tyrosine has been researched along with epidermal growth factor in 668 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (11.53) | 18.7374 |
| 1990's | 343 (51.35) | 18.2507 |
| 2000's | 194 (29.04) | 29.6817 |
| 2010's | 45 (6.74) | 24.3611 |
| 2020's | 9 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Honda, Y; Iwaki, M; Kuriyama, S; Yoshimura, N | 1 |
| Andersson, A; Capala, J; Carlsson, J | 1 |
| Maa, MC; Moyers, JS; Parsons, JT; Parsons, SJ; Vines, RR; Wilson, LK | 1 |
| Liu, J; Piotrowski, J; Slomiany, A; Slomiany, BL | 1 |
| Liu, J; Slomiany, A; Slomiany, BL | 1 |
| Knapp, AM; Knüchel, R; Mansbridge, JN; Sutherland, RM | 1 |
| Countaway, JL; Davis, RJ; Nairn, AC | 1 |
| Her, JH; L'Allemain, G; Sturgill, TW; Weber, MJ; Wu, J | 1 |
| Bassel-Duby, R; Bittick, T; Gething, MJ; Jiang, NY; Madison, E; McGookey, D; Orth, K; Sambrook, J; Shohet, R | 1 |
| Carpenter, G; Jones, GA; Nishibe, S; Rhee, SG; Wahl, MI | 1 |
| Gotoh, N; Hino, M; Shibuya, M; Tojo, A; Yazaki, Y | 1 |
| Church, JG; Lockwood, AG; Richardson, VJ | 1 |
| Fekete, Z; Liu, J; Murty, VL; Slomiany, A; Slomiany, BL | 1 |
| Bertuzzi, G; Chamak, B; Girault, JA; Greengard, P; Pang, DT; Tixier, H; Wang, JK | 1 |
| Portnoy, DA; Smith, GA | 1 |
| Anderson, NG | 1 |
| Davis, RJ; Latour, DA; Raden, DL; Stanley, K; Theroux, SJ | 1 |
| Lukas, TJ; Staros, JV; Woltjer, RL | 1 |
| Hunter, T; Krieg, J | 1 |
| Cohen, S; Donaldson, RW | 1 |
| Dy, RC; Earp, HS; Huckle, WR | 1 |
| Dunn, WA; Fischer, JE; Humphreys-Beher, MG; Nakagawa, Y; Purushotham, KR; Schneyer, CA; Wang, PL | 1 |
| Green, SH; Qui, MS | 1 |
| Decker, SJ; Ohmichi, M; Saltiel, AR | 1 |
| Bradshaw, RA; Raffioni, S | 2 |
| Faúndez, V; Garrido, J; González, A; Holuigue, L; Krauss, R | 1 |
| Garrison, JC; Liang, M | 1 |
| Hunter, T; Meisenhelder, J | 1 |
| Goldkorn, T; Mendelsohn, J | 1 |
| Makgoba, MW; Pillay, TS | 1 |
| Felder, S; Millauer, B; Schlessinger, J; Seedorf, K; Ullrich, A | 1 |
| Campos-González, R; Glenney, JR | 2 |
| Kamer, AR; Lee, MT; Liebow, C; Schally, AV | 1 |
| Bird, TA; Saklatvala, J | 1 |
| Friedman, B; Fujiki, H; Rosner, MR | 1 |
| Carpenter, G; Kim, H; Kim, JW; Nishibe, S; Rhee, SG; Wahl, MI | 1 |
| Brock, T; Kahn, CR; Karasik, A; Pepinsky, RB; Reddy, SS | 1 |
| Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
| Kohno, M; Nishizawa, N; Nomoto, H; Tsujimoto, M | 1 |
| Clinton, GM; Li, SW; Lin, YZ | 1 |
| Akanuma, Y; Kasuga, M; Koshio, O; Takaku, F; Tashiro-Hashimoto, Y; Tobe, K | 1 |
| Earp, HS; McCune, BK; Prokop, CA | 1 |
| Kudryavtseva, NV; Nikolsky, NN; Reshetnikova, GF; Sorokin, AB | 1 |
| Iwashita, S; Mitsui, K | 1 |
| Nesterov, A; Nikolsky, N; Reshetnikova, G; Vinogradova, N | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Jeffs, RA; Outlaw, HE; Rhee, SG | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Rhee, SG | 1 |
| Nesterov, AM; Nikol'skiĭ, NN; Reshetnikova, GF; Sorkin, AD; Vinogradova, NA | 1 |
| Carpenter, G; Hernández-Sotomayor, SM; Nishibe, S; Rhee, SG; Tonks, NK; Wahl, MI | 1 |
| Dy, RC; Earp, S; Herman, B; Huckle, WR; Prokop, CA | 1 |
| Parsons, SJ; Wilson, LK | 1 |
| Ascoli, M; Miller, ES | 1 |
| Hirai, M; Shimizu, N | 2 |
| Fitzgerald, DL; Payne, DM; Wasilenko, WJ; Weber, MJ | 1 |
| Ballou, LM; Luther, H; Thomas, G | 1 |
| Gansbacher, B; Gilboa, E; Hershberg, R; Oval, J; Schlessinger, J; Taetle, R | 1 |
| Contreras, ML; Fink, D; Guroff, G; Kim, HS; Kim, UH; Park, DJ; Rhee, SG | 1 |
| Bouton, AH; Gibbs, JB; Kanner, SB; Parsons, JT; Vines, RR; Wang, HC | 1 |
| Fischer, R; Kashles, O; Schlessinger, J; Ullrich, A; Yarden, Y | 1 |
| Anderson, D; Ellis, C; Koch, CA; Moran, MF; Pawson, T | 1 |
| Chomsky, O; Dvir, A; Gazit, A; Gilon, C; Levitzki, A; Milner, Y | 1 |
| Abdel-Ghany, M; Koland, J; Racker, E; Revis-Gupta, S | 1 |
| Budnik, LT; Mukhopadhyay, AK | 1 |
| Beguinot, L; Helin, K; Magni, M; Meldolesi, J; Pandiella, A | 1 |
| Iizuka, Y; Iwashita, S; Nishiya, S; Takatori, T; Takayama, Y; Tsuruo, T; Yamazaki, A; Yamori, T | 1 |
| Frackelton, AR; Kannan, B; Mermelstein, F; Posner, M | 1 |
| Anderson, NG; Erickson, AK; Ray, LB; Sturgill, TW | 1 |
| Dey, SK; Paria, BC; Tsukamura, H | 1 |
| Chu, SH; Walker, WA | 1 |
| Kornilova, ES; Nesterov, AM; Nikol'skiĭ, NN; Vdovina, IB | 1 |
| Dilts, CA; Ethier, SP; Moorthy, R | 1 |
| Hall, FL; Horcher, PG; Seth, R; Shum, L; Slavkin, HC; Warburton, D; Werb, Z | 1 |
| Alexander, C; Decker, SJ; Habib, T | 1 |
| Green, SH; Qiu, MS | 1 |
| L'Allemain, G; Pouyssegur, J; Weber, MJ | 1 |
| Kessler, TL; Markus, G | 1 |
| Ishihara, S; Mizuno, M; Taketani, Y | 1 |
| Hsu, CY; Hurwitz, DR; Mervic, M; Zilberstein, A | 1 |
| Goldschmidt-Clermont, PJ; Kim, JW; Machesky, LM; Pollard, TD; Rhee, SG | 1 |
| Miyasaka, J; Miyasaka, T; Saltiel, AR; Sherline, P; Sternberg, DW | 1 |
| Downing, JR; Reynolds, AB | 1 |
| Dressler, KA; Goldkorn, T; Kolesnick, RN; Liotta, D; Menaldino, D; Mendelsohn, J; Muindi, J; Radin, NS | 1 |
| Campbell, ID; Dudgeon, TJ; Edwards, RM; Fallon, A; Hommel, U | 1 |
| Chandrasekar, B; Korc, M; Shah, GN | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Hirai, M; Kobayashi, M; Shimizu, N | 1 |
| Engler, DA; Montelione, GT; Niyogi, SK | 1 |
| Avruch, J; Kyriakis, JM | 1 |
| Hamanaka, R; Hirai, R; Kohno, K; Kuratomi, Y; Kuwano, M; Mizoguchi, H; Ono, M | 1 |
| Cohen, S; Sawyer, ST | 1 |
| Evans, RM; Gamou, S; Gill, GN; Lin, C; Rosenfeld, MG; Shimizu, N; Thompson, DM; Weber, W | 1 |
| Landreth, GE; Rieser, GD; Williams, LK | 1 |
| Damsky, C; Hwang, F; Phillips, PD; Ross, AH; Vance, P | 1 |
| Hollenberg, MD; Pallen, CJ; Valentine, KA; Wang, JH | 1 |
| Bremer, EG; Hakomori, S; Schlessinger, J | 1 |
| MacLeod, CL; Magun, BE; Mendelsohn, J; Sunada, H | 1 |
| Bass, G; Wedner, HJ | 1 |
| Kadowaki, T; Kasuga, M; Koyasu, S; Nishida, E; Sakai, H; Takaku, F; Tobe, K; Toyoshima, K; Yahara, I; Yamamoto, T | 1 |
| Izumi, T; Kadowaki, T; Kasuga, M; Koyasu, S; Nishida, E; Sakai, H; Takaku, F; Tobe, K; Yahara, I | 1 |
| David-Pfeuty, T; Guesdon, F | 1 |
| Ek, B; Ekman, P; Engström, L | 1 |
| Carpentier, JL; Kahn, RC; Orci, L; White, MF | 1 |
| Chen, WS; Gill, GN; Glenney, JR; Lazar, CS; Rosenfeld, MG; Walton, GM; Zokas, LM | 1 |
| Carpenter, G; Daniel, TO; Wahl, MI | 1 |
| Maher, PA | 1 |
| Casnellie, JE; Hinkle, PM; Kaji, H | 1 |
| Kahn, CR; Karasik, A | 1 |
| Antoniades, HN; Graves, DT | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Carpenter, G; Nishibe, S; Rhee, SG; Suh, PG; Wahl, MI | 1 |
| Decker, SJ; Harris, P | 1 |
| Felder, S; Levitzki, A; Lyall, R; Margolis, B; Mervic, M; Rhee, SG; Schlessinger, J; Ullrich, A; Zilberstein, A | 1 |
| Ackerman, P; Osheroff, N | 1 |
| Hammacher, A; Heldin, CH; Nistér, M | 1 |
| Arai, K; Collins, M; Miyajima, A; Wang, HM | 1 |
| Koyasu, S; Miyata, Y; Nishida, E; Sakai, H; Yahara, I | 1 |
| Aoyagi, T; Kato, N; Kobayashi, H; Miura, Y; Nemoto, O; Suya, H; Umeda, K | 1 |
| Ballotti, R; Dull, T; Lammers, R; Schlessinger, J; Scimeca, JC; Ullrich, A; Van Obberghen, E | 1 |
| Kamińska, B | 1 |
| Alengrin, F; Ballotti, R; Honegger, AM; Obberghen, EV; Schlessinger, J; Scimeca, JC; Ullrich, A | 1 |
| Gazit, A; Gilon, C; Levitzki, A; Lyall, RM; Schlessinger, J; Zilberstein, A | 1 |
| Bellot, F; Borrello, I; Comoglio, P; King, CR; Schlessinger, J | 1 |
| Hunter, T; Isacke, CM; Trowbridge, IS | 1 |
| Cooper, JA; Hunter, T | 3 |
| Alexander, CB; Cooper, JA; Hunter, T | 1 |
| Cooper, JA; King, CS | 1 |
| Fox, CF; Rao, KV | 1 |
| Bertics, PJ; Gill, GN; Santon, JB | 1 |
| Vila, J; Weber, MJ | 1 |
| Kamps, MP; Stern, DF | 1 |
| Denton, RM; Diggle, TA; Tavaré, JM | 1 |
| De Marco, A; Kaptein, R; Mayo, KH | 1 |
| Kohno, M | 1 |
| Imazu, M; Takeda, M; Tsukamoto, H; Usui, H; Yoshikawa, K | 1 |
| Brugge, JS; Chinkers, M | 1 |
| Cohen, S; Ushiro, H | 1 |
| Blomberg, J; Reynolds, FH; Stephenson, JR; Van de Ven, WJ | 2 |
| Earp, HS; O'Keefe, EJ; Rubin, RA | 1 |
| Bornstein, P; Casnellie, JE; Gallis, B; Krebs, EG; Pike, LJ | 1 |
| Bowen-Pope, DF; Cooper, JA; Hunter, T; Raines, E; Ross, R | 1 |
| Bowen-Pope, DF; Krebs, EG; Pike, LJ; Ross, R | 1 |
| Erikson, E; Erikson, RL; Foulkes, JG; Gilmer, TM | 1 |
| Eisen, HN; Frackelton, AR; Ross, AH | 1 |
| Hapgood, J; Lax, I; Libermann, TA; Naor, Z; Schlessinger, J; Schreiber, AB; Yarden, Y | 1 |
| Cohen, S | 1 |
| Buss, JE; Chouvet, C; Gill, GN | 1 |
| Hunter, T | 1 |
| Decker, SJ | 2 |
| Buss, JE; Gill, GN; Kudlow, JE | 1 |
| Fryling, C; Reynolds, FH; Stephenson, JR; Todaro, GJ | 1 |
| Earp, HS; Rubin, RA | 1 |
| Casnellie, JE; Edelman, AM; Gallis, B; Krebs, EG | 1 |
| King, AC; Moon, SO; Palfrey, HC | 1 |
| Connors, JM; Frackelton, AR; Friedman, B; Fujiki, H; Rosner, MR; Ross, AH; Sugimura, T | 1 |
| Cobb, MH; Rosen, OM | 1 |
| Ek, B; Heldin, CH; Rönnstrand, L | 1 |
| Martinez, R; Nakamura, KD; Weber, MJ | 1 |
| Austin, KS; Dy, RC; Earp, HS; Rubin, RA | 1 |
| Baldwin, GS; House, C; Kemp, BE | 1 |
| Avruch, J; Blackshear, PJ; Nemenoff, RA; Osathanondh, R; Pierce, MW | 1 |
| Creuzet, C; Ehrhart, JC; Loeb, J; Rollet, E | 1 |
| Gillespie, JM; Marshall, RC; Moore, GP; Panaretto, BA; Robertson, DM | 1 |
| Bornstein, P; Casnellie, JE; Gallis, B; Krebs, EG; Marquardt, H; Pike, LJ; Todaro, GJ | 1 |
| Seedorf, K; Sherman, M; Ullrich, A | 1 |
| Aoto, M; Fukami, Y; Sato, A; Sato, K | 1 |
| Polk, DB | 3 |
| Darnell, JE; Gilman, MZ; Harpur, AG; Sadowski, HB; Shuai, K; Wilks, AF; Ziemiecki, A | 1 |
| Nakano, H; Ohno, H; Saito, T | 1 |
| Alexander, P; Davies, DE; Holt, SJ; Inman, CB | 1 |
| Errasfa, M; Stern, A | 2 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Ohmichi, M; Saltiel, AR; Sawada, T | 1 |
| Breitbart, H; Lax, Y; Rubinstein, S | 1 |
| Birge, RB; Fajardo, JE; Glassman, R; Hanafusa, H; Hempstead, BL; Kraemer, R; Mahadeo, D | 1 |
| Brautigan, DL; Chen, J; Parsons, S | 1 |
| Domin, J; Higgins, T; Rozengurt, E | 1 |
| Anderson, NG; Milligan, G | 1 |
| Cantley, LC; Carraway, KL; Gullick, WG; Prigent, SA; Soltoff, SP | 1 |
| Kitamura, N; Komada, M | 2 |
| Erlich, HP; Groner, JP; Heights, R; Kraemer, BA; Zamora, RL | 1 |
| Kido, Y; Kishi, K; Rokutan, K; Sakai, A; Shizuka, F; Teramoto, F | 1 |
| Izumi, H; Kohno, K; Kung, HF; Kuwano, M; Ono, M; Ushiro, S | 1 |
| Hefti, F; Isono, F; Knüsel, B; Widmer, HR | 1 |
| Bayna, EM; Cheresh, DA; Klemke, RL; Yebra, M | 1 |
| Kim, S; Li, W; Rockow, S; Xiong, W; Xu, J | 1 |
| Antoniotti, S; De Bortoli, M; Hynes, NE; Maggiora, P; Sapei, ML; Taverna, D | 1 |
| Bird, TA; Gayle, M; Kyriakis, JM; Milne, A; Tyshler, L; Virca, GD | 1 |
| Doppler, W; Garimorth, K; Philipp, S; Welte, T | 1 |
| da Silva, AM; Fries, DM; Monteiro, HP; Peranovich, TM; Stern, A | 1 |
| Ahmad, S; Hollenberg, MD; Laniyonu, A; Saifeddine, M | 1 |
| Bermudez, E; Everitt, J; Ferriola, PC; Mangum, J; Stewart, W; Walker, C | 1 |
| Doki, Y; Inoue, M; Iwazawa, T; Kadowaki, T; Matsui, S; Oka, H; Shimaya, K; Shiozaki, H; Takeichi, M; Tamura, S | 1 |
| Carpenter, G; McCollum, GW; Polk, DB | 1 |
| Beerli, RR; Graus-Porta, D; Hynes, NE | 1 |
| Alexander, W; Bohmer, RM; Danks, JA; Fowler, KJ; Hibbs, ML; Maglitto, R; Mann, GB; Nice, EC; Thumwood, C; Walker, F | 1 |
| Kelleher, D; Long, A; McDevitt, J; Murphy, A; Sheils, O | 1 |
| Hirota, K; Imai, T; Kurachi, H; Ogren, L; Talamantes, F; Yamaguchi, M | 1 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Nohara, A; Ohmichi, M; Sakamoto, Y; Zhang, ZX | 1 |
| Eling, TE; Everhart, AL; Glasgow, WC | 1 |
| Chen, K; Cohen, S; Ruff-Jamison, S | 2 |
| Adachi, T; Nakamura, T; Nakashima, S; Nozawa, Y; Saji, S | 1 |
| Cybulsky, AV; Fine, RN; Goodyer, PR; Kaskel, FJ; Lin, JJ | 1 |
| Cuveele, JF; de Witte, PA; Merlevede, WJ; Vandenheede, JR | 1 |
| Bian, L; Cao, H; Lei, ZM; Rao, CV | 1 |
| Brady, MJ; Mastick, CC; Saltiel, AR | 1 |
| Pessin, JE; Yamauchi, K | 1 |
| Anderson, JM; Balda, MS; Van Itallie, CM | 1 |
| Gawdi, G; Misra, UK; Pizzo, SV | 1 |
| Muller, WJ; Muthuswamy, SK | 1 |
| Breton, M; Gavaret, JM; Pierre, M; Pomerance, M | 1 |
| Bos, JL; Burgering, BM; Coffer, PJ; Kruijer, W; Peppelenbosch, MP | 1 |
| Bradshaw, RA; Wu, YY | 2 |
| Okada, S; Pessin, JE; Yamauchi, K | 1 |
| Ikemoto, H; Kaba, K; Miyaji, K; Nakano, A; Tani, E | 1 |
| Blumberg, D; Feinstein, SC; Radeke, MJ | 1 |
| Bando, K; Kannuki, S; Matsumoto, K; Rokutan, K; Shouno, M | 1 |
| Feldman, EL; Leventhal, PS; Randolph, AE; Schenone, A; Vesbit, TE; Windebank, A | 1 |
| Koizumi, S; Okada, N | 1 |
| Buchdunger, E; Lydon, N; Mett, H; Meyer, T; Müller, M; Regenass, U; Rösel, J; Traxler, P; Trinks, U | 1 |
| Cerione, RA; Gamett, DC; Greene, T; Kim, HH; Koland, JG; Wagreich, AR | 1 |
| Hawes, BE; Krueger, KM; Lefkowitz, RJ; Luttrell, DK; Luttrell, LM; Porfiri, E; Sakaue, M; Touhara, K; van Biesen, T | 1 |
| Batzer, AG; Dikic, I; Galisteo, ML; Langdon, WY; Schlessinger, J | 1 |
| Decker, SJ; Mayer, BJ; Saltiel, AR; Zhu, G | 1 |
| Davis, RJ; Raden, DL; Selva, E | 1 |
| Hamburger, AW; Mishra, S | 3 |
| Bos, JL; Hordijk, PL; Medema, RH; Moolenaar, WH; van Corven, EJ | 1 |
| Ploegh, HL; Schaap, D; van Blitterswijk, WJ; van der Bend, RL; van der Wal, J | 1 |
| Bombien, E; Offermanns, S; Schultz, G | 2 |
| Gilman, MZ; Sadowski, HB | 1 |
| Crouch, MF; Hendry, IA | 1 |
| Chen, K; Cohen, S; McGlade, J; Pawson, T; Ruff-Jamison, S | 1 |
| Carter, V; Parsons, M; Valentine, M | 1 |
| Bennett, W; Gerwin, BI; Harris, CC; Hui, F; Lupu, R; Murakami, M; Noguchi, M | 1 |
| Colussi, DJ; Merkel, LA; Perrone, MH; Rivera, LM | 1 |
| Ohmichi, M; Pang, L; Ribon, V; Saltiel, AR | 1 |
| Langgut, W | 1 |
| Baldassare, JJ; Elder, JT; Fisher, GJ; Henderson, PA; Reynolds, NJ; Talwar, HS; Voorhees, JJ | 1 |
| Fish, EN; Ghislain, J; Stevens, JK; Trogadis, J | 1 |
| Burova, EB; Nesterov, AM; Nikol'skiĭ, NN; Vdovina, IB | 1 |
| Berk, BC; Bernstein, KE; Delafontaine, P; Heerdt, L; Marrero, MB; Paxton, WG; Schieffer, B | 1 |
| Graves, DT; Kang, YM; Yeh, YL | 1 |
| Aruffo, A; Carlton, GW; Culouscou, JM | 1 |
| Armanini, MP; Ho, WH; Nuijens, A; Osheroff, PL; Phillips, HS | 1 |
| Draznin, B; Langlois, WJ; Leitner, JW; Olefsky, JM; Sasaoka, T | 1 |
| Nakagawa, H; Okada, M; Okumura, N | 1 |
| Davis, JS; Hildebrandt, JM; Keel, BA; May, JV | 1 |
| Auricchio, A; Bilancio, A; Castoria, G; di Domenico, M; Migliaccio, A | 1 |
| Aberle, H; Hoschuetzky, H; Kemler, R | 1 |
| Alvarez, CV; Beguinot, L; Carpenter, G; Soler, C | 1 |
| Batova, A; Creek, KE; Forand, R; MacDonald, LM; Pirisi, L; Zyzak, LL | 1 |
| Ambroso, LA; Bridges, AJ; Connors, RW; Fry, DW; Kraker, AJ; Leopold, WR; McMichael, A; Nelson, JM | 1 |
| Chen, K; Cohen, S; Darnell, JE; Ruff-Jamison, S; Wen, Z; Zhong, Z | 1 |
| Hayakawa, M; Hori, T; Ito, F; Kitamura, N; Miyazawa, K; Oku, N; Shibamoto, S; Takeichi, M; Takeuchi, K | 1 |
| Berl, T; Heasley, LE; Senkfor, SI; Strasheim, A; Teitelbaum, I; Winitz, S | 1 |
| Lamprey, RM; Stokkers, PC; Thompson, JF | 1 |
| Czajkowski, A; Piotrowski, J; Slomiany, A; Slomiany, BL; Yotsumoto, F | 1 |
| Rhee, SG; Williamson, JR; Yang, LJ | 1 |
| Darnell, JE; Wen, Z; Zhong, Z | 1 |
| Folkman, J; Igarashi, K; Nakata, M; Sasada, R; Shing, Y; Shintani, A; Watanabe, T | 1 |
| Eppenberger, U; Kueng, W; Liu, R; Loop, P; Mueller, H; Wosikowski, K | 1 |
| Cohen, ME; Donowitz, M; Montgomery, JL; Walker, MS | 1 |
| Campbell, ID; Dahlqvist, I; Drakenberg, T; Handford, P; Mayhew, M; Persson, E; Robin, M; Stenflo, J; Sunnerhagen, MS; Tilley, JW | 1 |
| Egan, SE; Goldberg, HJ; Hack, N; Skorecki, KL; Warner, LC; Weinberg, RA | 1 |
| Dye, JF; Gillespie, J; Guillou, PJ; Schachter, M | 1 |
| Hordijk, PL; Moolenaar, WH; van Corven, EJ; Verlaan, I | 1 |
| Carpenter, G; Sorkin, A | 1 |
| Brownlee, GG; Handford, P; Hughes, PE; Morgan, G; Rooney, EK | 1 |
| Levy, DE; Schindler, C; Schlessinger, J; Silvennoinen, O | 1 |
| Decker, SJ; Pang, L; Saltiel, AR | 1 |
| Erikson, E; Fridman, H; Granot, Y; Maller, JL; Schrier, RW; Van Putten, V; Williams, B | 1 |
| Grabska, M; Liu, J; Slomiany, A; Slomiany, BL | 1 |
| Czajkowski, A; Liu, J; Murty, VL; Piotrowski, J; Slomiany, A; Slomiany, BL | 1 |
| Chang, CP; Collawn, JF; Farquhar, MG; Komuro, M; Kuhn, LA; Lazar, CS; Rosenfeld, MG; Tainer, JA; Trowbridge, IS; Walsh, BJ | 1 |
| Leeb-Lundberg, F; McAllister, BS; Olson, MS | 1 |
| Darnell, JE; Gilman, MZ; Sadowski, HB; Shuai, K | 1 |
| Bos, JL; McGlade, J; Pawson, T; Pelicci, G; Pronk, GJ | 1 |
| Imoto, M; Iwami, J; Kakeya, H; Koyano, T; Matsumoto, H; Nakamura, K; Tabata, Y; Tadano, K; Umezawa, K | 1 |
| Niyogi, SK; Tadaki, DK | 1 |
| Barnes, S; Peterson, G | 1 |
| Baldwin, GS; Burgess, AW; Ji, H; Moritz, RL; Simpson, RJ; Ward, LD | 1 |
| Berryman, M; Bretscher, A; Gary, R | 1 |
| Ahn, BY; Chang, JS; Kim, HS; Lee, YH; Min, DS; Ryu, SH; Suh, PG | 1 |
| Burns, DM; Kawase, T; Ogata, S; Orikasa, M | 1 |
| Enokido, Y; Hatanaka, H; Ikeuchi, T; Yamada, M | 1 |
| Davis, RJ; Galcheva-Gargova, Z; Theroux, SJ | 1 |
| Majumdar, AP; Malecka-Panas, E; Relan, NK | 1 |
| Cantley, LC; Soltoff, SP | 1 |
| Anderson, JM; Fanning, AS; Lapierre, L; Van Itallie, CM | 1 |
| Dilts, CA; Dziubinski, ML; Ethier, SP; Pierce, LJ; Ram, TG | 1 |
| Hayakawa, M; Hori, T; Ito, F; Kitamura, N; Miyazawa, K; Shibamoto, S; Takeuchi, K | 1 |
| Cohen, BD; Fell, HP; Foy, L; Green, JM | 1 |
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| Fujioka, A; Itoh, RE; Kurokawa, K; Matsuda, M; Mayer, BJ; Sharma, A | 1 |
| Berk, BC; Yan, C; Yin, G; Zheng, Q | 1 |
| Blagoev, B; Haack-Sorensen, M; Kassem, M; Kratchmarova, I; Mann, M | 1 |
| Bae, YS; Choi, JH; Hong, WP; Kim, HS; Lee, JR; Park, JB; Ryu, SH; Suh, PG; Yun, S | 1 |
| Brunet, A; David-Dufilho, M; Millanvoye-Van Brussel, E; Rendu, F; Topal, G; Walch, L | 1 |
| Ichimatsu, D; Ito, H; Miyamoto, K; Nomura, M; Tsukada, H; Yoshida, T | 1 |
| Akishita, M; Chang, K; Eto, M; Hikasa, M; Iijima, K; Kaneki, M; Kozaki, K; Ota, H; Ouchi, Y; Tokunaga, E | 1 |
| Larocque, D; Lukong, KE; Richard, S; Tyner, AL | 1 |
| Hetey, SE; Lalonde, DP; Turner, CE | 1 |
| Caldelari, R; Getsios, S; Godsel, LM; Green, KJ; Kowalczyk, AP; Müller, EJ; Yin, T | 1 |
| Hoffmann, KM; Jensen, RT; Tapia, JA | 1 |
| Chen, YR; Chen, YT; Fu, YN; Hu, SF; Huang, SF; Lin, CH; Tsai, SF; Yang, ST | 1 |
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| Hovens, CM; I, ST; Lock, P; Schieb, H; Straffon, AF; Stylli, SS | 1 |
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| Auricchio, F; Bottero, D; Castoria, G; Ciociola, A; De Falco, A; De Stasio, R; Di Domenico, M; Lombardi, M; Migliaccio, A; Nanayakkara, M; Varricchio, L | 1 |
| Apodaca, G; Balestreire, EM | 1 |
| Brunton, VG; Frame, MC; Harrington, K; Hooper, S; Macpherson, IR; McGarry, L; Ozanne, BW; Sahai, E; Serrels, A | 1 |
| Jia, Q; Jia, Z; Liang, H; Liu, B; Zhang, H; Zhao, Z | 1 |
| Hautaniemi, S; Lauffenburger, DA; White, FM; Wolf-Yadlin, A | 1 |
| Furukawa, M; Goya, S; Greene, MI; Kawase, I; Kijima, T; Kumagai, T; Matsuoka, H; Nagatomo, I; Osaki, T; Tachibana, I; Takahashi, R; Takeda, Y; Yamadori, T; Yoneda, T; Yoshida, M; Yoshimura, M | 1 |
| Aggarwal, BB; Ahn, KS; Chaturvedi, MM; Sethi, G | 1 |
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| Anderson, RA; Ling, K; Sun, Y; Wagoner, MP | 1 |
| Dorosh, VN; Grudinkin, PS; Kropotov, AV; Nikolsky, NN; Zenin, VV | 1 |
| Fereshteh, M; Lahusen, T; Oh, A; Riegel, AT; Wellstein, A | 1 |
| Bhattacharya, S; Johnson, LR; Ray, RM | 1 |
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| Childress, C; Lin, Q; Shen, F; Yang, W | 1 |
| Bhat, HK; Ganju, RK; McHugh, K; Paruchuri, V; Polyak, K; Prasad, A | 1 |
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| Bongarzone, I; Cassinelli, G; Cremona, M; Cuccuru, G; Gorla, L; Lanzi, C; Miccichè, F; Mondellini, P; Pierotti, MA | 1 |
| Baardsnes, J; Le, PU; Lenferink, AE; Massie, B; O'Connor-McCourt, MD; Pinard, M | 1 |
| Balducci, J; Gan, Y; Huang, Y; Ma, F; Sun, H; Wei, YQ; Wu, W; Yang, H; Zhang, D; Zhao, X | 1 |
| Ali, S; Alvarez, L; Campiglio, M; Cocolakis, E; Di Fulvio, M; Feng, Z; Gomez-Cambronero, J; Haines, E; Lebrun, JJ; Minoo, P; Nie, XM; Resalatpanah, N; Ridha, M | 1 |
| Adams, TE; Bentley, JD; Burgess, AW; Hoyne, PH; Johns, TG; Koziolek, EJ; Lee, FT; Lovrecz, G; Lu, L; Nash, AD; Nice, EC; Rothacker, J; Scott, AM; Ward, CW | 1 |
| Buday, L; Cance, WG; Choi, MC; Choi, S; Kim, SH; Ko, W; Lee, JW; Lee, MJ; Lee, SA; Oh, ES; Oh, MA | 1 |
| Bessette, DC; Chen, SC; Khanna, RS; Pallen, CJ; Samayawardhena, LA | 1 |
| Camp, DG; Ding, SJ; Heibeck, TH; Monroe, ME; Opresko, LK; Qian, WJ; Schepmoes, AA; Smith, RD; Tolmachev, AV; Wiley, HS; Yang, F; Zhao, R | 1 |
