tyrosine has been researched along with arachidonic acid in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (6.86) | 18.7374 |
| 1990's | 58 (56.86) | 18.2507 |
| 2000's | 30 (29.41) | 29.6817 |
| 2010's | 6 (5.88) | 24.3611 |
| 2020's | 1 (0.98) | 2.80 |
| Authors | Studies |
|---|---|
| Kulmacz, RJ; Palmer, G; Tsai, AL | 1 |
| Curtis, JF; DeGray, JA; Eling, TE; Kennedy, TA; Lassmann, G; Marnett, LJ; Mason, RP | 1 |
| Beaven, MA; Jelsema, CL; Yamada, K | 1 |
| Gilfillan, AM; Hakimi, J; Kado-Fong, H; Kent, U; Kochan, JP; Wiggan, GA | 1 |
| Curtis, JF; DeGray, JA; Eling, TE; Lassmann, G; Marnett, LJ; Mason, RP; Odenwaller, R | 1 |
| Fischer, JE; Hasselgren, PO; James, JH; Zamir, O | 1 |
| Evans, J; Shaw, KP; Vernon, LP; Wang, YD | 1 |
| Dietz, R; Karthein, R; Nastainczyk, W; Ruf, HH | 1 |
| McKinley, CJ; Turinsky, J | 1 |
| Dietz, R; Nastainczyk, W; Ruf, HH | 1 |
| Odessey, R | 1 |
| Badwey, JA; Curnutte, JT; Karnovsky, MJ; Karnovsky, ML; Robinson, JM | 1 |
| Fujimoto, T; Kambayashi, J; Kosaki, G; Nomura, T | 1 |
| Domin, J; Higgins, T; Rozengurt, E | 1 |
| Bybee, A; Khwaja, A; Lie, AK; Linch, DC; Roberts, PJ; Thomas, NS; Yong, K | 1 |
| Dunn, MJ; Herman, WH; Simonson, MS | 1 |
| Abu-Lawi, KI; Sultzer, BM | 1 |
| Beaven, MA; Hirasawa, N; Kinet, JP; Scharenberg, A; Yamamura, H | 1 |
| Adachi, T; Nakamura, T; Nakashima, S; Nozawa, Y; Saji, S | 1 |
| Javors, MA; Leeb-Lundberg, LM; McAllister, BS; Olson, MS | 1 |
| Baldassare, JJ; Elder, JT; Fisher, GJ; Henderson, PA; Reynolds, NJ; Talwar, HS; Voorhees, JJ | 1 |
| Beaven, MA; Santini, F | 1 |
| Kulmacz, RJ; Palmer, G; Tsai, A | 1 |
| LaVoie, HA; Witorsch, RJ | 1 |
| Chio, CL; Huff, RM; Lajiness, ME | 1 |
| Buckley, BJ; Whorton, AR | 2 |
| Leslie, CC; Qiu, ZH | 1 |
| Dangelmaier, C; Daniel, JL; Smith, JB | 1 |
| Chatani, Y; Kohno, M; Miyoshi, N; Nakamura, M; Nakashima, S; Nozawa, Y | 1 |
| Jackson, SP; Mitchell, CA; Schoenwaelder, SM; Yuan, Y | 1 |
| Bakovic, M; Dunford, HB | 1 |
| Bhattacharyya, DK; Garavito, M; Lecomte, M; Rieke, CJ; Smith, WL | 1 |
| Bae, YS; Hwang, SC; Jhon, DY; Kim, JH; Rhee, SG | 1 |
| Alonso, A; Bayón, Y; Crespo, MS | 1 |
| Ashour, MS; Fouda, SI; Molski, TF; Sha'afi, RI | 1 |
| Boyar, WC; Kulmacz, RJ; Marshall, PJ; Palmer, G; Tsai, AL; Xiao, G | 1 |
| Halldórsson, H; Helgadóttir, A; Kjeld, M; Magnúsdóttir, K; Thorgeirsson, G | 1 |
| Polgar, P; Prado, GN; Taylor, L | 1 |
| Gibbins, JM; Poole, A; Saito, T; Turner, M; Tybulewicz, VL; van de Winkel, JG; van Vugt, MJ; Watson, SP | 1 |
| Curtis, JF; Eling, TE; Gierse, JK; Gunther, MR; Hsi, LC; Marnett, LJ; Mason, RP | 1 |
| Murai, A; Nakahata, N; Nakamura, H; Ohizumi, Y; Rho, MC | 1 |
| Angerman-Stewart, J; Eling, TE; Everhart, AL; Glasgow, WC; Han, BB; Hui, R; Jayawickreme, SP | 1 |
| Kulmacz, RJ; Tsai, AL; Wu, G | 1 |
| Matsuoka, I; Nakahata, N; Nakanishi, H | 1 |
| Kulmacz, RJ; Palmer, G; Swinney, DC; Tsai, Al; Xiao, G | 1 |
| Callan, OH; Mak, AY; Scarafia, LE; So, OY; Swinney, DC | 1 |
| Nakahata, N; Ohizumi, Y; Rho, M | 1 |
| Dugué, B; Ekokoski, E; Törnquist, K | 1 |
| Crews, BC; Eling, TE; Goodwin, DC; Gunther, MR; Hsi, LC; Marnett, LJ; Mason, RP | 1 |
| DeWitt, DL; Shankavaram, UT; Wahl, LM | 1 |
| Mierke, DF; Pellegrini, M; Polgar, P; Prado, GN; Taylor, L | 1 |
