factor Tu from Escherichia coli with respect to attachment to the amino acid to the 2' or 3'-hydroxyl group of the terminal adenosine of tRNA.
    European journal of biochemistry, 1977, Aug-15, Volume: 78, Issue:1

    Topics: Adenosine; Escherichia coli; Guanosine Triphosphate; Peptide Elongation Factors; Phenylalanine; Protein Binding; RNA, Transfer; RNA, Transfer, Amino Acyl; Saccharomyces cerevisiae; Structure-Activity Relationship; Tyrosine

1977
Ternary complex formation between elongation factor Tu, GTP and aminoacyl-tRNA: an equilibrium study.
    European journal of biochemistry, 1977, Volume: 78, Issue:2

    Topics: Calorimetry; Drug Stability; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Peptide Elongation Factors; Phenylalanine; RNA, Transfer, Amino Acyl; Serine; Temperature; Thermodynamics; Tyrosine

1977
Phosphoenolpyruvate carboxykinase (guanosine triphosphate) from rat liver cytosol. Separation of homogeneous forms of the enzyme with high and low activity by chromatography on agarose-hexane-guanosine triphosphate.
    Biochemistry, 1978, Dec-12, Volume: 17, Issue:25

    Topics: Adenosine Triphosphate; Animals; Chromatography, Affinity; Cysteine; Cytosol; Dithionitrobenzoic Acid; Guanosine Triphosphate; Kinetics; Ligands; Liver; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Tryptophan; Tyrosine

1978
Interaction of bacterial initiation factor 2 with initiator tRNA.
    The Journal of biological chemistry, 1976, Jun-10, Volume: 251, Issue:11

    Topics: Amino Acyl-tRNA Synthetases; Ammonia; Base Sequence; Binding Sites; Escherichia coli; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Magnesium; Methionine; Peptide Elongation Factors; Peptide Initiation Factors; Protein Binding; Ribosomes; RNA, Transfer; Species Specificity; Tyrosine

1976
Release of tyrosine from tyrosinated tubulin. Some common factors that affect this process and the assembly of tubulin.
    FEBS letters, 1977, Feb-01, Volume: 73, Issue:2

    Topics: Adenosine Diphosphate; Animals; Brain; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Guanosine Triphosphate; Macromolecular Substances; Magnesium; Molecular Weight; Protein Binding; Rabbits; Tubulin; Tyrosine

1977
Interaction of elongation factor 1 with aminoacylated brome mosaic virus and tRNA's.
    Journal of virology, 1976, Volume: 20, Issue:1

    Topics: Guanosine Triphosphate; Mosaic Viruses; Peptide Elongation Factors; Plant Viruses; RNA, Transfer; RNA, Viral; Triticum; Tyrosine

1976
Promoter-dependent transcription of tRNAITyr genes using DNA fragments produced by restriction enzymes.
    Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:12

    Topics: Adenosine Triphosphate; Base Sequence; Cytosine Nucleotides; DNA Restriction Enzymes; DNA, Bacterial; Endonucleases; Escherichia coli; Genes; Guanosine Triphosphate; Heparin; Oligonucleotides; Rifampin; RNA Nucleotidyltransferases; RNA, Transfer; Transcription, Genetic; Tyrosine

1975
p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Mar-01, Volume: 89, Issue:5

    Topics: Animals; Cells, Cultured; Cytokines; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; In Vitro Techniques; Interleukin-3; Mast Cells; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Receptors, Cell Surface; Signal Transduction; Tyrosine

1992
Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7.
    Blood, 1992, Jul-01, Volume: 80, Issue:1

    Topics: Erythropoietin; Guanosine Triphosphate; Hematopoiesis; Humans; In Vitro Techniques; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine

1992
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity.
    Neuron, 1992, Volume: 9, Issue:4

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Epidermal Growth Factor; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Immunoblotting; Isoenzymes; Kinetics; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine

1992
Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.
    The Journal of biological chemistry, 1992, Apr-25, Volume: 267, Issue:12

    Topics: Electrophoresis, Polyacrylamide Gel; Erythropoietin; Genistein; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Isoflavones; Leukemia, Erythroblastic, Acute; Oncogene Protein p21(ras); Phosphorylation; Proteins; ras GTPase-Activating Proteins; Recombinant Proteins; Signal Transduction; Tyrosine

1992
Activation of permeabilized HL60 cells by vanadate. Evidence for divergent signalling pathways.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: Actins; Adenosine Triphosphate; Amanitins; Calcium; Cell Membrane Permeability; Exocytosis; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Immunoblotting; Leukemia, Promyelocytic, Acute; Muramidase; NADP; Neutrophils; Oxygen Consumption; Phosphotyrosine; Polymers; Signal Transduction; Thionucleotides; Tumor Cells, Cultured; Tyrosine; Vanadates

1990
A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.
    The Journal of biological chemistry, 1990, Oct-05, Volume: 265, Issue:28

    Topics: Animals; Cell Line; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Insulin; Isoproterenol; Kinetics; Macromolecular Substances; Mice; Muscles; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Tyrosine; Virulence Factors, Bordetella

