tyrosine has been researched along with benzoxazoles in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 9 (29.03) | 2.80 |
| Authors | Studies |
|---|---|
| Hildmann, H; Koburg, E; Steinbach, E | 1 |
| Ferguson, SJ; Sutton, R | 1 |
| Myerowitz, R; Pratt, RF; Wolozin, BL | 1 |
| Evans, DB; Fan, N; Rank, KB; Sharma, SK; Tarpley, WG; Thomas, RC | 1 |
| Cheung, H; Hill, CM; Janc, JW; Martichonok, V; McGrath, ME; Palmer, JT; Somoza, JR; Sprengeler, PA | 1 |
| Anzai, N; Endo, H; Endou, H; Hosoda, N; Kanai, Y; Oda, K; Saito, K; Sakata, T; Tsujihara, K; Wempe, MF; Yamamura, M | 1 |
| Anzai, N; Endou, H; Hayashi, M; Jutabha, P; Kusuhara, H; Lightner, JW; Rice, PJ; Sugiyama, Y; Wakui, S; Wempe, MF | 1 |
| Civiello, RL; Conway, CM; Cook, DA; Davis, CD; Degnan, AP; Dubowchik, GM; Han, X; Jiang, XJ; Macci, R; Macor, JE; Mathias, NR; Moench, P; Pin, SS; Schartman, R; Signor, LJ; Thalody, G; Tora, G; Whiterock, V; Xu, C | 1 |
| Kerwin, BA; Mozziconacci, O; Schöneich, C; Zhou, S | 1 |
| Endou, H; Kusuhara, H; Sugiyama, Y; Toyoshima, J; Wempe, MF | 1 |
| Chun, HS; Endou, H; Kanai, Y; Kim, CS; Kim, DK; Kim, HJ; Kim, JS; Kim, SG; Lee, SA; Oh, JS; Park, MG; Park, MR; Wempe, MF; Yu, SK; Yun, DW | 1 |
| Endou, H; Kawada, A; Kimura, T; Ochiai, T; Sakurai, H; Ueno, S; Yamaga, T | 1 |
| Anzai, N; Chida, M; Endou, H; Fujita, T; Hayashi, K; Jutabha, P; Maeda, S; Ouchi, M; Supak, Y | 1 |
| Anzai, N; Dokduang, H; Endou, H; Hayashi, K; Jutabha, P; Loilome, W; Namwat, N; Sangkhamanon, S; Yongvanit, P; Yothaisong, S | 1 |
| Akosman, I; Dosier, LBM; McMahon, TJ; Premkumar, VJ; Wempe, MF; Zhu, H | 1 |
| Bommana, R; John Wang, Y; Mozziconacci, O; Schöneich, C | 1 |
| Dong, T; Fukunaga, K; Ibata, T; Imachi, H; Iwama, H; Kobayashi, T; Lyu, J; Murao, K; Sato, S; Yonezaki, K; Yoshimoto, T; Zhang, G | 1 |
| Altmann, KH; Charles, RP; Dettmer, MS; Gertsch, J; Graff, J; Häfliger, P; Rubin, M; Stooss, A | 1 |
| Anzai, N; Furihata, T; Higuchi, K; Kaneko, M; Matsubara, H; Morio, H; Muto, Y; Okunushi, K; Reien, Y; Uesato, M | 1 |
| Cormerais, Y; Endou, H; Giuliano, S; Pagès, G; Pagnuzzi-Boncompagni, M; Picco, V; Pouysségur, J; Schrötter, S; Tambutté, E; Wempe, MF | 1 |
| Anzai, N; Endou, H; Fujita, T; Hayashi, K; Hiroi, T; Iwata, Y; Jutabha, P; Kaminuma, O; Kanai, Y; Kurasawa, K; Matsuoka, K; Nishimura, T; Okayasu, I; Ouchi, M; Owada, T; Saeki, M; Sugiura, K | 1 |
| Enomoto, K; Gunduz, M; Hotomi, M; Muragaki, Y; Onoda, N; Sato, F; Tamagawa, S; Uchino, S | 1 |
| Ando, K; Anzai, N; Furihata, T; Higuchi, K; Ichikawa, T; Ikehara, Y; Imamura, Y; Maimaiti, M; Matsushima, J; Nakamura, K; Okunushi, K; Reien, Y; Sakamoto, S; Sazuka, T; Takeshita, N | 1 |