| Medalia, O; Sagi-Eisenberg, R; Shefler, I; Taube, Z | 1 |
| Douglas, JG; Dulin, NO; Sorokin, A | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Faul, JD; Huang, J; Lucchesi, BR; Rebello, SS | 1 |
| Bae, YS; Hwang, SC; Jhon, DY; Rhee, SG; Sekiya, F | 1 |
| Bae, YS; Rhee, SG; Sekiya, F | 1 |
| Shiao, MS; Su, CY; Wang, CT | 1 |
| Banfi, C; Battaini, F; Cattaneo, MG; Galli, C; Mussoni, L; Risé, P; Tremoli, E; Vicentini, L | 1 |
| Fisher, I; Ritter, JM; Robinson, P | 1 |
| Guittet, O; Lepoivre, M; Roy, B | 1 |
| Kerkhoff, C; Nacken, W; Sopalla, C; Sorg, C; Vogl, T | 1 |
| Bianchi, PC; Joubert, AM; Joubert, F; Lottering, ML; Panzer, A; Seegers, JC | 1 |
| Goodwin, DC; Marnett, LJ; Rowlinson, SW | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Krutetskaia, NI; Krutetskaia, ZI; Lebedev, OE | 1 |
| Casonato, A; Deana, R; Francesconi, M; Girolami, A; Scapin, M | 1 |
| Rodrigues, HL | 1 |
| Asaka, Y; Kodama, H; Lu, HW; Manabe, M; Masuoka, N; Sagara, Y; Sugahara, K | 1 |
| Akiba, S; Hayama, M; Kitatani, K; Sato, T | 1 |
| Nakahata, N; Nakatani, K; Ohizumi, Y; Tsurufuji, S | 1 |
| Alonso, A; Holloschi, A; Kabsch, K; Kaszkin, M; Mao, X; Marqués, MM; Rodríguez, I | 1 |
| Kulmacz, RJ; Okeley, NM; Palmer, G; Peng, S; Tsai, AL; van der Donk, WA; Wu, G | 1 |
| Chen, G; Kodama, H; Lu, H; Lu, J; Manabe, M; Sagara, Y; Yamashita, K; Yokoyama, T | 1 |
| Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Kulmacz, RJ; Tsai, AL; van der Donk, WA | 1 |
| Chen, G; Kodama, H; Lu, H; Manabe, M; Wang, C; Yamashita, K | 1 |
| Cederbaum, AI; Pérez, MJ | 1 |
| Carattino, MD; Hill, WG; Kleyman, TR | 1 |
| Kalgutkar, AS; Kiefer, JR; Kozak, KR; Kurumbail, RG; Marnett, LJ; Pawlitz, JL; Prusakiewicz, JJ; Rowlinson, SW; Stallings, WC | 1 |
| Chen, G; Kitaoka, N; Kodama, H; Lu, H; Manabe, M; Sagara, Y; Song, S; Wang, Z; Xu, S | 1 |
| Bolton, ED; Braunstein, JB; Chiles, KA; Faraday, N; Gerstenblith, G; Heldman, AW; Schulman, SP | 1 |
| Bae, DS; Bae, YS; Ha, KS; Lee, IH; Rhee, SG; Suh, PG; You, JO | 1 |
| Bianchi, M; Cantoni, O; Colasanti, M; Magnani, M; Palomba, L; Persichini, T | 1 |
| Kaduce, TL; Lee, HC; Spector, AA; Wang, XL; Zhou, W | 1 |
| Nakano, N; Nakao, A; Ogawa, H; Okumura, K; Shirasaka, N; Tsuboi, R; Uchida, T; Yoshizumi, H | 1 |
| Kodama, H; Liu, G; Manabe, M; Song, SJ; Yagi-Chaves, SN; Yamashita, K | 1 |
| Chen, YJ; Li, J; Quilley, J | 2 |
| Deeb, RS; Hajjar, DP; Upmacis, RK | 1 |
| Carter, CB; Dearman, JA; Hester, RL; Hodnett, BL | 1 |
| Hein, TW; Kuo, L; Qamirani, E; Ren, Y | 1 |
| Kulmacz, RJ; Liu, W; Rogge, CE; Tsai, AL | 1 |
| Cheung, C; Deeb, RS; Gross, SS; Hajjar, DP; Lamon, BD; Nuriel, T; Upmacis, RK | 1 |
| Cantoni, O; Cerioni, L; Palomba, L | 1 |
| Chen, YJ; Quilley, J; Santos, M | 1 |
| Kulmacz, RJ; Lü, JM; Tsai, AL; van der Donk, WA; Wu, G | 1 |
| Gerfen, GJ; Kulmacz, RJ; Lü, JM; Palmer, G; Peng, S; Rogge, CE; Tsai, AL; van der Donk, WA; Wu, G | 1 |
| Christov, CZ; Coveney, PV; Karabencheva-Christova, TG; Lodola, A; Mulholland, AJ; Wan, S | 1 |
| Wang, L; Wu, S; Yu, Z; Zhao, W | 1 |
6 review(s) available for tyrosine and arachidonic acid
| Article | Year |
|---|---|
Role of the platelet integrin glycoprotein IIb-IIIa in intracellular signalling.