1990
The dynamic instability of microtubules is not modulated by alpha-tubulin tyrosinylation.
    Cell motility and the cytoskeleton, 1991, Volume: 20, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Brain Chemistry; Chickens; Chromatography, Affinity; Guanosine Triphosphate; Isoenzymes; Microtubule Proteins; Microtubule-Associated Proteins; Microtubules; Peptide Synthases; Tubulin; Tyrosine

1991
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation.
    Neuron, 1991, Volume: 7, Issue:6

    Topics: Animals; Carbazoles; Epidermal Growth Factor; Genistein; Guanosine Diphosphate; Guanosine Triphosphate; Indole Alkaloids; Isoflavones; Kinetics; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Tyrosine

1991
Effect of GTP gamma S on insulin binding and tyrosine phosphorylation in liver membranes and L6 muscle cells.
    The American journal of physiology, 1990, Volume: 258, Issue:1 Pt 1

    Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; Cell Membrane; Cell Membrane Permeability; Cholera Toxin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Insulin; Kinetics; Liver; Male; Muscles; NAD; Phosphorylation; Rats; Rats, Inbred Strains; Receptor, Insulin; Thionucleotides; Tyrosine

1990
Proton NMR studies of transforming and nontransforming H-ras p21 mutants.
    Biochemistry, 1990, Jan-16, Volume: 29, Issue:2

    Topics: Base Sequence; Cell Transformation, Neoplastic; DNA; Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Oncogene Protein p21(ras); Phenylalanine; Protein Conformation; Tyrosine

1990
Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src.
    Molecular and cellular biology, 1985, Volume: 5, Issue:10

    Topics: Adenosine Triphosphate; Animals; Cell Line; Chickens; Guanosine Triphosphate; Immunoglobulin G; In Vitro Techniques; Isoelectric Point; Mice; Molecular Weight; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins; Substrate Specificity; Tyrosine

1985
Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis.
    Biochemical and biophysical research communications, 1987, Nov-13, Volume: 148, Issue:3

    Topics: Aluminum; Cyclic AMP; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Lymphocyte Activation; Lymphocytes; Phosphatidylinositols; Phospholipases A; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Thionucleotides; Type C Phospholipases; Tyrosine

1987
Biochemical characterization of tyrosine kinase and phosphotyrosine phosphatase activities of HL-60 leukemia cells.
    Cancer research, 1988, Aug-01, Volume: 48, Issue:15

    Topics: Adenosine Triphosphate; Cations, Divalent; Cell Line; Ethylmaleimide; Guanosine Triphosphate; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; Peptides; Phosphoprotein Phosphatases; Phosphotyrosine; Polymers; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine

1988
Calcitonin gene related peptide (CGRP) activates adenylate cyclase of bovine aortic endothelial cells: guanosine 5' triphosphate dependence and partial agonist activity of a tyrosinated analogue.
    Cardiovascular research, 1989, Volume: 23, Issue:11

    Topics: Adenylyl Cyclases; Animals; Aorta; Calcitonin Gene-Related Peptide; Cattle; Endothelium, Vascular; Enzyme Activation; Guanosine Triphosphate; Receptors, Cell Surface; Tyrosine

1989
Guanine nucleotides induce tyrosine phosphorylation and activation of the respiratory burst in neutrophils.
    The Biochemical journal, 1989, Feb-01, Volume: 257, Issue:3

    Topics: Adenosine Triphosphate; Guanine; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Magnesium; Neutrophils; Phosphorylation; Thionucleotides; Tyrosine

1989
Modulation of the kinetic parameters of microtubule assembly by MAP-2 phosphorylation, the GTP/GDP occupancy of oligomers, and the tubulin tyrosylation status.
    Annals of the New York Academy of Sciences, 1986, Volume: 466

    Topics: Animals; Brain; Chickens; Cyclic AMP; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Phosphorylation; Tubulin; Tyrosine

1986
Inactivation of T u factor-guanosine triphosphate recognition and ribosome-binding ability by terminal oxidation-reduction of yeast phenylalanine transfer ribonucleic acid.
    The Journal of biological chemistry, 1972, Apr-10, Volume: 247, Issue:7

    Topics: Amino Acyl-tRNA Synthetases; Bacterial Proteins; Binding Sites; Borohydrides; Carbon Isotopes; Escherichia coli; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Magnesium; Osmolar Concentration; Oxidation-Reduction; Peptide Biosynthesis; Peptide Chain Elongation, Translational; Periodic Acid; Phenylalanine; Ribonucleases; Ribosomes; RNA, Bacterial; RNA, Transfer; Saccharomyces cerevisiae; Transfer RNA Aminoacylation; Tritium; Tyrosine

1972
Regulation of the enzymes of tyrosine catabolism in Tetrahymena pyriformis.
    Biochimica et biophysica acta, 1972, May-16, Volume: 264, Issue:3

    Topics: Acetates; Acetoacetates; Animals; Carbon Isotopes; Carboxy-Lyases; Enzyme Repression; Glucose; Glycogen; Guanosine Triphosphate; Homogentisic Acid; Hydrolases; Isocitrates; Isomerases; Lyases; Mixed Function Oxygenases; Oxaloacetates; Oxygenases; Phenols; Phenylpyruvic Acids; Tetrahymena pyriformis; Tyrosine; Tyrosine Transaminase

