tyrosine has been researched along with 3-nitrotyrosine in 3420 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (0.41) | 18.7374 |
| 1990's | 274 (8.01) | 18.2507 |
| 2000's | 1819 (53.19) | 29.6817 |
| 2010's | 1240 (36.26) | 24.3611 |
| 2020's | 73 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Bane, S; Banerjee, A; Gal, S; Mukherjee, K; Panosian, TD; Ravindra, R; Sackett, DL | 1 |
| Cheng, CC; Lin, JK | 2 |
| Hincke, MT; Kay, CM; McCubbin, WD | 1 |
| Goodwin, CA; Kakkar, VV; Scully, MF | 1 |
| Beckman, JS; Chen, J; Ischiropoulos, H; Martin, JC; Smith, CD; Tsai, M; Zhu, L | 1 |
| Bagchi, N; Brown, TR; Dhar, A; Sheth, D; Sundick, RS | 1 |
| Curtiss, A; Gross, EL | 1 |
| Bartsch, H; Brouet, I; Friesen, M; Ohshima, H | 2 |
| Breddam, K; Meldal, M | 1 |
| Bartsch, H; Ohshima, H; Shuker, DE | 1 |
| Friederich, U; Fürer, E; Ganss, M; Würgler, FE | 1 |
| Arima, M; Hayashi, A | 1 |
| Chan, SK; Mierzwa, S | 1 |
| Prütz, WA | 1 |
| Carlsson, FH; Louw, AI | 1 |
| Buchholz, R; Meinhold, H | 2 |
| Green, WL | 1 |
| Chang, GG; Chang, TC | 1 |
| Scherrer, P; Stoeckenius, W | 1 |
| Maragos, VA; Riccardi, VM | 1 |
| Holbrook, JJ; Jeckel, D; Parker, DM | 1 |
| Beal, MF; Browne, SE; Matthews, RT; Muqit, MM; Schulz, JB | 1 |
| al-Mehdi, AB; Fisher, AB; Ischiropoulos, H | 1 |
| Poulsen, FM; Rischel, C | 1 |
| Björk, GR; Li, JN | 1 |
| Duran, D; Horwitz, J; Ischiropoulos, H | 1 |
| Beal, MF; Chan, PH; Epstein, CJ; Ferrante, RJ; Henshaw, R; Kowall, NW; Matthews, RT; Schulz, JB | 1 |
| al-Mehdi, AB; Ischiropoulos, H | 1 |
| Coles, B; Heptinstall, J; Richards, PG; Walton, DJ | 1 |
| Beckman, JS; Galliani, C; Haddad, IY; Hu, P; Matalon, S; Pataki, G | 1 |
| Plyte, SE | 2 |
| Halliwell, B; Kaur, H | 1 |
| Accavitti, MA; Anderson, PG; Beckmann, JS; Chen, J; Tarpey, MM; White, CR; Ye, YZ | 1 |
| Glogowski, JA; Leaf, CD; Stillwell, WG; Tannenbaum, SR; Wishnok, JS | 1 |
| Bartsch, H; Friesen, MD; Lin, D; Ohshima, H; Prevost, V; Shuker, DE | 1 |
| Guérin, MC; Salman-Tabcheh, S; Torreilles, J | 1 |
| Ghio, AJ; Oury, TD; Piantadosi, CA; Tatro, L | 1 |
| Abe, K; Itoyama, Y; Kato, T; Pan, LH; Watanabe, M | 1 |
| Bigelow, DJ; Ferrington, DA; Hühmer, AF; Schöneich, C; Viner, RI | 1 |
| Cipolloni, PB; Ferrante, RJ; Henshaw, DR; Jenkins, BG; Kowall, NW; Matthews, RT; Mecocci, P; Rosen, BR; Schulz, JB; Siwek, D | 1 |
| Beers, MF; Fisher, D; Garner, SE; Ischiropoulos, H; Ohnishi, ST; Thom, SR | 1 |
| Beal, MF; Fishman, MC; Huang, PL; Matthews, RT; Passov, D; Schulz, JB | 1 |
| Hurst, JK; Jiang, Q; Lymar, SV | 1 |
| Halliwell, B; Kaur, H; Whiteman, M | 1 |
| Beal, MF; Matthews, RT | 1 |
| Buttery, LD; Carpenter, A; Cohen, J; Evans, TJ; Polak, JM; Springall, DR | 1 |
| Cross, CE; Eiserich, JP; Halliwell, B; Kaur, H; van der Vliet, A | 1 |
| Crow, JP; Ischiropoulos, H | 1 |
| Beckman, JS; Huang, ZQ; Strong, M; Ye, YZ | 1 |
| Brockman, DE; Eis, AL; Greer, I; Lyall, F; Myatt, L; Rosenfield, RB | 1 |
| Evans, P; Halliwell, B; Kaur, H; Mitchinson, MJ | 1 |
| Long, BW; Oberyszyn, TM; Robertson, FM; Ross, MS; Tober, KL | 1 |
| Althaus, JS; Fici, GJ; Hall, ED; Von Voigtlander, PF | 1 |
| Bhattacharya, M; Fiala, ES; Li, H; Sodum, RS | 1 |
| Hashizume, Y; Maruyama, W; Matsubara, K; Naoi, M | 1 |
| Hattori, Y; Hiai, H; Imamura, S; Nikaido, O; Nishigori, C; Osawa, T; Tanaka, T; Toyokuni, S; Uchida, K | 1 |
| Beckman, JS; Crow, JP; Kerby, JD; MacMillan-Crow, LA; Thompson, JA | 1 |
| Kooy, NW; Lewis, SJ | 2 |
| Halliwell, B; Whiteman, M | 3 |
| Anzalone, J; Cohen, AH; Gonick, HC; Khalil-Manesh, F; Ren, Q; Saldanha, LF; Sun, YY | 1 |
| Greis, KD; Matalon, S; Zhu, S | 1 |
| Itoh, T; Kamisaki, Y; Kishimoto, Y; Kitano, M; Nakamoto, K; Wada, K | 1 |
| Beal, MF; Galpern, WR; Isacson, O; Matthews, RT | 1 |
| Augusto, O; Capurro, Mde L; de Bianchi, AG; Giorgio, S; Linares, E | 1 |
| Hardy, MM; Hazen, SL; Heinecke, JW; Leeuwenburgh, C; Oh-ishi, S; Steinbrecher, UP; Wagner, P | 1 |
| Alvarez, RB; Askanas, V; Engel, WK; Yang, CC | 1 |
| Fujimura, H; Okuda, Y; Sakoda, S; Yanagihara, T | 1 |
| Banno, S; Matsumoto, Y; Ohashi, M; Tamada, Y | 1 |
| Beckman, JS; Perry, G; Richey Harris, PL; Sayre, LM; Smith, MA | 1 |
| Ames, BN; Blount, BC; Christen, S; Lee, HH; Shigenaga, MK; Shigeno, ET; Yip, H | 1 |
| Ding, M; Merrill, JE | 1 |
| Bagasra, A; Bagasra, O; Bobroski, L; Pomerantz, RJ; Saikumari, P; Sarker, A | 1 |
| Fukuyama, N; Hida, M; Ichimori, K; Ishida, H; Nakazawa, H; Takebayashi, Y | 1 |
| Hemmens, B; Leopold, E; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Abdalla, DS; Moriel, P | 1 |
| Rabinovitch, A; Suarez-Pinzon, WL; Szabó, C | 1 |
| Brady, T; D'Ambrosio, SM; Oberyszyn, TM; Robertson, FM; Ross, MS | 1 |
| Barnes, PJ; Giaid, A; Saleh, D | 1 |
| Gal, A; Kennedy, LJ; Tamir, S; Tannenbaum, SR; Wogan, GN | 1 |
| Abe, K; Itoyama, Y; Kato, T; Konno, H; Pan, LH; Watanabe, M | 1 |
| Ferro, TJ; Gertzberg, N; Johnson, A; Neumann, P; Selden, L | 1 |
| Chandler, RT; Crow, JP; Parks, DA; Skinner, HB; Skinner, KA; Thompson, JA | 1 |
| Beckman, JS; Kelly, DR; Kooy, NW; Lewis, SJ; Royall, JA; Ye, YZ | 1 |
| Banick, PD; Chen, Q; Thom, SR; Xu, YA | 1 |
| Hinton, DR; Hofman, FM; Incardonna, F; van der Veen, RC | 1 |
| Arends, JW; Buurman, W; Forget, P; ter Steege, J | 1 |
| Blount, BC; Duncan, MW; Smythe, GA; Yi, D | 1 |
| Halliwell, B | 1 |
| Martin, C; Ullrich, V; Zou, M | 1 |
| Ayata, C; Ayata, G; Beal, MF; Christie, RH; Endres, M; Ferrante, RJ; Hara, H; Huang, PL; Hyman, BT; Kim, A; Matthews, RT; Moskowitz, MA; Waeber, C | 1 |
| Hasegawa, Y; Ichiyama, S; Nakashima, I; Nozaki, Y; Shimokata, K | 1 |
| Floyd, RA; Hensley, K; Maidt, ML; Pye, QN; Stewart, CA; Tabatabaie, T; Wack, M | 1 |
| Ischiropoulos, H; Thom, SR; Xu, YA | 1 |
| Beal, MF; Ferrante, RJ; Gurney, ME; Kowall, NW; Matthews, RT; Schulz, JB; Shinobu, LA; Thomas, CE | 1 |
| Bachmann, S; Bosse, HM | 1 |
| Denenberg, A; Menendez, IY; Ryan, M; Wispé, JR; Wong, HR | 1 |
| Beal, MF; Brown, RH; Browne, SE; Ferrante, RJ; Kowall, NW; Matthews, RT | 1 |
| Bruckdorfer, KR; Jacobs, M; Khan, J | 1 |
| Cuzzocrea, S; Gilad, E; Hake, P; Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Beal, MF; Ferrante, RJ; Jenkins, BG; Kaddurah-Daouk, R; Matthews, RT; Rosen, BR; Yang, L | 1 |
| Baliva, F; Fornai, E; Giuntini, C; Mimotti, P; Petruzzelli, S; Pulerà, N; Puntoni, R | 1 |
| Cross, AH; Manning, PT; Misko, TP; Stern, MK | 1 |
| Bätz, M; De Groot, H; Ioannidis, I; Kirsch, M; Korth, HG; Sustmann, R | 1 |
| Ashida, K; Ataka, M; Kamisaki, Y; Kishimoto, Y; Nakamoto, K; Wada, K; Yamada, Y | 1 |
| Barbeito, L; Beckman, JS; Estévez, AG; Henderson, CE; Manuel, SM; Radi, R; Spear, N | 1 |
| Ambs, S; Bennett, WP; Billiar, TR; Felley-Bosco, E; Harris, CC; Klein, S; Merriam, WG; Ogunfusika, MO; Oser, SM; Shields, PG | 1 |
| Cotman, CW; Deng, G; Su, JH | 1 |
| Augusto, O; Giorgio, S; Ischiropoulos, H; Linares, E; Von Zuben, FJ; Yamada, A | 1 |
| Cuzzocrea, S; Salzman, AL; Szabó, C; Zingarelli, B; Zsengellér, Z | 1 |
| Bidmon, HJ; Buchkremer-Ratzmann, I; Mayer, B; Witte, OW; Wu, J; Zilles, K | 1 |
| Fukuyama, N; Hoshiai, K; Ishida, H; Nakazawa, H; Shinohara, Y; Takizawa, S | 1 |
| Bradley, N; Brennan, DM; Brennand, DM; Bruckdorfer, R; Gao, B; Jacobs, M; Khan, J | 1 |
| Hansen, P; Heinecke, JW; Holloszy, JO; Leeuwenburgh, C; Shaish, A | 1 |
| Hiai, H; Kim, BM; Nishimura, Y; Suzuki, S; Tanaka, T; Toyokuni, S; Um, SC | 1 |
| Inoue, S; Kaneko, T; Miyashita, A; Miyazawa, N; Nagashima, Y; Numata, M; Okubo, T; Suzuki, S | 1 |
| Akiba, Y; Fujimori, H; Higuchi, H; Hirokawa, M; Hokari, R; Ishii, H; Kimura, H; Kurose, I; Miura, S; Serizawa, H; Shigematsu, T; Tsuzuki, Y | 1 |
| Halliwell, B; Pannala, AS; Razaq, R; Rice-Evans, CA; Singh, S | 1 |
| Ballard, PL; Ballard, RA; Banks, BA; Ischiropoulos, H; McClelland, M | 1 |
| Halliwell, B; Jenner, P; Kaur, H; Lyras, L | 1 |
| Bigelow, DJ; Krainev, AG; Williams, TD | 1 |
| Good, PF; Hsu, A; Olanow, CW; Perl, DP; Werner, P | 1 |
| Bry, K; Hallman, M; Lappalainen, U; Turbow, R; Waffarn, F | 1 |
| Arnaud, S; Ben-Ari, Y; Cachin, N; Charriaut-Marlangue, C; Coeroli, L; Plotkine, D; Plotkine, M; Renolleau, S | 1 |
| Fujimura, T; Murayama, K; Taka, H; Yamakura, F | 1 |
| Crowley, JR; Heinecke, JW; Leeuwenburgh, C; Turk, J; Yarasheski, K | 1 |
| Hinson, JA; Mayeux, PR; Pike, SL; Pumford, NR | 1 |
| Albala, A; Barbone, A; Cannon, PJ; Michler, RE; Ming, M; Ravalli, S; Szabolcs, M | 1 |
| Fukuyama, N; Nakazawa, H; Sakai, M; Sato, M | 1 |
| Bhattacharjee, M; Butunoi, C; Katsetos, CD; Legido, A; Oleszak, EL; Zaczynska, E | 1 |
| Caputi, AP; Cuzzocrea, S; Longo, G; Villari, D; Zingarelli, B | 1 |
| Beckman, JS; Crow, JP; Sopper, MM; Strong, MJ; Strong, WL | 1 |
| Baier-Bitterlich, G; Fuchs, D; Wede, I; Widner, B; Wirleitner, B | 1 |
| Cross, AH; Keeling, RM; Manning, PT; Misko, TP; Schmidt, RE | 1 |
| Fakhrzadeh, L; Gardner, CR; Heck, DE; Laskin, DL; Laskin, JD; Weinberger, B | 1 |
| Huang, T; Kissinger, CB; Kissinger, PT; Liu, H | 1 |
| Caputi, AP; Cuzzocrea, S; Zingarelli, B | 1 |
| Balabanli, B; Behbod, F; Bian, K; Davis, K; Kamisaki, Y; Lee, YC; Martin, E; Murad, F; Wada, K | 1 |
| Crowley, JR; Hollenberg, PF; Lin, Hl; Osawa, Y; Roberts, ES; Vuletich, JL | 1 |
| Floyd, RA; Hensley, K; Maidt, ML; Markesbery, WR; Sang, H; Yu, Z | 1 |
| Beal, MF; Hyman, BT; Klockgether, T; Liao, AW; Martinou, JC; Matthews, RT; Penney, JB; Schulz, JB; Yang, L | 1 |
| Cuzzocrea, S; Marmer, D; Salzman, AL; Scott, GS; Szabó, C; Virág, L | 1 |
| Aruda, WO; Duda, CT; Huang, T; Kissinger, PT; Liu, H | 1 |
| Brockman, DE; Eis, AL; Gibson, JL; Greer, IA; Lyall, F; Myatt, L | 1 |
| Leong, SK; Ng, YK; Xu, M | 1 |
| Fukuyama, N; Genka, C; Ishida, H; Nakazawa, H; Su, Z; Todorov, R | 1 |
| Hori, Y; Horie, K; Hoshino, J; Miyauchi, S; Mizuno, S; Sekiguchi, T; Yamazaki, C | 1 |
| Abe, K; Fukuyama, N; Hayashi, T; Nakazawa, H; Sakurai, M; Shinohara, Y; Tabayashi, K; Takizawa, S | 1 |
| Halliwell, B; Jenner, P; Marshall, KA; Reist, M | 1 |
| Buurman, WA; Forget, PP; Koster-Kamphuis, L; ter Steege, JC; van Straaten, EA | 1 |
| Bryan, TW; Grisham, MB; Jinkins, PA; Jones, KL; Markewitz, BA; Milligan, SA; Owens, MW; Robbins, RA; Simpson, KL | 1 |
| Ahmed, F; Anthony, GM; Bank, N; Fabry, ME; Kiroycheva, M; Nagel, RL; Singhal, PC | 1 |
| Goldberg, P; Hussain, SN; Kristof, AS; Laubach, V | 1 |
| Cuzzocrea, S; Salzman, AL; Szabó, A; Szabó, C; Virág, L; Zingarelli, B | 1 |
| Henkart, PA; Noguchi, S; Osawa, Y; Williams, MS | 1 |
| Cuzzocrea, S; Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Haramaki, N; Ikeda, H; Imaizumi, T; Mori, E | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E | 2 |
| Beal, MF; Dhawan, J; Disatnik, MH; Franco, AA; Rando, TA; Whirl, MM; Yu, Y | 1 |
| Chen, JS; Chen, LW; Chen, SC; Hsu, CM; Wang, JS | 1 |
| Hyun, B; Jin, J; Kim, K; Kim, S; Kohyama, K; Matsumoto, Y; Moon, C; Shin, T; Tanuma, N | 1 |
| Badolato, R; Caruso, A; Chilosi, M; Duse, M; Facchetti, F; Fiorentini, S; Notarangelo, LD; Vermi, W | 1 |
| Bible, KC; Boerner, SA; Kaufmann, SH | 1 |
| Shigenaga, MK | 1 |
| Crow, JP | 1 |
| Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Barbeito, L; Beckman, JS; Estévez, AG; Manuel, SM; Radi, R; Spear, N | 1 |
| Cannon, C; Gilkeson, G; Goldman, D; Oates, J; Petri, M; Reilly, C | 1 |
| Chakravortty, D; Kato, Y; Koide, N; Morikawa, A; Sugiyama, T; Yokochi, T; Yoshida, T | 1 |
| Buurman, WA; Forget, PP; ter Steege, JC | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S | 1 |
| Akizuki, E; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Yamada, S; Yamaguchi, Y | 1 |
| Fisher, D; Garner, S; Ischiropoulos, H; Thom, SR; Xu, YA | 1 |
| Andreassen, OA; Beal, MF; Bogdanov, MB; Ferrante, RJ; Kaddurah-Daouk, R; Klein, AM; Klivenyi, P; Matthews, RT; Mueller, G; Wermer, M | 1 |
| Ellis, C; Green, M; MacMillan-Crow, LA; Thompson, JA; Vickers, SM | 1 |
| Brito, C; Cayota, AM; Dighiero, G; Gualco, G; Naviliat, M; Radi, R; Tiscornia, AC; Vuillier, F | 1 |
| Beal, MF; Brouillet, E; Ferrante, RJ; Hantraye, P | 1 |
| Hiai, H; Nishimura, Y; Suzuki, S; Toyokuni, S; Uchida, K; Um, SC | 1 |
| Herce-Pagliai, C; Kotecha, S; Shuker, DE | 1 |
| Balazy, M; Jiang, H | 1 |
| Bruno, J; Holwitt, E; Kalns, J; Kiel, J; Parker, J; Piepmeier, E | 1 |
| Arteel, GE; Bradford, BU; Kadiiska, MB; Mason, RP; Raleigh, JA; Rusyn, I; Thurman, RG | 1 |
| Hiramoto, K; Kikugawa, K; Nakauchi, K; Tomiyama, S | 1 |
| Bachmaier, K; Liu, P; Mak, TW; Neu, N; Penninger, JM; Yeung, RS | 1 |
| Boven, LA; Gomes, L; Gray, F; Hery, C; Nottet, HS; Portegies, P; Tardieu, M; Verhoef, J | 1 |
| de Jager-Krikken, A; Dijkstra, G; Jansen, PL; Kleibeuker, JH; Moshage, H; Tiebosch, AT; van Dullemen, HM; van Goor, H | 1 |
| Calingasan, NY; Gibson, GE; Kristal, BS; Lindsay, JG; Park, LC; Sheu, KF; Zhang, H | 1 |
| Jendral, M; Ullrich, V; Zou, M | 1 |
| Briviba, K; Klotz, LO; Schieke, SM; Sies, H | 1 |
| Kojima, M; Matsunari, Y; Mibu, R; Morisaki, T; Tanaka, M; Tsukahara, Y; Uchiyama, A | 1 |
| Beal, MF; Klivenyi, P; Matthews, RT; Mueller, G; Thomas, CE; Wermer, M; Yang, L | 1 |
| Fung, HL; Maurer, TS; Tabrizi-Fard, MA | 1 |
| Fukui, M; Sayama, T; Suzuki, S | 1 |
| Darley-Usmar, VM; Freeman, BA; Jo, H; McAndrew, J; Patel, RP; Sellak, H; White, CR | 1 |
| Leist, M; Ullrich, V; Zou, MH | 1 |
| Moreno, C; Riveros-Moreno, V; Sosnowska, D; Venkataprasad, N | 1 |
| Bamberg, TV; Beckman, JS; Chumley, PH; Eiserich, JP; Estévez, AG; Freeman, BA; Ye, YZ | 1 |
| Blazar, BR; Haddad, IY; Ingbar, DH; Milla, CE; Panoskaltsis-Mortari, A; Yang, S | 1 |
| Depre, C; Havaux, X; Renkin, J; Vanoverschelde, JL; Wijns, W | 1 |
| Miampamba, M; Sharkey, KA | 1 |
| Bigelow, DJ; Ferrington, DA; Schöneich, C; Viner, RI; Williams, TD | 1 |
| Fukuyama, N; Hirabayashi, H; Nakazawa, H; Shinohara, Y; Takizawa, S | 4 |
| Celan, I; Chazotte, L; Mower, HF; Ohshima, H; Pignatelli, B | 1 |
| Fu, W; Guo, Q; Holtsberg, FW; Mattson, MP; Steiner, SM | 1 |
| Fedan, JS; Jones, JA; Kommineni, C; Rengasamy, A | 1 |
| Ahn, B; Han, BS; Kim, DJ; Ohshima, H | 1 |
| Ptitsyn, OB; Tcherkasskaya, O | 1 |
| Goto, T; Haruma, K; Hayakawa, N; Ito, M; Kajiyama, G; Kitadai, Y; Sumii, K; Yoshihara, M | 1 |
| Cross, CE; Eiserich, JP; Shigenaga, MK; van der Vliet, A | 1 |
| Berlett, BS; Chock, PB; Levine, RL; Stadtman, ER; Tien, M | 1 |
| Hansson, GK; Henderson, AM; Hunter, GC; Kobayashi, H; Putnam, CW; Sirsjo, A; Suzuki, F; Westerband, A; Yan, ZQ | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E; Micali, A; Zingarelli, B | 1 |
| Caputi, AP; Ciriaco, E; Costantino, G; Cuzzocrea, S; de Sarro, A; de Sarro, G; Laurà, R; Mazzon, E | 1 |
| Amirmansour, C; Bogle, RG; Vallance, P | 1 |
| Abe, T; Ishizaki, E; Isobe, C; Murata, T; Tohgi, H; Yamazaki, K | 2 |
| Maeda, S; Saeki, M | 1 |
| Eliasson, MJ; Ferrante, RJ; Huang, Z; Molliver, ME; Moskowitz, MA; Sasamata, M; Snyder, SH | 1 |
| Bian, K; Binder, L; Davis, K; Kuret, J; Murad, F | 1 |
| Kanadia, RN; Kuo, WN; Shanbhag, VP | 1 |
| Bair, R; Haddad, IY; Heinecke, J; Ingbar, DH; Jung, P | 1 |
| Di Stasi, AM; Macchia, G; Mallozzi, C; Minetti, M; Petrucci, TC | 1 |
| Fukuyama, N; Hataishi, R; Hirano, S; Honda, K; Kobayashi, H; Nakazawa, H; Tomita, T | 1 |
| Grisham, MB; Koyama, S; Robbins, RA; Sato, E; Simpson, KL | 3 |
| Ali, SF; Crow, JP; Imam, SZ; Islam, F; Newport, GD; Slikker, W | 1 |
| DiMarco, A; Nethery, D; Stofan, D; Supinski, G; Szweda, L | 1 |
| Baudry, M; Doctrow, SR; Rong, Y; Tocco, G | 1 |
| Chen, Y; Hazen, SL; Wu, W | 1 |
| Caputi, AP; Costantino, G; Cuzzocrea, S; Zingarelli, B | 1 |
| Brown, LA; Fortenberry, JD; Owens, ML; Raghuram, N | 1 |
| Brain, SD; Evans, P; Greenacre, SA; Halliwell, B | 1 |
| Evans, TW; Gutteridge, JM; Lamb, NJ; Quinlan, GJ; Westerman, ST | 1 |
| Harrisson, F; Tao, L; van Nassauw, L | 1 |
| Kastenbauer, S; Koedel, U; Pfister, HW | 1 |
| Brown, MC; Camporesi, EM; Cucchiaro, G; Daucher, JW; Hakim, TS; Tatum, AH | 1 |
| Bauer, JA; Coyle, CM; Jing, L; Mihm, MJ | 1 |
| Connor, JR; Currie, MG; Fernandes, JC; Jovanovic, D; Lascau-Coman, V; Manning, P; Martel-Pelletier, J; Pelletier, JP | 1 |
| Caputi, AP; Ciliberto, G; Costantino, G; Cuzzocrea, S; De Sarro, A; De Sarro, G; Mazzon, E | 1 |
| Bakhøj, A; Heegaard, NH | 1 |
| Ding, Y; Liang, K; Vaziri, ND | 1 |
| Balligand, JL; Combet, S; Devuyst, O; Goffin, E; Lameire, N; Moulin, P; Piech, A; Van Landschoot, M; Verbavatz, JM | 1 |
| Baker, C; Evans, TW; Gutteridge, JM; Lamb, NJ; Quinlan, GJ | 1 |
| Bidmon, HJ; Dringen, R; Hilbig, H; Mehl, M; Ullrich, V; Zilles, K | 1 |
| Doi, U; Kato, Y; Niwa, T; Osawa, T | 2 |
| Cuzzocrea, S; McDonald, MC; Mota-Filipe, H; Thiemermann, C | 1 |
| Quaroni, L; Smith, WE | 1 |
| Hirata, K; Isobe, M; Katsuramaki, T; Kimura, H; Matsuno, T; Nagayama, M | 1 |
| Higuchi, H; Hokari, R; Ishii, H; Kimura, H; Miura, S; Mizumori, M; Mori, M; Sakaguchi, AA; Suzuki, H; Takeuchi, T; Yoshida, H | 1 |
| Michaelis, ML; Zaidi, A | 1 |
| Farber, HW; Hammerman, SI; Hendra, KP; Klings, ES; Loscalzo, J; Rishikof, DC; Upchurch, GR | 1 |
| Carroll, N; James, A; Janssen, Y; Kaminsky, DA; Mitchell, J; Soultanakis, R | 1 |
| Amiel, D; Coutts, RD; Hashimoto, S; Lotz, M; Ochs, RL; Takahashi, K | 1 |
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| Delatour, T; Guy, PA; Stadler, RH; Turesky, RJ | 1 |
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| Bednar, RM; Beyer, JN; Cooley, RB; Gottfried-Lee, I; Hosseinzadeh, P; Karplus, PA; Mehl, RA; Van Fossen, EM; Zhu, P | 1 |
| Aljasir, MA; Almatroodi, SA; Almatroudi, A; Alsahli, MA; Rahmani, AH; Syed, MA | 1 |
| Baumgart-Vogt, E; Bednorz, M; Brandes, RP; Buchmann, G; Dorfmüller, P; Eichstaedt, C; Fysikopoulos, A; Gattenlöhner, S; Geiszt, M; Ghofrani, HA; Gredic, M; Grimminger, F; Grünig, E; Günther, A; Hadzic, S; Hecker, A; Hecker, M; Henneke, I; Hinderhofer, K; Jaksch, P; Kanbagli, ZI; Karnati, S; Klepetko, W; Knoepp, F; Kojonazarov, B; Kraut, S; Müller, N; Padberg, W; Pak, O; Parajuli, N; Pichl, A; Rezende, F; Scheibe, S; Schermuly, RT; Schröder, K; Seeger, W; Seimetz, M; Sommer, N; Veith, C; Vogelmeier, CF; Weissmann, N; Wilhelm, J; Wittig, I; Wu, CY | 1 |
| Choromańska, B; Choromańska, K; Dadan, J; Maciejczyk, M; Myśliwiec, H; Myśliwiec, P; Wojskowicz, P; Zalewska, A; Łuba, M | 1 |
| Fu, J; Wang, K; Wang, Y | 1 |
| Burnett, AL; Chen, H; Karakus, S; La Favor, JD; Musicki, B; Silva, FH; Sturny, M; Zirkin, BR | 1 |
| Aktekin, CN; Bek, ZA; Bitik, B; Elmazoglu, Z; Goker, B; Karasu, Ç; Özoğul, C; Sarıbaş, GS | 1 |
| Dong, Z; Han, J; Wei, Z; Zhang, Y | 1 |
| Campo, VE; Cecchini, AL; Cecchini, R; Cela, EM; González-Maglio, DH; Marinello, PC; Melo, GP; Ramalho, LZN; Souza-Neto, FP | 1 |
| Chen, CY; Chen, KY; Chen, LY; Huang, HH; Lee, YC; Tsai, CY | 1 |
| Fleszar, MG; Fortuna, P; Kosyk, B; Krzystek-Korpacka, M; Zawadzki, M | 1 |
| Ahmad, S; Bhatia, K; Ducruet, AF; Hoda, MN; Kindelin, A; Mahady, L; Nadeem, M | 1 |
| Bouř, P; Keiderling, TA; Neburková, J; Niederhafner, P; Šafařík, M; Šebestík, J | 1 |
| Afzal, O; Al-Abbasi, FA; Altamimi, ASA; Gubbiyappa, KS; Kazmi, I; Shiroorkar, PN; Sreeharsha, N | 1 |
| Arzhanova, O; Chepanov, S; Kapustin, R; Kopteeva, E | 1 |
| Bruno, G; Lackmann, JW; Lalk, M; von Woedtke, T; Wende, K; Wenske, S | 1 |
| Bailey, WM; Gensel, JC; McFarlane, KE; Patel, SP; Slone, SA; Stewart, AN; Sullivan, PG; Tranthem, LA; Vekaria, HJ; Zhang, B | 1 |
| Alharbi, S; Andersen, CR; Baljinnyam, T; Enkhbaatar, P; Fukuda, S; Ihara, K; Jacob, S; Kim, J; Niimi, Y; Pérez-Bello, D; Prough, DS | 1 |
| Cheng, A; Fukunaga, K; Izumi, H; Kawahata, I; Xu, J; Yuan, D | 1 |
| Kai, Y; Kakinuma, Y; Kurabayashi, A; Mano, A; Ohata, H; Oikawa, S; Tsuda, M | 1 |
| Ahmad, K; Ahmad, SS; Cho, WK; Choi, I; Lee, EJ; Lee, YH; Lim, JH; Ma, JY; Park, S; Park, SJ; Park, SY; Shaikh, S; Yang, HJ | 1 |
| Autore, G; Dal Piaz, F; Di Iorio, BR; Iovane, V; Marzocco, S; Nishijima, F; Paciello, O; Popolo, A; Prisco, F; Rapa, SF | 1 |
| Afonso, C; Bonino, L; Borthagaray, G; López, E; Medeiros, R; Pitt, A; Rossi, S; Sousa, B; Spickett, C | 1 |
| Dhangar, S; George, M; Mohan, S; Mohanty, P; Rajendran, A; Solanki, A; Vundinti, BR | 1 |
| Auliah, FN; Hasan, MM; Kurata, H; Moni, MA; Nilamyani, AN; Shoombuatong, W | 1 |
| Chong, SJF; Goh, BC; Kong, LR; Pervaiz, S; Yee, YH | 1 |
| Hegemann, JD; Liu, L; Long, T; Quan, J; Tao, Y; Tian, H; Uesugi, M; Wang, H; Yao, W; Zhang, W; Zheng, J | 1 |
| Baer, LA; Davis, IC; Doolittle, LM; Hickman-Davis, JM; Karekar, P; Nelson, AM; Nolan, KE; Rosas, LE; Singh, H; Stanford, KI | 1 |
| Chaput, D; Chavez-Chiang, O; Culver-Cochran, AE; Duro, N; Guergues, J; Kriss, CL; Nadeau, OW; Stevens, SM; Varma, S | 1 |
| Eckhardt, A; Kohutiar, M | 1 |
| Harris, MB; Hoffman, RM; Olesiak, M | 1 |
| Alfano, R; Balta, C; Cotoraci, C; D'Amico, M; Galdiero, M; Gesualdo, C; Gharbia, S; Gherghiceanu, M; Herman, H; Hermenean, A; Mladin, B; Peteu, VE; Petrillo, F; Rossi, S; Trotta, MC | 1 |
| Chen, M; Li, Q; Li, S; Lu, T; Min, S; Zhang, C | 1 |
| Bijak, M; Kowal, P; Marchewka, Z; Saluk-Bijak, J; Sawicka, E; Szymańska, B; Wigner, P | 1 |
| Babu, GN; Gupta, M; Paliwal, VK | 1 |
| Gradek, J; Kusmierczyk, J; Szygula, Z; Szymura, J; Wiecek, M | 1 |
| Bartesaghi, S; Batthyány, C; Campolo, N; Grune, T; Leyva, A; Mastrogiovanni, M; Meinl, W; Ott, C; Radi, R; Tomasina, F | 1 |
| Jiang, C; Jiang, Q; Li, S; Ran, J; Wu, Y; Xue, L; Yang, C; Yang, J; Zhou, S | 1 |
| Azul, L; Figueirinha, A; Leandro, A; Queiroz, M; Seiça, R; Sena, CM | 1 |
| Chen, K; Gao, X; Hu, C; Jiang, Z; Liu, K | 1 |
| Bulić-Jakuš, F; Himelreich-Perić, M; Ježek, D; Jurić-Lekić, G; Katušić-Bojanac, A; Krasić, J; Majić, Ž; Marić, A; Šerman, L; Sinčić, N; Sobočan, N | 1 |
| Calderón-Torres, CM; Murguía-Romero, M; Ortiz-Reyes, AE | 1 |
| Carrillo, R; García-Rodríguez, R; Lahoz, F; Pérez-Márquez, LA; Perretti, MD | 1 |
| Camilus, N; Gao, S; Macairan, JR; Martic, S; Mitti, M; Naccache, R | 1 |
| Geng, J; Li, Y; Lin, H; Liu, Q; Lu, J; Wang, X | 1 |
| Biswas, S; Mukherjee, S; Sarkar, K | 1 |
| Berkemeier, T; Lelieveld, S; Mishra, A; Pöschl, U | 1 |
93 review(s) available for tyrosine and 3-nitrotyrosine
| Article | Year |
|---|---|
Human nitrosamine exposure: recent dosimetry methods and applications.
Topics: Adenine; Biomarkers; Carcinogens; DNA Damage; Humans; Nitrosamines; Nitroso Compounds; Tyrosine | 1991 |
Urinary markers for exposures to alkylating or nitrosating agents.
Topics: Adenine; Alkylating Agents; Animals; Biomarkers; Dimethylnitrosamine; DNA Damage; Humans; Nitric Oxide; Nitrosamines; Nitroso Compounds; Risk Factors; Stomach Neoplasms; Tyrosine | 1993 |
Urinary markers for measuring exposure to endogenous and exogenous alkylating agents and precursors.
Topics: Acetylcysteine; Adenine; Alkylating Agents; Animals; Biomarkers; DNA Damage; Environmental Monitoring; Humans; Tyrosine | 1993 |
Nitrotyrosine as biomarker for reactive nitrogen species.
Topics: Air Pollution; Animals; Biomarkers; Humans; Methods; Nitric Oxide; Nitrogen Dioxide; Poisons; Tyrosine | 1996 |
Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitrite.
Topics: Chromatography, High Pressure Liquid; Proteins; Spectrum Analysis; Tyrosine | 1996 |
Antibodies that recognize nitrotyrosine.
Topics: Animals; Antibodies; Cattle; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Sensitivity and Specificity; Tyrosine | 1996 |
Quantitation of protein-bound 3-nitrotyrosine by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Protein Binding; Tyrosine | 1999 |
Measurement and significance of free and protein-bound 3-nitrotyrosine, 3-chlorotyrosine, and free 3-nitro-4-hydroxyphenylacetic acid in biologic samples: a high-performance liquid chromatography method using electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Nitrophenols; Phenylacetates; Protein Binding; Proteins; Tyrosine | 1999 |
Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Humans; Motor Neurons; Nitrates; Nitric Oxide; Superoxide Dismutase; Tyrosine | 1998 |
Analytical methods for 3-nitrotyrosine as a marker of exposure to reactive nitrogen species: a review.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Environmental Exposure; Free Radicals; Humans; Mass Spectrometry; Molecular Structure; Nitric Oxide; Tyrosine | 1998 |
Biological aspects of reactive nitrogen species.
Topics: Animals; Apoptosis; Inflammation; Lipoproteins; Membranes; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Oxidation-Reduction; Signal Transduction; Tyrosine; Vasodilation | 1999 |
Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?
Topics: Animals; Free Radicals; Humans; Inflammation; Lung; Lung Diseases; Nitric Oxide; Tyrosine | 1999 |
Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies.
Topics: Animals; Biomarkers; Disease; Humans; Nitrates; Nitric Oxide; Superoxides; Tyrosine | 1999 |
Endotoxin-endothelium interactions in "low-perfusion state" research.
Topics: Anesthesia; Animals; Dexamethasone; Endothelium, Vascular; Endotoxins; In Vitro Techniques; Liver; Mice; Nitric Oxide; Spleen; Tyrosine | 1999 |
Measurement of 3-nitrotyrosine and 5-nitro-gamma-tocopherol by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Electrochemistry; gamma-Tocopherol; Humans; Oxidative Stress; Reactive Oxygen Species; Tyrosine; Vitamin E | 2000 |
How important is oxidative damage? Lessons from Alzheimer's disease.
Topics: Alzheimer Disease; DNA Damage; Free Radicals; Glycation End Products, Advanced; Humans; Lipid Peroxidation; Models, Neurological; Neurofilament Proteins; Oxidative Stress; RNA; Tyrosine | 2000 |
Histochemical and immunocytochemical approaches to the study of oxidative stress.
Topics: Alzheimer Disease; Biomarkers; DNA Damage; Glycation End Products, Advanced; Histocytochemistry; Humans; Immunohistochemistry; Metals; Oxidation-Reduction; Oxidative Stress; Phenylhydrazines; Tyrosine | 2000 |
Nitric oxide, peroxynitrite, and lower respiratory tract inflammation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cystic Fibrosis; Eosinophils; Humans; Nitrates; Nitric Oxide; Pneumonia; Tyrosine | 2000 |
Unraveling peroxynitrite formation in biological systems.
Topics: Animals; Carbon Dioxide; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Humans; Hydroxylation; Immunohistochemistry; Indicators and Reagents; Luminescent Measurements; Nitrates; Oxidants; Oxidative Stress; Phenols; Tyrosine | 2001 |
Nitrotyrosine formation and its role in various pathological conditions.
Topics: Animals; Brain Ischemia; Cell Survival; Cells, Cultured; Coculture Techniques; Disease; Dogs; Endothelium, Vascular; Lung Diseases; Male; Myocardium; Neutrophils; Radiation Injuries; Rats; Reperfusion Injury; Tyrosine | 2000 |
Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts.
Topics: Animals; Antioxidants; Biomarkers; Dopamine; Dopamine Agents; Enzyme Inhibitors; Humans; Indazoles; Methamphetamine; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; PC12 Cells; Rats; Tyrosine | 2001 |
Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction.
Topics: Animals; Disease; Humans; Nitrates; Proteins; Signal Transduction; Tyrosine | 2001 |
The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: impact of diet.
Topics: Animals; Diet; Humans; Nitrates; Nitric Oxide; Nitrites; Reactive Nitrogen Species; Tyrosine | 2001 |
Protein oxidation in aging and age-related diseases.
Topics: Aging; Amino Acids; Animals; Antioxidants; Apoptosis; Cross-Linking Reagents; Cysteine; Disease; Humans; Longevity; Methionine; Models, Biological; Nitric Oxide; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptides; Peroxynitrous Acid; Protein Denaturation; Proteins; Rats; Reactive Oxygen Species; Tyrosine | 2001 |
[Infections and NO].
Topics: Animals; Biomarkers; Humans; Infections; Inflammation Mediators; Interferon-gamma; Nitric Oxide; Nitric Oxide Synthase; Superoxides; Tyrosine | 2001 |
Aging and the role of reactive nitrogen species.
Topics: Aging; Animals; Diet; Humans; Molecular Structure; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteins; Reactive Nitrogen Species; Tyrosine | 2002 |
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Topics: Carbonates; Free Radicals; Nitrogen Dioxide; Oxidation-Reduction; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2002 |
Nitric oxide trapping of the tyrosyl radical-chemistry and biochemistry.
Topics: Electron Spin Resonance Spectroscopy; Free Radicals; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Tyrosine | 2002 |
Nitrotyrosine: new findings as a marker of postprandial oxidative stress.
Topics: Animals; Biomarkers; Diabetic Angiopathies; Endothelium, Vascular; Humans; Hyperglycemia; Hypertriglyceridemia; Hypolipidemic Agents; Oxidative Stress; Postprandial Period; Rats; Simvastatin; Tyrosine | 2002 |
Peroxynitrite reactions and formation in mitochondria.
Topics: Animals; Cell Death; Cell Line; Diffusion; Electron Transport; Free Radicals; Humans; Mice; Mitochondria; Models, Biological; Models, Chemical; Nitric Oxide; Nitrogen Dioxide; Peroxynitrous Acid; Rats; Tumor Cells, Cultured; Tyrosine | 2002 |
Nitric oxide, nitrotyrosine, and nitric oxide modulators in asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Breath Tests; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Proteomics; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Tyrosine | 2003 |
[3-nitrotyrosine--an indicator of changes in the formation of reactive oxygen and nitrogen species].
Topics: Animals; Biomarkers; Humans; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2002 |
Biological selectivity and functional aspects of protein tyrosine nitration.
Topics: Amino Acid Sequence; Disease Susceptibility; Humans; Nitric Oxide; Protein Processing, Post-Translational; Proteins; Tyrosine | 2003 |
Roles of nitric oxide and superoxide in inflammation.
Topics: 2-Naphthylamine; Animals; Arginine; Blotting, Western; Capillary Permeability; Chemotaxis, Leukocyte; Citrulline; Fluorescent Dyes; Fluorometry; Inflammation; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rats; Superoxides; Tyrosine | 2003 |
Acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cytokines; Humans; Kupffer Cells; Liver Diseases; Mitochondria, Liver; Oxidative Stress; Tyrosine | 2003 |
Peroxynitrite-dependent modifications of tyrosine residues in hemoglobin. Formation of tyrosyl radical(s) and 3-nitrotyrosine.
Topics: Animals; Carbon Dioxide; Catalysis; Ferric Compounds; Free Radicals; Hemoglobins; Humans; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2003 |
A review of approaches to the analysis of 3-nitrotyrosine.
Topics: Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Liquid; Electrochemistry; Humans; Mass Spectrometry; Molecular Structure; Tyrosine | 2003 |
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
Topics: Algorithms; Animals; Humans; Hydrogen Peroxide; Nitric Oxide; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; S-Nitrosothiols; Superoxides; Tyrosine | 2004 |
Role for oxidative stress in the regeneration of islet beta cells?
Topics: Animals; Cell Division; Diabetes Mellitus, Type 1; Humans; Islets of Langerhans; Mice; Mice, Congenic; Mice, Inbred NOD; Oxidative Stress; Regeneration; Tyrosine | 2004 |
Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?
Topics: Animals; Apoptosis; Humans; Neurons; Oxidative Stress; Peroxynitrous Acid; Potassium Channels, Voltage-Gated; Tyrosine; Zinc | 2004 |
Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?