Topics: Arachidonic Acid; Cell Communication; Humans; Phosphatidylinositols; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Signal Transduction; Tyrosine | 1993 |
Regulation of phospholipase C isozymes: activation of phospholipase C-gamma in the absence of tyrosine-phosphorylation.
Topics: Animals; Arachidonic Acid; Enzyme Activation; Humans; Isoenzymes; Phosphatidic Acids; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phospholipase C gamma; Phospholipase D; Phospholipases A; Phospholipases A2; Phosphorylation; Second Messenger Systems; Type C Phospholipases; Tyrosine | 1999 |
Nitric oxide: a radical molecule in quest of free radicals in proteins.
Topics: Amino Acids; Animals; Arachidonic Acid; Bacterial Proteins; Binding Sites; Free Radicals; Humans; Iron; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Prostaglandin-Endoperoxide Synthases; Proteins; Tyrosine | 1999 |
[Update on the treatment with platelet antiaggregation agents].
Topics: Abciximab; Adenosine Diphosphate; Antibodies, Monoclonal; Arachidonic Acid; Cell Membrane; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Tirofiban; Tyrosine | 2001 |
The cyclooxygenase reaction mechanism.
Topics: Animals; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Free Radicals; Humans; Isoenzymes; Membrane Proteins; Molecular Conformation; Peroxidase; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Tyrosine | 2002 |
Oxidative alterations of cyclooxygenase during atherogenesis.
Topics: Animals; Arachidonic Acid; Atherosclerosis; Cyclooxygenase Inhibitors; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Heme; Humans; Intramolecular Oxidoreductases; MAP Kinase Signaling System; Nitric Oxide; Nitrogen Oxides; Oxidation-Reduction; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Tyrosine | 2006 |
1 trial(s) available for tyrosine and arachidonic acid
| Article | Year |
|---|---|
Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Arachidonic Acid; Aspirin; Blood Platelets; C-Reactive Protein; Cell Aggregation; Drug Resistance; Eptifibatide; Female; Heparin; Humans; Leukocytes; Male; Middle Aged; Monocytes; Multivariate Analysis; Myocardial Infarction; Myocardial Ischemia; Neutrophils; Patient Selection; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Receptors, Thrombin; Recurrence; ROC Curve; Tirofiban; Treatment Outcome; Troponin I; Tyrosine | 2004 |
95 other study(ies) available for tyrosine and arachidonic acid
| Article | Year |
|---|---|
Prostaglandin H synthase. Kinetics of tyrosyl radical formation and of cyclooxygenase catalysis.
Topics: Animals; Arachidonic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Kinetics; Lipid Peroxides; Male; Microsomes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Time Factors; Tyrosine | 1992 |
Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase.
Topics: Alkenes; Animals; Arachidonic Acid; Computer Simulation; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Male; Microsomes; Peroxides; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Spin Labels; Tyrosine | 1992 |
Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.
Topics: Alkaloids; Androstadienes; Angiotensin I; Animals; Antigens; Arachidonic Acid; Basophils; Calcimycin; Carbazoles; Exocytosis; In Vitro Techniques; Indoles; Inositol Phosphates; Leukemia, Experimental; Maleimides; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine; Wortmannin | 1992 |
Conservation of signal transduction mechanisms via the human Fc epsilon RI alpha after transfection into a rat mast cell line, RBL 2H3.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Arachidonic Acid; Calcium; Cell Line; Histamine Release; Immunoglobulin E; Inositol Phosphates; Mast Cells; Phosphorylation; Rats; Receptors, Fc; Receptors, IgE; Signal Transduction; Transfection; Tyrosine | 1992 |
Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.
Topics: Alkenes; Animals; Arachidonic Acid; Catalysis; Chromatography, High Pressure Liquid; Eicosanoids; Electron Spin Resonance Spectroscopy; Free Radicals; Indomethacin; Male; Microwaves; Peroxides; Phenol; Phenols; Prostaglandin-Endoperoxide Synthases; Protoporphyrins; Sheep; Tyrosine | 1991 |
Prostaglandin E2 does not regulate total or myofibrillar protein breakdown in incubated skeletal muscle from normal or septic rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cycloheximide; Dinoprostone; In Vitro Techniques; Indomethacin; Male; Methylhistidines; Muscle Proteins; Rats; Rats, Inbred Strains; Sepsis; Tyrosine | 1990 |
Cellular responses to Pyrularia thionin are mediated by Ca2+ influx and phospholipase A2 activation and are inhibited by thionin tyrosine iodination.
