tyrosine has been researched along with dichloroacetic acid in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Cheung, J; Cornett, R; Henderson, GN; James, MO; Shroads, AL; Stacpoole, PW | 1 |
| Bull, RJ; Gonzalez-Leon, A; Merdink, JL; Schultz, IR | 1 |
| Anders, MW; Cornejo, J; Lantum, HB; Pierce, RH | 1 |
| Ammini, CV; Cheung, J; Cornett, R; Fernandez-Canon, J; Grompe, M; Henderson, GN; James, MO; Shroads, AL; Stacpoole, PW | 1 |
| Dixit, V; Guo, X; Henderson, GN; James, MO; Liu, H; Shroads, AL; Stacpoole, PW | 1 |
| Finegold, M; Jorquera, R; Langlois, C; Shroads, AL; Stacpoole, PW; Tanguay, RM | 1 |
| Henderson, GN; Jia, M; Liu, H; Stacpoole, PW; Zolodz, MD | 1 |
| Bullock, JR; Coats, BS; Gong, Y; Johnson, JA; Kurtz, TL; Langaee, T; Ostrov, DA; Shroads, AL; Stacpoole, PW; Wagner, DA; Weithorn, D | 1 |
| Abdelmalak, MM; Daigle, AD; James, MO; Maisenbacher, HW; Mincey, BD; Samper, IS; Shroads, AL; Stacpoole, PW; Zhong, G | 1 |
| Coats, BS; Langaee, T; McDonough, CW; Shroads, AL; Stacpoole, PW | 1 |
| Coats, BS; Langaee, T; Shroads, AL; Shuster, JJ; Stacpoole, PW | 1 |
| Amoroso, R; Arduini, A; Cama, A; Cataldi, A; De Lellis, L; di Giacomo, V; Florio, R; Gallorini, M; Mariani-Costantini, R; Natale, A; Perconti, S; Sanna, M; Verginelli, F; Veschi, S | 1 |
| Stacpoole, PW | 1 |
1 review(s) available for tyrosine and dichloroacetic acid
| Article | Year |
|---|---|
Clinical physiology and pharmacology of GSTZ1/MAAI.
Topics: Animals; Cytoplasm; Dichloroacetic Acid; Glutathione Transferase; Humans; Tyrosine | 2023 |
2 trial(s) available for tyrosine and dichloroacetic acid
| Article | Year |
|---|---|
Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Topics: Acetone; Adolescent; Adult; Aminolevulinic Acid; Child; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Female; Genetic Diseases, Inborn; Glutathione Transferase; Haplotypes; Humans; Infant; Kinetics; Male; Maleates; Mitochondrial Diseases; Polymorphism, Single Nucleotide; Tyrosine; Young Adult | 2015 |
Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
Topics: Acetone; Adult; Biomarkers; Chloral Hydrate; cis-trans-Isomerases; Dichloroacetic Acid; Female; Glutathione Transferase; Healthy Volunteers; Humans; Hypnotics and Sedatives; Male; Maleates; Tyrosine; Young Adult | 2015 |
10 other study(ies) available for tyrosine and dichloroacetic acid
| Article | Year |
|---|---|
Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.
Topics: Animals; Biotransformation; Cytosol; Dichloroacetic Acid; Feedback; Glutathione Transferase; Glyoxylates; Humans; Isoenzymes; Kinetics; Liver; Maleates; Rats; Tyrosine | 1999 |
Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.
Topics: Administration, Oral; Age Factors; Animals; Body Weight; Circadian Rhythm; cis-trans-Isomerases; Cytosol; Dichloroacetic Acid; Dose-Response Relationship, Drug; Drinking; Fresh Water; Glutathione Transferase; Injections, Intravenous; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Time Factors; Tyrosine | 2002 |
Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
Topics: Animals; Cell Line; Cell Survival; Chromatography, Liquid; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Kinetics; Liver; Male; Maleates; Mice; Mice, Transgenic; Porphobilinogen Synthase; Rats; Rats, Inbred F344; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.
Topics: Animals; Biotransformation; cis-trans-Isomerases; Cytosol; Dichloroacetic Acid; Inactivation, Metabolic; Liver; Male; Maleates; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tyrosine | 2003 |
Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Topics: Acetone; Administration, Oral; Aging; Animals; Blotting, Western; Body Weight; Dichloroacetic Acid; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Glutathione Transferase; Humans; Liver; Male; Maleates; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.
Topics: Animals; Cyclohexanones; Dichloroacetic Acid; Female; Glutathione; Glutathione Disulfide; Hydrolases; Kidney; Liver; Male; Mice; Nitrobenzoates; Oxidative Stress; Tyrosine; Tyrosinemias; Weight Loss | 2006 |
A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.
Topics: Acetone; Animals; Blotting, Western; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Heptanoates; Humans; Liver; Male; Maleates; Rats; Sensitivity and Specificity; Tyrosine | 2006 |
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Topics: Acetone; Adult; Amino Acid Substitution; Dichloroacetic Acid; Environmental Pollutants; Enzyme Stability; Female; Florida; Genetic Association Studies; Glutathione Transferase; Half-Life; Humans; Male; Maleates; Middle Aged; Models, Molecular; Mutation; Polymorphism, Single Nucleotide; Protein Conformation; Tyrosine; Young Adult | 2012 |
Pharmacokinetics of oral dichloroacetate in dogs.
Topics: Acetone; Analysis of Variance; Animals; Area Under Curve; Blotting, Western; cis-trans-Isomerases; Dichloroacetic Acid; Dogs; Glutathione Transferase; Half-Life; Injections, Intravenous; Male; Maleates; Tyrosine | 2013 |
Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Humans; Metformin; Oxazoles; Paraganglioma; Tyrosine | 2018 |