tyrosine has been researched along with deoxyglucose in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (13.95) | 18.7374 |
| 1990's | 35 (40.70) | 18.2507 |
| 2000's | 35 (40.70) | 29.6817 |
| 2010's | 3 (3.49) | 24.3611 |
| 2020's | 1 (1.16) | 2.80 |
| Authors | Studies |
|---|---|
| Roth, RA; Zhang, B | 1 |
| Akanuma, Y; Ando, A; Kaburagi, Y; Koshio, O; Momomura, K; Sakura, H; Tamori, Y; Tobe, K; Yamamoto-Honda, R; Yazaki, Y | 1 |
| Corvera, S; Jaspers, S; Pasceri, M | 1 |
| Hardy, RW; Henriksen, EJ; Holloszy, JO; Ladenson, JH; McDonald, JM | 1 |
| Daemen, BJ; Elsinga, PH; Konings, AW; Paans, AM; Vaalburg, W; Wieringa, AR | 1 |
| Coenen, HH; Heiss, WD; Herholz, K; Kling, P; Rudolf, J; Stöcklin, G; Wienhard, K | 1 |
| Daemen, BJ; Doorenbos, H; Elsinga, PH; Paans, AM; Vaalburg, W; Zwertbroek, R | 1 |
| Daemen, BJ; Elsinga, PH; Konings, AW; Lemstra, W; Paans, AM; Vaalburg, W | 1 |
| Olefsky, JM; Takata, Y; Webster, NJ | 1 |
| Capeau, J; Caron, M; Cherqui, G; Clauser, E; Melin, B; Picard, J; Reynet, C; Wicek, D | 1 |
| Go, KG; Kamman, RL; Korf, J; Paans, AM; Prenen, GH; Vaalburg, W | 1 |
| Klarlund, JK | 1 |
| Libby, J; Martinez, R; Weber, MJ | 1 |
| Bernier, M; Laird, DM; Lane, MD | 1 |
| Flier, JS; Matsouka, PT | 1 |
| Hamano, S; Morita, K; Oka, M; Teraoka, K | 1 |
| Alengrin, F; Ballotti, R; Honegger, AM; Obberghen, EV; Schlessinger, J; Scimeca, JC; Ullrich, A | 1 |
| Elsinga, PH; Go, KG; Kamman, RL; Molenaar, WM; Paans, AM; Prenen, GH; Sebens, JB; Vaalburg, W; Zijlstra, S; Zuiderveen, F | 1 |
| Auzan, C; Clauser, E; Contreres, JO; Debant, A; Filloux, C; Ponzio, G; Rossi, B | 1 |
| Clauser, E; Edery, M; Ellis, L; Morgan, DO; Roth, RA; Rutter, WJ | 1 |
| Berhanu, P; Jochen, AL | 1 |
| Boches, FS; Goldberg, AL | 1 |
| Baba, A; Cooper, JR | 1 |
| Ciaraldi, TP; Khoo, HE; Lim, KL; Ng, FH; Tan, CH; Wong, EH | 1 |
| Chang, JS; Iwashita, S; Kobayashi, M; Maruta, H; Wang, DZ | 1 |
| Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL; Paans, AM; Pruim, J; Vaalburg, W | 1 |
| Faria, TN; Kato, H; LeRoith, D; Roberts, CT; Stannard, B | 1 |
| Faria, TN; Kato, H; LeRoith, D; Levy-Toledano, R; Roberts, CT; Stannard, B; Taylor, SI | 1 |
| Blakesley, VA; Kato, H; LeRoith, D; Roberts, CT | 1 |
| Becker, S; Palm, D; Schinzel, R | 1 |
| Clark, AE; Hashiramoto, M; Holman, GD; Kasuga, M; Mori, H; Muraoka, A; Tamori, Y; Yang, J | 1 |
| Akanuma, Y; Kaburagi, Y; Kadowaki, T; Koshio, O; Momomura, K; Mori, Y; Shibasaki, Y; Tamori, Y; Tobe, K; Yamamoto-Honda, R | 1 |
| Gabbe, SG; Hooper, WC; Kniss, DA; Landon, MB; Su, HC; Zimmerman, PD | 1 |
| Cormont, M; Grémeaux, T; Le Marchand-Brustel, Y; Tanti, JF; Van Obberghen, E | 1 |
| Akanuma, Y; Kaburagi, Y; Kadowaki, T; Momomura, K; Sakura, H; Tamori, Y; Tobe, K; Yamamoto-Honda, R; Yazaki, Y | 1 |
| Kielar, D; Minokoshi, Y; Shimazu, T; Shimizu, Y | 1 |
| Hoekstra, HJ; Kole, AC; Nieweg, OE; Paans, AM; Plukker, JT; Pruim, J; Schraffordt Koops, H; Vaalburg, W | 1 |
| Minokoshi, Y; Shimazu, T; Shimizu, Y; Tanishita, T | 1 |
| Aitken, RJ; Harkiss, D; Irvine, DS; Knox, W; Paterson, M | 1 |
| Love, DC; Mentink Kane, M; Mosser, DM | 1 |
| Bala, TS; Raghunath, M | 1 |
| Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L | 1 |
| Nigam, SK; Tsukamoto, T | 1 |
| Barucci, N; Bell, K; Cline, GW; Goodyear, LJ; Griffin, ME; Kraegen, EW; Lee, D; Marcucci, MJ; Shulman, GI; White, MF | 1 |
| Peerschke, EI | 1 |
| Dufresne, SD; Goodyear, LJ; Higaki, Y; Hirshman, MF; Kahn, CR; Michael, MD; Wojtaszewski, JF | 1 |
| Bou-Hanna, C; Jarry, A; Laboisse, CL; Le Goffe, C; Vallette, G | 1 |