Topics: Animals; Antimicrobial Cationic Peptides; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Cell Survival; Cells, Cultured; Dexamethasone; Enzyme Activation; Hemolysis; Humans; Indomethacin; Iodides; Membrane Potentials; Mice; Muscles; Phospholipases; Phospholipases A; Phospholipases A2; Plant Proteins; Quinacrine; Seeds; Tyrosine | 1989 |
Higher oxidation states of prostaglandin H synthase. EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Electron Spin Resonance Spectroscopy; Free Radicals; Microwaves; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Protein Conformation; Sheep; Tyrosine | 1988 |
Prostaglandin E2 and muscle proteolysis: effect of burn injury and cycloheximide.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Burns; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Male; Muscles; Prostaglandins E; Proteins; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Hydrogen Peroxide; Kinetics; Oxidation-Reduction; Peroxidases; Prostaglandin Endoperoxides; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Sheep; Spectrum Analysis; Tyrosine | 1988 |
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniques; Indomethacin; Leupeptins; Lysosomes; Muscles; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Proteins; Quinacrine; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate.
Topics: Arachidonic Acid; Arachidonic Acids; Humans; In Vitro Techniques; Linoleic Acid; Linoleic Acids; Neutrophils; Protease Inhibitors; Sulfonamides; Superoxides; Trifluoperazine; Tyrosine | 1984 |
The analysis of platelet reaction, utilizing various inhibitors of platelet aggregation.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Gabexate; Guanidines; Humans; Leupeptins; Platelet Aggregation; Protease Inhibitors; Tosyl Compounds; Tyrosine | 1980 |
Preferential inhibition of platelet-derived growth factor-stimulated DNA synthesis and protein tyrosine phosphorylation by nordihydroguaiaretic acid.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Cell Line; Cell Nucleus; Cells, Cultured; Dinoprostone; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Insulin; Masoprocol; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Rats; Skin; Thymidine; Tyrosine | 1994 |
Differentiation-linked changes in tyrosine phosphorylation, functional activity, and gene expression downstream from the granulocyte-macrophage colony-stimulating factor receptor.
Topics: Arachidonic Acid; CD18 Antigens; Cell Differentiation; Cell Division; Cell Line; Dimethyl Sulfoxide; Gene Expression; Genes, fos; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Integrins; Kinetics; Leukemia, Promyelocytic, Acute; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; Superoxides; Time Factors; Tumor Cells, Cultured; Tyrosine | 1994 |
PGE2 induces c-fos expression by a cAMP-independent mechanism in glomerular mesangial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acid; Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Genes, jun; Glomerular Mesangium; Male; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Regulatory Sequences, Nucleic Acid; RNA, Messenger; TATA Box; Transcription Factor AP-1; Tyrosine | 1994 |
Induction of serine and threonine protein phosphorylation by endotoxin-associated protein in murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Bacterial Proteins; Dinoprostone; Endotoxins; Female; Ionomycin; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor.
Topics: Animals; Antigens; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Cycle Proteins; Cell Line; Enzyme Activation; Enzyme Precursors; GTP-Binding Proteins; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mast Cells; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Rats; Receptor Aggregation; Receptors, IgE; Receptors, Muscarinic; Recombinant Proteins; Signal Transduction; Swine; Syk Kinase; Transfection; Tyrosine | 1995 |
Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; DNA; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Indomethacin; Kinetics; Liver; Male; Phospholipases A; Phospholipases A2; Phosphotyrosine; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 1995 |
Bradykinin receptors and signal transduction pathways in human fibroblasts: integral role for extracellular calcium.
Topics: Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Dinoprostone; Fibroblasts; Gingiva; Growth Substances; Humans; In Vitro Techniques; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Receptors, Bradykinin; Receptors, Neurotransmitter; Signal Transduction; Tyrosine | 1993 |
Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes.
Topics: Arachidonic Acid; Cells, Cultured; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Hydrolysis; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Keratinocytes; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphatidylcholines; Phospholipase D; Phosphorylation; Phosphotyrosine; Protein Kinase C; Proteins; Transforming Growth Factor alpha; Type C Phospholipases; Tyrosine | 1993 |
Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. Studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells.
Topics: Actins; Animals; Arachidonic Acid; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Electrophoresis, Polyacrylamide Gel; Exocytosis; Hexosaminidases; Hydrogen Peroxide; Inositol Phosphates; Kinetics; Leukemia, Basophilic, Acute; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Tumor Cells, Cultured; Tyrosine; Vanadates | 1993 |
Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.
Topics: Animals; Arachidonic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen Peroxide; Indomethacin; Male; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Tyrosine | 1995 |
Investigation of intracellular signals mediating the anti-apoptotic action of prolactin in Nb2 lymphoma cells.
Topics: Animals; Apoptosis; Arachidonic Acid; Dexamethasone; DNA Damage; Lymphoma; Male; Ornithine Decarboxylase; Phosphorylation; Prolactin; Protein Kinase C; Rats; Tumor Cells, Cultured; Tyrosine | 1995 |
D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations.
Topics: Animals; Arachidonic Acid; Cell Division; CHO Cells; Cricetinae; Cyclic AMP; Dopamine; Dopamine Agents; Mitogens; Phosphorylation; Rats; Receptors, Dopamine D2; Signal Transduction; Stimulation, Chemical; Thymidine; Transfection; Tritium; Tyrosine | 1993 |
Ca(2+)-independent arachidonic acid release by vascular endothelium requires protein synthesis de novo.