Topics: Animals; Biomarkers; Biopterins; Dopamine; Humans; Neurons; Peroxynitrous Acid; Quinones; Tyrosine | 2004 |
Biological significance of nitric oxide-mediated protein modifications.
Topics: Humans; Nitric Oxide; Protein Processing, Post-Translational; Proteins; S-Nitrosothiols; Tyrosine | 2004 |
Recent methodological advances in the mass spectrometric analysis of free and protein-associated 3-nitrotyrosine in human plasma.
Topics: Humans; Mass Spectrometry; Oxidative Stress; Reference Standards; Sensitivity and Specificity; Tyrosine | 2005 |
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
Topics: Animals; Cardiomyopathies; Diabetes Complications; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Endothelium, Vascular; Humans; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Superoxides; Tyrosine | 2005 |
Immunogenicity of an inflammation-associated product, tyrosine nitrated self-proteins.
Topics: Animals; Autoantibodies; Autoantigens; Epitopes; Inflammation; Protein Processing, Post-Translational; Proteins; Tyrosine | 2005 |
[Nitric oxide and its related compounds].
Topics: Asthma; Biomarkers; Carbon Monoxide; Chromatography, Gas; Chromatography, High Pressure Liquid; Clinical Enzyme Tests; Enzyme-Linked Immunosorbent Assay; Guanine; Infections; Neoplasms; Nitric Oxide; Pulmonary Disease, Chronic Obstructive; Reference Values; Sepsis; Tyrosine | 2005 |
Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis.
Topics: Animals; Bacterial Infections; DNA Damage; DNA Repair; Guanosine; Humans; Inflammation; Mice; Models, Biological; Mutagenesis; Nitric Oxide; Nitro Compounds; Oxidation-Reduction; RNA; Tyrosine; Virus Diseases; Virus Replication | 2006 |
Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system.
Topics: Animals; Atherosclerosis; Endothelium, Vascular; Humans; Oxidative Stress; Tyrosine; Vasculitis | 2006 |
Reactive nitrogen species in the respiratory tract.
Topics: Animals; Asthma; Cystic Fibrosis; Humans; Nitric Oxide; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Nitrogen Species; Reactive Oxygen Species; Respiratory System; Tyrosine | 2006 |
The biological chemistry of nitric oxide as it pertains to the extrapulmonary effects of inhaled nitric oxide.
Topics: Administration, Inhalation; Animals; Humans; Nitric Oxide; Oxidation-Reduction; S-Nitrosothiols; Tyrosine | 2006 |
Lipid nitration and formation of lipid-protein adducts: biological insights.
Topics: alpha-Synuclein; Humans; Lipid Metabolism; Lipids; Lipoproteins, LDL; Nitrates; Oxidative Stress; Proteins; Reactive Nitrogen Species; Tyrosine | 2007 |
Protein tyrosine nitration in hydrophilic and hydrophobic environments.
Topics: Cell Membrane; Dimerization; Free Radicals; Hydrophobic and Hydrophilic Interactions; Peptides; Proteins; Tyrosine | 2007 |
Chromatographic and mass spectrometric methods for quantitative determination of 3-nitrotyrosine in biological samples and their application to human samples.
Topics: Body Fluids; Chromatography, Liquid; Humans; Mass Spectrometry; Tyrosine | 2007 |
Biochemistry of protein tyrosine nitration in cardiovascular pathology.
Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Fibrinogen; Humans; Nitric Oxide; Nitrosation; Signal Transduction; Superoxide Dismutase; Tyrosine | 2007 |
Sulfation of nitrotyrosine: biochemistry and functional implications.
Topics: Animals; Arylsulfotransferase; Humans; Sulfates; Sulfotransferases; Tyrosine | 2007 |
New insights into nitric oxide signaling in plants.
Topics: Nitrates; Nitric Oxide; Plant Physiological Phenomena; Plant Proteins; Protein Kinases; Signal Transduction; Tyrosine | 2008 |
Nitrotyrosine-modified SERCA2: a cellular sensor of reactive nitrogen species.
Topics: Aging; Animals; Biosensing Techniques; Energy Metabolism; Humans; Models, Molecular; Muscles; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Reactive Nitrogen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2009 |
Protein and lipid nitration: role in redox signaling and injury.
Topics: Animals; Disease; Humans; Lipid Metabolism; Oxidation-Reduction; Proteins; Signal Transduction; Tyrosine | 2008 |
Quantitative proteome mapping of nitrotyrosines.
Topics: Animals; Chromatography, Liquid; Humans; Peptide Mapping; Peptides; Proteome; Proteomics; Tandem Mass Spectrometry; Tyrosine | 2008 |
Identification of 3-nitrotyrosine-modified brain proteins by redox proteomics.
Topics: Animals; Brain; Humans; Nerve Tissue Proteins; Oxidation-Reduction; Proteomics; Tyrosine | 2008 |
Slot-blot analysis of 3-nitrotyrosine-modified brain proteins.
Topics: Animals; Brain; Humans; Immunoblotting; Nerve Tissue Proteins; Tyrosine | 2008 |
Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection.
Topics: Animals; Body Fluids; Chromatography, Liquid; Humans; Organ Specificity; Tandem Mass Spectrometry; Tyrosine | 2008 |
Use of recombinant iron-superoxide dismutase as a marker of nitrative stress.
Topics: Antibodies; Biomarkers; Enzyme Activation; Immunohistochemistry; Molsidomine; Nitro Compounds; Nitrosation; Oxidative Stress; Recombinant Proteins; Serum Albumin, Bovine; Superoxide Dismutase; Tyrosine | 2008 |
Protein 3-nitrotyrosine in complex biological samples: quantification by high-pressure liquid chromatography/electrochemical detection and emergence of proteomic approaches for unbiased identification of modification sites.
Topics: Animals; Chromatography, High Pressure Liquid; Complex Mixtures; Electrochemistry; Humans; Proteins; Proteomics; Tandem Mass Spectrometry; Tyrosine | 2008 |
Selective fluorogenic derivatization of 3-nitrotyrosine and 3,4-dihydroxyphenylalanine in peptides: a method designed for quantitative proteomic analysis.
Topics: Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorescent Dyes; Humans; Models, Chemical; Peptides; Proteomics; Spectrometry, Fluorescence; Tandem Mass Spectrometry; Tyrosine | 2008 |
Quantitative analysis of biomarkers, drugs and toxins in biological samples by immunoaffinity chromatography coupled to mass spectrometry or tandem mass spectrometry: A focused review of recent applications.
Topics: Animals; Biomarkers; Chromatography, Affinity; Eicosanoids; Humans; Immunosorbent Techniques; Mass Spectrometry; Pharmaceutical Preparations; Toxins, Biological; Tyrosine | 2010 |
Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry.
Topics: Animals; Humans; Proteins; Tandem Mass Spectrometry; Tyrosine | 2012 |
Modulation of vascular sarco/endoplasmic reticulum calcium ATPase in cardiovascular pathophysiology.
Topics: Animals; Antioxidants; Atherosclerosis; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetic Angiopathies; Endothelium, Vascular; Glutathione; Heart Failure; Humans; Mice; Models, Animal; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Protein Processing, Post-Translational; Rabbits; Rats; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Vasodilation | 2010 |
Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease.
Topics: Aldehydes; Alzheimer Disease; Brain; Disease Progression; Humans; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Tyrosine | 2011 |
Nitrative stress in inflammatory lung diseases.
Topics: Animals; Asthma; Humans; Inflammation; Lung; Lung Diseases; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; S-Nitrosothiols; Signal Transduction; Tyrosine | 2011 |
Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: prospects for chemoprevention trials.
Topics: Biomarkers; Chemoprevention; DNA Damage; Glutathione; Humans; Mitochondria; Oxidative Stress; Peroxidase; Saliva; Sjogren's Syndrome; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Proteomic approaches to analyze protein tyrosine nitration.
Topics: Animals; Chromatography; Humans; Oxidation-Reduction; Proteins; Proteomics; Tyrosine | 2013 |
Plant proteins under oxidative attack.
Topics: Animals; Humans; Methionine; Oxidation-Reduction; Plant Proteins; Protein Processing, Post-Translational; Proteomics; Reactive Nitrogen Species; Reactive Oxygen Species; Tandem Mass Spectrometry; Tyrosine | 2013 |
Pituitary adenoma nitroproteomics: current status and perspectives.
Topics: Computational Biology; Humans; Metabolic Networks and Pathways; Nitrites; Oxidative Stress; Pituitary Neoplasms; Proteomics; Reactive Nitrogen Species; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2013 |
Recent methodological advances in the analysis of protein tyrosine nitration.
Topics: Mitochondria; Molecular Structure; Nitrates; Nitric Oxide Synthase; Proteins; Tyrosine | 2013 |
Impairment of calcium ATPases by high glucose and potential pharmacological protection.
Topics: Calcium; Calcium-Transporting ATPases; Diabetes Mellitus; Glucose; Glycation End Products, Advanced; Humans; Lysine; Oxidative Stress; Polymers; Tyrosine | 2013 |
3-Nitrotyrosine: A biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.
Topics: Animals; Autoimmune Diseases; Autoimmunity; Biomarkers; Free Radicals; Humans; Nitrogen; Oxidation-Reduction; Proteins; Tyrosine | 2013 |
An updated meta-analysis of oxidative stress markers in bipolar disorder.
Topics: Biomarkers; Bipolar Disorder; Catalase; Glutathione Peroxidase; Humans; Oxidative Stress; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tyrosine | 2014 |
Tyrosine nitration as mediator of cell death.
Topics: Animals; Cell Death; HSP90 Heat-Shock Proteins; Humans; Inflammation; Peroxynitrous Acid; Reactive Nitrogen Species; Signal Transduction; Superoxide Dismutase; Tyrosine | 2014 |
3-nitrotyrosine modified proteins in atherosclerosis.
Topics: Animals; Atherosclerosis; Biomarkers; Humans; Protein Processing, Post-Translational; Reactive Nitrogen Species; Tyrosine | 2015 |
Analytical approaches to the diagnosis and treatment of aging and aging-related disease: redox status and proteomics.
Topics: Age Factors; Aging; Animals; Biomarkers; Disease Susceptibility; Glutathione; Humans; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Phenotype; Predictive Value of Tests; Protein Carbonylation; Proteins; Proteomics; Risk Factors; Tyrosine | 2015 |
3-Nitrotyrosine quantification methods: Current concepts and future challenges.
Topics: Animals; Humans; Protein Processing, Post-Translational; Tyrosine | 2016 |
Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects.
Topics: Animals; Humans; Mass Spectrometry; Nitrates; Nitrosation; Protein Processing, Post-Translational; Proteins; Proteome; Proteomics; Sensitivity and Specificity; Tyrosine | 2017 |
Biomarkers of oxidative stress in pregnancy complications.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Deoxyguanosine; Diabetes, Gestational; Female; Fetal Growth Retardation; Glycation End Products, Advanced; Humans; Lipoproteins, LDL; Oxidative Stress; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Protein Carbonylation; Tyrosine | 2017 |
Protein Tyrosine Nitration: Role in Aging.
Topics: Age Factors; Aging; Animals; Brain; Humans; Liver; Myocardium; Nitrosative Stress; Oxidative Stress; Protein Conformation; Protein Processing, Post-Translational; Proteomics; Reactive Nitrogen Species; Reactive Oxygen Species; Structure-Activity Relationship; Tyrosine | 2017 |
Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Tyrosine | 2017 |
What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine.
Topics: Chromatography; Humans; Reproducibility of Results; Tandem Mass Spectrometry; Tyrosine | 2017 |
S-Nitrosylation in Regulation of Inflammation and Cell Damage.
Topics: Gene Expression Regulation; Guanylate Cyclase; Humans; Inflammation; Lipids; NF-kappa B; Nitric Oxide; Peroxynitrous Acid; Protein Processing, Post-Translational; Receptors, G-Protein-Coupled; Signal Transduction; Superoxides; Tyrosine | 2018 |
pNitro-Tyr-PseAAC: Predict Nitrotyrosine Sites in Proteins by Incorporating Five Features into Chou's General PseAAC.
Topics: Algorithms; Animals; Humans; Protein Processing, Post-Translational; Proteins; Tyrosine | 2018 |
Peroxynitrite: cellular pathology and implications in autoimmunity.
Topics: Antigen-Antibody Reactions; Antigens; Autoantibodies; Autoimmunity; Biomarkers; DNA; DNA Breaks; Humans; Peroxynitrous Acid; Tyrosine | 2019 |
Advancements in the Analytical Quantification of Nitroxidative Stress Biomarker 3-Nitrotyrosine in Biological Matrices.
Topics: Biomarkers; Humans; Oxidative Stress; Tyrosine | 2020 |
3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biomarkers; Humans; Huntington Disease; Parkinson Disease; Prion Diseases; Tyrosine | 2020 |
3-Nitrotyrosine and related derivatives in proteins: precursors, radical intermediates and impact in function.
Topics: Free Radicals; Humans; Oxidation-Reduction; Protein Processing, Post-Translational; Proteins; Tyrosine | 2020 |
87 trial(s) available for tyrosine and 3-nitrotyrosine
| Article | Year |
|---|---|
Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure.
Topics: Cytokines; Female; Humans; Infant, Newborn; Lipid Peroxidation; Male; Nitric Oxide; Persistent Fetal Circulation Syndrome; Prospective Studies; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Tyrosine | 1998 |
Atorvastatin increases ecNOS levels in human platelets of hyperlipidemic subjects.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Blood Proteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Enzyme Induction; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Pyrroles; Treatment Outcome; Triglycerides; Tyrosine; Vasodilation | 1999 |
Quantification of 3-nitrotyrosine in biological tissues and fluids: generating valid results by eliminating artifactual formation.
Topics: Animals; Artifacts; Gas Chromatography-Mass Spectrometry; Humans; Rats; Reference Standards; Synovial Fluid; Tissue Distribution; Tyrosine | 2000 |
Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation.
Topics: Aged; Animals; Antioxidants; Ascorbic Acid; Atrial Fibrillation; Cardiac Pacing, Artificial; Coronary Artery Bypass; Dogs; Electrophysiology; Female; Heart Atria; Humans; Male; Middle Aged; Multivariate Analysis; Nitrates; Time Factors; Treatment Outcome; Tyrosine | 2001 |
Expression of endomyocardial nitric oxide synthase and coronary endothelial function in human cardiac allografts.
Topics: Acetylcholine; Adolescent; Adult; Aged; Biopsy; Coronary Vessels; Demography; Endothelium, Vascular; Female; Follow-Up Studies; Heart Transplantation; Humans; Longitudinal Studies; Male; Microcirculation; Middle Aged; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Predictive Value of Tests; Prospective Studies; RNA, Messenger; Tyrosine; Vasomotor System | 2001 |
Effect of rebamipide in treatment of Helicobacter pylori-associated duodenal ulcer: attenuation of chemokine expression and nitrosative damage.
Topics: Adult; Alanine; Antioxidants; Chemokine CCL5; Cytokines; Drug Therapy, Combination; Duodenal Ulcer; Enzyme-Linked Immunosorbent Assay; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Interleukin-1; Interleukin-8; Male; Quinolones; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment.
Topics: Blood Glucose; Cardiovascular Diseases; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; Female; Glucose Tolerance Test; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Male; Middle Aged; Oxidative Stress; Postprandial Period; Risk Factors; Simvastatin; Triglycerides; Tyrosine; Vasodilation | 2002 |
Oxidative stress and TGFbeta in kidney-transplanted patients with cyclosporin-induced hypertension. Effect of carvedilol and nifedipine.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Carbazoles; Carvedilol; Cyclosporine; Drug Evaluation; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypertension; Immunosuppressive Agents; Kidney Transplantation; Male; Membrane Proteins; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Postoperative Complications; Propanolamines; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Treatment Outcome; Tyrosine | 2002 |
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Topics: Adult; Blotting, Western; Catalase; Cerebrospinal Fluid Proteins; Female; Glutathione; Glutathione Disulfide; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Recurrence; Reference Values; S-Nitrosothiols; Tyrosine | 2002 |
Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity.
Topics: Acetylcholine; Biopsy; Cell Nucleus; Diabetes Mellitus, Type 2; Disease Progression; Endothelium, Vascular; Enzyme Activation; Female; Forearm; Humans; Immunohistochemistry; Male; Microcirculation; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Platelet Endothelial Cell Adhesion Molecule-1; Poly(ADP-ribose) Polymerases; Polymorphism, Genetic; Predictive Value of Tests; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reference Values; Risk Assessment; Skin; Statistics as Topic; Tyrosine | 2002 |
Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction.
Topics: Adolescent; Adult; Aged; Antioxidants; Autoimmune Diseases; Cells, Cultured; Dexamethasone; Electron Transport; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Glucocorticoids; Humans; Hydrogen Peroxide; Male; Middle Aged; Muscle, Skeletal; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Regional Blood Flow; Superoxides; Tyrosine; Vasodilation; Xanthine Oxidase | 2003 |
Plasma 3-nitrotyrosine and outcome in neonates with severe bronchopulmonary dysplasia after inhaled nitric oxide.
Topics: Administration, Inhalation; Birth Weight; Bronchopulmonary Dysplasia; Chromatography, High Pressure Liquid; Female; Gestational Age; Humans; Infant; Infant, Newborn; Logistic Models; Male; Mass Spectrometry; Nitric Oxide; Risk Factors; Time Factors; Treatment Outcome; Tyrosine; Ventilators, Mechanical | 2003 |
Statins promote potent systemic antioxidant effects through specific inflammatory pathways.
Topics: Antioxidants; Arteriosclerosis; Atorvastatin; Biomarkers; C-Reactive Protein; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Inflammation; Lipoproteins; Male; Middle Aged; Oxidation-Reduction; Prospective Studies; Pyrroles; Reactive Oxygen Species; Signal Transduction; Statistics, Nonparametric; Tyrosine | 2003 |
Leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in association with myocardium-derived nitric oxide and peroxynitrite production for patients undergoing prolonged aortic crossclamping for more than 120 minute
Topics: Adolescent; Adult; Aged; Aorta; Aortic Valve; Blood; Cardioplegic Solutions; Constriction; Female; Heart Arrest, Induced; Humans; Inflammation Mediators; Leukapheresis; Leukocyte Elastase; Male; Middle Aged; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Nitric Oxide; Peroxynitrous Acid; Tyrosine | 2003 |
Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment.
Topics: Body Mass Index; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus; Double-Blind Method; E-Selectin; Electrocardiography; Female; Humans; Hyperglycemia; Hypertriglyceridemia; Hypolipidemic Agents; Intercellular Adhesion Molecule-1; Male; Middle Aged; Oxidative Stress; Postprandial Period; Simvastatin; Triglycerides; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2004 |
Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers.
Topics: Adrenergic Antagonists; Adult; Antioxidants; Carbazoles; Carvedilol; Cells, Cultured; Cross-Over Studies; Dinoprost; Dinoprostone; Double-Blind Method; Endothelial Cells; Humans; Isoprostanes; Lipoproteins, LDL; Male; Metoprolol; Oxidative Stress; Propanolamines; Reactive Nitrogen Species; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Tyrosine | 2004 |
Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein.
Topics: Adult; Atorvastatin; Brachial Artery; Cholesterol; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrroles; RNA, Messenger; Skin; Smoking; Tyrosine; Ultrasonography; Vasodilation | 2004 |
Effect of irbesartan on nitrotyrosine generation in non-hypertensive diabetic patients.
Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Glucose; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Irbesartan; Male; Middle Aged; Placebos; Tetrazoles; Tyrosine | 2004 |
Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization.
Topics: Acetylcholine; Adenosine; Adult; Aged; Cardiac Catheterization; Coronary Circulation; Coronary Disease; Drug Interactions; Endothelin-1; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxygen; Tyrosine; Vasodilator Agents | 2005 |
Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes.
Topics: Adult; Amyloid; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Islet Amyloid Polypeptide; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Placebos; Postprandial Period; Safety; Single-Blind Method; Tyrosine | 2005 |
Inhaled NO and markers of oxidant injury in infants with respiratory failure.
Topics: Administration, Inhalation; Biomarkers; Bronchodilator Agents; Chronic Disease; Female; Glutathione; Humans; Infant, Newborn; Lipid Peroxides; Male; Nitric Oxide; Oxidative Stress; Prospective Studies; Respiratory Distress Syndrome, Newborn; Tyrosine | 2005 |
Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle.
Topics: Aged; Chronic Disease; Electron Transport Complex IV; Energy Metabolism; Exercise; Exercise Test; Exercise Tolerance; Follow-Up Studies; Heart Failure; Humans; Immunohistochemistry; Male; Middle Aged; Muscle, Skeletal; Nitric Oxide Synthase Type II; Oxidative Stress; Oxygen Consumption; Prospective Studies; Tyrosine | 2005 |
Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects.
Topics: Adult; Anemia, Iron-Deficiency; Brachial Artery; Cardiovascular Diseases; Chelating Agents; Double-Blind Method; Endothelium, Vascular; Female; Ferric Compounds; Ferric Oxide, Saccharated; Ferritins; Glucaric Acid; Homocysteine; Humans; Iron; Male; Methionine; Nitroglycerin; Oxidative Stress; Razoxane; Regional Blood Flow; Risk Factors; Transferrin; Tyrosine; Vasodilation | 2006 |
Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support.
Topics: Biomarkers; C-Reactive Protein; Cardiotonic Agents; Case-Control Studies; Cell Adhesion Molecules; Chemokine CCL2; Colorimetry; Cytokines; Dinoprost; Disease Progression; Dobutamine; E-Selectin; Enzyme-Linked Immunosorbent Assay; Exercise Test; Female; Heart Failure; Humans; Inflammation; Interleukin-18; Interleukin-6; Male; Middle Aged; Milrinone; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Tyrosine | 2006 |
Evaluation of tetrahydrobiopterin (BH4) as a potential therapeutic agent to treat erectile dysfunction.
Topics: Adolescent; Adult; Aged; Biopterins; Cross-Over Studies; Dinoprost; Double-Blind Method; Erectile Dysfunction; Humans; Immunohistochemistry; In Vitro Techniques; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Penile Erection; Penis; Tyrosine | 2006 |
Stent-induced neutrophil activation is associated with an oxidative burst in the inflammatory process, leading to neointimal thickening.
Topics: Amidohydrolases; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Coronary Artery Disease; Coronary Restenosis; Coronary Vessels; Female; GPI-Linked Proteins; Humans; Hydrolases; Inflammation; Male; Neutrophil Activation; Neutrophils; Regression Analysis; Respiratory Burst; Stents; Time Factors; Tunica Intima; Tyrosine | 2006 |
Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Female; Glyburide; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipoprotein Lipase; Male; Middle Aged; Oxidative Stress; Pioglitazone; Postprandial Period; Thiazolidinediones; Time Factors; Triglycerides; Tyrosine | 2006 |
Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus.
Topics: Adult; Aged; C-Reactive Protein; Cardiovascular Diseases; Cytokines; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diet, Mediterranean; Follow-Up Studies; Heart; Humans; Middle Aged; Myocardial Infarction; Oxidative Stress; Prognosis; Treatment Outcome; Tyrosine; Wine | 2006 |
Flunisolide decreases exhaled nitric oxide and nitrotyrosine levels in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Anti-Asthmatic Agents; Asthma; Breath Tests; Child; Fluocinolone Acetonide; Humans; Lung; Male; Nitric Oxide; Pilot Projects; Respiratory Function Tests; Single-Blind Method; Tyrosine | 2006 |
Effects of rosuvastatin on 3-nitrotyrosine and aortic stiffness in hypercholesterolemia.
Topics: Adult; Aged; Aorta; Cholesterol; Combined Modality Therapy; Compliance; Diet, Fat-Restricted; Female; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Prospective Studies; Pulsatile Flow; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Treatment Outcome; Tyrosine | 2007 |
Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase.
Topics: Adult; Anion Exchange Resins; Blood Platelets; Cholesterol; Cross-Over Studies; Dose-Response Relationship, Drug; Epichlorohydrin; Fatty Acids, Monounsaturated; Female; Fluvastatin; Glutathione; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Imidazoles; Indoles; Male; Middle Aged; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Platelet Aggregation; Polyisoprenyl Phosphates; Prospective Studies; Resins, Synthetic; Treatment Outcome; Triglycerides; Tyrosine | 2007 |
Pramlintide reduced markers of oxidative stress in the postprandial period in patients with type 2 diabetes.
Topics: Adolescent; Adult; Amyloid; Biomarkers; Blood Glucose; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Insulin Lispro; Islet Amyloid Polypeptide; Male; Middle Aged; Oxidative Stress; Postprandial Period; Single-Blind Method; Tyrosine | 2008 |
Effects of Levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure.
Topics: Aged; Anti-Arrhythmia Agents; Female; Heart Failure; Humans; Hydrazones; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Oxidative Stress; Protein Carbonylation; Pyridazines; Simendan; Stroke Volume; Tyrosine | 2007 |
Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy.
Topics: Adenoidectomy; Arginine; Body Weight; CD40 Ligand; Child; Endothelium, Vascular; Female; Humans; Hyperemia; Hypoxia; Male; Nitric Oxide; Polysomnography; Sleep Apnea, Obstructive; Tonsillectomy; Tyrosine; Vasculitis | 2007 |
Inhaled nitric oxide for modulation of ischemia-reperfusion injury in lung transplantation.
Topics: Administration, Inhalation; Adult; Bronchoalveolar Lavage Fluid; Female; Free Radical Scavengers; Free Radicals; Graft Rejection; Humans; Interleukin-8; Lung; Lung Transplantation; Male; Middle Aged; Neutrophils; Nitric Oxide; Peroxidase; Reperfusion Injury; Tyrosine | 2007 |
Effect of insulin glulisine on microvascular blood flow and endothelial function in the postprandial state.
Topics: Adult; Aged; Blood Flow Velocity; Cross-Over Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypoglycemic Agents; Insulin; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Patient Selection; Postprandial Period; Proinsulin; Tyrosine | 2008 |
Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infants.
Topics: Administration, Inhalation; Biomarkers; Bronchopulmonary Dysplasia; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Logistic Models; Male; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Predictive Value of Tests; Probability; Prognosis; Proteins; Respiratory Distress Syndrome, Newborn; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Survival Analysis; Treatment Outcome; Tyrosine | 2008 |
Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea.
Topics: Adult; Biomarkers; Continuous Positive Airway Pressure; Cyclooxygenase 2; Endothelium, Vascular; Female; Humans; Hypoxia; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Severity of Illness Index; Sleep Apnea, Obstructive; Treatment Outcome; Tyrosine; Vasculitis; Vasodilation; Veins | 2008 |
Reduction of free radicals in multiple sclerosis: effect of glatiramer acetate (Copaxone).
Topics: Adult; Cells, Cultured; Female; Free Radicals; Glatiramer Acetate; Humans; Immunosuppressive Agents; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptides; Superoxides; Tyrosine | 2008 |
Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease.
Topics: C-Reactive Protein; Cardiovascular System; Coronary Disease; Cross-Over Studies; Dinoprost; Double-Blind Method; Fibrinolysis; Humans; Inhalation Exposure; Male; Middle Aged; Particulate Matter; Tyrosine; Vasomotor System | 2008 |
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase.
Topics: Aged; Animals; Antithrombins; Biological Availability; Cattle; Female; Fluorescent Antibody Technique; Hirudins; Humans; Male; Methylation; Middle Aged; Nitric Oxide; Peptide Fragments; Peroxidase; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tyrosine; Vasodilation | 2008 |
Staccato reperfusion prevents reperfusion injury in patients undergoing coronary angioplasty: a 1-year follow-up pilot study.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Biomarkers; Coronary Stenosis; Female; Follow-Up Studies; Humans; Male; Malondialdehyde; Middle Aged; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Pilot Projects; Recovery of Function; Secondary Prevention; Stents; Time Factors; Treatment Outcome; Tyrosine; Ultrasonography; Ventricular Function, Left | 2009 |
Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.
Topics: Administration, Oral; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Endothelium, Vascular; Female; Humans; I-kappa B Proteins; Male; Middle Aged; NADPH Oxidases; NF-kappa B; NF-KappaB Inhibitor alpha; Obesity; Overweight; Oxidative Stress; Salicylates; Tyrosine; Vasodilation | 2009 |
Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus.
Topics: Adiponectin; Adult; Blood Glucose; C-Reactive Protein; Cohort Studies; Coronary Vessels; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipid Metabolism; Male; Middle Aged; Myocardium; Positron-Emission Tomography; Reactive Nitrogen Species; Rosiglitazone; Thiazolidinediones; Tyrosine; von Willebrand Factor | 2009 |
The treatment of multiple sclerosis with inosine.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Brain; CD4 Lymphocyte Count; Central Nervous System; Cross-Over Studies; Cytokines; Disability Evaluation; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Inosine; Kidney Calculi; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Th1 Cells; Th2 Cells; Tyrosine; Uric Acid; Young Adult | 2009 |
Postprandial vascular effects of VIAject compared with insulin lispro and regular human insulin in patients with type 2 diabetes.
Topics: Arginine; Blood Glucose; Blood Vessels; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Insulin Lispro; Male; Microcirculation; Middle Aged; Postprandial Period; Tyrosine | 2010 |
Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans.
Topics: Aged; Angioplasty, Balloon, Coronary; Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Ischemic Postconditioning; Leukocyte Count; Male; Malondialdehyde; Middle Aged; Molsidomine; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tyrosine; Ventricular Function, Left | 2011 |
Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium.
Topics: Aged; Apoptosis; Atherosclerosis; beta Carotene; Cell Count; Cross-Over Studies; Diet, Mediterranean; Dietary Fats; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Humans; Hyperemia; Isoprostanes; Male; Oxidative Stress; Regeneration; Stem Cells; Superoxide Dismutase; Tyrosine | 2011 |
Montmorency cherry juice reduces muscle damage caused by intensive strength exercise.
Topics: Adult; Antioxidants; C-Reactive Protein; Creatine Kinase; Cross-Over Studies; Dietary Supplements; Exercise; Humans; Knee; Male; Muscle Contraction; Muscle, Skeletal; Oxidative Stress; Protein Carbonylation; Prunus; Resistance Training; Tyrosine | 2011 |
The possible protective role of glucagon-like peptide 1 on endothelium during the meal and evidence for an "endothelial resistance" to glucagon-like peptide 1 in diabetes.
Topics: Diabetes Mellitus; Endothelium, Vascular; Female; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Male; Middle Aged; Tyrosine; Vasodilation | 2011 |
Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Antioxidants; Coronary Artery Bypass; Cytokines; Drug Synergism; Female; Hemodynamics; Humans; Inflammation Mediators; Ischemic Postconditioning; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Middle Aged; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Propofol; Tyrosine | 2011 |
Effect of Irbesartan treatment on plasma and urinary markers of protein damage in patients with type 2 diabetes and microalbuminuria.
Topics: Albuminuria; Amino Acids; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Bendroflumethiazide; Biomarkers; Biphenyl Compounds; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Female; Glycation End Products, Advanced; Glycosylation; Humans; Hypertension; Irbesartan; Male; Oxidative Stress; Tetrazoles; Tyrosine | 2012 |
Effect of a fatty meal on inflammatory markers in healthy volunteers with a family history of type 2 diabetes.
Topics: Biomarkers; Case-Control Studies; CD40 Ligand; Cytokines; Diabetes Mellitus, Type 2; Dietary Fats; Endothelium, Vascular; Family; Fasting; Genetic Predisposition to Disease; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipids; Postprandial Period; Reference Values; Risk Factors; RNA, Messenger; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2011 |
3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis.
Topics: Adult; Aged; Area Under Curve; Biomarkers; Citrulline; Early Diagnosis; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methionine; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Psychometrics; ROC Curve; Tyrosine | 2011 |
Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress.
Topics: Adult; Antioxidants; Body Mass Index; Female; Humans; Insulin Resistance; Malondialdehyde; Oxidative Stress; Oxidoreductases; Polycystic Ovary Syndrome; Tyrosine; Uric Acid | 2011 |
Oxidative and nitrosative stress markers in patients on hemodialysis and peritoneal dialysis.
Topics: Adult; Biomarkers; Female; Humans; Male; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Peroxidase; Sulfhydryl Compounds; Tyrosine | 2011 |
Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Antioxidants; Benzimidazoles; Benzoates; Cross-Over Studies; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Japan; Losartan; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Superoxide Dismutase; Telmisartan; Tyrosine | 2011 |
Effect of exercise on vascular superoxide dismutase expression in high-risk pregnancy.
Topics: Adult; Analysis of Variance; Antioxidants; Arginase; Arteries; Endothelium, Vascular; Female; Humans; Muscle Stretching Exercises; Pre-Eclampsia; Pregnancy; Pregnancy, High-Risk; Scavenger Receptors, Class E; Statistics, Nonparametric; Superoxide Dismutase; Transferrin; Tyrosine; Walking | 2011 |
Losartan abolishes oxidative stress induced by intermittent hypoxia in humans.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensin II Type 1 Receptor Blockers; Cross-Over Studies; Deoxyguanosine; Double-Blind Method; Humans; Hypoxia; Losartan; Male; Nitric Oxide; Oxidative Stress; Tyrosine; Uric Acid | 2011 |
The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease.
Topics: Aged; Blood Platelets; Cell Communication; Coronary Disease; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Female; Hemostasis; Humans; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Platelet Aggregation; Reactive Oxygen Species; Tyrosine; Xanthine; Xanthine Oxidase | 2012 |
Oxidative protein damage with carbonyl levels and nitrotyrosine expression after chemotherapy in bone marrow transplantation patients.
Topics: Antilymphocyte Serum; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Male; Melphalan; Oxidation-Reduction; Protein Carbonylation; Tyrosine | 2012 |
Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Doxycycline; Female; Gingiva; Humans; Immunohistochemistry; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Root Planing; Tyrosine | 2013 |
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors.
Topics: Adamantane; Atherosclerosis; Blood Glucose; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cytokines; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Inflammation; Nitriles; Oxidative Stress; Prospective Studies; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Tyrosine; Vildagliptin | 2013 |
Oxidative stress markers in laparoscopic versus open colectomy for cancer: a double-blind randomized study.
Topics: Aged; Analysis of Variance; Biomarkers; Colectomy; Colorectal Neoplasms; Dinoprost; Double-Blind Method; Female; Guanosine; Humans; Laparoscopy; Male; Oxidative Stress; Postoperative Period; Protein Carbonylation; Tyrosine | 2013 |
Mineralocorticoid receptors modulate vascular endothelial function in human obesity.
Topics: Abdominal Fat; Aged; Body Composition; Body Mass Index; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelial Cells; Eplerenone; F2-Isoprostanes; Female; Humans; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Obesity; Oxidative Stress; Receptors, Mineralocorticoid; Spironolactone; Tyrosine; Ultrasonography | 2013 |
Vitamin C further improves the protective effect of GLP-1 on the ischemia-reperfusion-like effect induced by hyperglycemia post-hypoglycemia in type 1 diabetes.
Topics: Adult; Antioxidants; Ascorbic Acid; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Dinoprost; Female; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Inflammation; Inflammation Mediators; Infusions, Parenteral; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Oxidative Stress; Reperfusion Injury; Time Factors; Treatment Outcome; Tyrosine; Vasodilation; Young Adult | 2013 |
Moderate exercise blunts oxidative stress induced by normobaric hypoxic confinement.
Topics: Adult; Advanced Oxidation Protein Products; Atmospheric Pressure; Catalase; Erythropoietin; Exercise; Exercise Test; Glutathione Peroxidase; Heart Rate; Humans; Hypoxia; Male; Malondialdehyde; Oxidative Stress; Oxygen; Physical Exertion; Superoxide Dismutase; Tyrosine; Young Adult | 2014 |
Three months of moderate-intensity exercise reduced plasma 3-nitrotyrosine in rheumatoid arthritis patients.
Topics: Aged; Arthritis, Rheumatoid; Biomarkers; Down-Regulation; England; Exercise Therapy; Female; Humans; Inflammation Mediators; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Physical Fitness; Protein Carbonylation; Severity of Illness Index; Time Factors; Treatment Outcome; Tyrosine | 2014 |
N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.
Topics: Acetylcysteine; Aldehydes; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Double-Blind Method; Energy Metabolism; Glutathione; Male; Maze Learning; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2014 |
Influence of l-carnosine on pro-antioxidant status in elite kayakers and canoeists.
Topics: Antioxidants; Athletes; Biomarkers; Carnosine; Cross-Over Studies; Dietary Supplements; Dinoprost; Glutathione; Humans; Hydrogen Peroxide; Lactic Acid; Male; Muscle, Skeletal; Nitric Oxide; Oxidative Stress; Physical Endurance; Poland; Superoxide Dismutase; Time Factors; Tyrosine; Young Adult | 2014 |
High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anaemia.
Topics: Anemia, Sickle Cell; Enzyme Activation; Erythrocyte Deformability; Erythrocytes; Female; Humans; Male; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Spectrin; Tyrosine | 2015 |
Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration.
Topics: Analysis of Variance; Animals; Animals, Newborn; Asphyxia Neonatorum; Fluorescence; Hemodynamics; Luminescent Measurements; Meconium Aspiration Syndrome; Microspheres; Pulmonary Gas Exchange; Resuscitation; Sheep; Sheep Diseases; Suction; Trachea; Tyrosine | 2015 |
Ascorbic acid supplementation diminishes microparticle elevations and neutrophil activation following SCUBA diving.
Topics: Ascorbic Acid; Biomarkers; Blood Platelets; Cell-Derived Microparticles; Cross-Over Studies; Decompression Sickness; Dietary Supplements; Diving; Embolism, Air; Humans; Male; Neutrophil Activation; Neutrophils; Syndecan-1; Time Factors; Treatment Outcome; Tyrosine; Ultrasonography | 2015 |
Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric "Live High-Train Low".
Topics: Adult; Advanced Oxidation Protein Products; Humans; Hypoxia; Male; Oxidative Stress; Physical Fitness; Superoxide Dismutase; Tyrosine; Uric Acid | 2015 |
Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load.
Topics: Adult; Blood Glucose; Cardiovascular Diseases; Endoplasmic Reticulum Stress; Endothelium, Vascular; Female; Humans; Hyperglycemia; Insulin; Male; Oxidative Stress; Postprandial Period; Taurochenodeoxycholic Acid; Thiobarbituric Acid Reactive Substances; Tyrosine; Young Adult | 2016 |
Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: The PREDIMED study.
Topics: Aged; Aged, 80 and over; Biomarkers; Catalase; Cholesterol; Diet, Fat-Restricted; Diet, Mediterranean; Female; Follow-Up Studies; Humans; Male; Metabolic Syndrome; Middle Aged; Nutrition Assessment; Nuts; Olive Oil; Patient Compliance; Peroxidase; Superoxide Dismutase; Surveys and Questionnaires; Tyrosine; Xanthine Oxidase | 2016 |
Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial.
Topics: Adult; Antioxidants; Azoles; Brachial Artery; Case-Control Studies; Cross-Over Studies; Diabetes Mellitus; Dinoprost; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Glutathione; Humans; Isoindoles; Male; Methacholine Chloride; Middle Aged; Organoselenium Compounds; Oxidative Stress; Parasympathomimetics; Plethysmography; Tyrosine; Ultrasonography; Vasodilation | 2016 |
Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Inhaled Nitric Oxide.
Topics: Administration, Inhalation; Albumins; Analysis of Variance; Case-Control Studies; Chemokines; Demography; Female; Humans; Infant, Newborn; Infant, Premature; Inflammation Mediators; Male; Nitric Oxide; Nitrites; Sphingomyelin Phosphodiesterase; Suction; Trachea; Tyrosine | 2017 |
Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation.
Topics: Aged; Antioxidants; Atrial Fibrillation; Biomarkers; Blood Glucose; C-Reactive Protein; Catheter Ablation; Cholesterol, HDL; Cholesterol, LDL; Cytokines; Double-Blind Method; Female; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Peroxynitrous Acid; Postoperative Care; Recurrence; Thioctic Acid; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
The effects of polyunsaturated fatty acids and antioxidant vitamins on atrial oxidative stress, nitrotyrosine residues, and connexins following extracorporeal circulation in patients undergoing cardiac surgery.
Topics: Antioxidants; Cardiac Surgical Procedures; Connexins; Extracorporeal Circulation; Fatty Acids, Unsaturated; Female; Heart Atria; Humans; Male; Oxidative Stress; Tyrosine; Vitamins | 2017 |
The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Blood Glucose; Deoxyguanosine; Diabetic Nephropathies; Female; Glutathione; Hemoglobins; Humans; Insulin; Insulin Infusion Systems; Interleukin-6; Male; Middle Aged; Oxidative Stress; Superoxide Dismutase; Tyrosine | 2018 |
NOD2 expression, DNA damage and oxido-inflammatory status in atopic bronchial asthma: Exploring their nexus to disease severity.
Topics: Adult; Asthma; DNA Damage; Female; Gene Expression Regulation, Enzymologic; Hexosaminidases; Humans; Immunoglobulin E; Inflammation; Interleukin-17; Interleukin-8; Leukocytes, Mononuclear; Male; Middle Aged; Nod2 Signaling Adaptor Protein; Oxidation-Reduction; Oxidative Stress; Severity of Illness Index; Tyrosine | 2018 |
Association of the Tyrosine/Nitrotyrosine pathway with death or ICU admission within 30 days for patients with community acquired pneumonia.
Topics: Aged; Aged, 80 and over; Cohort Studies; Community-Acquired Infections; Female; Follow-Up Studies; Humans; Intensive Care Units; Male; Metabolic Networks and Pathways; Middle Aged; Mortality; Patient Admission; Pneumonia; Prognosis; Risk Factors; Switzerland; Time Factors; Tyrosine | 2018 |
Nitrotyrosine (NT), a Nitrosative Stress Biomarker, Plasma Concentrations in Gallstone Disease and Cancer Patients.
Topics: Adult; Aged; Biomarkers; Cholecystectomy, Laparoscopic; Female; Gallstones; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Humans; Male; Middle Aged; Nitrosative Stress; Pain Management; Pain Measurement; Postoperative Period; Reactive Oxygen Species; Tyrosine | 2019 |
Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans.
Topics: Acetophenones; Adult; Antioxidants; Biomarkers; Blood Flow Velocity; Cyclic N-Oxides; Endothelial Cells; Female; Forearm; Humans; Male; Microcirculation; Middle Aged; NADP; Oxidative Stress; Reactive Oxygen Species; Skin; Sodium Chloride, Dietary; Spin Labels; Time Factors; Tyrosine; Vasodilation; Young Adult | 2019 |
Consuming decaffeinated coffee with milk and sugar added before a high-glycaemic index meal improves postprandial glycaemic and insulinaemic responses in healthy adults.
Topics: Adult; Animals; Blood Glucose; Caffeine; Coffee; Cross-Over Studies; Dietary Sugars; Drinking; Female; Glucagon-Like Peptide 1; Glycemic Index; Healthy Volunteers; Humans; Insulin; Male; Meals; Middle Aged; Milk; Postprandial Period; Tyrosine; Young Adult | 2020 |
Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men.
Topics: Aged; Arginine; Athletes; Body Mass Index; Cryotherapy; Exercise; Humans; Interleukins; Male; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Physical Endurance; Tyrosine | 2021 |
3240 other study(ies) available for tyrosine and 3-nitrotyrosine
| Article | Year |
|---|---|
Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin.
Topics: Animals; Brain Chemistry; Cattle; Fluorescence; Humans; Peptide Synthases; Staining and Labeling; Tubulin; Tyrosine | 2010 |
Estimation of nitrotyrosine derivatives in nitrosated foods.
Topics: Chromatography, Ion Exchange; Meat; Meat Products; Nitrites; Spectrophotometry; Tyrosine | 1979 |
The utility of the nitrotyrosine chromophore as a spectroscopic probe in troponin C and modulator protein.
Topics: Animals; Brain Chemistry; Calcium; Calmodulin; Carrier Proteins; Cattle; Circular Dichroism; Kinetics; Muscle Proteins; Muscles; Myocardium; Nerve Tissue Proteins; Protein Binding; Protein Conformation; Rabbits; Spectrophotometry; Tetranitromethane; Troponin; Tyrosine | 1979 |
Non-specific influence of chemical modification upon the properties of antithrombin III:modification of carboxyl groups.