| Choi, WS; Heart, E; Sung, CK | 1 |
| Cohen, PT; Frevert, EU; Hansen, L; Kahn, BB; Pedersen, O; Rasmussen, SK | 1 |
| Fantus, IG; Goldstein, BJ; Lai, R; Le-Tien, H; Shin, P; Tang, S | 1 |
| Anai, M; Ando, K; Asano, T; Chiba, Y; Fujishiro, M; Fujita, T; Fukushima, Y; Inukai, K; Kikuchi, M; Ogihara, T; Onishi, Y; Ono, H; Sakoda, H; Sekine, N; Shojima, N | 1 |
| Hiroki, A; Suzuki, T; Takei, I; Umezawa, K; Watanabe, T; Yamashita, T | 1 |
| Huang, J; Imamura, T; Ishibashi , KI; Olefsky, JM; Sharma, PM; Ugi, S | 1 |
| Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Takano, A; Uno, T; Usui, I | 1 |
| Haruta, T; Ishibashi, O; Iwata, M; Kawahara, J; Kobayashi, M; Sasaoka, T; Takano, A; Ueno, E; Uno, T; Usui, I | 1 |
| Barf, T; Bleasdale, JE; Larsen, SD; Liljebris, C; May, PD; O'Sullivan, TJ; Ogg, D; Palazuk, BJ; Schostarez, HJ; Stevens, FC | 1 |
| Aschenbach, WG; Dow, M; Goodyear, LJ; Hirshman, MF; Howlett, KF; Sakamoto, K; White, MF | 1 |
| Buck, A; Gottschalk, J; Kaim, AH; Kurrer, MO; Schweitzer, A; von Schulthess, GK; Weber, B; Westera, G | 1 |
| Abe, M; Anai, M; Ando, K; Asano, T; Fujishiro, M; Fujita, T; Fukushima, Y; Kikuchi, M; Ogihara, T; Onishi, Y; Ono, H; Sakoda, H; Shojima, N | 1 |
| Gonzalez, T; Grémeaux, T; Gual, P; Kanzaki, M; Le Marchand-Brustel, Y; Pessin, JE; Shigematsu, S; Tanti, JF | 1 |
| Dey, CS; Kumar, N | 3 |
| Ishizawa, M; Ishizuka, T; Kajita, K; Kanoh, Y; Kawai, Y; Miura, A; Natsume, Y; Sakuma, H; Yamamoto, Y; Yasuda, K | 1 |
| Bleasdale, JE; Bodnar, PM; Larsen, SD; Lindberg, TJ; O'Sullivan, TJ; Palazuk, BJ; Schostarez, HJ; Stevens, FC | 1 |
| Lagerquist Hägglund, C; Lundahl, P | 1 |
| Anai, M; Asano, T; Fujishiro, M; Fukushima, Y; Honda, M; Inukai, K; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Onishi, Y; Ono, H; Sakoda, H; Shojima, N | 1 |
| Furuhashi, M; Higashiura, K; Hyakukoku, M; Murakami, H; Shimamoto, K; Ura, N; Yamaguchi, K | 1 |
| Bassel-Duby, R; Olson, EN; Ryder, JW; Zierath, JR | 1 |
| Bazuine, M; Gomes de Mesquita, DS; Maassen, JA; Ouwens, DM | 1 |
| Aitken, RJ; Baker, MA; Ecroyd, H; Hetherington, L; Roman, SD | 1 |
| Barth, T; Barthová, J; Jirácek, J; Záková, L; Zórad, S | 1 |
| Cline, GW; Davies, PJ; Leibowitz, MD; Shen, Q; Shulman, GI | 1 |
| Befroy, D; Bilz, S; Elder, BD; Liu, ZX; Qu, X; Romanelli, AJ; Samuel, VT; Shulman, GI | 1 |
| Babendreier, E; Chauhan, D; Chu, SC; Gramlich, JL; Griffin, JD; Kim, JH; Podar, K; Pride, YB; Salgia, R; Sattler, M | 1 |
| Dey, CS; Miranda, ER | 1 |
| Baumgartner, F; Brodbeck, K; Häring, HU; Hennige, AM; Lehmann, R; Schaüble, M; Schleicher, ED; Weigert, C | 1 |
| Coenen, HH; Hamacher, K; Klauth, P; Langen, KJ; Oros-Peusquens, AM; Pauleit, D; Salber, D; Shah, NJ; Stoffels, G | 1 |
| Drozdov, I; Gustafsson, BI; Hauso, O; Kidd, M; Modlin, IM; Pfragner, R | 1 |
| Bachelard, H; Badeau, M; Bourgoin, F; Larivière, R; Mélançon, S; Nadeau, A; Pitre, M | 1 |
| Gotoh, H; Nagai, K; Okumura, A; Okumura, N | 1 |
| Adochio, R; Draznin, B; Kim, T; Wayne Leitner, J | 1 |
| Kim, SJ; Yu, SM | 1 |
| Abu Aboud, O; Weiss, RH; Wettersten, HI | 1 |
| Brulhart-Meynet, MC; James, RW; Lerch, R; Montessuit, C; Papageorgiou, I; Viglino, C | 1 |
| MacPherson, REK; Shamshoum, H; Tsiani, E; Vlavcheski, F | 1 |
86 other study(ies) available for tyrosine and deoxyglucose
| Article | Year |
|---|---|
The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Base Sequence; Blotting, Northern; Blotting, Western; Cells, Cultured; CHO Cells; Cricetinae; Deoxyglucose; DNA; GTPase-Activating Proteins; Insulin; Molecular Sequence Data; Phosphorylation; Phosphotransferases; Polymerase Chain Reaction; Precipitin Tests; Proteins; Receptor, Insulin; Signal Transduction; Substrate Specificity; Thymidine; Tissue Distribution; Tyrosine | 1992 |
Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.
Topics: Animals; Antigen-Antibody Complex; Base Sequence; CHO Cells; Cricetinae; Deoxyglucose; DNA; Endocytosis; Enzyme Activation; Growth Substances; Immunoblotting; Insulin; Lectins; Molecular Sequence Data; Mutation; Phenylalanine; Phosphorylation; Precipitin Tests; Protein Kinases; Receptor, Insulin; Solubility; Thymidine; Transfection; Tyrosine | 1992 |
Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Cell Membrane; Deoxyglucose; Dose-Response Relationship, Drug; Ethers, Cyclic; In Vitro Techniques; Insulin; Insulin Antagonists; Male; Methylglucosides; Monosaccharide Transport Proteins; Okadaic Acid; Phosphotyrosine; Rats; Tyrosine | 1991 |
Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter (GLUT4).
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Cells, Cultured; Deoxyglucose; Glucose; Insulin; Kinetics; Macromolecular Substances; Male; Methylglucosides; Monosaccharide Transport Proteins; Muscles; Palmitic Acid; Palmitic Acids; Phosphotyrosine; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine | 1991 |
Radiation-induced inhibition of tumor growth as monitored by PET using L-[1-11C]tyrosine and fluorine-18-fluorodeoxyglucose.
Topics: Animals; Carbon Radioisotopes; Combined Modality Therapy; Deoxyglucose; Female; Fluorodeoxyglucose F18; Hyperthermia, Induced; Radiotherapy Dosage; Rats; Rhabdomyosarcoma; Tomography, Emission-Computed; Tyrosine | 1992 |
Increased amino acid transport into brain tumors measured by PET of L-(2-18F)fluorotyrosine.
Topics: Adult; Aged; Blood-Brain Barrier; Brain Neoplasms; Deoxyglucose; Edetic Acid; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Tomography, Emission-Computed; Tyrosine | 1991 |
PET studies with L-[1-11C]tyrosine, L-[methyl-11C]methionine and 18F-fluorodeoxyglucose in prolactinomas in relation to bromocryptine treatment.
Topics: Adult; Bromocriptine; Carbon Radioisotopes; Deoxyglucose; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Male; Methionine; Middle Aged; Pituitary Neoplasms; Prolactinoma; Tomography, Emission-Computed; Tyrosine | 1991 |
Suitability of rodent tumor models for experimental PET with L-[1-11C]tyrosine and 2-[18F]fluoro-2-deoxy-D-glucose.
Topics: Animals; Carbon Isotopes; Carcinoma 256, Walker; Deoxyglucose; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Lymphoma, Non-Hodgkin; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Proteins; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Tyrosine | 1991 |
Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.
Topics: Animals; Cell Line; Deoxyglucose; DNA; DNA Mutational Analysis; In Vitro Techniques; Insulin; Mitosis; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Signal Transduction; Structure-Activity Relationship; Tyrosine | 1991 |
Insulin receptor tyrosine residues 1162 and 1163 control insulin stimulation of myristoyl-diacylglycerol generation and subsequent activation of glucose transport.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Cell Line; Deoxyglucose; Diglycerides; Insulin; Kinetics; Mutagenesis, Site-Directed; Phorbol Esters; Phosphorylation; Protein Kinase C; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1990 |
Positron emission tomography study of 11C-acetoacetate uptake in a freezing lesion in cat brain, as correlated with 11C-tyrosine and 18F-fluorodeoxyglucose uptake, and with proton magnetic resonance imaging.