1972
Control of deoxyribonucleotide synthesis in vitro and in vivo.
    Advances in enzyme regulation, 1972, Volume: 10

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Catalysis; Cell Line; Cells, Cultured; Cricetinae; Cytosine; Deoxyribonucleotides; DNA; Escherichia coli; Guanosine Triphosphate; Hydroxyurea; Macromolecular Substances; Mice; Models, Chemical; Nucleosides; Oxidoreductases; Time Factors; Tyrosine

1972
Bovine liver glutamate dehydrogenase: tentative amino acid sequence; identification of a reactive lysine; nitration of a specific tyrosine and loss of allosteric inhibition by guanosine triphosphate.
    Proceedings of the National Academy of Sciences of the United States of America, 1970, Volume: 67, Issue:2

    Topics: Amino Acid Sequence; Animals; Cattle; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanosine Triphosphate; Liver; Lysine; Methods; Molecular Weight; Nitrates; Stereoisomerism; Tyrosine

1970
The proteins of oncogenes.
    Scientific American, 1984, Volume: 251, Issue:2

    Topics: Animals; Annexins; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Epidermal Growth Factor; ErbB Receptors; Guanosine Triphosphate; Humans; Membrane Proteins; Neoplasm Proteins; Nucleoproteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Cell Surface; Retroviridae; Tyrosine; Viral Proteins

1984
ATP is required for initiation of poliovirus RNA synthesis in vitro: demonstration of tyrosine-phosphate linkage between in vitro-synthesized RNA and genome-linked protein.
    Journal of virology, 1984, Volume: 50, Issue:2

    Topics: Adenosine Triphosphate; Carrier Proteins; Genes, Viral; Guanosine Triphosphate; HeLa Cells; Humans; Integration Host Factors; Kinetics; Nucleotidyltransferases; Poliovirus; Poly A; Poly U; RNA-Dependent RNA Polymerase; RNA, Viral; Transcription, Genetic; Tyrosine; Viral Core Proteins; Viral Proteins

1984
Resonance energy transfer between the adenosine 5'-diphosphate site of glutamate dehydrogenase and a guanosine 5'-triphosphate site containing a tyrosine labeled with 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine.
    Biochemistry, 1983, Aug-30, Volume: 22, Issue:18

    Topics: Adenosine; Adenosine Diphosphate; Affinity Labels; Animals; Cattle; Energy Transfer; Glutamate Dehydrogenase; Guanosine Triphosphate; Kinetics; Liver; Lysine; Tyrosine

1983
Isolation and identification of a tyrosyl peptide labeled by 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine at a GTP site of glutamate dehydrogenase.
    Biochemistry, 1984, Dec-18, Volume: 23, Issue:26

    Topics: Adenosine; Allosteric Site; Animals; Cattle; Glutamate Dehydrogenase; Guanosine Triphosphate; Liver; Peptides; Tyrosine

1984
X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
    Journal of molecular biology, 1995, Oct-13, Volume: 253, Issue:1

    Topics: Amino Acid Sequence; Computer Simulation; Crystallography, X-Ray; Fluorescence; GTP Phosphohydrolases; Guanosine Triphosphate; Hydrolysis; Molecular Sequence Data; Oncogene Protein p21(ras); ortho-Aminobenzoates; Protein Structure, Secondary; Stereoisomerism; Thionucleotides; Tyrosine

1995
The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.
    Molecular pharmacology, 1994, Volume: 45, Issue:4

    Topics: Calcium; Cell Membrane; Enzyme Activation; Glucuronidase; Glycerophospholipids; GTP-Binding Proteins; Guanosine Triphosphate; Histamine; Histamine Agonists; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositols; Phosphotyrosine; Receptors, Histamine H1; Respiratory Burst; Superoxides; Tumor Cells, Cultured; Tyrosine; Virulence Factors, Bordetella

1994
Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.
    Blood, 1994, Sep-15, Volume: 84, Issue:6

    Topics: Benzoquinones; Cell Differentiation; Dexamethasone; Enzyme Activation; Granulocytes; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Monocytes; Mutation; Oncogene Protein p21(ras); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinones; ras GTPase-Activating Proteins; Rifabutin; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured; Tyrosine

1994
Involvement of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing. A new method for purifying the protein and characterization of physical and enzymatic properties pertinent to splicing.
    Biochemistry, 1995, Jan-31, Volume: 34, Issue:4

    Topics: Cloning, Molecular; Guanosine Triphosphate; Introns; Kinetics; Mitochondria; Neurospora crassa; Recombinant Proteins; RNA; RNA Splicing; RNA, Mitochondrial; RNA, Transfer; Tyrosine; Tyrosine-tRNA Ligase

1995
Angiotensin II AT2 receptors are functionally coupled to protein tyrosine dephosphorylation in N1E-115 neuroblastoma cells.
    The Biochemical journal, 1995, Feb-15, Volume: 306 ( Pt 1)

    Topics: Animals; Base Sequence; Cloning, Molecular; Dithiothreitol; DNA, Complementary; Gene Expression; Guanosine Triphosphate; Mice; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Angiotensin; Transfection; Tumor Cells, Cultured; Tyrosine

1995
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Feb-15, Volume: 90, Issue:4

    Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella

1993
Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.
    Oncogene, 1993, Volume: 8, Issue:4

    Topics: Animals; Cell Line; DNA; DNA-Binding Proteins; Gene Expression; Genes, src; Growth Substances; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; In Vitro Techniques; Mice; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; ras-GRF1; Repressor Proteins; RNA-Binding Proteins; Tyrosine

1993
Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.
    Endocrinology, 1993, Volume: 133, Issue:1

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Ethers, Cyclic; Gene Expression; Genes, fos; Glycosylation; Guanosine Triphosphate; Insulin; Nerve Growth Factors; Okadaic Acid; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins p21(ras); Rats; Receptor, Insulin; Signal Transduction; Tyrosine

1993
A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
    The Journal of biological chemistry, 1994, Dec-30, Volume: 269, Issue:52

    Topics: Adaptor Proteins, Signal Transducing; Animals; CHO Cells; Cricetinae; GRB2 Adaptor Protein; Guanosine Triphosphate; Insulin Receptor Substrate Proteins; Mitogen-Activated Protein Kinase 1; Mutation; Oncogene Protein p21(ras); Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Receptor, Insulin; Tyrosine

1994
Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.
    Journal of immunology (Baltimore, Md. : 1950), 1994, Mar-01, Volume: 152, Issue:5

    Topics: Animals; B-Lymphocytes; Cell Cycle Proteins; Cell Line; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Mice; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; ras Guanine Nucleotide Exchange Factors; Receptors, Antigen, T-Cell; Tyrosine

1994
Conformational differences between complexes of elongation factor Tu studied 19F-NMR spectroscopy.
    European journal of biochemistry, 1993, Dec-15, Volume: 218, Issue:3

    Topics: Aurodox; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Magnetic Resonance Spectroscopy; Peptide Elongation Factor Tu; Peptide Elongation Factors; Protein Conformation; Tyrosine; X-Ray Diffraction

1993
Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes.
    Science (New York, N.Y.), 1993, Jun-25, Volume: 260, Issue:5116

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; GRB2 Adaptor Protein; Guanosine Triphosphate; Insulin; Insulin Receptor Substrate Proteins; Membrane Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases; Proteins; Proto-Oncogene Proteins p21(ras); Receptor, Insulin; Signal Transduction; Son of Sevenless Proteins; Transfection; Tyrosine

1993
Glutamine 170 to tyrosine substitution in yeast mitochondrial F1 beta-subunit increases catalytic site interaction with GDP and IDP and produces negative cooperativity of GTP and ITP hydrolysis.
    The Journal of biological chemistry, 1993, Oct-05, Volume: 268, Issue:28

    Topics: Azides; Bicarbonates; Catalysis; Enzyme Activation; Glutamine; GTP Phosphohydrolases; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Inosine Diphosphate; Inosine Nucleotides; Inosine Triphosphatase; Inosine Triphosphate; Mitochondria; Proton-Translocating ATPases; Pyrophosphatases; Schizosaccharomyces; Tyrosine

1993
T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Oct-15, Volume: 151, Issue:8

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Calcium; CD28 Antigens; CD3 Complex; Cell Line; Guanosine Triphosphate; Humans; Interleukin-2; Lymphocyte Activation; Molecular Sequence Data; T-Lymphocytes; Tyrosine; Wiskott-Aldrich Syndrome

1993
Rapid activation of mitogen-activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1995, Volume: 6, Issue:10

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Enzyme Inhibitors; Genistein; Guanosine Triphosphate; Interleukin-2; Isoflavones; Lymph Nodes; Lymphoma, T-Cell; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine

1995
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.
    The Journal of biological chemistry, 1997, Feb-14, Volume: 272, Issue:7

    Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; COS Cells; Guanosine Triphosphate; Oncogene Protein p21(ras); Oncogene Protein pp60(v-src); Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tyrosine

1997
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.
    Molecular and cellular biology, 1997, Volume: 17, Issue:4

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; DNA-Binding Proteins; Enzyme Activation; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Mice; Mice, Knockout; Nuclear Proteins; Oncogenes; Phosphoproteins; Phosphorylation; Proteins; ras GTPase-Activating Proteins; ras Proteins; ras-GRF1; Repressor Proteins; Signal Transduction; Transformation, Genetic; Tyrosine

1997
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
    Molecular and cellular biology, 1998, Volume: 18, Issue:4

    Topics: Androstadienes; Cell Movement; Chromones; Cytoplasm; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; ras Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin

1998
Comparison of the signal transduction pathways activated by gastrin in enterochromaffin-like and parietal cells.
    Gastroenterology, 1998, Volume: 115, Issue:1

    Topics: Animals; Enterochromaffin Cells; Gastric Acid; Gastrins; Guanosine Triphosphate; Histamine Release; Male; Muridae; Parietal Cells, Gastric; Phosphorylation; ras Proteins; Signal Transduction; Tyrosine

1998
Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex.
    Biochemistry, 1998, Oct-06, Volume: 37, Issue:40

    Topics: Fluorescent Dyes; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; ortho-Aminobenzoates; Peptide Fragments; Protein Binding; Proto-Oncogene Proteins c-raf; ras Proteins; Spectrometry, Fluorescence; Temperature; Tryptophan; Tyrosine