Topics: Antithrombin III; Carbodiimides; Chromatography, Affinity; CME-Carbodiimide; Heparin; Humans; Hydrogen-Ion Concentration; Spectrometry, Mass, Fast Atom Bombardment; Thrombin; Tyrosine | 1992 |
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.
Topics: Animals; Binding Sites; Cattle; Erythrocytes; Hydrogen-Ion Concentration; Kinetics; Lasers; Nitrates; Nitric Oxide; Protein Conformation; Spectrum Analysis, Raman; Superoxide Dismutase; Tyrosine | 1992 |
Uptake and metabolism of iodine is crucial for the development of thyroiditis in obese strain chickens.
Topics: Amitrole; Animals; Chickens; Immunotherapy, Adoptive; Iodine; Obesity; Perchlorates; Potassium; Potassium Compounds; Propylthiouracil; Thyroid Gland; Thyroiditis, Autoimmune; Thyrotropin; Tyrosine | 1991 |
The interaction of nitrotyrosine-83 plastocyanin with cytochromes f and c: pH dependence and the effect of an additional negative charge on plastocyanin.
Topics: Cytochrome c Group; Cytochromes; Cytochromes f; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Oxidation-Reduction; Plastocyanin; Protein Conformation; Tyrosine | 1991 |
Nitrotyrosine as a new marker for endogenous nitrosation and nitration.
Topics: Animals; Blood Proteins; Chromatography, Gas; Humans; Nitrates; Nitroso Compounds; Tyrosine | 1991 |
Anthranilamide and nitrotyrosine as a donor-acceptor pair in internally quenched fluorescent substrates for endopeptidases: multicolumn peptide synthesis of enzyme substrates for subtilisin Carlsberg and pepsin.
Topics: Amino Acid Sequence; Fluorescence; Hydrolysis; Molecular Sequence Data; ortho-Aminobenzoates; Pepsin A; Peptides; Substrate Specificity; Subtilisins; Tyrosine | 1991 |
Salmonella/mammalian microsome assay with tetranitromethane and 3-nitro-L-tyrosine.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; In Vitro Techniques; Methane; Microsomes; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium; Tetranitromethane; Tyrosine | 1990 |
Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins.
Topics: Animals; Blood Proteins; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Male; Nitrosamines; Nitrosation; Rats; Tetranitromethane; Tyrosine | 1990 |
Cell culture study on neurofibromatosis.
Topics: Cell Count; Cell Division; Cells, Cultured; Humans; Neurofibromatosis 1; Radiography; Skin; Tyrosine | 1987 |
Chemical modification of human alpha 1-proteinase inhibitor by tetranitromethane. Structure-function relationship.
Topics: alpha 1-Antitrypsin; Amino Acids; Blood Proteins; Chromatography, DEAE-Cellulose; Humans; Macromolecular Substances; Methane; Peptide Fragments; Protease Inhibitors; Structure-Activity Relationship; Tetranitromethane; Tyrosine | 1987 |
Nitro-tyrosine as promoter of free radical damage in a DNA model system.
Topics: Ascorbic Acid; Cations, Divalent; Copper; DNA Damage; Free Radicals; Oxidation-Reduction; Tyrosine | 1986 |
Properties of some 3-nitrotyrosyl elapid venom cardiotoxins.
Topics: Animals; Chemical Phenomena; Chemistry; Circular Dichroism; Cobra Cardiotoxin Proteins; Drug Synergism; Elapid Venoms; Guinea Pigs; Hemolysis; Mice; Oxidation-Reduction; Phospholipases A; Structure-Activity Relationship; Tyrosine | 1987 |
In vivo formation of diiodotyrosine by extrathyroidal thyroxine ether-link cleavage and effects of mononitrotyrosine on this pathway in the rat.
Topics: Animals; Diiodotyrosine; Female; Metabolic Clearance Rate; Radioimmunoassay; Rats; Rats, Inbred Strains; Thyroidectomy; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse; Tyrosine | 1986 |
Effects of 3-nitro-L-tyrosine on thyroid function in the rat: an experimental model for the dehalogenase defect.
Topics: Administration, Oral; Animals; Blood Proteins; Chromatography, Paper; Diet; Diiodotyrosine; Disease Models, Animal; Hydrolases; Hypothyroidism; Injections, Intraperitoneal; Iodides; Iodine; Iodine Isotopes; Male; Monoiodotyrosine; Nitro Compounds; Organ Size; Protein Binding; Radioimmunoassay; Rats; Rats, Inbred Strains; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Tyrosine | 1971 |
Essential tyrosyl residues of human placental alkaline phosphatase.
Topics: Alkaline Phosphatase; Female; Humans; Kinetics; Methane; Phosphates; Placenta; Pregnancy; Protein Binding; Spectrophotometry; Tetranitromethane; Tyrosine | 1984 |
Selective nitration of tyrosines-26 and -64 in bacteriorhodopsin with tetranitromethane.
Topics: Bacteriorhodopsins; Carotenoids; Chemical Phenomena; Chemistry; Chymotrypsin; Halobacterium; Hydrogen-Ion Concentration; Methane; Photochemistry; Spectrophotometry; Structure-Activity Relationship; Tetranitromethane; Tyrosine | 1984 |
Effects of iodotyrosine deiodinase inhibition on serum concentrations and turnover of diiodotyrosine (DIT) and thyroxine (T4) in the rat.
Topics: Animals; Diiodotyrosine; Female; Iodide Peroxidase; Kinetics; Metabolic Clearance Rate; Peroxidases; Rats; Rats, Inbred Strains; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse; Tyrosine | 1983 |
The pathophysiology of neurofibromatosis. I. Resistance in vitro to 3-nitrotyrosine as an expression of the mutation.
Topics: Adolescent; Adult; Cell Division; Cell Survival; Cells, Cultured; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Resistance; Female; Fibroblasts; Humans; Infant, Newborn; Male; Middle Aged; Neurofibroma; Neurofibromatosis 1; Skin; Tyrosine | 1980 |
Reaction of nitrite with tyrosine residues in digestive enzymes.
Topics: Animals; Drug Interactions; Nitrites; Rats; Sodium Nitrite; Stomach; Tyrosine | 1981 |
Slow structural changes shown by the 3-nitrotyrosine-237 residue in pig heart [Tyr(3NO2)237] lactate dehydrogenase.
Topics: Animals; Kinetics; L-Lactate Dehydrogenase; Myocardium; NAD; Oxamic Acid; Protein Conformation; Spectrophotometry; Swine; Temperature; Tyrosine | 1982 |
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Oxidoreductases; Animals; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Male; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide Synthase; Tyrosine | 1995 |
Reactive species in ischemic rat lung injury: contribution of peroxynitrite.
Topics: Animals; Arginine; Immunohistochemistry; Ischemia; Lung; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Perfusion; Pressure; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Staining and Labeling; Tyrosine | 1995 |
Modification of a specific tyrosine enables tracing of the end-to-end distance during apomyoglobin folding.
Topics: Animals; Apoproteins; Hydrogen-Ion Concentration; Mass Spectrometry; Myoglobin; Protein Conformation; Protein Folding; Tyrosine | 1995 |
1-Methylguanosine deficiency of tRNA influences cognate codon interaction and metabolism in Salmonella typhimurium.
Topics: 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases; Amino Acid Transport Systems, Neutral; Amino Acids; Bacterial Proteins; beta-Galactosidase; Carbon; Codon; Drug Resistance, Microbial; Enzyme Induction; Gene Expression Regulation, Bacterial; Guanosine; Membrane Proteins; Membrane Transport Proteins; Mutation; Operon; Peptide Chain Elongation, Translational; RNA, Messenger; RNA, Transfer, Amino Acyl; Salmonella typhimurium; Suppression, Genetic; tRNA Methyltransferases; Tyrosine | 1995 |
Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells.
Topics: Animals; Dihydroxyphenylalanine; Molsidomine; Nitrates; Oxidation-Reduction; PC12 Cells; Rats; Tyrosine | 1995 |
3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice.
Topics: Animals; Humans; Hydroxybenzoates; Hydroxyl Radical; Mice; Mice, Transgenic; Neurotoxins; Nitro Compounds; Propionates; Reference Values; Superoxide Dismutase; Tyrosine | 1995 |
Peroxynitrite-mediated oxidative protein modifications.
Topics: Animals; Cysteine; Electrophoresis, Polyacrylamide Gel; Fluorescence; Hydrogen-Ion Concentration; Male; Nitrates; Oxidation-Reduction; Oxidative Stress; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Tryptophan; Tyrosine | 1995 |
Electrochemical modification of lysozyme: anodic reaction of tyrosine residues.
Topics: Alkalies; Amino Acid Sequence; Buffers; Cyanogen Bromide; Electrodes; Electrolysis; Fluorescein-5-isothiocyanate; Molecular Sequence Data; Muramidase; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Sequence Analysis; Tyrosine | 1994 |
Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.
Topics: Adolescent; Animals; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Infant; Infant, Newborn; Lung; Male; Microtomy; Nitrates; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome, Newborn; Tyrosine | 1994 |
Nitration of tyrosine residues in protein-nucleic acid complexes.
Topics: Binding Sites; DNA; DNA-Binding Proteins; Indicators and Reagents; Peptide Mapping; Tetranitromethane; Tyrosine | 1994 |
Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients.
Topics: Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Humans; Nitric Oxide; Spectrophotometry, Ultraviolet; Synovial Fluid; Tyrosine | 1994 |
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.
Topics: Cell Nucleus; Coronary Artery Disease; Coronary Vessels; Humans; Immunoenzyme Techniques; Macrophages; Middle Aged; Nitric Oxide; Oxidation-Reduction; Tyrosine | 1994 |
Nitration of tyrosyl-residues from extra- and intracellular proteins in human whole blood.
Topics: Blood Proteins; Calcimycin; Humans; Ionophores; Kinetics; Neutrophils; Nitrates; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1995 |
Nitration of tyrosine by hydrogen peroxide and nitrite.
Topics: Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxylation; Inflammation; Iron; Nitrates; Oxidative Stress; Salicylates; Salicylic Acid; Sodium Nitrite; Tyrosine | 1995 |
Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Axons; Humans; Immunohistochemistry; Motor Neurons; Phosphorylation; Protein-Tyrosine Kinases; Spinal Cord; Superoxide Dismutase; Superoxides; Tyrosine | 1995 |
Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process?
Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Male; Muscle, Skeletal; Nitrates; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Tyrosine | 1996 |
Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo.
Topics: Adenosine Triphosphate; Animals; Corpus Striatum; Electrophysiology; Gentisates; Hydroxybenzoates; Indazoles; Lactates; Lactic Acid; Male; Neurons; Neurotoxins; Nitric Oxide Synthase; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Tyrosine | 1995 |
Nitric oxide production and perivascular nitration in brain after carbon monoxide poisoning in the rat.
Topics: Animals; Arginine; Blood Platelets; Brain; Carbon Monoxide Poisoning; Electron Spin Resonance Spectroscopy; Immunohistochemistry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Tyrosine | 1996 |
Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.
Topics: Animals; Free Radicals; Malonates; Mice; Mice, Knockout; Neostriatum; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Thallium; Tyrosine | 1996 |
Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitrite.
Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Kinetics; Nitrates; Oxidation-Reduction; Time Factors; Tyrosine | 1996 |
Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline.
Topics: Acetaminophen; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Flufenamic Acid; Free Radical Scavengers; Humans; Mesalamine; Nitrates; Pancreatic Elastase; Penicillamine; Phenylbutazone; Tetracycline; Tyrosine | 1996 |
Increased 3-nitrotyrosine in brains of Apo E-deficient mice.
Topics: Animals; Apolipoproteins E; Biomarkers; Brain Chemistry; Free Radical Scavengers; Free Radicals; Gentisates; Hydroxybenzoates; Mice; Mice, Inbred C57BL; Oxidative Stress; Salicylates; Salicylic Acid; Tyrosine | 1996 |
Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.
Topics: Arginine; Bacteria; Blood Bactericidal Activity; Blotting, Western; Enzyme Induction; Enzyme Inhibitors; Humans; In Situ Hybridization; Interferon-gamma; Interleukin-1; Monokines; Neutrophils; Nitric Oxide Synthase; omega-N-Methylarginine; Peroxidase; Phagocytosis; RNA, Messenger; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 1996 |
Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action.
Topics: Adult; Drug Residues; Female; Fetal Growth Retardation; Humans; Immunohistochemistry; Nitrates; Placenta; Pre-Eclampsia; Pregnancy; Tyrosine | 1996 |
Do human atherosclerotic lesions contain nitrotyrosine?
Topics: Antibody Specificity; Arteriosclerosis; Blotting, Western; Chromatography, High Pressure Liquid; Humans; Immune Sera; Tyrosine | 1996 |
Gene expression and cellular sources of inducible nitric oxide synthase during tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogens; DNA Primers; Enzyme Induction; Female; Keratinocytes; Mice; Mice, Inbred Strains; Models, Biological; Nitric Oxide Synthase; Polymerase Chain Reaction; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1996 |
Protective effects of tirilazad mesylate in a cellular model of peroxynitrite toxicity.
Topics: Aminoisobutyric Acids; Animals; Biomarkers; Cells, Cultured; Cerebellum; Emulsions; Free Radical Scavengers; Lipid Peroxides; Nitrates; Pregnatrienes; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Catechin; Cattle; Deoxyguanosine; DNA; Free Radical Scavengers; Nitrates; Oxidation-Reduction; Tea; Tyrosine | 1996 |
Identification of 3-nitro-L-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain.
Topics: Aged; Biomarkers; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Superoxides; Tyrosine | 1996 |
8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; Male; Mice; Mice, Hairless; Pyrimidine Dimers; Skin; Skin Neoplasms; Tyrosine; Ultraviolet Rays | 1996 |
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.
Topics: Amino Acid Sequence; Analysis of Variance; Blotting, Western; Graft Rejection; Humans; Immunohistochemistry; Kidney; Kidney Transplantation; Models, Biological; Nitrates; Peptide Fragments; Superoxide Dismutase; Transplantation, Homologous; Tyrosine | 1996 |
Nitrotyrosine attenuates the hemodynamic effects of adrenoceptor agonists in vivo: relevance to the pathophysiology of peroxynitrite.
Topics: Adrenergic Agonists; Animals; Arginine Vasopressin; Hemodynamics; Male; Nitrates; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants.
Topics: alpha 1-Antitrypsin; Antioxidants; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Lipid Peroxidation; Nitrates; Oxidation-Reduction; Oxidative Stress; Pancreatic Elastase; Synovial Fluid; Tyrosine | 1996 |
Effect of 2,3-dimercaptosuccinic acid on nephrosclerosis in the Dahl rat. I. Role of reactive oxygen species.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chelating Agents; Chromatography, High Pressure Liquid; Immunohistochemistry; Male; Malondialdehyde; Nephrosclerosis; Oxidants; Rats; Rats, Inbred Strains; Reactive Oxygen Species; Renal Artery; Sodium, Dietary; Succimer; Tyrosine | 1996 |
Identification of nitration sites on surfactant protein A by tandem electrospray mass spectrometry.
Topics: Amino Acid Sequence; Humans; Mass Spectrometry; Molecular Sequence Data; Nitrates; Peptide Fragments; Peptide Mapping; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Tyrosine | 1996 |
Sensitive determination of nitrotyrosine in human plasma by isocratic high-performance liquid chromatography.
Topics: 4-Chloro-7-nitrobenzofurazan; Biomarkers; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 1996 |
The peroxynitrite product 3-nitro-L-tyrosine attenuates the hemodynamic responses to angiotensin II in vivo.
Topics: Anesthesia; Angiotensin II; Animals; Hemodynamics; Male; Nitrates; Pentobarbital; Rats; Rats, Sprague-Dawley; Tyrosine; Vasoconstrictor Agents | 1996 |
NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Male; Nerve Growth Factors; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Formation of nitrosyl hemoglobin and nitrotyrosine during murine leishmaniasis.
Topics: Animals; Disease Models, Animal; Female; Hemoglobins; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide; Photobiology; Tyrosine | 1996 |
Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima.
Topics: Arteries; Arteriosclerosis; Free Radicals; Humans; In Vitro Techniques; Lipoproteins, LDL; Nitrogen; Oxidation-Reduction; Serum Albumin, Bovine; Tyrosine | 1997 |
Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis.
Topics: Enzyme Induction; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Muscle Fibers, Skeletal; Muscular Diseases; Myositis, Inclusion Body; Neurons; Nitric Oxide Synthase; Oxidative Stress; Tyrosine | 1996 |
Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis.
Topics: Animals; Apoptosis; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Enzyme Induction; Female; Isoenzymes; Mice; Myelin Basic Protein; Myelin Sheath; Nitric Oxide; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Apoptotic cell death of neutrophils in development of skin lesions of patients with anaphylactoid purpura.
Topics: Adolescent; Adult; Aged; Anaphylaxis; Apoptosis; Cell Nucleus; Child; Child, Preschool; DNA Fragmentation; Endothelium, Vascular; Female; Humans; Interleukin-8; Leukocyte Count; Male; Middle Aged; Neutrophils; Nitric Oxide Synthase; Purpura; Skin Diseases; Tyrosine | 1997 |
Widespread peroxynitrite-mediated damage in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Entorhinal Cortex; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Nitrates; Oxidative Stress; Tyrosine | 1997 |
Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection.
Topics: Animals; Blood Proteins; Cell Line; Chromatography, High Pressure Liquid; Electrochemistry; Gas Chromatography-Mass Spectrometry; Inflammation; Macrophage Activation; Male; Nitrates; Nitric Oxide; Rats; Rats, Inbred F344; Tyrosine; Zymosan | 1997 |
Thiourea and dimethylthiourea inhibit peroxynitrite-dependent damage: nonspecificity as hydroxyl radical scavengers.
Topics: alpha 1-Antitrypsin; Enzyme Inhibitors; Free Radical Scavengers; Hydroxyl Radical; Nitrates; Thiourea; Tyrosine | 1997 |
The kinetics and regulation of the induction of type II nitric oxide synthase and nitric oxide in human fetal glial cell cultures.
Topics: Brain; Cells, Cultured; Cyclic GMP; Enzyme Induction; Gene Expression Regulation, Developmental; Humans; Interferon-gamma; Interleukin-1; Isoenzymes; Kinetics; NADPH Dehydrogenase; Neuroglia; Nitric Oxide; Nitric Oxide Synthase; Tyrosine | 1997 |
Absence of the inducible form of nitric oxide synthase in the brains of patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Biomarkers; Cells, Cultured; Child, Preschool; Enzyme Induction; Female; Humans; Isoenzymes; Male; Middle Aged; Models, Neurological; Multiple Sclerosis; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; RNA, Messenger; Superoxides; Tyrosine | 1997 |
Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Free Radicals; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitric Oxide; Shock, Septic; Superoxides; Tyrosine | 1997 |
Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions.
Topics: Animals; Benzoates; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Free Radical Scavengers; Imidazoles; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitrites; Serum Albumin, Bovine; Swine; Tyrosine | 1997 |
Nitrotyrosine bound to beta-VLDL-apoproteins: a biomarker of peroxynitrite formation in experimental atherosclerosis.
Topics: Animals; Arteriosclerosis; Biomarkers; Blood Proteins; Cholesterol; Hypercholesterolemia; Lipoproteins, VLDL; Male; Nitrates; Rabbits; Triglycerides; Tyrosine | 1997 |
Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells.
Topics: Animals; Cell Count; Diabetes Mellitus, Type 1; Female; Islets of Langerhans; Leukocytes; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Nitrates; Tyrosine | 1997 |
Sensitivity of human hepatocytes in culture to reactive nitrogen intermediates.
Topics: Cells, Cultured; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Molsidomine; Nitrites; Nitrogen; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1997 |
Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis.
Topics: Endothelium, Vascular; Epithelium; Female; Humans; Immunohistochemistry; In Situ Hybridization; Lung; Macrophages, Alveolar; Male; Middle Aged; Nitrates; Oxidants; Pulmonary Fibrosis; Tyrosine | 1997 |
Nitrotyrosine formation, apoptosis, and oxidative damage: relationships to nitric oxide production in SJL mice bearing the RcsX tumor.
Topics: Animals; Apoptosis; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Female; Immunohistochemistry; Lymph Nodes; Lymphoma; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Spleen; Tyrosine | 1997 |
Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Brain; Endothelium, Vascular; Enzyme Induction; Humans; Immunohistochemistry; Motor Neurons; Nitric Oxide Synthase; Reference Values; Spinal Cord; Staining and Labeling; Superoxide Dismutase; Tyrosine | 1997 |
Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric oxide.
Topics: Actins; Animals; Antibodies; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; Hydrazones; Molecular Weight; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Serum Albumin; Spermine; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Free and protein-associated nitrotyrosine formation following rat liver preservation and transplantation.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Free Radicals; Humans; Liver; Liver Transplantation; Nitrates; Organ Preservation; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 1997 |
Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite.
Topics: Adolescent; Autopsy; Child; Child, Preschool; Densitometry; Female; Humans; Infant; Infant, Newborn; Male; Myocarditis; Nitrates; Nitrosation; Retrospective Studies; Sepsis; Tyrosine | 1997 |
Nitric oxide inhibits neutrophil beta 2 integrin function by inhibiting membrane-associated cyclic GMP synthesis.
Topics: Animals; Atrial Natriuretic Factor; CD18 Antigens; Cell Adhesion; Cell Degranulation; Cyclic GMP; Glutathione; Guanylate Cyclase; Hydrazines; Male; Neutrophils; Nitric Oxide; Nitrogen Oxides; Protein Kinase C; Rats; Rats, Wistar; Respiratory Burst; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Extensive peroxynitrite activity during progressive stages of central nervous system inflammation.
Topics: Animals; Antibody Specificity; Brain; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Free Radicals; Immunohistochemistry; Lipid Peroxidation; Mice; Mice, Inbred Strains; Neuritis, Autoimmune, Experimental; Neurons; Nitrates; Nitric Oxide; Spinal Cord; Staining and Labeling; Tyrosine | 1997 |
Presence of inducible nitric oxide synthase, nitrotyrosine, CD68, and CD14 in the small intestine in celiac disease.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biopsy; Celiac Disease; Child; Child, Preschool; Enzyme Induction; Female; Humans; Immunoenzyme Techniques; Infant; Intestine, Small; Lipopolysaccharide Receptors; Male; Nitric Oxide Synthase; Tyrosine | 1997 |
Peroxynitrite-mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometry.
Topics: Chromatography, Liquid; Enkephalin, Leucine; Gas Chromatography-Mass Spectrometry; Hemoglobins; HIV Envelope Protein gp120; Mass Spectrometry; Nitrates; Peptide Fragments; Trimethylsilyl Compounds; Tyrosine | 1997 |
What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
Topics: Biomarkers; Free Radicals; Humans; Molecular Structure; Nitrates; Nitric Oxide; Nitrogen Dioxide; Nitrous Acid; Peroxidase; Superoxides; Tyrosine | 1997 |
Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite.
Topics: Animals; Cattle; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Humans; Intramolecular Oxidoreductases; Nitrates; Nitric Oxide; Superoxides; Tyrosine | 1997 |
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Binding Sites; Corpus Striatum; Dizocilpine Maleate; DNA Fragmentation; Excitatory Amino Acid Antagonists; Hydroxyl Radical; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nitric Oxide Synthase; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tyrosine | 1997 |
Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages.
Topics: Bronchoalveolar Lavage; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Gene Expression; Humans; Macrophages, Alveolar; Mycobacterium bovis; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; RNA, Messenger; Tyrosine | 1997 |
Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electrochemistry; Female; Interleukin-1; Neuroglia; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine | 1997 |
Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure.
Topics: Animals; Arginine; Carbon Monoxide; Cattle; Cell Survival; Cells, Cultured; Chromium; Endothelium, Vascular; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidants; Oxidation-Reduction; Oxygen Consumption; Sulfhydryl Compounds; Tetrazolium Salts; Thiazoles; Tyrosine | 1997 |
Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Copper; Heme Oxygenase (Decyclizing); Humans; Lipid Peroxidation; Malondialdehyde; Mice; Mice, Mutant Strains; Mice, Transgenic; Motor Neuron Disease; Point Mutation; Protein Binding; Spinal Cord; Superoxide Dismutase; Tyrosine; Zinc | 1997 |
Immunohistochemically detected protein nitration indicates sites of renal nitric oxide release in Goldblatt hypertension.
Topics: Animals; Blood Vessels; Hypertension, Renovascular; Immunohistochemistry; Juxtaglomerular Apparatus; Kidney; Male; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tissue Distribution; Tyrosine | 1997 |
Heat shock protein induction protects human respiratory epithelium against nitric oxide-mediated cytotoxicity.
Topics: Adenosine Triphosphate; Bronchi; Cell Line; Cell Survival; Epithelial Cells; Epithelium; Heat-Shock Proteins; Heat-Shock Response; HSP70 Heat-Shock Proteins; Humans; Nitric Oxide; Tyrosine | 1997 |
Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal; Family Health; Female; Humans; Male; Middle Aged; Motor Neurons; Mutation; Nissl Bodies; Nitrophenols; Oxidative Stress; Phenylacetates; Spinal Cord; Superoxide Dismutase; Tyrosine | 1997 |
3-Nitrotyrosine in human serum albumin and low density lipoproteins.
Topics: Humans; Lipoproteins, LDL; Nitrates; Oxidants; Serum Albumin; Tyrosine | 1997 |
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Topics: Animals; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Free Radical Scavengers; Immunoenzyme Techniques; Inflammation; Male; Melatonin; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Pleurisy; Rats; Rats, Sprague-Dawley; Tyrosine | 1997 |
Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Antineoplastic Agents; Creatine; Creatinine; Disease Models, Animal; Energy Metabolism; Free Radicals; Huntington Disease; Lactates; Male; Malonates; Neostriatum; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Sprague-Dawley; Tyrosine | 1998 |
Plasma 3-nitrotyrosine in cigarette smokers.
Topics: Adult; Aged; Antioxidants; Chromans; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Smoking; Tyrosine | 1997 |
Evidence for the production of peroxynitrite in inflammatory CNS demyelination.
Topics: Acute Disease; Animals; Chronic Disease; Encephalomyelitis, Autoimmune, Experimental; Female; Immunohistochemistry; Mice; Mice, Inbred Strains; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Recurrence; Remission Induction; Serum Albumin, Bovine; Spinal Cord; Tyrosine | 1997 |
Low toxicity of nitric oxide against endothelial cells under physiological oxygen partial pressures.
Topics: Animals; Ascorbic Acid; Cells, Cultured; Endothelium; Hydrogen Peroxide; Iron Chelating Agents; Liver; Nitric Oxide; Nitrogen Oxides; Oxygen; Rats; Spermine; Tyrosine | 1998 |
Lipopolysaccharide-induced increase in plasma nitrotyrosine concentrations in rats.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Lipopolysaccharides; Male; Nitrates; Nitrites; Rats; Rats, Wistar; Tyrosine | 1997 |
Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Enzyme Inhibitors; Fetus; Free Radical Scavengers; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidants; Rats; Spinal Cord; Superoxides; Tyrosine | 1998 |
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
Topics: Adenoma; Blotting, Western; Carcinoma; Colon; Colonic Neoplasms; Disease Progression; DNA Primers; DNA, Neoplasm; Endothelial Growth Factors; Endothelium, Vascular; Humans; Immunohistochemistry; Lymphokines; Neoplasm Proteins; Neovascularization, Pathologic; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Polymerase Chain Reaction; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cell Nucleus; DNA Damage; DNA Nucleotidylexotransferase; Humans; Middle Aged; Neurofibrillary Tangles; Neurons; Reference Values; Tyrosine; Visual Cortex | 1997 |
In vivo formation of electron paramagnetic resonance-detectable nitric oxide and of nitrotyrosine is not impaired during murine leishmaniasis.
Topics: Animals; Electron Spin Resonance Spectroscopy; Female; Immunohistochemistry; Leishmaniasis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Tyrosine | 1998 |
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cells, Cultured; Creatine Kinase; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Tyrosine | 1997 |
Transient changes in the presence of nitric oxide synthases and nitrotyrosine immunoreactivity after focal cortical lesions.
Topics: Animals; Cerebral Infarction; Immunohistochemistry; Ischemic Attack, Transient; Isoenzymes; Lectins; Male; NADPH Dehydrogenase; Nitric Oxide Synthase; Rats; Rats, Wistar; Somatosensory Cortex; Thrombosis; Tyrosine | 1998 |
Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the peri-infarct region.
Topics: Animals; Chromatography, High Pressure Liquid; Ischemic Attack, Transient; Male; Nitrates; Rats; Rats, Sprague-Dawley; Reperfusion; Tyrosine | 1998 |
3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method.
Topics: Adult; Binding, Competitive; Blood Proteins; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Humans; Lipoproteins, LDL; Serum Albumin; Tyrosine | 1998 |
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats.
Topics: Aging; Animals; Antioxidants; Biomarkers; Copper; Female; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Nitrates; Nitrogen; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Serum Albumin, Bovine; Tyrosine | 1998 |
Involvement of nitric oxide in survival of random pattern skin flap.
Topics: Animals; Arginine; Blotting, Western; Endothelium, Vascular; Enzyme Inhibitors; Free Radicals; Graft Survival; Injections, Intraperitoneal; Ischemia; Laser-Doppler Flowmetry; Male; Microcirculation; Necrosis; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidation-Reduction; Rats; Rats, Wistar; Regional Blood Flow; Skin; Skin Transplantation; Tyrosine | 1998 |
Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs.
Topics: Animals; Dogs; Enzyme Inhibitors; Guanidines; Hemodynamics; Isothiuronium; Lipopolysaccharides; Lung; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Gas Exchange; Respiratory Distress Syndrome; Tyrosine | 1998 |
Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis.
Topics: Acute Disease; Adolescent; Adult; Analysis of Variance; Antibodies, Monoclonal; Blotting, Western; Colitis, Ulcerative; Colon; Enzyme Induction; Female; Humans; Immunohistochemistry; Intestinal Mucosa; Isoenzymes; Male; Middle Aged; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 1998 |
Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation?
Topics: Antioxidants; Caffeic Acids; Chlorogenic Acid; Chromans; Chromatography, High Pressure Liquid; Coumaric Acids; Free Radical Scavengers; Free Radicals; Nitrates; Spectrophotometry; Tyrosine | 1998 |
Plasma 3-nitrotyrosine is elevated in premature infants who develop bronchopulmonary dysplasia.
Topics: Bronchopulmonary Dysplasia; Female; Humans; Infant, Newborn; Infant, Premature; Male; Nitrates; Oxidants; Oxidative Stress; Pilot Projects; Retrospective Studies; Tyrosine | 1998 |
Artefacts in HPLC detection of 3-nitrotyrosine in human brain tissue.
Topics: Artifacts; Brain; Cadaver; Chromatography, High Pressure Liquid; Humans; Nerve Degeneration; Nervous System Diseases; Reference Values; Tyrosine | 1998 |
Enzymatic reduction of 3-nitrotyrosine generates superoxide.
Topics: Chromatography, High Pressure Liquid; Cytochrome c Group; Electron Spin Resonance Spectroscopy; Enkephalin, Leucine; Kinetics; Mass Spectrometry; Oxidation-Reduction; Peptide Fragments; Superoxides; Trypsin; Tyrosine | 1998 |
Protein nitration in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Humans; Immunohistochemistry; Lewy Bodies; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Substantia Nigra; Tyrosine | 1998 |
Nitric oxide production and perivascular tyrosine nitration following focal ischemia in neonatal rat.
Topics: Animals; Animals, Newborn; Brain; Cell Death; Female; Immunoenzyme Techniques; Ischemic Attack, Transient; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 1998 |
Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Mass Spectrometry; Mitochondria; Molecular Sequence Data; Nitrates; Peptide Fragments; Recombinant Proteins; Sequence Analysis; Serine Endopeptidases; Superoxide Dismutase; Tyrosine | 1998 |
Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosine.
Topics: Amino Acids; Animals; Carbon Isotopes; Cattle; Chromatography, Ion Exchange; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Myocardium; Oxidation-Reduction; Proteins; Rats; Reproducibility of Results; Sensitivity and Specificity; Serum Albumin, Bovine; Tyrosine | 1998 |
Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Biotransformation; Liver; Male; Mice; Nitrates; Nitric Oxide; Proteins; Tyrosine | 1998 |
Inducible nitric oxide synthase expression in smooth muscle cells and macrophages of human transplant coronary artery disease.
Topics: Adult; Child; Child, Preschool; Coronary Artery Disease; Coronary Disease; Coronary Vessels; Endothelium, Vascular; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Heart Transplantation; Humans; In Situ Hybridization; Macrophages; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Tyrosine | 1998 |
Increased nitric oxide in nasal lavage fluid and nitrotyrosine formation in nasal mucosa--indices for severe perennial nasal allergy.
Topics: Adult; Cyclic GMP; Hemoglobins; Humans; Nasal Lavage Fluid; Nasal Mucosa; Nitrates; Nitric Oxide; Nitrites; Rhinitis, Allergic, Perennial; Tyrosine | 1998 |
Inducible nitric oxide synthase and nitrotyrosine are found in monocytes/macrophages and/or astrocytes in acute, but not in chronic, multiple sclerosis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Antibodies, Monoclonal; Astrocytes; Brain; Chronic Disease; Diffuse Cerebral Sclerosis of Schilder; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Macrophages; Male; Middle Aged; Monocytes; Multiple Sclerosis; Myelin Sheath; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 1998 |
Evidence for in vivo peroxynitrite production in human chronic hepatitis.
Topics: Adult; Antibodies; Antibody Specificity; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunohistochemistry; Liver Cirrhosis; Male; Middle Aged; Nitrates; Tyrosine | 1998 |
Nitration of the low molecular weight neurofilament is equivalent in sporadic amyotrophic lateral sclerosis and control cervical spinal cord.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Blotting, Western; Humans; Isoelectric Focusing; Middle Aged; Neurofilament Proteins; Nitrates; Precipitin Tests; Spinal Cord; Tyrosine | 1998 |
Neopterin derivatives modulate the nitration of tyrosine by peroxynitrite.
Topics: Hydrogen-Ion Concentration; Neopterin; Nitrates; Nitro Compounds; Pteridines; Pterins; Spectrophotometry; Tyrosine | 1998 |
Peroxynitrite formation within the central nervous system in active multiple sclerosis.
Topics: Central Nervous System; Humans; Immunohistochemistry; Inflammation; Multiple Sclerosis; Nervous System Diseases; Nitrates; Nitrites; Recurrence; Tyrosine | 1998 |
Inhaled nitric oxide primes lung macrophages to produce reactive oxygen and nitrogen intermediates.
Topics: Administration, Inhalation; Animals; Antibodies; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Epithelial Cells; Interferon-gamma; Lipopolysaccharides; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen; Oxidants; Proteins; Pulmonary Alveoli; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilator Agents | 1998 |
Comparison of detection methods for liquid chromatographic determination of 3-nitro-L-tyrosine.
Topics: Animals; Chromatography, Liquid; Electrochemistry; Microdialysis; Oxidation-Reduction; Photolysis; Rats; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tyrosine | 1998 |
Role of peroxynitrite and poly (ADP-ribosyl) synthetase activation in cardiovascular derangement induced by zymosan in the rat.
Topics: Animals; Aortic Diseases; Benzamides; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraperitoneal; Male; Niacinamide; Nitrates; Oxidants; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Shock, Cardiogenic; Tyrosine; Zymosan | 1998 |
An activity in rat tissues that modifies nitrotyrosine-containing proteins.
Topics: Animals; Cattle; In Vitro Techniques; Lipopolysaccharides; Male; Protein Processing, Post-Translational; Proteins; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Spleen; Substrate Specificity; Tyrosine | 1998 |
Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP2B1; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gas Chromatography-Mass Spectrometry; Microsomes, Liver; NADP; Nitrates; Nitric Oxide; Rats; Rats, Long-Evans; tert-Butylhydroperoxide; Tyrosine | 1998 |
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Female; Free Radical Scavengers; Humans; Male; Nitrates; Nitrites; Oxidation-Reduction; Tyrosine; Uric Acid | 1998 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Apoptosis; Brain Chemistry; Caspase 2; Caspase Inhibitors; Caspases; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Female; Free Radicals; Gene Expression; Homovanillic Acid; Injections, Intraperitoneal; Male; Mazindol; Mice; Mice, Transgenic; MPTP Poisoning; Neurons; Neurotoxins; Oxidative Stress; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Radioligand Assay; Tritium; Tyrosine | 1998 |
Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation.
Topics: Animals; Apoptosis; Benzamides; Caspase 1; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cysteine Endopeptidases; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; Mice; Nitrates; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thymus Gland; Tyrosine | 1998 |
Optimization of post-column photolysis and electrochemical detection for the liquid chromatographic determination of 3-nitro-L-tyrosine.
Topics: Animals; Chromatography, Liquid; Electrochemistry; Light; Photolysis; Rats; Spectrophotometry, Ultraviolet; Tyrosine | 1998 |
Increased nitrotyrosine in the diabetic placenta: evidence for oxidative stress.
Topics: Biomarkers; Chorionic Villi; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Placenta; Pregnancy; Pregnancy in Diabetics; Pregnancy Outcome; Reference Values; Superoxide Dismutase; Tyrosine | 1998 |
Induction of microglial reaction and expression of nitric oxide synthase I in the nucleus dorsalis and red nucleus following lower thoracic spinal cord hemisection.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Functional Laterality; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Male; Membrane Glycoproteins; Microglia; Nerve Degeneration; Neurons; Nitric Oxide Synthase; Rats; Rats, Wistar; Red Nucleus; Spinal Cord; Spinal Cord Injuries; Tegmentum Mesencephali; Tyrosine | 1998 |
Peroxynitrite is not a major mediator of endothelial cell injury by activated neutrophils in vitro.
Topics: Animals; Antibodies, Monoclonal; Cattle; CD18 Antigens; Cells, Cultured; Coculture Techniques; Deferoxamine; Dimethyl Sulfoxide; Endothelium, Vascular; Humans; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide Synthase; Nitrites; Ornithine; Penicillamine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model.
Topics: Animals; Anti-Bacterial Agents; Bleomycin; Disease Models, Animal; Hydroxyproline; Immunohistochemistry; Lung; Lung Diseases, Interstitial; Macrophages, Alveolar; Mice; Nitric Oxide; Superoxides; Tyrosine | 1998 |
Inductions of 3-L-nitrotyrosine in motor neurons after transient spinal cord ischemia in rabbits.
Topics: Animals; Chromatography, High Pressure Liquid; Immunohistochemistry; Ischemia; Motor Neurons; Rabbits; Reference Values; Spinal Cord; Tyrosine | 1998 |
Toxic effects of sulphite in combination with peroxynitrite on neuronal cells.
Topics: Animals; Cell Line; Cell Survival; DNA Fragmentation; Drug Combinations; Neurons; Nitrates; Oxidants; Rats; Sulfites; Tyrosine | 1998 |
Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Blood Proteins; Blotting, Western; Celiac Disease; Enzyme-Linked Immunosorbent Assay; Hemocyanins; Humans; Immunohistochemistry; Mice; Nitrates; Serum Albumin, Bovine; Tyrosine | 1998 |
Superoxide released from neutrophils causes a reduction in nitric oxide gas.
Topics: Animals; Cell Line; Cell Survival; Epithelial Cells; Gases; Humans; Hydrogen-Ion Concentration; Lung; Mice; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Superoxides; Tyrosine | 1998 |
Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys.
Topics: Anemia, Sickle Cell; Animals; Apoptosis; Blotting, Western; Immunohistochemistry; Kidney; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 1998 |
Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury.
Topics: Animals; Blood Vessels; Bronchi; Bronchoalveolar Lavage Fluid; Coloring Agents; Disease Models, Animal; Endotoxins; Epithelium; Escherichia coli; Female; Follow-Up Studies; Isoenzymes; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Macrophages, Alveolar; Male; Mice; Mice, Knockout; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Size; Pulmonary Alveoli; Respiratory Distress Syndrome; Tyrosine; Vasodilator Agents | 1998 |
Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase.
Topics: Animals; Cell Division; Cells, Cultured; DNA Damage; Enzyme Inhibitors; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroarginine; Oxidation-Reduction; Rhodamine 123; Rhodamines; Tyrosine | 1998 |
Nitric oxide synthase plays a signaling role in TCR-triggered apoptotic death.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Apoptosis; Dexamethasone; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Hybridomas; Indazoles; Interleukin-2; Jurkat Cells; Lectins, C-Type; Lymphocyte Activation; Membrane Glycoproteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tyrosine | 1998 |
Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Enzyme Inhibitors; Free Radical Scavengers; Guanidines; Immunohistochemistry; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tyrosine | 1998 |
Intra-coronary administration of L-arginine aggravates myocardial stunning through production of peroxynitrite in dogs.
Topics: Analysis of Variance; Animals; Arginine; Chromatography, High Pressure Liquid; Dogs; Enzyme Inhibitors; Female; Immunohistochemistry; Isomerism; Lipid Peroxidation; Male; Malondialdehyde; Microdialysis; Myocardial Contraction; Myocardial Stunning; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Random Allocation; Superoxide Dismutase; Tyrosine | 1998 |
Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Dose-Response Relationship, Drug; Edema; Foot; Free Radical Scavengers; Male; Melatonin; Nitrates; Oxidants; Plasma; Rats; Rats, Wistar; Tyrosine | 1998 |
Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state.
Topics: Animals; Gene Expression; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscles; Necrosis; Nitric Oxide; Oxidative Stress; Oxidoreductases; Reference Values; Tyrosine | 1998 |
Specific inhibition of iNOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury.
Topics: Animals; Antioxidants; Bacterial Translocation; Body Surface Area; Burns; Coloring Agents; Enzyme Inhibitors; Female; Intestinal Mucosa; Intestine, Small; Isothiuronium; Liver; Lymph Nodes; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Rats; Rats, Sprague-Dawley; Spleen; Superoxides; Tyrosine | 1998 |
An inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune myocarditis in Lewis rats.
Topics: Animals; Autoimmune Diseases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Myocarditis; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Tyrosine | 1998 |
Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions.
Topics: Adult; Blotting, Western; Granuloma; Histiocytic Necrotizing Lymphadenitis; Humans; Immunohistochemistry; Infections; Interferon-gamma; Interleukin-4; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Tissue Distribution; Tyrosine | 1999 |
A one-step method for protein estimation in biological samples: nitration of tyrosine in nitric acid.
Topics: Evaluation Studies as Topic; HL-60 Cells; Humans; Indicators and Reagents; K562 Cells; Nitric Acid; Proteins; Spectrophotometry, Ultraviolet; Tyrosine | 1999 |
Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.
Topics: Animals; Colitis; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Malondialdehyde; Mice; Neutrophils; Oxidative Stress; Permeability; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine; Up-Regulation | 1999 |
Correlation of serum measures of nitric oxide production with lupus disease activity.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear; Blood Sedimentation; Complement C3; Complement C4; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Predictive Value of Tests; Tyrosine | 1999 |
Role of nitric oxide in lipopolysaccharide-induced hepatic injury in D-galactosamine-sensitized mice as an experimental endotoxic shock model.
Topics: Animals; Disease Models, Animal; Female; Galactosamine; Heat-Shock Proteins; Lipopolysaccharides; Liver; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; RNA, Messenger; Shock, Septic; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistry; Inflammation; Interferon-gamma; Interleukin-10; Intestinal Mucosa; Intestines; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Shock, Septic; Spermine; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat.
Topics: Acetylcysteine; Animals; Cell Membrane Permeability; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Macrophages, Peritoneal; Male; NAD; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sepsis; Shock; Tyrosine; Zymosan | 1999 |
Peroxynitrite formation during rat hepatic allograft rejection.
Topics: Animals; Blood Transfusion; Enzyme Inhibitors; Graft Rejection; Graft Survival; Liver Transplantation; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Inbred ACI; Rats, Inbred Lew; RNA, Messenger; Tacrolimus; Tissue Donors; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine | 1999 |
Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat.
