tyrosine has been researched along with alpha-synuclein in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 44 (46.81) | 29.6817 |
| 2010's | 37 (39.36) | 24.3611 |
| 2020's | 13 (13.83) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q; Giasson, BI; Ischiropoulos, H; Lee, VM; Souza, JM | 1 |
| Chen, Q; Duda, JE; Giasson, BI; Hurtig, HI; Ischiropoulos, H; Lee, VM; Murray, IV; Souza, JM; Trojanowski, JQ | 1 |
| Chen, Q; Duda, JE; Giasson, BI; Gollomp, SM; Gur, TL; Hurtig, HI; Ischiropoulos, H; Lee, VM; Stern, MB; Trojanowski, JQ | 1 |
| Nakamura, S; Nakamura, T; Takahashi, T; Yamashita, H | 1 |
| Halliwell, B; Hyun, D; Jenner, P; Lee, M | 1 |
| Chen, Q; Djaldatti, R; Giasson, BI; Ischiropoulos, H; Jackson-Lewis, V; Lee, VM; Przedborski, S; Souza, JM; Vila, M; Vukosavic, S | 1 |
| Boveris, AD; Cadenas, E; Poderoso, JJ; Riobó, NA; Schöpfer, FJ | 1 |
| Ahn, BH; Chang, JS; Choi, JY; Chung, KC; Hahn, SJ; Jo, YH; Kim, MS; Kim, SY; Kwon, TK; Lee, MY; Lee, YH; Min, DS; Rhim, H; Sung, YM; Wolozin, B; Yoon, SH | 1 |
| García Yébenes, J; Gómez-Tortosa, E; Gonzalo, I; Hyman, BT; Newell, K; Vonsattel, P | 1 |
| Nagano, Y; Nakamura, S; Nakamura, T; Takahashi, T; Yamashita, H | 1 |
| Avraham, H; Avraham, S; Matsumoto, M; Nagano, Y; Nakamura, S; Nakamura, T; Takahashi, T; Yamashita, H | 1 |
| Drazba, J; Gaivin, R; Gonzalez-Cabrera, P; McCune, DF; Papay, R; Perez, DM; Ross, SA; Yun, J; Zuscik, MJ | 1 |
| Biere, AL; Carpenter, JF; Chi, EY; Citron, M; Garzon-Rodriguez, W; Kendrick, BS; Krishnan, S; Li, C; Narhi, LO; Randolph, TW; Wood, SJ; Wypych, J | 1 |
| Kang, JH; Kim, KS | 1 |
| Fink, AL; Uversky, VN; Yamin, G | 1 |
| Giasson, BI; Ischiropoulos, H; Lee, VM; Norris, EH | 1 |
| Andrekopoulos, C; Joseph, J; Kalivendi, S; Kalyanaraman, B; Zhang, H | 1 |
| Freed, CR; Zhou, W | 1 |
| Bennett, JP; Borland, MK; Keeney, PM; Parker, WD; Trimmer, PA | 1 |
| Fink, AL; Han, S; Kaylor, J; Rajamani, S; Zhou, F; Zhu, M | 1 |
| Darabie, AA; Fraser, PE; Han, K; Jo, E; McLaurin, J; Tandon, A | 1 |
| Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Lynch, DR; Mishizen-Eberz, AJ; Norris, EH | 1 |
| Olteanu, A; Pielak, GJ | 1 |
| Doniach, S; Fink, AL; Karymov, MA; Lyubchenko, YL; Millett, IS; Munishkina, LA; Uversky, VN; Yamin, G | 1 |
| Cribb, AE; Donaldson, MT; Dybdal, N; McFarlane, D; Miller, L | 1 |
| Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Norris, EH; Trojanowski, JQ; Xu, S | 1 |
| Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Lynch, DR; Mishizen-Eberz, AJ; Norris, EH; Trojanowski, JQ | 1 |
| Akaike, A; Hayashi, K; Inden, M; Kitamura, Y; Kondo, J; Nishimura, K; Shimohama, S; Sugimoto, H; Takata, K; Taniguchi, T; Tsuchiya, D; Yanagida, T; Yanagisawa, D | 1 |
| Bodner, N; Edridge, S; Fink, AL; Hong, DP; Kaylor, J; Yamin, G | 1 |
| Champy, P; Duyckaerts, C; Féger, J; Hirsch, EC; Höglinger, GU; Khondiker, ME; Lannuzel, A; Lombes, A; Medja, F; Michel, PP; Oertel, WH; Prigent, A; Ruberg, M | 1 |
| Bodner, N; Dusa, A; Edridge, S; Fink, AL; Hong, DP; Kaylor, J | 1 |
| Dalfó, E; Ferrer, I; Martinez, A; Muntané, G | 1 |
| Rubbo, H; Trostchansky, A | 1 |
| Gray, HB; Kozak, JJ; Lai, BT; Lee, JC; Winkler, JR | 1 |
| Bergantino, E; Bisaglia, M; Bubacco, L; Mammi, S; Samorì, B; Tessari, I; Valle, F | 1 |
| Rao, KS | 1 |
| Barry, CH; Fink, AL; Ulrih, NP | 1 |
| Emmanouilidou, E; Stefanis, L; Vekrellis, K | 1 |
| Lutz, EA; Pielak, GJ; Ruf, RA; Zigoneanu, IG | 1 |
| Behr, GA; da Rocha, RF; de Oliveira, MR; Hoff, ML; Moreira, JC; Oliveira, MW | 1 |