| Honma, S; Kikuchi, H; Nakahata, N; Oshima, Y; Saito, M; Saito, Y; Yoshida, M | 1 |
| Arias, M; Bravo-Cordero, JJ; Chen, X; Condeelis, J; Desmarais, V; Koleske, AJ; Mader, CC; Oser, M; van Rheenen, J; Yamaguchi, H | 1 |
| Boekhorst, J; Boersema, PJ; Choo, AB; den Hertog, J; Ding, VM; Foong, LY; Heck, AJ; Lemeer, S; Philp, R; Snel, B; van Breukelen, B | 1 |
| Hong, W; Liu, NS; Loh, E; Loo, LS; Seet, LF | 1 |
| Lim, SK; Lim, YP; Loh, MC; Toy, W | 1 |
| Shao, H; Wells, A; Wu, C | 1 |
| Bastiaens, PI; Frahm, T; Girod, A; Grecco, HE; Hou, J; Pepperkok, R; Roda-Navarro, P; Squire, A; Truxius, DC | 1 |
| Cheang, TY; Li, W; Lin, Y; Liu, Y; Wang, M; Wang, S; Ye, C; Zhang, H; Zhang, L | 1 |
| Asara, JM; Peng, M; Tyner, AL; Wang, Z; Zheng, Y | 1 |
| Berthois, Y; Calvo, F; Huet, E; Ma, L; Menashi, S; Mourah, S; Serova, M | 1 |
| Konishi, H; Maki, M; Ohta, T; Shibata, H; Tsunematsu, T; Yamauchi, E | 1 |
| Ammer, AG; Hayes, KE; Kelley, LC; Martin, KH; Weed, SA | 1 |
| Gotoh, N; Hattori, S; Inoue, J; Kozuka-Hata, H; Miyano, S; Nagasaki, M; Oyama, M; Semba, K; Sugano, S; Tasaki, S; Yamamoto, T | 1 |
| Bald, L; Fayadat-Dilman, L; Grein, J; Janatpour, MJ; Vanderlaag, K; Wagner, J; Wang, W | 1 |
| Hussaini, IM; Lopes, MB; Merk, BC; Owens, JL; Silva, CM | 1 |
| Bernard, JK; Dise, RS; Frey, MR; Polk, DB; Yamaoka, T | 1 |
| Anglin, IE; Goldblum, SE; Hyun, SW; Lillehoj, E; Liu, A; Passaniti, A; Sorkin, JD; Tonks, NK; Yang, S | 1 |
| Caldwell-Busby, J; Gnanasambandan, K; Kamarajugadda, S; Sayeski, PP; Sayyah, J; Tsuda, S | 1 |
| Bursulaya, B; Deaton, LM; Gauba, V; Geierstanger, BH; Gorney, V; Grünewald, J; Kang, M; Lerner, RA; Ou, W; Ramirez-Montagut, T; Schmedt, C; Schultz, PG | 1 |
| Chen, Y; Choong, LY; Lim, SK; Lim, YP; Loh, MC; Salto-Tellez, M; Shah, N; Toy, W; Wong, CY | 1 |
| Balanis, N; Carlin, CR; Schiemann, WP; Wendt, MK; Yoshigi, M | 1 |
| Chen, Y; Lan, T; Qu, R; Sang, J; Wu, Y | 1 |
| Adams, G; Aikhionbare, F; Cao, X; Chen, Y; Ding, X; Fan, L; Frost, A; Hu, G; Liu, D; Liu, H; Partridge, E; Wang, F; Yao, X; Yu, X | 1 |
| Ades, LM; Buchman, J; Gallo, RM; Hernandez-Gordillo, V; Lambert, S; Mill, C; Riese, DJ; Settleman, J; Wilson, KJ; Wilson, TR | 1 |
| Anderson, DH; Ge, B; Li, Z; Meng, S; Pan, W; Wang, C; Zhang, M; Zhang, S | 1 |
| Hanafusa, H; Ishikawa, K; Matsumoto, K; Nara, A | 1 |
| Gui, A; Kitazawa, M; Kobayashi, A; Miyagawa, S; Motoyama, H; Takeoka, M | 1 |
| Hiyoshi, M; Ishii, A; Kamimori, K; Kido, H; Konishi, H; Ohta, T | 1 |
| Assiddiq, BF; Chan, SP; Chong, PK; Lim, YP; Tan, KY; Toy, W | 1 |
| Angeloni, A; Mancini, P; Mezi, S; Orsi, E; Todi, L | 1 |
| Grudinkin, PS; Kozyulina, PY; Nikolsky, NN; Okorokova, LS | 1 |
| Delle Fave, G; Di Florio, A; Jensen, RT; Moreno, P; Sancho, V | 1 |
| Kerperien, J; Meijer, IM; Sotoca, AM; van Leeuwen, JE; van Zoelen, EJ | 1 |
| Wang, J; Yu, L; Zheng, X | 1 |
| Carraway, KL; Hong, SY; Li, T; Lo, SH; Shih, YP | 1 |
| Lyons, BA; Madanayake, T; Paudyal, P; Rohrschneider, LR; Rowland, A; Shrestha, S; Shuster, CB | 1 |
| Dudem, S; Jain, N; Kalivendi, SV; Vangala, JR | 1 |
| Aguiar, M; Arellano, M; Boggon, TJ; Chen, J; Chung, TW; Elf, S; Fan, J; Gu, TL; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lin, R; Lonning, S; Shan, C; Shin, DM; Xie, J | 1 |
| Alberts, P; Mari, S; Maspero, E; Moran, MF; Murchie, R; Persaud, A; Polo, S; Rotin, D; Safi, F; Tong, J | 1 |
| Alex Gaither, L; Bentires-Alj, M; Bonenfant, D; Leroy, C; Lezan, E; McLaughlin, ME; Meyer, R; Shen, Q; Strande, V; Voshol, H | 1 |
| Goff, SP; Wang, GZ | 1 |
| Batta, G; Csomós, I; Hajdu, T; Kovács, T; Nagy, P; Szabó, Á; Szöllősi, J; Váradi, T; Zákány, F | 1 |
| Dong, M; Li, Y; Wang, Y; Ye, M; Zou, H | 1 |
| Chen, L; Chen, Y; Hong, W; Lin, X; Wang, T; Xu, X; Zhang, J | 1 |
| Chen, B; Chen, S; Hou, Z; Jiang, Z; Li, Y; Lin, Z; Wang, Y; Zhou, T | 1 |
| Gill, K; Macdonald-Obermann, JL; Pike, LJ | 1 |
| Boveris, A; Buchholz, B; Gelpi, RJ; Helfenberger, KE; Poderoso, C; Poderoso, JJ; Villalba, NM | 1 |
| Chakrabandhu, K; Huault, S; Hueber, AO; Ta, NL | 1 |
| Gou, Q; Hou, Y; Jiang, Y; Shi, J; Xu, H; Xu, Y; Zhang, R; Zhang, W | 1 |
| Hofkens, J; Kluba, M; Mizuno, H; Thirukkumaran, OM | 1 |
| Kamptner, AZM; Stütz, A; Sutterlüty, H | 1 |
| Fukui, K; Horimoto, K; Kagiwada, H; Kiboku, T; Kitazawa, M; Matsuo, H | 1 |
| Yuki, R | 1 |
| Feng, Y; Jin, X; Liu, J; Peng, P; Qu, Y; Shu, H; Wang, L; Wang, Y; Wei, M; Xia, M | 1 |
| Gong, JL; Gu, B; Lan, T; Li, SB; Li, Y; Luo, L; Ma, P; Mu, CY; Tao, AB; Wang, Y; Wang, ZC; Xu, H; Zhou, Y | 1 |
| Lin, Q; Peng, Z; Sun, A; Tian, X; Wu, T; Yang, W; Zhu, J | 1 |
| Bonavia, R; Faraguna, JS; Furnari, FB; Gerritsen, JS; White, FM | 1 |
7 review(s) available for tyrosine and epidermal growth factor
| Article | Year |
|---|---|
[Properties of protein-tyrosine kinases (minireview)].
Topics: Animals; Catalysis; Enzyme Activation; Epidermal Growth Factor; Humans; Oncogene Proteins, Viral; Oncogenic Viruses; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine | 1989 |
Protein-tyrosine kinases.
Topics: Amino Acid Sequence; Animals; Binding Sites; Epidermal Growth Factor; ErbB Receptors; Humans; Lipid Metabolism; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Cell Surface; Retroviridae; Serine; Substrate Specificity; Threonine; Tyrosine; Viral Proteins | 1985 |
Epidermal growth factor and its receptor.
Topics: Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Humans; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogenes; Threonine; Tyrosine | 1987 |
The insulin receptor and tyrosine protein kinase activity.
Topics: Adenosine Triphosphate; Animals; Avian Sarcoma Viruses; Cations, Divalent; Cell Membrane; Cell Transformation, Viral; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Insulin; Macromolecular Substances; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Serine; Substrate Specificity; Tyrosine | 1984 |
Zonula occludens (ZO)-1 and ZO-2: membrane-associated guanylate kinase homologues (MAGuKs) of the tight junction.
Topics: Amino Acid Sequence; Animals; Conserved Sequence; Epidermal Growth Factor; Guanylate Kinases; Humans; Membrane Proteins; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Phosphoproteins; Phosphorylation; Signal Transduction; Tight Junctions; Tyrosine; Zonula Occludens-1 Protein; Zonula Occludens-2 Protein | 1995 |
EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling.
Topics: Animals; Autocrine Communication; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Mice; Paracrine Communication; Phosphorylation; Proto-Oncogene Proteins c-cbl; Tyrosine | 2012 |
[Aberrant Activation Mechanism of TGF-β Signaling in Epithelial-mesenchymal Transition].
Topics: Animals; Cell Movement; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; ErbB Receptors; Humans; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-abl; Signal Transduction; Smad Proteins; Transcription Factors; Transforming Growth Factor beta; Tyrosine | 2021 |
661 other study(ies) available for tyrosine and epidermal growth factor
| Article | Year |
|---|---|
Growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial cells.
Topics: Adenosine Triphosphate; Autoradiography; Cells, Cultured; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Eye Proteins; Fetus; Fibroblast Growth Factor 2; Humans; Membrane Proteins; Phosphorylation; Phosphotyrosine; Pigment Epithelium of Eye; Platelet-Derived Growth Factor; Signal Transduction; Tyrosine | 1992 |
Effects of EGF-dextran-tyrosine-131I conjugates on the clonogenic survival of cultured glioma cells.
Topics: Brain Neoplasms; Cell Survival; Culture Media; Dextrans; Drug Carriers; Epidermal Growth Factor; Glioma; Humans; Iodine Radioisotopes; Time Factors; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine | 1992 |
Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate.
Topics: Animals; Cell Line; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Fluorescent Antibody Technique; Genes, src; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Transfection; Tyrosine | 1992 |
Inhibition of EGF-induced gastric mucosal calcium channel phosphorylation by ebrotidine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Ulcer Agents; Benzenesulfonates; Calcium Channels; Calcium Radioisotopes; Epidermal Growth Factor; Gastric Mucosa; Isradipine; Phosphorylation; Phosphotyrosine; Rats; Thiazoles; Tyrosine | 1992 |
Modulation of gastric mucosal calcium channel activity by sucralfate.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Epidermal Growth Factor; Gastric Mucosa; In Vitro Techniques; Isradipine; Phosphorylation; Rats; Sucralfate; Tyrosine | 1992 |
Importance of tyrosine phosphatases in the effects of cell-cell contact and microenvironments on EGF-stimulated tyrosine phosphorylation.
Topics: Blotting, Western; Cell Communication; Cell Division; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1992 |
Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Molecular Sequence Data; Mutation; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Rabbits; Rats; Serine; Signal Transduction; Threonine; Tyrosine | 1992 |
Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase.
Topics: 3T3 Cells; Amino Acid Sequence; Amino Acids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Epidermal Growth Factor; Humans; Kinetics; Mice; Mutagenesis, Site-Directed; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Threonine; Tyrosine | 1992 |
Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Endocytosis; Epidermal Growth Factor; Hemolysis; Humans; Kinetics; Liver Neoplasms, Experimental; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Conformation; Rats; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Substrate Specificity; Tissue Plasminogen Activator; Transfection; Tyrosine | 1992 |
Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.
Topics: 3T3 Cells; Animals; Catalysis; Cell Membrane; Chromatography, Gel; Cytosol; Detergents; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Humans; Inositol 1,4,5-Trisphosphate; Insulin; Isoenzymes; Kinetics; Mice; Octoxynol; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphorylation; Platelet-Derived Growth Factor; Polyethylene Glycols; Precipitin Tests; Type C Phospholipases; Tyrosine | 1992 |
A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor.
Topics: 3T3 Cells; Animals; Base Sequence; Codon; DNA Replication; Drug Resistance; Epidermal Growth Factor; ErbB Receptors; Gentamicins; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenylalanine; Protein-Tyrosine Kinases; Transfection; Tyrosine | 1992 |
Atypical receptor-mediated signal transduction events in the EGF-dependent growth-inhibited cell line, MDA-468.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Humans; Phosphatidylinositols; Phosphorylation; Precipitin Tests; Proteins; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1992 |
Activation of dihydropyridine-sensitive parotid salivary gland calcium channels by epidermal growth factor.
Topics: Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Isradipine; Lanthanum; Liposomes; Male; Parotid Gland; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine | 1992 |
Protein phosphotyrosine in mouse brain: developmental changes and regulation by epidermal growth factor, type I insulin-like growth factor, and insulin.
Topics: Animals; Astrocytes; Brain; Cell Aggregation; Cerebral Cortex; Embryo, Mammalian; Epidermal Growth Factor; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred Strains; Neurons; Phosphorylation; Phosphotyrosine; Tyrosine | 1992 |
Cell biology. Devious devices of Salmonella.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Humans; Microscopy, Electron; Microvilli; Phosphotyrosine; Salmonella typhimurium; Signal Transduction; Tyrosine | 1992 |
Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes.
Topics: 3T3 Cells; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Growth Hormone; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Staurosporine; Tyrosine | 1992 |
Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; Substrate Specificity; Thymidine; Transfection; Tyrosine | 1992 |
Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chromatography, Affinity; Cross-Linking Reagents; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Mice; Molecular Sequence Data; Phosphotyrosine; Protein Conformation; Tyrosine | 1992 |
Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.
Topics: Amino Acid Sequence; Base Sequence; Cytoskeletal Proteins; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Sequence Alignment; Tumor Cells, Cultured; Tyrosine | 1992 |
Epidermal growth factor stimulates tyrosine phosphorylation in the neonatal mouse: association of a M(r) 55,000 substrate with the receptor.
Topics: Animals; Animals, Newborn; Epidermal Growth Factor; ErbB Receptors; Macromolecular Substances; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Binding; Signal Transduction; Tissue Distribution; Tyrosine | 1992 |
Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Liver; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Tyrosine | 1992 |
Alterations in the subcellular distribution of p21ras-GTPase activating protein in proliferating rat acinar cells.
Topics: Animals; Cell Division; Cell Fractionation; Cell Membrane; Centrifugation, Density Gradient; Epidermal Growth Factor; Female; Golgi Apparatus; GTPase-Activating Proteins; Immunosorbent Techniques; Intracellular Membranes; Isoproterenol; Kinetics; Nuclear Envelope; Parotid Gland; Phosphorylation; Phosphotyrosine; Proteins; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Epidermal Growth Factor; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Immunoblotting; Isoenzymes; Kinetics; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine | 1992 |
Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains.
Topics: 3T3 Cells; Animals; Enzyme Activation; Epidermal Growth Factor; Genes, src; Immunoblotting; Insulin; Kinetics; Macromolecular Substances; Mice; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, trkA; Tyrosine | 1992 |
Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
Topics: Animals; Cell Division; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Kinetics; Liver; Mitogens; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Rats; Thymidine; Tyrosine | 1992 |
Epidermal growth factor receptor in synaptic fractions of the rat central nervous system.
Topics: Animals; Brain Chemistry; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Immunohistochemistry; Liver; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Substrate Specificity; Synaptosomes; Tyrosine | 1992 |
Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.
Topics: Animals; Autoradiography; Blotting, Western; Calcium; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Humans; Inositol 1,4,5-Trisphosphate; Liver; Male; Phosphorylation; Precipitin Tests; Rats; Rats, Wistar; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1992 |
The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cattle; Cell Division; Cell Line; Epidermal Growth Factor; Humans; Mice; Molecular Sequence Data; Oncogene Proteins; Peptide Mapping; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Rats; Sequence Homology, Amino Acid; Serine; Sulfhydryl Compounds; Type C Phospholipases; Tyrosine | 1992 |
Transforming growth factor beta modulates phosphorylation of the epidermal growth factor receptor and proliferation of A431 cells.
Topics: Cell Division; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Half-Life; Humans; Phosphorylation; Resting Phase, Cell Cycle; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured; Tyrosine | 1992 |
Enhancement of epidermal growth factor (EGF) and insulin-stimulated tyrosine phosphorylation of endogenous substrates by sodium selenate.
Topics: 3T3 Cells; Animals; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Insulin; Mice; Phosphorylation; Selenic Acid; Selenium; Selenium Compounds; Substrate Specificity; Tyrosine | 1992 |
Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach.
Topics: Amino Acid Sequence; Base Sequence; Calcium; Cell Line; Chimera; DNA; Epidermal Growth Factor; Humans; Hydrogen-Ion Concentration; Ligands; Molecular Sequence Data; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Thymidine; Transfection; Tyrosine | 1991 |
Temperature-dependent tyrosine phosphorylation of microtubule-associated protein kinase in epidermal growth factor-stimulated human fibroblasts.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Phorbol Esters; Phosphorylation; Protein Kinases; Temperature; Tyrosine | 1991 |
Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Autoradiography; Breast Neoplasms; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Humans; Kinetics; Lung Neoplasms; Membrane Proteins; Molecular Sequence Data; Pancreatic Neoplasms; Phosphorus Radioisotopes; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Somatostatin; Triptorelin Pamoate; Tyrosine | 1991 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Topics: Alkaloids; Animals; Calcimycin; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phorbol 12,13-Dibutyrate; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tumor Cells, Cultured; Tyrosine | 1990 |
Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Line; Epidermal Growth Factor; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Weight; Phosphorylation; Phosphotyrosine; Sequence Homology, Nucleic Acid; Type C Phospholipases; Tyrosine | 1990 |
Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Topics: Annexins; Calcium; Calcium-Binding Proteins; Carcinoma, Squamous Cell; Cell Division; Cytoplasm; Drug Tolerance; Epidermal Growth Factor; ErbB Receptors; Humans; Mutation; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1990 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins.
Topics: Animals; Bombesin; Cell Line; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Insulin and epidermal growth factor stimulate phosphorylation of p185HER-2 in the breast carcinoma cell line, BT474.
Topics: Blood; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1990 |
Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Immunoblotting; Insulin; Insulin-Like Growth Factor I; Liver; Phosphorylation; Phosphotyrosine; Portal Vein; Proteins; Rats; Receptor, Insulin; Tyrosine | 1990 |
Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Epidermal growth factor induces tyrosine phosphorylation of epidermal growth factor receptors not occupied with ligand in intact A431 cells.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Ligands; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1990 |
Examination of the role of serine phosphorylation in phospholipase C-gamma and its related P47 in cAMP-mediated depression of epidermal growth factor signal transduction.
Topics: Colforsin; Cross Reactions; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1990 |
Functional state of the epidermal growth factor-receptor complexes during their internalization in A-431 cells.
Topics: Biological Transport; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphotyrosine; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 1990 |
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Mice; Phosphotyrosine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thionucleotides; Tyrosine | 1990 |
Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis.
Topics: Animals; Cell Line; Enzyme Activation; Epidermal Growth Factor; Epithelium; Hydrolysis; Immunoblotting; Immunosorbent Techniques; Isoenzymes; Liver; Mice; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tyrosine | 1990 |
[The immunofluorescent detection of phosphorylated receptors of the epidermal growth factor during their internalization in A-431 cells].
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Phosphorylation; Phosphotyrosine; Staining and Labeling; Temperature; Tumor Cells, Cultured; Tyrosine | 1990 |
Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation.
Topics: Catalysis; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Immunosorbent Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1990 |
Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Calcimycin; Calcium; Cell Line; Epidermal Growth Factor; Ionomycin; Kinetics; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Terpenes; Thapsigargin; Tyrosine | 1990 |
Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src.