| Endou, H; Fujita, T; Hayashi, K; Kaminuma, O; Nishimura, T; Ogata, S; Saeki, M; Yamasaki, N | 1 |
| Ando, K; Anzai, N; Furihata, T; Higuchi, K; Ichikawa, T; Ikehara, Y; Imamura, Y; Kanai, Y; Kaneda, A; Kyprianou, N; Maimaiti, M; Nakamura, K; Rii, J; Sakamoto, S; Sazuka, T; Sugiura, M; Takeuchi, N; Xu, M; Yamada, Y | 1 |
| Cronk, S; Dinara, S; Ikhlef, H; Massaro, C; Moots, H; Phanstiel, O; Thomas, J | 1 |
| Huttunen, J; Huttunen, KM; Markowicz-Piasecka, M; Montaser, A | 1 |
| Anzai, N; Furihata, T; Higuchi, K; Kaneko, M; Morio, H; Muto, Y; Nakagawa, K; Ohno, Y; Okunushi, K; Otsuka, Y; Reien, Y; Sakamoto, S; Shimojo, N; Wakashin, H; Watanabe, Y | 1 |
| Endou, H; Kanai, Y; Ohgaki, R; Okanishi, H; Okuda, S | 1 |
| Sakurai, H; Suehiro, J; Wada, Y; Yamaga, T | 1 |
| Brunocilla, C; Console, L; Indiveri, C; Rovella, F | 1 |
31 other study(ies) available for tyrosine and benzoxazoles
| Article | Year |
|---|---|
[Fate of cialite preserved homologous transplants in the middle ear. Autoradiographic studies of fascia and bone].
Topics: Animals; Autoradiography; Benzoxazoles; Bone Regeneration; Bone Transplantation; Ethylmercury Compounds; Fascia; Methods; Phenylalanine; Rabbits; Tissue Preservation; Transplantation, Homologous; Tritium; Tyrosine | 1972 |
The nature of the reaction of an essential tyrosine residue of bovine heart mitochondrial ATPase with 4-chloro-7-nitrobenzofurazan and related compounds.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Benzoxazoles; Cattle; Chemical Phenomena; Chemical Precipitation; Chemistry; Fluorobenzenes; Kinetics; Lysine; Mitochondria, Heart; Oxadiazoles; Proton-Translocating ATPases; Tyrosine | 1984 |
Specific chemical modification of the readily nitrated tyrosine of the RTEM beta-lactamase and of bacillus cereus beta-lactamase I. The role of the tyrosine in beta-lactamase catalysis.
Topics: Acetylation; Bacillus cereus; Benzoxazoles; beta-Lactamases; Binding Sites; Chemical Phenomena; Chemistry; Dithionite; Escherichia coli; Imidazoles; Oxidation-Reduction; Sulfhydryl Reagents; Tetranitromethane; Tyrosine | 1982 |
Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s.
Topics: Amino Acid Sequence; Antiviral Agents; Benzodiazepines; Benzoxazoles; Cloning, Molecular; Delavirdine; HIV Reverse Transcriptase; HIV-1; HIV-2; Imidazoles; Indoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Nevirapine; Piperazines; Point Mutation; Pyridines; Pyridones; Recombinant Fusion Proteins; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tyrosine | 1995 |
Peptide ketobenzoxazole inhibitors bound to cathepsin K.