Topics: Animals; Aorta; Blood Platelets; Blood Vessels; Blotting, Western; Carbon Monoxide Poisoning; Carboxyhemoglobin; Cholesterol, Dietary; Endothelium, Vascular; Immunohistochemistry; Leukocytes; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 1999 |
Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisy.
Topics: Animals; Antioxidants; Benzofurans; Carrageenan; Cell Respiration; Energy Metabolism; Excipients; Immunohistochemistry; Lung; Macrophages, Alveolar; Malondialdehyde; Peroxidase; Pleurisy; Rats; Tyrosine; Vitamin E | 1999 |
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Creatine; Disease Models, Animal; Glycine; Humans; Mice; Mice, Transgenic; Motor Activity; Muscle, Skeletal; Neurons; Neuroprotective Agents; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine; Tyrosine 3-Monooxygenase | 1999 |
Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Fibroblast Growth Factors; Humans; Immunohistochemistry; Nitric Oxide Synthase; Pancreatic Neoplasms; Retrospective Studies; Tyrosine | 1999 |
Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death.
Topics: Apoptosis; CD3 Complex; Cell Division; Cells, Cultured; Dose-Response Relationship, Immunologic; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphocyte Activation; Metalloporphyrins; Monocytes; Nitrates; Nitric Oxide Synthase; Phosphorylation; Proteins; Superoxide Dismutase; T-Lymphocytes; Time Factors; Tyrosine | 1999 |
Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Count; Dopamine Agents; Enzyme Inhibitors; Immunohistochemistry; Indazoles; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Papio; Substantia Nigra; Tyrosine | 1999 |
Formation of 4-hydroxy-2-nonenal-modified proteins and 3-nitro-L-tyrosine in rat island skin flaps during and after ischemia.
Topics: Aldehydes; Animals; Blotting, Western; Free Radicals; Ischemia; Male; Proteins; Rats; Rats, Wistar; Reperfusion Injury; Skin; Specific Pathogen-Free Organisms; Surgical Flaps; Tyrosine | 1999 |
Detection of 3-nitrotyrosine in human platelets exposed to peroxynitrite by a new gas chromatography/mass spectrometry assay.
Topics: Blood Platelets; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Nitrates; Nitrogen Dioxide; Sensitivity and Specificity; Tyrosine | 1998 |
Nitrate reductase alters 3-nitrotyrosine accumulation and cell cycle progression in LPS + IFN-gamma-stimulated RAW 264.7 cells.
Topics: Animals; Cell Cycle; Cell Line; Enzyme Inhibitors; Flow Cytometry; Free Radicals; Hordeum; Interferon-gamma; Lipopolysaccharides; Mice; Nitrate Reductase; Nitrate Reductases; Nitrates; Nitrites; Transfection; Tyrosine | 1998 |
Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite.
Topics: Animals; Ethanol; Female; Free Radicals; Glycogen; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Nitrates; Oxidants; Oxidative Stress; Oxygen; Perfusion; Rats; Rats, Sprague-Dawley; Tyrosine | 1999 |
Effect of beta-carotene on the transformation of tyrosine by nitrogen dioxide and peroxynitrous acid.
Topics: Ascorbic Acid; beta Carotene; Dioxanes; Dose-Response Relationship, Drug; Free Radical Scavengers; Nitrogen Dioxide; Nitrous Acid; Peroxynitrous Acid; Time Factors; Tyrosine; Vitamin E | 1999 |
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Topics: Animals; Autoimmune Diseases; CD4 Antigens; Disease Susceptibility; HLA-DQ Antigens; Humans; Immunization; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myocarditis; Myocardium; Myosin Heavy Chains; Myosins; Peptide Fragments; Phenotype; Tyrosine | 1999 |
Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS Dementia Complex; Brain Chemistry; Female; HIV Infections; HIV-1; Humans; Immunohistochemistry; Interleukin-1; Interleukin-10; Macrophages; Male; Middle Aged; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Superoxide Dismutase; Superoxides; Tyrosine | 1999 |
Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease.
Topics: Adult; Colitis, Ulcerative; Crohn Disease; Epithelial Cells; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Male; Middle Aged; Nitric Oxide Synthase; Reactive Oxygen Species; Tyrosine | 1998 |
Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia.
Topics: Animals; Azides; Cell Survival; Cells, Cultured; Enzyme Activation; Glutamate Dehydrogenase; Inflammation; Ketoglutarate Dehydrogenase Complex; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Mitochondria; Nitrates; Nitric Oxide; Oxidative Stress; Oxidoreductases; Oxygen Consumption; Reactive Oxygen Species; Tyrosine | 1999 |
Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase.
Topics: Angiotensin II; Animals; Carbon Radioisotopes; Cattle; Coronary Vasospasm; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprostone; Epoprostenol; Immunohistochemistry; In Vitro Techniques; Intramolecular Oxidoreductases; Nitrates; Oxidants; Potassium Chloride; Prostaglandin Antagonists; Prostaglandin H2; Prostaglandins; Prostaglandins H; Proteins; Tyrosine; Vasoconstriction; Vasodilation | 1999 |
Activation pattern of mitogen-activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epithelium; Glutathione Peroxidase; Hydrogen Peroxide; Liver; Nitrates; Nitric Oxide; Phosphorylation; Rats; Sodium Selenite; Time Factors; Tyrosine | 1999 |
Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sigmoid Neoplasms; Tyrosine | 1999 |
Novel free radical spin traps protect against malonate and MPTP neurotoxicity.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Free Radicals; Isoquinolines; Male; Malonates; Mice; MPTP Poisoning; Neuroprotective Agents; Nitrogen Oxides; Spin Labels; Tyrosine | 1999 |
Loss of 3-nitrotyrosine on exposure to hypochlorous acid: implications for the use of 3-nitrotyrosine as a bio-marker in vivo.
Topics: Biomarkers; Hypochlorous Acid; Reactive Oxygen Species; Tyrosine | 1999 |
In vivo disposition of 3-nitro-L-tyrosine in rats: implications on tracking systemic peroxynitrite exposure.
Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Half-Life; Infusions, Intravenous; Male; Nitrates; Oxidants; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tyrosine | 1999 |
Role of inducible nitric oxide synthase in the cerebral vasospasm after subarachnoid hemorrhage in rats.
Topics: Animals; Antibodies; Cerebral Arteries; Cerebrovascular Circulation; DNA Probes; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanidines; Immunohistochemistry; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Subarachnoid Hemorrhage; Tyrosine; Vasoconstriction | 1999 |
Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries.
Topics: Animals; Arteriosclerosis; Cattle; Coronary Vessels; Cytochrome P-450 Enzyme System; Immunohistochemistry; Intramolecular Oxidoreductases; Nitrates; Prostaglandins; Tyrosine; Vasodilation | 1999 |
Nitrotyrosine formation after activation of murine macrophages with mycobacteria and mycobacterial lipoarabinomannan.
Topics: Animals; Female; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; omega-N-Methylarginine; Rabbits; Reactive Oxygen Species; Tyrosine | 1999 |
Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury.
Topics: Amino Acid Sequence; Binding Sites; Cell Membrane Permeability; Dyneins; Humans; Microtubules; Nitric Oxide; Peptide Synthases; Protein Processing, Post-Translational; Tubulin; Tumor Cells, Cultured; Tyrosine | 1999 |
High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells. A potential mechanism of injury after marrow transplantation.
Topics: Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Disease Models, Animal; Female; L-Lactate Dehydrogenase; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; T-Lymphocytes; Time Factors; Tyrosine | 1999 |
Expression of inducible nitric oxide synthase in human coronary atherosclerotic plaque.
Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Coronary Artery Disease; Coronary Vessels; Female; Humans; Immunohistochemistry; Macrophages; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Temporal distribution of neuronal and inducible nitric oxide synthase and nitrotyrosine during colitis in rats.
Topics: Animals; Colitis; Immunohistochemistry; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine | 1999 |
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
Topics: Aging; Amino Acid Sequence; Animals; Biological Transport; Calcium; Calcium-Transporting ATPases; Cysteine; Endopeptidases; Isoenzymes; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Nitrates; Nitric Oxide; Oxygen; Peptide Fragments; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sulfhydryl Compounds; Tyrosine | 1999 |
Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Guanidines; Half-Life; Hydrolysis; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 1999 |
Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hypochlorous Acid; Indicators and Reagents; Molsidomine; Nitrates; Nitrites; Nitrogen Oxides; Serum Albumin, Bovine; Sodium Nitrite; Spectrophotometry, Ultraviolet; Spermine; Tyrosine | 1999 |
Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cell Survival; Chromosomes, Human, Pair 14; Humans; Intracellular Membranes; Lipid Peroxidation; Membrane Lipids; Membrane Potentials; Membrane Proteins; Mitochondria; Mutagenesis, Site-Directed; Neurons; PC12 Cells; Peptide Fragments; Presenilin-1; Rats; Reactive Oxygen Species; Recombinant Proteins; Superoxide Dismutase; Superoxides; Tyrosine | 1999 |
Effects of hard metal on nitric oxide pathways and airway reactivity to methacholine in rat lungs.
Topics: Air Pollutants; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Chromium; Cobalt; Iron; Lung; Male; Metals; Methacholine Chloride; Nitric Oxide; Nitric Oxide Synthase; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Suspensions; Tungsten; Tyrosine | 1999 |
Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine.
Topics: Adenoma, Bile Duct; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Immunohistochemistry; Liver; Liver Neoplasms; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Tyrosine | 1999 |
Direct energy transfer to study the 3D structure of non-native proteins: AGH complex in molten globule state of apomyoglobin.
Topics: Animals; Apoproteins; Energy Transfer; Horses; Models, Molecular; Myoglobin; Protein Conformation; Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectrophotometry; Tetranitromethane; Tryptophan; Tyrosine | 1999 |
Enhanced expression of inducible nitric oxide synthase and nitrotyrosine in gastric mucosa of gastric cancer patients.
Topics: Adult; Aged; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stomach Neoplasms; Tyrosine | 1999 |
Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation.
Topics: Carbon Dioxide; Escherichia coli; Glutamate-Ammonia Ligase; Glycine max; Hydrogen-Ion Concentration; Kinetics; Lipid Peroxidation; Lipoxygenase; Methionine; Models, Chemical; Nitrates; Oxidants; Oxidation-Reduction; Serum Albumin, Bovine; Tyrosine | 1999 |
The contribution of inducible nitric oxide and cytomegalovirus to the stability of complex carotid plaque.
Topics: Aged; Carotid Arteries; Carotid Stenosis; Cytomegalovirus Infections; Female; Humans; Immunohistochemistry; In Situ Hybridization; Intracranial Arteriosclerosis; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Recurrence; Risk Factors; Tyrosine | 1999 |
The protective role of endogenous glutathione in carrageenan-induced pleurisy in the rat.
Topics: Animals; Carrageenan; Cells, Cultured; Disease Models, Animal; Free Radical Scavengers; Glutathione; Macrophages; Nitrates; Nitric Oxide; Oxidants; Pleurisy; Protective Agents; Rats; Tyrosine | 1999 |
7-Nitroindazole attenuates nitrotyrosine formation in the early phase of cerebral ischemia-reperfusion in mice.
Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Indazoles; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Reperfusion Injury; Tyrosine | 1999 |
Role of interleukin-6 in a non-septic shock model induced by zymosan.
Topics: Animals; Antibodies, Monoclonal; Ascites; Ascitic Fluid; DNA Damage; Energy Metabolism; Injections, Intraperitoneal; Interleukin-6; Intestine, Small; Leukocyte Count; Lipid Peroxidation; Liver; Lung; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Multiple Organ Failure; NAD; Neutrophils; Nitrates; Nitrites; Oxidative Phosphorylation; Peritonitis; Peroxidase; Shock; Tyrosine; Zymosan | 1999 |
Tyrosine nitration in blood vessels occurs with increasing nitric oxide concentration.
Topics: Animals; Aorta, Thoracic; Cattle; In Vitro Techniques; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Rabbits; Superoxides; Tyrosine | 1999 |
Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Tyrosine | 1999 |
p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite.
Topics: Crk-Associated Substrate Protein; Humans; Molsidomine; Neuroblastoma; Nitrates; Nitric Oxide Donors; Oxidants; Phosphoproteins; Phosphorylation; Proteins; Retinoblastoma-Like Protein p130; Tumor Cells, Cultured; Tyrosine | 1999 |
Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage.
Topics: Animals; Brain; Cerebral Infarction; Citrulline; Corpus Striatum; Enzyme Activation; Functional Laterality; Immunohistochemistry; Injections, Intraperitoneal; Ischemic Attack, Transient; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Microinjections; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidants; Tyrosine | 1999 |
Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry.
Topics: Animals; Immunohistochemistry; Kidney; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Tyrosine | 1999 |
Denitration of peroxynitrite-treated proteins by "protein nitratases" from dog prostate.
Topics: Animals; beta-Fructofuranosidase; Blotting, Western; Dithiothreitol; Dogs; Enzyme Activation; Glutathione Transferase; Glycoside Hydrolases; Histones; Male; Nitrates; Oxidoreductases; Polylysine; Prostate; Serum Albumin; Tissue Extracts; Tyrosine | 1999 |
Hyperoxic lung injury increases HOCl-modified lung proteins and NA,K-adenosine triphosphatase nitrotyrosine content.
Topics: Animals; Lung; Oxygen; Rats; Respiratory Distress Syndrome; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1999 |
Peroxynitrite induces tryosine nitration and modulates tyrosine phosphorylation of synaptic proteins.
Topics: Animals; Brain; Brain Chemistry; Cattle; Dose-Response Relationship, Drug; Nitrates; Nitric Oxide; Oxidants; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; Synapses; Synaptophysin; Synaptosomes; Tyrosine | 1999 |
Inhaled nitric oxide reduces tyrosine nitration after lipopolysaccharide instillation into lungs of rats.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Instillation, Drug; Leukocyte Count; Lipopolysaccharides; Lung; Male; Nitric Oxide; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Tyrosine | 1999 |
Effects of reactive oxygen and nitrogen metabolites on RANTES- and IL-5-induced eosinophil chemotactic activity in vitro.
Topics: Chemokine CCL5; Chemotaxis; Deferoxamine; Dithiothreitol; Dose-Response Relationship, Drug; Eosinophils; Humans; Hydrazines; Interleukin-5; Leukotriene B4; Molsidomine; Nitrates; Nitric Oxide; Nitrogen; Pteridines; Reactive Oxygen Species; Superoxides; Tyrosine; Xanthine | 1999 |
Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Neurotoxins; Nitrates; Oxidants; Porphyrins; Reference Values; Tyrosine | 1999 |
Apocynin improves diaphragmatic function after endotoxin administration.
Topics: Acetophenones; Aldehydes; Animals; Antioxidants; Diaphragm; Endotoxins; Histocytochemistry; Immunoblotting; Kinetics; Lipid Peroxidation; Male; Muscle Contraction; Neutrophils; Rats; Rats, Sprague-Dawley; Tyrosine | 1999 |
EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology.
Topics: Animals; Catalase; Electrophoresis, Polyacrylamide Gel; Kainic Acid; Molecular Mimicry; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spectrin; Superoxide Dismutase; Tyrosine | 1999 |
Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders.
Topics: Animals; Eosinophil Peroxidase; Eosinophils; Inflammation; Kinetics; Nitric Oxide; Nitrites; Oxidative Stress; Peroxidases; Tyrosine | 1999 |
Protective effects of poly (ADP-ribose) synthase inhibitors in zymosan-activated plasma induced paw edema.
Topics: Animals; Benzamides; Complement Activation; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Free Radicals; Immunohistochemistry; Inflammation; Male; Niacinamide; Nitrates; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine; Zymosan | 1999 |
Effects of exogenous nitric oxide and hyperoxia on lung fibroblast viability and DNA fragmentation.
Topics: Antioxidants; Catalase; Cell Survival; Cells, Cultured; DNA Fragmentation; Fibroblasts; Humans; Hyperoxia; In Situ Nick-End Labeling; Lung; Nitrates; Nitric Oxide; Oxygen; Superoxides; Tyrosine | 1999 |
Formation and loss of nitrated proteins in peroxynitrite-treated rat skin in vivo.
Topics: Animals; Kinetics; Male; Nitrates; Oxidants; Proteins; Rats; Rats, Wistar; Serum Albumin, Bovine; Skin; Time Factors; Tyrosine | 1999 |
Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide.
Topics: Adult; Aged; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cell Count; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Neutrophil Activation; Nitric Oxide; Respiratory Distress Syndrome; Tyrosine | 1999 |
Localization of nitric oxide-related substances in the quail ovary during folliculogenesis.
Topics: Animals; Citrulline; Coturnix; Cyclic GMP; Female; Isoenzymes; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Ovarian Follicle; Ovary; Tyrosine | 1999 |
Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis.
Topics: Animals; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Free Radical Scavengers; Inflammation; Intracranial Pressure; Leukocytes; Male; Meningitis, Pneumococcal; Nitrates; Oxidants; Rats; Rats, Wistar; Subarachnoid Space; Tyrosine; Uric Acid | 1999 |
Effects of reactive oxygen and nitrogen metabolites on MCP-1-induced monocyte chemotactic activity in vitro.
Topics: Blood Physiological Phenomena; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Leukotriene B4; Monocytes; Nitrates; Nitrogen; Oxidants; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine | 1999 |
Inducible nitric oxide synthase in the lung and exhaled nitric oxide after hyperoxia.
Topics: Animals; Blotting, Western; Hyperoxia; Immunohistochemistry; Lipopolysaccharides; Luminescent Measurements; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Respiration; Shock, Septic; Time Factors; Tyrosine | 1999 |
Vascular peroxynitrite formation during organic nitrate tolerance.
Topics: Animals; Aorta, Thoracic; Blood Proteins; Drug Tolerance; Immunohistochemistry; Male; Nitrates; Nitroglycerin; Rats; Rats, Sprague-Dawley; Tyrosine; Vasodilator Agents | 1999 |
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
Topics: Animals; Cartilage, Articular; Culture Techniques; Cyclooxygenase 2; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Immunohistochemistry; Interleukin-1; Isoenzymes; Lysine; Metalloendopeptidases; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sensitivity and Specificity; Statistics, Nonparametric; Synovial Membrane; Tyrosine | 1999 |
IL-6 knock-out mice exhibit resistance to splanchnic artery occlusion shock.
Topics: Animals; Antibodies, Monoclonal; Arterial Occlusive Diseases; Celiac Artery; Constriction; Cytokines; Ileum; Immunity, Innate; Intercellular Adhesion Molecule-1; Interleukin-6; Ischemia; Leukocyte Count; Lipid Peroxidation; Malondialdehyde; Mesenteric Artery, Superior; Mice; Mice, Knockout; Neutrophils; Nitrates; Nitric Oxide; P-Selectin; Peroxidase; Reperfusion Injury; Shock; Splanchnic Circulation; Tyrosine | 1999 |
Monitoring nitrotyrosinylation of a synthetic peptide by capillary zone electrophoresis.
Topics: Electrophoresis, Capillary; Peptides; Tetranitromethane; Time Factors; Tyrosine | 1999 |
Increased nitric oxide inactivation by reactive oxygen species in lead-induced hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Blotting, Western; Brain Chemistry; Hypertension, Renal; Kidney; Lead; Lead Poisoning; Liver; Male; Myocardium; Nitric Oxide; Nitrogen Dioxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine; Vitamin E | 1999 |
Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis.
Topics: Acute Disease; Analysis of Variance; Animals; Aquaporin 1; Aquaporins; Capillary Permeability; Disease Models, Animal; Endothelial Growth Factors; Immunoassay; Immunohistochemistry; Isoenzymes; Lymphokines; Male; Nitric Oxide Synthase; Peritoneal Dialysis; Peritoneum; Peritonitis; Protein Isoforms; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination.
Topics: Adolescent; Adult; Aged; Biomarkers; Bronchoalveolar Lavage Fluid; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyl Radical; Hydroxylation; Hypochlorous Acid; Linear Models; Male; Middle Aged; Neutrophil Activation; Neutrophils; Nitrates; Oxidants; Oxidative Stress; Proteins; Respiration, Artificial; Respiratory Distress Syndrome; Statistics, Nonparametric; Tyrosine | 1999 |
Prostacyclin synthase is localized in rat, bovine and human neuronal brain cells.
Topics: Aged; Amino Acid Sequence; Animals; Animals, Newborn; Antibodies; Astrocytes; Blotting, Western; Cattle; Cells, Cultured; Cerebral Cortex; Cytochrome P-450 Enzyme System; Fluorescent Antibody Technique; Humans; Intramolecular Oxidoreductases; Middle Aged; Molecular Sequence Data; Purkinje Cells; Rats; Rats, Wistar; Tyrosine | 1999 |
Inhibitory mechanism of sinapinic acid against peroxynitrite-mediated tyrosine nitration of protein in vitro.
Topics: Chromatography, High Pressure Liquid; Coumaric Acids; Dimerization; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitrates; Oxidation-Reduction; Proteins; Tyrosine | 1999 |
A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock.
Topics: Animals; Cell Membrane Permeability; Cyclic N-Oxides; Free Radical Scavengers; Intestinal Mucosa; Intestines; Kidney; Liver; Lung; Male; Multiple Organ Failure; Rats; Rats, Wistar; Reactive Oxygen Species; Resuscitation; Shock, Hemorrhagic; Spin Labels; Tyrosine | 1999 |
Nitration of internal tyrosine of cytochrome c probed by resonance Raman scattering.
Topics: Animals; Cytochrome c Group; Heme; Horses; Hydrogen-Ion Concentration; Spectrum Analysis, Raman; Tyrosine | 1999 |
Beneficial effects of inducible nitric oxide synthase inhibitor on reperfusion injury in the pig liver.
Topics: Animals; Arteries; Aspartate Aminotransferases; Blood Pressure; Female; Fluorescent Antibody Technique; Liver; Microscopy, Confocal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reperfusion Injury; Survival Rate; Swine; Tyrosine | 1999 |
Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter pylori gastric ulcer.
Topics: Fluorescent Antibody Technique; Gastric Mucosa; Gastritis; Helicobacter pylori; Humans; Macrophages; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptic Ulcer; Tyrosine | 1999 |
Effects of reactive oxygen species on brain synaptic plasma membrane Ca(2+)-ATPase.
Topics: Age Factors; Amidines; Animals; Azo Compounds; Brain; Calcium; Calcium-Transporting ATPases; Hydrogen Peroxide; Kinetics; Male; Nitrates; Oxidative Stress; Phenylhydrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Synaptic Membranes; Tyrosine; Urea; Valerates | 1999 |
Endothelial cell nitric oxide production in acute chest syndrome.
Topics: Animals; Blood Physiological Phenomena; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Hemoglobin SC Disease; Humans; Lung Diseases; Mercaptoethanol; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroso Compounds; RNA, Messenger; S-Nitrosothiols; Sulfhydryl Compounds; Tyrosine | 1999 |
Nitrotyrosine formation in the airways and lung parenchyma of patients with asthma.
Topics: Adolescent; Adult; Asthma; Bronchi; Female; Fluorescent Antibody Technique; Free Radicals; Humans; Lung; Male; Middle Aged; Models, Immunological; Nitric Oxide; Nitrogen Compounds; Status Asthmaticus; Tyrosine | 1999 |
Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis.
Topics: Animals; Apoptosis; Cells, Cultured; Menisci, Tibial; Nitric Oxide; Osteoarthritis; Rabbits; Tyrosine | 1999 |
Role of IL-6 in the pleurisy and lung injury caused by carrageenan.
Topics: Animals; Carrageenan; Cells, Cultured; Cytokines; Dinoprostone; DNA Damage; Enzyme Induction; Interleukin-6; Leukotriene B4; Lung; Macrophages; Male; Malondialdehyde; Mice; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Pleura; Pleurisy; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Prostaglandins F; Tyrosine | 1999 |
Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-alpha.
Topics: Apoptosis; Astrocytes; Cell Count; Cell Culture Techniques; Fetus; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-1; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Modification of proteins and polynucleotides by peroxynitrite.
Topics: Animals; Nitrates; Nitric Oxide; Oxidants; Proteins; Rabbits; Tyrosine | 1999 |
Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Dogs; Echocardiography; Female; Interleukin-1; Male; Myocardium; Nitrates; Random Allocation; Stroke Volume; Superoxides; Thiazoles; Tyrosine; Ventricular Dysfunction, Left | 1999 |
The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat.
Topics: Animals; Carrageenan; Cells, Cultured; Energy Metabolism; Lipid Peroxidation; Macrophages; Melatonin; Nitrates; Nitric Oxide; Peroxidase; Pleurisy; Rats; Tyrosine | 1999 |
Factors determining the selectivity of protein tyrosine nitration.
Topics: Amino Acid Sequence; Models, Molecular; Molecular Sequence Data; Muramidase; Nitrates; Nitric Oxide; Phospholipases A; Protein Processing, Post-Translational; Protein Structure, Secondary; Ribonuclease, Pancreatic; Sequence Analysis, Protein; Superoxides; Tyrosine | 1999 |
Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin.
Topics: Endothelium, Vascular; Humans; Immunoenzyme Techniques; Microcirculation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Scleroderma, Systemic; Severity of Illness Index; Skin; Tyrosine | 1999 |
Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against laryngeal injury in rats.
Topics: Animals; Benzamides; Enzyme Inhibitors; Immunohistochemistry; Intubation, Intratracheal; Laryngeal Mucosa; Larynx; Male; Neutrophils; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Tyrosine; Wounds and Injuries | 1999 |
Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Heme; Sulfhydryl Compounds; Tyrosine | 1999 |
Immunohistochemical nitrotyrosine distribution in neonatal rat cerebrocortical slices during and after hypoxia.
Topics: Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hypoxia-Ischemia, Brain; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superoxides; Tyrosine | 1999 |
Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in non-septic shock induced by zymosan.
Topics: Animals; Antioxidants; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Kidney; Lipid Peroxidation; Liver; Lung; Male; Malondialdehyde; Melatonin; Nitrates; Rats; Rats, Sprague-Dawley; Shock; Tyrosine; Zymosan | 1999 |
Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acids; Animals; Brain; Chelating Agents; Dopamine Agents; Free Radicals; Gas Chromatography-Mass Spectrometry; Male; Mice; Mice, Inbred C57BL; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Pentetic Acid; Tissue Distribution; Tyrosine | 1999 |
Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in zymosan-induced shock.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Immunohistochemistry; L-Lactate Dehydrogenase; Lung; Male; Malondialdehyde; Metalloporphyrins; NAD; Nitrates; Peroxidase; Rats; Rats, Sprague-Dawley; Shock; Superoxide Dismutase; Tyrosine; Zymosan | 1999 |
Protein carbonyl formation and tyrosine nitration as markers of oxidative damage during ischaemia-reperfusion injury to rat sciatic nerve.
Topics: Animals; Biomarkers; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Ischemia; Male; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sciatic Nerve; Sensitivity and Specificity; Time Factors; Tyrosine | 1999 |
Increased protein nitrosylation in head and neck squamous cell carcinogenesis.
Topics: Adult; Analysis of Variance; Carcinoma, Squamous Cell; Culture Techniques; Disease Progression; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Proteins; Nitric Oxide; Reference Values; Staining and Labeling; Statistics, Nonparametric; Tyrosine | 2000 |
The in vitro manipulation of carbohydrate metabolism: a new strategy for deciphering the cellular defence mechanisms against nitric oxide attack.
Topics: Adenosine Triphosphate; Carbohydrate Metabolism; Cell Survival; Culture Media; Deoxyglucose; Epithelial Cells; Galactose; Glucose; Glutathione; HT29 Cells; Humans; Lactic Acid; Nitric Oxide; Nitroso Compounds; Oligomycins; Pyruvic Acid; S-Nitrosoglutathione; Tyrosine | 1999 |
NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge.
Topics: Animals; Bacteremia; Enterobacteriaceae; Enterocytes; Free Radical Scavengers; Infusion Pumps, Implantable; Intestinal Absorption; Intestines; Lipopolysaccharides; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tyrosine | 1999 |
Gas chromatographic-tandem mass spectrometric quantification of free 3-nitrotyrosine in human plasma at the basal state.
Topics: Adult; Carbon Radioisotopes; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Nitric Oxide; Oxidative Stress; Reference Standards; Reference Values; Reproducibility of Results; Tyrosine | 1999 |
Quantitative analysis of cardiac 3-L-nitrotyrosine during acute allograft rejection in an experimental heart transplantation.
Topics: Acute Disease; Animals; Chromatography, High Pressure Liquid; Graft Rejection; Heart Transplantation; Male; Myocardium; Rats; Rats, Inbred F344; Rats, Inbred Lew; Time Factors; Transplantation, Homologous; Tyrosine | 1999 |
Ceramide prevents motoneuronal cell death through inhibition of oxidative signal.
Topics: Aldehydes; Animals; Antioxidants; Buthionine Sulfoximine; Cell Death; Cell Survival; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Glial Cell Line-Derived Neurotrophic Factor; Glutathione; Immunohistochemistry; Lipid Peroxidation; Motor Neurons; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Tyrosine | 1999 |
Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia.
Topics: Adult; Catalase; Chorionic Villi; Female; Humans; Oxidative Stress; Pre-Eclampsia; Pregnancy; Reference Values; Superoxide Dismutase; Trophoblasts; Tyrosine; Xanthine Dehydrogenase; Xanthine Oxidase | 2000 |
Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Chemotaxis, Leukocyte; Endothelium, Vascular; Free Radical Scavengers; Ileal Diseases; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Melatonin; Mesenteric Artery, Superior; Neutrophils; Oxidative Stress; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splanchnic Circulation; Tyrosine | 2000 |
Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Mutation; Neuroglia; Neurons; Spinal Cord; Superoxide Dismutase; Tyrosine | 2000 |
Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catechols; Convulsants; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Female; Free Radicals; Glutathione; Glutathione Peroxidase; Heterozygote; Homovanillic Acid; Homozygote; Huntington Disease; Male; Malonates; Mice; Mice, Inbred Strains; Mice, Knockout; MPTP Poisoning; Nitro Compounds; Oxidative Stress; Parkinson Disease, Secondary; Propionates; Tyrosine | 2000 |
Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis.
Topics: Administration, Intranasal; Adult; Chemokine CCL11; Chemokines, CC; Cytokines; Dose-Response Relationship, Drug; Eosinophils; Female; Humans; Male; Nasal Mucosa; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rhinitis, Allergic, Perennial; Therapeutic Irrigation; Tyrosine | 2000 |
Denitration of peroxynitrite-treated proteins by 'protein nitratases' from rat brain and heart.
Topics: Animals; beta-Fructofuranosidase; Blotting, Western; Brain; Brain Chemistry; Calcium; Dialysis; Enzymes; Flavin-Adenine Dinucleotide; Glutathione; Glutathione Transferase; Glycoside Hydrolases; Myocardium; NAD; NADP; Nitrates; Proteins; Rats; Serum Albumin, Bovine; Tissue Extracts; Tyrosine | 1999 |
Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells.
Topics: Binding Sites; Breast Neoplasms; Female; Glutathione; Humans; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Protein Processing, Post-Translational; S-Nitrosoglutathione; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrosine | 2000 |
Oxidative stress precedes circulatory failure induced by 35-GHz microwave heating.
Topics: Animals; Biomarkers; Blood Pressure; Body Temperature; Heart Rate; Hemodynamics; Hot Temperature; Intestines; Kidney Tubules, Distal; Liver; Male; Microwaves; Oxidative Stress; Rats; Rats, Sprague-Dawley; Shock; Tyrosine | 2000 |
Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscle.
Topics: Animals; Diastole; Immunoenzyme Techniques; Male; Myocardial Contraction; Nitrates; Oxidants; Papillary Muscles; Rats; Systole; Tyrosine | 1999 |
Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts.
Topics: Adult; Artifacts; Blood Proteins; Gas Chromatography-Mass Spectrometry; Humans; Male; Nitrates; Tyrosine | 2000 |
Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex.
Topics: Animals; Blotting, Western; Calcium; Cerebral Cortex; Chronic Disease; Glutamic Acid; Immunohistochemistry; L-Lactate Dehydrogenase; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological; Synaptosomes; Tyrosine | 2000 |
Nitric oxide induces dose-dependent CA(2+) transients and causes temporal morphological hyperpolarization in human neutrophils.
Topics: Actins; Calcium; Calcium Signaling; Cell Adhesion; Cell Movement; Cell Size; Cyclic GMP; Dose-Response Relationship, Drug; Homeostasis; Humans; Indicators and Reagents; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Penicillamine; Tyrosine | 2000 |
Endothelial dysfunction and peroxynitrite formation are early events in angiotensin-induced cardiovascular disorders.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta, Thoracic; Cardiovascular Diseases; Endothelium, Vascular; Hemodynamics; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; Nitrates; Nitroprusside; Phenylephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Renin; Tyrosine; Vasoconstriction | 2000 |
Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model.
Topics: Animals; Cell Movement; Dinoprostone; Drug Combinations; Female; Fibrosarcoma; Gene Frequency; Genetic Variation; Immunohistochemistry; Injections; Injections, Subcutaneous; Interleukin-8; Mice; Mice, Inbred C57BL; Mutation; Neoplasm Transplantation; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tumor Cells, Cultured; Tyrosine | 2000 |
Neurotoxicity and oxidative damage of beta amyloid 1-42 versus beta amyloid 1-40 in the mouse cerebral cortex.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Deoxyguanosine; Free Radicals; Frontal Lobe; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; Microinjections; Neurotoxins; Peptide Fragments; Tyrosine | 1999 |
Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission.
Topics: Animals; Autoradiography; Brain; Cells, Cultured; DNA Damage; Enzyme Activation; Glutamic Acid; Immunohistochemistry; Kidney; Mice; Mice, Knockout; N-Methylaspartate; NAD; Nitric Oxide; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Proteins; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2000 |
Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion.
Topics: Acidosis; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Endothelium, Vascular; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Reperfusion Injury; Tyrosine | 2000 |
Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques.
Topics: Aged; Analysis of Variance; Arteriosclerosis; Biomarkers; Blotting, Western; Carotid Arteries; Ceroid; Endarterectomy, Carotid; Female; Humans; Immunohistochemistry; Lipid Peroxidation; Macrophages; Male; Microscopy, Electron; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 1999 |
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo.
Topics: Dimerization; Flavin Mononucleotide; Free Radicals; Hydrazines; Hypoxanthine; Kinetics; Nitrates; Nitric Oxide; Nitrogen Oxides; Spermine; Tyrosine; Xanthine Oxidase | 2000 |
Role of nitric oxide and peroxynitrite in bile salt-induced apoptosis: relevance to colon carcinogenesis.
Topics: Apoptosis; Bile Acids and Salts; Colonic Neoplasms; Deoxycholic Acid; Enzyme Inhibitors; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Salicylates; Superoxides; Tumor Cells, Cultured; Tyrosine | 1999 |
Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Body Weight; Cyclic N-Oxides; Disease Models, Animal; Enzyme Activation; Free Radical Scavengers; Joints; Kinetics; Male; Poly(ADP-ribose) Polymerases; Radiography; Rats; Rats, Inbred Lew; Severity of Illness Index; Spin Labels; Time Factors; Tyrosine | 2000 |
Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
Topics: Acetaminophen; Adjuvants, Immunologic; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cattle; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Hemocyanins; Immunoenzyme Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Nitrates; Protein Binding; Proteins; Rabbits; Serum Albumin, Bovine; Sodium Chloride; Tyrosine | 2000 |
Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.
Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydrazines; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Reactive Oxygen Species; Spermine; Superoxide Dismutase; Tyrosine; Vitamin K | 2000 |
Scavengers for peroxynitrite: inhibition of tyrosine nitration and oxidation with tryptamine derivatives, alpha-lipoic acid and synthetic compounds.
Topics: Antioxidants; Chromatography, High Pressure Liquid; DNA Damage; Free Radical Scavengers; Indicators and Reagents; Nitrates; Oxidation-Reduction; Plasmids; Spectrophotometry, Ultraviolet; Spin Trapping; Thioctic Acid; Tryptamines; Tyrosine | 2000 |
Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease.
Topics: Adult; Female; Hepatitis; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunologic Techniques; Liver; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Severity of Illness Index; Tissue Distribution; Tyrosine | 2000 |
Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy.
Topics: Animals; Carrageenan; Cells, Cultured; Cyclic N-Oxides; DNA Damage; Free Radical Scavengers; Hydrogen Peroxide; Lung; Macrophages; Male; Mitochondria; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxygen Consumption; Permeability; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spin Labels; Tyrosine | 2000 |
Role of hyperbaric oxygen exposure in reduction of lipid peroxidation and in multiple organ failure induced by zymosan administration in the rat.
Topics: Animals; Hyperbaric Oxygenation; Lipid Peroxidation; Male; Malondialdehyde; Multiple Organ Failure; Peritonitis; Peroxidase; Rats; Rats, Sprague-Dawley; Tyrosine; Zymosan | 2000 |
Do TNF-alpha-insensitive cancer cells escape alpha-tubulin nitrotyrosination?
Topics: Neoplasms; Nitric Oxide; Protein Processing, Post-Translational; Tubulin; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Diffusion of peroxynitrite into the human platelet inhibits cyclooxygenase via nitration of tyrosine residues.
Topics: Blood Platelets; Cell Membrane; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diffusion; Eicosanoids; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Membrane Proteins; Nitrates; Oxidants; Platelet Activation; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Tyrosine; Vasoconstriction | 2000 |
Expression of the inducible isoform of nitric oxide synthase in pigment cell lesions of the skin.
Topics: Biomarkers, Tumor; Disease Progression; Enzyme Induction; Humans; Isoenzymes; Macrophages; Melanoma; Neoplasm Metastasis; Nevus; Nitric Oxide Synthase; Skin Neoplasms; Tyrosine | 2000 |
Localization of inducible nitric oxide synthase to mast cells during ischemia/reperfusion injury of skeletal muscle.
Topics: Animals; Isoenzymes; Mast Cells; Muscle, Skeletal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Reperfusion Injury; Tyrosine | 2000 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Free Radical Scavengers; Mice; Multiple Sclerosis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Spinal Cord; Tyrosine; Uric Acid | 2000 |
Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination.
Topics: Animals; Astrocytes; Cell Culture Techniques; Cell Survival; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Fungal Proteins; Glyceraldehyde-3-Phosphate Dehydrogenases; HSP70 Heat-Shock Proteins; Hydrogen Peroxide; Molecular Chaperones; Nitrates; Oxidants; Rats; Rats, Wistar; Saccharomyces cerevisiae; Sulfhydryl Compounds; Sulfhydryl Reagents; Tyrosine; Ubiquitins; Up-Regulation | 2000 |
Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Angiotensin II; Antihypertensive Agents; Diabetes Mellitus, Type 1; Epoprostenol; Female; Fetus; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitroglycerin; Oxidative Stress; Placenta; Pre-Eclampsia; Pregnancy; Reactive Oxygen Species; Tyrosine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Increased production of nitrotyrosine in lung tissue of rats with radiation-induced acute lung injury.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Enzyme Induction; L-Lactate Dehydrogenase; Lung; Lung Diseases; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Proteins; Radiation Injuries, Experimental; Rats; Rats, Wistar; Tyrosine | 2000 |
Reactive nitrogen and oxygen species attenuate interleukin- 8-induced neutrophil chemotactic activity in vitro.
Topics: Chemotaxis, Leukocyte; Humans; Interleukin-8; Leukotriene B4; Molsidomine; Neutrophils; Nitrates; Nitric Oxide Donors; Tyrosine | 2000 |
Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases.
Topics: Adult; Aged; Alzheimer Disease; Antibodies; Biomarkers; Female; Humans; Male; Middle Aged; Nitrates; Nitrogen; Oxidative Stress; Parkinson Disease; Precipitin Tests; Superoxide Dismutase; Tyrosine | 2000 |
Peroxynitrite-mediated nitration of the stable free radical tyrosine residue of the ribonucleotide reductase small subunit.
Topics: Amino Acid Sequence; Catalysis; Chromatography, High Pressure Liquid; Conserved Sequence; Dimerization; Dose-Response Relationship, Drug; Escherichia coli; Free Radicals; Hydrogen-Ion Concentration; Mass Spectrometry; Models, Molecular; Molecular Weight; Nitrates; Nonheme Iron Proteins; Protein Structure, Quaternary; Ribonucleotide Reductases; Sequence Analysis, Protein; Spectrophotometry; Tyrosine | 2000 |
Hyperalgesia due to nerve injury-role of peroxynitrite.
Topics: Animals; Hyperalgesia; Hyperthermia, Induced; Immunohistochemistry; Male; Nerve Compression Syndromes; Nerve Crush; Nerve Degeneration; Neuralgia; Nitrates; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Rats, Wistar; Tyrosine; Uric Acid | 2000 |
Formation of N-nitrosamines and N-nitramines by the reaction of secondary amines with peroxynitrite and other reactive nitrogen species: comparison with nitrotyrosine formation.
Topics: Aniline Compounds; Hydrogen Peroxide; Hypochlorous Acid; Morpholines; Nitrates; Nitrobenzenes; Nitrosamines; Sodium Nitrite; Superoxides; Tyrosine | 2000 |
Role of the carbonate radical anion in tyrosine nitration and hydroxylation by peroxynitrite.
Topics: Anions; Bicarbonates; Carbon Dioxide; Carbonates; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-Ion Concentration; Hydroxyl Radical; Hydroxylation; Kinetics; Nitrates; Nitric Oxide; Spectrophotometry, Ultraviolet; Tyrosine | 2000 |
Nitrotyrosine in esophageal squamous cell carcinoma and relevance to p53 expression.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Tumor Suppressor Protein p53; Tyrosine | 2000 |
Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome.
Topics: Acute Disease; Adult; alpha 1-Antichymotrypsin; Blood Proteins; Blotting, Western; Carbon Dioxide; Ceruloplasmin; Enzyme Activation; Fibrinogen; Humans; In Vitro Techniques; Nitrates; Nitric Oxide; Oxidative Stress; Precipitin Tests; Respiratory Distress Syndrome; Superoxides; Tyrosine | 2000 |
Carbon dioxide enhances nitration of surfactant protein A by activated alveolar macrophages.
Topics: Carbon Dioxide; Cells, Cultured; Enzyme Activation; Epithelial Cells; Humans; Hypercapnia; Lipid Metabolism; Lipopolysaccharides; Macrophages, Alveolar; Mass Spectrometry; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Respiratory Distress Syndrome; Tyrosine | 2000 |
Temporal, regional, and cell-specific changes of iNOS expression after intrastriatal microinjection of interferon gamma and bacterial lipopolysaccharide.
Topics: Animals; Antineoplastic Agents; Astrocytes; Corpus Callosum; Corpus Striatum; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; Interferon-gamma; Lipopolysaccharides; Male; Microglia; Microinjections; Neuritis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2000 |
Is nitrotyrosine generated in human erythrocytes in circulation?
Topics: Aging; Animals; Antibodies; Erythrocyte Membrane; Erythrocytes; Hemoglobins; Humans; Membrane Proteins; Rabbits; Ribonuclease, Pancreatic; Tyrosine | 2000 |
IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment.
Topics: 6-Aminonicotinamide; Animals; Antigens, Differentiation; Astrocytes; Blood-Brain Barrier; Bone Marrow Cells; Brain Stem; Encephalitis; Glial Fibrillary Acidic Protein; Hematopoiesis; Immunohistochemistry; Interleukin-6; Macrophages; Malondialdehyde; Metallothionein; Metallothionein 3; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Tissue Proteins; Oxidative Stress; Protein Isoforms; Serum Albumin; T-Lymphocytes; Tyrosine | 2000 |
Determination of 3-nitrotyrosine by high-pressure liquid chromatography with a dual-mode electrochemical detector.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Oxidants; Proteins; Rats; Sensitivity and Specificity; Tetranitromethane; Tyrosine | 2000 |
Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy.
Topics: Adolescent; Adult; Aged; Child; Diabetic Nephropathies; Female; Humans; Immunohistochemistry; Kidney; Male; Middle Aged; Nitrates; Tyrosine | 2000 |
Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.