Topics: Animals; Cell Line; DNA Replication; Epidermal Growth Factor; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Mice; Mutation; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Tyrosine | 1990 |
Anti-phosphotyrosine immunoprecipitation of phosphatidylinositol 3' kinase activity in different cell types after exposure to epidermal growth factor.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Humans; Immune Sera; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Tyrosine | 1990 |
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Topics: Amino Acids; Cell Division; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.
Topics: Animals; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Oncogene Protein pp60(v-src); Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 1991 |
MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways.
Topics: Adipose Tissue; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Reactivators; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Oocytes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Tyrosine; Xenopus | 1991 |
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Topics: Animals; Blotting, Southern; Burkitt Lymphoma; Cell Division; DNA, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genetic Vectors; Humans; In Vitro Techniques; Mice; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Phosphotyrosine; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1991 |
Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; In Vitro Techniques; Isoenzymes; Nerve Growth Factors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Type C Phospholipases; Tyrosine | 1991 |
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Genes, src; GTPase-Activating Proteins; Mutagenesis, Site-Directed; Peptide Mapping; Phosphopeptides; Phosphorylation; Proteins; Proto-Oncogene Proteins pp60(c-src); ras GTPase-Activating Proteins; Rats; Transfection; Tyrosine | 1991 |
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.
Topics: Animals; Cell Line; DNA; DNA Mutational Analysis; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Genes, Dominant; Genes, Suppressor; Ligands; Macromolecular Substances; Mice; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor Aggregation; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1991 |
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
Topics: Amino Acid Sequence; Binding Sites; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Sorting Signals; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Sequence Homology, Nucleic Acid; Signal Transduction; Type C Phospholipases; Tyrosine | 1991 |
The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.
Topics: Animals; Catechols; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Humans; In Vitro Techniques; Keratinocytes; Molecular Weight; Nitriles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine; Tyrphostins | 1991 |
Heparin stimulates epidermal growth factor receptor-mediated phosphorylation of tyrosine and threonine residues.
Topics: Amino Acids; Animals; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Glutathione Transferase; Heparin; Humans; Insecta; Manganese; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Threonine; Tyrosine | 1991 |
Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Membrane; Colforsin; Corpus Luteum; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; In Vitro Techniques; Molecular Weight; Phosphorylation; Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Chromosome Deletion; Epidermal Growth Factor; ErbB Receptors; Kinetics; Membrane Potentials; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 1991 |
Insulin-like growth factor I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon carcinoma 26 NL-17 cells.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Colonic Neoplasms; Epidermal Growth Factor; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Molecular Weight; Neoplasm Metastasis; Neoplasm Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Somatomedin; Sepharose; Tyrosine | 1991 |
Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Line; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Female; Haptens; Humans; Indicators and Reagents; Mice; Mice, Inbred BALB C; Molecular Weight; Phosphoproteins; Phosphotyrosine; Radioimmunoassay; Tyrosine | 1991 |
Purification of mitogen-activated protein kinase from epidermal growth factor-treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Autoradiography; Buffers; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Indicators and Reagents; Kinetics; Mice; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Tyrosine | 1991 |
Epidermal growth factor-specific protein tyrosine phosphorylation in preimplantation embryo development.
Topics: Animals; Blastocyst; Catechols; Embryonic Development; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Nitriles; Phosphorylation; Phosphotyrosine; Pregnancy; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Tyrphostins | 1991 |
Immunodetection of the ligand-activated receptor for epidermal growth factor.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cell Line; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fluorescent Antibody Technique; Humans; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Tyrosine | 1991 |
Growth factor signal transduction in human intestinal cells.
Topics: Carcinoma; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Kinetics; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1991 |
[The direct demonstration of the tyrosine phosphorylation of epidermal growth factor receptors internalized in the endosomes of A431 cells].
Topics: Antibodies; Carcinoma, Squamous Cell; Cell Fractionation; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Organelles; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1991 |
Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells.
Topics: Animals; Carcinoma; Culture Media; Epidermal Growth Factor; ErbB Receptors; Female; Growth Substances; Mammary Neoplasms, Experimental; Neoplasm Proteins; Phenotype; Phosphoproteins; Phosphotyrosine; Rats; Tyrosine | 1991 |
Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis.
Topics: Animals; Base Sequence; Catechols; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Immunoenzyme Techniques; Lung; Mice; Molecular Sequence Data; Morphogenesis; Nitriles; Organ Culture Techniques; Phosphorylation; Signal Transduction; Transcription, Genetic; Tyrosine; Tyrphostins | 1992 |
Epidermal growth factor (EGF)-stimulated tyrosine phosphorylation and EGF receptor degradation in cells expressing EGF receptors truncated at residue 973.
Topics: 3T3 Cells; Animals; Blotting, Western; Epidermal Growth Factor; ErbB Receptors; Mice; Phosphorylation; Precipitin Tests; Substrate Specificity; Type C Phospholipases; Tyrosine | 1992 |
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation.
Topics: Animals; Carbazoles; Epidermal Growth Factor; Genistein; Guanosine Diphosphate; Guanosine Triphosphate; Indole Alkaloids; Isoflavones; Kinetics; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Tyrosine | 1991 |
p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.
Topics: Animals; Cell Line; Cricetinae; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Mitogen-Activated Protein Kinase 1; Pertussis Toxin; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1991 |
Epidermal growth factor and 12-tetradecanoyl phorbol 13-acetate induction of urokinase in A431 cells.
Topics: Chromogenic Compounds; Electrophoresis, Gel, Two-Dimensional; Enzyme Induction; Epidermal Growth Factor; Humans; Oligopeptides; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 1991 |
EGF rapidly stimulates tyrosine phosphorylation in cultured endometrial cells.
Topics: Cells, Cultured; Endometrium; Epidermal Growth Factor; Estradiol; Female; Humans; Phosphorylation; Tyrosine | 1991 |
Autophosphorylation of the intracellular domain of the epidermal growth factor receptor results in different effects on its tyrosine kinase activity with various peptide substrates. Phosphorylation of peptides representing Tyr(P) sites of phospholipase C-
Topics: Amino Acid Sequence; Angiotensin II; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Kinetics; Molecular Sequence Data; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Substrate Specificity; Type C Phospholipases; Tyrosine | 1991 |
Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.
Topics: Animals; Contractile Proteins; Epidermal Growth Factor; ErbB Receptors; Inositol Phosphates; Isoenzymes; Kinetics; Microfilament Proteins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Profilins; Protein-Tyrosine Kinases; Signal Transduction; Type C Phospholipases; Tyrosine | 1991 |
Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Insulin; Kinetics; Microtubule-Associated Proteins; Nerve Growth Factors; Pheochromocytoma; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rats; Tyrosine | 1991 |
PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate.
Topics: Amino Acid Sequence; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Mice; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Platelet-Derived Growth Factor; Tyrosine | 1991 |
[Roles of protein kinase C substrates in signal transduction].
Topics: Animals; Cell Division; Cloning, Molecular; Epidermal Growth Factor; ErbB Receptors; Phosphorylation; Protein Kinase C; Signal Transduction; Tyrosine | 1991 |
Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action.
Topics: Autoradiography; Blotting, Western; Carcinoma, Squamous Cell; Ceramides; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Humans; Peptide Mapping; Phosphorylation; Signal Transduction; Sphingosine; Tumor Cells, Cultured; Tyrosine | 1991 |
Structure-function relationships in human epidermal growth factor studied by site-directed mutagenesis and 1H NMR.
Topics: Animals; Arginine; Epidermal Growth Factor; ErbB Receptors; Genetic Variation; Haplorhini; Humans; Magnetic Resonance Spectroscopy; Mice; Mutagenesis, Site-Directed; Protein Conformation; Radioligand Assay; Structure-Activity Relationship; Tyrosine; Vero Cells | 1991 |
Differential binding and biological activities of epidermal growth factor and transforming growth factor alpha in a human pancreatic cancer cell line.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Iodine Radioisotopes; Pancreatic Neoplasms; Phosphorylation; Statistics as Topic; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1991 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Reduced tyrosine phosphorylation and nonresponsiveness to EGF-mediated cytotoxicity in EGF receptor-hyperproducing UCVA-1 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Peptide Mapping; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Human epidermal growth factor. Distinct roles of tyrosine 37 and arginine 41 in receptor binding as determined by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.
Topics: Amino Acid Sequence; Arginine; Binding, Competitive; Epidermal Growth Factor; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Protein Conformation; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 1990 |
Insulin, epidermal growth factor and fibroblast growth factor elicit distinct patterns of protein tyrosine phosphorylation in BC3H1 cells.
Topics: Animals; Cell Line; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factors; Insulin; Mice; Muscles; Phorbol Esters; Phosphorylation; Protein-Tyrosine Kinases; Substrate Specificity; Tyrosine | 1990 |
Epidermal growth factor (EGF)-nonresponsive variants of normal rat kidney cell line: response to EGF and transforming growth factor-beta.
Topics: Animals; Cell Line; Cell Separation; DNA; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gene Expression; Genetic Variation; Glucose; Kidney; Phosphorylation; Rats; Transforming Growth Factors; Tyrosine | 1990 |
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cells.
Topics: Animals; Autoradiography; Calcium; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mice; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proteins; Time Factors; Tyrosine | 1985 |
Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; Chromosomes, Human, 6-12 and X; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Gene Amplification; Humans; Neoplasm Proteins; Phosphoproteins; Phosphotyrosine; Receptors, Cell Surface; RNA, Messenger; RNA, Neoplasm; Translocation, Genetic; Tyrosine | 1985 |
Association of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Line; Cytoskeleton; Epidermal Growth Factor; ErbB Receptors; Humans; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cell Surface; Tyrosine | 1985 |
Inhibition of epidermal growth factor-induced phosphorylation by trifluoperazine.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line; Chlorpromazine; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Imipramine; Mice; Microscopy, Electron, Scanning; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Sulfonamides; Trifluoperazine; Tyrosine | 1985 |
Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone.
Topics: Brain; Calmodulin-Binding Proteins; Cations, Monovalent; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Phosphorylation; Phosphoserine; Phosphotyrosine; Placenta; Pregnancy; Receptors, Cell Surface; Tyrosine | 1985 |
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: Amino Acids; Animals; Carcinoma, Squamous Cell; Cattle; Cell Division; Cell Line; Depression, Chemical; Dogs; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblasts; G(M1) Ganglioside; G(M3) Ganglioside; Gangliosides; Humans; Immunosorbent Techniques; Mice; Mouth Neoplasms; Ovarian Neoplasms; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1986 |
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.
Topics: Antibodies, Monoclonal; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1986 |
Stimulation of the phosphorylation of a 66,000-Da soluble tyrosine phosphoprotein by agents that activate or augment activation of human peripheral blood T lymphocytes.
Topics: Calcimycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Wheat Germ Agglutinins | 1987 |
A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the c-erbB-2 gene.
Topics: Epidermal Growth Factor; Glycoproteins; Humans; KB Cells; Molecular Weight; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Proto-Oncogenes; Tyrosine | 1987 |
Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Immunosorbent Techniques; Insulin; Insulin-Like Growth Factor I; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Receptor, Insulin; Receptors, Somatomedin; Somatomedins; Tyrosine | 1987 |
Epidermal growth factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver.
Topics: Animals; Endopeptidases; Epidermal Growth Factor; Liver; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Serine; Serine Endopeptidases; Tyrosine | 1987 |
The quantity of protein-bound [32P]phosphotyrosine in hepatocytes and fibroblasts. The effects of tyrosine protein kinase activating agents.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Liver; Phosphoproteins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tyrosine | 1987 |
Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells.
Topics: Amino Acids; Antibodies; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Kinetics; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Trypsin; Tyrosine | 1987 |
Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies.
Topics: Antibodies, Monoclonal; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Ligands; Macromolecular Substances; Microinjections; Mutation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tyrosine | 1988 |
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.
Topics: Antibodies; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Cytosol; Epidermal Growth Factor; Hydrolysis; Inositol Phosphates; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Substrate Specificity; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1988 |
Nerve growth factor induces protein-tyrosine phosphorylation.
Topics: Adrenal Gland Neoplasms; Animals; Bucladesine; Cell Line; Epidermal Growth Factor; Immunosorbent Techniques; Nerve Growth Factors; Pheochromocytoma; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Tyrosine | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Dexamethasone-induced changes in phosphorylation of the insulin and epidermal growth factor receptors and their substrates in intact rat hepatocytes.
Topics: Animals; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Fasting; Insulin; Liver; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1988 |
Characterization of a high-molecular-weight protein immunoprecipitated by platelet-derived growth factor antisera.
Topics: Cell Line; Cross Reactions; Epidermal Growth Factor; Humans; Immune Sera; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tyrosine | 1988 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Bradykinin; Calcium; Cell Line; Epidermal Growth Factor; ErbB Receptors; Immunoassay; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Type C Phospholipases; Tyrosine | 1989 |
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.
Topics: Antineoplastic Agents; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Tyrphostins | 1989 |
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Calcium; Casein Kinases; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphotyrosine; Protein Kinase C; Protein Kinases; Temperature; Tumor Cells, Cultured; Tyrosine | 1989 |
The A-type receptor for platelet-derived growth factor mediates protein tyrosine phosphorylation, receptor transmodulation and a mitogenic response.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; Humans; In Vitro Techniques; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Time Factors; Tyrosine | 1989 |
EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor.
Topics: Animals; Calcimycin; Cell Differentiation; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Interleukin-3; Mast Cells; Mice; Oncogene Proteins; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Regulation by intracellular Ca2+ and cyclic AMP of the growth factor-induced ruffling membrane formation and stimulation of fluid-phase endocytosis and exocytosis.
Topics: Bucladesine; Calcimycin; Calcium; Cell Membrane; Colforsin; Cyclic AMP; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1989 |
Epidermal growth factor stimulates tyrosine phosphorylation of pig epidermal fibrous keratin.
Topics: Animals; Autoradiography; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Epidermis; Immunologic Techniques; Keratins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Swine; Tyrosine | 1985 |
Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.
Topics: Animals; Cell Line; Chimera; Chromatography; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Tyrosine | 1989 |
Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Deoxy Sugars; Deoxyglucose; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Protein-Tyrosine Kinases; Structure-Activity Relationship; Transfection; Tyrosine | 1989 |
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.
Topics: Animals; Catechols; Cell Division; Cell Line; DNA; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Growth Inhibitors; Kinetics; Mice; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine; Tyrphostins | 1989 |
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.
Topics: Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1988 |
Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies.
Topics: Annexins; Antibodies, Monoclonal; Cell Transformation, Viral; Epidermal Growth Factor; Humans; Membrane Proteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Retroviridae Proteins; Serine; Tyrosine | 1986 |
Protein phosphorylation and growth control.
Topics: Animals; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Insulin-Like Growth Factor I; Mitogens; Oncogene Proteins, Viral; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Receptors, Somatomedin; Retroviridae; Tyrosine | 1985 |
Effects of protein kinase C activation after epidermal growth factor binding on epidermal growth factor receptor phosphorylation.
Topics: Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Kinase C; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1986 |
Epidermal growth factor stimulates tyrosine phosphorylation of human glucocorticoid receptor in cultured cells.
Topics: Breast; Cell Line; Dexamethasone; Epidermal Growth Factor; Female; Humans; Phosphorylation; Receptors, Glucocorticoid; Serine; Tyrosine | 1987 |
Mitogen-stimulated tyrosine phosphorylation of a 42-kD cellular protein: evidence for a protein kinase-C requirement.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mitogens; Molecular Weight; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1988 |
EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.
Topics: Amino Acids; Animals; Antibodies, Monoclonal; Cell Line; Epidermal Growth Factor; ErbB Receptors; Genes; Models, Biological; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogenes; Tyrosine | 1988 |
Epidermal growth factor, but not insulin, stimulates tyrosine phosphorylation of an endogenous protein of Mr 95,000 in triton extracts of human placental syncytiotrophoblast membranes.
Topics: Amino Acids; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Heparin; Humans; Insulin; Phosphorylation; Proteins; Spermine; Stimulation, Chemical; Trophoblasts; Tyrosine | 1987 |
Photo-CIDNP nuclear magnetic resonance as a probe for conformational changes in epidermal growth factor.
Topics: Animals; Epidermal Growth Factor; Histidine; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mice; Protein Conformation; Salivary Glands; Tryptophan; Tyrosine | 1986 |
Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.
Topics: Animals; Cell Line; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Interphase; Kinetics; Mice; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Comparison of tyrosine phosphorylation of proteins by membrane fractions from mouse liver, Ehrlich ascites tumor and MH134 hepatoma.
Topics: Animals; Carcinoma, Ehrlich Tumor; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; In Vitro Techniques; Liver; Liver Neoplasms, Experimental; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine | 1985 |
Characterization of structural domains of the human epidermal growth factor receptor obtained by partial proteolysis.
Topics: Carbohydrates; Carcinoma; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Weight; Peptide Fragments; Phosphorylation; Receptors, Cell Surface; Trypsin; Tyrosine | 1984 |
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Chromatography, Thin Layer; Electrophoresis, Paper; Enzyme Activation; Epidermal Growth Factor; Humans; Membrane Proteins; Peptides; Phosphotyrosine; Protein Kinases; Tyrosine | 1980 |
Differences in mechanisms of transformation by independent feline sarcoma virus isolates.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Mink; Phosphotyrosine; Protein Kinases; Rats; Retroviridae; Sarcoma Viruses, Feline; Tyrosine; Viral Proteins | 1981 |
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Tyrosine | 1981 |
Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus.
Topics: Avian Sarcoma Viruses; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Receptors, Cell Surface; Tyrosine | 1981 |
Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration.
Topics: Animals; Cell Division; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Regeneration; Male; Microsomes, Liver; Phosphoproteins; Phosphotyrosine; Protein Kinases; Rats; Receptors, Cell Surface; Tyrosine | 1982 |
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1982 |
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins.
Topics: Amino Acids; Animals; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Kinetics; Mice; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Proteins; Tyrosine | 1982 |
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.
Topics: Animals; Cell Membrane; Epidermal Growth Factor; Growth Substances; Manganese; Membrane Proteins; Mice; Molecular Weight; Peptides; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Tyrosine | 1983 |
Avian sarcoma viruses, protein kinases and cell transformation.
Topics: Avian Sarcoma Viruses; Cell Transformation, Viral; Epidermal Growth Factor; Escherichia coli; Gene Expression Regulation; Oncogene Protein pp60(v-src); Phosphoprotein Phosphatases; Phosphotyrosine; Protein Kinases; Tyrosine; Viral Proteins | 1983 |
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Transformation, Viral; Cells, Cultured; Epidermal Growth Factor; Humans; Mice; Phosphoproteins; Phosphotyrosine; Protein Kinases; Tyrosine | 1983 |
Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3).
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Immunoglobulin M; Phosphotyrosine; Pituitary Gland; Prolactin; Rats; Receptors, Cell Surface; Tyrosine | 1983 |
Purification of the receptor for epidermal growth factor from A-431 cells: its function as a tyrosyl kinase.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Weight; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Radioisotope Dilution Technique; Receptors, Cell Surface; Tyrosine | 1983 |
Comparison of protein phosphorylations in variant A431 cells with different growth responses to epidermal growth factor.
Topics: Cell Line; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Receptors, Cell Surface; Tyrosine | 1984 |
The proteins of oncogenes.
Topics: Animals; Annexins; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA; Epidermal Growth Factor; ErbB Receptors; Guanosine Triphosphate; Humans; Membrane Proteins; Neoplasm Proteins; Nucleoproteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Cell Surface; Retroviridae; Tyrosine; Viral Proteins | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Abelson murine leukaemia virus transformation involves loss of epidermal growth factor-binding sites.
Topics: Abelson murine leukemia virus; Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Epidermal Growth Factor; Leukemia Virus, Murine; Mink; Peptides; Phosphoproteins; Protein Kinases; Rats; Receptors, Cell Surface; Tyrosine | 1980 |
Anti-pp60src antibodies are substrates for EGF-stimulated protein kinase.
Topics: Antibodies, Neoplasm; Carcinoma; Cross Reactions; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Oncogene Protein pp60(v-src); Peptides; Phosphoproteins; Phosphorylation; Protein Kinases; Receptors, Cell Surface; Tyrosine; Viral Proteins | 1981 |
Human transforming growth factors induce tyrosine phosphorylation of EGF receptors.
Topics: Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Humans; Peptides; Phosphorylation; Protein Kinases; Receptors, Cell Surface; Transforming Growth Factors; Tyrosine | 1981 |
Solubilization of EGF receptor with Triton X-100 alters stimulation of tyrosine residue phosphorylation by EGF and dimethyl sulfoxide.
Topics: Animals; Dimethyl Sulfoxide; Epidermal Growth Factor; ErbB Receptors; Liver; Male; Octoxynol; Phosphorylation; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Solubility; Tyrosine | 1983 |
Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Chickens; Epidermal Growth Factor; ErbB Receptors; Gizzard, Avian; Humans; Kinetics; Muscle, Smooth; Myosins; Phosphorylation; Protein Kinases; Receptors, Cell Surface; Tyrosine | 1983 |
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism.
Topics: Adenosine Triphosphate; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Weight; Peptide Fragments; Phorbols; Phosphorus Radioisotopes; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
Topics: Amino Acids; Carcinogens; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Phorbol Esters; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Tyrosine | 1984 |
Stimulation of tyrosine phosphorylation by platelet-derived growth factor.
Topics: Adenosine Triphosphate; Animals; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblasts; Molecular Weight; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Protein-Tyrosine Kinases; Tyrosine | 1984 |
Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts.
Topics: Animals; Chick Embryo; Epidermal Growth Factor; Fibroblasts; Growth Substances; Insulin-Like Growth Factor II; Mitogens; Molecular Weight; Peptides; Phosphorylation; Platelet-Derived Growth Factor; Proteins; Tyrosine | 1983 |
DMSO increases tyrosine residue phosphorylation in membranes from murine erythroleukemia cells.
Topics: Animals; Cell Membrane; Dimethyl Sulfoxide; Epidermal Growth Factor; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phosphorylation; Tyrosine | 1983 |
Synthetic peptide substrates for the membrane tyrosine protein kinase stimulated by epidermal growth factor.
Topics: Amino Acid Sequence; Cell Line; Cell Membrane; Epidermal Growth Factor; Hydrogen-Ion Concentration; Kinetics; Peptides; Phosphorylation; Protein Kinases; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1984 |
Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.
Topics: Adenosine Triphosphate; Cations, Divalent; Cell Membrane; Epidermal Growth Factor; Female; Humans; Insulin; Kinetics; Phosphorylation; Placenta; Pregnancy; Receptor, Insulin; Tyrosine | 1982 |
Epidermal growth factor-stimulated phosphorylation of tyrosine residues on a 120 000 dalton protein in mouse liver plasma membrane subfractions.
Topics: Animals; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Female; Liver; Membrane Proteins; Mice; Molecular Weight; Phosphorylation; Tyrosine | 1981 |
Changes in the proteins of wool following treatment of sheep with epidermal growth factor.
Topics: Animals; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Hair; Infusions, Parenteral; Male; Mice; Protein Biosynthesis; Proteins; Sheep; Sulfur; Time Factors; Tyrosine | 1982 |
Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Humans; Kinetics; Melanoma; Membrane Proteins; Mice; Peptides; Phosphorylation; Transforming Growth Factors; Tyrosine | 1982 |
Protein kinase C mediates short- and long-term effects on receptor tyrosine kinases. Regulation of tyrosine phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Homeostasis; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyanogen Bromide; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Trypsin; Tyrosine | 1995 |
Shc is a substrate of the rat intestinal epidermal growth factor receptor tyrosine kinase.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Immunoblotting; Intestinal Mucosa; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Rats; src Homology Domains; Tyrosine | 1995 |
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins.
Topics: Amino Acid Sequence; B-Lymphocytes; Base Sequence; Binding Sites; Cell Line; Epidermal Growth Factor; Glutathione Transferase; Humans; Interferon-alpha; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1993 |
Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line.
Topics: Animals; Becaplermin; Cell Line; Enzyme Activation; Epidermal Growth Factor; Flow Cytometry; Humans; Interleukin-2; Isoenzymes; Kinetics; Mice; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Receptors, Antigen, T-Cell; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; T-Lymphocytes; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal growth factor receptor into the nucleus.
Topics: Amino Acid Sequence; Cell Fractionation; Cell Nucleus; Epidermal Growth Factor; Epitopes; ErbB Receptors; Humans; Microscopy, Immunoelectron; Molecular Sequence Data; Nuclear Proteins; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine | 1994 |
Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.
Topics: 3T3 Cells; Animals; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor induces acrosomal exocytosis in bovine sperm.
Topics: Acrosome; Animals; Bucladesine; Calcimycin; Calcium; Cattle; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Male; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Insulin; Membrane Proteins; Molecular Weight; Nerve Growth Factors; Neurons; Oncogene Protein v-crk; Paxillin; PC12 Cells; Phosphoproteins; Phosphotyrosine; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Receptors, Nerve Growth Factor; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 1994 |
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.
Topics: Amino Acid Sequence; Animals; Antibodies; Cell Line; Cell Transformation, Neoplastic; Culture Media; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, src; Immunoblotting; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Tyrosine | 1994 |
Preferential inhibition of platelet-derived growth factor-stimulated DNA synthesis and protein tyrosine phosphorylation by nordihydroguaiaretic acid.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cell Line; Cell Nucleus; Cells, Cultured; Dinoprostone; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Masoprocol; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Skin; Thymidine; Tyrosine | 1994 |
Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors.
Topics: Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Glycogen Synthase Kinase 3; In Vitro Techniques; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tyrosine | 1994 |
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Baculoviridae; Binding Sites; Breast; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Moths; Oligopeptides; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-3; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor (scatter factor/hepatocyte growth factor receptor).
Topics: Animals; Base Sequence; Cell Movement; Cells, Cultured; Epidermal Growth Factor; Hepatocyte Growth Factor; Ligands; Mice; Molecular Sequence Data; Myelin Basic Protein; Phosphorylation; Point Mutation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Transfection; Tyrosine | 1994 |
Presence of growth factors in palmar and plantar fibromatoses.