| Da Rocha, RF; De Oliveira, MR; Moreira, JC; Oliveira, MW | 1 |
| Fink, AL; Meng, X; Munishkina, LA; Uversky, VN | 1 |
| Li, C; Lutz, EA; Pielak, GJ; Ruf, RA; Slade, KM; Wang, GF | 1 |
| Andersen, JK; Danielson, SR; Gibson, BW; Held, JM; Oo, M; Schilling, B | 1 |
| Chen, L; Feany, MB; Hyman, BT; McLean, PJ; Negro, A; Periquet, M; Wang, X | 1 |
| Bing, G; Cass, WA; Choi, DY; Gash, DM; Hunter, RL; Kim, HC; Liu, M; Pandya, JD; Sullivan, PG | 1 |
| Graham, DR; Sidhu, A | 1 |
| He, R; Liu, Y | 1 |
| Alerte, TN; Daubner, SC; Di Monte, DA; Friedrich, EE; Hong, CS; Lou, H; Mader, SA; Marcus, BS; McCormack, AL; Montoya, SE; Pedersen, CJ; Peng, X; Perez, RG; Wang, J; Wu, J | 1 |
| Andreoni, S; Begni, B; Brighina, L; Difrancesco, JC; Ferrarese, C; Galbussera, A; Piazza, F; Piolti, R; Prigione, A | 1 |
| Gabryelak, T; Malachowska, M; Milowska, K | 1 |
| Fantini, J; Yahi, N | 1 |
| Dunn, JM; Rhoades, E; Sevcsik, E; Trexler, AJ | 1 |
| da Rocha, RF; de Oliveira, MR; Moreira, JC; Schnorr, CE | 1 |
| He, R; Liu, Y; Qiang, M; Wei, Y | 1 |
| Daian, D; Dodiya, HB; Jaglin, JA; Keshavarzian, A; Kordower, JH; Mutlu, E; Shannon, KM | 1 |
| Dodiya, HB; Estes, JD; Forsyth, CB; Jaglin, JA; Keshavarzian, A; Kordower, JH; Shaikh, M; Shannon, KM; Voigt, RM | 1 |
| Butterfield, S; Cui, J; Dikiy, I; Eliezer, D; Fauvet, B; Hejjaoui, M; Lashuel, HA; Olschewski, D; Prudent, M; Vercruysse, F; Zhang, Y | 1 |
| Cernocká, H; Kurzątkowska, K; Ostatná, V; Paleček, E | 1 |
| Engelborghs, Y; Kluba, M; Meuvis, J; Schreurs, S | 1 |
| Borsarelli, CD; Falomir-Lockhart, LJ; Fauerbach, JA; Hsiao, HH; Jares-Erijman, EA; Jovin, TM; Ostatná, V; Paleček, E; Urlaub, H | 1 |
| Choi, HS; Jang, A; Kim, YM; Lashuel, H; Liew, H; Suh, YH | 1 |
| Fauvet, B; Girault, HH; Lashuel, HA; Lu, Y; Prudent, M | 1 |
| Chacón, J; Fernández, E; García-Moreno, JM; Martín de Pablos, A | 1 |
| Bhat, R; Jain, MK | 1 |
| Dyrnesli, H; Ferapontova, EE; Lopes, P; Lorenzen, N; Otzen, D | 1 |
| Cai, Z; Chen, LL; Chua, KK; Li, M; Liu, LF; Luan, H; Meng, N; Mok, VC; Song, JX; Tang, Z; Xie, LX | 1 |
| Bekei, B; Binolfi, A; Kosten, J; Selenko, P; Stuiver, M; Theillet, FX; van Rossum, M; Verzini, S | 1 |
| Pirc, K; Pogačnik, L; Poklar-Ulrih, N; Škarabot, M; Žerovnik, E | 1 |
| Jorge, CD; Maçanita, AL; Santos, H; Saraiva, MA | 1 |
| Brichtová, E; Niederhafner, P; Šafařík, M; Šebestík, J | 1 |
| Chen, M; Du, T; Duan, C; Gao, G; Liu, J; Wang, Y; Yang, H | 1 |
| Braus, GH; Kleinknecht, A; Lázaro, DF; Outeiro, TF; Pinho, R; Popova, B; Valerius, O | 1 |
| Dempsey, RJ; Kaimal, B; Kim, T; Lyons, K; Mehta, SL; Vemuganti, R | 1 |
| Abdul-Sada, A; Al-Hilaly, YK; Biasetti, L; Blakeman, BJ; Pollack, SJ; Serpell, LC; Thorpe, JR; Xue, WF; Zibaee, S | 1 |
| Buell, AK; Gremer, L; Groß, L; Hoyer, W; Shaykhalishahi, H; Stoldt, M; Willbold, D; Wördehoff, MM | 1 |
| Chiki, A; De Genst, E; Di Trani, J; Dobson, CM; El Turk, F; Fauvet, B; Guilliams, T; Hejjaoui, M; Lashuel, HA; Mittermaier, A; Vendruscolo, M | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R | 1 |
| Daiber, A; Delp, J; Gerding, HR; Hammler, D; Karreman, C; Leist, M; Mex, M; Schildknecht, S | 1 |
| Abou-Zied, OK; Akhtari, K; Aziz, FM; Falahati, M; Mustafa, TA; Salihi, A; Shahpasand, K; Tahaei Gilan, SS; Yahya Rayat, D | 1 |
| Abeyawardhane, DL; Curry, AM; Forney, AK; Lucas, HR; Roberts, JW | 1 |
| Abdesselem, H; Attems, J; El-Agnaf, OMA; Erskine, D; Fayyad, M; Ghanem, SS; Lamprokostopoulou, A; Majbour, NK; Morris, CM; Sudhakaran, IP; Vaikath, NN; Vekrellis, K | 1 |