1998
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.
    Oncogene, 1998, Sep-24, Volume: 17, Issue:12

    Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression Regulation; Guanosine Triphosphate; Molecular Sequence Data; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Tyrosine

1998
Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitization of smooth muscle of rabbit mesenteric artery.
    British journal of pharmacology, 1998, Volume: 125, Issue:8

    Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Carcinogens; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; rho GTP-Binding Proteins; Ribose; Staurosporine; Tyrosine; Tyrphostins; Vasoconstrictor Agents

1998
Defects of tyrosine289phenylalanine mutation on binding and functional properties of the human tachykinin NK2 receptor stably expressed in chinese hamster ovary cells.
    Biochemical pharmacology, 1999, Apr-15, Volume: 57, Issue:8

    Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanosine Triphosphate; Humans; Inositol 1,4,5-Trisphosphate; Neurokinin A; Phenoxybenzamine; Phenylalanine; Point Mutation; Receptors, Neurokinin-2; Signal Transduction; Substance P; Tachykinins; Transfection; Tyrosine

1999
Identification of residues of Escherichia coli phosphofructokinase that contribute to nucleotide binding and specificity.
    Biochemistry, 1999, Apr-06, Volume: 38, Issue:14

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Arginine; Binding Sites; Cytidine Triphosphate; Escherichia coli; Guanosine Triphosphate; Inosine Triphosphate; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Phosphofructokinase-1; Substrate Specificity; Tyrosine; Uridine Triphosphate

1999
Inhibition of GTP binding to Rac2 by peroxynitrite: potential role for tyrosine modification.
    Free radical biology & medicine, 1999, Volume: 26, Issue:9-10

    Topics: Animals; Binding Sites; Fluorescent Dyes; Free Radicals; GTP-Binding Proteins; Guanosine Triphosphate; In Vitro Techniques; Nitrates; Oxidants; rac GTP-Binding Proteins; Reactive Oxygen Species; Recombinant Proteins; Tyrosine

1999
SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.
    Oncogene, 1999, Jun-24, Volume: 18, Issue:25

    Topics: Amino Acid Sequence; Animals; Becaplermin; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Enzyme Activation; Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-sis; ras Proteins; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Swine; Transfection; Tyrosine

1999
Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.
    The Journal of biological chemistry, 1999, Nov-26, Volume: 274, Issue:48

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Compartmentation; Cells, Cultured; Endocytosis; ErbB Receptors; Fibroblasts; Flavonoids; Guanosine Diphosphate; Guanosine Triphosphate; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Models, Biological; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine

1999
High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Dec-01, Volume: 163, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Compartmentation; Cell Membrane; GRB2 Adaptor Protein; Guanosine Diphosphate; Guanosine Triphosphate; Humans; NADPH Oxidases; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; ras Proteins; Receptors, IgG; Shc Signaling Adaptor Proteins; Signal Transduction; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; src-Family Kinases; Tyrosine; U937 Cells; Ubiquitin-Protein Ligases

1999
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
    The Biochemical journal, 2000, Oct-15, Volume: 351 Pt 2

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinase II; Cations; Chromatography, Agarose; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Genistein; Guanosine Triphosphate; Humans; Magnesium; Manganese; Medulloblastoma; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phosphates; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Threonine; Tumor Cells, Cultured; Tyrosine; Tyrphostins

2000
Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments.
    Journal of neurochemistry, 2000, Volume: 75, Issue:5

    Topics: Animals; Antigen-Antibody Complex; Binding Sites; Cattle; Cell Membrane; Eye Proteins; Guanosine Triphosphate; Peptide Fragments; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Rats; Retina; Rod Cell Outer Segment; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization; src-Family Kinases; Transducin; Trypsin; Tyrosine

2000
Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox.
    The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20

    Topics: Anti-Bacterial Agents; Aurodox; Binding Sites; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Leucine; Models, Molecular; Molecular Conformation; Peptide Elongation Factor Tu; Protein Binding; Protein Conformation; Recombinant Proteins; Thermus thermophilus; Tyrosine

2001
Cross talk between beta-adrenergic and bradykinin B(2) receptors results in cooperative regulation of cyclic AMP accumulation and mitogen-activated protein kinase activity.
    Molecular and cellular biology, 2001, Volume: 21, Issue:24

    Topics: Affinity Labels; Animals; Azides; COS Cells; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Guanosine Triphosphate; Immunohistochemistry; Isoproterenol; MAP Kinase Signaling System; Models, Biological; Phosphatidylinositols; Phosphorylation; Protein Binding; Receptors, Adrenergic, beta; Receptors, Bradykinin; Time Factors; Transcriptional Activation; Transfection; Tyrosine

2001
Bacteriophage phi 6 RNA-dependent RNA polymerase: molecular details of initiating nucleic acid synthesis without primer.
    The Journal of biological chemistry, 2002, May-10, Volume: 277, Issue:19

    Topics: Bacteriophage phi 6; Base Sequence; Crystallography, X-Ray; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Guanosine Triphosphate; Kinetics; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Ribonuclease, Pancreatic; RNA; RNA-Dependent RNA Polymerase; Tyrosine