Topics: Acetoacetates; Animals; Blood-Brain Barrier; Brain Chemistry; Brain Edema; Brain Injuries; Cats; Cold Temperature; Deoxy Sugars; Deoxyglucose; Fluorodeoxyglucose F18; Magnetic Resonance Imaging; Tomography, Emission-Computed; Tyrosine | 1990 |
Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins.
Topics: Animals; Cell Count; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Deoxyglucose; Kinetics; Mice; Moloney murine sarcoma virus; Phosphatidylinositols; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphotyrosine; Rats; Tyrosine; Vanadates; Vanadium; Zinc | 1985 |
Tyrosine phosphorylation in cells treated with transforming growth factor-beta.
Topics: Animals; Cell Line; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Peptides; Phosphorylation; Phosphotyrosine; Rats; Transforming Growth Factors; Tyrosine | 1986 |
Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action.
Topics: Adenosine Triphosphate; Adipose Tissue; Arsenicals; Cell Line; Deoxyglucose; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Insulin; Kinetics; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Trypsin; Tyrosine; Vanadates | 1988 |
Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Line, Transformed; Deoxyglucose; Fibroblasts; Gene Expression Regulation; Mice; Monosaccharide Transport Proteins; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Tyrosine | 1989 |
Effects of cytoskeleton-disrupting agents on tyrosine transport into cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Biological Transport; Cattle; Cells, Cultured; Chromaffin System; Cytochalasin B; Cytoskeleton; Deoxyglucose; Tyrosine; Vinblastine | 1989 |
Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants.
Topics: Aminoisobutyric Acids; Animals; Biological Transport; Deoxy Sugars; Deoxyglucose; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Protein-Tyrosine Kinases; Structure-Activity Relationship; Transfection; Tyrosine | 1989 |
Positron emission tomographical studies of 1-11C-acetoacetate, 2-18F-fluoro-deoxy-D-glucose, and L-1-11C-tyrosine uptake by cat brain with an experimental lesion.
Topics: Acetoacetates; Animals; Blood Glucose; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Brain Ischemia; Carbon Radioisotopes; Cats; Cerebrovascular Circulation; Deoxyglucose; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Freezing; Nerve Tissue Proteins; Parietal Lobe; Tomography, Emission-Computed; Tyrosine | 1989 |
Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.
Topics: Animals; Cell Line; Cricetinae; Deoxyglucose; DNA Replication; Protein Kinases; Receptor, Insulin; Ribosomal Protein S6 Kinases; Solubility; Tyrosine | 1988 |
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose.
Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Cricetulus; Deoxy Sugars; Deoxyglucose; DNA; Female; Gene Expression Regulation; Humans; Insulin; Ovary; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Tyrosine | 1986 |
Insulin-stimulated glucose transport and insulin internalization share a common postbinding step in adipocytes.
Topics: Adenosine Triphosphate; Adipose Tissue; Animals; Chymotrypsin; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Antagonists; Male; Rats; Rats, Inbred Strains; Tyrosine | 1987 |
Role for the adenosine triphosphate-dependent proteolytic pathway in reticulocyte maturation.
Topics: Adenosine Triphosphate; Animals; Blood Proteins; Cell Differentiation; Cyclophosphamide; Deoxyglucose; Dinitrophenols; Lysosomes; Rabbits; Reticulocytes; Tyrosine | 1982 |
The action of black widow spider venom on cholinergic mechanisms in synaptosomes.
Topics: Acetylcholine; Animals; Arthropod Venoms; Biological Transport; Black Widow Spider; Calcium; Cerebral Cortex; Choline; Deoxyglucose; Kinetics; L-Lactate Dehydrogenase; Male; Membrane Potentials; Norepinephrine; Rats; Spider Venoms; Spiders; Synaptosomes; Tyrosine; Veratridine | 1980 |
Rat fibroblast cells overexpressing kinase-inactive human insulin receptors are insulin responsive: influence of growth conditions.
Topics: Animals; Biological Transport; Cell Line; Deoxyglucose; DNA; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Glucose; Glycogen Synthase; Humans; Insulin; Insulin-Like Growth Factor I; Phosphotyrosine; Rats; Receptor, Insulin; Tyrosine | 1995 |
Two regions with differential growth-modulating activity in the N-terminal domain of ras GTPase-activating protein (p120GAP) src homology and Gly-Ala-Pro-rich regions.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Deoxyglucose; GTPase-Activating Proteins; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Proteins; ras GTPase-Activating Proteins; Rats; Sequence Homology, Amino Acid; Signal Transduction; src Homology Domains; Transfection; Tyrosine | 1995 |
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Phosphorylcholine; Supratentorial Neoplasms; Tomography, Emission-Computed; Tyrosine | 1995 |
Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).