Topics: Adult; Epidermal Growth Factor; Female; Fibroma; Fibronectins; Foot Dermatoses; Growth Substances; Hand Dermatoses; Humans; Immunohistochemistry; Male; Middle Aged; Phosphotyrosine; Procollagen; Transforming Growth Factor beta; Tyrosine | 1994 |
Epidermal growth factor-induced mitogen signals in cultured intestinal epithelial cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Epithelium; Jejunum; Mitogens; Molecular Weight; Phosphorylation; Phosphotyrosine; Proteins; Rats; Tyrosine | 1994 |
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Topics: Base Sequence; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, fos; Humans; Microcirculation; Molecular Sequence Data; Nuclear Proteins; Omentum; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; DNA; Enzyme Activation; Epidermal Growth Factor; Growth Inhibitors; Humans; In Vitro Techniques; Interferons; Isoenzymes; Mice; Molecular Sequence Data; Oligonucleotide Probes; Phorbol Esters; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Signal Transduction; Tyrosine | 1994 |
Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms.
Topics: Breast Neoplasms; Cell Division; Down-Regulation; Epidermal Growth Factor; Estradiol; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; In Vitro Techniques; Phosphotyrosine; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells.
Topics: Animals; Base Sequence; Binding Sites; Caseins; Cell Line; Cells, Cultured; Cytokines; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Epithelial Cells; Glucocorticoids; Insulin; Lactation; Macrophages; Mammary Glands, Animal; Mice; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Sequence Homology, Nucleic Acid; STAT5 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
Nitric oxide stimulates tyrosine phosphorylation in murine fibroblasts in the absence and presence of epidermal growth factor.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Methylene Blue; Mice; Nitric Oxide; Nitroprusside; Oxidation-Reduction; Oxyhemoglobins; Penicillamine; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; S-Nitroso-N-Acetylpenicillamine; Tyrosine | 1995 |
Regulation of vascular and gastric smooth muscle contractility by pervanadate.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blotting, Western; Calcium; Epidermal Growth Factor; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sodium; Stomach; Tyrosine; Vanadates | 1994 |
Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells.
Topics: Animals; Asbestos, Crocidolite; Blotting, Northern; Cell Division; Cell Line; Cell Line, Transformed; Epidermal Growth Factor; ErbB Receptors; Mesothelioma; Peritoneal Neoplasms; Phosphoproteins; Phosphotyrosine; Radioimmunoassay; Rats; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1995 |
Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line.
Topics: alpha Catenin; Benzoquinones; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Aggregation; Cell Line; Culture Techniques; Cytoskeletal Proteins; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Fibroblasts; Fluorescent Antibody Technique; Gels; Humans; Lactams, Macrocyclic; Neoplasm Invasiveness; Neoplasm Proteins; Phenotype; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Quinones; Rifabutin; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrosine; Vanadates | 1995 |
Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6).
Topics: Animals; Cell Count; Cell Division; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Genistein; Inositol Phosphates; Intestinal Mucosa; Isoenzymes; Isoflavones; Membrane Proteins; Phospholipase C gamma; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Time Factors; Type C Phospholipases; Tyrosine | 1995 |
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Glycoproteins; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Kinetics; Neuregulins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Lactation; Mice; Mice, Mutant Strains; Molecular Sequence Data; Phosphotyrosine; Point Mutation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1995 |
Tyrosine phosphorylation in the human duodenum.
Topics: CD3 Complex; Celiac Disease; Duodenum; Edetic Acid; Epidermal Growth Factor; Flow Cytometry; Humans; Immunoenzyme Techniques; Phosphorylation; Phosphotyrosine; Tyrosine | 1995 |
Staurosporine causes epidermal growth factor to induce differentiation in PC12 cells via receptor up-regulation.
Topics: Alkaloids; Animals; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; RNA, Messenger; Staurosporine; Tyrosine; Up-Regulation | 1995 |
Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion.
Topics: Animals; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunohistochemistry; Kinetics; Mice; Phosphotyrosine; Placenta; Placental Lactogen; Pregnancy; Rats; Recombinant Proteins; Transforming Growth Factor alpha; Tyrosine | 1995 |
Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cesarean Section; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Kinetics; Myometrium; Oxytocin; Phosphorylation; Phosphotyrosine; Postpartum Period; Pregnancy; Ritodrine; Tyrosine | 1995 |
Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites.
Topics: Animals; Cell Division; Cell Line, Transformed; Cricetinae; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Linoleic Acid; Linoleic Acids; Mesocricetus; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1995 |
Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.
Topics: Animals; Base Sequence; Caseins; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; Liver; Mice; Milk Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Phosphotyrosine; Prolactin; Promoter Regions, Genetic; Protein Processing, Post-Translational; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; DNA; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Indomethacin; Kinetics; Liver; Male; Phospholipases A; Phospholipases A2; Phosphotyrosine; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 1995 |
Insulin-like growth factor-1 enhances epidermal growth factor receptor activation and renal tubular cell regeneration in postischemic acute renal failure.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Blood Pressure; Body Weight; DNA; Epidermal Growth Factor; ErbB Receptors; Insulin-Like Growth Factor I; Iodine Radioisotopes; Ischemia; Kidney Medulla; Kidney Tubules; Male; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Regeneration; Renal Circulation; Tyrosine | 1995 |
Analysis of phosphorylhydroxyamino acids present in hydrolyzed cell extracts using dabsyl derivatization.
Topics: Cell Extracts; Chromatography, Thin Layer; Electrophoresis; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; p-Dimethylaminoazobenzene; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Protein-Tyrosine Kinases; Quercetin; Tumor Cells, Cultured; Tyrosine | 1995 |
Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta.
Topics: Blotting, Western; Cell Membrane; Cell Nucleus; Choriocarcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunoenzyme Techniques; Immunosorbent Techniques; Microscopy, Immunoelectron; Nuclear Envelope; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Receptors, LH; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1995 |
Insulin stimulates the tyrosine phosphorylation of caveolin.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Blotting, Western; Caveolin 1; Caveolins; Epidermal Growth Factor; Insulin; Kinetics; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Polyethylene Glycols; Protein Binding; Protein-Tyrosine Kinases; Tyrosine | 1995 |
Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein.
Topics: 3T3 Cells; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1995 |
Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.
Topics: Actins; Blotting, Western; Carcinoma, Squamous Cell; Cell Line; Cytochalasin D; Epidermal Growth Factor; Humans; Intercellular Junctions; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tumor Cells, Cultured; Tyrosine; Zonula Occludens-1 Protein | 1995 |
Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH.
Topics: alpha-Macroglobulins; Animals; Cells, Cultured; Cytosol; Epidermal Growth Factor; Genistein; Humans; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Isoenzymes; Isoflavones; Lactoferrin; Low Density Lipoprotein Receptor-Related Protein-1; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Phospholipase C gamma; Phosphorylation; Rats; Receptors, Immunologic; Type C Phospholipases; Tyrosine | 1995 |
Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor.
Topics: Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, src; Immunoblotting; Mammary Neoplasms, Animal; Mice; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
Effects of growth factors on phosphatidylinositol-3 kinase in astroglial cells.
Topics: Animals; Astrocytes; Epidermal Growth Factor; Growth Substances; Insulin-Like Growth Factor I; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 1995 |
UV activation of receptor tyrosine kinase activity.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Insulin; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinase 1; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptor, Insulin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Ultraviolet Rays | 1995 |
PC12-E2 cells: a stable variant with altered responses to growth factor stimulation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression; Growth Substances; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurites; PC12 Cells; Phosphotyrosine; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; RNA, Messenger; Transcription, Genetic; Tyrosine | 1995 |
Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cricetinae; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Isoenzymes; Kinetics; Mice; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Receptor, Insulin; Recombinant Proteins; Substrate Specificity; Transfection; Tyrosine | 1995 |
Inhibition by 5'-methylthioadenosine of cell growth and tyrosine kinase activity stimulated by fibroblast growth factor receptor in human gliomas.
Topics: Antibodies; Cell Division; Cell Line; Cell Nucleus; Cross-Linking Reagents; Deoxyadenosines; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factor 2; Glioblastoma; Glioma; Humans; Immunoblotting; Iodine Radioisotopes; Methyltransferases; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Thionucleosides; Tyrosine | 1995 |
Specificity of nerve growth factor signaling: differential patterns of early tyrosine phosphorylation events induced by NGF, EGF, and bFGF.
Topics: 3T3 Cells; Animals; Epidermal Growth Factor; Fibroblast Growth Factor 2; Isoenzymes; Mice; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptor, trkA; Signal Transduction; Type C Phospholipases; Tyrosine | 1995 |
Effects of trapidil and suramin on growth factor-induced calcium response and tyrosine phosphorylation in human glioma cells.
Topics: Antineoplastic Agents; Calcium; Cell Division; Epidermal Growth Factor; Glioblastoma; Humans; Phosphorylation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Suramin; Trapidil; Tumor Cells, Cultured; Tyrosine | 1995 |
Insulin-like growth factor-II as a paracrine growth factor in human neuroblastoma cells.
Topics: Base Sequence; Blotting, Northern; Cell Division; Epidermal Growth Factor; Gene Expression; Humans; Insulin-Like Growth Factor II; Molecular Sequence Data; Neuroblastoma; Phosphorylation; Receptor, IGF Type 1; Receptor, IGF Type 2; Tumor Cells, Cultured; Tyrosine | 1995 |
A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Aurintricarboxylic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Culture Media, Serum-Free; Deoxyribonucleases; Enzyme Activation; Epidermal Growth Factor; Isoenzymes; Mice; Nerve Growth Factors; Neurons; PC12 Cells; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rats; Ribonucleases; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases; Tyrosine | 1995 |
[(Alkylamino)methyl]acrylophenones: potent and selective inhibitors of the epidermal growth factor receptor protein tyrosine kinase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Ketones; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Structure-Activity Relationship; Tyrosine | 1995 |
Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Neuregulins; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptor, ErbB-3; Tyrosine | 1995 |
Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Line; Enzyme Activation; Epidermal Growth Factor; GRB2 Adaptor Protein; GTP-Binding Proteins; Membrane Proteins; Phosphorylation; Protein Kinases; Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Son of Sevenless Proteins; Tyrosine | 1995 |
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
Topics: Animals; Caenorhabditis elegans; Cell Line; Epidermal Growth Factor; ErbB Receptors; Glutathione Transferase; Humans; Mice; Mutagenesis; Phosphorylation; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogenes; Recombinant Fusion Proteins; Retroviridae; Sequence Deletion; Signal Transduction; Transfection; Tyrosine; Ubiquitin-Protein Ligases | 1995 |
Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.
Topics: Amino Acid Sequence; Binding Sites; Binding, Competitive; Conserved Sequence; Epidermal Growth Factor; ErbB Receptors; Humans; Immunosorbent Techniques; Kinetics; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Recombinant Fusion Proteins; Type C Phospholipases; Tyrosine | 1993 |
Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Mitogens; Molecular Sequence Data; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1993 |
O-phospho-L-tyrosine inhibits cellular growth by activating protein tyrosine phosphatases.
Topics: Breast Neoplasms; Carcinoma, Renal Cell; Cell Death; Cell Division; Doxorubicin; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Etoposide; Humans; Kidney Neoplasms; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Tyrosine | 1993 |
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Exogenous phosphotyrosine modulates epidermal growth factor receptor tyrosine phosphorylation.
Topics: Breast Neoplasms; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Egtazic Acid; Epidermal Growth Factor; Immunoblotting; Insulin; Kinetics; Mice; Muscles; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Cell-free activation of a DNA-binding protein by epidermal growth factor.
Topics: 3T3 Cells; Animals; Cell Fractionation; Cell Line; Cell Membrane; Cell Nucleus; Cell-Free System; Cytosol; Dithiothreitol; DNA-Binding Proteins; Drosophila melanogaster; Epidermal Growth Factor; Genes, fos; Humans; Mice; Phosphotyrosine; Signal Transduction; Transcription, Genetic; Tyrosine; Ultracentrifugation | 1993 |
Gi alpha and Gi beta are part of a signalling complex in Balb/c3T3 cells: phosphorylation of Gi beta in growth-factor-activated fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Insulin; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Virulence Factors, Bordetella | 1993 |
Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse.
Topics: Animals; Animals, Newborn; Carrier Proteins; Cell Membrane; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Kinetics; Liver; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Tyrosine | 1993 |
Protein kinases in divergent eukaryotes: identification of protein kinase activities regulated during trypanosome development.
Topics: Animals; Epidermal Growth Factor; Giardia lamblia; Humans; Isoenzymes; Kinetics; Phosphotyrosine; Protein Denaturation; Protein Kinases; Species Specificity; Trichomonas vaginalis; Trypanosoma brucei brucei; Tumor Cells, Cultured; Tyrosine | 1993 |
Role of intracellular Ca2+ in the epidermal growth factor induced inhibition of protein tyrosine phosphatase activity in a breast cancer cell line.
Topics: Breast Neoplasms; Calcium; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Phosphoproteins; Phosphotyrosine; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine | 1993 |
Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells.
Topics: Animals; Blotting, Western; Bronchi; Cell Division; Cell Line; Epidermal Growth Factor; Epithelium; Gene Expression; Humans; In Vitro Techniques; Ki-67 Antigen; Ligands; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tyrosine | 1993 |
Inhibition of EGF-induced vasoconstriction in isolated rabbit aortic rings with the tyrosine kinase inhibitor RG50864.
Topics: Animals; Aorta, Abdominal; Catechols; Dose-Response Relationship, Drug; Epidermal Growth Factor; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tyrosine; Tyrphostins; Vasoconstriction | 1993 |
Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Ethers, Cyclic; Gene Expression; Genes, fos; Glycosylation; Guanosine Triphosphate; Insulin; Nerve Growth Factors; Okadaic Acid; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Phosphotyrosine; Protein Kinases; Proto-Oncogene Proteins p21(ras); Rats; Receptor, Insulin; Signal Transduction; Tyrosine | 1993 |
Changes of the phosphorylation of membrane-associated proteins following treatment of HeLa cells with the guanine analogue, queuine.
Topics: Adenosine Triphosphate; Epidermal Growth Factor; Guanine; HeLa Cells; Humans; Membrane Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction; Tyrosine | 1993 |
The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Aggregation; Cell Movement; Cell Size; Epidermal Growth Factor; ErbB Receptors; Genistein; Hepatocyte Growth Factor; Isoflavones; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 1993 |
Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes.
Topics: Arachidonic Acid; Cells, Cultured; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Hydrolysis; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Keratinocytes; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylcholines; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Kinase C; Proteins; Transforming Growth Factor alpha; Type C Phospholipases; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growth Factor; Humans; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Inhibitory effects of alpha-interferon on epidermal growth factor-mediated receptor-dependent events.
Topics: Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescein-5-isothiocyanate; Glioblastoma; Humans; Interferon Type I; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Recombinant Proteins; RNA, Neoplasm; Tumor Cells, Cultured; Tyrosine | 1993 |
[The correlation between epidermal growth factor (EGF) binding with receptors and the tyrosine phosphorylation of the EGF receptors in the plasma membrane and in the endosomes].
Topics: Carcinoma, Squamous Cell; Cell Membrane; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Ligands; Membrane Proteins; Phosphorylation; Precipitin Tests; Protein Binding; Tumor Cells, Cultured; Tyrosine | 1994 |
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.
Topics: Angiotensin II; Animals; Aorta; Cell Line; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; Humans; Interferon-gamma; Janus Kinase 2; Muscle, Smooth, Vascular; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptors, Angiotensin; STAT1 Transcription Factor; STAT2 Transcription Factor; Trans-Activators; Tyrosine | 1995 |
Interleukin-1 modulates phosphorylation of proteins in human osteoblastic cells.
Topics: Bone Neoplasms; Bone Resorption; Cell Division; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblast Growth Factor 2; Fibroblasts; Humans; Interleukin-1; Osteoblasts; Osteosarcoma; Phosphorylation; Platelet-Derived Growth Factor; Proteins; Receptors, Growth Factor; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1995 |
HER4 receptor activation and phosphorylation of Shc proteins by recombinant heregulin-Fc fusion proteins.
Topics: Amino Acid Sequence; Animals; Base Sequence; Breast Neoplasms; Cells, Cultured; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Humans; Immunoglobulin Fc Fragments; Intercellular Adhesion Molecule-1; Molecular Sequence Data; Neuregulins; Phosphorylation; Protein Binding; Receptor, ErbB-4; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Thrombin; Tyrosine | 1995 |
Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cell Line; Cloning, Molecular; DNA, Complementary; Epidermal Growth Factor; Humans; In Situ Hybridization; Molecular Sequence Data; Motor Neurons; Nerve Tissue Proteins; Neuregulin-1; Neurons, Afferent; Phosphorylation; Rats; Receptor, ErbB-2; RNA, Messenger; Sequence Homology, Amino Acid; Tyrosine | 1995 |
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Oncogene Protein p21(ras); Phosphorylation; Proteins; Rats; Signal Transduction; Tyrosine | 1994 |
Depolarization-induced tyrosine phosphorylation in PC12h cells.
Topics: Animals; Blotting, Western; Calcium; Epidermal Growth Factor; Fibroblast Growth Factors; Membrane Potentials; Nerve Growth Factors; PC12 Cells; Phosphorylation; Potassium Chloride; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Tyrosine | 1994 |
Effects of epidermal growth factor on the tyrosine phosphorylation of mitogen-activated protein kinases in monolayer cultures of porcine granulosa cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Female; Granulosa Cells; Osmolar Concentration; Phosphorylation; Swine; Time Factors; Tyrosine | 1995 |
Epidermal growth factor induces protein tyrosine phosphorylation and association of p190 with ras-GTP-ase activating protein in Caco-2 cells.
Topics: Antibodies; Blotting, Western; Epidermal Growth Factor; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Nuclear Proteins; Phosphoproteins; Phosphorylation; Proteins; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; ras-GRF1; Receptor, ErbB-2; Repressor Proteins; Tumor Cells, Cultured; Tyrosine | 1994 |
Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; beta Catenin; Cadherins; Cell Line; Cell Polarity; Cytoskeletal Proteins; Desmoplakins; Epidermal Growth Factor; ErbB Receptors; gamma Catenin; Humans; Molecular Sequence Data; Phosphorylation; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine.
Topics: Aging; Animals; Blotting, Western; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Intestine, Small; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Proteins; ras GTPase-Activating Proteins; Rats; Rats, Wistar; Signal Transduction; Type C Phospholipases; Tyrosine; Weaning | 1994 |
Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Collagen; Epidermal Growth Factor; ErbB Receptors; GTPase-Activating Proteins; Mice; Phosphorylation; Proteins; ras GTPase-Activating Proteins; Transfection; Type C Phospholipases; Tyrosine | 1994 |
Melittin inhibits epidermal growth factor-induced protein tyrosine phosphorylation: comparison with phorbol myristate acetate and calcium ionophore A23187.
Topics: 3T3 Cells; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Dimethyl Sulfoxide; Epidermal Growth Factor; Melitten; Mice; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Increased levels and constitutive tyrosine phosphorylation of the epidermal growth factor receptor contribute to autonomous growth of human papillomavirus type 16 immortalized human keratinocytes.
Topics: Antibodies, Monoclonal; Cell Division; Cell Line, Transformed; Culture Media, Conditioned; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Kinetics; Neutralization Tests; Papillomaviridae; Phosphorylation; Skin; Transforming Growth Factor alpha; Tyrosine | 1994 |
A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.
Topics: Animals; Base Sequence; Blotting, Western; DNA-Binding Proteins; Epidermal Growth Factor; Lipopolysaccharides; Liver; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Precipitin Tests; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1994 |
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.
Topics: alpha Catenin; beta Catenin; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Desmoplakins; Epidermal Growth Factor; gamma Catenin; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Phosphorylation; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1994 |
Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Polarity; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Hormones; Kidney Medulla; Kidney Tubules, Collecting; Muscarine; Peptides; Phosphorylation; Purines; Rats; Tyrosine; Vasopressins | 1994 |
Orogastric EGF enhances c-neu and EGF receptor phosphorylation in suckling rat jejunum in vivo.
Topics: Administration, Oral; Animals; Animals, Suckling; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Intubation, Gastrointestinal; Jejunum; Phosphorylation; Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Tyrosine | 1993 |
Effect of ebrotidine on gastric mucosal EGF and PDGF receptor expression.
Topics: Animals; Benzenesulfonates; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Gastric Mucosa; Histamine H2 Antagonists; Phosphorylation; Platelet-Derived Growth Factor; Ranitidine; Rats; Receptors, Platelet-Derived Growth Factor; Thiazoles; Tyrosine | 1993 |
Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes.
Topics: Actins; Animals; Biological Transport; Cells, Cultured; Cytoskeleton; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Isoenzymes; Liver; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Tyrosine | 1994 |
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Humans; Interferon-gamma; Interleukin-6; Mice; Molecular Sequence Data; Phosphorylation; Regulatory Sequences, Nucleic Acid; Sequence Alignment; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Aspartic Acid; Betacellulin; Cell Division; Cell Line; Chromatography, Affinity; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Culture Media, Conditioned; Epidermal Growth Factor; ErbB Receptors; Female; Glycosylation; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Differential signal transduction of epidermal-growth-factor receptors in hormone-dependent and hormone-independent human breast cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Cell Division; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Fluorescein-5-isothiocyanate; Genes, fos; Humans; Neoplasms, Hormone-Dependent; Phosphorylation; Proto-Oncogene Mas; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1994 |
Brush-border tyrosine phosphorylation stimulates ileal neutral NaCl absorption and brush-border Na(+)-H+ exchange.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Calcimycin; Epidermal Growth Factor; Genistein; Ileum; Intestinal Absorption; Isoflavones; Male; Microvilli; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Serous Membrane; Sodium Chloride; Sodium-Hydrogen Exchangers; Tyrosine | 1994 |
The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X.
Topics: Amino Acid Sequence; Aspartic Acid; Calcium; Calcium-Binding Proteins; Epidermal Growth Factor; Factor IX; Factor X; Humans; Hydroxylation; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Protein Structure, Tertiary; Structure-Activity Relationship; Tyrosine | 1993 |
RAS is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts.
Topics: Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gene Expression Regulation; Genes, ras; Mutation; Phospholipases A; Phospholipases A2; Phosphorylation; Precipitin Tests; Rats; Tetradecanoylphorbol Acetate; Transfection; Tritium; Tyrosine | 1993 |
Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors.
Topics: Catechols; Cell Division; DNA, Neoplasm; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Immunoblotting; Nitriles; Pancreatic Ducts; Pancreatic Neoplasms; Phenols; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1993 |
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.
Topics: Adenylate Cyclase Toxin; Alkaloids; Animals; Cell Adhesion Molecules; Cells, Cultured; Endothelins; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Kinetics; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Oncogene Protein p21(ras); Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Tyrosine; Virulence Factors, Bordetella | 1994 |
Interaction of activated EGF receptors with coated pit adaptins.
Topics: Adaptor Protein Complex alpha Subunits; Adaptor Proteins, Vesicular Transport; Coated Pits, Cell-Membrane; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Potassium; Proteins; Temperature; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine 69 of the first epidermal growth factor-like domain of human factor IX is essential for clotting activity.
Topics: Amino Acid Sequence; Base Sequence; Blood Coagulation; Calcium; Chromatography, Affinity; Disulfides; Epidermal Growth Factor; Factor IX; Factor IXa; Factor X; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Structural; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Conformation; Recombinant Proteins; Tyrosine | 1993 |
Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei.
Topics: Animals; Base Sequence; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; Genes, fos; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Liver; Mice; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1993 |
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Growth Substances; Humans; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Macrophage Colony-Stimulating Factor; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Platelet-Derived Growth Factor; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1993 |
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphorylation; Protein Kinase C; Protein Kinases; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1993 |
Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Division; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Mice; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Recombinant Proteins; Signal Transduction; Thymidine; Transfection; Tyrosine | 1993 |
Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Arginine Vasopressin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Culture Media, Serum-Free; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Kinetics; Mice; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Threonine; Tyrosine; Virulence Factors, Bordetella | 1993 |
Mucus glycoprotein regulation of gastric mucosal calcium channel activity.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Calcium; Calcium Channels; Epidermal Growth Factor; Gastric Acid; Gastric Mucosa; Humans; Mucins; Phosphorylation; Rats; Tyrosine | 1993 |
Modulation of gastric mucosal calcium channel activity by mucus glycoprotein.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Epidermal Growth Factor; Gastric Mucosa; Genistein; Glycoproteins; Humans; In Vitro Techniques; Isoflavones; Male; Mucus; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrosine | 1993 |
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Humans; Kinetics; L Cells; Ligands; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Deletion; Transfection; Tyrosine | 1993 |
Bradykinin inhibition of EGF- and PDGF-induced DNA synthesis in human fibroblasts.
Topics: Bradykinin; Calcium; Cells, Cultured; Dinoprostone; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Phosphatidylinositols; Phosphorylation; Platelet-Derived Growth Factor; Signal Transduction; Time Factors; Tyrosine | 1993 |
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors.
Topics: Base Sequence; Cell Nucleus; Cytokines; DNA-Binding Proteins; Epidermal Growth Factor; Growth Substances; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-6; Molecular Sequence Data; Phosphorylation; Receptors, Cell Surface; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrosine | 1993 |
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Mice; Phosphorylation; Proteins; Receptor, Insulin; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1993 |
Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis.
Topics: 3T3 Cells; Animals; Cytoskeleton; Epidermal Growth Factor; ErbB Receptors; Flavanones; Flavonoids; Inositol Phosphates; Mice; Phosphorylation; Plants; Protein-Tyrosine Kinases; Tyrosine; X-Ray Diffraction | 1993 |
The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal growth factor in receptor binding.
Topics: Amino Acid Sequence; Base Sequence; Binding, Competitive; Circular Dichroism; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Conformation; Recombinant Proteins; Tyrosine | 1993 |
Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation.
Topics: Anticarcinogenic Agents; Catechols; Cell Division; Epidermal Growth Factor; ErbB Receptors; Estrogens, Non-Steroidal; Genistein; Humans; Isoflavones; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 1993 |
Epidermal growth factor induces serine phosphorylation of stathmin in a human colon carcinoma cell line (LIM 1215).
Topics: Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; Microtubule Proteins; Molecular Sequence Data; Oligonucleotides, Antisense; Peptide Mapping; Phosphoproteins; Phosphorylation; Serine; Stathmin; Tumor Cells, Cultured; Tyrosine | 1993 |
Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.
Topics: Animals; Cytoskeletal Proteins; Cytoskeleton; Detergents; Epidermal Growth Factor; Humans; Mice; Microvilli; Morphogenesis; Octoxynol; Phosphoproteins; Phosphorylation; Placenta; Placentation; Solubility; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine phosphorylation of phospholipase C-gamma 1 by vaccinia virus growth factor.