| Buratti, FA; Carloni, P; Fernandez, CO; Palomino-Hernandez, O; Rossetti, G; Sacco, PS | 1 |
| Belsom, A; Bieschke, J; Binolfi, A; Rappsilber, J; Selenko, P; Shah, M; Theillet, FX; Verzini, S; Wanker, EE | 1 |
| Eliezer, D; Pan, B; Park, JH; Petersson, EJ; Ramlall, T; Rhoades, E | 1 |
| Hegemann, JD; Liu, L; Long, T; Quan, J; Tao, Y; Tian, H; Uesugi, M; Wang, H; Yao, W; Zhang, W; Zheng, J | 1 |
| Choudhary, S; Hosur, RV; Paithankar, H; Rane, AR | 1 |
| Bahri, MA; Becker, G; Bezard, E; Caruso, M; Citron, M; De Wolf, C; Deprez, T; Downey, P; Frequin, JM; Freyssin, A; Garraux, G; Gillent, E; Hustadt, F; Jacquin, L; Lemaire, C; Luxen, A; Mairet-Coello, G; Michel, A; Plenevaux, A | 1 |
| Hosokawa, M; Irie, K; Iwasaki, Y; Mishima, K; Sano, K; Satoh, K; Yamashita, Y | 1 |
| Medvedeva, MV; Muronetz, VI; Pozdyshev, DV; Sevostyanova, IA | 1 |
| Amstrup, SK; Bjerrum, MJ; Christiansen, G; Costeira-Paulo, J; Davies, MJ; Grønnemose, AL; Ilag, LL; Jørgensen, TJD; Landreh, M; Marklund, EG; Møller, IM; Nielsen, J; Österlund, N; Otzen, DE; Pedersen, JN; Pedersen, JS; Rao, RSP; Sahin, C; Tiwari, MK; Østerlund, EC | 1 |
| Al-Hilaly, YK; Biasetti, L; Burra, G; Harrington, CR; Khanom, T; Maina, MB; Marshall, K; Mengham, K; Oakley, S; Serpell, LC; Wischik, CM | 1 |
| Ayaki, T; Chiba, S; Hirai, H; Hirotsune, S; Ishida, R; Jin, M; Komai, S; Konno, A; Matsumoto, S; Nakajima, H; Taguchi, T; Takahashi, R; Takao, T; Togawa, N; Yamakado, H | 1 |
| Basso, E; Füchtbauer, A; Füchtbauer, EM; Jensen, PH; Lassen, LB; Moos, T; Outeiro, TF; Thomsen, MS | 1 |
2 review(s) available for tyrosine and alpha-synuclein
| Article | Year |
|---|---|
Lipid nitration and formation of lipid-protein adducts: biological insights.
Topics: alpha-Synuclein; Humans; Lipid Metabolism; Lipids; Lipoproteins, LDL; Nitrates; Oxidative Stress; Proteins; Reactive Nitrogen Species; Tyrosine | 2007 |
Potential Effect of Post-Transcriptional Substitutions of Tyrosine for Cysteine Residues on Transformation of Amyloidogenic Proteins.
Topics: alpha-Synuclein; Amyloidogenic Proteins; Codon; Cysteine; Escherichia coli; Humans; Tyrosine | 2022 |
92 other study(ies) available for tyrosine and alpha-synuclein
| Article | Year |
|---|---|
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
Topics: alpha-Synuclein; Electrophoresis, Polyacrylamide Gel; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitrates; Oxidative Stress; Polymers; Recombinant Proteins; Synucleins; Tyrosine | 2000 |
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
Topics: alpha-Synuclein; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Lewy Bodies; Lewy Body Disease; Microscopy, Immunoelectron; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidative Stress; Parkinson Disease; Synucleins; Tyrosine | 2000 |
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Antibodies; Blotting, Western; Brain Diseases; Female; Humans; Immunohistochemistry; Inclusion Bodies; Lewy Bodies; Male; Middle Aged; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglia; Nitrates; Synucleins; Tissue Distribution; Tyrosine | 2000 |
Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.
Topics: alpha-Synuclein; Animals; Blotting, Northern; Brain; Central Nervous System; COS Cells; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA Mutational Analysis; DNA, Complementary; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Neurons; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Synucleins; Time Factors; Tissue Distribution; Tyrosine | 2001 |
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.