Topics: Animals; Antioxidants; Cells, Cultured; Chromatography, High Pressure Liquid; Enzymes; Free Radical Scavengers; Humans; Indicators and Reagents; Inflammation; Inflammatory Bowel Diseases; Lipoproteins, LDL; Lipoxygenase; Models, Biological; Nervous System Diseases; Oxidative Stress; Peroxidase; Plant Extracts; Plants, Medicinal; Respiratory Burst; Respiratory Tract Diseases; Tyrosine; Xanthine Oxidase | 2000 |
The nitration of platelet cytosolic proteins during agonist-induced activation of platelets.
Topics: Aspirin; Blood Platelets; Blood Proteins; Blotting, Western; Cell Adhesion Molecules; Collagen; Cyclooxygenase Inhibitors; Cytosol; Enzyme-Linked Immunosorbent Assay; Humans; Membrane Proteins; Microfilament Proteins; Molecular Weight; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrous Acid; Oxidants; Peroxynitrous Acid; Phosphoproteins; Platelet Activation; Thrombin; Tyrosine | 2000 |
Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated.
Topics: Animals; Apoptosis; Cats; Ileum; Immunohistochemistry; Intestinal Mucosa; Lipopolysaccharides; Male; Mitochondria; Multiple Organ Failure; Necrosis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen Consumption; Sepsis; Tyrosine | 2000 |
Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR.
Topics: Animals; Cyclic N-Oxides; Feedback; Hypertension; Indazoles; Kidney Glomerulus; Kidney Tubules; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Superoxide Dismutase; Superoxides; Tyrosine | 2000 |
A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis.
Topics: Animals; Catalysis; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Female; Ferric Compounds; Immunohistochemistry; Lymphocyte Transfusion; Lymphocytes; Metalloporphyrins; Mice; Mice, Inbred Strains; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2000 |
Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney.
Topics: Animals; Blood Urea Nitrogen; Blotting, Western; Creatine; Enzyme Inhibitors; Glutathione; Immunohistochemistry; Kidney; Lipid Peroxidation; Lipopolysaccharides; Lysine; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis; Female; Male; Motor Activity; Neurologic Examination; Neuroprotective Agents; Neutrophils; Nitrates; Poly(ADP-ribose) Polymerase Inhibitors; Polymers; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Stroke; Time Factors; Tyrosine | 2000 |
Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis.
Topics: Adult; Alternative Splicing; Arginine; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; DNA-Binding Proteins; Epithelial Cells; Female; Fluocinolone Acetonide; Humans; Interferon-gamma; Janus Kinase 1; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Reactive Oxygen Species; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tyrosine | 2000 |
Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Female; Humans; Male; Middle Aged; Tyrosine | 1999 |
Scavenging of peroxynitrite by oxyhemoglobin and identification of modified globin residues.
Topics: Ascorbic Acid; Carbon Dioxide; Dipeptides; Erythrocytes; Free Radical Scavengers; Globins; Humans; Immunoelectrophoresis; Mass Spectrometry; Nitrates; Oxyhemoglobins; Tyrosine | 2000 |
Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase.
Topics: Animals; Batroxobin; Enzyme Induction; Guanidines; Humans; Immunohistochemistry; Intracranial Aneurysm; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Oxygen-insensitive nitroreductases of Escherichia coli do not reduce 3-nitrotyrosine.
Topics: Bacterial Proteins; Cell Fractionation; Drug Resistance, Neoplasm; Enzyme Induction; Escherichia coli; Escherichia coli Proteins; Nitrates; Nitroreductases; Oxidation-Reduction; Oxygen; Paraquat; Peptides; Reducing Agents; Tyrosine | 2000 |
Immunohistochemical localization of protein 3-nitrotyrosine and S-nitrosocysteine in a murine model of inhaled nitric oxide therapy.
Topics: Administration, Inhalation; Animals; Cysteine; Epithelium; Female; Immunohistochemistry; Lung; Mice; Nitric Oxide; Nitroso Compounds; S-Nitrosothiols; Tyrosine | 2000 |
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Blood Pressure; Catalysis; Celiac Artery; Disease Models, Animal; Endothelium, Vascular; Ferric Compounds; Ileum; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhodamines; Splanchnic Circulation; Tyrosine | 2000 |
How urine analysis reflects oxidative stress--nitrotyrosine as a potential marker.
Topics: Adult; Ascorbic Acid; Biomarkers; Chromatography, Gas; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitroglycerin; Oxidative Stress; Reference Values; Tyrosine; Urinalysis | 2000 |
Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma.
Topics: Adenocarcinoma; Blotting, Western; Chromatography, High Pressure Liquid; Cortactin; Humans; Microfilament Proteins; Nitrates; Pancreatic Neoplasms; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Conformation; Protein Folding; Proto-Oncogene Proteins pp60(c-src); Tumor Cells, Cultured; Tyrosine | 2000 |
Protein nitration, metabolites of reactive nitrogen species, and inflammation in lung allografts.
Topics: Adult; Bronchiolitis Obliterans; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Female; Forced Expiratory Volume; Graft Rejection; Humans; Lung; Lung Transplantation; Male; Nitrates; Nitrites; Postoperative Complications; Prognosis; Tyrosine | 2000 |
Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation.
Topics: Animals; Bone Marrow Cells; Cell Communication; Enzyme Activation; Fluorescent Antibody Technique; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiation Dosage; Radiation, Ionizing; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells; Tyrosine | 2000 |
Inducible nitric oxide synthase and nitrotyrosine in the central nervous system of mice chronically infected with Trypanosoma brucei brucei.
Topics: Animals; Brain; Coloring Agents; Female; Fluorescent Antibody Technique; Immunohistochemistry; Mice; NADPH Dehydrogenase; Nervous System Diseases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Trypanosoma brucei brucei; Trypanosomiasis, African; Tyrosine | 2000 |
Ultrastructural localization of nitrotyrosine within the caudate-putamen nucleus and the globus pallidus of normal rat brain.
Topics: Animals; Astrocytes; Axons; Caudate Nucleus; Cell Nucleus; Cytoplasm; Dendrites; Globus Pallidus; Male; Microscopy, Immunoelectron; Mitochondria; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nuclear Envelope; Putamen; Rats; Rats, Sprague-Dawley; Tyrosine; Vacuoles | 2000 |
Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice.
Topics: Animals; Antibiotics, Antineoplastic; Creatine Kinase; Doxorubicin; Immunohistochemistry; Male; Mice; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine; Ventricular Dysfunction, Left | 2000 |
Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs.
Topics: Animals; Benzamides; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Escherichia coli Infections; Female; Hemodynamics; Immunohistochemistry; Lipopolysaccharides; Male; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proteins; Pulmonary Circulation; Respiratory Distress Syndrome; Respiratory Mechanics; Shock, Septic; Swine; Tyrosine | 2000 |
Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma; Antibodies, Monoclonal; Antioxidants; Bone Neoplasms; Catalase; Deoxyguanosine; Glutathione Peroxidase; Humans; Immunoenzyme Techniques; Lipofuscin; Male; Prostate; Prostatic Neoplasms; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2000 |
Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blood-Brain Barrier; Brain; Brain Ischemia; Caspase Inhibitors; Cattle; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Cytochrome c Group; DNA Fragmentation; Endothelium, Vascular; Free Radicals; Gene Expression Regulation, Enzymologic; Glucose; In Situ Nick-End Labeling; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxygen; RNA, Messenger; Sorbitol; Spin Labels; Thiocarbamates; Tyrosine | 2000 |
Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
Topics: Alanine Transaminase; Anemia, Sickle Cell; Animals; Apoptosis; Aspartate Aminotransferases; Blotting, Western; Cell Hypoxia; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Guanidines; Immunohistochemistry; In Situ Nick-End Labeling; Kidney Diseases; Kidney Tubules; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Poly(ADP-ribose) Polymerases; Tyrosine | 2000 |
Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock.
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Free Radical Scavengers; Kidney; Lipopolysaccharides; Liver; Lung; Male; Multiple Organ Failure; Multiple Trauma; Nitrates; Nitrites; Peptidoglycan; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Spin Labels; Staphylococcal Infections; Teichoic Acids; Tyrosine | 2000 |
Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production.
Topics: Ammonia; Anti-Bacterial Agents; Carbon Dioxide; Drug Interactions; Helicobacter pylori; Microbial Sensitivity Tests; Nitrates; Oxidants; Sodium Bicarbonate; Tyrosine; Urea; Urease | 2000 |
Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro.
Topics: Animals; Macrophage Activation; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phagocytosis; Reactive Oxygen Species; Salmonella typhimurium; Superoxides; Tyrosine | 2000 |
Beneficial effects of n-acetylcysteine on ischaemic brain injury.
Topics: Acetylcysteine; Animals; Brain; Brain Edema; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Male; Malondialdehyde; Motor Activity; Nitric Oxide; Peroxidase; Poly(ADP-ribose) Polymerases; Reperfusion Injury; Time Factors; Tyrosine | 2000 |
The determination of nitrotyrosine residues in proteins.
Topics: Animals; Antibodies; Immunohistochemistry; Indicators and Reagents; Mice; Proteins; Radioimmunoassay; Rats; Tyrosine | 1998 |
Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament; Apoptosis; Cartilage; Cell Count; Chondrocytes; Hyaluronic Acid; Knee Joint; Nitric Oxide; Osteoarthritis, Knee; Rabbits; Tyrosine | 2000 |
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
Topics: Acute Kidney Injury; Animals; Cell Membrane Permeability; Cell Separation; Cells, Cultured; Chelating Agents; Cyclic N-Oxides; Deferoxamine; Disease Models, Animal; Free Radical Scavengers; Hydrogen Peroxide; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Malondialdehyde; Necrosis; Oxidants; Oxidative Stress; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reperfusion Injury; Spin Labels; Tyrosine | 2000 |
Reactions of peroxynitrite with cocoa procyanidin oligomers.
Topics: Biflavonoids; Cacao; Catechin; Chromatography, High Pressure Liquid; Drug Interactions; Nitrates; Oxidants; Oxidation-Reduction; Proanthocyanidins; Rhodamines; Structure-Activity Relationship; Tyrosine | 2000 |
Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum.
Topics: Adolescent; Adult; Cystic Fibrosis; Female; Free Radicals; Humans; Inflammation; Male; Nitrates; Nitric Oxide; Sputum; Superoxides; Tyrosine | 2000 |
Immunolocalization of inducible nitric oxide synthase and 3-nitrotyrosine in the nasal mucosa of patients with rhinitis.
Topics: Adolescent; Adult; Enzyme Induction; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nasal Mucosa; Nitrates; Nitric Oxide Synthase; Rhinitis; Rhinitis, Allergic, Perennial; Turbinates; Tyrosine | 2000 |
Physiological effects of peroxynitrite: potential products of the environment.
Topics: Animals; Blood Physiological Phenomena; Cats; Crystalloid Solutions; Cytokines; Glutathione; Heart; Heart Diseases; Heart Ventricles; Humans; Isotonic Solutions; Myocardial Infarction; Nitrates; Nitric Oxide; Perfusion; Plasma Substitutes; Superoxides; Tyrosine | 2000 |
Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Coloring Agents; Endothelium, Vascular; Enzyme Inhibitors; Evans Blue; Indazoles; Infarction, Middle Cerebral Artery; Matrix Metalloproteinase 9; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidants; Permeability; Reperfusion Injury; Tyrosine | 2000 |
Accumulation of nitrotyrosine correlates with endothelial NO synthase in pulmonary resistance arteries during chronic hypoxia in the rat.
Topics: Actins; Animals; Arteries; Endothelium; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Lung; Nitric Oxide Synthase; Rats; Tyrosine; Vascular Resistance | 2000 |
Immature brain injury via peroxynitrite production induced by inducible nitric oxide synthase after hypoxia-ischemia in rats.
Topics: Animals; Animals, Newborn; Brain Diseases; Carotid Arteries; Hypoxia-Ischemia, Brain; Kinetics; Ligation; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2000 |
Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways.
Topics: Adult; Asthma; Cell Count; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Lung; Lung Diseases, Obstructive; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sputum; Tyrosine | 2000 |
Periadventitial inducible nitric oxide synthase expression and intimal thickening.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Pressure; Body Weight; Carotid Arteries; Enzyme Inhibitors; Gene Expression; Immunohistochemistry; Leukosialin; Macrophages; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; T-Lymphocytes; Tyrosine | 2000 |
Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apoptosis; DNA Damage; Endothelium, Vascular; Image Interpretation, Computer-Assisted; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Male; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Tyrosine; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Nitric oxide synthase and tissue injury.
Topics: Alprostadil; Animals; Arginine; Burns; Enzyme Inhibitors; Humans; Ischemia; Luminescent Measurements; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Reperfusion Injury; Sepsis; Shock; Superoxides; Tyrosine | 2000 |
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
Topics: Alanine; Apoptosis; Binding Sites; Caspase 1; Caspase 3; Caspase 6; Caspase 7; Caspase 8; Caspase 9; Caspases; Catalysis; Escherichia coli; Fluorescent Dyes; Glycine; Humans; Kinetics; Models, Molecular; ortho-Aminobenzoates; Peptides; Protein Binding; Proteins; Recombinant Proteins; Serine; Substrate Specificity; Tyrosine | 2000 |
Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia.
Topics: Acetylcholine; Animals; Aorta; Arteriosclerosis; Cystathionine beta-Synthase; Dinoprost; Disease Models, Animal; Endothelium, Vascular; F2-Isoprostanes; Heterozygote; Humans; Hyperhomocysteinemia; In Vitro Techniques; Lipid Peroxides; Mice; Mice, Mutant Strains; Nitroprusside; Reactive Oxygen Species; Risk Factors; Thrombosis; Tyrosine; Vasodilation | 2000 |
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Blood Volume; Dinoprost; Enzyme Activation; Hemodynamics; In Vitro Techniques; Intestinal Mucosa; Liver; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Peroxidase; Poly(ADP-ribose) Polymerases; Resuscitation; Shock, Hemorrhagic; Sodium Chloride; Tyrosine | 2000 |
Myeloperoxidase and protein oxidation in cystic fibrosis.
Topics: Adult; Bronchi; Case-Control Studies; Cell Line; Chromatography, High Pressure Liquid; Cystic Fibrosis; Drug Synergism; Humans; Hydrogen Peroxide; Nitrates; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxidases; Proteins; Respiratory System; Sputum; Trachea; Tyrosine | 2000 |
Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis.
Topics: Animals; Benzamides; Chronic Disease; Colitis; Disease Models, Animal; Energy Metabolism; Enzyme Inhibitors; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Intestinal Absorption; Intestinal Mucosa; Mice; Mice, Inbred Strains; Mice, Knockout; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Anterior Horn Cells; Astrocytes; Axons; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Lumbosacral Region; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyramidal Tracts; Tyrosine | 2000 |
P-selectin participates in cardiopulmonary bypass-induced inflammatory response in association with nitric oxide and peroxynitrite production.
Topics: Animals; Antibodies, Monoclonal; Cardiopulmonary Bypass; Inflammation; Interleukin-6; Male; Nitrates; Nitric Oxide; Nitrites; P-Selectin; Rats; Rats, Sprague-Dawley; Tyrosine | 2000 |
Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury.
Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Aorta; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; Ileum; In Vitro Techniques; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipid Peroxidation; Male; Malondialdehyde; Nitrates; Nitrites; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splenic Artery; Tyrosine; Vasodilation | 2000 |
Evidence for oxidative stress in experimental prion disease.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Membrane Proteins; Mice; Oxidative Stress; Prion Diseases; Tyrosine | 2000 |
Nitric oxide indices in human septic shock.
Topics: Adolescent; Adult; Humans; Nitrates; Nitric Oxide; Nitrites; Prospective Studies; Severity of Illness Index; Shock, Septic; Sulfhydryl Compounds; Tyrosine | 2000 |
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Cerebral Arteries; Cyclic N-Oxides; Free Radical Scavengers; Gerbillinae; Hippocampus; Lipid Peroxides; Male; Malondialdehyde; Motor Activity; Neutrophil Infiltration; Nitrates; Nitrites; Peroxidase; Poly(ADP-ribose) Polymerases; Reperfusion Injury; Spin Labels; Survival Analysis; Tyrosine | 2000 |
Dietary arginine alters time of symptom onset in Huntington's disease transgenic mice.
Topics: Animals; Arginine; Blood Glucose; Brain; Cerebrovascular Circulation; Diet; Huntington Disease; Mice; Mice, Transgenic; Movement Disorders; Time Factors; Tyrosine; Weight Loss | 2000 |
Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate.
Topics: Air Pollutants; Amino Acids, Cyclic; Chromatography, High Pressure Liquid; Guanine; HL-60 Cells; Humans; Hydroxylation; Mass Spectrometry; Nitrates; Nitrogen; Oxidants; Peracetic Acid; Phenylalanine; Tryptophan; Tyrosine | 2000 |
Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity.
Topics: Cells, Cultured; Endothelium, Vascular; Free Radicals; Humans; Intercellular Adhesion Molecule-1; Nitrates; Nitric Oxide; Nitrites; Potassium Dichromate; RNA, Messenger; Superoxides; Tyrosine | 2000 |
Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet.
Topics: Animals; Arginine; Biomarkers; Blood Pressure; Body Weight; Dietary Carbohydrates; Dietary Fats; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Tyrosine | 2000 |
Effects of homocysteine on endothelial nitric oxide production.
Topics: Animals; Arginine; Bradykinin; Calcimycin; Cells, Cultured; Endothelium, Vascular; Folic Acid; Free Radical Scavengers; Homocysteine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Reactive Oxygen Species; Recombinant Proteins; Superoxides; Tyrosine | 2000 |
Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits.
Topics: Animals; Brain; Enzyme Inhibitors; Guanidines; Immunoenzyme Techniques; Male; Malondialdehyde; Meningitis, Bacterial; Meningitis, Meningococcal; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peroxidase; Proteins; Rabbits; Streptococcal Infections; Streptococcus agalactiae; Tyrosine | 2000 |
Incorporation of nitrotyrosine into alpha-tubulin by recombinant mammalian tubulin-tyrosine ligase.
Topics: Amino Acid Sequence; Animals; Brain; Cells, Cultured; Escherichia coli; Peptide Synthases; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tubulin; Tyrosine | 2000 |
The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat.
Topics: Animals; Body Weight; Colitis; Cyclooxygenase 2; Cytokines; Enzyme Inhibitors; Isoenzymes; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrosine; Tyrphostins | 2000 |
Tempol, a membrane-permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Benzenesulfonates; Body Weight; Cell Membrane Permeability; Colitis; Colon; Cyclic N-Oxides; Free Radical Scavengers; Immunohistochemistry; Intestinal Mucosa; Lipid Peroxidation; Male; Neutrophil Infiltration; Organ Size; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spin Labels; Spleen; Survival Rate; Tyrosine | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; Immunoassay; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thiocarbamates; Tyrosine; Vasodilation | 2000 |
Oxidative protein damage in type I diabetic patients with and without complications.
Topics: Adult; Blood Proteins; Ceruloplasmin; Diabetes Mellitus, Type 1; Erythrocytes; Female; Fructosamine; Glutathione; Glycated Hemoglobin; Humans; Iron; Lipid Peroxides; Male; Oxidative Stress; Protein Binding; Sulfhydryl Compounds; Transferrin; Tyrosine | 2000 |
Application of chemically induced dynamic nuclear polarization to the nitration of N-acetyltyrosine and to some reactions of peroxynitrite.
Topics: Absorption; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrates; Nitric Acid; Nitrites; Nitrobenzenes; Nitrogen Isotopes; Tyrosine | 2000 |
Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease.
Topics: Blotting, Western; Enzyme Induction; Female; Humans; Hydrogen Peroxide; Male; Middle Aged; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry; Tyrosine | 2000 |
Increased nitrotyrosine in exhaled breath condensate of patients with asthma.
Topics: Adult; Asthma; Breath Tests; Female; Humans; Leukotrienes; Lung; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Tyrosine | 2000 |
The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein.
Topics: Amino Acids; Animals; Immunohistochemistry; Male; Models, Biological; Nitrates; Nitric Oxide; Nitroarginine; Proteins; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Superoxide Dismutase; Tyrosine; Wounds, Nonpenetrating | 2000 |
Glutathione S-transferase pi in squamous cell carcinoma of the head and neck.
Topics: Adult; Carcinoma, Squamous Cell; Glutathione S-Transferase pi; Glutathione Transferase; Head and Neck Neoplasms; Humans; Immunohistochemistry; Isoenzymes; Middle Aged; Mouth Mucosa; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Tyrosine; Up-Regulation | 2000 |
Role of nitric oxide and superoxide in acute cardiac allograft rejection in rats.
Topics: Acute Disease; Animals; Electron Spin Resonance Spectroscopy; Graft Rejection; Heart Transplantation; In Vitro Techniques; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Perfusion; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Superoxide Dismutase; Superoxides; Transplantation, Homologous; Tyrosine | 2000 |
Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway.
Topics: Animals; Apoptosis; Carbon Dioxide; Cells, Cultured; Cytokines; Fetus; Hypercapnia; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pulmonary Alveoli; Rats; Respiratory Mucosa; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
Topics: alpha-Synuclein; Alzheimer Disease; Antibodies, Monoclonal; Blotting, Western; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Lewy Bodies; Lewy Body Disease; Microscopy, Immunoelectron; Multiple System Atrophy; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidative Stress; Parkinson Disease; Synucleins; Tyrosine | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scavengers; Gerbillinae; Immunoenzyme Techniques; Male; Malondialdehyde; Melatonin; Motor Activity; Nitrates; Nitrites; Oxidative Stress; Peroxidase; Poly(ADP-ribose) Polymerases; Reperfusion Injury; Tyrosine | 2000 |
Inducible nitric oxide synthase-knockout mice exhibit resistance to pleurisy and lung injury caused by carrageenan.
Topics: Animals; Carrageenan; Cells, Cultured; DNA Damage; Enzyme Activation; Exudates and Transudates; Immunohistochemistry; Lipid Peroxidation; Lung; Macrophages; Male; Malondialdehyde; Mice; Mice, Knockout; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Pleura; Pleurisy; Poly(ADP-ribose) Polymerases; Tyrosine | 2000 |
Cyclophosphamide prevents systemic keratinocyte growth factor-induced up-regulation of surfactant protein A after allogeneic transplant in mice.
Topics: Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Female; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances; Immunosuppressive Agents; Interleukin-2; Keratinocytes; Lung Diseases; Lymphocyte Culture Test, Mixed; Lymphocyte Depletion; Mice; Mice, Inbred Strains; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; T-Lymphocytes; Transplantation Conditioning; Tyrosine; Up-Regulation | 2000 |
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Antibodies; Blotting, Western; Brain Diseases; Female; Humans; Immunohistochemistry; Inclusion Bodies; Lewy Bodies; Male; Middle Aged; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglia; Nitrates; Synucleins; Tissue Distribution; Tyrosine | 2000 |
Mechanism for the peroxynitrite scavenging activity by anthocyanins.
Topics: Anthocyanins; Chromatography, High Pressure Liquid; Free Radical Scavengers; Kinetics; Nitrates; Nitrobenzoates; Oxidants; Parabens; Tyrosine | 2000 |
Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite. Stopped-flow measurements prove ferryl intermediates.
Topics: Animals; Bacillus; Bacterial Proteins; Binding Sites; Blotting, Western; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dithiothreitol; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Inhibitory Concentration 50; Iron; Mass Spectrometry; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molsidomine; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitric Oxide Donors; Nitrogen; Oxygen; Superoxide Dismutase; Temperature; Time Factors; Tyrosine; Uric Acid | 2000 |
Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite.
Topics: Acute Disease; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Binding Sites, Antibody; Complement C1q; Complement C3; Female; Free Radicals; Gout; Humans; Hydrogen Peroxide; Hypochlorous Acid; Immunoglobulin G; Male; Neutrophils; Nitrates; Osteoarthritis; Oxidation-Reduction; Oxygen; Rabbits; Receptors, IgG; Serum Albumin, Bovine; Synovial Fluid; Tyrosine | 2000 |
Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome.
Topics: Adolescent; Adult; Aged; Amyloid beta-Peptides; Cerebral Cortex; Child; Child, Preschool; Down Syndrome; Guanosine; Humans; Middle Aged; Neurons; Oxidative Stress; Tyrosine | 2000 |
Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats.
Topics: Animals; Arthritis; Body Weight; Cattle; Chromonar; Collagen; Cyclooxygenase 2; Disease Progression; Enzyme Activation; Hindlimb; Interleukin-1; Isoenzymes; Male; Malondialdehyde; Nitric Oxide; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Radiography; Rats; Rats, Inbred Lew; Severity of Illness Index; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucosa before and after Helicobacter pylori eradication.
Topics: Adult; Aged; Aged, 80 and over; Biopsy; Cyclooxygenase 2; Endoscopy; Gastric Mucosa; Gastritis; Helicobacter pylori; Humans; Immunohistochemistry; Isoenzymes; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Tyrosine; Ulcer; Urease | 2000 |
Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity.
Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Endoglin; Female; Hepatitis; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lectins, C-Type; Liver; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Obesity; Prognosis; Receptors, Cell Surface; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2000 |
GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis.
Topics: Adult; Endometriosis; Endometrium; Epithelial Cells; Female; Follicular Phase; Gonadotropin-Releasing Hormone; Humans; Luteal Phase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Stromal Cells; Tyrosine | 2000 |
Calpain inhibitor I reduces the development of acute and chronic inflammation.
Topics: Acute Disease; Animals; Arthritis; Carrageenan; Chronic Disease; Collagen; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Glycoproteins; Isoenzymes; Lung; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pleurisy; Poly Adenosine Diphosphate Ribose; Prostaglandin-Endoperoxide Synthases; Radiography; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Tarsus, Animal; Tyrosine | 2000 |
Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure.
Topics: Abortion, Spontaneous; Arteries; Drug Residues; Female; HSP70 Heat-Shock Proteins; Humans; Mitochondria; Oxidative Stress; Oxidoreductases; Oxygen; Partial Pressure; Placenta; Pregnancy; Pregnancy Trimester, First; Regional Blood Flow; RNA, Messenger; Tyrosine | 2000 |
Oxidative protein damage in early stage Type 1 diabetic patients.
Topics: Adolescent; Adult; Antioxidants; Blood Pressure; Blood Proteins; Ceruloplasmin; Child; Diabetes Mellitus, Type 1; Erythrocytes; Female; Glutathione; Glycated Hemoglobin; Humans; Lipid Peroxides; Lipids; Male; Oxidative Stress; Reference Values; Sulfhydryl Compounds; Superoxide Dismutase; Transferrin; Tyrosine | 2000 |
Myocardial cell death in human diabetes.
Topics: Angiotensin II; Apoptosis; Cardiomegaly; Diabetes Mellitus, Type 2; Female; Heart Failure; Humans; Hypertension; Male; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Renin-Angiotensin System; Tyrosine | 2000 |
Okadaic acid-induced upregulation of nitrotyrosine and heme oxygenase-1 in rat cortical neuron cultures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Neurons; Okadaic Acid; Phosphorylation; Rats; Tyrosine; Up-Regulation | 2001 |
Peroxynitrite formation in the orbit of diabetics with rhinocerebral mucormycosis.
Topics: Adolescent; Adult; Aged; Brain Diseases; Diabetes Mellitus; Eye Infections, Fungal; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Mucormycosis; Nitrates; Orbital Diseases; Paranasal Sinus Diseases; Respiratory Burst; Tyrosine | 2000 |
Enhanced peroxynitrite formation is associated with vascular aging.
Topics: Acetylcholine; Aging; Animals; Aorta; Body Weight; Calcimycin; Cellular Senescence; Endothelium, Vascular; Enzyme Induction; Hemodynamics; Male; Microscopy, Immunoelectron; Mitochondria; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Rats; Rats, Inbred Strains; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation | 2000 |
LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels.
Topics: Animals; Brain; Chromatography, Liquid; Mass Spectrometry; Microcirculation; Microscopy, Phase-Contrast; Nitrates; Rats; Rats, Wistar; Sensitivity and Specificity; Tyrosine | 2000 |
Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase.
Topics: Animals; Antioxidants; Biomarkers; Bronchoalveolar Lavage Fluid; Cytokines; Female; Gene Expression Regulation, Enzymologic; Glutathione Disulfide; Humans; Influenza A virus; Influenza, Human; Lung; Male; Mice; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Pneumonia, Viral; Pulmonary Edema; RNA, Messenger; Superoxide Dismutase; Thromboxane B2; Tyrosine | 2001 |
Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice.
Topics: Animals; Endothelial Growth Factors; Enzyme Inhibitors; Humans; Hyperoxia; Infant, Newborn; Lymphokines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.
Topics: Blood; Cell Line; Cell Movement; Complement Activation; Deferoxamine; Dithiothreitol; Embryo, Mammalian; Fibroblasts; Fibronectins; Humans; Lung; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrogen; Reactive Oxygen Species; Reducing Agents; Superoxides; Tyrosine; Xanthine Oxidase | 2001 |
The role of nitric oxide in bradycardia of rats with obstructive cholestasis.
Topics: Alanine Transaminase; Animals; Arginine; Bradycardia; Cholestasis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; gamma-Glutamyltransferase; Heart Atria; Heart Rate; In Vitro Techniques; Male; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Tyrosine; Vasoconstrictor Agents | 2001 |
Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Brain; Fluorescent Antibody Technique; Humans; Immunohistochemistry; In Situ Hybridization; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Tyrosine | 2000 |
Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries.
Topics: Aged; Aged, 80 and over; Apoptosis; Coronary Artery Disease; Coronary Vessels; Fas Ligand Protein; fas Receptor; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Male; Membrane Glycoproteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2000 |
Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival.
Topics: Adolescent; Adult; Female; Humans; Immunohistochemistry; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prognosis; Time Factors; Treatment Outcome; Tyrosine | 2000 |
Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arterial Occlusive Diseases; Catalysis; Cytokines; Fluorescent Antibody Technique; Ileum; Leukocyte Count; Male; Malondialdehyde; Manganese; Nitrates; Nitrites; Organometallic Compounds; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splanchnic Circulation; Superoxide Dismutase; Superoxides; Tyrosine | 2001 |
Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase.
Topics: Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotoxins; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Reference Values; Superoxide Dismutase; Tyrosine | 2001 |
Adenovirus infection increases iNOS and peroxynitrite production in the lung.
Topics: Adenoviridae Infections; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Female; Immunohistochemistry; Lung; Male; Mice; Mice, Inbred BALB C; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Surfactants; Tyrosine | 2001 |
Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric oxide.
Topics: Animals; Blotting, Western; Cell Line; Densitometry; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Lipopolysaccharides; Macrophage Activation; Macrophages; Methionine; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 2001 |
Is ceruloplasmin an important catalyst for S-nitrosothiol generation in hypercholesterolemia?
Topics: Apolipoproteins B; Ascorbic Acid; Catalysis; Ceruloplasmin; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Humans; Hydrogen Peroxide; Hypercholesterolemia; Lipoproteins, LDL; Mercaptoethanol; Nitrates; Nitrites; Nitroso Compounds; S-Nitrosothiols; Tyrosine; Uric Acid; Vitamin E | 2001 |
No evidence of NO-induced damage in potential donor organs after brain death.
Topics: Animals; Biomarkers; Brain Death; Chromatography, High Pressure Liquid; Heart Transplantation; Hemodynamics; Lipid Peroxidation; Liver; Liver Transplantation; Male; Multiple Organ Failure; Myocardium; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Wistar; Thiobarbiturates; Tissue Donors; Tyrosine | 2001 |
N-methyl-D-aspartate receptor antagonist reduces nitrotyrosine formation in caudate-putamen in rat focal cerebral ischemia-reperfusion.
Topics: Animals; Brain Ischemia; Calcium Channels; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Neostriatum; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Tyrosine | 2001 |
Melatonin reduces dinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Colon; Dinitrofluorobenzene; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; Immunohistochemistry; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Melatonin; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; P-Selectin; Peroxidase; Poly Adenosine Diphosphate Ribose; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Antioxidative properties of phenolic antioxidants isolated from corn steep liquor.
Topics: Acetates; Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Erythrocyte Membrane; Fermentation; Lipoproteins; Magnetic Resonance Spectroscopy; Nitrates; Phenols; Rabbits; Tyrosine; Vitamin E; Zea mays | 2001 |
Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat.
Topics: Analysis of Variance; Animals; Cyclic N-Oxides; Free Radical Scavengers; In Vitro Techniques; Intestine, Small; Liver; Lung; Male; Multiple Organ Failure; Poly(ADP-ribose) Polymerases; Random Allocation; Rats; Rats, Sprague-Dawley; Spin Labels; Statistics, Nonparametric; Tyrosine; Zymosan | 2001 |
Is *NO news bad news in acute respiratory distress syndrome?
Topics: Humans; Lung; Nitric Oxide; Prognosis; Respiratory Distress Syndrome; Tyrosine | 2001 |
Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome.
Topics: Adult; Bronchoalveolar Lavage Fluid; Female; Follow-Up Studies; Humans; Intensive Care Units; Macrophages, Alveolar; Male; Middle Aged; Nitric Oxide; Positive-Pressure Respiration; Reference Values; Respiratory Distress Syndrome; Tyrosine | 2001 |
Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis.
Topics: Aldehydes; Amyotrophic Lateral Sclerosis; Antioxidants; Cell Division; Cell Line; Cell Survival; Down Syndrome; Gene Expression; Glutathione; Glutathione Disulfide; Guanine; Humans; Ketones; Lipid Peroxidation; Mutation; Neuroblastoma; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Teratocarcinoma; Transfection; Tyrosine | 2001 |
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.
Topics: 1-Methyl-4-phenylpyridinium; Aldehydes; alpha-Synuclein; Cell Division; Cell Line; Cell Survival; Clone Cells; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression; Glutathione; Guanine; Humans; Hydrogen Peroxide; Ketones; Lipid Peroxidation; Mitochondria; Mutation; Nerve Tissue Proteins; Neuroblastoma; Oxidants; Oxidative Stress; Parkinsonian Disorders; Synucleins; Teratocarcinoma; Transfection; Tyrosine | 2001 |
Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats.
Topics: Aging; Animals; Blotting, Western; Central Nervous System; Cerebellum; Cyclic N-Oxides; Free Radical Scavengers; Hippocampus; Immunohistochemistry; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxygen; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Tyrosine; Up-Regulation | 2001 |
Protein nitration.
Topics: Animals; Dogs; Hypertension; Immunohistochemistry; In Vitro Techniques; Male; Mice; Proteins; Rats; Rats, Inbred SHR; Tissue Distribution; Tyrosine | 2000 |
Expression of nitric oxide synthases and nitrotyrosine during blood-brain barrier breakdown and repair after cold injury.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cold Temperature; Gene Expression; Immunohistochemistry; Male; Neovascularization, Pathologic; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Tyrosine | 2001 |
Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis.
Topics: Aging; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Collagen; Cysteine Endopeptidases; DNA Fragmentation; Gene Expression Regulation, Enzymologic; Image Processing, Computer-Assisted; In Situ Nick-End Labeling; Male; Multienzyme Complexes; Muscle, Smooth; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Penis; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tyrosine; Ubiquitins | 2001 |
Nitrated and oxidized plasma proteins in smokers and lung cancer patients.
Topics: Aged; Aged, 80 and over; Blood Proteins; Blotting, Western; Female; Humans; Immunoblotting; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Nitrates; Oxidation-Reduction; Precipitin Tests; Smoking; Tyrosine | 2001 |
Selective iNOS inhibition prevents hypotension in septic rats while preserving endothelium-dependent vasodilation.
Topics: Acetylcholine; Animals; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Hypotension; Lipopolysaccharides; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sepsis; Survival Rate; Tyrosine; Vasodilation | 2001 |
NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response.
Topics: Adult; Antigens; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Case-Control Studies; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Tyrosine | 2001 |
Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain.
Topics: Aging; Animals; Brain; Lipid Peroxidation; Male; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Sulfhydryl Compounds; Tyrosine | 2001 |
Endogenous and new synthetic antioxidants for peroxynitrite: selective inhibitory effect of 5-methoxytryptamine and lipoic acid on tyrosine nitration by peroxynitrite.
Topics: 5-Methoxytryptamine; Antioxidants; Chromatography, High Pressure Liquid; Dopamine Agents; Levodopa; Nitrates; Oxidants; Oxidation-Reduction; Proline; Pyrrolidines; Thioctic Acid; Tyrosine | 1999 |
Biochemistry of neurodegeneration.
Topics: Antibodies, Monoclonal; Brain; Humans; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oxidative Stress; Synucleins; Tyrosine | 2001 |
Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.
Topics: Animals; Creatine Kinase; Creatine Kinase, MM Form; Heart Failure; Image Processing, Computer-Assisted; Immunohistochemistry; Isoenzymes; Male; Myofibrils; Myosins; Nitrates; Oxidants; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
In vitro production of peroxynitrite by haemocytes from marine bivalves: C-ELISA determination of 3-nitrotyrosine level in plasma proteins from Mytilus galloprovincialis and Crassostrea gigas.
Topics: Animals; Antibodies, Monoclonal; Bivalvia; Blood Proteins; Enzyme-Linked Immunosorbent Assay; Hemocytes; Ostreidae; Peroxynitrous Acid; Phagocytosis; Reference Standards; Tyrosine | 2001 |
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.
Topics: Adult; Aged; Case-Control Studies; Catalase; Cyclic GMP; Diabetes Mellitus, Type 2; Erythrocytes; Female; Glutathione Peroxidase; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Reactive Oxygen Species; Selenium; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2001 |
Lead-induced hypertension. III. Increased hydroxyl radical production.
Topics: Animals; Blood Pressure; Free Radical Scavengers; Hydroxyl Radical; Hypertension; Lead; Lipid Peroxides; Male; Rats; Rats, Sprague-Dawley; Thiourea; Tyrosine | 2001 |
Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat.
Topics: Adenosine Diphosphate Ribose; Analysis of Variance; Animals; Cysteine Proteinase Inhibitors; Dinitrobenzenes; Glycoproteins; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; P-Selectin; Peroxidase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonic Acids; Tyrosine; Up-Regulation | 2001 |
Peroxynitrite inhibits the activity of ornithine decarboxylase.
Topics: Animals; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Nitrates; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidants; Rats; Recombinant Proteins; Tyrosine | 2001 |
Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Ischemic Attack, Transient; Male; Middle Cerebral Artery; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Reference Values; Superoxides; Tamoxifen; Tyrosine | 2001 |
Effect of peroxynitrite on motor function of the opossum esophagus.
Topics: Animals; Enzyme Inhibitors; Esophagitis; Esophagogastric Junction; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitrates; Opossums; Oxadiazoles; Oxidants; Oxyhemoglobins; Quinoxalines; Tyrosine | 2001 |
ONO1714, a new inducible nitric oxide synthase inhibitor, attenuates sepsis-induced diaphragmatic dysfunction in hamsters.
Topics: Amidines; Animals; Cricetinae; Diaphragm; Enzyme Inhibitors; Heterocyclic Compounds, 2-Ring; Immunohistochemistry; In Vitro Techniques; Malondialdehyde; Mesocricetus; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Respiration Disorders; Sepsis; Tyrosine | 2001 |
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells.
Topics: Aniline Compounds; Animals; Antioxidants; Blotting, Western; Cattle; Cell Death; Enzyme Inhibitors; Epithelial Cells; Female; Free Radical Scavengers; Histidine; L-Lactate Dehydrogenase; Lipopolysaccharides; Mammary Glands, Animal; Molsidomine; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidants; Peroxidase; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease.
Topics: Animals; Aorta; Arteriosclerosis; Diabetes Mellitus, Experimental; Glucose; Glycated Hemoglobin; Hydroxyl Radical; Lipids; Macaca fascicularis; Male; Mass Spectrometry; Oxidation-Reduction; Time Factors; Tyrosine | 2001 |
Involvement of nitric oxide in chondrocyte cell death in chondro-osteophyte formation.
Topics: Aged; Aged, 80 and over; Apoptosis; Chondrocytes; Cohort Studies; Hip Joint; Humans; Hypertrophy; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis, Hip; RNA, Messenger; Tyrosine | 2001 |
Oxidative stress and disturbed glutamate transport in hereditary nucleotide repair disorders.
Topics: Adolescent; Adult; Aldehydes; Amino Acid Transport System X-AG; ATP-Binding Cassette Transporters; Biological Transport; Child; Cockayne Syndrome; DNA Repair; Female; Glutamic Acid; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Neuroglia; Neurons; Oxidative Stress; Proteins; Tyrosine; Xeroderma Pigmentosum | 2001 |
Mitochondrial abnormalities in Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cerebellum; Child; Child, Preschool; DNA, Mitochondrial; Electron Transport Complex IV; Frontal Lobe; Guanosine; Hippocampus; Humans; Immunohistochemistry; In Situ Hybridization; Microscopy, Electron; Middle Aged; Mitochondria; Neurons; Oxidative Stress; Temporal Lobe; Tyrosine | 2001 |
Nitrotyrosine immunostaining correlates with increased extracellular matrix: evidence of postplacental hypoxia.
Topics: Adult; Diabetes Mellitus, Type 1; Embolism, Amniotic Fluid; Extracellular Matrix; Female; Fetal Death; Gestational Age; Humans; Hypoxia; Infant, Newborn; Placenta; Placental Circulation; Pre-Eclampsia; Pregnancy; Retrospective Studies; Tyrosine | 2001 |
Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species.
Topics: Eosinophil Peroxidase; Eosinophils; Free Radicals; Humans; Immunohistochemistry; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Oxidants; Oxidation-Reduction; Peroxidases; Phenylpropionates; Proteins; Reactive Oxygen Species; Status Asthmaticus; Tyrosine | 2001 |
Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro.
Topics: Animals; Base Sequence; Cell Line; DNA Primers; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Hydrazines; Lung; Mice; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; RNA, Messenger; Tyrosine | 2001 |
Hypoxia-ischemia in fetal rabbit brain increases reactive nitrogen species production: quantitative estimation of nitrotyrosine.
Topics: Animals; Brain Injuries; Brain Ischemia; Female; Fetal Hypoxia; Fetus; Free Radicals; Hypoxia, Brain; Placental Insufficiency; Pregnancy; Rabbits; Reperfusion Injury; Tyrosine | 2001 |
Nitric oxide and protein nitration are eosinophil dependent in allergen-challenged mice.
Topics: Analysis of Variance; Animals; Antibodies; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Eosinophils; Interleukin-5; Lung; Male; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrosation; Ovalbumin; Time Factors; Tyrosine | 2001 |
Role of reactive nitrogen species in neuronal cell damage during intestinal schistosomiasis.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Caspases; Enteric Nervous System; Eosinophilic Granuloma; Free Radicals; Ileum; Immunohistochemistry; Male; Mast Cells; Mice; Myenteric Plexus; Neurons; Schistosomiasis mansoni; Sexual Maturation; Time Factors; Tyrosine | 2001 |
Analysis of peptides and proteins containing nitrotyrosine by matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Hydrolysis; Oxidation-Reduction; Peptides; Proteins; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2001 |
Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats.
Topics: Administration, Oral; Administration, Topical; Animals; Biomarkers; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; DEET; Drug Interactions; Insect Repellents; Insecticides; Military Personnel; Molecular Structure; Occupational Exposure; Oxidative Stress; Permethrin; Pyrethrins; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2001 |
Evidence for reactive nitrogen species formation in the gingivomucosal tissue.
Topics: Animals; Blotting, Western; Enamel Organ; Immunohistochemistry; Male; Mouth Mucosa; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitro Compounds; Periodontitis; Rats; Rats, Wistar; Tyrosine | 2001 |
Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cell Survival; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Humans; Mice; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Superoxide Dismutase; Tyrosine | 2001 |
Activated macrophages migrate to the subcutaneous tumor site via the peritoneum: a novel route of cell trafficking.
Topics: Animals; Apoptosis; Ascitic Fluid; Cell Communication; Cell Movement; Cytokines; Cytotoxicity, Immunologic; Free Radicals; Macrophages; Neoplasm Regression, Spontaneous; Neoplasms; Peritoneum; Rats; Rats, Wistar; Skin Neoplasms; Tumor Cells, Cultured; Tyrosine | 2001 |
Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat.
