tyrosine has been researched along with cyclosporine in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 16 (47.06) | 29.6817 |
| 2010's | 5 (14.71) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Domenico, J; Franklin, RA; Gelfand, EW; Renz, H; Schwinzer, R | 1 |
| Cairns, J; Guy, GR; Philp, R; Qin, S; Tan, YH | 1 |
| Coles, JG; Diaz, RJ; Mills, GB; Parkinson, D; Radde, IC; Tsao, PW; Waddell, J; Wilson, GJ | 1 |
| Astashkin, EI; Bulargina, TV; Danilkovich, AV; Freze, KV; Kharitonenkov, AI; Khodorova, AB; Shevalier, AF; Surin, AM | 1 |
| Burger, PM; Goos, M; Nussbaum, G; Ockenfels, HM; Schultewolter, T | 1 |
| Gottschalk, AR; Joseph, LJ; Quintáns, J | 1 |
| Goos, M; Mertins, K; Nussbaum, G; Ockenfels, HM; Schultewolter, T; Wagner, SN | 1 |
| Armitage, IM; Caserta, C; Handschumacher, RE; Kakalis, LT; McCornack, MA | 1 |
| Bröker, BM; de Villartay, JP; Fleckenstein, B; Fleischer, B; Klauenberg, U; Kraft, MS; Le Deist, F; Meinl, E | 1 |
| Bondada, S; Muthukkumar, S; Muthusamy, N; Venkataraman, C | 1 |
| Ben-Bassat, H; Klein, BY; Rojansky, N; Stekelenburg, J | 1 |
| Hioki, K; Kameshita, I; Mohri, T; Suzuki, S; Takatani, S; Tokunaga, R | 1 |
| Goto, Y; Ishii, M; Kono, T; Sato, EF | 1 |
| Bothwell, A; Chae, WJ; Chang, EJ; Han, DJ; Han, JH; Lee, HK; Lee, SK; Morio, T; Shim, JH; Yang, JJ | 1 |
| Antonello, A; Calò, L; Davis, PA; Giacon, B; Huber, W; Pagnin, E; Piccin, A; Riegler, P; Semplicini, A | 1 |
| Colburn, MJ; Dong, Y; Fechner, J; Fernandez, LA; Hamawy, MM; Hu, H; Ishido, N; Kanmaz, T; Knechtle, SJ; Oberley, T; Schultz, J; Tae Kim, H; Torrealba, J; Tsuchida, M; Yagci, G | 1 |
| Chang, CH; Chang, GD; Che, D; Chen, ZJ; Liu, S; Vetter, M | 1 |
| Chan, F; Madhavan, R; Peng, HB; Wu, Z; Zhao, XT | 1 |
| Chen, M; Henderson, JD; Johnson, CP; Khanna, AK; Nilakantan, V; Pieper, GM; Roza, AM; Szabó, C; Zhou, J | 1 |
| Barnes, AD; Chen, M; Farivar, AS; Jagtap, P; MacKinnon-Patterson, BC; McCourtie, AS; Mulligan, MS; Salerno, CT; Szabó, C; Woolley, SM | 1 |
| Bai, J; Cederbaum, AI | 1 |
| Bauer, JA; Crouser, ED; Huff, JE; Joshi, MS; Julian, MW; Xia, Y | 1 |
| Ito, J; Kheirollah, A; Lu, R; Nagayasu, Y; Yokoyama, S | 1 |
| Alvarez-Barrientos, A; Fernández, AP; Lamas, S; León-Gómez, E; Navarro-Antolín, J; Redondo-Horcajo, M; Rodrigo, J; Zaragoza, C | 1 |
| Burke, AS; Hinson, JA; James, LP; Kurten, RC; Redeker, K | 1 |
| Hall, ED; Mbye, LH; Singh, IN; Springer, JE; Sullivan, PG | 1 |
| Aniya, Y; Hossain, QS; Lee, KK; Shimoji, M; Sunakawa, H | 1 |
| Cooley, BC; Ionova, IA; Khanna, AK; Migrino, RQ; Pieper, GM; Vásquez-Vivar, J; Whitsett, J | 1 |
| Agarwal, SK; Banerjee, KG; Dinda, AK; Guleria, S; Gupta, R; Jain, S; Sharma, A | 1 |
| Enríquez, JA; Lamas, S; Lourenço, CF; Martínez-Acedo, P; Martínez-Ruiz, A; Movilla, N; Quijano, C; Radi, R; Redondo-Horcajo, M; Rial, E; Rodríguez-Pascual, F; Romero, N; Vázquez, J | 1 |
| Ansari, IU; Fernandes, F; Striker, R | 1 |
| Burdmann, EA; Carlos, CP; Coimbra, TM; da Silva, CG; Luz, MA; Mendes, GE; Miquelin, AR; van Rooijen, N | 1 |
| Alves, SA; Burdmann, EA; Carlos, CP; Coimbra, TM; Luz, MA; Matimoto, RL; Mendes, GE; Oliveira, SM; Souza, RP | 1 |
| Creton, R; Tucker Edmister, S | 1 |
1 trial(s) available for tyrosine and cyclosporine
| Article | Year |
|---|---|