Topics: 1-Methyl-4-phenylpyridinium; Aldehydes; alpha-Synuclein; Cell Division; Cell Line; Cell Survival; Clone Cells; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression; Glutathione; Guanine; Humans; Hydrogen Peroxide; Ketones; Lipid Peroxidation; Mitochondria; Mutation; Nerve Tissue Proteins; Neuroblastoma; Oxidants; Oxidative Stress; Parkinsonian Disorders; Synucleins; Teratocarcinoma; Transfection; Tyrosine | 2001 |
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; beta-Synuclein; Cell Line; Corpus Striatum; Disease Models, Animal; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Oxidation-Reduction; Parkinsonian Disorders; Peroxynitrous Acid; Precipitin Tests; Protein Processing, Post-Translational; Synaptophysin; Synucleins; Transfection; Tyrosine | 2001 |
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cattle; Nerve Tissue Proteins; Nitric Oxide; Oxidation-Reduction; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxide Dismutase; Synucleins; Tyrosine | 2002 |
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells.
Topics: alpha-Synuclein; Animals; Blood Proteins; Blotting, Western; Brain; Cell Line; Cytoplasm; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Glutathione Transferase; Humans; Microscopy, Fluorescence; Mutation; Nerve Tissue Proteins; Phospholipase D; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Synucleins; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tyrosine; Vanadates | 2002 |
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.
Topics: Aged; alpha-Synuclein; Brain; Cell Nucleus; Female; Humans; Inclusion Bodies; Lewy Bodies; Lewy Body Disease; Male; Middle Aged; Nerve Tissue Proteins; Neurites; Neuroglia; Neurons; Nitrates; Oxidative Stress; Striatonigral Degeneration; Synucleins; Tyrosine | 2002 |
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.
Topics: alpha-Synuclein; Dimerization; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; In Vitro Techniques; Microscopy, Confocal; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Synucleins; Tyrosine | 2002 |
Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases.
Topics: alpha-Synuclein; Animals; Chlorocebus aethiops; COS Cells; Enzyme Activation; Focal Adhesion Kinase 2; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Synucleins; Tyrosine | 2002 |
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.
Topics: Adrenergic alpha-Antagonists; alpha-Synuclein; Animals; Body Weight; Brain; Cerebellum; Disease Models, Animal; Female; Inclusion Bodies; Macromolecular Substances; Male; Mice; Mice, Transgenic; Motor Activity; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nitrates; Oligodendroglia; Phosphorylation; Prazosin; Receptors, Adrenergic, alpha-1; Spinal Cord; Survival Rate; Synucleins; Tyrosine; Ubiquitin | 2002 |
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.
Topics: alpha-Synuclein; Amino Acid Substitution; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dimerization; Humans; Hydrogen-Ion Concentration; Light; Nerve Tissue Proteins; Osmolar Concentration; Osmotic Pressure; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Isoforms; Scattering, Radiation; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Synucleins; Temperature; Tyrosine | 2003 |
Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.
Topics: alpha-Synuclein; Amino Acid Substitution; Anserine; Antioxidants; Antiparkinson Agents; Biopolymers; Carnosine; Chelating Agents; Codon; Copper; Edetic Acid; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Isopropyl Thiogalactoside; Lewy Bodies; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Phenylmethylsulfonyl Fluoride; Point Mutation; Resins, Synthetic; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tyrosine | 2003 |
Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers.
Topics: alpha-Synuclein; Humans; Kinetics; Nerve Tissue Proteins; Parkinson Disease; Solubility; Synucleins; Tetranitromethane; Tyrosine | 2003 |
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.
Topics: alpha-Synuclein; Cell Line; Cross-Linking Reagents; Drug Stability; Humans; In Vitro Techniques; Inclusion Bodies; Microscopy, Electron; Models, Biological; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Nitrates; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Protein Structure, Quaternary; Recombinant Proteins; Synucleins; Tyrosine | 2003 |
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical.
Topics: alpha-Synuclein; Anions; Bicarbonates; Cyclic N-Oxides; Dimerization; Free Radicals; Hydrogen Peroxide; Hydroxylation; Liposomes; Nerve Tissue Proteins; Nitric Oxide Donors; Nitrogen Dioxide; Nitrogen Oxides; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tyrosine | 2004 |
Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity.
Topics: Adenoviridae; alpha-Synuclein; Animals; Apoptosis; beta-Synuclein; Blotting, Western; Cell Line; Cell Survival; Cloning, Molecular; Cysteine; Detergents; Dimerization; Electrophoresis, Polyacrylamide Gel; Humans; Immunohistochemistry; Magnetic Resonance Spectroscopy; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Neurons; Nitrogen; Octoxynol; Oxidative Stress; Oxygen; Phenylalanine; Plasmids; Protein Binding; Proteins; Rats; Recombinant Proteins; Synucleins; Time Factors; Transfection; Tyrosine | 2004 |
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.
Topics: Aged; alpha-Synuclein; Blotting, Western; Carrier Proteins; Case-Control Studies; Cell Line; Cysteine Endopeptidases; Cytochromes c; DNA, Mitochondrial; Electron Transport Complex I; Female; Humans; Immunohistochemistry; Lewy Bodies; Male; Microscopy, Confocal; Microscopy, Electron; Middle Aged; Multienzyme Complexes; Nerve Tissue Proteins; Neuroblastoma; Neurofilament Proteins; Neurons; Parkinson Disease; Precipitin Tests; Proteasome Endopeptidase Complex; Staining and Labeling; Synucleins; Transgenes; Tubulin; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils.