Topics: Acetylcysteine; Animals; Blotting, Western; Carrageenan; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Erythrocytes; Free Radical Scavengers; I-kappa B Proteins; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lung; Macrophages; Male; Malondialdehyde; Neutrophils; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; P-Selectin; Peroxidase; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Free 3-nitrotyrosine causes striatal neurodegeneration in vivo.
Topics: Animals; Cell Count; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Immunohistochemistry; Mice; Motor Activity; Neurodegenerative Diseases; Neurons; Oxidopamine; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2001 |
Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.
Topics: Adenocarcinoma; Animals; Azoles; Bradykinin; Capillary Permeability; Collagenases; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Precursors; Free Radical Scavengers; Gelatinases; Guinea Pigs; Isoindoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Nitrates; Oligopeptides; Organoselenium Compounds; Protease Inhibitors; Sarcoma 180; Skin; Tyrosine; Uric Acid | 2001 |
Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Blood Vessels; Body Weight; Genotype; Hypertrophy; Immunohistochemistry; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; RNA, Messenger; Superoxides; Tyrosine | 2001 |
Circulating activated endothelial cells in systemic lupus erythematosus: further evidence for diffuse vasculopathy.
Topics: Cell Adhesion Molecules; Cohort Studies; Complement Activation; Endothelium, Vascular; Female; Humans; Immunophenotyping; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Male; Tyrosine | 2001 |
Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lysine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid; Tyrosine | 2001 |
Nitration of tyrosine residues in protein-nucleic acid complexes.
Topics: Chromatography, High Pressure Liquid; DNA; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Indicators and Reagents; Peptide Fragments; Peptide Mapping; Spectrometry, Fluorescence; Tetranitromethane; Tyrosine | 2001 |
Nitric oxide and Coxsackievirus B3 myocarditis: differential expression of inducible nitric oxide synthase in mouse heart after infection with virulent or attenuated virus.
Topics: Animals; Disease Models, Animal; Enterovirus; Guanosine Monophosphate; Heart; Immunohistochemistry; Male; Mice; Myocarditis; Myocardium; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nucleic Acid Hybridization; RNA, Viral; Tyrosine | 2001 |
Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Free Radicals; Hydrogen Peroxide; Liver; Multienzyme Complexes; Naphthols; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteins; Rats; Singlet Oxygen; Tyrosine | 2001 |
Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Glycoproteins; Mercury Poisoning, Nervous System; Methylmercury Compounds; Nerve Degeneration; Neurons; Nitrates; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2001 |
Role of nitric oxide synthase in collagen-platelet interaction: involvement of platelet nonintegrin collagen receptor nitrotyrosylation.
Topics: Blood Platelets; Blood Proteins; Collagen; Humans; In Vitro Techniques; Integrins; Kinetics; Molecular Weight; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Placenta; Platelet Aggregation; Receptors, Collagen; Recombinant Proteins; Tyrosine | 2001 |
Actin is oxidized during myocardial ischemia.
Topics: Actins; Animals; Blood Pressure; Heart; Heart Rate; Immunoblotting; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Oxidation-Reduction; Perfusion; Rats; Rats, Sprague-Dawley; Troponin T; Tyrosine; Ventricular Function, Left | 2001 |
In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation.
Topics: Annexin A5; Apoptosis; Cells, Cultured; Child, Preschool; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; In Situ Nick-End Labeling; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stromal Cells; Superoxide Dismutase; Superoxides; T-Lymphocytes; Thymus Gland; Tyrosine | 2001 |
Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Cytokines; Female; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Macrophage Inflammatory Proteins; Male; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Monokines; Nitric Oxide Synthase; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine; Up-Regulation | 2001 |
IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomyopathies; Diabetic Angiopathies; DNA; Insulin-Like Growth Factor I; Mice; Mice, Transgenic; Myocardium; Oxidative Stress; Reactive Oxygen Species; Renin-Angiotensin System; Tissue Distribution; Tumor Suppressor Protein p53; Tyrosine; Ventricular Function | 2001 |
Propofol attenuates diaphragmatic dysfunction induced by septic peritonitis in hamsters.
Topics: Animals; Cricetinae; Diaphragm; Dose-Response Relationship, Drug; Endotoxins; Immunohistochemistry; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritonitis; Propofol; Sepsis; Tyrosine | 2001 |
iNOS and nitrotyrosine expression after spinal cord injury.
Topics: Animals; Blotting, Western; Female; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Long-Evans; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae; Tyrosine | 2001 |
Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions.
Topics: Adult; Aged; Female; Humans; Immunohistochemistry; In Situ Hybridization; Male; Middle Aged; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Transcription, Genetic; Tyrosine | 2001 |
Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model.
Topics: Animals; Anterior Cruciate Ligament; Culture Media, Conditioned; Hyaluronic Acid; Immunohistochemistry; Injections, Intra-Articular; Lipopolysaccharides; Menisci, Tibial; Nitric Oxide; Organ Culture Techniques; Osteoarthritis, Knee; Rabbits; Synovial Membrane; Tyrosine | 2001 |
Long-term inhalation of high-dose nitric oxide increases intraalveolar activation of coagulation system in mice.
Topics: Administration, Inhalation; Animals; Blood Coagulation; Bronchi; Bronchoalveolar Lavage Fluid; Cell Line; Female; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitro Compounds; Proteins; Pulmonary Alveoli; Reverse Transcriptase Polymerase Chain Reaction; Thrombin; Thromboplastin; Tyrosine | 2001 |
Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration.
Topics: Amino Acid Sequence; Animals; Brain; Coenzyme A-Transferases; Endotoxins; Escherichia coli; Kidney; Lipopolysaccharides; Male; Mitochondria; Mitochondria, Heart; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2001 |
Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosa.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Biomarkers; Chronic Disease; Deoxyguanosine; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peptic Ulcer; Tyrosine | 2001 |
Protein tyrosine nitration in cytokine-activated murine macrophages. Involvement of a peroxidase/nitrite pathway rather than peroxynitrite.
Topics: Animals; Cell Line; Cytokines; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Free Radical Scavengers; Hydrogen Peroxide; Immunoblotting; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitrates; Nitric Oxide; Nitrites; Nitrogen; Oxygen; Peroxidase; Recombinant Proteins; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Zymosan | 2001 |
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis.
Topics: Animals; Coumarins; Encephalomyelitis, Autoimmune, Experimental; Enzyme Activation; Immunohistochemistry; Male; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Spinal Cord; Tyrosine | 2001 |
Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production.
Topics: Acetylcysteine; Cell Physiological Phenomena; Cell Survival; Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; Free Radicals; Glutathione; Humans; Lipid Metabolism; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrogen; Oxidative Stress; Proteasome Endopeptidase Complex; Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Tumor Cells, Cultured; Tyrosine; Ubiquitins | 2001 |
Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function.
Topics: Aging; Animals; Apoptosis; Biomarkers; Gonadotropin-Releasing Hormone; Hypothalamus; Immunohistochemistry; In Situ Nick-End Labeling; Male; Microscopy, Fluorescence; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxytocin; Rats; Rats, Inbred BN; Reproduction; Tyrosine | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis.
Topics: Animals; Cell Adhesion Molecules; Chronic Disease; Colitis; Dextran Sulfate; Immunoglobulins; Immunohistochemistry; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucoproteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2001 |
Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan.
Topics: Animals; Enzyme Inhibitors; Exudates and Transudates; Guanidines; Lipid Peroxidation; Liver; Lung; Macrophages, Peritoneal; Male; Mice; Mice, Knockout; Multiple Organ Failure; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peritonitis; Peroxidase; Poly(ADP-ribose) Polymerases; Rhodamines; Shock; Tyrosine; Zymosan | 2001 |
Myoglobin-catalyzed tyrosine nitration: no need for peroxynitrite.
Topics: Animals; Horses; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Metmyoglobin; Myocardium; Myoglobin; Nitrates; Nitrites; Oxidation-Reduction; Tyrosine | 2001 |
Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation.
Topics: Aged; Atrial Appendage; Atrial Fibrillation; Biomarkers; Blotting, Western; Chronic Disease; Creatine Kinase; Creatine Kinase, MB Form; DNA; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Female; Humans; Hydroxyl Radical; Isoenzymes; Male; Middle Aged; Myocardial Contraction; Myocardium; Myofibrils; Myosins; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Protein Isoforms; Proteins; Tyrosine | 2001 |
Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Kidney Cortex; Male; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Staining and Labeling; Superoxide Dismutase; Superoxides; Tissue Distribution; Tyrosine | 2001 |
Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4-hydroxynonenal or serum deprivation: potentiation of injury by ALS-related mutant superoxide dismutases and pro
Topics: Aldehydes; Amino Acid Substitution; Cell Death; Cell Survival; Cross-Linking Reagents; Culture Media, Serum-Free; Genes, bcl-2; Guanine; Humans; Hydrogen Peroxide; Kinetics; Lipid Peroxidation; Motor Neuron Disease; Mutagenesis, Site-Directed; Neuroblastoma; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Teratocarcinoma; Tumor Cells, Cultured; Tyrosine | 2001 |
Localization of 3-nitrotyrosine to rheumatoid and normal synovium.
Topics: Actins; Aged; Aged, 80 and over; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arthritis, Rheumatoid; Female; Humans; Immunohistochemistry; Macrophages; Male; Mice; Mice, Knockout; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Synovial Membrane; Tyrosine | 2001 |
Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats.
Topics: Acetylcysteine; Animals; Free Radical Scavengers; Gentamicins; Kidney; Male; Malondialdehyde; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Tyrosine | 2001 |
Kinetic and mechanistic studies of the reactions of nitrogen monoxide and nitrite with ferryl myoglobin.
Topics: Kinetics; Mechanics; Metmyoglobin; Nitric Oxide; Nitrites; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Tyrosine | 2001 |
Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase.
Topics: Animals; Benzamides; Enzyme Inhibitors; Immunohistochemistry; Interleukin-10; Interleukin-12; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; NAD; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tissue Extracts; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Gadolinium chloride inhibits pulmonary macrophage influx and prevents O(2)-induced pulmonary hypertension in the neonatal rat.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Cell Movement; Cells, Cultured; Dinoprost; Endothelin-1; F2-Isoprostanes; Gadolinium; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Infant, Newborn; Macrophages, Alveolar; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation.
Topics: Animals; Aorta; Blood Flow Velocity; In Vitro Techniques; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Nitrates; Rats; Rats, Wistar; Time Factors; Tyrosine; Ventricular Function, Left | 2001 |
Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Enzyme Inhibitors; Glucose; Hypoxia-Ischemia, Brain; Immunohistochemistry; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Purkinje Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Tyrosine | 2001 |
Modulation of reactive oxygen species in endothelial cells by peroxynitrite-treated lipoproteins.
Topics: Arteriosclerosis; Catalase; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Free Radical Scavengers; Humans; Lipoproteins; Lipoproteins, HDL; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2001 |
Effect of nitrite on endothelial function in isolated lung.
Topics: Animals; Blood Pressure; Capillary Permeability; Carcinogens; Dimethyl Sulfoxide; Endothelium, Vascular; Free Radical Scavengers; Lipopolysaccharides; Lung; Male; Models, Animal; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrites; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Apoptosis; Blotting, Western; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Caspase 3; Caspase 9; Caspases; Cytochrome c Group; Disease Models, Animal; Dogs; Enzyme Activation; Hemodynamics; Immunohistochemistry; In Situ Nick-End Labeling; Myocardium; Oxidative Stress; Protein Biosynthesis; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Tumor Suppressor Protein p53; Tyrosine; Ventricular Dysfunction | 2001 |
Oxidative damage is the earliest event in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Brain; Disease Progression; Female; Genotype; Guanosine; Heterozygote; Humans; Male; Middle Aged; Neurofibrillary Tangles; Neurons; Oxidative Stress; Plaque, Amyloid; Tyrosine | 2001 |
Specific electrochemical nitration of horse heart myoglobin.
Topics: Amino Acid Sequence; Animals; Apoproteins; Blotting, Western; Electrochemistry; Electrophoresis, Polyacrylamide Gel; Fourier Analysis; Horses; Hydrogen-Ion Concentration; Mass Spectrometry; Molecular Sequence Data; Myocardium; Myoglobin; Nitrogen; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Tyrosine | 2001 |
Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice.
Topics: Animals; Female; Gene Expression Regulation, Enzymologic; Genotype; Heart Ventricles; Hemodynamics; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardial Contraction; Myocardial Infarction; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger; Survival Rate; Time Factors; Tyrosine | 2001 |
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis.
Topics: Adult; Breath Tests; Cystic Fibrosis; Female; Humans; Lung Volume Measurements; Male; Oxidative Stress; Reactive Nitrogen Species; Reference Values; Tyrosine | 2001 |
Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin's lymphomas and multiple myeloma.
Topics: Adult; Aged; Cell Nucleus; Cytoplasm; Female; Humans; Immunohistochemistry; Isoenzymes; Lymphoma, B-Cell; Male; Middle Aged; Multiple Myeloma; Nitric Oxide Synthase; Tyrosine | 2001 |
Diversity of endotoxin-induced nitrotyrosine formation in macrophage-endothelium-rich organs.
Topics: Animals; Endothelium, Vascular; Immunoblotting; Immunoenzyme Techniques; Lipopolysaccharides; Liver; Lung; Macrophages; Male; Molsidomine; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Sprague-Dawley; Spleen; Superoxides; Tyrosine | 2001 |
Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model.
Topics: Animals; Ascorbic Acid; Dogs; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Hemodynamics; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Nitric Oxide Synthase; Nitroarginine; Superoxides; Tyrosine | 2001 |
Role of CD23 in astrocytes inflammatory reaction during HIV-1 related encephalitis.
Topics: AIDS Dementia Complex; Astrocytes; Brain; HIV Envelope Protein gp120; HIV-1; Humans; Interleukin-1; Neuroglia; Nitric Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Receptors, IgE; RNA, Messenger; Tyrosine | 2001 |
Induction of oxidative stress by homocyst(e)ine impairs endothelial function.
Topics: Acetylcholine; Animals; Aorta; Caspases; Cysteine; Elastin; Endothelium, Vascular; Glutathione; Homocysteine; In Vitro Techniques; Metalloendopeptidases; Niacinamide; Nitric Oxide; Nitroprusside; Oxidative Stress; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Tyrosine; Vasodilation | 2001 |
Peroxynitrite causes endothelial cell monolayer barrier dysfunction.
Topics: Actins; Animals; beta Catenin; Cell Survival; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Kinetics; Molsidomine; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Pulmonary Artery; Reactive Oxygen Species; Superoxide Dismutase; Swine; Trans-Activators; Tyrosine | 2001 |
Oxidative inactivation of nitric oxide and endothelial dysfunction in stroke-prone spontaneous hypertensive rats.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Apoptosis; Blood Pressure; Carbazoles; Carvedilol; Endothelium, Vascular; Immunohistochemistry; In Situ Nick-End Labeling; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Propanolamines; Rats; Rats, Inbred SHR; Stroke; Tyrosine | 2001 |
The effect of Escherichia coli-derived lipopolysaccharides on plasma levels of malondialdehyde and 3-nitrotyrosine.
Topics: Animals; Escherichia coli; Escherichia coli Infections; Free Radicals; Lipid Peroxidation; Lipopolysaccharides; Lipoproteins, LDL; Malondialdehyde; Oxidation-Reduction; Rats; Tyrosine | 2001 |
Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress.
Topics: Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Oxidative Stress; Reference Values; Sensitivity and Specificity; Tyrosine | 2001 |
-OONO: rebounding from nitric oxide.
Topics: Administration, Inhalation; Animals; Endothelium, Vascular; Epoprostenol; Hemoglobins; Humans; Hydroxyl Radical; Hypertension, Pulmonary; Nitrates; Nitric Oxide; Nitrogen Dioxide; Oxidation-Reduction; Pneumonia; Prostaglandin H2; Prostaglandins H; Signal Transduction; Superoxides; Tyrosine | 2001 |
Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
Topics: Administration, Inhalation; Animals; Blotting, Western; Cells, Cultured; Dioxoles; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Humans; Hypertension, Pulmonary; Lung; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pulmonary Artery; Receptor, Endothelin A; Secondary Prevention; Sheep; Superoxides; Tyrosine | 2001 |
Oxidative stress and reactive nitrogen species generation during renal ischemia.
Topics: Aldehydes; Animals; Blood Urea Nitrogen; Creatinine; Free Radicals; Glutathione; Kidney; Male; Nitrates; Oxidation-Reduction; Oxidative Stress; Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Tyrosine | 2001 |
Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis.
Topics: Adult; Aged; Arginine; Blotting, Western; Body Fluids; Case-Control Studies; Colitis, Ulcerative; Confidence Intervals; Female; Humans; Intestinal Absorption; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Statistics, Nonparametric; Tyrosine; Up-Regulation | 2001 |
Nitrotyrosine mimics phosphotyrosine binding to the SH2 domain of the src family tyrosine kinase lyn.
Topics: Amino Acid Sequence; Anion Exchange Protein 1, Erythrocyte; Binding Sites; Enzyme Activation; Humans; In Vitro Techniques; Phosphotyrosine; Recombinant Proteins; src Homology Domains; src-Family Kinases; Tyrosine | 2001 |
Combined exposure to sarin and pyridostigmine bromide increased levels of rat urinary 3-nitrotyrosine and 8-hydroxy-2'-deoxyguanosine, biomarkers of oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Calibration; Chemical Warfare Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Deoxyguanosine; Oxidative Stress; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Sarin; Tyrosine | 2001 |
Peroxynitrite formation from human myocardium after ischemia-reperfusion during open heart operation.
Topics: Adult; Aged; Cardiopulmonary Bypass; Creatine Kinase; Creatine Kinase, MB Form; Female; Heart Valve Prosthesis Implantation; Humans; Isoenzymes; Male; Malondialdehyde; Middle Aged; Myocardial Reperfusion Injury; Myocardium; Nitrates; Tyrosine | 2001 |
Acute hyperglycemia induces an oxidative stress in healthy subjects.
Topics: Adult; Biomarkers; Confounding Factors, Epidemiologic; Diabetic Angiopathies; Female; Glucose Clamp Technique; Hemodynamics; Humans; Hydrogen-Ion Concentration; Hyperglycemia; Male; Nitrates; Oxidative Stress; Tyrosine; Vasoconstriction | 2001 |
Increased tyrosine nitration of the brain in chronic renal insufficiency: reversal by antioxidant therapy and angiotensin-converting enzyme inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blotting, Western; Brain; Captopril; Kidney Failure, Chronic; Male; Pregnatrienes; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tyrosine | 2001 |
Peroxynitrite-induced tyrosine nitration and inhibition of protein kinase C.
Topics: Animals; Brain; Cysteine; Isoenzymes; Male; Neurodegenerative Diseases; Nitrates; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxidants; Oxidation-Reduction; Penicillamine; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Tissue Extracts; Tyrosine | 2001 |
Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Vessels; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Fructose; Inositol; Male; Manganese; Neural Conduction; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Superoxides; Thiobarbituric Acid Reactive Substances; Triglycerides; Tyrosine; Vasodilation; Vasodilator Agents | 2001 |
Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction.
Topics: Animals; Blotting, Northern; Blotting, Western; Collagen; Gene Expression Regulation; Heart Failure; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Contraction; Myocardial Infarction; Myosin Heavy Chains; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2001 |
Inhibition of peroxynitrite-induced nitration of tyrosine by glutathione in the presence of carbon dioxide through both radical repair and peroxynitrate formation.
Topics: Antioxidants; Carbon Dioxide; Free Radicals; Glutathione; Peroxynitrous Acid; Superoxides; Tyrosine | 2001 |
Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Coarctation; Baroreflex; Blotting, Western; Brain; Disease Models, Animal; Hypertension; Male; Myocardium; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Central Nervous System Diseases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radicals; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Interneurons; Motor Neurons; Nerve Degeneration; Neurons; Neurotoxins; Nitrates; Nitric Oxide Donors; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spinal Cord; Tyrosine | 2001 |
The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent.
Topics: Acute Disease; Animals; Antigens, Viral; Blood-Brain Barrier; Borna Disease; Borna disease virus; Brain; Brain Chemistry; Chemotaxis, Leukocyte; Encephalitis, Viral; Female; Free Radical Scavengers; Free Radicals; Gene Expression Profiling; Immunocompetence; Inflammation; Lymphocyte Count; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxynitrous Acid; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; T-Lymphocyte Subsets; Tyrosine; Uric Acid; Virus Replication | 2001 |
In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies.
Topics: Aldehydes; Cyclic N-Oxides; Deferoxamine; Female; Fluorescent Antibody Technique; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Hypoxia; Immunohistochemistry; Ischemia; Nitrogen Oxides; Oxidative Stress; Oxygen; Placenta; Pregnancy; Pregnancy Complications; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tissue Distribution; Tyrosine | 2001 |
Cyclophosphamide decreases nitrotyrosine formation and inhibits nitric oxide production by alveolar macrophages in mycoplasmosis.
Topics: Animals; Cells, Cultured; Cyclophosphamide; Disease Models, Animal; Immunosuppressive Agents; Leukocyte Count; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycoplasma; Mycoplasma Infections; Neutrophils; Nitric Oxide; Tyrosine | 2001 |
Substrate specificity of the streptococcal cysteine protease.
Topics: Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mass Spectrometry; Mutation; Streptococcus pyogenes; Substrate Specificity; Tyrosine | 2001 |
Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain Chemistry; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Fever; Homovanillic Acid; Male; Methamphetamine; Nitrates; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antibodies; Blotting, Western; Female; Humans; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2001 |
Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia.
Topics: Animals; Endotoxemia; Gas Chromatography-Mass Spectrometry; Half-Life; Immunohistochemistry; Lipopolysaccharides; Liver; Liver Cirrhosis; Luminescent Measurements; Male; Metabolic Clearance Rate; Neutrophils; Nitroso Compounds; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Serum Albumin, Bovine; Tyrosine | 2001 |
Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation.
Topics: Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Female; Immunosuppressive Agents; Interferon-gamma; Macrophages; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Pneumonia; Survival Rate; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Experimental abdominal aortic aneurysms in mice lacking expression of inducible nitric oxide synthase.
Topics: Animals; Aortic Aneurysm, Abdominal; Dilatation, Pathologic; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ovariectomy; Pancreatic Elastase; RNA, Messenger; Tyrosine | 2001 |
Inducible nitric oxide synthase expression and nuclear factor-kappaB activation in alveolar type II cells in lung injury.
Topics: Animals; Dexamethasone; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Glucocorticoids; Immunohistochemistry; Lipopolysaccharides; Male; NF-kappa B; NF-kappa B p50 Subunit; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; RNA, Messenger; Specific Pathogen-Free Organisms; Tyrosine | 2001 |
Plasma and bronchoalveolar fluid concentrations of nitric oxide and localization of nitric oxide synthesis in the lungs of horses with summer pasture-associated obstructive pulmonary disease.
Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Epithelium; Female; Horse Diseases; Horses; Immunohistochemistry; Lung Diseases, Obstructive; Male; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2001 |
Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitrates; omega-N-Methylarginine; Precipitin Tests; Proteins; Rats; Rats, Wistar; Tyrosine | 2001 |
Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial meniscectomy.
Topics: Animals; Apoptosis; Cartilage, Articular; Cells, Cultured; Chondrocytes; Gene Expression Regulation, Enzymologic; In Situ Nick-End Labeling; Menisci, Tibial; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis, Knee; Rabbits; RNA, Messenger; Tyrosine | 2001 |
Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants.
Topics: Acetates; Acetylcholine; Animals; Antioxidants; Biological Transport; Carbon Radioisotopes; Choline; Choline O-Acetyltransferase; Drug Interactions; Molsidomine; Nitrates; Oxidants; Reducing Agents; Torpedo; Tyrosine; Uric Acid | 2001 |
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation.
Topics: Animals; Brain; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Female; Heart; Hydrogen Peroxide; Immunoblotting; Liver; Mitochondria; Mitochondria, Heart; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Nitric Oxide; Oxidoreductases; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Succinate Cytochrome c Oxidoreductase; Succinate Dehydrogenase; Succinates; Superoxide Dismutase; Superoxides; Tyrosine | 2001 |
Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice.
Topics: Acetophenones; Amidines; Animals; Antioxidants; Benzylamines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Hypersensitivity; Immunoglobulin E; Immunohistochemistry; Interferon-gamma; Interleukin-4; Interleukin-5; Lung; Male; Mice; Mice, Inbred BALB C; Neutrophils; Nitric Oxide Synthase; Ovalbumin; Specific Pathogen-Free Organisms; Tyrosine | 2001 |
Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Hypertension, Renovascular; Losartan; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Artery; Renin; Spin Labels; Superoxides; Systole; Time Factors; Tyrosine | 2001 |
Tyrosine nitration in human spermatozoa: a physiological function of peroxynitrite, the reaction product of nitric oxide and superoxide.
Topics: Calcimycin; Female; Follicular Fluid; Humans; Ionophores; Male; Nitric Oxide; Peroxynitrous Acid; Phosphorylation; Proteins; Sperm Capacitation; Sperm Motility; Spermatozoa; Superoxides; Tyrosine | 2001 |
Immunotherapy of C3H/HeJ mammary adenocarcinoma with interleukin-2, mistletoe lectin or their combination. effects on tumour growth, capillary leakage and nitric oxide (NO) production.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Capillary Permeability; Female; Interleukin-2; Kidney; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Nitric Oxide; Plant Preparations; Plant Proteins; Pleural Effusion, Malignant; Recombinant Proteins; Ribosome Inactivating Proteins, Type 2; Toxins, Biological; Tumor Cells, Cultured; Tyrosine | 2001 |
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs.
Topics: Animals; Blood Gas Analysis; Blotting, Western; Disease Models, Animal; Hemodynamics; Lipopolysaccharides; Liver; Lung; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Sepsis; Swine; Tyrosine | 2001 |
Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.
Topics: Animals; Apoptosis; Encephalomyelitis, Autoimmune, Experimental; Gliosis; In Situ Nick-End Labeling; Interleukin-1; Interleukin-6; Macrophages; Malondialdehyde; Metallothionein; Mice; Mice, Inbred Strains; Mice, Knockout; Microglia; Nerve Degeneration; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Gene Deletion; Immunoenzyme Techniques; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2001 |
Antioxidants improve brain function in advanced renal failure.
Topics: Animals; Antioxidants; Brain Diseases; Humans; Kidney Failure, Chronic; Oxidative Stress; Rats; Tyrosine | 2001 |
Oxidative and nitrosative stress in acute renal ischemia.
Topics: Animals; Azoles; Blotting, Western; Cell Line; Cyclic N-Oxides; DNA Damage; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Ischemia; Isoindoles; Kidney; Lipid Peroxidation; Lysine; Macrophages; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Organoselenium Compounds; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spin Labels; Superoxide Dismutase; Tyrosine | 2001 |
Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences.
Topics: Blotting, Western; Electrophoresis, Polyacrylamide Gel; Glioblastoma; Glioma; Humans; Immunohistochemistry; Oligonucleotides; Peroxynitrous Acid; Protein Processing, Post-Translational; Recombinant Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrosine | 2001 |
Inactivation of glutathione S-transferases by nitric oxide-derived oxidants: exploring a role for tyrosine nitration.
Topics: Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione Transferase; Hydrogen Peroxide; Liver; Male; Mice; Nitrates; Nitric Oxide; Oxidants; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reducing Agents; S-Nitrosoglutathione; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2001 |
Detection of inducible nitric oxide synthase- and nitrotyrosine-positive cells in the lesions of pericarditis induced by porcine enterovirus serotype 3 infection.
Topics: Animals; Animals, Newborn; Enterovirus Infections; Enteroviruses, Porcine; Immunohistochemistry; Microscopy, Electron; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pericarditis; Pericardium; Swine; Swine Diseases; Tyrosine | 2001 |
Expression of inducible nitric oxide synthase and nitrotyrosine during the evolution of experimental pulmonary tuberculosis.
Topics: Animals; Cell Count; Disease Models, Animal; Immunoenzyme Techniques; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tuberculosis, Pulmonary; Tyrosine | 2001 |
Nitric oxide targets bronchiolar epithelial cells in murine cytomegalovirus-associated disease in lungs that are free of the virus.
Topics: Animals; Antibodies; Bronchi; CD3 Complex; Herpesviridae Infections; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Muromegalovirus; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pneumonia, Viral; Respiratory Mucosa; Tyrosine | 2001 |
A novel selectin blocker alleviates oxidative stress of lung reperfusion injury.
Topics: Animals; Deoxyguanosine; Free Radical Scavengers; Ischemia; Lung; Male; Neutrophil Infiltration; Oxidative Stress; Peroxynitrous Acid; Pulmonary Circulation; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Reperfusion Injury; Selectins; Tyrosine | 2001 |
SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death.
Topics: Animals; Astrocytes; Catalase; Cell Death; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Mice; Molsidomine; Neurons; Neurotoxins; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2001 |
Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.
Topics: Animals; Blood Vessels; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Hyperglycemia; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2001 |
Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: effects of L-NAME on symptom progression.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Disease Models, Animal; Enzyme Inhibitors; Female; Huntington Disease; Immunohistochemistry; Male; Mice; Mice, Transgenic; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Tyrosine | 2001 |
Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability.
Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Biological Availability; Blood Platelets; Case-Control Studies; Chronic Disease; Cyclic GMP; Free Radical Scavengers; Glutathione; Humans; Male; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Platelet Aggregation; Smoking; Time Factors; Tyrosine | 2001 |
Synthesis of ascorbate and urate in the ovary of water buffalo.
Topics: Animals; Antioxidants; Ascorbic Acid; Buffaloes; Caspase 3; Caspases; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Follicular Fluid; Granulosa Cells; L-Gulonolactone Oxidase; Microsomes; Ovary; Rats; Sugar Alcohol Dehydrogenases; Tyrosine; Uric Acid | 2001 |
Lack of influence of dietary nitrate/nitrite on plasma nitrotyrosine levels measured using a competitive inhibition of binding ELISA assay.
Topics: Adult; Binding, Competitive; Blood Proteins; Diet; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitrates; Nitrites; Sensitivity and Specificity; Tyrosine | 2001 |
Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells.
Topics: Animals; Antioxidants; Ascorbic Acid; Carrier Proteins; Cell Line; Diabetes Mellitus; Dose-Response Relationship, Drug; Glutathione; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Transport Proteins; Methylene Blue; Mice; Mice, Inbred ICR; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pigment Epithelium of Eye; Protein Synthesis Inhibitors; Taurine; Time Factors; Tyrosine | 2001 |
Influenza A virus infection of mice induces nuclear accumulation of the tumorsuppressor protein p53 in the lung.
Topics: Animals; Apoptosis; Cell Nucleus; Cells; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Female; In Situ Nick-End Labeling; Inflammation; Influenza A virus; Lung; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Tumor Suppressor Protein p53; Tyrosine | 2001 |
Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
Topics: Animals; Apoptosis; beta-Galactosidase; Bone Marrow; Bystander Effect; Chemotaxis, Leukocyte; Dose-Response Relationship, Radiation; Enzyme Induction; Gamma Rays; Genes, p53; Genetic Predisposition to Disease; Genotype; Inflammation; Lysosomes; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Knockout; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiation Injuries, Experimental; Radiation Tolerance; Respiratory Burst; Species Specificity; Spleen; Tumor Suppressor Protein p53; Tyrosine; Whole-Body Irradiation | 2001 |
Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; China; Chronic Disease; Codon; Codon, Nonsense; CpG Islands; Cyclooxygenase 2; DNA Mutational Analysis; DNA, Neoplasm; Esophageal Neoplasms; Esophagitis; Europe; Exons; Female; Frameshift Mutation; Genes, p53; Humans; Incidence; Iran; Isoenzymes; Male; Membrane Proteins; Middle Aged; Mutation; Neoplasm Proteins; Nitric Oxide; Point Mutation; Prostaglandin-Endoperoxide Synthases; Risk Factors; Sequence Analysis, DNA; Tyrosine | 2001 |
Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation.
Topics: Animals; Biopterins; Blood Platelets; Coronary Thrombosis; Cyclic GMP; Dogs; Enzyme Inhibitors; Hemodynamics; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; P-Selectin; Platelet Aggregation; Superoxides; Tyrosine | 2001 |
Formation of nitrotyrosine by methylene blue photosensitized oxidation of tyrosine in the presence of nitrite.
Topics: Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Inflammation; Methylene Blue; Nitrites; Oxidation-Reduction; Photochemistry; Singlet Oxygen; Tyrosine | 2001 |
Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase.
Topics: Animals; Catalysis; Coenzyme A-Transferases; Diabetes Mellitus, Experimental; Energy Metabolism; Enzyme Activation; Kidney; Lipid Peroxidation; Male; Mitochondria; Myocardium; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Tyrosine | 2001 |
Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex.
Topics: Adrenal Cortex; Animals; Arabidopsis Proteins; Blotting, Western; Female; HSP90 Heat-Shock Proteins; Immunohistochemistry; Macaca mulatta; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Plant Proteins; Pregnancy; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sheep; Steroid 17-alpha-Hydroxylase; Tyrosine; Zona Fasciculata; Zona Glomerulosa | 2001 |
Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.
Topics: Animals; Arginine; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Drug Interactions; Endotoxins; Ethanol; Humans; Inflammation; Isoenzymes; Lipid Peroxidation; Liver; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Male; Membrane Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage.
Topics: Aging; Collagen Type I; Humans; Nitrates; Nitrogen; Tyrosine | 2001 |
Cargo delivery kinetics of cell-penetrating peptides.
Topics: Amino Acid Sequence; Carrier Proteins; Cell Membrane Permeability; Cell-Penetrating Peptides; Cystine; Drug Carriers; Fluorescence; Galanin; Humans; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Peptides; Recombinant Fusion Proteins; Tumor Cells, Cultured; Tyrosine; Wasp Venoms | 2001 |
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents.
Topics: Aging; Animals; Behavior, Animal; DNA, Mitochondrial; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hippocampus; Learning Disabilities; Male; Neurons; Nucleic Acids; Oxidation-Reduction; Oxidative Stress; Rats; RNA, Messenger; Space Perception; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Selective nitration of histone tyrosine residues in vivo in mutatect tumors.
Topics: Animals; Blotting, Western; Fibrosarcoma; Histones; Interleukin-2; Interleukin-8; Mice; Neutrophils; Nitric Oxide; Nitrites; Nucleosomes; Tumor Cells, Cultured; Tyrosine | 2002 |
Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Blotting, Western; Chromatography, High Pressure Liquid; Fluorescent Antibody Technique; Haptens; Immunoassay; Immunohistochemistry; Liver; Male; Mice; Rats; Rats, Inbred F344; Tissue Distribution; Tyrosine; Zymosan | 2001 |
Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritis.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Immunohistochemistry; Isoantibodies; Kidney Glomerulus; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation; Proteinuria; Rats; Tyrosine | 2001 |
Systemic biochemical effects of inhaled NO in rats: increased expressions of NOS III, nitrotyrosine-, and phosphotyrosine-immunoreactive proteins in liver and kidney tissues.
Topics: Administration, Inhalation; Animals; Blood Pressure; Blotting, Western; Kidney; Liver; Nitric Oxide; Nitric Oxide Synthase; Phosphotyrosine; Proteins; Rats; Rats, Sprague-Dawley; Tyrosine | 2001 |
Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis.
Topics: Animals; Body Weight; Colitis; Colon; Cytokines; Enzyme Activation; Free Radical Scavengers; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Manganese; Organometallic Compounds; P-Selectin; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Survival Analysis; Time Factors; Tyrosine | 2001 |
Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions.
Topics: Biopsy; Humans; Immunoenzyme Techniques; Leprosy, Borderline; Leprosy, Tuberculoid; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Skin; Tyrosine | 2001 |
(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments.
Topics: Antioxidants; Catechin; Dimerization; In Vitro Techniques; Liposomes; Nitrates; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2001 |
Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells.
Topics: Cell Death; Cytokines; Drug Combinations; Guanidines; Humans; Immunohistochemistry; In Vitro Techniques; Interferon-gamma; Interleukin-1; Islets of Langerhans; Peroxynitrous Acid; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose.
Topics: Adjuvants, Immunologic; Animals; Astrocytes; Brain; Brain Ischemia; Cell Death; Cytokines; Dehydroepiandrosterone; Enzyme Inhibitors; Free Radical Scavengers; Glioma; Glucose; Herbicides; Humans; Interferon-gamma; Lipopolysaccharides; Metalloporphyrins; Molsidomine; Neurons; Nitric Oxide; Oxidative Stress; Paraquat; Peroxynitrous Acid; Superoxide Dismutase; Tumor Cells, Cultured; Tyrosine | 2001 |
Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy.
Topics: Aconitate Hydratase; Animals; Brain Diseases, Metabolic; Cerebellum; Down-Regulation; Energy Metabolism; Glutamate Dehydrogenase; Humans; Immunoblotting; Ketoglutarate Dehydrogenase Complex; Mice; Mitochondria; Mitochondrial Diseases; Nitric Oxide; Oxidative Stress; Subcellular Fractions; Supranuclear Palsy, Progressive; Tyrosine | 2001 |
Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Calcium; Calcium Signaling; Cyclic AMP; Cyclic GMP; Humans; In Vitro Techniques; Kinetics; Linoleic Acid; Linoleic Acids; Nitro Compounds; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Thrombin; Tyrosine; Vasodilator Agents | 2002 |
Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration.
Topics: Animals; Biological Transport; Cell Degranulation; Endothelium, Vascular; Extracellular Matrix Proteins; Glycosaminoglycans; Humans; Mice; Mice, Inbred C57BL; Neutrophils; Nitrogen Dioxide; Peroxidase; Rabbits; Rats; Tyrosine | 2001 |
Repetitive myocardial stunning in pigs is associated with an increased formation of reactive nitrogen species.
Topics: Animals; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Swine; Tyrosine | 2002 |
The protective role of nitric oxide in a neurotoxicant-induced demyelinating model.
Topics: Animals; Apoptosis; Cell Movement; Corpus Callosum; Cuprizone; Demyelinating Diseases; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Microscopy, Fluorescence; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; Tyrosine | 2002 |
High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cel
Topics: Aorta; Apoptosis; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; DNA Fragmentation; Endothelium, Vascular; Glucose; Humans; Nitrates; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Superoxides; Tyrosine | 2002 |
Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Experimental; Arthritis, Rheumatoid; Arthrography; Collagen; Collagen Type XI; Disease Models, Animal; Interleukin-1; Joints; Male; Manganese; Molecular Weight; Organometallic Compounds; Proteins; Rats; Rats, Inbred Lew; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Weight Gain | 2001 |
Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage.
Topics: Adrenal Glands; Adrenomedullin; Angiotensin II; Animals; Blood Pressure; Cardiovascular Diseases; Coronary Vessels; Female; Genotype; Lung; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADH, NADPH Oxidoreductases; NADPH Oxidase 2; NADPH Oxidases; Peptide Fragments; Peptides; Phosphoproteins; Proteins; Reactive Oxygen Species; Sodium, Dietary; Time Factors; Tyrosine | 2002 |
Expression of caspase-3 and -9 relevant to cartilage destruction and chondrocyte apoptosis in human osteoarthritic cartilage.
Topics: Aged; Aged, 80 and over; Apoptosis; Cartilage, Articular; Caspase 3; Caspase 9; Caspases; Chondrocytes; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Microscopy, Electron; Middle Aged; Osteoarthritis; Tyrosine | 2001 |
Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tandem mass
Topics: Artifacts; Gas Chromatography-Mass Spectrometry; Humans; Male; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2002 |
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Female; Hydrogen Peroxide; Isoquinolines; Kidney; Lipid Peroxidation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Proteinuria; Quinapril; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Superoxides; Tetrahydroisoquinolines; Tetrazoles; Tyrosine | 2002 |
Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.
Topics: Adenosine Triphosphate; Apoptosis; Cell Death; Cysteine Proteinase Inhibitors; Dopamine; Electron Transport Complex I; Humans; Mitochondria; Molsidomine; NADH, NADPH Oxidoreductases; Nitric Oxide Donors; Oligopeptides; Peroxynitrous Acid; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 2002 |
Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex.
Topics: Animals; Blotting, Western; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Glucose; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2002 |
The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock.
Topics: Animals; Enzyme Inhibitors; Gene Expression Regulation; Heat-Shock Proteins; Hemodynamics; Liver; Lysine; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine Carbamoyltransferase; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Time Factors; Tyrosine | 2002 |
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cattle; Nerve Tissue Proteins; Nitric Oxide; Oxidation-Reduction; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxide Dismutase; Synucleins; Tyrosine | 2002 |
The effects of peroxynitrite on erythrocytes.
Topics: Alleles; Animals; Chromatography, High Pressure Liquid; Enzyme Induction; Erythrocytes; Escherichia coli; Escherichia coli Infections; Glutathione Peroxidase; Oxidative Stress; Peroxynitrous Acid; Rats; Sodium-Potassium-Exchanging ATPase; Spectrophotometry; Tyrosine | 2001 |
Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency.
Topics: alpha-Tocopherol; Animals; Antioxidants; Arginine; Creatinine; Endothelium, Vascular; Kidney Failure, Chronic; Male; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine | 2002 |
Oxidative stress in bacterial meningitis in humans.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aldehydes; Allantoin; Ascorbic Acid; Brain; Cysteine Proteinase Inhibitors; Female; Free Radical Scavengers; Glasgow Outcome Scale; Humans; Immunohistochemistry; Male; Meningitis, Bacterial; Middle Aged; Neurons; Oxidative Stress; Reactive Nitrogen Species; Statistics as Topic; Treatment Outcome; Tyrosine; Uric Acid | 2002 |
Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain.
Topics: Animals; Brain; Brain Infarction; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Peroxynitrous Acid; Reperfusion Injury; Time Factors; Tyrosine | 2002 |
Catalase catalyzes nitrotyrosine formation from sodium azide and hydrogen peroxide.
Topics: Animals; Catalase; Catalysis; Cattle; Hydrogen Peroxide; Hydrogen-Ion Concentration; Luminescent Measurements; Nitrates; Nitrites; Serum Albumin, Bovine; Sodium Azide; Time Factors; Tyrosine | 2001 |
Thioredoxin and protein nitrotyrosine in bone marrow supernatant from patients with human immunodeficiency virus infection.
Topics: Adult; Blood Proteins; Bone Marrow; Case-Control Studies; Female; HIV Infections; Humans; Male; Middle Aged; Proteins; Thioredoxins; Tyrosine | 2002 |
Protein denitration/modification by Escherichia coli nitrate reductase and mammalian cytochrome P-450 reductase.
Topics: Animals; Escherichia coli; Histones; Models, Chemical; NADP; NADPH-Ferrihemoprotein Reductase; Nitrate Reductase; Nitrate Reductases; Nitrates; Peroxynitrous Acid; Tyrosine | 2002 |
Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar typhimurium.
Topics: Animals; Germ-Free Life; Immunoenzyme Techniques; Intestines; Liver; Lung; Lymph Nodes; Mesentery; Microscopy, Electron; Nitric Oxide; Phagocytosis; Salmonella Infections, Animal; Salmonella typhimurium; Swine; Swine, Miniature; Tyrosine; Virulence | 2001 |
Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles.
Topics: Adult; Aged; Antigens, CD; Electron Transport Complex IV; Female; Humans; Immunoblotting; Immunohistochemistry; Infant; Lysosomal Membrane Proteins; Male; Membrane Glycoproteins; Middle Aged; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeletal; Myositis, Inclusion Body; Nitric Oxide; Oxidative Stress; Superoxide Dismutase; tau Proteins; Tyrosine; Ubiquitin; Vacuoles | 2002 |
Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Chemokines; Disease Susceptibility; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ozone; Pneumonia; Proteins; Pulmonary Edema; Tyrosine | 2002 |
Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium.