Topics: 3T3 Cells; Animals; Enzyme Activation; Epidermal Growth Factor; Growth Substances; HeLa Cells; Humans; Inositol Phosphates; Intercellular Signaling Peptides and Proteins; Isoenzymes; Mice; Peptides; Phospholipase C gamma; Phosphorylation; Platelet-Derived Growth Factor; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Vaccinia virus; Viral Proteins | 1995 |
Protein tyrosine phosphorylation induced by epidermal growth factor and insulin-like growth factor-I in a rat clonal dental pulp-cell line.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Clone Cells; Dental Pulp; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isoflavones; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signalling in cultured rat cerebral cortical neurons.
Topics: Animals; Antibodies; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Immunohistochemistry; Male; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Time Factors; Tyrosine | 1995 |
The epidermal growth factor receptor is covalently linked to ubiquitin.
Topics: Animals; CHO Cells; Cold Temperature; Cricetinae; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Sheep; Tyrosine; Ubiquitins | 1995 |
Increased activation of EGF-receptor tyrosine kinase by EGF and TGF-alpha in the colonic mucosa of aged rats.
Topics: Aging; Animals; Bombesin; Colon; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; In Vitro Techniques; Intestinal Mucosa; Male; Phosphorylation; Rats; Rats, Inbred F344; Transforming Growth Factor alpha; Tyrosine | 1996 |
p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.
Topics: Animals; Cell Line; Epidermal Growth Factor; Glutathione Transferase; Kinetics; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rats; Recombinant Fusion Proteins; Tyrosine; Ubiquitin-Protein Ligases | 1996 |
Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2.
Topics: Base Sequence; Breast; Breast Neoplasms; Cell Division; Epidermal Growth Factor; Female; Gene Amplification; Genes, erbB-2; Glycoproteins; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Neuregulins; Phosphorylation; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1996 |
Hepatocyte growth factor (HGF)-induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor.
Topics: Carcinoma; Cell Movement; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Phosphorylation; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Stomach Neoplasms; Tumor Cells, Cultured; Tyrosine | 1996 |
HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Cell Division; Epidermal Growth Factor; ErbB Receptors; Humans; Macromolecular Substances; Mice; Molecular Sequence Data; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, ErbB-4; Recombinant Fusion Proteins; Recombinant Proteins; Substrate Specificity; Transfection; Tyrosine | 1996 |
Enhanced modulation of keratinocyte motility by transforming growth factor-alpha (TGF-alpha) relative to epidermal growth factor (EGF).
Topics: Cell Movement; Cells, Cultured; DNA; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Phosphorylation; Transforming Growth Factor alpha; Tyrosine; Wound Healing | 1996 |
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
Topics: Alleles; Aluminum Compounds; Animals; Animals, Newborn; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Fluorides; Gene Expression; Genes, ras; GTP-Binding Proteins; Isoenzymes; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Proteins; Signal Transduction; Spodoptera; Transfection; Transforming Growth Factor alpha; Tyrosine | 1996 |
STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1.
Topics: Amphiregulin; Animals; Cell Line; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Interferon-gamma; Janus Kinase 1; Mice; Phosphorylation; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Signal Transduction; Transcription Factors; Transfection; Tyrosine | 1996 |
Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities.
Topics: Animals; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; In Vitro Techniques; Neuregulins; Peptides; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Tumor Cells, Cultured; Tyrosine | 1996 |
Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Cell Differentiation; Crk-Associated Substrate Protein; Epidermal Growth Factor; ErbB Receptors; Molecular Sequence Data; Nerve Growth Factors; Oncogene Protein v-crk; PC12 Cells; Peptide Fragments; Pheochromocytoma; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteins; Rats; Recombinant Fusion Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Tyrosine | 1996 |
Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin.
Topics: 3T3 Cells; Androstadienes; Animals; Bombesin; Cell Adhesion Molecules; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mutagenesis, Site-Directed; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet-Derived Growth Factor; Point Mutation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Tyrosine; Wortmannin | 1996 |
Protein-tyrosine phosphatase-mediated decrease of epidermal growth factor and platelet-derived growth factor receptor tyrosine phosphorylation in high cell density cultures.
Topics: Animals; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Kinetics; Mink; Phosphorylation; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Radioligand Assay; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Swine; Tyrosine | 1996 |
Ligand activation of overexpressed epidermal growth factor receptor results in colony dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous carcinoma cells.
Topics: beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Division; Cell Size; Collagen; Cytoskeletal Proteins; Detergents; Epidermal Growth Factor; ErbB Receptors; Humans; Octoxynol; Phosphorylation; Skin Neoplasms; Solubility; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1996 |
c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Line, Transformed; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; GRB2 Adaptor Protein; Humans; Leukemia; Mice; Oncogene Protein pp60(v-src); Phosphorylation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; src Homology Domains; Tumor Cells, Cultured; Tyrosine; Ubiquitin-Protein Ligases | 1995 |
Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Epidermal Growth Factor; GRB2 Adaptor Protein; Humans; Osmotic Pressure; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Temperature; Tyrosine | 1996 |
Inhibition of PDGF-induced phosphoinositide-turnover by glucopiericidin A.
Topics: 3T3 Cells; Aminoglycosides; Animals; Anti-Bacterial Agents; Carcinoma; Epidermal Growth Factor; Humans; Immunoblotting; Isoenzymes; Mice; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Receptors, Platelet-Derived Growth Factor; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1995 |
Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
Topics: 3T3 Cells; Animals; CHO Cells; Cricetinae; Cysteine; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Mice; Mitogen-Activated Protein Kinase Kinases; Mutagenesis, Site-Directed; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Binding; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Terpenes; Thapsigargin; Tyrosine | 1996 |
Synergistic induction of neurite outgrowth by nerve growth factor or epidermal growth factor and interleukin-6 in PC12 cells.
Topics: Animals; Carrier Proteins; Drug Synergism; Epidermal Growth Factor; GAP-43 Protein; Interleukin-6; Membrane Glycoproteins; Membrane Proteins; Microtubule Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; PC12 Cells; Phosphorylation; Protein Binding; Rats; RNA, Messenger; Tyrosine | 1996 |
Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected].
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Integrins; MAP Kinase Kinase Kinase 1; Mice; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Tyrosine | 1996 |
An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line.
Topics: Calcium; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphorylation; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; T-Lymphocytes; Tyrosine | 1996 |
Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Insulin; Membrane Proteins; Phosphorylation; Protein Binding; Proteins; ras Proteins; Receptor, Insulin; Shc Signaling Adaptor Proteins; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1996 |
Bradykinin induces tyrosine phosphorylation in human foreskin fibroblasts and 293 cells transfected with rat B2 kinin receptor.
Topics: Animals; Bradykinin; Cell Line; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Insulin-Like Growth Factor I; Kidney; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Receptor, Bradykinin B2; Receptors, Bradykinin; Recombinant Proteins; Skin; Transfection; Tyrosine | 1996 |
Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Catenins; Cell Adhesion Molecules; Crk-Associated Substrate Protein; Delta Catenin; Epidermal Growth Factor; GRB2 Adaptor Protein; Oncogene Protein v-crk; Oncogene Proteins; PC12 Cells; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteins; Rats; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 1996 |
An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells.
Topics: Base Sequence; Cell Division; Cell Line; DNA Primers; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Hematopoietic Stem Cells; Janus Kinase 2; Milk Proteins; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1996 |
Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplifi
Topics: Androstadienes; Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Blotting, Western; Breast Neoplasms; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Glycoproteins; Humans; Insulin-Like Growth Factor I; Mitogens; Neuregulins; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1996 |
Steric constraints in the recognition of peptide substrates for the epidermal growth factor receptor kinase.
Topics: Binding Sites; Cysteine; Epidermal Growth Factor; ErbB Receptors; Fluoresceins; Fluorescent Dyes; Iodoacetamide; Kinetics; Mass Spectrometry; Molecular Weight; Oligopeptides; Phosphorylation; Protein Conformation; Signal Transduction; Substrate Specificity; Tyrosine | 1996 |
Ligand activation of overexpressed epidermal growth factor receptor results in loss of epithelial phenotype and impaired RGD-sensitive integrin function in HSC-1 cells.
Topics: Down-Regulation; Epidermal Growth Factor; Epithelium; ErbB Receptors; Humans; Integrin beta1; Integrins; Ligands; Oligopeptides; Phenotype; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 1996 |
Insulin potentiates mitogenic effect of epidermal growth factor on cultured guinea pig gastric mucous cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; Gastric Mucosa; Guinea Pigs; Insulin; Intracellular Membranes; Male; Mitogens; Osmolar Concentration; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Tyrosine phosphorylation of extracellular signal-regulated protein kinase 4 in response to growth factors.
Topics: Animals; Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Growth Substances; Immunoblotting; Kinetics; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factors; PC12 Cells; Phosphorylation; Precipitin Tests; ras Proteins; Rats; Signal Transduction; Tyrosine | 1996 |
The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro.
Topics: Animals; Bronchoalveolar Lavage Fluid; Catechols; Cell Line; Culture Media; Epidermal Growth Factor; ErbB Receptors; Hyperoxia; Lung; Nitriles; Phosphorylation; Rats; Reference Values; Suramin; Tyrosine; Tyrphostins | 1996 |
Detection of EGF-induced EGF receptor degradation and tyrosine phosphorylation in intact cells.
Topics: Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Liver; Phosphorylation; Phosphotyrosine; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Time Factors; Tyrosine | 1996 |
N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Brain; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Survival; COS Cells; DNA, Complementary; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Mice; Molecular Sequence Data; Neurons; Phosphorylation; Proteins; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Nerve Growth Factor; Sensitivity and Specificity; Sequence Homology, Amino Acid; Signal Transduction; src Homology Domains; Tyrosine | 1996 |
Effects of mitogens on androgen receptor-mediated transactivation.
Topics: Animals; Cell Line; COS Cells; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; HeLa Cells; Insulin-Like Growth Factor I; Intracellular Membranes; Isoflavones; Ligands; Mitogens; Phosphorylation; Phosphotyrosine; Rats; Receptors, Androgen; Signal Transduction; Transcriptional Activation; Tyrosine; Vanadates | 1996 |
A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Densitometry; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Immunoblotting; Liver; Mitogens; Phosphorylation; Pregnancy; Proteins; Rats; Rats, Sprague-Dawley; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Thymidine; Time Factors; Transforming Growth Factor alpha; Tyrosine | 1996 |
A comparative study of the hepatic mitogen-activated protein kinase and Jun-NH2-terminal kinase pathways in the late-gestation fetal rat.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Female; Gestational Age; GRB2 Adaptor Protein; Hepatocyte Growth Factor; JNK Mitogen-Activated Protein Kinases; Liver; Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Tyrosine | 1996 |
Epidermal growth factor-regulated signal transduction in hormone dependent and independent breast cancer.
Topics: Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphorylation; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1996 |
C-Met signalling in an HGF/SF-insensitive variant MDCK cell line with constitutive motile/invasive behaviour.
Topics: Animals; Benzoquinones; Cell Line; Cell Movement; Cell Size; Dogs; Drug Resistance; Enzyme Inhibitors; Epidermal Growth Factor; Hepatocyte Growth Factor; Lactams, Macrocyclic; Phenotype; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Signal Transduction; Tyrosine | 1996 |
Cholecystokinin stimulates formation of shc-grb2 complex in rat pancreatic acinar cells through a protein kinase C-dependent mechanism.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cholecystokinin; Epidermal Growth Factor; GRB2 Adaptor Protein; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Mice; Pancreas; Phosphorylation; Protein Kinase C; Proteins; ras Guanine Nucleotide Exchange Factors; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Tyrosine | 1996 |
Luteinizing hormone-releasing hormone agonists interfere with the stimulatory actions of epidermal growth factor in human prostatic cancer cell lines, LNCaP and DU 145.
Topics: Cell Division; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Gonadotropin-Releasing Hormone; Humans; Male; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine | 1996 |
Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor.
Topics: Adenylyl Cyclases; Bradykinin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Humans; Isoproterenol; Oncogene Proteins; Phosphorylation; Serine; Threonine; Tumor Cells, Cultured; Tyrosine | 1996 |
Peroxovanadate induces tyrosine phosphorylation of multiple signaling proteins in mouse liver and kidney.
Topics: Animals; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Injections, Intraperitoneal; Kidney; Liver; Mice; Molecular Weight; Phosphorylation; Protein Sorting Signals; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; STAT1 Transcription Factor; Trans-Activators; Tyrosine; Vanadates | 1997 |
Functional characterization of an epidermal growth factor receptor/RET chimera.
Topics: 3T3 Cells; Animals; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mitogens; Oncogene Proteins; Phosphorylation; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tyrosine | 1997 |
Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Epithelium; Female; GPI-Linked Proteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Mammary Glands, Animal; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase 1; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; src Homology Domains; Tumor Cells, Cultured; Tyrosine | 1997 |
Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Humans; Isoproterenol; Phosphorylation; Receptors, Purinergic P1; Thymidine; Tyrosine; Vasodilator Agents | 1997 |
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Cloning, Molecular; DNA, Complementary; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, fos; GRB2 Adaptor Protein; Humans; Mice; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; Proteins; RNA Splicing; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1997 |
Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder.
Topics: Bacterial Proteins; Blotting, Northern; Blotting, Western; Cells, Cultured; Child; Child, Preschool; Chromatography, Affinity; Chromatography, High Pressure Liquid; Clone Cells; Diphtheria Toxin; DNA Probes; Epidermal Growth Factor; ErbB Receptors; Heparin; Humans; Immunohistochemistry; In Situ Hybridization; Muscle, Smooth; Phorbol Esters; Phosphorylation; RNA; Tyrosine; Urinary Bladder; Urinary Bladder Diseases; Urothelium | 1997 |
Structural aspects of the epidermal growth factor receptor required for transmodulation of erbB-2/neu.
Topics: Animals; Breast; Down-Regulation; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Flow Cytometry; Humans; Lysosomes; Mammary Glands, Animal; Mice; Phosphorylation; Rabbits; Receptor, ErbB-2; Tumor Cells, Cultured; Tyrosine | 1997 |
Human serotonin transporter: regulation by the neuroprotective agent aurintricarboxylic acid and by epidermal growth factor.
Topics: Aurintricarboxylic Acid; Biological Transport; Blotting, Northern; Carrier Proteins; Choriocarcinoma; Epidermal Growth Factor; Gene Expression; Genistein; Growth Inhibitors; Humans; Isoflavones; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuroprotective Agents; Phosphorylation; Placenta; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Tumor Cells, Cultured; Tyrosine | 1997 |
Cyclic changes in the organization of cell adhesions and the associated cytoskeleton, induced by stimulation of tyrosine phosphorylation in bovine aortic endothelial cells.
Topics: Animals; Aorta; Cattle; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Epidermal Growth Factor; Fluorescent Antibody Technique, Indirect; Intercellular Junctions; Microscopy, Fluorescence; Phosphorylation; Tyrosine; Vanadates | 1997 |
Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line.
Topics: Animals; Antibodies; Cell Count; Cell Division; Cell Line; Colon; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Growth Inhibitors; Growth Substances; Intercellular Junctions; Mice; Osmolar Concentration; Phosphorylation; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; DNA, Complementary; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, myc; Humans; Mice; Mitogens; Mutagenesis, Site-Directed; Phosphorylation; Proteins; ras Proteins; Signal Transduction; Tyrosine | 1997 |
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.
Topics: 3T3 Cells; Androstadienes; Animals; Cell Division; Chemotaxis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Ligands; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, ErbB-4; Transfection; Tyrosine; Wortmannin | 1997 |
Interaction of the adaptor protein Shc and the adhesion molecule cadherin.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cadherins; Cell Adhesion; Cell Size; Enzyme Inhibitors; Epidermal Growth Factor; Genetic Techniques; Mice; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatases; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine; Vanadates | 1997 |
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.
Topics: Amino Acid Sequence; Animals; Brain; Cell Adhesion; Dimerization; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Humans; Ligands; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Myocardium; Nerve Growth Factors; Neuregulins; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-3; Receptor, ErbB-4; Recombinant Proteins; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Tyrosine | 1997 |
A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis.
Topics: Animals; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Erythropoiesis; Erythropoietin; Gene Expression Regulation; Hemoglobins; Histocytochemistry; Immunoblotting; Janus Kinase 2; Mice; Milk Proteins; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Receptors, Prolactin; Recombinant Fusion Proteins; Signal Transduction; Spleen; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 1997 |
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Transformation, Neoplastic; Conserved Sequence; Epidermal Growth Factor; ErbB Receptors; Helminth Proteins; Mice; Mutation; Oncogene Protein v-cbl; Phosphorylation; Proline; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Rabbits; Retroviridae Proteins, Oncogenic; Tyrosine; Ubiquitin-Protein Ligases | 1997 |
Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes.
Topics: Animals; Antibodies; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; GTP-Binding Proteins; In Vitro Techniques; Isoenzymes; Membranes; Pancreas; Pertussis Toxin; Phosphorylation; Rats; Type C Phospholipases; Tyrosine; Virulence Factors, Bordetella | 1997 |
Detection of ERK activation by a novel monoclonal antibody.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites, Antibody; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; COS Cells; Drosophila melanogaster; Enzyme Activation; Epidermal Growth Factor; Eukaryota; HeLa Cells; Humans; Kinetics; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Phosphorylation; Point Mutation; Rats; Recombinant Proteins; Saccharomyces cerevisiae; Signal Transduction; Spodoptera; Threonine; Transfection; Tyrosine | 1997 |
Tyrosine phosphorylation-and epidermal growth factor-dependent regulation of the sodium-coupled amino acid transporter B0 in the human placental choriocarcinoma cell line JAR.
Topics: Alanine; Amino Acid Transport Systems; Amino Acid Transport Systems, Basic; Amino Acid Transport Systems, Neutral; Aurintricarboxylic Acid; Biological Transport; Carrier Proteins; Choriocarcinoma; Cloning, Molecular; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; HeLa Cells; Humans; Isoflavones; Leucine; Phosphorylation; Placenta; Tumor Cells, Cultured; Tyrosine; Uterine Neoplasms | 1997 |
Mitosis-specific negative regulation of epidermal growth factor receptor, triggered by a decrease in ligand binding and dimerization, can be overcome by overexpression of receptor.
Topics: 3T3 Cells; Animals; Dimerization; Epidermal Growth Factor; ErbB Receptors; G1 Phase; Gene Expression; Humans; Ligands; Mice; Mitosis; Phosphorylation; Rats; Resting Phase, Cell Cycle; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1997 |
The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Genes, Tumor Suppressor; Linoleic Acids; Lipid Peroxides; Mesocricetus; Phenotype; Phosphorylation; Signal Transduction; Tyrosine | 1997 |
Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cells. Ide
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Kidney; Membrane Proteins; Mutagenesis; Nerve Growth Factors; Neurites; PC12 Cells; Protein Kinases; Proteins; Rats; Shc Signaling Adaptor Proteins; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 1997 |
TGF-beta isoforms differentially attenuate EGF mitogenicity and receptor activity in fetal lung mesenchymal cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Fetus; Isomerism; Lung; Mesoderm; Mice; Mitogens; Phosphorylation; Phosphotransferases; Signal Transduction; Substrate Specificity; Thymidine; Transforming Growth Factor beta; Tyrosine | 1997 |
A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Arsenicals; Binding Sites; Cell Line; Cricetinae; Cricetulus; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Immunosorbent Techniques; Isoenzymes; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Rats; Recombinant Fusion Proteins; Sulfhydryl Compounds; Type C Phospholipases; Tyrosine | 1997 |
Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells.
Topics: Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Transcription Factors; Tyrosine | 1997 |
[Dynamics of EGF-induced nuclear-cytoplasmic transport of transcription factor STAT1 in A431 cells].
Topics: Acetates; Binding Sites; Biological Transport; Blotting, Western; Buffers; Carcinoma, Squamous Cell; Cell Nucleus; Cytoplasm; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Phosphorylation; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 1997 |
Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth.
Topics: Actins; Animals; Cell Adhesion; Cell Division; Cell Survival; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Ligands; Male; Metalloendopeptidases; Muscle, Smooth, Vascular; Phosphorylation; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor Aggregation; Receptors, Vitronectin; Tenascin; Tyrosine | 1997 |
Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton.
Topics: Actins; Animals; Cells, Cultured; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeleton; DNA Replication; Epidermal Growth Factor; GTPase-Activating Proteins; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Proteins; Rats; Retinoblastoma-Like Protein p130; Tyrosine | 1997 |
Epidermal growth factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2, a SH2 domain-containing protein tyrosine phosphatase.
Topics: Animals; Antigens, Differentiation; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Neural Cell Adhesion Molecule L1; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Rats; Receptors, Immunologic; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine | 1997 |
Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex.
Topics: Animals; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Initiation Factor-2; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; Insulin; Macromolecular Substances; Phosphorylation; Protein Conformation; Protein Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; rap GTP-Binding Proteins; ras Guanine Nucleotide Exchange Factors; src Homology Domains; Tyrosine | 1997 |
Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Clone Cells; Enkephalin, Leucine-2-Alanine; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gene Expression; Isomerism; Mice; Mitogen-Activated Protein Kinase 1; Pertussis Toxin; Phosphorylation; Proteins; Rats; Receptors, Opioid, delta; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Time Factors; Transfection; Tyrosine; Virulence Factors, Bordetella | 1997 |
Reduced ability of transforming growth factor-alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB2.
Topics: Antibodies; Antibody Specificity; Carcinoma, Squamous Cell; Dimerization; Down-Regulation; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; Ligands; Phosphorylation; Precipitin Tests; Receptor, ErbB-2; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1997 |
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium-Binding Proteins; Carrier Proteins; Cell Line; Cloning, Molecular; COS Cells; DNA, Complementary; Epidermal Growth Factor; Fungal Proteins; GTPase-Activating Proteins; Mice; Molecular Sequence Data; Phosphorylation; src Homology Domains; Tyrosine | 1997 |
Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Line, Transformed; Culture Media, Serum-Free; Cyclin-Dependent Kinases; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Humans; Lymphoma, B-Cell; Mice; Oncogene Protein v-cbl; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Retroviridae Proteins, Oncogenic; Tumor Cells, Cultured; Tyrosine; Ubiquitin-Protein Ligases | 1997 |
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Humans; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Binding; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1997 |
Epiregulin stimulates proliferation of rabbit gastric cells in primary culture through autophosphorylation of the epidermal growth factor receptor.
Topics: Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gastric Mucosa; Genistein; Phosphorylation; Protein-Tyrosine Kinases; Rabbits; Tyrosine | 1997 |
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; COS Cells; Cytoplasm; Endoplasmic Reticulum; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Substrate Specificity; Tyrosine | 1998 |
Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity.
Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Intestinal Mucosa; Mice; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1998 |
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Topics: Androstadienes; Cell Movement; Chromones; Cytoplasm; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; ras Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1998 |
MS-430, a synthetic pyrimidine derivative, influences the intracellular signal transduction pathway leading to neuronal differentiation of PC12h cells.
Topics: Acetylcholinesterase; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Epidermal Growth Factor; ErbB Receptors; Male; Mice; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phosphorylation; Proto-Oncogene Proteins; Pyrimidines; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Tyrosine | 1998 |
The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin.
Topics: Animals; Antibodies, Monoclonal; Betacellulin; Binding Sites; Breast Neoplasms; Cell Differentiation; Cell Division; Dimerization; Epidermal Growth Factor; ErbB Receptors; Female; Growth Substances; Hematopoietic Stem Cells; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Mice; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine | 1998 |
Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; CHO Cells; Cricetinae; Dimerization; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Ligands; Phosphorylation; Signal Transduction; Tyrosine | 1998 |
Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development.
Topics: Embryonic and Fetal Development; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genistein; Homeostasis; Humans; Lung; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tyrosine; Tyrphostins | 1998 |
EGF-dependent and independent programmed cell death pathways in NCI-H596 nonsmall cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non-Small-Cell Lung; Cell Division; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1998 |
Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Differentiation; Cell Transformation, Neoplastic; COS Cells; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Initiation Factor-2; Guanine Nucleotide Exchange Factors; Humans; Mice; Mutation; Neurons; PC12 Cells; Phosphorylation; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-crk; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Transforming Growth Factor beta; Tyrosine; Ubiquitin-Protein Ligases | 1998 |
Regulation of IL-6 signaling by p53: STAT3- and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines.
Topics: Amino Acid Substitution; Carcinoma, Hepatocellular; Cytokines; DNA-Binding Proteins; Dose-Response Relationship, Immunologic; Epidermal Growth Factor; Humans; Interferon-gamma; Interleukin-6; Milk Proteins; Mutation; Phenotype; Phosphatidylinositol Diacylglycerol-Lyase; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Temperature; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Type C Phospholipases; Tyrosine; Valine | 1998 |
Absence of autophosphorylation site Y882 in the p185neu oncogene product correlates with a reduction of transforming potential.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cell Division; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Mitogens; Mutagenesis, Site-Directed; Oncogenes; Phenylalanine; Phosphorylation; Rats; Receptor, ErbB-2; Tyrosine | 1998 |
Influence of tyrosine and phenylalanine limitation of cytotoxicity of chimeric TGF-alpha toxins on B16BL6 murine melanoma in vitro.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Cell Membrane; Culture Media; Epidermal Growth Factor; Heparin; Melanoma; Mice; Phenylalanine; Proteoglycans; Recombinant Fusion Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1998 |
Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-Bbeta.
Topics: 3T3 Cells; Animals; Epidermal Growth Factor; Humans; Mice; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Receptors, Platelet-Derived Growth Factor; Signal Transduction; src Homology Domains; Tyrosine | 1998 |
Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; GRB2 Adaptor Protein; Guanine Nucleotide Exchange Factors; Mutation; Nerve Growth Factors; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Guanine Nucleotide Exchange Factors; ras Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1998 |
Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Proteins; Ionomycin; Models, Biological; Nitriles; PC12 Cells; Phorbol Esters; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Quinazolines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins; Ubiquitin-Protein Ligases; Uridine Triphosphate | 1998 |
The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Differentiation; Clone Cells; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Fungal Proteins; Gene Expression Regulation, Neoplastic; Isoenzymes; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; PC12 Cells; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Proteins; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Schizosaccharomyces pombe Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases; Tyrosine | 1998 |
In vivo and in vitro assessment of mitogen activated protein kinase involvement during quail secondary palate formation.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Embryo, Nonmammalian; Epidermal Growth Factor; Mesoderm; Morphogenesis; Myelin Basic Protein; Palate; Phosphotransferases; Quail; Tyrosine | 1998 |
The epidermal growth factor receptor tyrosine kinase phosphorylates connexin32.