Topics: alpha-Synuclein; Anaerobiosis; Benzothiazoles; Circular Dichroism; Escherichia coli; Flavanones; Flavonoids; Humans; Light; Lysine; Microscopy, Atomic Force; Molecular Weight; Nerve Tissue Proteins; Oxidation-Reduction; Protein Conformation; Quinones; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Synucleins; Thiazoles; Tyrosine | 2004 |
alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis.
Topics: Alanine; alpha-Synuclein; Animals; Circular Dichroism; Dimerization; Fatty Acids; Humans; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Protein Binding; Protein Structure, Quaternary; Rats; Spectrometry, Fluorescence; Surface Properties; Synaptic Membranes; Synaptosomes; Synucleins; Tyrosine | 2004 |
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.
Topics: alpha-Synuclein; Animals; Calpain; Humans; Insulin; Lipid Metabolism; Mice; Molecular Chaperones; Nerve Tissue Proteins; Nitrates; Oxygen; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Quaternary; Synucleins; Tyrosine | 2004 |
Peroxidative aggregation of alpha-synuclein requires tyrosines.
Topics: alpha-Synuclein; Cytochromes c; Dimerization; Humans; Hydrogen Peroxide; Nerve Tissue Proteins; Oxidation-Reduction; Reactive Oxygen Species; Synucleins; Tyrosine | 2004 |
Effects of nitration on the structure and aggregation of alpha-synuclein.
Topics: alpha-Synuclein; Animals; Circular Dichroism; Dose-Response Relationship, Drug; Humans; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Models, Molecular; Nerve Tissue Proteins; Oxidants; Recombinant Proteins; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Stress Fibers; Synucleins; Tetranitromethane; Time Factors; Tyrosine | 2005 |
Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction.
Topics: alpha-Synuclein; Animals; Blotting, Western; Chronic Disease; Dopamine; Horse Diseases; Horses; Immunohistochemistry; Nerve Degeneration; Nerve Tissue Proteins; Nitrogen; Oxidative Stress; Pituitary ACTH Hypersecretion; Pituitary Gland; Synucleins; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.
Topics: alpha-Synuclein; Amino Acid Motifs; Circular Dichroism; DNA, Complementary; Dopamine; Histidine; Humans; Indolequinones; Methionine; Microscopy, Atomic Force; Microscopy, Electron; Mutagenesis; Mutation; Nerve Tissue Proteins; Oxidative Stress; Oxygen; Parkinson Disease; Peptides; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Synucleins; Time Factors; Tyrosine | 2005 |
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Parkinson Disease; Peptide Fragments; Peroxynitrous Acid; Recombinant Proteins; Solubility; Synucleins; Tyrosine | 2005 |
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.
Topics: Adrenergic Agents; Aldehydes; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; CD11b Antigen; Cell Count; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Functional Laterality; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Neurodegenerative Diseases; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Parkinsonian Disorders; Rats; Rats, Wistar; Reactive Oxygen Species; Rotarod Performance Test; Rotation; Substantia Nigra; Synaptophysin; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein.
Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Tryptophan; Tyrosine | 2005 |
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Benzothiazoles; Body Weight; Caspase 3; Caspases; Cell Death; Cerebral Cortex; Cytarabine; Diagnostic Imaging; Dopamine and cAMP-Regulated Phosphoprotein 32; Doxorubicin; Dystonia; Electron Transport Complex III; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Locomotion; Male; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Posture; Psychomotor Performance; Rats; Rats, Inbred Lew; Rotenone; tau Proteins; Tauopathies; Thiazoles; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin; Uncoupling Agents | 2005 |
Characterization of oligomers during alpha-synuclein aggregation using intrinsic tryptophan fluorescence.
Topics: Acrylamide; alpha-Synuclein; Amino Acid Substitution; Amyloid; Anilino Naphthalenesulfonates; Fluorescence; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; Protein Structure, Secondary; Solvents; Time Factors; Tryptophan; Tyrosine | 2006 |
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.
Topics: Aged; alpha-Synuclein; Blotting, Western; Case-Control Studies; Female; Frontal Lobe; Humans; Immunohistochemistry; Male; Molecular Weight; Parkinson Disease; Pick Disease of the Brain; Postmortem Changes; Tyrosine | 2006 |
Alpha-synuclein tertiary contact dynamics.
Topics: alpha-Synuclein; Amino Acid Sequence; Electron Transport; Molecular Sequence Data; Protein Conformation; Tryptophan; Tyrosine | 2007 |
The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.
Topics: alpha-Synuclein; Circular Dichroism; Cytosol; Dopamine; Humans; Models, Biological; Monophenol Monooxygenase; Mutation; Oxygen; Parkinson Disease; Quinones; Reactive Oxygen Species; Spectrophotometry, Ultraviolet; Time Factors; Tyrosine | 2008 |
Molecular understanding of copper and iron interaction with alpha-synuclein by fluorescence analysis.
Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Binding Sites; Copper; Fluorescence; Fluorescent Dyes; Humans; Iron; Protein Binding; Thiazoles; Tyrosine | 2008 |
Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties.
Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Amyloid; Circular Dichroism; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Mutation, Missense; Parkinson Disease; Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2008 |
Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome.
Topics: Alanine; alpha-Synuclein; Ammonium Chloride; Animals; Benzoquinones; Cerebral Cortex; Chromatography, Gel; Coloring Agents; Congo Red; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Humans; Immunoprecipitation; Lactams, Macrocyclic; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; PC12 Cells; Proteasome Endopeptidase Complex; Protein Folding; Rats; Transfection; Tyrosine | 2010 |
Alpha-Synuclein conformation affects its tyrosine-dependent oxidative aggregation.
Topics: alpha-Synuclein; Cytochromes c; Humans; Hydrogen Peroxide; Molecular Conformation; Mutation; Oxidative Stress; Oxygen; Parkinson Disease; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Recombinant Proteins; Tyrosine | 2008 |
Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: mitochondrial impairment, increased 3-nitrotyrosine and alpha-synuclein, but decreased D2 receptor contents.
Topics: alpha-Synuclein; Animals; Caspase 3; Dietary Supplements; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Energy Metabolism; Free Radical Scavengers; Glutathione Transferase; Indicators and Reagents; Mitochondria; Neostriatum; Oxidation-Reduction; Rats; Receptors, Dopamine D2; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine; Vitamin A; Vitamins | 2009 |
Vitamin A supplementation at pharmacological doses induces nitrosative stress on the hypothalamus of adult Wistar rats.
Topics: Administration, Oral; alpha-Synuclein; Animals; Brain; Caspase 3; Electron Transport Chain Complex Proteins; Hypothalamus; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Receptors, Dopamine D2; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vitamin A | 2009 |
Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation.
Topics: alpha-Synuclein; Animals; Binding Sites; Catalase; Cattle; Cyclic N-Oxides; Flavanones; Flavonoids; Free Radicals; Humans; Hydrogen Peroxide; Isoelectric Focusing; Mass Spectrometry; Mutation; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Stability; Time Factors; Tyrosine | 2009 |
19F NMR studies of alpha-synuclein conformation and fibrillation.
Topics: alpha-Synuclein; Buffers; Drug Combinations; Fluorine Radioisotopes; Fluorometry; Humans; Magnetic Resonance Spectroscopy; Molecular Weight; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Sodium Dodecyl Sulfate; Spectrometry, Mass, Electrospray Ionization; Spermine; Tyrosine | 2009 |
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Lewy Bodies; Mass Spectrometry; Models, Biological; Monoamine Oxidase; Nitrates; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Tyrosine | 2009 |
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Neurons; Parkinson Disease; Phosphorylation; Serine; Tyrosine | 2009 |
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.
Topics: alpha-Synuclein; Animals; Caspase 3; CD11b Antigen; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Electrochemistry; Encephalitis; Gene Expression Regulation; Male; Mitochondria; Neurodegenerative Diseases; Oxidative Stress; Rats; Rats, Inbred F344; Rotarod Performance Test; Solvents; Substantia Nigra; Trichloroethylene; Tyrosine; Tyrosine 3-Monooxygenase | 2010 |
Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.
Topics: Age Factors; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Anxiety; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Gene Expression Regulation; Humans; Hyperkinesis; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Mutation; Norepinephrine; Serotonin Plasma Membrane Transport Proteins; Tyrosine | 2010 |
Fasting induces a high level of 3-nitrotyrosine in the brain of rats.
Topics: alpha-Synuclein; Animals; Brain; Diabetes Mellitus, Experimental; Fasting; Male; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.
Topics: alpha-Synuclein; Animals; Dopamine; Humans; In Vitro Techniques; Lentivirus; Mice; Mice, Transgenic; Mutagenesis; Neurotransmitter Agents; Parkinson Disease; Phosphorylation; Protein Phosphatase 2; Serine; Tyrosine; Tyrosine 3-Monooxygenase | 2010 |
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.
Topics: Aged; alpha-Synuclein; Antiparkinson Agents; Autophagy; Female; Gene Frequency; Genotype; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Promoter Regions, Genetic; Reactive Oxygen Species; Sex Distribution; Tyrosine | 2010 |
PAMAM G4 dendrimers affect the aggregation of α-synuclein.
Topics: alpha-Synuclein; Dendrimers; Humans; Protein Binding; Protein Structure, Secondary; Tyrosine | 2011 |
Molecular basis for the glycosphingolipid-binding specificity of α-synuclein: key role of tyrosine 39 in membrane insertion.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid beta-Peptides; Cell Membrane; Gangliosides; Glycosphingolipids; Humans; Membrane Microdomains; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Phosphatidylcholines; Protein Binding; Protein Conformation; Sphingomyelins; Tyrosine | 2011 |
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.
Topics: Allosteric Regulation; alpha-Synuclein; Humans; Hydrodynamics; Lipid Bilayers; Membrane Lipids; Mutation; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Binding; Protein Structure, Secondary; Tyrosine | 2011 |
L-NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation.
Topics: alpha-Synuclein; Animals; Anxiety Disorders; Behavior, Animal; Central Nervous System; Dietary Supplements; Diterpenes; Electron Transport; Glutathione Transferase; Heat-Shock Proteins; Illness Behavior; Locomotion; Male; Manganese; Mitochondria; Monoamine Oxidase; Neurodegenerative Diseases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Dopamine; Receptors, Immunologic; Retinyl Esters; Superoxide Dismutase; Superoxides; Tyrosine; Vitamin A | 2012 |
A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death.