Topics: 3T3 Cells; Animals; Base Sequence; Cell Cycle; Deoxyglucose; Enzyme Activation; Gene Expression; Immunologic Techniques; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Ornithine Decarboxylase; Phosphatidylinositol 3-Kinases; Phosphotransferases; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Somatomedin; RNA, Messenger; Signal Transduction; Tyrosine | 1993 |
Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells.
Topics: 3T3 Cells; Animals; CHO Cells; Cricetinae; Deoxyglucose; DNA; Enzyme Activation; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases; Phosphotyrosine; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Transfection; Tyrosine | 1993 |
Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Conserved Sequence; Deoxyglucose; DNA Primers; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Somatomedin; Signal Transduction; Thymidine; Tryptophan; Tyrosine; Wheat Germ Agglutinins | 1995 |
Dissecting differential binding in the forward and reverse reaction of Escherichia coli maltodextrin phosphorylase using 2-deoxyglucosyl substrates.
Topics: Amino Acid Sequence; Binding Sites; Carbohydrate Conformation; Carbohydrate Sequence; Deoxyglucose; Escherichia coli; Glucans; Glucosyltransferases; Glutamates; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligosaccharides; Polysaccharides, Bacterial; Recombinant Proteins; Substrate Specificity; Tyrosine | 1994 |
Substitution of tyrosine 293 of GLUT1 locks the transporter into an outward facing conformation.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Azides; Base Sequence; Blotting, Western; Cell Membrane; CHO Cells; Cricetinae; Cytochalasin B; Deoxyglucose; Disaccharides; DNA Primers; Electrophoresis, Polyacrylamide Gel; Glucose Transporter Type 1; Glycosides; Humans; Isoleucine; Kinetics; Molecular Sequence Data; Molecular Weight; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Propylamines; Protein Conformation; Recombinant Proteins; Transfection; Tyrosine | 1994 |
Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin.
Topics: Animals; Cell-Free System; CHO Cells; Cricetinae; Deoxyglucose; Humans; Insulin; Kinetics; Lectins; Mutation; Phosphorylation; Precipitin Tests; Receptor, Insulin; Solubility; Swine; Transfection; Tyrosine | 1993 |
Expression of functional insulin-like growth factor-I receptors by human amnion cells.
Topics: Amnion; Binding, Competitive; Blotting, Northern; Cell Line; Cells, Cultured; Cytochalasin B; Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Humans; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Phosphorylation; Radioligand Assay; Receptor, IGF Type 1; RNA, Messenger; Tyrosine | 1993 |
Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes.
Topics: Adipose Tissue; Animals; Biological Transport; Deoxyglucose; Ethers, Cyclic; Insulin; Insulin Antagonists; Insulin-Like Growth Factor II; Male; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 2; Tyrosine | 1993 |
Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Membrane; CHO Cells; Cricetinae; Deoxyglucose; DNA; Enzyme Activation; Glycogen Synthase; Humans; Insulin; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Phosphotransferases; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Solubility; Tyrosine | 1993 |
Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Biological Transport; Cells, Cultured; Cyclic AMP; Deoxyglucose; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Kinetics; Monosaccharide Transport Proteins; Muscle Proteins; Norepinephrine; Phosphorylation; Rats; Subcellular Fractions; Tyrosine | 1996 |
Standardized uptake value and quantification of metabolism for breast cancer imaging with FDG and L-[1-11C]tyrosine PET.
Topics: Blood Glucose; Breast; Breast Neoplasms; Carbon Radioisotopes; Carcinoma, Ductal, Breast; Deoxyglucose; Female; Fibrocystic Breast Disease; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Tomography, Emission-Computed; Tyrosine | 1997 |
The beta3-adrenergic agonist BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin.
Topics: Adrenergic beta-Agonists; Androstadienes; Animals; Biological Transport; Cells, Cultured; Deoxyglucose; Dose-Response Relationship, Drug; Ethanolamines; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Kinetics; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Proteins; Rats; Subcellular Fractions; Tyrosine; Wortmannin | 1997 |
A novel signal transduction cascade in capacitating human spermatozoa characterised by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation.
Topics: Catalase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Enzyme Inhibitors; Humans; Male; Onium Compounds; Oxidation-Reduction; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sperm Capacitation; Tyrosine | 1998 |
Leishmania amazonensis: the phagocytosis of amastigotes by macrophages.
Topics: Actins; Animals; Antimetabolites; Blotting, Western; Cytochalasin B; Cytoskeletal Proteins; Deoxyglucose; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Genistein; Humans; Leishmania mexicana; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Paxillin; Phagocytosis; Phosphoproteins; Phosphorylation; Talin; Tyrosine | 1998 |
Diverse effects of mild and potent goitrogens on blood-brain barrier nutrient transport.