Topics: Animals; Blotting, Western; Calmodulin; Calpain; Cell Membrane; Chromatography, Affinity; Connexins; Epidermal Growth Factor; ErbB Receptors; Gap Junction beta-1 Protein; Gap Junctions; Kinetics; Liver; Male; Mice; Phosphoamino Acids; Phosphorylation; Rats; Rats, Sprague-Dawley; Tyrosine | 1998 |
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression Regulation; Guanosine Triphosphate; Molecular Sequence Data; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Consensus Sequence; Epidermal Growth Factor; Genistein; Insulin; Membrane Potentials; Mutagenesis, Site-Directed; Nerve Growth Factors; Oocytes; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Tyrosine; Vanadates; Xenopus laevis | 1998 |
Conjugate chemistry, iodination and cellular binding of mEGF-dextran-tyrosine: preclinical tests in preparation for clinical trials.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Dextrans; Epidermal Growth Factor; ErbB Receptors; Glioma; Iodine Radioisotopes; Mice; Tumor Cells, Cultured; Tyrosine | 1998 |
Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Epidermal Growth Factor; Epithelial Cells; Gastric Mucosa; Gastrins; Guinea Pigs; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Male; Parietal Cells, Gastric; Phosphorylation; Precipitin Tests; Rats; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; RNA, Messenger; Transfection; Tyrosine | 1999 |
The expression of transforming growth factor alpha receptor protein and its activation in chicken ovarian granulosa cells of maturing follicles.
Topics: Animals; Chickens; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Granulosa Cells; Humans; Luteinizing Hormone; Ovary; Phosphorylation; Tyrosine | 1998 |
Role of epidermal growth factor and its receptor in mechanical stress-induced differentiation of human periodontal ligament cells in vitro.
Topics: Actins; Alkaline Phosphatase; Bite Force; Blotting, Western; Cell Differentiation; Cell Division; Cells, Cultured; Dental Cementum; Dexamethasone; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fluorescent Dyes; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glucocorticoids; Humans; Osteoblasts; Osteocalcin; Periodontal Ligament; Phalloidine; Phosphorylation; Rhodamines; RNA, Messenger; Stem Cells; Stress, Mechanical; Tyrosine; Up-Regulation | 1998 |
EGF-stimulated aldosterone secretion is mediated by tyrosine phosphorylation but not by phospholipase C in cultured porcine adrenal glomerulosa cells.
Topics: Aldosterone; Angiotensin II; Animals; Cells, Cultured; Epidermal Growth Factor; Inositol Phosphates; Phosphorylation; Signal Transduction; Stimulation, Chemical; Swine; Type C Phospholipases; Tyrosine; Zona Glomerulosa | 1998 |
Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; GRB2 Adaptor Protein; Humans; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Skin; src Homology Domains; Tyrosine | 1999 |
Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell-Free System; Chorionic Gonadotropin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Ovary; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Receptors, LH; Time Factors; Tyrosine; Virulence Factors, Bordetella | 1999 |
The functional role of CrkII in actin cytoskeleton organization and mitogenesis.
Topics: Actins; Cells, Cultured; Cytoskeleton; DNA Replication; Electroporation; Epidermal Growth Factor; Humans; Insulin; Insulin-Like Growth Factor I; Microinjections; Mitosis; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-crk; Receptor, Insulin; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Tyrosine; Ubiquitin-Protein Ligases | 1999 |
Activation of epidermal growth factor receptor in the early phase after renal ischemia-reperfusion in rat.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Epidermal Growth Factor; ErbB Receptors; Kidney; Male; Mitochondria; Oxygen; Phosphorylation; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 1999 |
EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells.
Topics: Animals; Cell Line; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; HeLa Cells; Humans; Interferons; Intestinal Mucosa; Phosphorylation; STAT1 Transcription Factor; STAT2 Transcription Factor; Tissue Distribution; Trans-Activators; Tyrosine | 1999 |
EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Trachea; Tyrosine | 1999 |
p42-MAP kinase is activated in EGF-stimulated interphase but not in metaphase-arrested HeLa cells.
Topics: Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Interphase; Metaphase; Mitogen-Activated Protein Kinase 1; Phosphorylation; Tyrosine | 1999 |
EGF stimulates tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on phosphatidylinositol 3-kinase, the small GTP-binding protein, p21rho, and the integrit
Topics: Actins; Animals; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; In Vitro Techniques; Kinetics; Male; Pancreas; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Type C Phospholipases; Tyrosine | 1999 |
EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1.
Topics: Binding Sites; Calcium; Epidermal Growth Factor; Fibrillin-1; Fibrillins; Humans; Magnetic Resonance Spectroscopy; Marfan Syndrome; Microfilament Proteins; Mutation; Phenotype; Protein Binding; Protein Structure, Secondary; Spectrometry, Fluorescence; Tyrosine | 1999 |
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Topics: Animals; Cell Membrane; COS Cells; Epidermal Growth Factor; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Possible regulation of epidermal growth factor-receptor tyrosine autophosphorylation by calcium and G proteins in chemically permeabilized rat UMR106 cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Carcinoma; Cell Membrane Permeability; Culture Media; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; GTP-Binding Proteins; Humans; Osteoblasts; Osteosarcoma; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrosine; Vanadates | 1999 |
Coupling difficulty following replacement of Tyr with HOTic during synthesis of an analog of an EGF B-loop fragment.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Humans; Mass Spectrometry; Peptide Biosynthesis; Time Factors; Tyrosine | 1999 |
Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinase-dependent pathway.
Topics: Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colon; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Keratins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Serine; Signal Transduction; Solubility; Tyrosine; Vanadates | 1999 |
Carbachol activates ERK2 in isolated gastric parietal cells via multiple signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Dogs; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Genes, Dominant; GRB2 Adaptor Protein; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Parietal Cells, Gastric; Phosphorylation; Proteins; ras Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Son of Sevenless Proteins; Transfection; Tyrosine | 1999 |
The release of acetylcholine receptor inducing activity (ARIA) from its transmembrane precursor in transfected fibroblasts.
Topics: Amino Acid Sequence; Animals; CHO Cells; COS Cells; Cricetinae; Epidermal Growth Factor; Fibroblasts; Immunohistochemistry; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Phosphorylation; Sequence Deletion; Transfection; Tyrosine | 1999 |
A tyrosine-based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration.
Topics: Amino Acid Sequence; Animals; CD18 Antigens; Cell Adhesion; Cell Membrane; Cell Movement; CHO Cells; Cricetinae; Cytoplasm; Endocytosis; Epidermal Growth Factor; Humans; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Signal Transduction; Tyrosine | 1999 |
Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding.
Topics: Animals; Base Sequence; CHO Cells; Cricetinae; Dimerization; DNA Primers; Epidermal Growth Factor; ErbB Receptors; Ligands; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Tyrosine | 1999 |
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7.
Topics: Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; ErbB Receptors; Leupeptins; Ligands; Ligases; Models, Biological; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Recombinant Fusion Proteins; Two-Hybrid System Techniques; Tyrosine; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins; Zinc Fingers | 1999 |
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Apoptosis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epidermal Growth Factor; Gene Targeting; Herbicides; Heterozygote; Homozygote; Hydrogen Peroxide; Longevity; Male; Mice; Oxidative Stress; Paraquat; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Selection, Genetic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Suppressor Protein p53; Tyrosine; Ultraviolet Rays; Up-Regulation | 1999 |
The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor.
Topics: Amino Acid Sequence; Biological Transport; Conserved Sequence; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Hemagglutinins; Intracellular Membranes; Luminescent Proteins; Mutation; Peptide Fragments; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Recombinant Fusion Proteins; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitins | 2000 |
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
Topics: Caenorhabditis elegans Proteins; Cell-Free System; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Helminth Proteins; Ligases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Tyrosine; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases | 1999 |
Protein kinase C is involved in enhanced airway smooth muscle cell growth in hyperresponsive rats.
Topics: Animals; Bronchi; Bronchial Hyperreactivity; Cattle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Fluid flow-induced tyrosine phosphorylation and participation of growth factor signaling pathway in osteoblast-like cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Cell Line; Culture Media; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Gene Expression Regulation; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Quinazolines; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stress, Mechanical; Transcription Factors; Tyrosine; Tyrphostins | 2000 |
Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Carrier Proteins; Cells, Cultured; Cloning, Molecular; COS Cells; DNA, Complementary; Epidermal Growth Factor; Humans; Molecular Sequence Data; Phosphorylation; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; src Homology Domains; Tissue Distribution; Tumor Cells, Cultured; Tyrosine; Ubiquitin-Protein Ligases | 2000 |
Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Binding Sites; Blotting, Western; Cell Nucleus; CHO Cells; Cricetinae; Cytoplasm; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Intracellular Fluid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Phosphoric Monoester Hydrolases; Phosphorylation; Signal Transduction; Threonine; Transfection; Tyrosine | 2000 |
ErbB-4 activation promotes neurite outgrowth in PC12 cells.
Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ligands; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neuregulin-1; Neurites; PC12 Cells; Phosphorylation; Protein Kinase C; Rats; Receptor, ErbB-4; Tyrosine | 2000 |
Epidermal growth factor stimulates phospholipase cgamma1 in cultured rabbit corneal epithelial cells.
Topics: Animals; Epidermal Growth Factor; Epithelial Cells; Epithelium, Corneal; ErbB Receptors; Hydrolysis; Isoenzymes; Phospholipase C gamma; Phosphorylation; Rabbits; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Type C Phospholipases; Tyrosine; Tyrphostins | 2000 |
Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status.
Topics: Animals; Caveolin 1; Caveolins; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Isoforms; Pyrazoles; Pyrimidines; Recombinant Proteins; Signal Transduction; src-Family Kinases; Tyrosine | 2000 |
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.
Topics: Animals; Binding Sites; Cell Division; Cell Line; Dogs; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Isoenzymes; Microtubules; Mutation; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-met; Signal Transduction; Type C Phospholipases; Tyrosine | 2000 |
Oncostatin M suppresses EGF-mediated protein tyrosine phosphorylation in breast cancer cells.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Culture Media; Cytokines; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Inflammation Mediators; Oncostatin M; Peptides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Time Factors; Tumor Cells, Cultured; Tyrosine | 2000 |
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.
Topics: Androstadienes; Blotting, Southern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dimerization; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Esophageal Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Ligands; Morpholines; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
Vav family proteins couple to diverse cell surface receptors.
Topics: Amino Acid Sequence; Animals; Cell Cycle Proteins; Cell Line; CHO Cells; COS Cells; Cricetinae; DNA, Complementary; Epidermal Growth Factor; Guanine Nucleotide Exchange Factors; Humans; Integrins; Jurkat Cells; Mice; Molecular Sequence Data; Oncogene Proteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, Cell Surface; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2000 |
Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Line; Cytokines; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; Genes, myc; Growth Substances; HeLa Cells; Humans; Interleukin-3; Molecular Sequence Data; Phosphoproteins; Phosphotyrosine; Promoter Regions, Genetic; Protein Isoforms; Receptors, Cytokine; Receptors, Growth Factor; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2000 |
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Ovarian Neoplasms; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proteins; Quinazolines; Receptor, Endothelin A; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
Suppression of epidermal growth factor-induced phospholipase C activation associated with actin rearrangement in rat hepatocytes in primary culture.
Topics: Actins; Animals; Biological Transport; Calcium; Cells, Cultured; Cytoskeleton; Enzyme Activation; Enzyme Induction; Epidermal Growth Factor; ErbB Receptors; Hepatocytes; Isoenzymes; Male; Phospholipase C gamma; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors; Type C Phospholipases; Tyrosine | 2000 |
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Caveolae; Caveolin 1; Caveolins; Cell Adhesion; Cell Division; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; GRB7 Adaptor Protein; Growth Substances; Humans; Insulin; Lipid Metabolism; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phosphorylation; Proteins; Signal Transduction; src-Family Kinases; Tyrosine; Vanadates | 2000 |
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; E-Selectin; Epidermal Growth Factor; Humans; Lectins; Leukocytes; Membrane Glycoproteins; Models, Molecular; Molecular Sequence Data; Oligosaccharides; P-Selectin; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Static Electricity; Structure-Activity Relationship; Sulfur; Tyrosine | 2000 |
Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation.
Topics: Breast; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Humans; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Signal Transduction; Transfection; Tyrosine | 2000 |
Involvement of insulin receptor substrates in epidermal growth factor induced activation of phosphatidylinositol 3-kinase in rat hepatocyte primary culture.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Hepatocytes; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Receptor, Insulin; Time Factors; Tyrosine | 2001 |
Kinase suppressor of Ras signals through Thr269 of c-Raf-1.
Topics: Animals; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Humans; Mice; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Proteins; Serine; Signal Transduction; Threonine; Transfection; Tyrosine; Valine | 2001 |
Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.
Topics: Adenoviridae; Animals; Arabidopsis Proteins; Blotting, Western; Cell Line; CHO Cells; Cricetinae; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Ligands; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plant Proteins; Potassium Channels; Precipitin Tests; Protein Isoforms; Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 2001 |
Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability.
Topics: Animals; Antibodies, Monoclonal; Cell Membrane; Cells, Cultured; Dogs; Electric Impedance; Epidermal Growth Factor; ErbB Receptors; Gap Junctions; Gastric Mucosa; Intracellular Membranes; Permeability; Phosphorylation; Tyrosine | 2001 |
Epidermal growth factor receptor mediates stress-induced expression of its ligands in rat gastric epithelial cells.
Topics: Amphiregulin; Animals; Blotting, Western; Culture Media, Serum-Free; DNA, Complementary; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gastric Mucosa; Gene Expression Regulation; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Oxidative Stress; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-met; Rats; Rats, Wistar; Receptor, ErbB-2; Receptor, ErbB-3; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tyrosine | 2001 |
Localization of phospholipase C-gamma1 signaling in caveolae: importance in EGF-induced phosphoinositide hydrolysis but not in tyrosine phosphorylation.
Topics: Animals; beta-Cyclodextrins; Blotting, Western; Caveolae; Caveolin 1; Caveolins; Cell Compartmentation; Cell Line; Cell Membrane; COS Cells; Cyclodextrins; Epidermal Growth Factor; Hydrolysis; Isoenzymes; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Signal Transduction; Type C Phospholipases; Tyrosine | 2001 |
Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF.
Topics: Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Interleukin-3; Kinetics; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Signal Transduction; Transcription Factors; Tyrosine | 2001 |
Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes.
Topics: Antigens, Differentiation; Cell Differentiation; Cell Division; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Keratinocytes; Phosphorylation; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; Tyrosine | 2001 |
Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts.
Topics: Actins; Animals; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; Glutathione Transferase; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Mice; Mice, Inbred C3H; Microinjections; Nuclear Proteins; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Repressor Proteins; Tyrosine | 2001 |
Detection of tyrosine phosphorylated peptides by precursor ion scanning quadrupole TOF mass spectrometry in positive ion mode.
Topics: Amino Acid Sequence; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mass Spectrometry; Molecular Sequence Data; Peptides; Phosphorylation; Phosphotyrosine; Sensitivity and Specificity; Signal Transduction; Tyrosine | 2001 |
Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras.
Topics: 3T3 Cells; Amino Acid Motifs; Animals; Blotting, Western; Cell Division; Cell Line; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Erythropoietin; Humans; Interleukin-2; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutation; p120 GTPase Activating Protein; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; ras Proteins; Repressor Proteins; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thymidine; Trans-Activators; Transcription Factors; Transfection; Tyrosine | 2001 |
Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor.
Topics: Animals; Apoptosis; Blotting, Northern; Blotting, Western; Calcium; Cell Survival; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Connexins; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Hydrogen Peroxide; Immediate-Early Proteins; Liver; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Transcription Factors; Tyrosine | 2001 |
The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Chromatography, Affinity; Cloning, Molecular; COS Cells; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gene Deletion; Genetic Vectors; Histidine; Microscopy, Confocal; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositol Phosphates; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Shc Signaling Adaptor Proteins; Transfection; Tyrosine | 2001 |
Activation of human airway epithelial cells by non-HLA antibodies developed after lung transplantation: a potential etiological factor for bronchiolitis obliterans syndrome.
Topics: Antibodies; Bronchiolitis Obliterans; Cell Division; Cell Line; Epidermal Growth Factor; Epithelial Cells; Heparin-binding EGF-like Growth Factor; HLA Antigens; Humans; Intercellular Signaling Peptides and Proteins; Lung; Lung Transplantation; Phosphorylation; Postoperative Period; Transforming Growth Factor beta; Tyrosine; Up-Regulation | 2001 |
Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF.
Topics: Adaptor Proteins, Signal Transducing; Antigens, CD; Antimalarials; Cell Compartmentation; Chloroquine; Endosomes; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Intramolecular Transferases; Lysosomal Membrane Proteins; Lysosomes; Membrane Glycoproteins; Membrane Proteins; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Membrane Glycoproteins; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Tetraspanin 30; Tyrosine; Ubiquitin-Protein Ligases; Vesicular Transport Proteins | 2001 |
Expression and tyrosine phosphorylation of E-cadherin, beta- and gamma-catenin, and epidermal growth factor receptor in cervical cancer cells.
Topics: beta Catenin; Blotting, Western; Cadherins; Cell Adhesion; Cytoskeletal Proteins; Desmoplakins; Epidermal Growth Factor; ErbB Receptors; Female; gamma Catenin; Humans; Phosphorylation; Precipitin Tests; Trans-Activators; Tumor Cells, Cultured; Tyrosine; Uterine Cervical Neoplasms | 2001 |
Upregulation of phospholipase Cgamma1 activity during EGF-induced proliferation of corneal epithelial cells: effect of phosphoinositide-3 kinase.
Topics: Animals; Blotting, Western; Cell Division; Cell Line, Transformed; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; Inositol 1,4,5-Trisphosphate; Isoenzymes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Rabbits; Simian virus 40; Time Factors; Type C Phospholipases; Tyrosine; Up-Regulation | 2001 |
Identification of Src phosphorylation sites in the catenin p120ctn.
Topics: Animals; Binding Sites; Blotting, Western; Catenins; Cell Adhesion Molecules; Cell Line; COS Cells; Cytoplasm; Delta Catenin; DNA Mutational Analysis; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Gene Deletion; Genes, Dominant; Glutathione Transferase; Humans; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Transfection; Tyrosine; Vanadates | 2001 |
A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo.
Topics: 3T3 Cells; Animals; Base Sequence; COS Cells; Epidermal Growth Factor; ErbB Receptors; Fluorescence; Mice; Molecular Sequence Data; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Tyrosine | 2001 |
Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cloning, Molecular; Cricetinae; DNA, Complementary; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Mesocricetus; Mice; Mitogens; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Tyrosine | 2001 |
Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431 epidermoid carcinoma cells.
Topics: Carcinoma, Squamous Cell; Catalase; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Hydrogen Peroxide; Isoenzymes; Oxidants; Phospholipase D; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Tumor Cells, Cultured; Tyrosine | 2001 |
IRS-1 tyrosine phosphorylation reflects insulin-induced metabolic and mitogenic responses in 3T3-L1 pre-adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Blotting, Western; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Glycogen; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Recombinant Fusion Proteins; Thymidine; Time Factors; Tyrosine | 2001 |
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 2001 |
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.
Topics: Animals; Blotting, Northern; Cell Line; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Genes, Dominant; Humans; Intracellular Signaling Peptides and Proteins; Luciferases; Mitogen-Activated Protein Kinases; Mutation; Nerve Tissue Proteins; PC12 Cells; Plasmids; Protein Structure, Tertiary; Rats; Time Factors; Transfection; Tyrosine | 2001 |
Growth-inhibitory effect of a streptococcal antitumor glycoprotein on human epidermoid carcinoma A431 cells: involvement of dephosphorylation of epidermal growth factor receptor.
Topics: Antibiotics, Antineoplastic; Bacterial Proteins; Carcinoma, Squamous Cell; Catalase; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Growth Inhibitors; GTP-Binding Proteins; Humans; MAP Kinase Signaling System; Pertussis Toxin; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Tyrosine; Vanadates; Virulence Factors, Bordetella | 2001 |
Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor.
Topics: 3T3 Cells; Animals; Carrier Proteins; CHO Cells; Cricetinae; Dimerization; Epidermal Growth Factor; ErbB Receptors; Humans; Intercellular Signaling Peptides and Proteins; Introns; Kinetics; Mice; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Receptor, ErbB-2; Receptor, ErbB-3; Transcriptional Activation; Transfection; Tyrosine | 2001 |
Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling.
Topics: Angiotensin II; Animals; beta-Cyclodextrins; Caveolin 1; Caveolins; Cell Membrane; Cells, Cultured; Cholesterol; Cyclodextrins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Male; Microscopy, Electron; Muscle, Smooth, Vascular; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcriptional Activation; Tyrosine | 2001 |
Adhesion, actin cytoskeleton organisation and the spreading of colon adenocarcinoma cells induced by EGF are mediated by alpha2beta1 integrin low clustering through focal adhesion kinase.
Topics: Actins; Antibodies, Monoclonal; Calcium; Cell Adhesion; Cell Movement; Collagen Type IV; Cytoskeleton; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HT29 Cells; Humans; Immunoblotting; Integrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Collagen; Time Factors; Tyrosine | 2001 |
Novel activation of STAT5b in response to epidermal growth factor.
Topics: Amino Acid Sequence; Blotting, Western; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; Epitopes; ErbB Receptors; Genetic Vectors; Humans; Immunoblotting; Luciferases; Milk Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Phosphorylation; Precipitin Tests; Sequence Homology, Amino Acid; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Trypsin; Tumor Cells, Cultured; Tyrosine | 2002 |
Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor.
Topics: Blotting, Western; Carcinoma; Cell Division; Cytoskeletal Proteins; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Interleukin-1; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; Phenotype; Phosphoproteins; Phosphorylation; Translocation, Genetic; Tumor Cells, Cultured; Tyrosine | 2001 |
Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
Topics: Animals; Cell Line; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glomerular Mesangium; Glucose; Heparin-binding EGF-like Growth Factor; Hexokinase; Immunohistochemistry; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Ligands; MAP Kinase Signaling System; Mice; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells.
Topics: Aluminum; Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Collagen; Crk-Associated Substrate Protein; Epidermal Growth Factor; Fluorine; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Insulin; Lysophospholipids; Mice; Molecular Sequence Data; Osteoblasts; Pertussis Toxin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Pyrimidines; Pyrroles; Retinoblastoma-Like Protein p130; Signal Transduction; src-Family Kinases; Stem Cells; Tyrosine; Virulence Factors, Bordetella | 2002 |
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Topics: Adenocarcinoma; Animals; cdc42 GTP-Binding Protein; Cell Division; Chemotaxis; Epidermal Growth Factor; Epithelium; Lung Neoplasms; Mammary Neoplasms, Experimental; Multigene Family; Rats; rho GTP-Binding Proteins; Signal Transduction; Stress Fibers; Transfection; Tumor Cells, Cultured; Tyrosine | 2001 |
EGFR-independent activation of ERK1/2 mediates growth inhibition by a PTPase antagonizing K-vitamin analog.
Topics: cdc25 Phosphatases; Cell Division; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Growth Inhibitors; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-raf; Reference Values; Time Factors; Transfection; Tyrosine; Vitamin K | 2002 |
c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation.
Topics: Animals; Enzyme Activation; Epidermal Growth Factor; Fluorescent Antibody Technique; Genes, src; Kinetics; Mitogen-Activated Protein Kinases; Neurites; Neurons; PC12 Cells; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; Signal Transduction; src-Family Kinases; Tyrosine | 2002 |
Epidermal growth factor receptor and tyrosine phosphorylation of estrogen receptor.
Topics: Animals; Breast Neoplasms; Cell Death; Cell Division; COS Cells; Epidermal Growth Factor; ErbB Receptors; Estrogens; Female; Humans; Phosphorylation; Receptors, Estrogen; Response Elements; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2001 |
ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.
Topics: Adaptor Proteins, Signal Transducing; Blotting, Western; Butadienes; Cell Line; Culture Media, Serum-Free; Enzyme Inhibitors; Epidermal Growth Factor; Glutathione Transferase; Helminth Proteins; Humans; Mitogen-Activated Protein Kinases; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Tyrosine | 2002 |
Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Epidermal Growth Factor; GRB2 Adaptor Protein; Insulin; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proteins; Tyrosine | 2002 |
A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Agar; Anaplastic Lymphoma Kinase; Animals; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Glutathione Transferase; GRB2 Adaptor Protein; Isoenzymes; Ligands; MAP Kinase Signaling System; Mice; Phenotype; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine; Up-Regulation | 2002 |
Herstatin, an autoinhibitor of the human epidermal growth factor receptor 2 tyrosine kinase, modulates epidermal growth factor signaling pathways resulting in growth arrest.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; CHO Cells; Cricetinae; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Intercellular Signaling Peptides and Proteins; Mice; Phosphorylation; Proteins; Signal Transduction; Tyrosine | 2002 |
Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
Topics: Animals; Enzyme Activation; Epidermal Growth Factor; Isoenzymes; Male; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Tyrosine | 2002 |
Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B.
Topics: Animals; Carbohydrate Sequence; Cell Division; Dogs; Epidermal Growth Factor; ErbB Receptors; G(M1) Ganglioside; G(M3) Ganglioside; Gangliosides; Humans; Molecular Sequence Data; Neuroblastoma; Phosphorylation; Structure-Activity Relationship; Tumor Cells, Cultured; Tyrosine | 2002 |
Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice.
Topics: Androgens; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Apoptosis; Blood Vessels; Cell Cycle Proteins; Cell Division; Cetuximab; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Paclitaxel; Phosphorylation; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Up-Regulation; Xenograft Model Antitumor Assays | 2002 |
Indomethacin delays gastric restitution: association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers.