2002
Critical role for Gab2 in transformation by BCR/ABL.
    Cancer cell, 2002, Volume: 1, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Benzamides; Cell Division; Cell Movement; Cell Transformation, Neoplastic; Erythroid Precursor Cells; Fusion Proteins, bcr-abl; GRB2 Adaptor Protein; Guanosine Triphosphate; Helminth Proteins; Humans; Imatinib Mesylate; Immunoblotting; Leukemia, Lymphoid; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Precipitin Tests; Proteins; Pyrimidines; Signal Transduction; Tyrosine

2002
Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.
    The EMBO journal, 2002, Sep-02, Volume: 21, Issue:17

    Topics: Amino Acid Motifs; Animals; Cell Adhesion; Cell Membrane; Cell Movement; Cell Surface Extensions; Chlorocebus aethiops; COS Cells; Cytoskeletal Proteins; Fibronectins; Guanine Nucleotide-Releasing Factor 2; Guanosine Triphosphate; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; p21-Activated Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Transport; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; rac GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Structure-Activity Relationship; Tyrosine

2002
ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5-bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes.
    Molecular biology of the cell, 2002, Volume: 13, Issue:10

    Topics: Adaptor Protein Complex 1; ADP-Ribosylation Factor 1; Amino Acid Sequence; Animals; Cattle; Cell Membrane; Clathrin-Coated Vesicles; Guanosine Triphosphate; Lipid Metabolism; Lipids; Liposomes; Molecular Sequence Data; Molecular Structure; Peptides; Phosphatidylinositol 4,5-Diphosphate; Protein Transport; Sequence Alignment; Signal Transduction; trans-Golgi Network; Tyrosine

2002
Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis.
    Biochemistry, 2002, Dec-31, Volume: 41, Issue:52

    Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Binding Sites; Catalysis; cdc42 GTP-Binding Protein; Enzyme Stability; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Tyrosine

2002
Serine 338 phosphorylation is dispensable for activation of c-Raf1.
    The Journal of biological chemistry, 2003, May-16, Volume: 278, Issue:20

    Topics: Androstadienes; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Glutathione Transferase; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; Signal Transduction; Time Factors; Tyrosine; U937 Cells; Wortmannin

2003
EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.
    Circulation research, 2003, Jul-11, Volume: 93, Issue:1

    Topics: Animals; cdc42 GTP-Binding Protein; Cell Line; Ephrin-A1; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Humans; Immunoblotting; Muscle, Smooth, Vascular; Phosphorylation; Precipitin Tests; Protein Binding; rac1 GTP-Binding Protein; Rats; Receptor, EphA4; rho GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; rhoA GTP-Binding Protein; Transfection; Tyrosine

2003
Identification of an autoinhibitory domain of p21-activated protein kinase 5.
    The Journal of biological chemistry, 2003, Sep-05, Volume: 278, Issue:36

    Topics: Amino Acid Sequence; cdc42 GTP-Binding Protein; Cell Line; Gene Deletion; Glutathione Transferase; Guanosine Triphosphate; Histidine; Humans; Leucine; Molecular Sequence Data; Mutation; p21-Activated Kinases; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Transfection; Tyrosine

2003
EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.
    Oncogene, 2003, Sep-04, Volume: 22, Issue:38

    Topics: Actins; Animals; Cell Adhesion; Cells, Cultured; COS Cells; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Guanosine Triphosphate; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-vav; Quinazolines; rac GTP-Binding Proteins; Tyrosine; Tyrphostins

2003
Inhibition of phosphatidylinositol-3-kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R- fibroblasts.
    Journal of receptor and signal transduction research, 2004, Volume: 24, Issue:1-2

    Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; GRB2 Adaptor Protein; Guanosine Triphosphate; Insulin; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; ras Proteins; Receptor, IGF Type 1; Serine; Signal Transduction; Time Factors; Tyrosine

2004
AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.
    The Journal of biological chemistry, 2004, Nov-19, Volume: 279, Issue:47

    Topics: ADP-Ribosylation Factors; Animals; Blotting, Northern; Blotting, Western; Cell Line; COS Cells; Cross-Linking Reagents; Cyclic GMP; Dimerization; DNA, Complementary; Genetic Vectors; GTPase-Activating Proteins; Guanosine Triphosphate; Guanylate Cyclase; Humans; Immunoprecipitation; Mice; Microscopy, Fluorescence; Models, Genetic; Phosphorylation; Plasmids; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Soluble Guanylyl Cyclase; src-Family Kinases; Subcellular Fractions; Tissue Distribution; Transfection; Two-Hybrid System Techniques; Tyrosine

2004
Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes.
    Molecular endocrinology (Baltimore, Md.), 2005, Volume: 19, Issue:2

    Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adenoviridae; Adipocytes; Animals; Cell Differentiation; Epidermal Growth Factor; Genetic Vectors; GRB2 Adaptor Protein; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Insulin; Ligands; MAP Kinase Signaling System; Mice; Mutation; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Platelet-Derived Growth Factor; Proline; Protein Binding; Protein Structure, Tertiary; ras GTPase-Activating Proteins; ras Proteins; Rats; Signal Transduction; Swine; Time Factors; Transfection; Tyrosine