Topics: Animals; Aspartic Acid; Benzoxazoles; Binding Sites; Cathepsin K; Cathepsins; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Kinetics; Models, Molecular; Oligopeptides; Rabbits; Recombinant Proteins; Tyrosine; Valine | 2003 |
L-type amino acid transporter 1 inhibitors inhibit tumor cell growth.
Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents; Benzoxazoles; Cell Proliferation; Fusion Regulatory Protein 1, Light Chains; HT29 Cells; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Large Neutral Amino Acid-Transporter 1; Leucine; Male; Mice; Mice, Inbred BALB C; Protein Serine-Threonine Kinases; TOR Serine-Threonine Kinases; Tyrosine; Xenograft Model Antitumor Assays | 2010 |
Metabolism and pharmacokinetic studies of JPH203, an L-amino acid transporter 1 (LAT1) selective compound.
Topics: Acetylation; Animals; Antineoplastic Agents; Benzoxazoles; Biotransformation; Dogs; Humans; Intestine, Small; Kidney; Large Neutral Amino Acid-Transporter 1; Liver; Macaca fascicularis; Male; Membrane Transport Modulators; Mice; Microsomes; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tyrosine | 2012 |
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Topics: Administration, Intranasal; Amino Acids; Animals; Benzoxazoles; Biological Availability; Calcitonin Gene-Related Peptide Receptor Antagonists; Half-Life; Indazoles; Protein Binding; Quinazolinones; Rabbits; Receptors, Calcitonin Gene-Related Peptide; Structure-Activity Relationship; Tyrosine | 2013 |
Fluorogenic tagging methodology applied to characterize oxidized tyrosine and phenylalanine in an immunoglobulin monoclonal antibody.
Topics: Ascorbic Acid; Benzoxazoles; Copper; Immunoglobulin G; Oxidation-Reduction; Phenylalanine; Spectrometry, Fluorescence; Tyrosine | 2013 |
Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203.
Topics: Animals; Antineoplastic Agents; Benzoxazoles; Bile; HEK293 Cells; Hepatocytes; Humans; Large Neutral Amino Acid-Transporter 1; Male; Neoplasms; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells.
Topics: Amino Acid Transport System L; Antineoplastic Agents; Apoptosis; Benzoxazoles; Caspases; Fusion Regulatory Protein 1, Heavy Chain; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Mouth Neoplasms; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 2014 |
Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoglycemic Agents; Large Neutral Amino Acid-Transporter 1; Leucine; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice, Inbred BALB C; Mice, Nude; Multiprotein Complexes; TOR Serine-Threonine Kinases; Tyrosine | 2016 |
LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells.
Topics: Amino Acids; Benzoxazoles; Cell Line, Tumor; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Thymoma; Thymus Neoplasms; Tyrosine | 2016 |
Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment.
Topics: Animals; Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Mice; Molecular Targeted Therapy; Tyrosine; Xenograft Model Antitumor Assays | 2017 |
Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells.
Topics: Amino Acid Transport System L; Amino Acids, Cyclic; Animals; Benzoxazoles; Cell Adhesion; Cysteine; Endothelial Cells; Erythrocyte Deformability; Erythrocytes; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Leucine; Mice; Mice, Nude; Reticulocytes; RNA, Messenger; S-Nitrosothiols; Tyrosine | 2017 |
An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization.
Topics: Animals; Benzoxazoles; Calibration; Catalysis; Cattle; Drug Stability; Fluorescence; Human Growth Hormone; Humans; Immunoglobulin G; Insulin; Methionine; Oxidation-Reduction; Peroxides; Phenylalanine; Proteolysis; Serum Albumin, Bovine; Tyrosine | 2017 |
Selective peroxisome proliferator-activated receptor-α modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells.
Topics: Animals; ATP Binding Cassette Transporter 1; Benzoxazoles; Butyrates; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Glucose; Glucose Intolerance; Humans; Hypolipidemic Agents; Insulin; Insulin-Secreting Cells; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Rats; RNA, Messenger; Tyrosine | 2018 |
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins B-raf; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Gland; Tyrosine | 2018 |
Different Response Profiles of Gastrointestinal Cancer Cells to an L-Type Amino Acid Transporter Inhibitor, JPH203.