Oxidative stress and TGFbeta in kidney-transplanted patients with cyclosporin-induced hypertension. Effect of carvedilol and nifedipine.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Carbazoles; Carvedilol; Cyclosporine; Drug Evaluation; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypertension; Immunosuppressive Agents; Kidney Transplantation; Male; Membrane Proteins; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Postoperative Complications; Propanolamines; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Treatment Outcome; Tyrosine | 2002 |
33 other study(ies) available for tyrosine and cyclosporine
| Article | Year |
|---|---|
Monoclonal antibodies directed to different epitopes in the CD3-TCR complex induce different states of competence in resting human T cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcium; CD28 Antigens; Cyclosporine; Epitopes; Histocompatibility Antigens; Humans; Immunocompetence; Interleukin-2; Interleukin-4; Leukocyte Common Antigens; Lymphocyte Activation; Muromonab-CD3; Phosphorylation; Receptors, Antigen, T-Cell, alpha-beta; RNA, Messenger; T-Lymphocytes; Tyrosine | 1992 |
Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A.
Topics: Amino Acid Sequence; Calcineurin; Calmodulin-Binding Proteins; Cell Line; Cyclosporine; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Interleukin-1; Molecular Sequence Data; Peptides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphotyrosine; Protein Phosphatase 2; Recombinant Proteins; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Evidence that increases in lymphocyte tyrosine phosphorylation precede cardiac allograft rejection. Effects of cyclosporine and potential use in clinical management.
Topics: Animals; Biomarkers; Cyclosporine; Flow Cytometry; Graft Rejection; Heart Transplantation; Immunoenzyme Techniques; Immunophenotyping; Lymphocytes; Myocardium; Phosphorylation; Phosphotyrosine; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction; Swine; Transplantation, Homologous; Tyrosine | 1994 |
Early lymphocyte activation events are inhibited by antiproliferative synthetic peptide 2438, a fragment of human interferon alpha-2, and immunosuppressant cyclosporine A.
Topics: Calcium; Concanavalin A; Cyclosporine; Cytosol; Humans; Interferon-alpha; Interferons; Lymphocyte Activation; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphotyrosine; T-Lymphocytes; Tyrosine | 1994 |
Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes.
Topics: Anthralin; Cell Line; Cyclosporine; Humans; Immunohistochemistry; Indoles; Intracellular Fluid; Keratinocytes; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Psoriasis; Signal Transduction; Skin; Tacrolimus; Tyrosine | 1995 |
Fc gamma RII cross-linking inhibits anti-Ig-induced erg-1 and erg-2 expression in BCL1.
Topics: Animals; B-Lymphocytes; Cell Line; Cross-Linking Reagents; Cyclosporine; DNA-Binding Proteins; Early Growth Response Protein 1; Early Growth Response Protein 2; Female; Gene Expression; Immediate-Early Proteins; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphorylation; Receptors, Antigen, B-Cell; Receptors, IgG; RNA-Binding Proteins; Signal Transduction; Transcription Factors; Tyrosine | 1994 |
Tyrosine phosphorylation in psoriatic T cells is modulated by drugs that induce or improve psoriasis.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Cells, Cultured; Chloroquine; Cyclosporine; Ethanol; Female; Humans; Immunosuppressive Agents; Irritants; Lithium; Lymphocyte Activation; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Propranolol; Protein-Tyrosine Kinases; Psoriasis; T-Lymphocytes; Tacrolimus; Time Factors; Tyrosine | 1995 |
HIV protease substrate conformation: modulation by cyclophilin A.