2005
Inactivation and activation of Ras by the neurotrophin receptor p75.
    The European journal of neuroscience, 2004, Volume: 20, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Cell Line; Cells, Cultured; Dogs; Guanosine Diphosphate; Guanosine Triphosphate; Nerve Growth Factor; Neurites; Neurons; Phosphorylation; Protein Binding; Protein Structure, Tertiary; ras Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; rho GTP-Binding Proteins; Tyrosine

2004
Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells.
    Experimental oncology, 2005, Volume: 27, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Benzoquinones; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Erythroid Cells; Glutathione Transferase; GRB2 Adaptor Protein; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Phosphorylation; Proto-Oncogene Proteins p21(ras); Quinones; Rifabutin; Signal Transduction; Tyrosine

2005
Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
    Free radical biology & medicine, 2005, Sep-01, Volume: 39, Issue:5

    Topics: Annexin A5; Apoptosis; Blotting, Western; Calcium; Cell Line, Tumor; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Flavonoids; Flow Cytometry; Free Radicals; Guanosine Triphosphate; Humans; Membrane Potentials; Mitochondria; Models, Biological; Neurons; Nitric Oxide; Oxidopamine; Oxygen; Parkinson Disease; Phenols; Polyphenols; Quinones; Reactive Oxygen Species; Tea; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine

2005
GTP cyclohydrolase II structure and mechanism.
    The Journal of biological chemistry, 2005, Nov-04, Volume: 280, Issue:44

    Topics: Binding Sites; Crystallization; Crystallography, X-Ray; Escherichia coli; GTP Cyclohydrolase; Guanosine Triphosphate; Molecular Structure; Protein Conformation; Tyrosine; Zinc

2005
A Cdc42 mutant specifically activated by intersectin.
    Biochemistry, 2005, Oct-11, Volume: 44, Issue:40

    Topics: Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Catalysis; cdc42 GTP-Binding Protein; Crystallography, X-Ray; Cytoskeleton; DNA, Complementary; Green Fluorescent Proteins; Guanine; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; HeLa Cells; Humans; Kinetics; Mice; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutation; Plasmids; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Proto-Oncogene Proteins c-vav; rho GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Surface Plasmon Resonance; Time Factors; Tyrosine

2005
Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.
    The Journal of biological chemistry, 2006, Jan-13, Volume: 281, Issue:2

    Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cattle; Cell Line, Tumor; Cell Proliferation; Densitometry; Flavonoids; Growth Hormone; Guanosine Triphosphate; Immunoblotting; Immunoprecipitation; Insulin; Liver; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Time Factors; Tyrosine

2006
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
    Biochemical and biophysical research communications, 2006, Mar-10, Volume: 341, Issue:2

    Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays

2006
Modulation of subfamily B/R4 RGS protein function by 14-3-3 proteins.
    Cellular signalling, 2006, Volume: 18, Issue:12

    Topics: 14-3-3 Proteins; Binding Sites; Binding, Competitive; Cell Extracts; Cell Line; Glutathione Transferase; Green Fluorescent Proteins; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Immunoblotting; Kinetics; Leucine; Microscopy, Confocal; Protein Binding; Protein Isoforms; Recombinant Fusion Proteins; RGS Proteins; Transfection; Tyrosine

2006
Mechanism of allosteric regulation of transglutaminase 2 by GTP.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-26, Volume: 103, Issue:52

    Topics: Allosteric Regulation; Animals; Arginine; Binding Sites; Cysteine; Disulfides; GTP-Binding Proteins; Guanosine Triphosphate; Hydrogen Bonding; Models, Molecular; Mutation; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Protein Structure, Tertiary; Rats; Transglutaminases; Tyrosine; Water

2006
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
    Circulation, 2007, Aug-21, Volume: 116, Issue:8

    Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; GTP Cyclohydrolase; Guanosine Triphosphate; Leupeptins; Mice; Mice, Inbred C57BL; Nitrogen; Organ Culture Techniques; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species; Spin Labels; Tyrosine; Ubiquitin; Umbilical Veins

2007
Binding of cargo sorting signals to AP-1 enhances its association with ADP ribosylation factor 1-GTP.
    The Journal of cell biology, 2008, Feb-11, Volume: 180, Issue:3

    Topics: ADP-Ribosylation Factor 1; Animals; Binding Sites; Cattle; Clathrin; Clathrin-Coated Vesicles; Guanosine Triphosphate; Humans; Leucine; Polymers; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Signal Transduction; Subcellular Fractions; Transcription Factor AP-1; Transport Vesicles; Tyrosine

2008
Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate.
    The FEBS journal, 2008, Volume: 275, Issue:23

    Topics: Amino Acid Substitution; Anions; Carboxy-Lyases; Catalysis; Catalytic Domain; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrogen Bonding; Kinetics; Manganese; Models, Molecular; Oxaloacetic Acid; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Kinase; Tyrosine

2008
Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.
    Toxicology and applied pharmacology, 2009, Oct-15, Volume: 240, Issue:2

    Topics: Animals; Cattle; Chlorpyrifos; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Guanosine Triphosphate; Microscopy, Atomic Force; Nanostructures; Neurotoxicity Syndromes; Protein Multimerization; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tubulin; Tubulin Modulators; Tyrosine

2009
Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.
    The Journal of biological chemistry, 2010, Jun-04, Volume: 285, Issue:23