Topics: Apoptosis; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Tyrosine | 2019 |
Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.
Topics: Activating Transcription Factor 4; Animals; Antineoplastic Agents; Astrocytes; Benzoxazoles; Cell Line; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Cerebellum; Child; Embryo, Mammalian; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Mechanistic Target of Rapamycin Complex 1; Medulloblastoma; Mice; Neurons; Organ Specificity; Primary Cell Culture; Protein Serine-Threonine Kinases; Tyrosine | 2019 |
LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation.
Topics: Amino Acid Transport System y+L; Animals; Benzoxazoles; CD4-Positive T-Lymphocytes; Cells, Cultured; Dermatitis, Atopic; Disease Models, Animal; Humans; Large Neutral Amino Acid-Transporter 1; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Knockout; Signal Transduction; Th2 Cells; Treatment Outcome; Tyrosine | 2020 |
A novel therapeutic approach for anaplastic thyroid cancer through inhibition of LAT1.
Topics: Animals; Antineoplastic Agents; Benzoxazoles; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Mice; Molecular Targeted Therapy; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Tyrosine; Xenograft Model Antitumor Assays | 2019 |
Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma.
Topics: Benzoxazoles; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Kidney Neoplasms; Large Neutral Amino Acid-Transporter 1; Male; Middle Aged; Prognosis; Progression-Free Survival; Retrospective Studies; Tyrosine | 2019 |
L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness.
Topics: Activating Transcription Factor 4; Animals; Benzoxazoles; Cytokines; Disease Models, Animal; gamma-Glutamylcyclotransferase; Large Neutral Amino Acid-Transporter 1; Lymphocyte Activation; Mice; Rhinitis, Allergic; Signal Transduction; T-Lymphocytes; Tyrosine | 2020 |
Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma.
Topics: Benzoxazoles; Cell Line, Tumor; Disease-Free Survival; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Male; MAP Kinase Signaling System; Neoplasm Proteins; Survival Rate; TOR Serine-Threonine Kinases; Tyrosine; Urinary Bladder Neoplasms | 2020 |
Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors.
Topics: Animals; Benzoxazoles; Biological Transport; CHO Cells; Cricetulus; Drug Discovery; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Methionine; Polyamines; Putrescine; Small Molecule Libraries; Spermidine; Spermine; Tyrosine | 2020 |
Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazoles; Brain; Brain Chemistry; Carboxylic Acids; Drug Synergism; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Injections, Intraperitoneal; Large Neutral Amino Acid-Transporter 1; Leucine; Male; MCF-7 Cells; Mice; Myocytes, Smooth Muscle; NF-kappa B; Norbornanes; Primary Cell Culture; Pyridines; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tyrosine | 2020 |
JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function.
Topics: Adenocarcinoma; Antineoplastic Agents; Benzoxazoles; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Time Factors; Tyrosine | 2020 |
Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor.
Topics: Benzoxazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytostatic Agents; Humans; Large Neutral Amino Acid-Transporter 1; Proteomics; Tyrosine | 2021 |
Induction of CTH expression in response to amino acid starvation confers resistance to anti-LAT1 therapy in MDA-MB-231 cells.
Topics: Amino Acids; Antineoplastic Agents; Benzoxazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cystathionine gamma-Lyase; Female; Gene Knockdown Techniques; Humans; Large Neutral Amino Acid-Transporter 1; RNA, Small Interfering; Tyrosine | 2022 |
Insights into the Transport Cycle of LAT1 and Interaction with the Inhibitor JPH203.
Topics: Benzoxazoles; Biological Transport; Blood-Brain Barrier; Brain; Humans; Large Neutral Amino Acid-Transporter 1; Neoplasms; Tyrosine | 2023 |