Topics: Animals; Antithyroid Agents; Blood-Brain Barrier; Deoxyglucose; Female; Hypothyroidism; Leucine; Methimazole; Pregnancy; Rats; Rats, Wistar; Sucrose; Thiocyanates; Tyrosine | 1998 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Antimetabolites; Antimycin A; Carrier Proteins; Cell Line; Cytoskeleton; Deoxyglucose; Detergents; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Genistein; Kidney Tubules, Distal; Membrane Proteins; Occludin; Octoxynol; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Solubility; Tight Junctions; Tyrosine; Zonula Occludens Proteins; Zonula Occludens-1 Protein; Zonula Occludens-2 Protein | 1999 |
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Topics: Animals; Deoxyglucose; Enzyme Activation; Fatty Acids, Nonesterified; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine; Zinc Fingers | 1999 |
Maintenance of GPIIb-IIIa avidity supporting "irreversible" fibrinogen binding is energy-dependent.
Topics: Adenosine Diphosphate; Androstadienes; Anti-Bacterial Agents; Antibodies, Monoclonal; Antimetabolites; Antimycin A; Benzoquinones; Blood Platelets; Deoxyglucose; Dimethyl Sulfoxide; Energy Metabolism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excipients; Fibrinogen; Humans; Lactams, Macrocyclic; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Polylysine; Protein Binding; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Tyrosine; Wortmannin | 1999 |
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.
Topics: Animals; Biological Transport; Deoxyglucose; Glucose; Glucose Tolerance Test; Glycogen; Glycogen Synthase; Insulin; Insulin Receptor Substrate Proteins; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Physical Conditioning, Animal; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Signal Transduction; Time Factors; Tyrosine | 1999 |
The in vitro manipulation of carbohydrate metabolism: a new strategy for deciphering the cellular defence mechanisms against nitric oxide attack.
Topics: Adenosine Triphosphate; Carbohydrate Metabolism; Cell Survival; Culture Media; Deoxyglucose; Epithelial Cells; Galactose; Glucose; Glutathione; HT29 Cells; Humans; Lactic Acid; Nitric Oxide; Nitroso Compounds; Oligomycins; Pyruvic Acid; S-Nitrosoglutathione; Tyrosine | 1999 |
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Deoxyglucose; Dose-Response Relationship, Drug; Glucosamine; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tyrosine | 2000 |
Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes.
Topics: Adenoviridae; Animals; Aspartic Acid; Biological Transport; Cell Line; CHO Cells; Cricetinae; Deoxyglucose; Genetic Variation; Genetic Vectors; Glycogen; Green Fluorescent Proteins; Humans; Luminescent Proteins; Muscle, Skeletal; Phosphoprotein Phosphatases; Polymorphism, Genetic; Protein Phosphatase 1; Recombinant Fusion Proteins; Transfection; Tyrosine | 2000 |
Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes.
Topics: Adipocytes; Animals; Deoxyglucose; Hyperglycemia; Immunoblotting; Insulin Resistance; Male; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Tyrosine | 2001 |
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Deoxyglucose; Diet, Sodium-Restricted; Enzyme Activation; Glucose Clamp Technique; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Thiazoles; Thiazolidinediones; Tyrosine | 2001 |
Potentiation of insulin-related signal transduction by a novel protein-tyrosine phosphatase inhibitor, Et-3,4-dephostatin, on cultured 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Catecholamines; Chromones; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Hypoglycemic Agents; Insulin; Mice; Morpholines; Nitroso Compounds; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine | 2001 |
Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Biological Transport; Deoxyglucose; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Glucose Transporter Type 4; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Intramolecular Transferases; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Receptor, Endothelin A; Signal Transduction; Tyrosine; Ubiquitin-Protein Ligases | 2001 |
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cytosol; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Glucose; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tyrosine | 2001 |
Potential role of Gab1 and phospholipase C-gamma in osmotic shock-induced glucose uptake in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Cytochalasin D; Deoxyglucose; Glucose; Immunoblotting; Isoenzymes; Mice; Nucleic Acid Synthesis Inhibitors; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Precipitin Tests; Type C Phospholipases; Tyrosine | 2001 |
Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.
Topics: Cell Line; Crystallography, X-Ray; Deoxyglucose; Dipeptides; Enzyme Inhibitors; Hydrogen Bonding; Insulin; Models, Molecular; Molecular Mimicry; Molecular Weight; Peptides; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tyrosine | 2002 |
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice.
Topics: Animals; Blood Glucose; Deoxyglucose; Glycogen; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Motor Activity; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Signal Transduction; Tyrosine | 2002 |
(18)F-FDG and (18)F-FET uptake in experimental soft tissue infection.
Topics: Abscess; Animals; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Fluorodeoxyglucose F18; Leg; Leukocytes; Myositis; Radionuclide Imaging; Radiopharmaceuticals; Rats; Reference Values; Staphylococcal Infections; Tyrosine | 2002 |
High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.