    Topics: Amino Acid Sequence; Animals; Glutamine; Guanosine Triphosphate; Guanylate Cyclase; Heme; Kinetics; Molecular Sequence Data; Nitric Oxide; Oxygen; Porphyrins; Protein Binding; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase; Spectrophotometry; Tyrosine

2010
Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.
    Molecular and cellular biology, 2010, Volume: 30, Issue:17

    Topics: Animals; Cell Line; Cell Membrane; Epithelial Cells; Guanosine Triphosphate; Humans; p21-Activated Kinases; Phosphorylation; Protein Transport; rho GTP-Binding Proteins; Serum; src-Family Kinases; Tyrosine

2010
Tyr39 of ran preserves the Ran.GTP gradient by inhibiting GTP hydrolysis.
    Journal of molecular biology, 2010, Aug-06, Volume: 401, Issue:1

    Topics: Adsorption; Animals; Catalytic Domain; Eukaryotic Cells; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Models, Biological; Models, Molecular; Protein Conformation; Protein Transport; ran GTP-Binding Protein; Tyrosine

2010
EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR.
    Molecular biology of the cell, 2012, Volume: 23, Issue:7

    Topics: Amino Acid Substitution; Bacterial Outer Membrane Proteins; Binding Sites; Down-Regulation; Endosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Escherichia coli Proteins; Feedback, Physiological; Guanosine Triphosphate; HeLa Cells; Humans; Movement; Mutagenesis; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; RNA; Sequence Deletion; Tyrosine

2012
The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations.
    Biophysical journal, 2012, Jul-18, Volume: 103, Issue:2

    Topics: Biocatalysis; GTPase-Activating Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Magnesium; Molecular Conformation; Molecular Dynamics Simulation; Quantum Theory; ras Proteins; Tyrosine; Vibration; Water

2012
Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2''-phosphotransferase IIa.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8

    Topics: Adenosine Triphosphate; Amino Acid Substitution; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Escherichia coli; Genes, Bacterial; Genetic Vectors; Guanosine Triphosphate; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Phosphotransferases (Alcohol Group Acceptor); Protein Structure, Secondary; Substrate Specificity; Tyrosine

2013
The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.
    The Journal of biological chemistry, 2013, Aug-16, Volume: 288, Issue:33

    Topics: Amino Acid Sequence; Bacterial Proteins; Biocatalysis; Crystallography, X-Ray; Enzyme Activation; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Kinetics; Legionella pneumophila; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; rab GTP-Binding Proteins; Sequence Alignment; Static Electricity; Structure-Activity Relationship; Tyrosine

2013
DNA catalysts with tyrosine kinase activity.
    Journal of the American Chemical Society, 2013, Oct-09, Volume: 135, Issue:40

    Topics: DNA, Catalytic; Guanosine Triphosphate; Oligonucleotides; Phosphorylation; Protein-Tyrosine Kinases; RNA; Tyrosine

2013
Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy.
    The Journal of biological chemistry, 2015, Oct-02, Volume: 290, Issue:40

    Topics: Catalysis; Catalytic Domain; Crystallography, X-Ray; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Magnesium; Manganese; Membrane Proteins; Molecular Dynamics Simulation; Mutation; Phosphates; Protein Binding; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Tyrosine

2015
Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis.
    Scientific reports, 2016, Jan-28, Volume: 6

    Topics: Adenosine Monophosphate; Guanosine Triphosphate; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Stability; rab1 GTP-Binding Proteins; Static Electricity; Tyrosine

2016
Dopamine induces lipid accumulation, NADPH oxidase-related oxidative stress, and a proinflammatory status of the plasma membrane in H9c2 cells.
    American journal of physiology. Heart and circulatory physiology, 2016, 11-01, Volume: 311, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caspase 3; Cell Line; Cell Membrane; Cell Survival; Dopamine; Dopamine Agents; Flow Cytometry; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Inflammation; Lipid Metabolism; Microscopy, Electron; Microscopy, Fluorescence; Myoblasts, Cardiac; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Nuclear Proteins; Oxidative Stress; Peroxidase; Rats; Reactive Oxygen Species; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Tyrosine

2016
Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.
    The Journal of biological chemistry, 2017, 04-28, Volume: 292, Issue:17

    Topics: Animals; Autophagy; Cell Membrane; Chromatography; Fluorescence Resonance Energy Transfer; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; HEK293 Cells; HeLa Cells; Humans; Immunoprecipitation; Mice; Microscopy, Fluorescence; Mutation; Phosphorylation; Protein Binding; Protein Domains; rab GTP-Binding Proteins; Tyrosine

2017
Halogenation of tyrosine perturbs large-scale protein self-organization.
    Nature communications, 2022, 08-17, Volume: 13, Issue:1

    Topics: Bacterial Proteins; Cytoskeletal Proteins; Guanosine Triphosphate; Halogenation; Protein Binding; Tyrosine

2022
Microtubule detyrosination by VASH1/SVBP is regulated by the conformational state of tubulin in the lattice.
    Current biology : CB, 2023, 10-09, Volume: 33, Issue:19

    Topics: Guanosine Triphosphate; Microtubules; Paclitaxel; Tubulin; Tyrosine

2023