Topics: Aluminum Compounds; Animals; Arachidonic Acid; Calcium; Cells, Cultured; Cycloheximide; Dactinomycin; Endothelium, Vascular; Enzyme Activation; Fluorides; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Biosynthesis; Swine; Tyrosine; Vanadates | 1994 |
Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; Indoles; Isoenzymes; Macrophages, Peritoneal; Maleimides; Mice; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Zymosan | 1994 |
Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization.
Topics: Alkaloids; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; Indoles; Inositol Phosphates; Phosphatidic Acids; Phosphorylation; Platelet Aggregation Inhibitors; Precipitin Tests; Serotonin; Signal Transduction; Staurosporine; Type C Phospholipases; Tyrosine | 1994 |
Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Activation; Humans; Male; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1994 |
Reactions of prostaglandin endoperoxide synthase and its compound I with hydroperoxides.
Topics: Animals; Arachidonic Acid; Benzoates; Coumaric Acids; Cyclooxygenase Inhibitors; Horseradish Peroxidase; Kinetics; Male; Peroxides; Prostaglandins G; Seminal Vesicles; Sheep; Tyrosine | 1996 |
Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Arginine; Base Sequence; Binding Sites; Cyclooxygenase Inhibitors; DNA Primers; Enzyme Inhibitors; Flurbiprofen; Glutamates; Ibuprofen; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Protein Structure, Tertiary; Sheep; Structure-Activity Relationship; Tyrosine | 1996 |
Arachidonic acid stimulates protein tyrosine phosphorylation in vascular cells.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Endothelium, Vascular; Fatty Acids, Unsaturated; Muscle, Smooth, Vascular; Phosphorylation; Swine; Tyrosine | 1995 |
Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Brain; Cattle; Cytosol; Enzyme Activation; Humans; Hydrolysis; In Vitro Techniques; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipase C gamma; Phospholipases A; Phospholipases A2; Phosphorylation; Substrate Specificity; tau Proteins; Type C Phospholipases; Tyrosine | 1996 |
The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fc gamma receptor activation: study of the signaling mechanism.
Topics: Animals; Antigen-Antibody Complex; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Base Sequence; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Intercellular Signaling Peptides and Proteins; Macrophages, Peritoneal; Male; Molecular Sequence Data; Phosphorylation; Rats; Rats, Wistar; Receptors, IgG; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Genistein; Humans; Immunoblotting; Isoflavones; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Weight; Myelin Basic Protein; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Tyrosine | 1995 |
Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase 2; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Humans; Hydrogen Peroxide; Isoenzymes; Kinetics; Lipoxygenase; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Stereoisomerism; Tetranitromethane; Tyrosine | 1997 |
A role for tyrosine phosphorylation in generation of inositol phosphates and prostacyclin production in endothelial cells.
Topics: Arachidonic Acid; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Histamine; Humans; Inositol Phosphates; Isoenzymes; Phosphorylation; Protein Kinase Inhibitors; Thrombin; Type C Phospholipases; Tyrosine; Vanadates | 1997 |
Effects of intracellular tyrosine residue mutation and carboxyl terminus truncation on signal transduction and internalization of the rat bradykinin B2 receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Bradykinin; Conserved Sequence; Endocytosis; Inositol Phosphates; Kinetics; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Rats; Receptor, Bradykinin B2; Receptors, Bradykinin; Recombinant Proteins; Sequence Deletion; Signal Transduction; Tyrosine | 1997 |
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
Topics: Animals; Arachidonic Acid; Bleeding Time; Collagen; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mice; Mice, Inbred C57BL; Phenotype; Phospholipase C gamma; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Count; Protein-Tyrosine Kinases; Receptors, IgG; Serotonin; Signal Transduction; Syk Kinase; Thrombin; Type C Phospholipases; Tyrosine | 1997 |
Nitric oxide trapping of the tyrosyl radical of prostaglandin H synthase-2 leads to tyrosine iminoxyl radical and nitrotyrosine formation.
Topics: Arachidonic Acid; Blotting, Western; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrazines; Mutagens; Nitrates; Nitric Oxide; Nitrogen Oxides; Prostaglandin-Endoperoxide Synthases; Superoxide Dismutase; Tyrosine | 1997 |
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Genistein; Indomethacin; Isoflavones; Male; Naphthalenes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Polyenes; Rabbits; Staurosporine; Type C Phospholipases; Tyrosine | 1997 |
The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Genes, Tumor Suppressor; Linoleic Acids; Lipid Peroxides; Mesocricetus; Phenotype; Phosphorylation; Signal Transduction; Tyrosine | 1997 |
Stoichiometry of the interaction of prostaglandin H synthase with substrates.
Topics: Animals; Arachidonic Acid; Catalysis; Cattle; Chlorobenzoates; Computer Simulation; Electrochemistry; Electron Spin Resonance Spectroscopy; Free Radicals; Indicators and Reagents; Isoenzymes; Kinetics; Male; Models, Chemical; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Tyrosine | 1997 |
Selective inhibition of collagen-induced arachidonic acid liberation by 1-(5-iodonaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), a myosin light chain kinase inhibitor, in washed rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcium; Collagen; Enzyme Inhibitors; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Platelet Aggregation; Rabbits; Tyrosine | 1997 |
Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX.