Topics: alpha-Synuclein; Antibodies; Apoptosis; Calcium; Caspase 3; Cell Line, Tumor; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Integrin alpha5beta1; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Polymerization; Recombinant Proteins; Signal Transduction; Tyrosine | 2011 |
Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.
Topics: Aged; alpha-Synuclein; Biomarkers; Colon; Enteric Nervous System; Female; Humans; Male; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Substantia Nigra; Tyrosine | 2012 |
Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.
Topics: Acute-Phase Proteins; Aged; alpha-Synuclein; Biomarkers; Carrier Proteins; Endotoxins; Escherichia coli; Escherichia coli Infections; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Intestines; Male; Membrane Glycoproteins; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Permeability; Sucrose; Tyrosine | 2011 |
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.
Topics: alpha-Synuclein; Amino Acid Sequence; Cells, Cultured; HEK293 Cells; HeLa Cells; Humans; Phosphorylation; Protein Processing, Post-Translational; Sequence Alignment; Tyrosine | 2012 |
Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes.
Topics: alpha-Synuclein; Animals; Cattle; Chickens; Electrochemical Techniques; Electrodes; Fructose-Bisphosphate Aldolase; Graphite; Humans; Protein Denaturation; Proteins; Serum Albumin; Tryptophan; Tyrosine; Urea | 2012 |
Fluorescence lifetime measurements of intrinsically unstructured proteins: application to α-synuclein.
Topics: Algorithms; alpha-Synuclein; Amino Acid Substitution; Anisotropy; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Naphthalenesulfonates; Protein Conformation; Spectrometry, Fluorescence; Staining and Labeling; Tryptophan; Tyrosine | 2012 |
Biophysical properties and cellular toxicity of covalent crosslinked oligomers of α-synuclein formed by photoinduced side-chain tyrosyl radicals.
Topics: alpha-Synuclein; Ammonium Sulfate; Amyloid; Cell Line; Cell Survival; Cross-Linking Reagents; Free Radicals; Humans; Kinetics; Organometallic Compounds; Oxidative Stress; Photochemical Processes; Photosensitizing Agents; Protein Stability; Tyrosine | 2012 |
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
Topics: alpha-Synuclein; Animals; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Focal Adhesion Protein-Tyrosine Kinases; HSC70 Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Tyrosine | 2012 |
Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders.
Topics: alpha-Synuclein; Amino Acid Sequence; Binding Sites; Copper; Cross-Linking Reagents; Fluorescence; Humans; Iron; Lead; Metals; Models, Molecular; Molecular Sequence Data; Neuropeptides; Parkinson Disease; Phosphorylation; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2011 |
May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?
Topics: Albumins; alpha-Synuclein; Biomarkers; Humans; Mass Spectrometry; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Tyrosine | 2013 |
Modulation of human α-synuclein aggregation by a combined effect of calcium and dopamine.
Topics: alpha-Synuclein; Calcium; Calorimetry; Cell Line, Tumor; Circular Dichroism; Dopamine; Humans; Microscopy, Confocal; Microscopy, Electron, Transmission; Mutation; Neuroblastoma; Protein Binding; Protein Transport; Thermodynamics; Transfection; Tyrosine | 2014 |
Electrochemical analysis of the fibrillation of Parkinson's disease α-synuclein.
Topics: alpha-Synuclein; Amyloid; Electrochemical Techniques; Electrodes; Graphite; Humans; Oxidation-Reduction; Parkinson Disease; Protein Folding; Proteostasis Deficiencies; Tyrosine | 2014 |
LC-MS-based urinary metabolite signatures in idiopathic Parkinson's disease.
Topics: alpha-Synuclein; Animals; Biomarkers; Chromatography, Liquid; Drosophila melanogaster; Fatty Acids; Histidine; Humans; Kynurenine; Mass Spectrometry; Metabolomics; Nucleotides; Parkinson Disease; Phenotype; Phenylalanine; Steroids; Tryptophan; Tyrosine | 2015 |
Efficient modification of alpha-synuclein serine 129 by protein kinase CK1 requires phosphorylation of tyrosine 125 as a priming event.
Topics: alpha-Synuclein; Casein Kinase I; Cell Line, Transformed; Green Fluorescent Proteins; Humans; Magnetic Resonance Spectroscopy; Phosphorylation; Serine; Transfection; Tyrosine | 2014 |
The effect of tyrosine residues on α-synuclein fibrillation.
Topics: alpha-Synuclein; Humans; Mutation; Tyrosine | 2015 |
Earliest events in α-synuclein fibrillation probed with the fluorescence of intrinsic tyrosines.
Topics: alpha-Synuclein; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Protein Multimerization; Protons; Recombinant Proteins; Spectrophotometry, Ultraviolet; Tyrosine | 2016 |
Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine.
Topics: alpha-Synuclein; Amino Acid Sequence; Fluorenes; Hydrolysis; Oxidative Stress; Peptides; Prions; Trifluoroacetic Acid; Tyrosine | 2016 |
The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity.