Topics: Adipose Tissue; Animals; Deoxyglucose; Enzyme Activation; Humans; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Potassium, Dietary; Rats; Rats, Inbred Dahl; Signal Transduction; Sodium Chloride, Dietary; Species Specificity; Tyrosine | 2002 |
A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Biological Transport; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Deoxyglucose; Depsipeptides; Electrophoresis, Polyacrylamide Gel; Glucose; Glucose Transporter Type 4; Isoenzymes; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Osmosis; Osmotic Pressure; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Precipitin Tests; Protein Binding; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; rho GTP-Binding Proteins; Signal Transduction; Thiazoles; Thiazolidines; Time Factors; Type C Phospholipases; Tyrosine | 2002 |
Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells.
Topics: Animals; Cells, Cultured; Deoxyglucose; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Receptor, Insulin; Signal Transduction; Tyrosine | 2002 |
Gliclazide increases insulin receptor tyrosine phosphorylation but not p38 phosphorylation in insulin-resistant skeletal muscle cells.
Topics: Animals; Cell Line; Deoxyglucose; Enzyme Inhibitors; Gliclazide; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Receptor, Insulin; Signal Transduction; Tyrosine | 2002 |
Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells.
Topics: Animals; Biological Transport; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Deoxyglucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Muscle, Skeletal; Myoblasts; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pioglitazone; Receptor, Insulin; Rosiglitazone; Thiazoles; Thiazolidinediones; Tyrosine | 2003 |
Inhibitory effect of ceramide on insulin-induced protein kinase Czeta translocation in rat adipocytes.
Topics: Adipocytes; Animals; Blotting, Western; Ceramides; Deoxyglucose; Glucose; Hypoglycemic Agents; Insulin; Male; Membranes; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Transport; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Tyrosine | 2003 |
Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity.
Topics: Animals; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Humans; Insulin; Molecular Mimicry; Muscle, Skeletal; Phenylalanine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Salicylates; src Homology Domains; Tyrosine | 2003 |
Centrifugal and chromatographic analyses of tryptophan and tyrosine uptake by red blood cells and GLUT1 proteoliposomes with permeability estimates and observations on dihydrocytochalasin B.
Topics: Biological Transport; Cell Membrane Permeability; Cells, Cultured; Centrifugation; Chromatography, Gel; Cytochalasin B; Deoxyglucose; Erythrocytes; Glucose Transporter Type 1; Humans; Monosaccharide Transport Proteins; Permeability; Proteolipids; Tryptophan; Tyrosine; Ultrafiltration | 2003 |
Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation.
Topics: Adipose Tissue; Alcohol Drinking; Animals; Deoxyglucose; Enzyme Activation; Ethanol; Glucose Clamp Technique; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Tyrosine | 2003 |
The effect of tumor necrosis factor-alpha on tissue specificity and selectivity to insulin signaling.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Arteriosclerosis; Cells, Cultured; Deoxyglucose; Insulin; Insulin Receptor Substrate Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor, Insulin; Sensitivity and Specificity; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways.
Topics: Animals; beta-Alanine; Calcineurin; Deoxyglucose; Dietary Fats; Enzyme Activation; Gene Expression; Glucose Intolerance; Glucose Transporter Type 4; Glycogen; Insulin; Insulin Receptor Substrate Proteins; Mice; Mice, Transgenic; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Oleic Acid; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction; Tyrosine | 2003 |
Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.
Topics: 3T3 Cells; Adipocytes; Animals; Arsenites; Biological Transport; Caveolin 1; Caveolins; Cells, Cultured; Deoxyglucose; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Imidazoles; Insulin; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; Oncogene Protein v-cbl; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Pyridines; Receptor, Insulin; Retroviridae Proteins, Oncogenic; Signal Transduction; Tyrosine | 2003 |
Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation.
Topics: Acrosome; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Cyclic AMP; Deoxyglucose; Enzyme Inhibitors; Epididymis; Glucose; Humans; Hydrogen-Ion Concentration; Male; Mice; Mitochondria; Phosphorylation; Rotenone; Signal Transduction; Sperm Capacitation; Spermatozoa; Thapsigargin; Tyrosine; Uncoupling Agents | 2004 |
Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.
Topics: Amino Acid Substitution; Animals; Biological Transport; Deoxyglucose; Humans; Hydrogen Bonding; Insulin; Male; Methylation; Peptide Fragments; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Rats; Rats, Wistar; Receptor, Insulin; Recombinant Proteins; Swine; Tyrosine | 2004 |
Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Biological Transport; Blotting, Western; Body Weight; Cattle; Deoxyglucose; Diabetes Mellitus, Experimental; Glucose; Insulin; Insulin Resistance; Ligands; Ligases; Mice; Muscle, Skeletal; Muscles; Organic Chemicals; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors; Triglycerides; Tyrosine; Ubiquitin-Protein Ligases | 2004 |
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.