Topics: Arachidonic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Isoenzymes; Leukotrienes; Lipid Peroxides; Molecular Conformation; Mutation; Oxygen; Peroxidases; Peroxides; Prostaglandin-Endoperoxide Synthases; Protoporphyrins; Tyrosine | 1998 |
The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation.
Topics: Allosteric Regulation; Arachidonic Acid; Binding Sites; Catalysis; Cyclooxygenase Inhibitors; Enzyme Activation; Hydrogen Bonding; Indomethacin; Kinetics; Models, Molecular; Molecular Structure; Oxygen; Prostaglandin-Endoperoxide Synthases; Thermodynamics; Tyrosine | 1998 |
[Effect of zooxanthellatoxin-A, an unique marine product, on arachidonic acid cascade in rabbit platelets].
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Eukaryota; Phosphorylation; Platelet Aggregation; Polyenes; Protein Kinase C; Rabbits; Tyrosine | 1997 |
Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Genistein; Pertussis Toxin; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin; Thyroid Gland; Tyrosine; Vanadates; Virulence Factors, Bordetella | 1998 |
Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385.
Topics: Amino Acid Sequence; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radicals; Indomethacin; Isoenzymes; Models, Chemical; Molecular Sequence Data; Nitric Oxide; Peptide Fragments; Peptide Mapping; Prostaglandin-Endoperoxide Synthases; Tetranitromethane; Tyrosine | 1998 |
Lipopolysaccharide induction of monocyte matrix metalloproteinases is regulated by the tyrosine phosphorylation of cytosolic phospholipase A2.
Topics: Arachidonic Acid; Benzoquinones; Collagenases; Cytosol; Dinoprostone; Enzyme Inhibitors; Humans; Lactams, Macrocyclic; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Monocytes; Phospholipases A; Phospholipases A2; Phosphorylation; Quinones; Rifabutin; Signal Transduction; Tyrosine | 1998 |
Motif mutation of bradykinin B2 receptor second intracellular loop and proximal C terminus is critical for signal transduction, internalization, and resensitization.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cell Line; Endocytosis; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Conformation; Rats; Receptor, Bradykinin B2; Receptors, Bradykinin; Signal Transduction; Tyrosine | 1998 |
Basic secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and phosphatidylinositol 3-kinase-dependent mechanism.
Topics: Androstadienes; Animals; Arachidonic Acid; Mast Cells; p-Methoxy-N-methylphenethylamine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Rats; Tyrosine; Wortmannin | 1998 |
Arachidonate-induced tyrosine phosphorylation of epidermal growth factor receptor and Shc-Grb2-Sos association.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Cells, Cultured; ErbB Receptors; GRB2 Adaptor Protein; Male; Membrane Proteins; Phosphorylation; Precipitin Tests; Proteins; Rabbits; Second Messenger Systems; Shc Signaling Adaptor Proteins; Son of Sevenless Proteins; Tyrosine | 1998 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Correlation between the in vivo efficacy of GPIIb/IIIa receptor antagonists (m7E3, MK-383 and DMP-728) and ex vivo platelet inhibition.
Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Arachidonic Acid; Bleeding Time; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Carotid Artery Thrombosis; Citrates; Dogs; Dose-Response Relationship, Drug; Female; Heparin; Immunoglobulin Fab Fragments; Male; Mesylates; Mice; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Tirofiban; Treatment Outcome; Tyrosine | 1999 |
AHNAK, a protein that binds and activates phospholipase C-gamma1 in the presence of arachidonic acid.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cattle; Chromosomes, Human, Pair 11; Enzyme Activation; HeLa Cells; Humans; Isoenzymes; Kinetics; Membrane Proteins; Molecular Sequence Data; Neoplasm Proteins; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Binding; tau Proteins; Type C Phospholipases; Tyrosine | 1999 |
Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Arachidonic Acid; Blood Platelets; Calcium; Cyclic AMP; Drugs, Chinese Herbal; Humans; Lanosterol; Phosphorylation; Platelet Aggregation; Reishi; Signal Transduction; Thromboxane A2; Tyrosine; Vasoconstrictor Agents | 1999 |
Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells.
Topics: Antioxidants; Arachidonic Acid; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Cholesterol, VLDL; Endothelium, Vascular; Enzyme Inhibitors; Estrenes; Fibrinolysis; Flavonoids; Gallic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase C; Pyrrolidinones; Signal Transduction; Thapsigargin; Tritium; Tumor Cells, Cultured; Tyrosine | 1999 |
Platelet glycoprotein IIb/IIIa blockade with tirofiban: effect on aggregation caused by P256, an antibody to human IIb/IIIa receptors.
Topics: Abciximab; Antibodies, Blocking; Antibodies, Monoclonal; Arachidonic Acid; Female; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Tirofiban; Tyrosine | 1999 |
Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complex.
Topics: Antigens, Differentiation; Arachidonic Acid; Binding Sites; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Copper; EF Hand Motifs; Humans; Magnesium; Neutrophils; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; S100 Proteins; Tryptophan; Tyrosine; Zinc | 1999 |
Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells.