Topics: alpha-Synuclein; Animals; Calmodulin; Cerebral Cortex; Down-Regulation; Humans; Mesencephalon; Neurons; Parkinson Disease; Phosphorylation; Protein Aggregates; Protein Phosphatase 2; Rats; Rotenone; src-Family Kinases; Tyrosine | 2016 |
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Autophagy; Globins; Humans; Lewy Bodies; Nerve Tissue Proteins; Neuroglobin; Oxidation-Reduction; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Serine; Tyrosine | 2016 |
Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.
Topics: alpha-Synuclein; Animals; Brain Infarction; Brain Ischemia; Caspase 3; Death-Associated Protein Kinases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; RNA, Small Interfering; Stroke; Tyrosine | 2016 |
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amino Acid Sequence; Brain; Copper; Dimerization; Electrophoresis, Polyacrylamide Gel; Humans; Lewy Bodies; Male; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Recombinant Proteins; Tandem Mass Spectrometry; Tyrosine | 2016 |
Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.
Topics: alpha-Synuclein; Humans; Oxidative Stress; Protein Aggregation, Pathological; Protein Multimerization; Tyrosine; Ultraviolet Rays | 2017 |
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.
Topics: alpha-Synuclein; Autopsy; Binding Sites; Brain; Humans; Parkinson Disease; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Serine; Single-Domain Antibodies; Tyrosine | 2018 |
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; DNA Damage; Dopamine Plasma Membrane Transport Proteins; Inflammation; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrosative Stress; Oxazoles; Oxidative Stress; Parkinson Disease; Poly Adenosine Diphosphate Ribose; Transcription Factor RelA; Tyrosine; Tyrosine 3-Monooxygenase | 2018 |
Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli.
Topics: alpha-Synuclein; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Protein Engineering; Recombinant Proteins; Tyrosine | 2019 |
α-synuclein interaction with zero-valent iron nanoparticles accelerates structural rearrangement into amyloid-susceptible structure with increased cytotoxic tendency.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Cell Death; Cell Line, Tumor; Congo Red; Humans; Iron; Kinetics; L-Lactate Dehydrogenase; Metal Nanoparticles; Molecular Docking Simulation; Molecular Dynamics Simulation; Oxazines; Protein Aggregates; Protein Structure, Secondary; Spectrometry, Fluorescence; Tyrosine | 2019 |
Biometals as conformational modulators of α-synuclein photochemical crosslinking.
Topics: alpha-Synuclein; Ammonium Sulfate; Coordination Complexes; Copper; Cross-Linking Reagents; Fluorescence; Iron; Light; Organometallic Compounds; Oxidation-Reduction; Photochemical Processes; Photosensitizing Agents; Protein Binding; Protein Conformation; Tyrosine | 2019 |
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Animals; Female; Humans; Lewy Body Disease; Male; Mice; Phosphorylation; Protein Processing, Post-Translational; Serine; Tyrosine | 2020 |
Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly.
Topics: alpha-Synuclein; Amyloid; Humans; Intrinsically Disordered Proteins; Parkinson Disease; Point Mutation; Protein Conformation; Tyrosine | 2020 |
Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.
Topics: alpha-Synuclein; Amyloid; Amyloid beta-Peptides; Cytochromes c; Humans; Magnetic Resonance Spectroscopy; Mitochondria; Neurons; Oxidative Stress; Parkinson Disease; Protein Aggregates; Protein Conformation; Reactive Oxygen Species; Tyrosine | 2020 |
Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled α-Synuclein with Site-Specific Tyrosine Phosphorylation.
Topics: alpha-Synuclein; Molecular Structure; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Tyrosine | 2021 |
Light-Controlled Tyrosine Nitration of Proteins.
Topics: alpha-Synuclein; Animals; Light; Mice; Nitrates; Oxidation-Reduction; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions.
Topics: alpha-Synuclein; Biological Products; Cell Line; Flavonols; Fluorescence; Humans; Hydrophobic and Hydrophilic Interactions; Isoflavones; Kinetics; Metabolome; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Aggregates; Protein Conformation; Scopoletin; Tyrosine | 2021 |
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[
Topics: alpha-Synuclein; Animals; Dependovirus; Disease Models, Animal; Disease Progression; Dopaminergic Neurons; Fluorine Radioisotopes; Male; Motor Activity; Parkinson Disease; Phosphorylation; Positron-Emission Tomography; Protein Aggregates; Rats, Sprague-Dawley; Synucleinopathies; Tyrosine | 2021 |
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amino Acid Substitution; Autopsy; Brain; Casein Kinase II; Cells, Cultured; Female; Humans; Lewy Body Disease; Male; Mutation; Phosphorylation; Serine; Tyrosine | 2021 |
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.
Topics: alpha-Synuclein; Amyloid; Humans; Parkinson Disease; Tyrosine | 2022 |
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro.
Topics: alpha-Synuclein; Alzheimer Disease; Humans; Neurofibrillary Tangles; Protein Conformation, alpha-Helical; tau Proteins; Tyrosine | 2022 |
DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.
Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Humans; Mice; Parkinson Disease; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2022 |
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
Topics: alpha-Synuclein; Animals; Humans; Mice; Mice, Transgenic; Mutation; Neurotoxicity Syndromes; Phenylalanine; Serine; Tyrosine | 2022 |