Topics: Animals; Blotting, Western; Cell Membrane; Cytosol; Deoxyglucose; Enzyme Activation; Fatty Acids; Fatty Liver; Glycogen; Glycogen Synthase; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Protein Kinase C-epsilon; Protein Transport; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Tyrosine | 2004 |
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Topics: Benzamides; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Deoxyglucose; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Jurkat Cells; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monosaccharide Transport Proteins; Phloretin; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinases; Pyrimidines; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Tyrosine; Up-Regulation | 2005 |
Effect of chromium and zinc on insulin signaling in skeletal muscle cells.
Topics: Animals; Cell Line; Chromium; Deoxyglucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Signal Transduction; Tyrosine; Zinc | 2004 |
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.
Topics: Animals; Blotting, Western; Cell Line; Deoxyglucose; Glucose; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Interleukin-6; Liver; Mice; Mice, Inbred C57BL; Models, Statistical; Muscle, Skeletal; Muscles; Phosphoproteins; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Serine; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Time Factors; Transfection; Tyrosine | 2006 |
Differential uptake of O-(2-18F-fluoroethyl)-L-tyrosine, L-3H-methionine, and 3H-deoxyglucose in brain abscesses.
Topics: Animals; Blood-Brain Barrier; Brain Abscess; Deoxyglucose; Fluorine Radioisotopes; Male; Methionine; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tritium; Tyrosine | 2007 |
Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants.
Topics: Amino Acid Transport System A; Bile Acids and Salts; Caffeine; Carcinoid Tumor; Cell Line, Tumor; Deoxycholic Acid; Deoxyglucose; Enterochromaffin Cells; Extracellular Signal-Regulated MAP Kinases; Glucose Transport Proteins, Facilitative; Glutamine; Humans; Intestinal Neoplasms; Intestine, Small; Organic Anion Transporters, Sodium-Dependent; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Receptors, Odorant; Serotonin; Sodium-Glucose Transporter 1; Somatostatin; Sucrose; Symporters; Tyrosine | 2008 |
Endothelial and vascular dysfunctions and insulin resistance in rats fed a high-fat, high-sucrose diet.
Topics: Animals; Blood Pressure; Blotting, Western; Body Weight; Deoxyglucose; Diet; Dietary Fats; Endothelin-1; Endothelium, Vascular; Fatty Acids, Nonesterified; Fluorescent Antibody Technique; Glucose Clamp Technique; Heart Rate; Insulin; Insulin Resistance; Male; Obesity; Organ Size; Rats; Rats, Sprague-Dawley; Sucrose; Triglycerides; Tyrosine; Vascular Diseases; Vascular Resistance | 2008 |
Localization of phospho-tyrosine489-beta-adducin immunoreactivity in the hypothalamic tanycytes and its involvement in energy homeostasis.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Calmodulin-Binding Proteins; Cerebral Ventricles; Cytoskeletal Proteins; Deoxyglucose; Dopamine and cAMP-Regulated Phosphoprotein 32; Eating; Energy Metabolism; Fasting; Homeostasis; Hypothalamus; Immunoblotting; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intraventricular; Male; Median Eminence; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Tyrosine | 2008 |
Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Deoxyglucose; Gene Knockdown Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mitochondrial Diseases; Mitogen-Activated Protein Kinase 8; Phosphatidylinositol 3-Kinases; Phosphorylation; Serine; Tyrosine | 2009 |
Protein phosphorylation on tyrosine restores expression and glycosylation of cyclooxygenase-2 by 2-deoxy-D-glucose-caused endoplasmic reticulum stress in rabbit articular chondrocyte.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cyclooxygenase 2; Deoxyglucose; Endoplasmic Reticulum Stress; Gene Expression Regulation, Enzymologic; Glycosylation; HSP70 Heat-Shock Proteins; Membrane Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rabbits; Transcription Factor CHOP; Tyrosine | 2012 |
Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells.
Topics: Apoptosis; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 4; Deoxyglucose; G1 Phase; Glucose; Glycolysis; Humans; Immunoblotting; Immunohistochemistry; Kidney Neoplasms; Oxazoles; PPAR alpha; Proto-Oncogene Proteins c-myc; Resting Phase, Cell Cycle; RNA Interference; Tyrosine | 2013 |
Impaired stimulation of glucose transport in cardiac myocytes exposed to very low-density lipoproteins.
Topics: AMP-Activated Protein Kinases; Animals; Biological Transport; Cells, Cultured; Cholesterol; Deoxyglucose; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; GTPase-Activating Proteins; Humans; Insulin; Lipoproteins, VLDL; Male; Mitochondria, Heart; Myocytes, Cardiac; Oligomycins; Oxidation-Reduction; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Stress, Physiological; Tyrosine; Uncoupling Agents | 2016 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models, Animal; Enzyme Activation; Glucose Transporter Type 4; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphorylation; Plant Extracts; Rats; Rosmarinus; Serine; TOR Serine-Threonine Kinases; Tyrosine | 2021 |