Topics: Amino Acid Isomerases; Carrier Proteins; Catalysis; Cyclosporine; Enzyme Inhibitors; Gene Products, gag; HIV Protease; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Peptide Fragments; Peptidylprolyl Isomerase; Proline; Protein Conformation; Tyrosine | 1997 |
Activation induces apoptosis in Herpesvirus saimiri-transformed T cells independent of CD95 (Fas, APO-1).
Topics: Apoptosis; Cell Line, Transformed; Cell Transformation, Viral; Cyclosporine; fas Receptor; Herpesvirus 2, Saimiriine; Humans; Ligands; Lymphocyte Activation; Phosphorylation; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocyte Subsets; Cyclosporine; Enzyme Precursors; Female; Immune Tolerance; Immunologic Deficiency Syndromes; Intracellular Signaling Peptides and Proteins; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Mutant Strains; Phosphorylation; Protein-Tyrosine Kinases; src-Family Kinases; Substrate Specificity; Syk Kinase; Tacrolimus; Type C Phospholipases; Tyrosine; X Chromosome | 1998 |
Opposing effects of cyclosporin A and tyrphostin AG-1478 indicate a role for Src protein in the cellular control of mineralization.
Topics: Animals; Calcification, Physiologic; Cell Differentiation; Cells, Cultured; Cyclosporine; Dexamethasone; Enzyme Inhibitors; Female; Phosphorylation; Proteins; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Rats, Inbred Strains; Stromal Cells; Tyrosine; Tyrphostins | 1998 |
Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A.
Topics: Adenocarcinoma; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cyclosporine; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosuppressive Agents; Indole Alkaloids; Indoles; Integrins; Neoplasm Metastasis; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Sulfonamides; Tacrolimus; Tumor Cells, Cultured; Tyrosine | 1998 |
Suppressive effects of cyclosporin A and FK-506 on superoxide generation in human polymorphonuclear leukocytes primed by tumor necrosis factor alpha.
Topics: Cyclosporine; Depression, Chemical; Humans; Neutrophils; Phosphorylation; Superoxides; Tacrolimus; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction.
Topics: Animals; Antifungal Agents; Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Division; Cyclosporine; Furans; Heart Transplantation; HeLa Cells; Humans; Immunosuppressive Agents; Jurkat Cells; Lipids; Lymphocyte Activation; Molecular Structure; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred Lew; Rats, Wistar; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 2002 |
Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model.
Topics: Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Kidney; Kidney Transplantation; Leukocyte Count; Phosphorylation; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Receptors, Antigen, T-Cell; Reference Values; Stem Cells; Stilbenes; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Thymidine; Transplantation, Homologous; Tyrosine | 2002 |
Cyclosporin A disrupts bradykinin signaling through superoxide.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Animals; Antioxidants; Blotting, Western; Bradykinin; Cyclic GMP; Cyclosporine; Enzyme Activation; Free Radical Scavengers; GTP-Binding Proteins; Guanylate Cyclase; LLC-PK1 Cells; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Onium Compounds; Phospholipases; Quercetin; Receptor, Bradykinin B2; Receptors, Bradykinin; Signal Transduction; Solubility; Superoxides; Swine; Tyrosine; Vitamin K 3 | 2003 |
The involvement of calcineurin in acetylcholine receptor redistribution in muscle.
Topics: Agrin; Animals; Antibodies; Benzylamines; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Fetus; Growth Substances; Microspheres; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Signal Transduction; Sulfonamides; Synaptic Transmission; Tacrolimus; Tyrosine; Xenopus laevis | 2003 |
Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Catalysis; Cyclosporine; Gene Expression; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Malondialdehyde; Metalloporphyrins; Myocardium; Neutrophils; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Rats, Wistar; Tyrosine | 2005 |
Poly (ADP) ribose polymerase inhibition improves rat cardiac allograft survival.
Topics: Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Graft Survival; Heart Transplantation; Indoles; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Tyrosine | 2005 |
Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.
Topics: Aldehydes; Animals; Antioxidants; Blotting, Western; Buthionine Sulfoximine; Catalysis; Cell Line; Cell Survival; Cyclosporine; Cytochrome P-450 CYP2E1; DNA, Complementary; Endoplasmic Reticulum; Ethanol; Flow Cytometry; Glutathione; Humans; Liver; Liver Diseases, Alcoholic; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria; Mitochondria, Liver; Oxidative Stress; Plasmids; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Time Factors; Transfection; Tyrosine | 2006 |
Calcineurin regulates myocardial function during acute endotoxemia.