Topics: Aged; Arteries; Biopsy; Cardiac Output, Low; Cells, Cultured; Chronic Disease; Cyclooxygenase 2; Endothelium, Vascular; Fluorescent Antibody Technique; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Prostaglandin-Endoperoxide Synthases; Reference Values; Reproducibility of Results; Tyrosine; Veins | 2002 |
3-Nitrotyrosine butyl ester: a novel derivative to assess tyrosine nitration in rat plasma by liquid chromatography-tandem mass spectrometry detection.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Nitro Compounds; Rats; Tyrosine | 2002 |
Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury.
Topics: Animals; Cells, Cultured; Cytokines; Enzyme Inhibitors; Ischemia; Kidney Glomerulus; Kidney Tubules; Kidney Tubules, Proximal; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury; Thiourea; Tyrosine | 2002 |
Evidence of oxidative stress in human corneal diseases.
Topics: Cornea; Corneal Diseases; Endothelium; Epithelium; Fuchs' Endothelial Dystrophy; Humans; Keratoconus; Lipid Peroxidation; Malondialdehyde; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2002 |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke.
Topics: Animals; Apolipoproteins B; Chelating Agents; Free Radical Scavengers; Lipoproteins, LDL; Male; Peroxynitrous Acid; Rabbits; Reactive Oxygen Species; Tobacco Smoke Pollution; Tyrosine | 2002 |
Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness.
Topics: Acetylcholine; Animals; Bronchi; Bronchial Hyperreactivity; Inflammation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molsidomine; Peroxynitrous Acid; Trachea; Tyrosine | 2002 |
Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues.
Topics: Animals; Aorta; Arteriosclerosis; Cardiovascular System; Disease Progression; DNA Damage; DNA, Mitochondrial; Hypercholesterolemia; Inhalation Exposure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Myocardium; Oxidative Stress; Risk Factors; Superoxide Dismutase; Tobacco Smoke Pollution; Tyrosine | 2002 |
Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase.
Topics: Animals; Arginine; Blood Pressure; Gene Expression Regulation, Enzymologic; Glutathione Synthase; Hypertension; Immunoenzyme Techniques; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
Ebselen suppresses late airway responses and airway inflammation in guinea pigs.
Topics: Airway Resistance; Animals; Antineoplastic Agents, Alkylating; Antioxidants; Area Under Curve; Asthma; Azoles; Bronchitis; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Female; Guinea Pigs; Hydrogen Peroxide; Immunoenzyme Techniques; Isoindoles; Lung; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organoselenium Compounds; Ovalbumin; Peptide Fragments; Rabbits; Reactive Nitrogen Species; Reactive Oxygen Species; Respiratory Function Tests; Respiratory Hypersensitivity; Superoxides; Tyrosine | 2002 |
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.
Topics: Animals; Biopterins; Brain; Calcium; Calmodulin; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Flavin-Adenine Dinucleotide; Male; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Rats; Rats, Inbred Lew; RNA, Messenger; Subcellular Fractions; Tyrosine | 2002 |
Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cytokines; HSP70 Heat-Shock Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Models, Biological; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Signal Transduction; Transcription Factor AP-1; Tyrosine | 2002 |
A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species.
Topics: Animals; Candidiasis; Hydrogen Peroxide; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrites; Nitrogen Dioxide; Oxidation-Reduction; Peroxidase; Reactive Nitrogen Species; Tyrosine | 2002 |
Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver.
Topics: Adenocarcinoma; Aged; Apoptosis; Cell Division; Colorectal Neoplasms; Female; Humans; Immunoenzyme Techniques; Liver Neoplasms; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Tyrosine | 2002 |
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Bacterial Agents; Astrocytes; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Minocycline; NADPH Oxidases; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parkinsonian Disorders; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase; Up-Regulation | 2002 |
Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid cultures.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Biomarkers; Brain Chemistry; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Free Radicals; Glial Fibrillary Acidic Protein; Image Processing, Computer-Assisted; Immunohistochemistry; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitro Compounds; Oxidative Stress; Pregnancy; Propionates; Rats; Rats, Inbred Lew; Rats, Wistar; Species Specificity; Tyrosine | 2002 |
Age-related changes in the distribution of nitrotyrosine in the cerebral cortex and hippocampus of rats.
Topics: Aging; Animals; Cerebral Cortex; Hippocampus; Image Processing, Computer-Assisted; Interneurons; Oxidative Stress; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat.
Topics: Actins; Animals; Apoptosis; Coronary Circulation; Gene Expression Regulation, Enzymologic; Glucose; Glutathione; Heart; Hyperglycemia; In Vitro Techniques; Male; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Perfusion; Pressure; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Transcription, Genetic; Tyrosine | 2002 |
Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and tissue injury.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Dinoprostone; Female; Interferon-gamma; Lipopolysaccharides; Lung; Macrophages, Alveolar; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants, Photochemical; Ozone; Peroxynitrous Acid; Pneumonia; Superoxides; Tyrosine | 2002 |
Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes.
Topics: Ammonia; Animals; Astrocytes; Cells, Cultured; Dizocilpine Maleate; Drug Synergism; Glutamate-Ammonia Ligase; Glyceraldehyde-3-Phosphate Dehydrogenases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Neurological; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2002 |
Methodological considerations on the detection of 3-nitrotyrosine in the cardiovascular system.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Mass Spectrometry; Myocardium; Reactive Nitrogen Species; Sensitivity and Specificity; Tyrosine | 2002 |
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.
Topics: Aged; alpha-Synuclein; Brain; Cell Nucleus; Female; Humans; Inclusion Bodies; Lewy Bodies; Lewy Body Disease; Male; Middle Aged; Nerve Tissue Proteins; Neurites; Neuroglia; Neurons; Nitrates; Oxidative Stress; Striatonigral Degeneration; Synucleins; Tyrosine | 2002 |
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Endothelium, Vascular; Glucose; Guanidines; Hyperglycemia; Immunohistochemistry; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Retina; Streptozocin; Tyrosine | 2002 |
Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling.
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Enzyme Activation; Female; Humans; Lipid Peroxidation; Male; Middle Aged; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species; Superoxides; Thiobarbituric Acid Reactive Substances; Tyrosine | 2002 |
Role of superoxide anion in regulating pressor and vascular hypertrophic response to angiotensin II.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Blood Vessels; Gene Expression; Humans; Hypertrophy; Immunohistochemistry; Luminescent Measurements; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidases; Oxidative Stress; Superoxide Dismutase; Superoxides; Tyrosine | 2002 |
Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury.
Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Heart; Heart Rate; Incidence; Lipid Peroxidation; Myocardial Reperfusion Injury; Myocardium; Protective Agents; Rats; Reperfusion Injury; Tachycardia; Tyrosine; Ventricular Fibrillation | 2002 |
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides.
Topics: alpha 1-Antitrypsin; Anserine; Antioxidants; Carnosine; Chromatography, High Pressure Liquid; Electrophoresis, Agar Gel; Enzyme Activation; Humans; Lipoproteins, LDL; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2002 |
Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide.
Topics: Acetylcysteine; Administration, Inhalation; Animals; Female; Free Radical Scavengers; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Reactive Oxygen Species; Tyrosine; Vasodilation | 2002 |
alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Body Weight; Colitis; Colon; Cyclic N-Oxides; Dextran Sulfate; Female; Immunohistochemistry; Inflammation; Interferon-gamma; Mice; Mice, Inbred BALB C; Neutrophils; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spin Labels; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2002 |
Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cytokines; Disease Models, Animal; Erythrocytes; Intercellular Adhesion Molecule-1; Male; P-Selectin; Pleurisy; Poly(ADP-ribose) Polymerases; Pyrazoles; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sulfonamides; Tyrosine | 2002 |
Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins.
Topics: Aldehydes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dose-Response Relationship, Drug; Hydrogen Peroxide; Linoleic Acid; Melanins; Nitrogen; Oxygen; Peroxynitrous Acid; Tyrosine | 2000 |
Inducible nitric oxide synthase and nitrotyrosine in listeric encephalitis: a cross-species study in ruminants.
Topics: Animals; Brain; Cattle; Cattle Diseases; Colony Count, Microbial; Encephalitis; Goat Diseases; Goats; Immunohistochemistry; Listeria monocytogenes; Listeriosis; Macrophage Activation; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Retrospective Studies; Ruminants; Sheep; Sheep Diseases; Species Specificity; Tyrosine | 2002 |
Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Encephalitis; Hypothermia, Induced; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Male; Microglia; Monocytes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Stroke; Tyrosine | 2002 |
Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy.
Topics: Aging; Amidines; Animals; Animals, Newborn; Apoptosis; Benzylamines; Cell Count; Crosses, Genetic; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteins; Retina; Retinal Diseases; Retinal Vein Occlusion; Tyrosine | 2002 |
Whence nitrotyrosine?
Topics: Animals; Humans; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2002 |
Myeloperoxidase produces nitrating oxidants in vivo.
Topics: Animals; Klebsiella Infections; Klebsiella pneumoniae; Mice; Peritonitis; Peroxidase; Reactive Nitrogen Species; Tyrosine | 2002 |
Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein.
Topics: Amylases; Animals; Ceruletide; DNA-Binding Proteins; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Lipase; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mortality; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; P-Selectin; Pancreatitis; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Tyrosine | 2002 |
A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver.
Topics: Amidines; Animals; Aspartate Aminotransferases; Enzyme Inhibitors; Female; Heterocyclic Compounds, 2-Ring; Hot Temperature; Ischemia; L-Lactate Dehydrogenase; Liver; Liver Circulation; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Reperfusion Injury; Survival Analysis; Swine; Thrombosis; Tissue Distribution; Tyrosine | 2002 |
The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin.
Topics: Animals; Biochemistry; Biomarkers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Hair; Humans; Melanins; Mice; Mice, Inbred C57BL; Models, Chemical; Stereoisomerism; Thiazines; Time Factors; Tyrosine | 2002 |
Differential modulation of host macrophage function by AK-5 tumor is dependent on the site of tumor transplantation.
Topics: Animals; Antigens, Neoplasm; Coculture Techniques; Cytokines; Macrophages; Neoplasm Transplantation; Neoplasms, Experimental; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Cells, Cultured; Tyrosine | 2002 |
Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation.
Topics: Animals; Antioxidants; Aorta; Butylated Hydroxytoluene; Calcium; Calcium-Transporting ATPases; Culture Techniques; Dose-Response Relationship, Drug; Humans; Hypercholesterolemia; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Rabbits; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Vasodilation; Vasodilator Agents | 2002 |
Temporal and segmental distribution of constitutive and inducible nitric oxide synthases after traumatic spinal cord injury: effect of aminoguanidine treatment.
Topics: Animals; Enzyme Inhibitors; Female; Guanidines; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tyrosine | 2002 |
Nitrotyrasacutuminine from Menispermum dauricum.
Topics: Alkaloids; Circular Dichroism; Medicine, Chinese Traditional; Menispermaceae; Molecular Conformation; Molecular Structure; Morphine Derivatives; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Spectrophotometry, Infrared; Tyrosine | 2002 |
Lecithin-cholesterol acyltransferase activity during maturation of human preovulatory follicles with different concentrations of ascorbate, alpha-tocopherol and nitrotyrosine.
Topics: alpha-Tocopherol; Ascorbic Acid; Cells, Cultured; Estradiol; Female; Follicular Fluid; Humans; Ovarian Follicle; Ovulation; Phosphatidylcholine-Sterol O-Acyltransferase; Progesterone; Titrimetry; Tyrosine | 2002 |
Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase.
Topics: Animals; Asbestos, Crocidolite; Asbestosis; Body Weight; Bronchoalveolar Lavage Fluid; Cell Count; Cricetinae; Disease Models, Animal; Inhalation Exposure; Intubation, Intratracheal; Lung; Mesocricetus; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Peroxidase; Rats; RNA, Messenger; Species Specificity; Thiobarbituric Acid Reactive Substances; Tyrosine | 2002 |
Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modification.
Topics: Animals; Dietary Carbohydrates; Dietary Fats; Female; Hypertension; Nitric Oxide; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Time Factors; Tyrosine | 2002 |
Nitration of cytoskeletal proteins in the chicken embryo chorioallantoic membrane.
Topics: Actins; Allantois; Animals; Blotting, Western; Chick Embryo; Chorion; Cytoskeletal Proteins; Eosinophil Peroxidase; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidases; Peroxynitrous Acid; Tissue Extracts; Tubulin; Tyrosine; X-Rays | 2002 |
NMDA receptor stimulation induces temporary alpha-tubulin degradation signaled by nitric oxide-mediated tyrosine nitration in the nervous system of Sepia officinalis.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Immunohistochemistry; Mollusca; Nitric Oxide; Nitroarginine; Nitrogen; Optic Lobe, Nonmammalian; Precipitin Tests; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Time Factors; Tubulin; Tyrosine | 2002 |
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aging; Animals; Arginine; Arterioles; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Coronary Vessels; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Immunohistochemistry; In Vitro Techniques; Male; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vasodilation; Xanthine Oxidase | 2002 |
Determination of nitrotyrosine by HPLC-ECD and its application.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Sensitivity and Specificity; Tyrosine | 2002 |
Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation.
Topics: Animals; Carboxypeptidases; Cell Adhesion Molecules; Cell Differentiation; Cells, Cultured; Hydrogen-Ion Concentration; Morphogenesis; Muscle Development; Phosphorylation; Protein Processing, Post-Translational; Rats; Tubulin; Tyrosine | 2002 |
[Free radical in Alzheimer's disease].
Topics: Aged; alpha-Tocopherol; Alzheimer Disease; Brain; Free Radicals; Glutathione; Humans; Middle Aged; Oxidative Stress; Tyrosine | 2002 |
Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoles; Biomarkers; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Fibroblasts; Genes, src; Glutathione; Isoindoles; Kinetics; Mitochondria; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Organoselenium Compounds; Rats; S-Nitrosoglutathione; Spermine; Tyrosine | 2002 |
Nitration/S-nitrosation of proteins by peroxynitrite-treatment and subsequent modification by glutathione S-transferase and glutathione peroxidase.
Topics: Animals; Blotting, Western; Cattle; Cysteine; Electrophoresis, Polyacrylamide Gel; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hemoglobins; Histones; Horses; In Vitro Techniques; Mice; Nitrosation; Oxidative Stress; Peroxynitrous Acid; S-Nitrosothiols; Tyrosine | 2002 |
Cytotoxicity by nitrite inhalants is not related to peroxynitrite formation.
Topics: Administration, Inhalation; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Macrophages; Mice; Mitochondria; Nitrites; Oxidants; Oxygen Consumption; Peroxynitrous Acid; Tyrosine | 2002 |
Nitric oxide in the development of obliterative bronchiolitis in a heterotopic pig model.
Topics: Animals; Bronchi; Bronchiolitis Obliterans; Cell Division; Disease Models, Animal; Fibroblasts; Lung Transplantation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Respiratory Mucosa; Superoxide Dismutase; Swine; Tyrosine | 2002 |
Protein tyrosine nitration and peroxynitrite.
Topics: Animals; Cytochrome c Group; Mice; Nitric Oxide; Peroxynitrous Acid; Proteins; Superoxides; Tyrosine | 2002 |
Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis.
Topics: Animals; Autoimmune Diseases; Cytokines; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Glucuronidase; Immunoenzyme Techniques; Immunophenotyping; Macrophage Activation; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Retina; Retinitis; Tyrosine; Uveitis | 2002 |
Cyclic guanosine 5' monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclic GMP; Embryo, Mammalian; Free Radical Scavengers; Growth Substances; Immunohistochemistry; Motor Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Spinal Cord; Tyrosine | 2002 |
Evidence that light modulates protein nitration in rat retina.
Topics: Albumins; Animals; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Immunohistochemistry; Light; Male; Mass Spectrometry; Nitrogen; Rats; Rats, Sprague-Dawley; Retina; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetranitromethane; Tyrosine | 2002 |
Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity.
Topics: Amino Acid Sequence; Animals; Cell Line; Humans; Mice; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Conformation; Rats; Recombinant Proteins; Sepsis; Spodoptera; Transfection; Tyrosine | 2002 |
Protein nitration is predominantly mediated by a peroxynitrite-dependent pathway in cultured human leucocytes.
Topics: Aniline Compounds; Cells, Cultured; Extracellular Space; Humans; Leukocytes; Metalloporphyrins; Nitrates; Peroxidase; Peroxynitrous Acid; Proteins; Spermine; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cells.
Topics: Animals; Cell Differentiation; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Kinetics; Methamphetamine; Nerve Growth Factor; Neurotoxins; PC12 Cells; Peroxynitrous Acid; Pheochromocytoma; Rats; Time Factors; Tyrosine | 2002 |
The protective role of L-carnitine against neurotoxicity evoked by drug of abuse, methamphetamine, could be related to mitochondrial dysfunction.
Topics: Animals; Brain; Carnitine; Cell Survival; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Neurotoxins; PC12 Cells; Pheochromocytoma; Rats; Substance-Related Disorders; Tyrosine | 2002 |
Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries.
Topics: Animals; Capillaries; Chimera; Endothelium, Vascular; Giant Cell Arteritis; Humans; Macrophages; Mice; Mice, Inbred NOD; Mice, SCID; Neovascularization, Physiologic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reactive Nitrogen Species; Stress, Physiological; Tunica Media; Tyrosine | 2002 |
Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation.
Topics: Animals; Blotting, Western; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Hyperhomocysteinemia; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Tyrosine; Vasodilation | 2002 |
Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo.
Topics: Animals; Cardiotonic Agents; Immunohistochemistry; Intercellular Adhesion Molecule-1; Male; Manganese; Molecular Mimicry; Myocardial Ischemia; Myocardial Reperfusion Injury; Organometallic Compounds; P-Selectin; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine | 2002 |
Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure.
Topics: ADAM Proteins; ADAM12 Protein; Adult; Cardiac Output, Low; Cell Count; Connexin 43; Endocardium; Endopeptidases; Endothelium, Vascular; Humans; Integrin beta1; Membrane Proteins; Metalloendopeptidases; Middle Aged; Myocardium; Nitrates; Nitrites; Oxidative Stress; Protease Inhibitors; Reactive Oxygen Species; Tyrosine | 2002 |
Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Immunohistochemistry; Lipid Peroxides; Luminescent Measurements; Lung; Macrophages, Alveolar; Male; Nitrates; Nitric Oxide; Nitrites; Pulmonary Alveoli; Rats; Rats, Inbred F344; Reactive Oxygen Species; Silicon Dioxide; Superoxide Dismutase; Time Factors; Tyrosine; Zymosan | 2002 |
Inducible nitric oxide synthase in the tuberculous human lung.
Topics: Animals; Humans; Immunohistochemistry; In Vitro Techniques; Lung; Macrophages, Alveolar; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tuberculosis, Pulmonary; Tyrosine | 2002 |
Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis.
Topics: Epithelium; Humans; Immunohistochemistry; Lung; Lymphocytes; Macrophages; Macrophages, Alveolar; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Expression of inducible and endothelial nitric oxide synthases, formation of peroxynitrite and reactive oxygen species in human chronic renal transplant failure.
Topics: Adult; Female; Graft Rejection; Humans; Immunohistochemistry; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Reactive Oxygen Species; Transplantation, Homologous; Tyrosine | 2002 |
Peroxynitrite affects exocytosis and SNARE complex formation and induces tyrosine nitration of synaptic proteins.
Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Exocytosis; Fluorescent Dyes; Glutamic Acid; Macromolecular Substances; Male; Membrane Proteins; Munc18 Proteins; Nerve Tissue Proteins; Peroxynitrous Acid; Proteins; Rats; Rats, Sprague-Dawley; SNARE Proteins; Sodium Bicarbonate; Sodium Dodecyl Sulfate; Synaptosomal-Associated Protein 25; Synaptosomes; Tyrosine; Vesicular Transport Proteins | 2002 |
Effect of nitric oxide in ischemia/reperfusion of the pancreas.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Female; Glutathione; Lipase; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidation-Reduction; Oximetry; Oxygen Consumption; Pancreas Transplantation; Pancreatitis; Regional Blood Flow; Reperfusion Injury; Swine; Tyrosine; Vascular Resistance | 2002 |
Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome.
Topics: Adolescent; Adult; Amidines; Animals; Benzylamines; Blood Proteins; Case-Control Studies; Disease Models, Animal; Disease Vectors; Enzyme Inhibitors; Female; Hantavirus Pulmonary Syndrome; Humans; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred NZB; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Orthohantavirus; Peromyscus; Reactive Nitrogen Species; Reactive Oxygen Species; Sin Nombre virus; Tyrosine | 2002 |
Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.
Topics: Animals; Cerebral Decortication; Corpus Striatum; DNA Damage; DNA Fragmentation; Gene Expression; Mice; Mice, Knockout; Neurotoxins; Nitro Compounds; Oxidation-Reduction; Phenanthridines; Propionates; Superoxide Dismutase; Superoxides; Tyrosine | 2002 |
PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice.
Topics: Animals; Arthritis, Rheumatoid; Cell Line; Cyclooxygenase 2; Freund's Adjuvant; Inflammation Mediators; Isoenzymes; Ligands; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Temporomandibular Joint; Transcription Factors; Tyrosine | 2002 |
Role of hyperglycemia in nitrotyrosine postprandial generation.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Male; Middle Aged; Oxidative Stress; Postprandial Period; Triglycerides; Tyrosine | 2002 |
Mitochondrial integrity and function in atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Disease Models, Animal; Disease Progression; DNA Damage; DNA, Mitochondrial; Heterozygote; Homozygote; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Phenotype; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2002 |
Detection of peroxynitrite-induced protein and DNA modifications.
Topics: Animals; Blood Proteins; Blotting, Western; DNA; Electrophoresis, Polyacrylamide Gel; Humans; Immunohistochemistry; Indicators and Reagents; Nitric Oxide; Peroxynitrous Acid; Proteins; Reactive Oxygen Species; Spectrophotometry; Superoxides; Tyrosine | 2002 |
Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury.
Topics: Acute Disease; Animals; Asbestos; Asbestosis; Bronchoalveolar Lavage Fluid; Chemotaxis; Enzyme Induction; Gene Expression Regulation; Inflammation; L-Lactate Dehydrogenase; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxidase; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice.
Topics: Amylases; Animals; Ceruletide; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-6; Lipase; Lipid Peroxidation; Male; Mice; Mice, Knockout; Microscopy, Fluorescence; P-Selectin; Pancreas; Pancreatitis; Peroxidase; Phenotype; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Hypertension, Renal; Immunoenzyme Techniques; Kidney Failure, Chronic; Kidney Glomerulus; Losartan; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Tyrosine | 2002 |
Activity profile in multiple sclerosis: an integrative approach. A preliminary report.
Topics: Adolescent; Adult; Autoantibodies; Biomarkers; CD40 Ligand; Cell Division; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Myelin Basic Protein; Nitric Oxide; Pilot Projects; Prospective Studies; Severity of Illness Index; T-Lymphocyte Subsets; Tyrosine | 2002 |
Plasma nitrotyrosine concentration relates to prognosis in human septic shock.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Aged; Nitric Oxide; Probability; Prognosis; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Shock, Septic; Survival Analysis; Tyrosine | 2002 |
Determination of nitrotyrosine and related compounds in biological specimens by competitive enzyme immunoassay.
Topics: Adolescent; Adult; Aged; Amino Acids; Animals; Binding, Competitive; Calibration; Cell Line; Child; Child, Preschool; Cross Reactions; Female; Humans; Immunoenzyme Techniques; Macrophages; Male; Mice; Middle Aged; Nasal Lavage Fluid; Nitrites; Rhinitis; Tyrosine | 2002 |
The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans.
Topics: Administration, Oral; Adolescent; Adult; Collagen; Cyclic GMP; Diet, Vegetarian; Female; Gastric Juice; Humans; Kinetics; Male; Nitrates; Platelet Aggregation; Platelet Function Tests; S-Nitrosothiols; Tyrosine | 2002 |
A role for superoxide in gentamicin-mediated nephropathy in rats.
Topics: Animals; Anti-Bacterial Agents; Enzyme Activation; Free Radical Scavengers; Gentamicins; Kidney; Lipid Peroxidation; Male; Manganese; Molecular Mimicry; Neutrophil Infiltration; Organometallic Compounds; Oxidants; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Renal Circulation; Renal Insufficiency; Superoxide Dismutase; Superoxides; Tyrosine | 2002 |
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats.
Topics: Animals; Endotoxemia; Heart Diseases; Hydrogen Peroxide; Lipopolysaccharides; Male; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxygen Consumption; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sepsis; Superoxides; Tyrosine; Xanthine Oxidase | 2002 |
Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo.
Topics: Animals; Blood Urea Nitrogen; Caspase 3; Caspases; Creatinine; Disease Models, Animal; DNA Fragmentation; Hydrolyzable Tannins; Ischemia; Kidney; Kidney Diseases; Lipopolysaccharides; Male; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Sanguisorba; Tannins; Tyrosine | 2002 |
Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia.
Topics: Animals; Cell Line; Cell Membrane; Chlorides; Cyclic AMP; Cyclic GMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; HeLa Cells; Humans; Mice; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Proteasome Endopeptidase Complex; Reactive Nitrogen Species; Reactive Oxygen Species; Respiratory Mucosa; Trachea; Tyrosine | 2002 |
Distinct renal injury in early atherosclerosis and renovascular disease.
Topics: Animals; Antioxidants; Arteriosclerosis; Cholesterol, Dietary; Disease Models, Animal; Disease Progression; Glomerular Filtration Rate; Hemodynamics; Hypercholesterolemia; Hypertension; Immunohistochemistry; Kidney; Kidney Function Tests; Kidney Tubules; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Regional Blood Flow; Renal Artery Obstruction; Swine; Tomography, X-Ray Computed; Tyrosine; Vasodilator Agents | 2002 |
Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes.
Topics: Adolescent; Adult; Autonomic Nervous System; Child; Diabetes Mellitus, Type 1; Dinoprost; F2-Isoprostanes; Female; Heart Conduction System; Humans; Male; Motor Neurons; Neural Conduction; Nitrates; Nitrites; Peripheral Nerves; Peroxynitrous Acid; Reference Values; Sweating; Time Factors; Tyrosine; Uric Acid | 2002 |
Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.
Topics: 2-Naphthylamine; Aldehydes; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucose; Glyoxal; Guanidines; Ketoses; Lysine; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2002 |
Immunocytochemical evidence for inducible nitric oxide synthase and cyclooxygenase-2 expression with nitrotyrosine formation in human hibernating myocardium.
Topics: Angiotensin-Converting Enzyme Inhibitors; Biopsy; Coronary Disease; Cyclooxygenase 2; Diuretics; Echocardiography; Humans; Immunohistochemistry; Isoenzymes; Membrane Proteins; Middle Aged; Myocardial Stunning; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Tyrosine | 2002 |
Lipoyl dehydrogenase catalyzes reduction of nitrated DNA and protein adducts using dihydrolipoic acid or ubiquinol as the cofactor.
Topics: Dihydrolipoamide Dehydrogenase; Guanine; NADP; Nitrogen Oxides; Oxidation-Reduction; Reactive Nitrogen Species; Thioctic Acid; Tyrosine; Ubiquinone; Xanthines | 2002 |
Association between nitrotyrosine levels and microvascular density in human breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Immunohistochemistry; Mass Spectrometry; Nitric Oxide; Tyrosine | 2002 |
Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding.
Topics: Amino Acid Sequence; Cell Line; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Molecular Sequence Data; Peroxynitrous Acid; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Receptors, Immunologic; Tyrosine | 2002 |
Fluctuation of serum NO(x) concentration at stroke onset in a rat spontaneous stroke model (M-SHRSP). Peroxynitrite formation in brain lesions.
Topics: Animals; Brain; Immunohistochemistry; Magnetic Resonance Imaging; Male; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Tyrosine | 2002 |
Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.
Topics: Animals; Aorta; Brain; Disease Models, Animal; Enzyme Activation; Extracellular Space; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Middle Cerebral Artery; Oxidative Stress; RNA, Messenger; Subarachnoid Hemorrhage; Superoxide Dismutase; Tyrosine; Vascular Patency; Vasospasm, Intracranial | 2002 |
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Heart Failure; Immunohistochemistry; Male; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Tyrosine; Vasomotor System; Ventricular Function, Left | 2002 |
Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.
Topics: Animals; Antibody Specificity; Female; gamma-Glutamyltransferase; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hyperoxia; Lung; Lung Diseases; Male; Membrane Proteins; Mice; Mice, Mutant Strains; Oxidative Stress; Oxygen; RNA, Messenger; Survival Rate; Tyrosine | 2002 |
Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats.
Topics: Animals; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Disease Models, Animal; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Tyrosine | 2002 |
Lipoteichoic acid from Staphylococcus aureus reduces renal ischemia/reperfusion injury.
Topics: Animals; Antioxidants; Cyclic N-Oxides; Kidney Diseases; Kidney Tubules; Lipopolysaccharides; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; P-Selectin; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Spin Labels; Staphylococcus aureus; Teichoic Acids; Tyrosine | 2002 |
Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages.
Topics: Apoptosis; Astrocytes; Astrocytoma; Catalysis; Culture Media, Conditioned; Ferric Compounds; Flow Cytometry; HIV Infections; HIV-1; Humans; Macrophages; Malondialdehyde; Metalloporphyrins; Peroxynitrous Acid; Tumor Cells, Cultured; Tyrosine | 2002 |
Nitric oxide and protein nitration in the cystic fibrosis airway.
Topics: Adult; Aged; Analysis of Variance; Cystic Fibrosis; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Reference Values; Respiratory Mechanics; Respiratory System; Tyrosine | 2002 |
Immunolocalization of inducible nitric oxide synthase and 3-nitrotyrosine in recurrently inflamed, human palatine tonsils.
Topics: Humans; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Palatine Tonsil; Peroxynitrous Acid; Recurrence; Tonsillitis; Tyrosine | 2002 |
Dietary vitamin E affects neutrophil distribution and genetic instability in murine Mutatect tumors.
Topics: Animals; Diet; Female; Fibrosarcoma; Hypoxanthine Phosphoribosyltransferase; Interleukin-8; Mice; Mice, Inbred C57BL; Mutation; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Transgenes; Tyrosine; Vitamin E | 2002 |
Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents.
Topics: Adenocarcinoma, Follicular; Adolescent; Adult; Carcinoma, Papillary; Child; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Thyroid Neoplasms; Tyrosine | 2002 |
Immunohistochemical study on the distribution of nitrotyrosine and neuronal nitric oxide synthase in aged rat cerebellum.
Topics: Aging; Animals; Cerebellar Cortex; Cerebellum; Image Processing, Computer-Assisted; Immunohistochemistry; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Purkinje Cells; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation | 2002 |
Role of reactive nitrogen intermediates and protein nitration during immune response against a rat histiocytoma.
Topics: Animals; Ascites; Ascitic Fluid; Blotting, Western; Cells, Cultured; Coculture Techniques; Histiocytoma, Benign Fibrous; Macrophage Activation; Macrophages; Neoplasm Transplantation; Neoplasms, Experimental; Nitrates; Nitrites; Proteins; Rats; Rats, Wistar; Skin Neoplasms; Tyrosine | 2002 |
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
Topics: Aging; Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Resistance; Humans; Insulin-Like Growth Factor I; Interleukin-1; Macaca fascicularis; Osteoarthritis; Oxidation-Reduction; Tyrosine | 2002 |
Termination of experimental galactosemia in rats, and progression of retinal metabolic abnormalities.
Topics: Animals; Disease Progression; Drug Administration Schedule; Galactose; Galactosemias; Glutathione; Hexoses; Lipid Peroxides; Male; Metabolic Diseases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Protein Kinase C; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Tyrosine | 2002 |
Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats.
Topics: Administration, Inhalation; Alkylating Agents; Animals; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cyclophosphamide; Immunohistochemistry; Leukocyte Count; Lipopolysaccharides; Lung; Male; Neutropenia; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response.
Topics: Allergens; Animals; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophils; Immunization; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Ovalbumin; Reactive Nitrogen Species; Respiratory Hypersensitivity; Tyrosine | 2002 |
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
The nitroxide antioxidant tempol is cerebroprotective against focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Brain Ischemia; Cyclic N-Oxides; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Infarction, Middle Cerebral Artery; Male; Maze Learning; Motor Activity; Neuroprotective Agents; Rats; Rats, Inbred SHR; Spin Labels; Treatment Outcome; Tyrosine | 2002 |
Simultaneous determination of 3-nitrotyrosine and tyrosine in plasma proteins of rats and assessment of artifactual tyrosine nitration.
Topics: Animals; Artifacts; Blood Proteins; Chromatography, High Pressure Liquid; Mass Spectrometry; Nitrates; Rats; Tyrosine | 2002 |
Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseases.
Topics: Animals; Blood Vessels; Coronary Vessels; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Tyrosine | 2002 |
Tyrosine nitration in prostaglandin H(2) synthase.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Culture Techniques; Endarterectomy, Carotid; Humans; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitrogen Oxides; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Rats; Seminal Vesicles; Sheep; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Tyrosine | 2002 |
Incorporation of 3-nitrotyrosine into the C-terminus of alpha-tubulin is reversible and not detrimental to dividing cells.
Topics: 3T3 Cells; Animals; Brain; Carboxypeptidases; Carcinoma; Cell Death; Cells, Cultured; CHO Cells; COS Cells; Cricetinae; HeLa Cells; Humans; Kinetics; Lung Neoplasms; Mice; Microtubules; Rats; Tubulin; Tyrosine | 2002 |
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
Topics: Animals; Antioxidants; beta Carotene; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Free Radicals; Hyperlipidemias; Immunohistochemistry; Male; Nitric Oxide; Nitroglycerin; Oxidative Stress; Rabbits; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine; Vasodilator Agents | 2002 |
Proteasome function and protein oxidation in the aged retina.
Topics: Aging; Aldehydes; Animals; Blotting, Western; Caseins; Chymotrypsin; Cysteine Endopeptidases; Eye Proteins; Male; Multienzyme Complexes; Oxidation-Reduction; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred BN; Rats, Inbred F344; Retina; Tyrosine | 2002 |
Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Female; Humans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pyramidal Cells; Tyrosine | 2002 |
Artifactual nitration controlled measurement of protein-bound 3-nitro-L-tyrosine in biological fluids and tissues by isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry.
Topics: Animals; Artifacts; Chemical Precipitation; Chromatography, Liquid; Female; Hydrolysis; Kidney; Protein Binding; Rats; Rats, Inbred F344; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2002 |
Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats.
Topics: Animals; Arteries; Blood Pressure; Catalase; Endothelium, Vascular; Fatty Acids, Unsaturated; In Vitro Techniques; Male; Muscle, Skeletal; Obesity; Oxidative Stress; Peroxynitrous Acid; Polyethylene Glycols; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats; Rats, Zucker; Superoxide Dismutase; Tyrosine; Vascular Patency; Vascular Resistance; Vasoconstriction; Vasomotor System | 2002 |
Hypothermia attenuates iNOS, CAT-1, CAT-2, and nitric oxide expression in lungs of endotoxemic rats.
Topics: Animals; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Computer Systems; Endotoxemia; Hypothermia; Immunoblotting; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Respiration; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2002 |
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Immunohistochemistry; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine | 2002 |
Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat.
Topics: Animals; Calpain; Cell Movement; Cyclooxygenase 2; Dose-Response Relationship, Drug; Glycoproteins; Immunohistochemistry; Intestinal Mucosa; Intestines; Isoenzymes; Liver; Lung; Male; Malondialdehyde; Multiple Organ Failure; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneum; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Tyrosine; Zymosan | 2002 |
Aldosterone-induced inflammation in the rat heart : role of oxidative stress.
Topics: Aldosterone; Animals; Antioxidants; Cardiomyopathies; Cell Division; Cell Movement; Fibrosis; Heart; Immunologic Factors; Inflammation; Lymphocytes; Macrophages; Male; Mineralocorticoid Receptor Antagonists; Monocytes; Myocardium; NADPH Oxidases; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone; Tyrosine | 2002 |
Myoglobin scavenges peroxynitrite without being significantly nitrated.
Topics: Animals; Apoproteins; Free Radical Scavengers; Globins; Immunohistochemistry; Metmyoglobin; Myoglobin; Nitrates; Oxyhemoglobins; Peroxynitrous Acid; Tryptophan; Tyrosine | 2002 |
Two-dimensional separation of the membrane protein sarcoplasmic reticulum Ca-ATPase for high-performance liquid chromatography-tandem mass spectrometry analysis of posttranslational protein modifications.
Topics: Amino Acid Sequence; Animals; Calcium-Transporting ATPases; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Hydrolysis; In Vitro Techniques; Molecular Sequence Data; Muscle, Skeletal; Peptide Mapping; Peroxynitrous Acid; Protein Processing, Post-Translational; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2002 |
Comparison of uric acid and ascorbic acid in protection against EAE.
Topics: Albumins; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Cell Line; Encephalomyelitis, Autoimmune, Experimental; Free Radicals; Immunohistochemistry; Iron; Lipid Peroxidation; Mice; Molsidomine; Myelin Sheath; Nitric Oxide; Oxygen; Peroxynitrous Acid; Rhodamines; Time Factors; Tyrosine; Uric Acid | 2002 |
Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries.
Topics: Animals; Biological Transport; Cattle; Cells, Cultured; Ceramides; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Isoenzymes; NADPH Oxidases; Peroxynitrous Acid; Phosphoproteins; Reactive Oxygen Species; Tyrosine | 2003 |
Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced inflammatory response by regulating nitric oxide synthase activity.
Topics: Animals; Cardiopulmonary Bypass; Cell Adhesion; Cytokines; Glutamine; Heart; Hemodynamics; HSP70 Heat-Shock Proteins; Inflammation; Male; Myocardium; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen Compounds; Preoperative Care; Rats; Rats, Sprague-Dawley; Respiration; Tyrosine | 2002 |
The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; DNA Fragmentation; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glycoside Hydrolases; Mice; NAD; NADPH Oxidases; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tyrosine; Zinc | 2002 |
A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity.
Topics: Animals; Blood Pressure; Blotting, Western; Body Weight; Diet; Dietary Carbohydrates; Dietary Fats; Female; Isoenzymes; Kidney; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred F344; Sodium Chloride; Tyrosine | 2003 |
Nitric oxide pathways in human bladder carcinoma. The distribution of nitric oxide synthases, soluble guanylyl cyclase, cyclic guanosine monophosphate, and nitrotyrosine.
Topics: Aged; Blotting, Western; Carcinoma; Cell Transformation, Neoplastic; Cyclic GMP; Free Radical Scavengers; Guanylate Cyclase; Humans; Immunohistochemistry; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Tyrosine; Urinary Bladder Neoplasms | 2002 |
Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis.
Topics: Adult; Chronic Disease; Female; Hepatitis, Autoimmune; Humans; Liver; Liver Cirrhosis, Biliary; Liver Diseases; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Severity of Illness Index; Tyrosine | 2002 |
Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Body Weight; Cerebral Cortex; Down-Regulation; Encephalitis; Exploratory Behavior; Male; Melatonin; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; RNA, Messenger; Tyrosine | 2002 |
Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation.
Topics: alpha-Tocopherol; Animals; Ascorbic Acid; Chromatography, High Pressure Liquid; gamma-Tocopherol; Inflammation; Kidney; Male; Nitrogen; Oxygen; Proteins; Rats; Rats, Inbred F344; Tissue Distribution; Tyrosine; Vitamin E; Zymosan | 2002 |
TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney.
Topics: Animals; Coloring Agents; Dose-Response Relationship, Drug; Hydrogen Peroxide; Immunohistochemistry; Kidney; Kidney Diseases; Male; Mice; Nitrogen; Oxidative Stress; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Tetrazolium Salts; Thiazoles; Triacetoneamine-N-Oxyl; Tyrosine; Urine | 2002 |
Regulation of the brain's vascular responses to oxygen.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperbaric Oxygenation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdialysis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxygen; Peroxynitrous Acid; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tyrosine; Vasomotor System | 2002 |
Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles.
Topics: Animals; Arterioles; Coronary Vessels; Female; Humans; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Microscopy, Video; Middle Aged; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Peptides; Peroxynitrous Acid; Potassium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Tyrosine; Vasodilation; Vasodilator Agents | 2002 |
Protein tyrosine nitration and peroxynitrite: reply.
Topics: Animals; Kinetics; Macrophages; Nitric Oxide; Peroxynitrous Acid; Proteins; Superoxides; Tyrosine | 2002 |
Generation of nitrotyrosine precedes activation of metalloproteinase in myocardium of hyperhomocysteinemic rats.
Topics: Animals; Blood Pressure; Enzyme Activation; Heart; Heart Rate; Hemodynamics; Hyperhomocysteinemia; Kinetics; Male; Matrix Metalloproteinase 2; Myocardium; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Tyrosine; Ventricular Function, Left | 2002 |
Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species.
Topics: Animals; Antioxidants; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Insulin; Lysine; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine | 2003 |
Type 2 nitric oxide synthase and protein nitration in chronic lung infection.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Fluorescent Antibody Technique; Lung; Lung Diseases; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pseudomonas Infections; Rats; Rats, Sprague-Dawley; Tyrosine | 2003 |
Increased plasma S-nitrosothiol levels in chronic haemodialysis patients.
Topics: Biomarkers; C-Reactive Protein; Erythrocytes; Female; Glutathione; Glutathione Peroxidase; Humans; Iron; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Reference Values; Renal Dialysis; S-Nitrosothiols; Transferrin; Tyrosine | 2003 |
The PrP-like protein Doppel binds copper.
Topics: Animals; Binding Sites; Binding, Competitive; Blotting, Western; Carbon; Chymotrypsin; Circular Dichroism; Copper; Diethyl Pyrocarbonate; Dose-Response Relationship, Drug; Free Radicals; GPI-Linked Proteins; Histidine; Kinetics; Mice; Nitrogen; Peptides; Prions; Protein Binding; Proteins; PrPC Proteins; Recombinant Proteins; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2003 |
Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice.
Topics: Amantadine; Animals; Antiviral Agents; Encephalitis, Viral; Female; Influenza A virus; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Orthomyxoviridae Infections; Recombination, Genetic; Tyrosine | 2002 |
The effect of selective inhibition of cyclooxygenase (COX)-2 on acute cardiac allograft rejection.
Topics: Acute Disease; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Furans; Graft Rejection; Graft Survival; Heart Transplantation; Immunohistochemistry; Isoenzymes; Male; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Inbred WF; RNA, Messenger; Transplantation, Homologous; Tyrosine | 2002 |
Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide.
Topics: Animals; Antibodies; Colony Count, Microbial; Escherichia coli; Escherichia coli Infections; Female; Genotype; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nephritis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Peroxynitrous Acid; Tyrosine; Urinary Tract Infections | 2003 |
Choice of different dyes to label tyrosine and nitrotyrosine.
Topics: 4-Chloro-7-nitrobenzofurazan; Electrophoresis, Capillary; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Spectrophotometry, Ultraviolet; Spectroscopy, Near-Infrared; Tyrosine | 2002 |
Prevention of impairment of cerebral blood flow autoregulation during acute stage of subarachnoid hemorrhage by gene transfer of Cu/Zn SOD-1 to cerebral vessels.
Topics: Adenoviridae; Animals; Arteries; Blood Vessels; Cerebrovascular Circulation; Gene Expression; Gene Transfer Techniques; Genetic Vectors; Humans; Male; NADPH Oxidases; Nitrates; Nitrites; Pia Mater; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Transgenes; Tyrosine; Vasomotor System | 2003 |
Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin.
Topics: 2,4-Dinitrophenol; Animals; Drug Interactions; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Male; Metalloporphyrins; Microdialysis; Molsidomine; Neurons; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Tyrosine | 2003 |
Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry.
Topics: Albumins; Gas Chromatography-Mass Spectrometry; Humans; Reference Values; Tyrosine | 2003 |
Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats.
Topics: Adenoviridae; Aging; Animals; beta-Galactosidase; Cell Line; Cyclic GMP; Genetic Vectors; Humans; Male; Microscopy, Confocal; Penile Erection; Penis; Rats; Rats, Inbred BN; Recombinant Fusion Proteins; RNA, Messenger; Superoxide Dismutase; Superoxides; Transfection; Tyrosine | 2003 |
Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.