Topics: Animals; Arachidonic Acid; Carcinoma, Squamous Cell; Cell Division; Cell Line; Chlorocebus aethiops; Dinoprostone; Esophageal Neoplasms; Fatty Acids, Unsaturated; Flow Cytometry; gamma-Linolenic Acid; Humans; Kidney; Phosphorylation; Prostaglandins A; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrosine | 1999 |
Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis.
Topics: Animals; Arachidonic Acid; Binding Sites; Cyclooxygenase 2; Electron Transport; Enzyme Activation; Heme; Histidine; Iron; Isoenzymes; Kinetics; Mutation; Oxidation-Reduction; Oxygen Consumption; Peroxidases; Peroxides; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Spectrophotometry; Tyrosine | 2000 |
Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arsenicals; Enzyme Inhibitors; Female; Naphthalenes; Phospholipases A; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Staurosporine; Tetramisole; Tyrosine | 2000 |
[Ca(2+)-signaling in peritoneal macrophages].
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Endoplasmic Reticulum; Enzyme Inhibitors; In Vitro Techniques; Indoles; Macrophages, Peritoneal; Mitochondria; Phosphorylation; Protein Kinase C; Purinergic Agonists; Rats; Thapsigargin; Tyrosine; Uridine Triphosphate | 2000 |
Adrenaline potentiates type 2B von Willebrand factor-induced activation of human platelets by enhancing both the formation and action of thromboxanes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Drug Synergism; Epinephrine; Humans; Kinetics; Lipoxygenase; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostanoic Acids; Serotonin; Sympathomimetics; Thromboxanes; Tyrosine; Vasoconstrictor Agents; von Willebrand Factor; Yohimbine | 2000 |
Effect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil.
Topics: Arachidonic Acid; Blood Proteins; Flavonoids; Humans; In Vitro Techniques; Luteolin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Quercetin; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
Ceramide accelerates dephosphorylation of extracellular signal-regulated kinase 1/2 to decrease prostaglandin D(2) production in RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Cell Line; Ceramides; Dose-Response Relationship, Drug; Immunoblotting; Mast Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phospholipase D; Phospholipases A; Phosphorylation; Prostaglandin D2; Protein Tyrosine Phosphatases; Rats; Tumor Cells, Cultured; Tyrosine; Vanadates | 2001 |
Preconditioning of 3T3 cells by fresh medium together with genistein enhances prostaglandin E(2) release.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Genistein; Immunoblotting; Isoenzymes; Membrane Proteins; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Tyrosine | 2001 |
Hyperosmotic stress induces phosphorylation of cytosolic phospholipase A(2) in HaCaT cells by an epidermal growth factor receptor-mediated process.
Topics: Arachidonic Acid; Calcium; Cell Compartmentation; Cell Line, Transformed; Cell Nucleus; Dinoprostone; Drug Eruptions; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipids; Phosphorylation; Phosphotransferases; Protein Serine-Threonine Kinases; Sorbitol; Stress, Physiological; Tyrosine | 2002 |
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide; Isoenzymes; Magnetics; Membrane Proteins; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Sheep; Tyrosine | 2002 |
Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.
Topics: Anemone; Arachidonic Acid; Betulinic Acid; Hemolysis; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentacyclic Triterpenes; Phosphorylation; Proteins; Superoxides; Triterpenes; Tyrosine | 2002 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
Effect of S-(1,2-dicarboxyethyl) glutathione and S-(1,2-dicarboxyethyl) cysteine on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.
Topics: Arachidonic Acid; Blood Proteins; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Glutathione; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells.
Topics: Antioxidants; Arachidonic Acid; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cysteine Endopeptidases; Cytochrome P-450 CYP2E1; Drug Synergism; Endopeptidases; Humans; Iron; Leupeptins; Lipid Peroxides; Liver Neoplasms; Lysosomes; Membrane Potentials; Mitochondria, Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Tyrosine | 2003 |
Arachidonic acid regulates surface expression of epithelial sodium channels.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Amiloride; Amino Acid Motifs; Animals; Anisotropy; Arachidonic Acid; Biological Transport; Cell Membrane; DNA; Endocytosis; Epithelial Sodium Channels; Gene Expression Regulation; Mutation; Oocytes; Patch-Clamp Techniques; Phospholipases A; Phospholipases A2; Protein Structure, Tertiary; Sodium; Sodium Channels; Spectrometry, Fluorescence; Time Factors; Tyrosine; Xenopus laevis | 2003 |
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arginine; Binding, Competitive; Cell Line; Crystallography, X-Ray; Cyclooxygenase 2; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insecta; Isoenzymes; Mice; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Piroxicam; Prostaglandin-Endoperoxide Synthases; Protein Binding; Serine; Sulfonamides; Time Factors; Tyrosine | 2003 |
Effect of three triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation and tyrosyl phosphorylation and translocation of p47(phox) and p67(phox) to cell membrane in human neutrophil.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Humans; Immunoblotting; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; Plant Roots; Protein Transport; Saponins; Superoxides; Tetradecanoylphorbol Acetate; Triterpenes; Tyrosine | 2003 |
AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.