Topics: Animals; Calcineurin Inhibitors; Cats; Cyclosporine; Endotoxemia; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Contraction; Myocardium; Nitric Oxide Synthase Type II; Peroxidase; Protein Carbonylation; Superoxide Dismutase; Tacrolimus; Tyrosine | 2006 |
Cyclosporin A inhibits apolipoprotein A-I-induced early events in cellular cholesterol homeostasis in rat astrocytes.
Topics: Animals; Apolipoprotein A-I; Astrocytes; Blotting, Western; Cell Fractionation; Cholesterol; Cyclosporine; Embryo, Mammalian; Enzyme Inhibitors; Homeostasis; Humans; Immunoprecipitation; Lipid Metabolism; Phospholipase C gamma; Phosphorylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2006 |
Role of peroxynitrite in endothelial damage mediated by Cyclosporine A.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Endothelial Cells; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Cells, Cultured; Chloroform; Cyclosporine; Female; Glutathione; Hepatocytes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2007 |
Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.
Topics: Acute Disease; Aldehydes; Animals; Biomarkers; Brain Injuries; Cyclosporine; Dose-Response Relationship, Drug; Immunoblotting; Lipid Peroxidation; Male; Mice; Mitochondrial Diseases; Oxidative Stress; Oxygen Consumption; Structure-Activity Relationship; Tyrosine | 2008 |
Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria.
Topics: Animals; Apoptosis; Blotting, Western; Bongkrekic Acid; Cyclosporine; Cytochromes c; Diamide; Dimerization; Disulfides; Dithiothreitol; Enzyme Activation; Galactosamine; Glutathione; Glutathione Transferase; Lipopolysaccharides; Male; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reducing Agents; Sulfhydryl Reagents; Time Factors; Tyrosine | 2008 |
Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization.
Topics: Aldehydes; Animals; Apoptosis; Arginase; Biopterins; Cyclosporine; Cytokines; Echocardiography; Gene Expression; Graft Rejection; GTP Cyclohydrolase; Heart Transplantation; Heart Ventricles; Immunosuppressive Agents; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Pterins; Rats; Rats, Inbred Lew; Rats, Inbred WF; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine | 2009 |
Ultrastructural alterations in endothelial mitochondria are associated with enhanced nitrotyrosine accumulation and progressive reduction of VEGF expression in sequential protocol renal allograft biopsies with calcineurin inhibitor toxicity.
Topics: Adult; Biopsy; Calcineurin Inhibitors; Cyclosporine; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Kidney Transplantation; Male; Mitochondria; Tacrolimus; Transplantation, Homologous; Tyrosine; Vascular Endothelial Growth Factor A | 2010 |
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.
Topics: Aconitate Hydratase; Animals; Cattle; Cell Respiration; Cells, Cultured; Cyclosporine; Electron Spin Resonance Spectroscopy; Endothelial Cells; Immunosuppressive Agents; Mass Spectrometry; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Superoxides; Transfection; Tyrosine | 2010 |
Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.
Topics: Catalytic Domain; Cell Line, Tumor; Cyclophilin A; Cyclophilins; Cyclosporine; Genetic Predisposition to Disease; Genotype; Hepacivirus; Humans; Immunosuppressive Agents; Mutagenesis; Mutation; Protein Binding; Tyrosine; Viral Nonstructural Proteins | 2010 |
Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity.
Topics: Animals; Antibodies; Clodronic Acid; Cyclosporine; Diuresis; Glomerular Filtration Rate; Hemodynamics; Immunosuppressive Agents; Kidney; Kidney Function Tests; Macrophages; Male; NF-kappa B; Nitric Oxide; Rats; Rats, Wistar; Renal Circulation; Tyrosine; Vascular Resistance; Vimentin | 2010 |
Previous exposure to cigarette smoke aggravates experimental cyclosporine-induced nephrotoxicity.
Topics: Actins; Animals; Cyclosporine; Disease Models, Animal; Drug Synergism; Fibrosis; Glomerular Filtration Rate; Hematocrit; Hemodynamics; Humans; Immunosuppressive Agents; Kidney; Male; Nephritis, Interstitial; Rats; Rats, Wistar; Smoking; Tyrosine; Vimentin | 2012 |
Modulation of calcineurin signaling during development.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Down Syndrome; Intracellular Signaling Peptides and Proteins; Tacrolimus; Tyrosine; Zebrafish | 2022 |