Topics: Actins; Animals; Apoptosis; Caspase 3; Caspases; Cell Death; Cell Line; Cell Movement; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastric Mucosa; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Indomethacin; Male; Microfilament Proteins; Mitomycin; Necrosis; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Stomach; Stress Fibers; Tensins; Time Factors; Tyrosine | 2002 |
EGF-dependent association of phospholipase C-gamma1 with c-Cbl.
Topics: 3T3 Cells; Animals; Becaplermin; Calcium; Cell Line; Epidermal Growth Factor; Fibroblasts; Humans; Isoenzymes; Mice; Mice, Knockout; Phospholipase C gamma; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-sis; Recombinant Fusion Proteins; src Homology Domains; Type C Phospholipases; Tyrosine; Ubiquitin-Protein Ligases | 2002 |
Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation.
Topics: Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Glucose Oxidase; Humans; Hydrogen Peroxide; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases | 2002 |
GH and epidermal growth factor signaling in normal and Laron syndrome fibroblasts.
Topics: Abnormalities, Multiple; Androstadienes; Blotting, Western; Child; Epidermal Growth Factor; Female; Fibroblasts; Growth Hormone; Humans; Indicators and Reagents; Janus Kinase 2; Luciferases; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatotropin; Signal Transduction; Syndrome; Transfection; Tyrosine; Wortmannin | 2002 |
Mitogen-induced, FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein.
Topics: 3T3 Cells; A Kinase Anchor Proteins; Actins; Animals; Cell Cycle Proteins; Cell Line; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Mice; Mice, Knockout; Mitogens; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Tyrosine | 2002 |
Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF.
Topics: Blotting, Northern; Blotting, Western; Cell Line; Cell Membrane; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epithelium; ErbB Receptors; Helicobacter pylori; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Metalloendopeptidases; Phosphorylation; RNA, Messenger; Signal Transduction; Stomach; Stomach Neoplasms; Time Factors; Transcriptional Activation; Tyrosine | 2002 |
Differential cytoskeletal association of ErbB1 and ErbB2 during keratinocyte differentiation.
Topics: Calibration; Cell Differentiation; Cells, Cultured; Cytoskeleton; Cytosol; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Mitogen-Activated Protein Kinases; Phosphorylation; Receptor, ErbB-2; Subcellular Fractions; Tyrosine | 2002 |
Hyperosmotic stress induces phosphorylation of cytosolic phospholipase A(2) in HaCaT cells by an epidermal growth factor receptor-mediated process.
Topics: Arachidonic Acid; Calcium; Cell Compartmentation; Cell Line, Transformed; Cell Nucleus; Dinoprostone; Drug Eruptions; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipids; Phosphorylation; Phosphotransferases; Protein Serine-Threonine Kinases; Sorbitol; Stress, Physiological; Tyrosine | 2002 |
Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Insulin; Insulin Resistance; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Subcellular Fractions; Transforming Growth Factor alpha; Tyrosine | 2002 |
Lateral propagation of EGF signaling after local stimulation is dependent on receptor density.
Topics: Animals; Bacterial Proteins; Carcinoma; Cell Membrane; COS Cells; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Cells; Gene Expression Regulation; Green Fluorescent Proteins; GTP Phosphohydrolases; Humans; Indicators and Reagents; Luminescent Proteins; Macromolecular Substances; Phosphorylation; Protozoan Proteins; ras Proteins; Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2002 |
Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.
Topics: Calcium; Cell Movement; Dimerization; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Estrenes; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Pyrrolidinones; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 2002 |
Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor.
Topics: Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cytoplasm; Detergents; Dimerization; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Immunoblotting; Keratinocytes; Models, Chemical; Oligonucleotides, Antisense; Phosphorylation; Precipitin Tests; Protein Binding; Serine; Signal Transduction; Tyrosine; Up-Regulation | 2002 |
Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation.
Topics: Androstadienes; Carcinoma, Squamous Cell; Caveolae; Caveolin 1; Caveolins; Cell Line; Chromones; Colchicine; Cyclodextrins; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Kinetics; Morpholines; Nucleic Acid Synthesis Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; src-Family Kinases; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2002 |
EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor.
Topics: Dextrans; Epidermal Growth Factor; ErbB Receptors; Glioma; Humans; Isoenzymes; Phospholipase C gamma; Phosphorylation; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 2002 |
Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication.
Topics: Animals; Cell Communication; Cells, Cultured; Connexin 43; Epidermal Growth Factor; Eukaryotic Cells; Gap Junctions; Isoquinolines; Membrane Potentials; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Pyrimidines; Quaternary Ammonium Compounds; Tyrosine | 2003 |
Bombesin and epidermal growth factor potentiate the effect of cytotoxic LH-RH analog AN-152 in vitro.
Topics: Antineoplastic Agents; Bombesin; Breast Neoplasms; Cell Division; Doxorubicin; Drug Combinations; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Gastrin-Releasing Peptide; Gonadotropin-Releasing Hormone; Humans; In Vitro Techniques; Microscopy, Confocal; Phosphorylation; Receptors, Bombesin; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2002 |
Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Hepatocytes; Insulin-Like Growth Factor Binding Protein 3; Phosphorylation; Rats; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Tyrosine | 2002 |
Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Lysine; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Point Mutation; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tyrosine | 2003 |
Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways.
Topics: DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2003 |
Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formation.
Topics: Animals; Cell Membrane; Cell Surface Extensions; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; rac1 GTP-Binding Protein; Signal Transduction; Type C Phospholipases; Tyrosine | 2003 |
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops.
Topics: Animals; Cell Line; Cricetinae; Cysteine Endopeptidases; Epidermal Growth Factor; ErbB Receptors; Feedback; Humans; Hydrolysis; Multienzyme Complexes; Nerve Tissue Proteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Gab2 tyrosine phosphorylation by a pleckstrin homology domain-independent mechanism: role in epidermal growth factor-induced mitogenesis.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blood Proteins; Cells, Cultured; Cytosol; DNA; Epidermal Growth Factor; Female; Hepatocytes; Macromolecular Substances; Mitogens; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptor, ErbB-3; Sequence Homology, Amino Acid; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 2003 |
Impairment of the EGF signaling pathway by the oxidative stress generated with UVA.
Topics: Antioxidants; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Promoter Regions, Genetic; Reactive Oxygen Species; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factor AP-1; Tyrosine; Ultraviolet Rays; Vitamin E | 2003 |
The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling.
Topics: Amino Acid Motifs; Animals; Calcium; Cell Division; COS Cells; Dose-Response Relationship, Drug; Epidermal Growth Factor; Glutathione; Humans; Immunoblotting; Inositol 1,4,5-Trisphosphate; Mutation; Phospholipase C gamma; Phospholipase D; Phosphorylation; Precipitin Tests; Proline; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Type C Phospholipases; Tyrosine | 2003 |
Neuregulin promotes autophagic cell death of prostate cancer cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Autophagy; Cell Death; Cell Division; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Ligands; Male; Morpholines; Neuregulins; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine | 2003 |
Transmodulation between phospholipase D and c-Src enhances cell proliferation.
Topics: Animals; Carcinoma, Squamous Cell; Catalytic Domain; Cell Division; Cells, Cultured; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Mutation; Paxillin; Phospholipase D; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Tyrosine | 2003 |
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation.
Topics: Cell Cycle; Cell Division; Epidermal Growth Factor; Gene Expression Regulation; HeLa Cells; Humans; Hydrogen Peroxide; Mitochondria; Mutation; Phosphoproteins; Phosphorylation; Tetracycline; Thioredoxin Reductase 2; Thioredoxin-Disulfide Reductase; Tyrosine | 2003 |
Prostate cancer cell proliferation is strongly reduced by the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in vitro on human cell lines and primary cultures.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; In Vitro Techniques; Male; Phosphorylation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrosine | 2003 |
[EGF-induced signal transduction in clonal cells of epidermoid carcinoma A431].
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Division; Clone Cells; DNA-Binding Proteins; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Genetic Variation; Humans; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2003 |
A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biological Transport; Carcinoma, Hepatocellular; Cell Fractionation; Cell Nucleus; Conserved Sequence; COS Cells; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Fluorescent Antibody Technique; Gene Deletion; Gene Expression; Humans; Immunosorbent Techniques; Leucine; Liver Neoplasms; Mice; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Phosphorylation; Polymerase Chain Reaction; Protein Structure, Secondary; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship; Trans-Activators; Transfection; Tumor Cells, Cultured; Tyrosine | 2003 |
Epidermal growth factor increased the expression of alpha2beta1-integrin and modulated integrin-mediated signaling in human cervical adenocarcinoma cells.
Topics: Adenocarcinoma; Antibodies; Cell Movement; Cell Size; Collagen Type IV; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin alpha2beta1; Phosphorylation; Protein-Tyrosine Kinases; Pseudopodia; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Uterine Cervical Neoplasms | 2003 |
Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.
Topics: Actins; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Blotting, Western; Carrier Proteins; Catalysis; Cell Line; COS Cells; Cytoplasm; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Humans; Immunoblotting; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Models, Genetic; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; src Homology Domains; Time Factors; Transfection; Tyrosine | 2003 |
Cbl competitively inhibits epidermal growth factor-induced activation of phospholipase C-gamma1.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; In Vitro Techniques; Oncogene Protein v-cbl; PC12 Cells; Phospholipase C gamma; Phosphorylation; Rats; Retroviridae Proteins, Oncogenic; src Homology Domains; Type C Phospholipases; Tyrosine | 2003 |
Transforming growth factor alpha binds to Trypanosoma cruzi amastigotes to induce signaling and cellular proliferation.
Topics: Animals; Cell Division; DNA; Epidermal Growth Factor; ErbB Receptors; Macrophages; Phosphorylation; Signal Transduction; Transforming Growth Factor alpha; Trypanosoma cruzi; Tyrosine | 2003 |
Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Carrier Proteins; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Membrane Proteins; Phospholipid Transfer Proteins; Phosphorylation; Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src-Family Kinases; Tyrosine | 2003 |
Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.
Topics: Animals; Binding Sites; Cell Division; Cell Line; Cell Separation; Cytokines; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Epidermal Growth Factor; Erythropoietin; Flow Cytometry; Hematopoietic Stem Cells; Mice; Milk Proteins; Models, Genetic; Mutation; Phosphotyrosine; Proto-Oncogene Proteins c-kit; Receptors, Erythropoietin; Retroviridae; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; GRB2 Adaptor Protein; Growth Substances; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Proteins; Somatomedins; Tyrosine | 2003 |
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
Topics: Antibodies; Bronchi; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase Inhibitors; Phosphorylation; Quinazolines; Tyrosine; Zinc | 2004 |
Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Binding, Competitive; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Interleukin-6; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatases; Proteins; Signal Transduction; src Homology Domains; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription, Genetic; Tyrosine | 2003 |
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.
Topics: Animals; Catalysis; cdc42 GTP-Binding Protein; Cell Line; Epidermal Growth Factor; Humans; Oncogene Proteins; Phosphorylation; Proto-Oncogene Proteins c-vav; Signal Transduction; src-Family Kinases; Tyrosine | 2003 |
Basic fibroblast and epidermal growth factors stimulate survival in adult porcine photoreceptor cell cultures.
Topics: Animals; Arrestin; Blotting, Western; Calcium-Binding Proteins; Cell Culture Techniques; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Drug Combinations; Epidermal Growth Factor; Eye Proteins; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; Hippocalcin; Lipoproteins; Nerve Tissue Proteins; Phosphopyruvate Hydratase; Phosphorylation; Photoreceptor Cells, Vertebrate; Recoverin; Rod Opsins; Swine; Tyrosine | 2003 |
GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Angiotensin II; Animals; Calcium; Cell Cycle Proteins; Cell Line; Cells, Cultured; Cloning, Molecular; DNA Mutational Analysis; Enzyme Activation; Epidermal Growth Factor; Gene Deletion; GTPase-Activating Proteins; Humans; Immunoblotting; Mass Spectrometry; Models, Biological; Models, Genetic; Molecular Sequence Data; Muscle, Smooth; Oligonucleotides; Peptides; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Signal Transduction; src-Family Kinases; Transfection; Type C Phospholipases; Tyrosine | 2003 |
[p120(ctn) tyrosine phosphorylation are involved in the biologic behavior changes of hepatocellular carcinoma cells].
Topics: Active Transport, Cell Nucleus; beta Catenin; Carcinoma, Hepatocellular; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cytoskeletal Proteins; Delta Catenin; Epidermal Growth Factor; Humans; Liver Neoplasms; Phosphoproteins; Phosphorylation; Trans-Activators; Transfection; Tyrosine | 2003 |
Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; Ligands; Mass Spectrometry; Phosphoproteins; Proteome; Signal Transduction; Tyrosine | 2003 |
Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.
Topics: Cell Division; Cell Line, Transformed; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; Focal Adhesion Kinase 2; Genes, Dominant; Genes, Reporter; HeLa Cells; Humans; Immunoblotting; Phosphorylation; Phosphotransferases; Plasmids; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 2004 |
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Calcium; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; In Situ Nick-End Labeling; Janus Kinase 1; Luciferases; Mice; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine; Up-Regulation | 2004 |
CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.
Topics: Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Dimerization; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Ligands; MAP Kinase Signaling System; Mice; Models, Biological; Models, Molecular; Mutation; Phosphorylation; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 2004 |
Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, fos; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Stress Fibers; Tyrosine | 2004 |
Generation and characterization of a constitutively active Stat3 protein.
Topics: Animals; COS Cells; DNA; DNA-Binding Proteins; Doxycycline; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Genes, myc; Genes, src; Herpes Simplex Virus Protein Vmw65; Mice; Phosphorylation; Recombinant Proteins; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine | 2004 |
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Cell Division; Cell Line, Tumor; Chromones; Deoxycytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gemcitabine; Humans; Hypoxia; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; NF-kappa B; Nitriles; Oxygen; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tyrosine | 2004 |
Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.
Topics: Carcinoma; Cell Movement; Diet; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Luteolin; Matrix Metalloproteinases; Neoplasm Invasiveness; Phosphorylation; Protein-Tyrosine Kinases; Quercetin; Subcellular Fractions; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2004 |
Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.
Topics: Animals; Antibodies; B-Lymphocytes; Binding Sites; Cell Division; Cell Line; Enzyme Activation; Epidermal Growth Factor; Humans; Hydrolysis; Immunoblotting; Inositol Phosphates; Jurkat Cells; Kinetics; Lipase; Mice; Models, Genetic; Mutation; NIH 3T3 Cells; Phospholipase C gamma; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Rats; T-Lymphocytes; Time Factors; Type C Phospholipases; Tyrosine | 2004 |
Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Betacellulin; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Intercellular Signaling Peptides and Proteins; Ligands; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Son of Sevenless Proteins; src Homology Domains; Tyrosine | 2004 |
Nerve growth factor (NGF) induces a rapid and sustained downregulation of the focal adhesion kinase (FAK).
Topics: Animals; Antibodies; Cell Adhesion; Down-Regulation; Epidermal Growth Factor; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Nerve Growth Factor; Neurons; PC12 Cells; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Rats; Reaction Time; Receptor, trkA; Signal Transduction; src-Family Kinases; Tyrosine | 2004 |
Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; Blotting, Western; Catalytic Domain; Cell Line; COS Cells; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Epitopes; ErbB Receptors; Glutathione Transferase; Kinetics; Ligands; Mice; Peptides; Phosphoproteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Substrate Specificity; Time Factors; Tyrosine | 2004 |
[The relationship between p120ctn translocation and malignant features of hepatocellular carcinoma].
Topics: beta Catenin; Cadherins; Carcinoma, Hepatocellular; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Nucleus; Cell Proliferation; Cytoskeletal Proteins; Cytosol; Delta Catenin; Epidermal Growth Factor; Humans; Liver Neoplasms; Phosphoproteins; Phosphorylation; Protein Transport; Trans-Activators; Tyrosine | 2004 |
Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion.
Topics: beta Catenin; Blotting, Northern; Cadherins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Intercellular Junctions; Mouth Neoplasms; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Signal Transduction; Trans-Activators; Tyrosine | 2004 |
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.
Topics: Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Lysosomes; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Cell Line; Cell Line, Tumor; Cell Nucleus; Down-Regulation; Epidermal Growth Factor; Glutathione Transferase; Humans; Immunoprecipitation; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mutation; Phosphoproteins; Phosphorylation; Plasmids; Platelet-Derived Growth Factor; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Time Factors; Transfection; Two-Hybrid System Techniques; Tyrosine | 2004 |
Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adenoviridae; Adipocytes; Animals; Cell Differentiation; Epidermal Growth Factor; Genetic Vectors; GRB2 Adaptor Protein; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Insulin; Ligands; MAP Kinase Signaling System; Mice; Mutation; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Platelet-Derived Growth Factor; Proline; Protein Binding; Protein Structure, Tertiary; ras GTPase-Activating Proteins; ras Proteins; Rats; Signal Transduction; Swine; Time Factors; Transfection; Tyrosine | 2005 |
Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons.
Topics: Animals; Binding Sites; Cell Differentiation; Cells, Cultured; Cerebral Cortex; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neural Pathways; Neurites; Neurons; Phosphorylation; Repressor Proteins; Spheroids, Cellular; src-Family Kinases; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Tyrosine | 2004 |
Role of ErbB2 in Corneal Epithelial Wound Healing.
Topics: Cell Line, Transformed; Cell Membrane; Cell Movement; Coated Materials, Biocompatible; Collagen Type I; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Eye Injuries; Fibronectins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Membranes, Artificial; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptor, ErbB-2; Tyrosine; Wound Healing; Wounds, Penetrating | 2004 |
Common and distinct elements in cellular signaling via EGF and FGF receptors.
Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Dimerization; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factors; Heparan Sulfate Proteoglycans; Humans; Ligands; Phosphorylation; Receptors, Fibroblast Growth Factor; Second Messenger Systems; Signal Transduction; Tyrosine | 2004 |
A 120 kDa nuclear phospholipase Cgamma1 protein fragment is stimulated in vivo by EGF signal phosphorylating nuclear membrane EGFR.
Topics: Animals; Cell Nucleus; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Liver; Mice; Nuclear Envelope; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phospholipase C gamma; Phosphorylation; Signal Transduction; Type C Phospholipases; Tyrosine | 2004 |
Src-dependent ezrin phosphorylation in adhesion-mediated signaling.
Topics: Actins; Catalysis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Collagen; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Factor; Feedback, Physiological; Fibronectins; Glutathione Transferase; Humans; Immunoprecipitation; Microscopy, Fluorescence; Models, Biological; Mutation; Phosphoproteins; Phosphorylation; Plasmids; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src Homology Domains; src-Family Kinases; Tyrosine | 2005 |
Growth factors stimulate kidney proximal tubule cell migration independent of augmented tyrosine phosphorylation of focal adhesion kinase.
Topics: 3T3 Cells; Animals; Cell Line; Cell Movement; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Growth Substances; Hepatocyte Growth Factor; Humans; Insulin-Like Growth Factor I; Kidney Tubules, Proximal; Mice; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine | 2005 |
Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine.
Topics: Acetaldehyde; Adherens Junctions; Colon; Detergents; Drug Interactions; Epidermal Growth Factor; Female; Glutamine; Humans; In Vitro Techniques; Intestinal Mucosa; Male; Phosphorylation; Solubility; Tight Junctions; Tyrosine | 2005 |
Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
Topics: Amphiregulin; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Screening Assays, Antitumor; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8; Irinotecan; Phosphorylation; Quinazolines; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms; Transforming Growth Factor alpha; Tyrosine | 2005 |
Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anoikis; Breast Neoplasms; CSK Tyrosine-Protein Kinase; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Tyrosine | 2005 |
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.
Topics: Amino Acid Sequence; Animals; Biotin; Blood Platelets; Blotting, Western; Cell Communication; Cell Line; Cloning, Molecular; COS Cells; Cross-Linking Reagents; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Epidermal Growth Factor; Eptifibatide; Flow Cytometry; Humans; Immunoprecipitation; Mass Spectrometry; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Peptides; Peroxidase; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Signal Transduction; Threonine; Tissue Distribution; Transfection; Tyrosine | 2005 |
Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.
Topics: Blotting, Western; Calcium; Cell Differentiation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Genes, Dominant; Humans; Immunoprecipitation; Keratinocytes; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Protein Precursors; src-Family Kinases; Time Factors; Transfection; Transglutaminases; Tyrosine | 2005 |
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Topics: Animals; Aspartic Acid; Cell Line; Cell Membrane; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hippocampus; Humans; Immunoprecipitation; MAP Kinase Signaling System; Models, Biological; Mutation; Neurons; Phosphatidylethanolamine Binding Protein; Phosphorylation; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Rats; RNA; RNA, Small Interfering; Serine; Signal Transduction; Time Factors; Tyrosine | 2005 |
A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.
Topics: Animals; Antibodies, Monoclonal; Chlorocebus aethiops; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Immunoblotting; Kinetics; Microscopy, Video; Molecular Probes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Quinazolines; Tyrosine; Tyrphostins | 2005 |
GIT1 is a scaffold for ERK1/2 activation in focal adhesions.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Line; Cell Movement; Chemotaxis; Cytoskeleton; Enzyme Activation; Epidermal Growth Factor; Focal Adhesions; GTPase-Activating Proteins; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphoproteins; Phosphorylation; Plasmids; Protein Binding; Protein Structure, Tertiary; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Subcellular Fractions; Time Factors; Transfection; Tyrosine | 2005 |
Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation.
Topics: Cell Differentiation; Cell Line; Epidermal Growth Factor; Fibroblast Growth Factors; Humans; MAP Kinase Signaling System; Mesoderm; Nerve Growth Factor; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proteins; Proteomics; Signal Transduction; Stem Cells; Tyrosine | 2005 |
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1.
Topics: Adaptor Proteins, Signal Transducing; Calcium; Cell Line; Epidermal Growth Factor; Gene Expression; GRB2 Adaptor Protein; Humans; Inositol 1,4,5-Trisphosphate; Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; ras Proteins; RNA, Small Interfering; Signal Transduction; Transfection; Type C Phospholipases; Tyrosine | 2005 |
Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.
Topics: Atherosclerosis; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Humans; Inflammation; Models, Biological; Mutation; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Receptor, PAR-1; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; src-Family Kinases; Threonine; Thrombin; Thrombomodulin; Time Factors; Tyrosine; Umbilical Veins | 2005 |
Inhibition of epidermal growth factor-induced cell transformation by tannins.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Tannins; Tyrosine | 2005 |
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Topics: Benzamides; beta-Galactosidase; Breast Neoplasms; Cellular Senescence; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Histone Deacetylase Inhibitors; Humans; Insulin-Like Growth Factor I; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthols; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Sirtuin 1; Sirtuins; Tumor Cells, Cultured; Tyrosine | 2006 |
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Animals, Newborn; Astrocytes; Brain; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cells, Cultured; Disease Progression; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Fluorescent Antibody Technique, Indirect; Genetic Vectors; HeLa Cells; Humans; Immunoprecipitation; Microscopy, Fluorescence; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Peptides; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; RNA Interference; RNA-Binding Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine | 2005 |
Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation.
Topics: Actins; Animals; Chlorocebus aethiops; COS Cells; Cytoskeletal Proteins; DNA-Binding Proteins; Epidermal Growth Factor; Focal Adhesions; Humans; LIM Domain Proteins; Mice; Mutation; Paxillin; Phosphorylation; Pseudopodia; rac GTP-Binding Proteins; Tyrosine | 2005 |
Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor.
Topics: Adenoviridae; Adherens Junctions; Animals; beta Catenin; Blotting, Western; Cell Adhesion; Cells, Cultured; Desmosomes; Detergents; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; gamma Catenin; Green Fluorescent Proteins; Immunoprecipitation; Keratinocytes; Mice; Mice, Knockout; Microscopy, Fluorescence; Neoplasm Metastasis; Octoxynol; Phosphorylation; Protein Structure, Tertiary; Signal Transduction; Time Factors; Tyrosine; Wound Healing | 2005 |
Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.
Topics: Animals; Calcium; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Gastrointestinal Hormones; Growth Substances; Hepatocyte Growth Factor; In Vitro Techniques; Male; Pancreas; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2006 |
Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Immunoprecipitation; Lung Neoplasms; Mutation; Phosphorylation; Quinazolines; Tumor Cells, Cultured; Tyrosine; Ubiquitin | 2006 |
Activated EGF receptor may balance ERK-inhibitory network signalling pathways.
Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Mutation; Phenylalanine; Phosphorylation; Receptor, Bradykinin B2; Receptors, Adrenergic, beta-2; Signal Transduction; src-Family Kinases; Tyrosine | 2006 |
Impaired generation of reactive oxygen species in leprechaunism through downregulation of Nox4.
Topics: Abnormalities, Multiple; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Insulin Resistance; NADPH Oxidase 4; NADPH Oxidases; Phenotype; Phosphorylation; Platelet-Derived Growth Factor; Reactive Oxygen Species; Tyrosine | 2005 |
Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth.
Topics: beta-Adrenergic Receptor Kinases; Bronchi; Cells, Cultured; Epidermal Growth Factor; G-Protein-Coupled Receptor Kinase 2; Humans; Mitosis; Muscle, Smooth; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thrombin; Tyrosine | 2005 |
Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells.
Topics: Animals; Blotting, Western; Caveolin 1; Cell Line; Cell Line, Tumor; Cell Membrane; Centrifugation, Density Gradient; Cytoplasm; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Humans; Immunoprecipitation; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microscopy, Immunoelectron; Mutation; Phosphorylation; Rats; Sucrose; Time Factors; Transfection; Tyrosine | 2006 |
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.
Topics: Animals; Catalysis; Caveolin 1; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Insulin; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Signal Transduction; src-Family Kinases; Substrate Specificity; Tyrosine | 2006 |
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays | 2006 |
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling.
Topics: Animals; Cell Line; Chickens; CSK Tyrosine-Protein Kinase; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Phosphorylation; Protein-Tyrosine Kinases; Rats; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; src-Family Kinases; Tyrosine; Vault Ribonucleoprotein Particles | 2006 |
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
Topics: Cell Line, Tumor; Cell Movement; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Oligopeptides; Phosphorylation; Pyrroles; Quinazolines; Receptor, PAR-1; Thrombin; Tyrosine; Tyrphostins | 2006 |
The molecular mechanism of EGF receptor activation in pancreatic beta-cells by thyrotropin-releasing hormone.