Topics: Animals; Arachidonic Acid; Blotting, Western; Bradykinin; Calcium; COS Cells; Enzyme Activation; Gene Library; Glutathione Transferase; Humans; Inositol Phosphates; Isoenzymes; Membrane Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Neoplasm Proteins; NIH 3T3 Cells; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Serine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Type C Phospholipases; Tyrosine | 2004 |
Downregulation of nitric oxide formation by cytosolic phospholipase A2-released arachidonic acid.
Topics: Animals; Arachidonic Acid; Cell Line, Tumor; Cytosol; Down-Regulation; Immunohistochemistry; Lipoxygenase; Mice; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Rats; Superoxides; Tyrosine | 2004 |
Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Eicosanoids; Male; Mesenteric Arteries; Nitrogen; Obesity; Potassium Channels; Rats; Rats, Zucker; RNA, Messenger; Tyrosine; Vasodilation | 2005 |
Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells.
Topics: 8,11,14-Eicosatrienoic Acid; Adaptor Proteins, Signal Transducing; Animals; Arachidonic Acid; Calcium; Cell Degranulation; Cell Membrane; Cells, Cultured; Cytokines; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Intracellular Signaling Peptides and Proteins; Mast Cells; Membrane Proteins; Palmitic Acid; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Reactive Oxygen Species; Receptors, IgE; Signal Transduction; Syk Kinase; Tyrosine | 2005 |
Effect of five triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of p47(phox), p67(phox), and rac to cell membrane in human neutrophils.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Cells, Cultured; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; rac GTP-Binding Proteins; Serine; Superoxides; Tetradecanoylphorbol Acetate; Threonine; Triterpenes; Tyrosine | 2006 |
Effect of inhibition of nitric oxide synthase on renal cyclooxygenase in the diabetic rat.
Topics: Angiotensin II; Animals; Arachidonic Acid; Blood Pressure; Blotting, Western; Body Weight; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Perfusion; Pressure; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 2006 |
Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.
Topics: Aldehyde Reductase; Animals; Antioxidants; Arachidonic Acid; Benzothiazoles; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Hydroxyeicosatetraenoic Acids; Hypoglycemic Agents; Indomethacin; Insulin; Kidney; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Perfusion; Phthalazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Spin Labels; Tyrosine | 2008 |
Attenuated PGI2 synthesis in obese Zucker rats.
Topics: Animals; Arachidonic Acid; Blotting, Western; Cell Separation; Epoprostenol; Fluorescent Antibody Technique; In Vitro Techniques; Male; Microcirculation; Myocytes, Smooth Muscle; Nitrates; Obesity; Physical Conditioning, Animal; Rats; Rats, Zucker; Receptors, Epoprostenol; Receptors, Thromboxane A2, Prostaglandin H2; Tyrosine | 2009 |
C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.
Topics: Animals; Arachidonic Acid; Arterioles; C-Reactive Protein; Cell Separation; Cytochrome P-450 Enzyme System; Enzyme Activation; Epoprostenol; Immunohistochemistry; Intramolecular Oxidoreductases; Nitric Oxide; Nitroprusside; Peroxynitrous Acid; Serotonin; Sus scrofa; Tyrosine; Vasodilation; Vasomotor System | 2009 |
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.
Topics: Arachidonic Acid; Catalysis; Cyclooxygenase 1; Cyclooxygenase 2; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide; Kinetics; Mutation; Tyrosine | 2009 |
Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Catalytic Domain; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Electrochemistry; Enzyme Activation; Heme; Humans; Mice; Molecular Sequence Data; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Rats; Stress, Physiological; Substrate Specificity; Tandem Mass Spectrometry; Tyrosine | 2010 |
Arachidonic acid inhibits neuronal nitric oxide synthase elicited by proinflammatory stimuli and promotes astrocyte survival with both exogenous and endogenous peroxynitrite via different mechanisms.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Immunohistochemistry; Inflammation; Lipoxygenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2010 |
Treatment of diabetic rats with a peroxynitrite decomposition catalyst prevents induction of renal COX-2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Cells, Cultured; Creatinine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Experimental; Dinoprostone; Humans; Kidney; Male; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.
Topics: Arachidonic Acid; Biocatalysis; Deuterium; Electron Spin Resonance Spectroscopy; Free Radicals; Isotope Labeling; Kinetics; Oxygen; Prostaglandin-Endoperoxide Synthases; Substrate Specificity; Tyrosine | 2011 |
Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2.
Topics: Alkadienes; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Oxygen; Peroxides; Substrate Specificity; Tyrosine | 2011 |
Conformational effects on the pro-S hydrogen abstraction reaction in cyclooxygenase-1: an integrated QM/MM and MD study.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cyclooxygenase 1; Humans; Hydrogen; Mechanics; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Conformation; Quantum Theory; Tyrosine | 2013 |
Dissecting the potential mechanism of antihypertensive effects of RVPSL on spontaneously hypertensive rats via widely targeted kidney metabolomics.
Topics: 3-Hydroxybutyric Acid; Animals; Antihypertensive Agents; Arachidonic Acid; Biomarkers; Blood Pressure; Carbon; Citric Acid; Hypertension; Kidney; Metabolomics; Rats; Rats, Inbred SHR; Serine; Thyronines; Tyramine; Tyrosine | 2023 |