Topics: Animals; Antibodies; Base Sequence; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; GTP-Binding Protein beta Subunits; Heparin-binding EGF-like Growth Factor; Insulin-Secreting Cells; Intercellular Signaling Peptides and Proteins; Models, Biological; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Pyrimidines; Receptors, Thyrotropin-Releasing Hormone; Signal Transduction; src-Family Kinases; Thyrotropin-Releasing Hormone; Tyrosine | 2006 |
A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Colchicine; Cytochalasin D; Cytoskeleton; Epidermal Growth Factor; Humans; Kinesins; Microtubules; Phosphorylation; STAT5 Transcription Factor; Tubulin; Tyrosine | 2006 |
Pike tyrosine phosphorylation regulates its apoptotic cleavage during programmed cell death.
Topics: Apoptosis; Cell Line; Epidermal Growth Factor; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Phosphorylation; Tyrosine | 2006 |
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; Cetuximab; Cisplatin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins | 2006 |
Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
Topics: Amino Acid Substitution; Animals; Cell Line; Chlorocebus aethiops; COS Cells; Culture Media, Serum-Free; Endocytosis; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fluorescent Dyes; Humans; Ligands; Models, Biological; Phenylalanine; Phosphorylation; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-cbl; Rhodamines; Time Factors; Tyrosine | 2006 |
Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; DNA Topoisomerases, Type II; Down-Regulation; Drug Resistance, Neoplasm; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Oligonucleotides; Phosphorylation; Tetrazolium Salts; Thiazoles; Tyrosine | 2006 |
Urokinase receptor primes cells to proliferate in response to epidermal growth factor.
Topics: Animals; Autocrine Communication; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Plasminogen; Protein Binding; Proto-Oncogene Proteins pp60(c-src); Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; STAT5 Transcription Factor; Tyrosine; Urokinase-Type Plasminogen Activator | 2007 |
Regulation of androgen receptor activity by tyrosine phosphorylation.
Topics: Androgens; Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Dihydrotestosterone; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Indoles; Interleukin-6; Kinetics; Male; Mice; Mice, SCID; Neuregulin-1; Phosphorylation; Prostatic Neoplasms; Pyrimidines; Receptors, Androgen; src-Family Kinases; Sulfonamides; Tyrosine; Xenograft Model Antitumor Assays | 2006 |
Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.
Topics: Adaptor Proteins, Signal Transducing; Cells, Cultured; Epidermal Growth Factor; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-cbl; Repressor Proteins; RNA Interference; Tyrosine; Ubiquitin; Vanadates | 2006 |
Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.
Topics: Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Survival; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; fas Receptor; Fatty Acid Synthases; Female; Flow Cytometry; Genes, erbB-2; Humans; Immunoprecipitation; Naphthoquinones; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Stimulation, Chemical; Translocation, Genetic; Tyrosine | 2007 |
CD95 tyrosine phosphorylation is required for CD95 oligomerization.
Topics: Animals; Apoptosis; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Fas Ligand Protein; fas Receptor; Fluorescence Resonance Energy Transfer; Humans; Luminescent Proteins; Mice; Phosphorylation; Protein Structure, Quaternary; Recombinant Fusion Proteins; Tyrosine | 2007 |
Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton.
Topics: Actins; Animals; Cell Adhesion; Cell Line; Cell Membrane; Cytoskeleton; Endosomes; Epidermal Growth Factor; Fibroblasts; Fibronectins; HeLa Cells; Humans; Membrane Proteins; Mice; PC12 Cells; Phosphorylation; Rats; Recombinant Fusion Proteins; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Transfection; Tyrosine | 2007 |
Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.
Topics: Actins; Animals; Caco-2 Cells; Cell Membrane; Cell Movement; Dogs; Epidermal Growth Factor; Epithelial Cells; Estrenes; Fluorescence Resonance Energy Transfer; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Mice; Microfilament Proteins; Mutation; Phospholipase C gamma; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Pyrrolidinones; RNA, Small Interfering; Signal Transduction; src Homology Domains; src-Family Kinases; Transfection; Tyrosine; Wound Healing | 2007 |
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.
Topics: Angiotensins; Animals; Carbachol; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intestinal Mucosa; Ionomycin; Kinetics; Lysophospholipids; Phosphorylation; Protein Kinase C; Rats; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Tyrosine | 2007 |
Crosstalk between EGFR and extranuclear steroid receptors.
Topics: Androgen Receptor Antagonists; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Humans; Male; Phosphorylation; Prostatic Neoplasms; Receptor Cross-Talk; Receptors, Androgen; Receptors, Steroid; Signal Transduction; src-Family Kinases; Tyrosine; Up-Regulation | 2006 |
Apical epidermal growth factor receptor signaling: regulation of stretch-dependent exocytosis in bladder umbrella cells.
Topics: Animals; Antibodies, Monoclonal; Cell Membrane; Cycloheximide; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Exocytosis; Female; Glycoproteins; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Mucous Membrane; Phosphorylation; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Signal Transduction; Transforming Growth Factor alpha; Tyrosine; Urinary Bladder | 2007 |
p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism.
Topics: Base Sequence; Carcinoma, Squamous Cell; Catenins; Cell Adhesion Molecules; Cell Line, Tumor; Delta Catenin; DNA Primers; Epidermal Growth Factor; Humans; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Recombinant Proteins; RNA, Small Interfering; Tyrosine | 2007 |
Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation.
Topics: Animals; Cells, Cultured; Electric Conductivity; Epidermal Growth Factor; ErbB Receptors; Humans; Hydrolysis; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Kidney; Membranes; Neurons; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphorylation; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tyrosine | 2007 |
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Topics: Cell Culture Techniques; Cells, Cultured; Cluster Analysis; Endothelium, Vascular; Epidermal Growth Factor; Epithelial Cells; Female; Humans; Kinetics; Mammary Glands, Human; Mass Spectrometry; Peptides; Phosphorylation; Proteome; Proteomics; Reproducibility of Results; Sequence Analysis, Protein; Signal Transduction; Tyrosine | 2007 |
Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.
Topics: Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Drug Resistance, Neoplasm; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ligands; Mice; Mutation; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-cbl; Quinazolines; Sequence Deletion; Tyrosine; Ubiquitin | 2007 |
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; I-kappa B Kinase; NF-kappa B; Phosphorylation; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitination | 2007 |
Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.
Topics: Amino Acid Substitution; Animals; Cell Adhesion; Chlorocebus aethiops; COS Cells; DNA Mutational Analysis; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Mutation; Neoplasm Proteins; Phenylalanine; Phosphorylation; rac GTP-Binding Proteins; src-Family Kinases; Transfection; Tyrosine | 2007 |
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration.
Topics: Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; HeLa Cells; Humans; Hydrolysis; Models, Biological; Mutation; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Recombinant Proteins; Talin; Tyrosine | 2007 |
EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Fragmentation; Electrophoresis, Agar Gel; Epidermal Growth Factor; Humans; Phosphorylation; RNA, Small Interfering; Signal Transduction; src-Family Kinases; STAT1 Transcription Factor; STAT3 Transcription Factor; Tyrosine | 2007 |
Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Histone Acetyltransferases; Humans; Immunoprecipitation; Nuclear Receptor Coactivator 3; Phosphorylation; Receptor, ErbB-3; Receptor, Platelet-Derived Growth Factor beta; RNA, Small Interfering; Signal Transduction; Trans-Activators; Tyrosine | 2007 |
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2007 |
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblasts; Humans; Membrane Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Serine; Tamoxifen; Tyrosine; Ubiquitin; Vanadates | 2007 |
Identification of the domain in ErbB2 that restricts ligand-induced degradation.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Endocytosis; Epidermal Growth Factor; Humans; Ligands; Molecular Sequence Data; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-cbl; Receptor, ErbB-2; Recombinant Fusion Proteins; Transfection; Tyrosine; Ubiquitin | 2008 |
S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation.
Topics: Animals; Blotting, Western; Breast Neoplasms; Calcium-Binding Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Down-Regulation; Drug Combinations; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunoblotting; Interleukin-8; Laminin; Mice; Mice, SCID; Neovascularization, Pathologic; Osteoclasts; Osteolysis; Phosphorylation; Proteoglycans; Receptor, ErbB-2; S100 Calcium Binding Protein A7; S100 Proteins; Signal Transduction; Tyrosine | 2008 |
Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF.
Topics: Amino Acid Sequence; Cell Line, Tumor; Cells, Cultured; Epidermal Growth Factor; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Models, Biological; Molecular Sequence Data; Phosphorylation; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; Rho Guanine Nucleotide Exchange Factors; RNA, Small Interfering; Sequence Homology, Amino Acid; Son of Sevenless Protein, Drosophila; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Tyrosine | 2008 |
Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements.
Topics: Animals; Antineoplastic Agents; Carcinoma, Medullary; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Germ-Line Mutation; Humans; Mice; Mice, Nude; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Oncogene Proteins; Phosphorylation; Proteomics; Proto-Oncogene Proteins c-ret; Quinazolines; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2009 |
Escherichia coli expression and refolding of E/K-coil-tagged EGF generates fully bioactive EGF for diverse applications.
Topics: Cell Line, Tumor; Cells, Cultured; Dimerization; Epidermal Growth Factor; ErbB Receptors; Escherichia coli; Gene Expression; Humans; Inclusion Bodies; Peptides; Phosphorylation; Protein Folding; Recombinant Proteins; Surface Plasmon Resonance; Tissue Engineering; Tyrosine | 2009 |
Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling.
Topics: Actins; Animals; Apoptosis Regulatory Proteins; Cell Line; Cell Movement; Cytoskeleton; Endothelial Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Membrane Proteins; Models, Biological; Phosphorylation; Rats; Signal Transduction; Tyrosine; Zebrafish | 2009 |
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.
Topics: Animals; Breast Neoplasms; Cell Communication; Cell Differentiation; Cell Line; Cell Proliferation; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; GRB2 Adaptor Protein; Humans; Janus Kinase 2; Mammary Glands, Human; MAP Kinase Signaling System; Phosphorylation; Prolactin; ras Proteins; STAT5 Transcription Factor; Tumor Suppressor Proteins; Tyrosine | 2009 |
A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoglobulin Fc Fragments; Phosphorylation; Recombinant Fusion Proteins; Tyrosine; Xenograft Model Antitumor Assays | 2009 |
Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.
Topics: Animals; Cell Adhesion; Cell Culture Techniques; Cell Membrane; Cell Surface Extensions; Cells, Cultured; Cortactin; Epidermal Growth Factor; Focal Adhesion Protein-Tyrosine Kinases; Hepatocytes; Humans; Phosphorylation; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Tyrosine | 2009 |
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.
Topics: Animals; Cell Line; Cell Movement; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblasts; Focal Adhesion Kinase 1; Insulin-Like Growth Factor I; Lysophospholipids; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 2009 |
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Topics: Algorithms; Amino Acid Motifs; Cell Line; Chromatography, Liquid; Epidermal Growth Factor; Epithelial Cells; Humans; Mammary Glands, Human; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Interaction Mapping; Proteome; Signal Transduction; Tandem Mass Spectrometry; Tyrosine | 2009 |
A reduction of epidermal growth factor receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human astrocytoma cells.
Topics: Amides; Animals; Antineoplastic Agents; Astrocytoma; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Phenols; Phosphorylation; Signal Transduction; Tyrosine | 2009 |
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.
Topics: Actin Depolymerizing Factors; Actin-Related Protein 2-3 Complex; Actins; Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Cortactin; Epidermal Growth Factor; Extracellular Matrix; Humans; Mammary Neoplasms, Animal; Matrix Metalloproteinase 14; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Oncogene Proteins; Phosphorylation; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; RNA, Small Interfering; Tyrosine; Wiskott-Aldrich Syndrome Protein, Neuronal | 2009 |
In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling.
Topics: Chromatography, Liquid; Epidermal Growth Factor; HeLa Cells; Humans; Isotope Labeling; Mass Spectrometry; Phosphoproteins; Phosphorylation; Proteomics; Reproducibility of Results; Tyrosine | 2010 |
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; Endocytosis; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mice; Models, Biological; Mutant Proteins; Phosphorylation; Protein Binding; RNA, Small Interfering; Tyrosine; Up-Regulation | 2009 |
EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cell Line; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; MAP Kinase Signaling System; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Serine Endopeptidases; Tyrosine | 2010 |
Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin.
Topics: Actinin; Actins; Animals; Calpain; Cell Adhesion; Cell Line; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Giant Cells; Humans; MAP Kinase Signaling System; Mice; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Tyrosine | 2010 |
In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays.
Topics: Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Fluorescence Resonance Energy Transfer; Humans; Microscopy, Fluorescence; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tyrosine | 2010 |
Gambogic acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor β tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells.
Topics: Animals; Becaplermin; Cell Cycle; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclins; DNA; Epidermal Growth Factor; G1 Phase; Myocytes, Smooth Muscle; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; rac1 GTP-Binding Protein; Rats; Receptor, Platelet-Derived Growth Factor beta; Resting Phase, Cell Cycle; Signal Transduction; Tyrosine; Xanthones | 2010 |
Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.
Topics: Animals; Carrier Proteins; Cell Line; Cell Line, Tumor; Epidermal Growth Factor; Gene Expression Regulation; Humans; Mice; Microfilament Proteins; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; src Homology Domains; src-Family Kinases; Tyrosine | 2010 |
Antisense inhibition of amphiregulin expression reduces EGFR phosphorylation in transformed human breast epithelial cells.
Topics: Amphiregulin; Antisense Elements (Genetics); Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Phosphorylation; Tyrosine | 2010 |
Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; Humans; Lysine; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Subunits; Tyrosine; Ubiquitination; Vesicular Transport Proteins | 2010 |
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
Topics: Actins; Blotting, Western; Cell Line, Tumor; Cell Movement; Cortactin; Epidermal Growth Factor; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Dynamics Simulation; Neoplasms; Phosphorylation; Protein Conformation; Pseudopodia; RNA Interference; Serine; Tyrosine; Wiskott-Aldrich Syndrome Protein | 2010 |
Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.
Topics: Algorithms; Amino Acid Substitution; Animals; Blotting, Western; Cell Line; Chromatography, Liquid; Computer Simulation; Epidermal Growth Factor; ErbB Receptors; Humans; Mass Spectrometry; Models, Biological; Mutation; Phosphoproteins; Phosphorylation; Proteome; Proteomics; Signal Transduction; Tyrosine | 2010 |
Regenerating islet-derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer.
Topics: Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Growth Processes; Cell Line, Tumor; Drug Resistance, Neoplasm; Epidermal Growth Factor; Gene Knockdown Techniques; HCT116 Cells; Heat-Shock Proteins; HEK293 Cells; HSP27 Heat-Shock Proteins; Humans; Insulin; Lectins, C-Type; Mitogen-Activated Protein Kinases; Molecular Chaperones; Neoplasms; Pancreatitis-Associated Proteins; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Up-Regulation | 2012 |
STAT6 expression in glioblastoma promotes invasive growth.
Topics: Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Databases, Factual; Epidermal Growth Factor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Glioma; Humans; Neoplasm Invasiveness; Phosphorylation; RNA, Small Interfering; STAT6 Transcription Factor; Survival Analysis; Tyrosine | 2011 |
Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution.
Topics: Animals; Binding Sites; Cell Line; Chemotaxis; Colon; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; GRB2 Adaptor Protein; Mice; Mutation; p38 Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; Proto-Oncogene Proteins c-cbl; RNA, Small Interfering; Signal Transduction; src Homology Domains; src-Family Kinases; Transfection; Tyrosine; Wound Healing | 2011 |
Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia.
Topics: Cell Line; Cell Migration Assays; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Gene Knockdown Techniques; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phospholipase C gamma; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Respiratory Mucosa; RNA, Small Interfering; Signal Transduction; Tyrosine | 2011 |
Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation.
Topics: Animals; Chlorocebus aethiops; COS Cells; Dimerization; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Hydrogen Peroxide; Interferon-gamma; Janus Kinase 2; Mass Spectrometry; Mice; Mice, Knockout; Mutation; Phosphorylation; Plasmids; Protein Binding; Signal Transduction; STAT1 Transcription Factor; Transcription, Genetic; Transfection; Tyrosine; Vaccinia virus | 2011 |
Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids.
Topics: Amino Acid Substitution; Amino Acids; Animals; Autoantibodies; CD4-Positive T-Lymphocytes; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epitopes; Female; Immune Tolerance; Immunization; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mutant Proteins; Phenylalanine; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Elevated NRD1 metalloprotease expression plays a role in breast cancer growth and proliferation.
Topics: Apoptosis; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Disease Progression; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunohistochemistry; Metalloproteases; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tyrosine; Up-Regulation | 2011 |
β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.
Topics: Animals; Cell Adhesion; Cell Line; Cell Membrane; Cell Movement; Epidermal Growth Factor; Epithelial Cells; Epithelial-Mesenchymal Transition; ErbB Receptors; Fibronectins; Focal Adhesions; GTPase-Activating Proteins; Integrin beta3; Mammary Glands, Animal; Mice; Mutation; NIH 3T3 Cells; p120 GTPase Activating Protein; Phosphorylation; Pseudopodia; Receptor Cross-Talk; rhoA GTP-Binding Protein; Signal Transduction; Stress Fibers; Tyrosine | 2011 |
Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.
Topics: Cell Line, Tumor; Cell Nucleus; Cyclic GMP-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Oncogene Protein p21(ras); Phosphorylation; Protein Binding; Protein Transport; Proto-Oncogene Proteins c-raf; SOS1 Protein; Stomach Neoplasms; Thymidine; Tyrosine | 2012 |
ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Cell Membrane; Cell Movement; Chlorocebus aethiops; COS Cells; Cytoskeletal Proteins; Cytoskeleton; Epidermal Growth Factor; GRB2 Adaptor Protein; GTPase-Activating Proteins; HeLa Cells; Humans; Integrin beta1; Integrins; Neoplasm Metastasis; Phosphorylation; Tyrosine | 2011 |
Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.
Topics: Animals; Binding Sites; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; MAP Kinase Signaling System; Mutation; Neurites; PC12 Cells; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Structure, Tertiary; Protein Subunits; ras Proteins; Rats; Repressor Proteins; Tyrosine; Ubiquitination | 2012 |
EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR.
Topics: Amino Acid Substitution; Bacterial Outer Membrane Proteins; Binding Sites; Down-Regulation; Endosomes; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Escherichia coli Proteins; Feedback, Physiological; Guanosine Triphosphate; HeLa Cells; Humans; Movement; Mutagenesis; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; RNA; Sequence Deletion; Tyrosine | 2012 |
Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.
Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Binding; Protein Transport; Proteolysis; Proto-Oncogene Proteins c-cbl; Signal Transduction; Tyrosine; Ubiquitination | 2012 |
Inhibitory effect of SPE-39 due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells.
Topics: Animals; Carrier Proteins; Chlorocebus aethiops; COS Cells; DNA, Complementary; Epidermal Growth Factor; Gene Expression Regulation; Humans; Microscopy, Fluorescence; Phosphorylation; Protein Binding; Protein Interaction Mapping; Protein Structure, Tertiary; Time Factors; Tyrosine; Ubiquitin; Vesicular Transport Proteins | 2012 |
EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung cancer cell growth.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Serine; Tandem Mass Spectrometry; Tyrosine | 2012 |
Involvement of the Src-cortactin pathway in migration induced by IGF-1 and EGF in human breast cancer cells.
Topics: Actins; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Movement; Cortactin; Epidermal Growth Factor; Female; Focal Adhesions; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Phosphorylation; Protein Transport; Signal Transduction; src-Family Kinases; Tyrosine | 2012 |
p38 MAP kinase enhances EGF-induced apoptosis in A431 carcinoma cells by promoting tyrosine phosphorylation of STAT1.
Topics: Apoptosis; Cell Line, Tumor; Epidermal Growth Factor; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; STAT1 Transcription Factor; Tyrosine | 2013 |
Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor.
Topics: Adenoma, Islet Cell; Animals; Blotting, Western; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gastrointestinal Hormones; Humans; Neuroendocrine Tumors; Pancreatic Neoplasms; Phosphorylation; Rats; Reactive Oxygen Species; Signal Transduction; Somatostatinoma; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 2013 |
The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation.
Topics: 14-3-3 Proteins; Endopeptidases; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Mutagenesis; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Serine; src-Family Kinases; Transforming Growth Factor alpha; Tyrosine; Ubiquitin Thiolesterase | 2013 |
PTPα-mediated Src activation by EGF in human breast cancer cells.
Topics: Acetophenones; Benzopyrans; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Immunoblotting; Mutation; Phosphorylation; Protein Binding; Protein Kinase C-delta; Proto-Oncogene Proteins pp60(c-src); Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA Interference; Serine; Signal Transduction; Tyrosine | 2013 |
CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.
Topics: Cell Line; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; HCT116 Cells; HEK293 Cells; Humans; Ligands; Lung Neoplasms; Microfilament Proteins; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Proteolysis; Proto-Oncogene Proteins c-cbl; RNA, Messenger; Signal Transduction; src Homology Domains; Tensins; Tyrosine; Ubiquitination | 2013 |
Grb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.
Topics: Animals; Cell Line, Tumor; Cell Surface Extensions; Epidermal Growth Factor; Filamins; Gene Knockdown Techniques; GRB7 Adaptor Protein; Humans; Mice; Models, Molecular; Mutant Proteins; Mutation; Protein Binding; Protein Structure, Tertiary; Two-Hybrid System Techniques; Tyrosine; Wound Healing | 2013 |
Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Epidermal Growth Factor; HEK293 Cells; HeLa Cells; Humans; Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; STAT3 Transcription Factor; Tyrosine; Up-Regulation | 2014 |
Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Carbohydrate Metabolism; Catalytic Domain; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Oxidative Phosphorylation; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Pyruvate Dehydrogenase (Lipoamide); Pyruvic Acid; Receptor, Fibroblast Growth Factor, Type 1; Tumor Burden; Tyrosine | 2014 |
Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.
Topics: DNA, Complementary; Endocytosis; Endosomal Sorting Complexes Required for Transport; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Gene Knockdown Techniques; HeLa Cells; Humans; Immunoprecipitation; Models, Molecular; Mutagenesis, Site-Directed; Nedd4 Ubiquitin Protein Ligases; Phosphorylation; Proteolysis; Real-Time Polymerase Chain Reaction; Receptor Cross-Talk; Receptor, Fibroblast Growth Factor, Type 1; Tandem Mass Spectrometry; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination | 2014 |
CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases.
Topics: Antigens, CD; Antigens, Neoplasm; Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; Female; HEK293 Cells; Humans; Neoplasm Proteins; Phosphorylation; Protein Kinase C; src-Family Kinases; Tyrosine | 2015 |
Regulation of Yin Yang 1 by Tyrosine Phosphorylation.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Epidermal Growth Factor; Gene Expression; HEK293 Cells; HeLa Cells; Humans; Imatinib Mesylate; Indoles; Jurkat Cells; Mutation; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; src-Family Kinases; Sulfonamides; Tyrosine; YY1 Transcription Factor | 2015 |
The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency.
Topics: Cell Line; Epidermal Growth Factor; ErbB Receptors; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Ketocholesterols; Membrane Microdomains; Phloretin; Point Mutation; Protein Domains; Receptor, ErbB-2; Signal Transduction; Tyrosine | 2016 |
Sensitive Approaches for the Assay of the Global Protein Tyrosine Phosphorylation in Complex Samples Using a Mutated SH2 Domain.
Topics: Blotting, Western; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; src Homology Domains; Tyrosine | 2017 |
Tyrosine phosphorylation of Rab7 by Src kinase.
Topics: Adaptor Proteins, Signal Transducing; Cell Membrane; Endosomes; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Lysosomes; Phosphorylation; Protein Binding; Protein Transport; Proteolysis; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Signal Transduction; src-Family Kinases; Tyrosine | 2017 |
Ezrin/NF-kB activation regulates epithelial- mesenchymal transition induced by EGF and promotes metastasis of colorectal cancer.
Topics: Animals; Cell Movement; Colorectal Neoplasms; Cytoskeletal Proteins; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; Female; Humans; Male; Mice, Nude; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Neoplasm Transplantation; NF-kappa B; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Recombinant Fusion Proteins; RNA Interference; Survival Analysis; Tumor Burden; Tyrosine | 2017 |
Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amino Acid Substitution; Animals; CHO Cells; Conserved Sequence; Cricetulus; Dimerization; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Ligands; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Interaction Domains and Motifs; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; Tyrosine | 2017 |
Subcellular distribution of ERK phosphorylation in tyrosine and threonine depends on redox status in murine lung cells.
Topics: Animals; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; Lung; Male; Mice; Mitochondria; Mitogen-Activated Protein Kinase 1; Oxidation-Reduction; Phosphorylation; Subcellular Fractions; Threonine; Tyrosine | 2018 |
The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Epidermal Growth Factor; ErbB Receptors; fas Receptor; HCT116 Cells; Humans; Neoplasm Recurrence, Local; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2018 |
PPARδ is a regulator of autophagy by its phosphorylation.
Topics: Autophagy; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Gefitinib; HCT116 Cells; Humans; Microtubule-Associated Proteins; Mutation; Phosphorylation; PPAR delta; Protein Binding; Protein Kinase Inhibitors; Tyrosine | 2020 |
Autophosphorylation of EGFR at Y954 Facilitated Homodimerization and Enhanced Downstream Signals.
Topics: Dimerization; Epidermal Growth Factor; ErbB Receptors; Phosphorylation; Signal Transduction; Tyrosine | 2020 |
A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes.
Topics: Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Kallmann Syndrome; Lung; MAP Kinase Signaling System; Mutation; Nerve Tissue Proteins; Osteosarcoma; Phosphorylation; Signal Transduction; Tyrosine | 2021 |
Assessing the activation/inhibition of tyrosine kinase-related pathways with a newly developed platform.
Topics: Epidermal Growth Factor; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 2021 |
EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; N-Acetylglucosaminyltransferases; Neoplasms; Phosphorylation; Phosphotyrosine; Pyruvate Kinase; STAT5 Transcription Factor; Tyrosine | 2022 |
Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway.
Topics: Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; MAP Kinase Signaling System; Mice; Ovarian Neoplasms; Phosphorylation; Tyrosine | 2023 |
Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
Topics: Epidermal Growth Factor; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Tyrosine; Ubiquitin-Protein Ligases | 2023 |
Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network.
Topics: Epidermal Growth Factor; ErbB Receptors; Phosphorylation; Signal Transduction; Tyrosine | 2023 |