Topics: Alleles; Black People; Female; Genetic Predisposition to Disease; Humans; Linkage Disequilibrium; Lupus Erythematosus, Systemic; Male; Microsatellite Repeats; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Factors; Sex Distribution; Tyrosine; White People | 2003 |
A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Liver; Lung; Male; Multiple Organ Failure; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Shock, Hemorrhagic; Sulfides; Tyrosine | 2002 |
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Ascorbic Acid; Biopterins; Cyclic AMP; Cyclic GMP; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; In Vitro Techniques; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Superoxides; Time; Tyrosine; Vasomotor System; Vitamin E | 2003 |
8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis.
Topics: Animals; Guanine; Guanosine; Lung; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pneumonia, Viral; Superoxides; Tyrosine | 2003 |
Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice.
Topics: Animals; Aorta; Apolipoproteins E; Arginine; Arteriosclerosis; Biopterins; Blotting, Western; Cholesterol; Disease Models, Animal; Immunohistochemistry; Isoenzymes; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Staining and Labeling; Thiobarbituric Acid Reactive Substances; Tyrosine | 2003 |
Preliminary report on nitric oxide-mediated oxidative damage in adolescent varicocele.
Topics: Adolescent; Blotting, Western; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Humans; Male; Nitric Oxide; Oxidative Stress; Testis; Tyrosine; Varicocele; Veins | 2003 |
Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Asphyxia; Cold Temperature; Enteral Nutrition; Enterocolitis, Necrotizing; Gene Expression; Inflammation Mediators; Interleukin-18; Intestines; Kupffer Cells; Liver; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia.
Topics: Animals; Aorta; Blood Pressure; Clofibric Acid; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Fibric Acids; Genotype; Homocysteine; Hyperhomocysteinemia; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Peroxisome Proliferators; Phenotype; Proteinuria; Tyrosine | 2003 |
Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia.
Topics: Coronary Vessels; Cyclic GMP; Dinoprost; Endothelium, Vascular; F2-Isoprostanes; Female; Heart Arrest, Induced; Humans; Male; Middle Aged; Myocardial Reperfusion Injury; Nitric Oxide; Reactive Oxygen Species; Tyrosine | 2003 |
Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Flavanones; Glutathione; Hesperidin; Hexanols; Lipid Peroxidation; Liver; Lysine; Male; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2003 |
Neuroprotective effect of urinary trypsin inhibitor against focal cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Behavior, Animal; Brain; Cell Count; Cerebrovascular Circulation; Glycoproteins; Hypoxia-Ischemia, Brain; Immunohistochemistry; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Nervous System Diseases; Neuroprotective Agents; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Trypsin Inhibitors; Tyrosine | 2003 |
Quantification of o,o'-dityrosine, o-nitrotyrosine, and o-tyrosine in cat urine samples by LC/ electrospray ionization-MS/MS using isotope dilution.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Isotopes; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2003 |
Relation of aging with oxidative protein damage parameters in the rat skeletal muscle.
Topics: Aging; Animals; Carbon; Lipid Peroxidation; Lipid Peroxides; Male; Muscle, Skeletal; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Sulfhydryl Compounds; Time Factors; Tyrosine | 2003 |
Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Autoantibodies; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Female; In Situ Nick-End Labeling; Interleukin-1; Lipopolysaccharides; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2003 |
Methylene blue photosensitized oxidation of hypotaurine in the presence of azide generates reactive nitrogen species: formation of nitrotyrosine.
Topics: Antioxidants; Azides; Hydrogen-Ion Concentration; Methylene Blue; Nitrates; Nitrites; Oxidation-Reduction; Oxygen; Photochemistry; Reactive Nitrogen Species; Sulfur; Taurine; Tyrosine | 2003 |
Postmenopausal hormone replacement therapy use decreases oxidative protein damage.
Topics: Blood Proteins; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Glutathione; Humans; Medroxyprogesterone Acetate; Middle Aged; Nitric Oxide; Oxidative Stress; Postmenopause; Sulfhydryl Compounds; Triglycerides; Tyrosine | 2002 |
Do endogenous opioids contribute to the bradycardia of rats with obstructive cholestasis?
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arginine; Bradycardia; Cholestasis; Dose-Response Relationship, Drug; Electrocardiography; Epinephrine; Guanidines; Heart Atria; Heart Rate; In Vitro Techniques; Male; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Opioid Peptides; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
Regulation of nitric oxide production in limb and ventilatory muscles during chronic exercise training.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Immunoblotting; Isoenzymes; Male; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Physical Conditioning, Animal; Physical Exertion; Rats; Rats, Sprague-Dawley; Respiratory Muscles; Specific Pathogen-Free Organisms; Tyrosine | 2003 |
Cerebrospinal fluid levels of nitric oxide and nitrotyrosine in neonates with mild hypoxic-ischemic encephalopathy.
Topics: Chromatography, High Pressure Liquid; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Luminescent Measurements; Nitric Oxide; Tyrosine | 2002 |
Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide.
Topics: Aneurysm; Animals; Blotting, Western; Cell Wall; Coronary Vessels; Disease Models, Animal; Hemorrhage; Immunohistochemistry; Inflammation; Lacticaseibacillus casei; Macrophages; Male; Mice; Mucocutaneous Lymph Node Syndrome; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Thrombosis; Time Factors; Tyrosine; Vasculitis | 2003 |
Immunohistochemical artifact for nitrotyrosine in eosinophils or eosinophil containing tissue.
Topics: Artifacts; Chromatography, High Pressure Liquid; Dithionite; Eosinophils; Gastric Mucosa; Humans; Hydrogen Peroxide; Immunoenzyme Techniques; Nitrogen Compounds; Ovalbumin; Oxidants; Oxidation-Reduction; Periodic Acid; Peroxidase; Tyrosine | 2002 |
Hyperhomocysteinemia induces renal hemodynamic dysfunction: is nitric oxide involved?
Topics: Animals; Cyclic GMP; Homocysteine; Hyperhomocysteinemia; Kidney Diseases; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Renal Circulation; Thiobarbituric Acid Reactive Substances; Tyrosine | 2003 |
Reactive nitrogen species block cell cycle re-entry through sustained production of hydrogen peroxide.
Topics: Animals; Catalase; Cell Cycle; Cells, Cultured; Cyclin D1; Epithelial Cells; Fluoresceins; Gene Expression Regulation; Hydrogen Peroxide; Mice; Molsidomine; Nitric Oxide Donors; Nitrogen Dioxide; Oxidants; Pulmonary Alveoli; Signal Transduction; Superoxide Dismutase; Transcription Factor AP-1; Tyrosine | 2003 |
High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species.
Topics: Cells, Cultured; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Epoprostenol; Gene Expression Regulation; Glucose; Humans; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Models, Biological; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxane A2; Tyrosine; Up-Regulation | 2003 |
Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats.
Topics: Administration, Topical; Animals; Aqueous Humor; Chromonar; Ciliary Body; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Intercellular Adhesion Molecule-1; Iris; Lipopolysaccharides; Male; Nitrates; Nitrites; Ophthalmic Solutions; P-Selectin; Platelet Aggregation Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Salmonella; Tumor Necrosis Factor-alpha; Tyrosine; Uveitis, Anterior | 2003 |
Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetic Retinopathy; Glutathione; Hyperglycemia; Insulin; Lipid Peroxides; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Retina; Tyrosine | 2003 |
Prevention of peroxynitrite-induced renal injury through modulation of peroxynitrite production by the Chinese prescription Wen-Pi-Tang.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Drugs, Chinese Herbal; Kidney; Lipid Peroxides; Lipopolysaccharides; Models, Chemical; Nitric Oxide Synthase; Nitrogen; Oxygen; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine; Urea; Xanthine Oxidase | 2002 |
Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery.
Topics: Angioplasty; Animals; Carotid Arteries; Carotid Stenosis; Enzyme Inhibitors; Glycoproteins; Hyperplasia; Male; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2003 |
The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans.
Topics: Adult; Blood Platelets; Blood Proteins; Chromatography, High Pressure Liquid; Diet; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nitrates; Nitrites; Platelet Aggregation; Saliva; Tyrosine | 2003 |
Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses.
Topics: Actins; Chemotaxis; Dimerization; Dose-Response Relationship, Drug; Humans; Molsidomine; Neutrophil Activation; Neutrophils; Nitric Oxide Donors; Peroxynitrous Acid; Phagocytosis; Reactive Oxygen Species; Respiratory Burst; Tyrosine | 2003 |
GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury.
Topics: Animals; Creatinine; Enzyme Inhibitors; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Poly Adenosine Diphosphate Ribose; Rats; Rats, Wistar; Reperfusion Injury; Sulfides; Tyrosine; Urea | 2003 |
Influence of epithelial lining fluid lipids on NO(2)-induced membrane oxidation and nitration.
Topics: Acetylcholinesterase; Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Bronchoalveolar Lavage Fluid; Catalase; Cell Membrane; Chelating Agents; Epithelial Cells; Erythrocytes; Glutathione; Humans; Liposomes; Lung; Male; Nitrogen Dioxide; Ovum; Oxidation-Reduction; Pentetic Acid; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tyrosine | 2003 |
3-Nitrotyrosine in atherosclerotic blood vessels.
Topics: Arteriosclerosis; Blood Vessels; Case-Control Studies; Humans; Molecular Diagnostic Techniques; Nitrates; Nitrites; Spectrophotometry; Thoracic Arteries; Tyrosine; Up-Regulation | 2003 |
Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Cholesterol, Dietary; Disease Models, Animal; Female; Hypercholesterolemia; Immunohistochemistry; Kidney; Kidney Function Tests; Nitric Oxide Synthase; Probability; Random Allocation; Receptors, LDL; Receptors, Oxidized LDL; Reference Values; Renal Circulation; Sensitivity and Specificity; Simvastatin; Swine; Tyrosine | 2003 |
Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714.
Topics: Amidines; Animals; Apoptosis; Aspartate Aminotransferases; DNA; Enzyme Inhibitors; Female; Hepatocytes; Heterocyclic Compounds, 2-Ring; Hot Temperature; In Situ Nick-End Labeling; Ischemia; L-Lactate Dehydrogenase; Liver; Liver Circulation; Microscopy, Confocal; Microscopy, Electron; Necrosis; Nitrates; Nitric Oxide Synthase; Nitrites; Reperfusion Injury; Swine; Time Factors; Tyrosine | 2003 |
The role of nitric oxide after a short period of liver ischemia-reperfusion.
Topics: Animals; Enzyme Inhibitors; Guanidines; Infusions, Parenteral; Liver; Male; Microcirculation; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Time Factors; Transaminases; Tyrosine | 2003 |
Mitochondrial targets of oxidative stress during renal ischemia/reperfusion.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Creatinine; Cytochrome c Group; Cytosol; Humans; In Situ Nick-End Labeling; Ischemia; Kidney; Male; Mitochondria; Oxidants; Oxidative Stress; Precipitin Tests; Rats; Rats, Inbred F344; Reperfusion Injury; Superoxide Dismutase; Time Factors; Tyrosine | 2003 |
Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps.
Topics: Acute Disease; Administration, Oral; Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Cell Movement; Chronic Disease; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Growth Inhibitors; Immunosuppressive Agents; Injections, Intraperitoneal; Lymphocyte Activation; Mice; Mice, Inbred Strains; Microglia; Myelin Basic Protein; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylacetates; Phenylbutyrates; Severity of Illness Index; Spinal Cord; T-Lymphocyte Subsets; Transcription Factor RelA; Tyrosine | 2003 |
Effects of angiotensin II on vascular endothelial cells: formation of receptor-mediated reactive nitrogen species.
Topics: Angiotensin II; Animals; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Reactive Nitrogen Species; Tyrosine | 2003 |
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
Topics: Animals; Argininosuccinate Synthase; Arthritis; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Penetrance; Peroxynitrous Acid; Phenotype; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Coronary Artery Disease; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Male; Middle Aged; Prospective Studies; Pyrroles; Risk Factors; Tyrosine | 2003 |
The nNOS inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum.
Topics: Animals; Body Temperature; Brain Chemistry; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Fever; Homovanillic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Neurofilament Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Peroxynitrous Acid; Temperature; Tyrosine | 2003 |
Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis.
Topics: Adult; Amidines; Benzylamines; Colitis, Ulcerative; Colon; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Interleukin-6; Intestinal Mucosa; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Oxidative stress and insulin requirements in patients with recent-onset type 1 diabetes.
Topics: Adolescent; Adult; Child; Diabetes Mellitus, Type 1; Dinoprost; F2-Isoprostanes; Female; Glycated Hemoglobin; Humans; Insulin; Islets of Langerhans; Longitudinal Studies; Male; Nitrates; Nitrites; Oxidative Stress; Tyrosine | 2003 |
Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems.
Topics: Anilino Naphthalenesulfonates; Animals; Blotting, Western; Brain; Caseins; Cattle; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Free Radicals; Kinetics; Multienzyme Complexes; Oxygen; Peptides; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Thymus Gland; Tryptophan; Tyrosine | 2003 |
Rosmarinic acid inhibits lung injury induced by diesel exhaust particles.
Topics: Administration, Oral; Animals; Antioxidants; Bronchoalveolar Lavage; Chemokine CCL2; Chemokine CCL4; Chemokines; Cinnamates; Cytokines; Depsides; Flavonoids; Free Radicals; Immunohistochemistry; Lung; Lung Injury; Macrophage Inflammatory Proteins; Male; Mice; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Phenols; Polyphenols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosmarinic Acid; Tyrosine; Vehicle Emissions | 2003 |
Hypoxia-ischemia induces thioredoxin expression and nitrotyrosine formation in new-born rat brain.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain; Hypoxia; Models, Anatomic; Oxidants; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Thioredoxins; Time Factors; Tyrosine | 2002 |
Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide.
Topics: Alanine Transaminase; Animals; Chemotaxis, Leukocyte; Ischemia; Lipid Peroxidation; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Necrosis; Neutrophils; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Reperfusion Injury; Resuscitation; Shock, Hemorrhagic; Superoxides; Tyrosine | 2003 |
Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species.
Topics: Animals; Aorta; Cell Line; Cells, Cultured; Cytokines; Enzyme Induction; Kinetics; Male; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Transfection; Tyrosine | 2003 |
Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease.
Topics: Actins; Adult; Blotting, Western; Colitis, Ulcerative; Colon; Colonic Diseases, Functional; Crohn Disease; Cytoskeletal Proteins; Female; Free Radicals; Humans; Immunoblotting; Intestinal Mucosa; Luminescent Measurements; Male; Nitric Oxide; Oxidation-Reduction; Tubulin; Tyrosine | 2003 |
Expression of inducible nitric oxide synthase and elevation of tyrosine nitration of a 32-kilodalton cellular protein in brain capillary endothelial cells from rats infected with a neuropathogenic murine leukemia virus.
Topics: 3T3 Cells; Animals; Brain; Capillaries; Cells, Cultured; Endothelium, Vascular; Leukemia Virus, Murine; Mice; Nervous System; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proteins; Rats; Rats, Inbred F344; Retroviridae Infections; Tumor Virus Infections; Tyrosine | 2003 |
Cyclosporin A disrupts bradykinin signaling through superoxide.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Animals; Antioxidants; Blotting, Western; Bradykinin; Cyclic GMP; Cyclosporine; Enzyme Activation; Free Radical Scavengers; GTP-Binding Proteins; Guanylate Cyclase; LLC-PK1 Cells; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Onium Compounds; Phospholipases; Quercetin; Receptor, Bradykinin B2; Receptors, Bradykinin; Signal Transduction; Solubility; Superoxides; Swine; Tyrosine; Vitamin K 3 | 2003 |
The nature of heme/iron-induced protein tyrosine nitration.
Topics: Animals; Brain; Heme; Hemeproteins; Hydrogen Peroxide; Kidney; Kinetics; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitrates; Organ Specificity; Peroxidase; Sodium Nitrite; Tyrosine | 2003 |
Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cell Differentiation; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Female; Free Radicals; Humans; Hypoxia, Brain; Immunohistochemistry; Infant, Newborn; Neuronal Plasticity; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Rats; Rats, Wistar; Tyrosine; Up-Regulation | 2003 |
Generation of activated sialoadhesin-positive microglia during retinal degeneration.
Topics: Animals; Apoptosis; CD11 Antigens; Cell Adhesion Molecules; Cell Division; Cell Movement; Disease Models, Animal; Immunoenzyme Techniques; In Situ Nick-End Labeling; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Mice, Mutant Strains; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Photoreceptor Cells; Proliferating Cell Nuclear Antigen; Receptors, Immunologic; Retinal Degeneration; Sialic Acid Binding Ig-like Lectin 1; Sialic Acids; Tyrosine | 2003 |
Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins.
Topics: Animals; Cell Line; Cell Membrane; Deoxyribonucleases; Histones; Hydrolases; Kinetics; Macrophages; Mice; Peroxynitrous Acid; Proteins; Substrate Specificity; Trypsin; Tyrosine | 2003 |
Evidence of nitric oxide synthase 2 activity in swine naturally infected with Actinobacillus pleuropneumoniae.
Topics: Actinobacillus Infections; Actinobacillus pleuropneumoniae; Animals; Antigens, Viral; Enzyme Induction; Immunohistochemistry; Lung; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pleuropneumonia; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Swine Diseases; Tyrosine | 2003 |
Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Cerebral Ventricles; Hippocampus; Infusions, Parenteral; Male; Microdialysis; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Wistar; Synaptophysin; Tyrosine | 2003 |
Lipid peroxidation and nitric oxide inactivation in postmenopausal women.
Topics: Adult; Aged; Arteriosclerosis; Cholesterol; Estradiol; Estrogens; Female; Humans; Lipid Peroxidation; Middle Aged; Nitric Oxide; Postmenopause; Premenopause; S-Nitrosothiols; Tyrosine; Vasodilation | 2003 |
HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7.
Topics: Animals; Blotting, Western; Caustics; Creatinine; Enzyme Induction; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Kidney; Kidney Diseases; Male; Oxidative Stress; Potassium Dichromate; Protoporphyrins; Rats; Rats, Wistar; Tin Compounds; Tyrosine | 2003 |
Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.
Topics: Animals; Blood-Retinal Barrier; Body Weight; Diabetes Mellitus, Experimental; Endothelial Growth Factors; Enzyme Inhibitors; Gene Expression; Intercellular Signaling Peptides and Proteins; Lipid Peroxidation; Lymphokines; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Retina; RNA, Messenger; Tyrosine; Uric Acid; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Hyperoxia causes inducible nitric oxide synthase-mediated cellular damage to the immature rat brain.
Topics: Animals; Blotting, Western; Brain; Brain Diseases; Hyperoxia; Immunohistochemistry; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2003 |
Hypobaric hypoxia modifies constitutive nitric oxide synthase activity and protein nitration in the rat cerebellum.
Topics: Altitude; Animals; Cerebellum; Endothelium, Vascular; Hypoxia; Immunohistochemistry; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2003 |
Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells.
Topics: Antioxidants; Arachidonic Acid; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cysteine Endopeptidases; Cytochrome P-450 CYP2E1; Drug Synergism; Endopeptidases; Humans; Iron; Leupeptins; Lipid Peroxides; Liver Neoplasms; Lysosomes; Membrane Potentials; Mitochondria, Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Tyrosine | 2003 |
Differential nitric oxide synthase expression during hepatic ischemia-reperfusion.
Topics: Animals; Blotting, Western; Disease Models, Animal; Fluorescent Antibody Technique; Ischemia; Liver; Liver Diseases; Liver Function Tests; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2003 |
A novel model for rapid induction of apoptosis in spiral ganglions of mice.
Topics: Animals; Apoptosis; Cell Death; Cisplatin; Disease Models, Animal; In Situ Nick-End Labeling; Intermediate Filament Proteins; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Peripherins; Peroxynitrous Acid; Spiral Ganglion; Tyrosine | 2003 |
Distribution of protein nitrotyrosine in synovial tissues of patients with rheumatoid arthritis and osteoarthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Blotting, Western; Female; Humans; Immunohistochemistry; Male; Middle Aged; Osteoarthritis; Peroxynitrous Acid; Staining and Labeling; Synovial Membrane; Tyrosine | 2003 |
Proteomic identification of nitrated proteins in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Brain Chemistry; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Phosphopyruvate Hydratase; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triose-Phosphate Isomerase; Tyrosine | 2003 |
Articular chondrocyte apoptosis in equine osteoarthritis.
Topics: Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Horse Diseases; Horses; Immunohistochemistry; In Situ Nick-End Labeling; Nitric Oxide; Osteoarthritis; Tyrosine | 2003 |
Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney.
Topics: Angiotensin II; Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Immunohistochemistry; Kidney; Male; Precipitin Tests; Rats; Rats, Wistar; Recombinant Proteins; Sensitivity and Specificity; Superoxide Dismutase; Tyrosine | 2003 |
Myeloperoxidase has directly-opposed effects on nitration reaction--study on myeloperoxidase-deficient patient and myeloperoxidase-knockout mice.
Topics: Adult; Animals; Enzyme-Linked Immunosorbent Assay; Humans; Hydrogen Peroxide; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitrites; Nitrogen Dioxide; Nitrosation; Oxidation-Reduction; Peroxidase; Reactive Nitrogen Species; Time Factors; Tyrosine | 2003 |
Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.
Topics: Animals; Antioxidants; Caspases; Catechin; Cell Cycle; Cell Line; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxides; Lipopolysaccharides; LLC-PK1 Cells; Male; Molsidomine; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Rhodamines; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2003 |
Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients.
Topics: Aged; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Lung; Macrophages, Alveolar; Male; Membrane Proteins; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Severity of Illness Index; Tyrosine | 2003 |
Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine.
Topics: Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intravenous; Lipopolysaccharides; Male; Models, Chemical; Nitrates; Nitrophenols; Nitrosation; Phenylacetates; Rats; Rats, Sprague-Dawley; Reference Standards; Tyrosine | 2003 |
Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts.
Topics: Animals; Biomarkers; Cholesterol, Dietary; Hyperlipidemias; Male; Malondialdehyde; Models, Animal; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Xanthine Dehydrogenase | 2003 |
Role of nitric oxide and peroxynitrite anion in lung injury induced by intestinal ischemia-reperfusion in rats.
Topics: Animals; Anions; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 2003 |
Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase.
Topics: Acute Disease; Animals; Autoimmune Diseases; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heart Rate; Myocarditis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Tyrosine | 2003 |
High glucose-induced tyrosine nitration in endothelial cells: role of eNOS uncoupling and aldose reductase activation.
Topics: Aldehyde Reductase; Animals; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Glucose; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrosation; Retinal Vessels; Superoxides; Tyrosine | 2003 |
Expression of nitrergic system and protein nitration in adult rat brains submitted to acute hypobaric hypoxia.
Topics: Animals; Atmospheric Pressure; Brain Chemistry; Cerebral Cortex; Hypoxia; Immunohistochemistry; Male; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Proteins; Rats; Rats, Wistar; Tyrosine | 2003 |
Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes.
Topics: Animals; Apoptosis; Biomarkers; Cardiopulmonary Bypass; Caspase 3; Caspases; Dinoprost; Endothelium, Vascular; F2-Isoprostanes; Female; Heart Arrest, Induced; Immunohistochemistry; Male; Models, Animal; Myocardial Reperfusion Injury; Myocytes, Cardiac; Signal Transduction; Swine; Tyrosine | 2003 |
Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide.
Topics: Alcohol Drinking; Animals; Cell Hypoxia; Cell Respiration; Central Nervous System Depressants; Chronic Disease; Ethanol; Liver; Male; Mitochondria, Liver; Nitric Oxide; Oxygen Consumption; Oxyhemoglobins; Rats; Rats, Sprague-Dawley; Tyrosine | 2003 |
Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis.
Topics: Animals; Bronchiolitis Obliterans; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Metalloporphyrins; Models, Animal; Peroxynitrous Acid; Rats; Rats, Inbred BN; Rats, Inbred Lew; Respiratory Mucosa; Trachea; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine | 2003 |
Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat.
Topics: Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Induction; Enzyme Inhibitors; Female; Isoenzymes; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrosation; Rats; Tyrosine | 2003 |
Cutting edge: MHC class II-restricted peptides containing the inflammation-associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cell-mediated immune response.
Topics: Amino Acid Sequence; Animals; Autoantigens; Base Sequence; Cell Line; CHO Cells; Columbidae; Cricetinae; Cytochrome c Group; Histocompatibility Antigens Class II; Humans; Immune Tolerance; Immunity, Cellular; Inflammation Mediators; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Molecular Sequence Data; Moths; Peptides; Tyrosine | 2003 |
Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease.
Topics: Adult; Blotting, Western; Chromatography, High Pressure Liquid; Copper; Humans; Iron; Male; Malondialdehyde; Monocytes; Nitrates; Nitric Oxide Synthase; Nitrosation; Oxidation-Reduction; Oxidative Stress; Retinal Vasculitis; Retinal Vessels; Spectrophotometry, Atomic; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tyrosine; Zinc | 2003 |
Super-marathon race increases serum and urinary nitrotyrosine and carbonyl levels.
Topics: Adult; Biomarkers; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Humans; Male; Middle Aged; Oxidative Stress; Physical Endurance; Reactive Oxygen Species; Running; Tyrosine | 2003 |
Nitrotyrosine in peripheral vascular disease.
Topics: Aged; Case-Control Studies; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Oxidants; Peripheral Vascular Diseases; Peroxynitrous Acid; Tyrosine | 2003 |
Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Female; Homozygote; Immunity, Innate; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phospholipids; Pneumonia; Pulmonary Surfactant-Associated Protein D; Pulmonary Surfactants; S-Nitrosothiols; Tyrosine | 2004 |
Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemokines; Disease Models, Animal; Immunohistochemistry; Inflammation Mediators; Macrophages, Alveolar; Male; Models, Cardiovascular; NF-kappa B; Peroxidase; Peroxynitrous Acid; Rats; Rats, Long-Evans; Reactive Nitrogen Species; Reperfusion Injury; Respiratory Distress Syndrome; Severity of Illness Index; Statistics as Topic; Transcription Factor AP-1; Transcriptional Activation; Tyrosine | 2003 |
Protein tyrosine nitration is triggered by nerve growth factor during neuronal differentiation of PC12 cells.
Topics: Animals; Cell Differentiation; Enzyme Inhibitors; Nerve Growth Factor; Neurons; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Protein Processing, Post-Translational; Proteins; Rats; Signal Transduction; Tubulin; Tyrosine | 2003 |
Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice.
Topics: Animals; Antioxidants; Blotting, Western; Chemotaxis, Leukocyte; Disease Models, Animal; Drug Evaluation, Preclinical; Immunohistochemistry; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Multiple Organ Failure; Neutrophils; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Poly(ADP-ribose) Polymerases; Pyrrolidines; Random Allocation; Thiocarbamates; Time Factors; Tyrosine; Zymosan | 2003 |
3-Nitrotyrosine immunoreactivity in olfactory receptor neurons of patients with Alzheimer's disease: implications for impaired odor sensitivity.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Case-Control Studies; Female; Humans; Immunohistochemistry; Male; Mental Status Schedule; Olfaction Disorders; Olfactory Receptor Neurons; Sensory Thresholds; Thiolester Hydrolases; Tyrosine; Ubiquitin Thiolesterase | 2003 |
Enzyme immunoassays for the investigation of protein nitration by air pollutants.
Topics: Air Pollutants; Allergens; Animals; Antigens, Plant; Immunoenzyme Techniques; Plant Proteins; Pollen; Proteins; Serum Albumin, Bovine; Tyrosine | 2003 |
Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Angiogenesis Inducing Agents; Animals; Apoptosis; Astrocytes; Brain Stem; Cell Count; Central Nervous System; Cytokines; Disease Models, Animal; Gene Targeting; Glial Fibrillary Acidic Protein; Growth Substances; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lymphocytes; Macrophages; Malondialdehyde; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Nerve Degeneration; Oxidative Stress; Staining and Labeling; Stem Cells; Teratogens; Tyrosine | 2003 |
Inducible nitric oxide synthase and nitrotyrosine in mice with radiation-induced lung damage.
Topics: Animals; Disease Models, Animal; Female; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Radiation Injuries, Experimental; Radiation Pneumonitis; Tyrosine | 2003 |
Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Bradykinin; Catalase; Coronary Vessels; Dose-Response Relationship, Drug; Echocardiography; Endothelium, Vascular; Female; Hemodynamics; Hypertrophy, Left Ventricular; In Vitro Techniques; Ketanserin; Male; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pterins; Serotonin; Serotonin Antagonists; Superoxide Dismutase; Swine; Tyrosine | 2003 |
Oxidative protein damage parameters in plasma in chronic experimental diabetes in rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Lipid Peroxides; Male; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Tyrosine | 2003 |
ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arterioles; Blood Pressure; Culture Techniques; Dansyl Compounds; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Neutrophils; Oxidative Stress; Proteins; Rats; Rats, Wistar; Receptor, Endothelin A; Sodium Chloride; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2003 |
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals.
Topics: Blotting, Western; Cyclic N-Oxides; Dimerization; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Globins; Humans; Hydrogen Peroxide; Immunohistochemistry; Iron; Isomerism; Methemoglobin; Nitrates; Nitrites; Oxygen; Oxyhemoglobins; Peroxynitrous Acid; Spectrophotometry; Spin Labels; Superoxides; Tyrosine | 2003 |
Protein nitration in rat lungs during hyperoxia exposure: a possible role of myeloperoxidase.
Topics: Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Cell Line; Edema; Hemorrhage; Hyperoxia; Lung; Macrophages, Alveolar; Neutrophils; Nitrates; Nitrites; Peptide Fragments; Peroxidase; Proteins; Pulmonary Surfactant-Associated Protein A; Rats; Respiratory Mucosa; Time Factors; Tyrosine | 2003 |
Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite.
Topics: 4-Chloro-7-nitrobenzofurazan; Disulfides; Fluorescent Dyes; Free Radicals; Glutathione; Humans; Hydrogen Peroxide; Kinetics; Oxidants; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Serum Albumin; Sulfenic Acids; Sulfhydryl Compounds; Tyrosine | 2003 |
Analysis of nitrated proteins by nitrotyrosine-specific affinity probes and mass spectrometry.
Topics: Chemistry Techniques, Analytical; Humans; Mass Spectrometry; Molecular Probes; Proteins; Serum Albumin; Tyrosine | 2003 |
Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition.
Topics: Animals; Calcium; Cytochromes c; Drug Administration Schedule; In Vitro Techniques; Ion Channels; Male; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Proteins; Peroxynitrous Acid; Proteomics; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2004 |
[Determination of nitrotyrosine with catalytic spectrophotometry combining the substitution of nitroxyl by iodide].
Topics: Catalysis; Iodides; Iodine; Nitrogen Oxides; Sensitivity and Specificity; Spectrophotometry; Tyrosine | 2002 |
Sensory neurons with activated caspase-3 survive long-term experimental diabetes.
Topics: Animals; Apoptosis; Axons; Caspase 3; Caspases; Cell Nucleus; Cell Survival; Cytochrome c Group; Diabetes Mellitus, Experimental; In Situ Nick-End Labeling; Macrophages; Male; Microscopy, Electron; Neurons, Afferent; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Tyrosine | 2003 |
Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants.
Topics: Adult; Aged; Antioxidants; Apoptosis; Colitis, Ulcerative; Crohn Disease; Female; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Tyrosine; Xanthine Oxidase | 2003 |
Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits.
Topics: Animals; Catheterization; Constriction, Pathologic; Dilatation, Pathologic; Down-Regulation; Iliac Artery; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Rabbits; Superoxide Dismutase; Tunica Intima; Tunica Media; Tyrosine | 2003 |
The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.
Topics: Albuminuria; Animal Population Groups; Animals; Blood Pressure; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glycation End Products, Advanced; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Kinetics; Lysine; Models, Biological; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility; Thiazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine | 2003 |
Effect of high glucose on vasculature.
Topics: Animals; Blood Vessels; Cells, Cultured; Diabetes Mellitus; Endothelium, Vascular; Enzyme Activation; Glucose; Heart; Humans; Hyperglycemia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Rats; Superoxides; Tyrosine; Up-Regulation | 2003 |
Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Capillaries; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Glutathione; Immunohistochemistry; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2004 |
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut.
Topics: Animals; Benzhydryl Compounds; Blood Pressure; Epoxy Compounds; Immunologic Factors; Intercellular Adhesion Molecule-1; Interleukin-1; Intestinal Mucosa; Intestines; Ligands; Male; Malondialdehyde; Peroxidase; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; Rosiglitazone; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine; Vasodilator Agents | 2003 |
Hypoxia-induced acute lung injury in murine models of sickle cell disease.
Topics: Acute Disease; Anemia, Sickle Cell; Animals; Disease Models, Animal; Hemoglobin, Sickle; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Lung Diseases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tyrosine | 2004 |
Nitric oxide system and protein nitration are modified by an acute hypobaric hypoxia in the adult rat hippocampus.
Topics: Animals; Blotting, Western; Cell Count; Disease Models, Animal; Endothelium, Vascular; Glial Fibrillary Acidic Protein; Hippocampus; Hypoxia; Immunohistochemistry; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2003 |
C-reactive protein decreases prostacyclin release from human aortic endothelial cells.
Topics: Aorta; Ascorbic Acid; C-Reactive Protein; Cells, Cultured; Coronary Vessels; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Epoprostenol; Free Radical Scavengers; Humans; Intramolecular Oxidoreductases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Prostaglandins F; Tyrosine; Uric Acid | 2003 |
Mononuclear phagocyte xanthine oxidoreductase contributes to cytokine-induced acute lung injury.
Topics: Allopurinol; Animals; Apoptosis; Cell Differentiation; Cytokines; Enzyme Induction; Enzyme Inhibitors; Interferon-gamma; Interleukin-1; Lung; Male; Phagocytes; Pneumonia; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Tungsten; Tyrosine; Xanthine Oxidase | 2004 |
Cardiac nerves affect myocardial stunning through reactive oxygen and nitric oxide mechanisms.
Topics: Animals; Coronary Stenosis; Denervation; Enzyme Inhibitors; Heart; Hemodynamics; Immunohistochemistry; Models, Animal; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Necrosis; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Reactive Oxygen Species; Swine; Tyrosine | 2003 |
Myeloperoxidase-positive inflammatory cells participate in bile duct damage in primary biliary cirrhosis through nitric oxide-mediated reactions.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Bile Ducts; Epithelial Cells; Humans; Liver Cirrhosis, Biliary; Macrophages; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Tyrosine | 2003 |
The black box of lung redox.
Topics: Humans; Lung; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Superoxides; Tyrosine; Xanthine Oxidase | 2003 |
Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways.
Topics: Aged; Allopurinol; Breath Tests; Enzyme Inhibitors; Female; Humans; Lung; Male; Middle Aged; Nitric Oxide; Pulmonary Disease, Chronic Obstructive; Reactive Nitrogen Species; Sputum; Tyrosine; Xanthine Oxidase | 2003 |
The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia.
Topics: Animals; Blotting, Western; Brain Ischemia; Calmodulin; Carotid Artery, Internal, Dissection; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; Immunohistochemistry; Indazoles; Ischemic Attack, Transient; Male; Microdialysis; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Reperfusion; Time Factors; Tyrosine | 2003 |
Cardiomyopathy in a murine model of AIDS: evidence of reactive nitrogen species and corroboration in human HIV/AIDS cardiac tissues.
Topics: Adult; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cardiomyopathy, Dilated; Disease Progression; Echocardiography; Female; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microscopy, Electron; Murine Acquired Immunodeficiency Syndrome; Myocardium; Reactive Nitrogen Species; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; T-Lymphocytes; Tyrosine | 2003 |
Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.
Topics: Animals; Cerebrovascular Circulation; Hyperbaric Oxygenation; Hyperoxia; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Tyrosine; Vasoconstriction | 2003 |
Amelioration of cisplatin toxicity by a fermented grain food product.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antioxidants; Blood Urea Nitrogen; Cisplatin; Creatinine; Deoxyguanosine; Diet; Edible Grain; Fermentation; Intestines; Kidney; Lipid Peroxidation; Male; Nitrates; Nitrites; Rats; Rats, Inbred F344; Tyrosine; Weight Loss | 2002 |
The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Cyclooxygenase 2; Enzyme Inhibitors; Isoenzymes; Kidney Tubules; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine; Tyrphostins | 2003 |
Oxidative damage of the gastric mucosa in Helicobacter pylori positive chronic atrophic and nonatrophic gastritis, before and after eradication.
Topics: Adult; Aged; Chronic Disease; Female; Gastric Mucosa; Gastritis; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Male; Metaplasia; Middle Aged; Tyrosine | 2003 |
Relationship between protein nitration and oxidation and development of hyperoxic seizures.
Topics: Animals; Brain; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Hyperbaric Oxygenation; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Superoxide Dismutase; Time Factors; Tyrosine | 2003 |
A new pitfall in detecting biological end products of nitric oxide-nitration, nitros(yl)ation and nitrite/nitrate artefacts during freezing.
Topics: Animals; Aorta; Buffers; Cryopreservation; Cysteine; Freezing; Humans; Hydrogen-Ion Concentration; Nitrates; Nitric Oxide; Nitrites; Nitrophenols; Nitroso Compounds; Phosphates; Potassium Compounds; Rats; S-Nitrosothiols; Serum Albumin, Bovine; Tyrosine | 2003 |
Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation.
Topics: Acute Disease; Animals; Anthocyanins; Carrageenan; Dinoprostone; Exudates and Transudates; Fruit; Glucosides; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Lung; Male; Malondialdehyde; Neutrophils; Nitrates; Nitrites; Peroxidase; Plant Extracts; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2003 |
Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface.
Topics: Aldosterone; Animals; Calcium; Cell Separation; Coronary Vessels; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation; Genes, MHC Class II; Hydrogen Peroxide; Hyperaldosteronism; Leukocytes, Mononuclear; Lymphocyte Activation; Magnesium; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Tyrosine | 2003 |
Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Culture Techniques; Cells, Cultured; Deoxyguanosine; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Humans; Mannitol; Mesylates; NADH, NADPH Oxidoreductases; NADPH Oxidases; Oxidative Stress; Protein Kinase C; Protein Kinase C beta; Pyrroles; Time Factors; Tyrosine; Umbilical Veins | 2003 |
Evaluation of the antioxidant response in the plasma of healthy or hypertensive subjects after short-term exercise.
Topics: Adult; Aged; Antioxidants; Exercise; Exercise Test; Female; Humans; Hypertension; Male; Middle Aged; Phosphatidylcholine-Sterol O-Acyltransferase; Reference Values; Time Factors; Tyrosine | 2003 |
Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
Topics: Animals; Antioxidants; Blood Vessels; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Hypercholesterolemia; In Vitro Techniques; Lipids; Male; Nitrates; Nitric Oxide; Nitrites; Rabbits; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors; Tyrosine; Vasodilation | 2003 |
Pyrrolidine dithiocarbamate reduces the severity of cerulein-induced murine acute pancreatitis.
Topics: Amylases; Animals; Antioxidants; Blotting, Western; Ceruletide; Edema; I-kappa B Proteins; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Lipase; Lipid Peroxidation; Male; Mice; Necrosis; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Pancreatitis; Peroxidase; Pyrrolidines; Rats; Thiocarbamates; Tyrosine; Up-Regulation | 2003 |
Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.
Topics: Animals; Astrocytes; Behavior, Animal; Benzamides; Benzopyrans; Cell Death; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Hypoglycemia; Isoquinolines; Male; Maze Learning; Mice; Mice, Knockout; Neurons; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Time Factors; Treatment Outcome; Tyrosine | 2003 |
Alveolar macrophage cytotoxicity for normal lung fibroblasts is mediated by nitric oxide release.
Topics: Animals; Cell Culture Techniques; Cell Survival; Coculture Techniques; Culture Media; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Fibroblasts; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Lung; Macrophages, Alveolar; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells.
Topics: Adenoviridae; Animals; Blood Pressure; Eicosanoids; Endothelial Cells; Endothelium; Endothelium, Vascular; Enzyme Activation; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Injections, Intravenous; Kupffer Cells; Liver; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Radioimmunoassay; Spleen; Time Factors; Tyrosine | 2003 |
Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antibodies, Monoclonal; Blood Cells; CD18 Antigens; Cell Line, Tumor; Complement System Proteins; Cytotoxicity, Immunologic; Deoxyguanosine; Disease Progression; Drug Administration Schedule; Fibrosarcoma; Granulocytes; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neutrophil Infiltration; Neutrophils; Phenotype; Time Factors; Tyrosine | 2003 |
Nitrotyrosine formation in splenic toxicity of aniline.
Topics: Administration, Oral; Aniline Compounds; Animals; Blotting, Western; Enzyme Induction; Immunohistochemistry; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Spleen; Tyrosine | 2003 |
NMDA receptor regulation of nNOS phosphorylation and induction of neuron death.
Topics: Animals; Apoptosis; Calcineurin; Calcineurin Inhibitors; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Situ Nick-End Labeling; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2003 |
A derivatization assay using gaschromatography/negative chemical ionization tandem mass spectrometry to quantify 3-nitrotyrosine in human plasma.
Topics: Adult; Artifacts; Calibration; Gas Chromatography-Mass Spectrometry; Humans; Molecular Structure; Sensitivity and Specificity; Time Factors; Tyrosine | 2003 |
Is nitrotyrosine a footprint of nitric oxide release?
Topics: Animals; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; Kidney; Neurons; Nitric Oxide; Nitric Oxide Synthase; Tissue Distribution; Tyrosine | 2003 |
Distribution of nitric oxide synthases and nitrotyrosine in the kidney of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Endothelium, Vascular; Hypertension; Immunohistochemistry; Kidney; Male; Models, Cardiovascular; Neurons; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tissue Distribution; Tyrosine | 2003 |
Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process.
Topics: Amino Acid Sequence; Chitin; Electrochemistry; Escherichia coli Proteins; Esters; Free Radicals; Hydrolysis; Kinetics; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Chain Initiation, Translational; Peptide Fragments; Plasmids; Protein Structure, Tertiary; Ribonucleotide Reductases; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2003 |
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycosaminoglycans; Guanidines; Injections, Intra-Articular; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Synovial Membrane; Synovitis; Tyrosine; Uric Acid; Zymosan | 2004 |
Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Bacteremia; Blood Glucose; Blood Pressure; Down-Regulation; I-kappa B Kinase; I-kappa B Proteins; Interleukin-10; Interleukin-6; Leukocyte Count; Ligands; Lung; Male; Microbodies; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Neutrophil Infiltration; NF-kappa B; NF-KappaB Inhibitor alpha; Poly(ADP-ribose) Polymerases; Prostaglandin D2; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sepsis; Signal Transduction; Survival Rate; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Evidence for radical formation at Tyr-353 in Mycobacterium tuberculosis catalase-peroxidase (KatG).
Topics: Amino Acid Sequence; Bacterial Proteins; Catalase; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radicals; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Nitric Oxide; Oxidoreductases; Peroxides; Structure-Activity Relationship; Tryptophan; Tyrosine | 2004 |
Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen.
Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Azoles; Cell Cycle Proteins; Cellular Senescence; Diabetes Mellitus; Endothelial Cells; Endothelium, Vascular; In Vitro Techniques; Isoindoles; Microcirculation; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide; Obesity; Organoselenium Compounds; Rats; Rats, Zucker; Tyrosine; Vasodilation; Vasodilator Agents | 2004 |
Soy protein diet ameliorates renal nitrotyrosine formation and chronic nephropathy induced by puromycin aminonucleoside.
Topics: Animals; Antimetabolites; Antioxidants; Blood Urea Nitrogen; Body Weight; Catalase; Cholesterol; Creatinine; Diet; Eating; Glutathione Peroxidase; Glycine max; Immunohistochemistry; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Lipids; Male; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Wistar; Soybean Proteins; Superoxide Dismutase; Tyrosine | 2004 |
Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma.
Topics: Animals; Arthritis, Experimental; Collagen Type II; Cyclooxygenase 2; Interleukin-1; Interleukin-6; Isoenzymes; Joints; Lipid Peroxidation; Mice; Mice, Inbred DBA; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine; Vasodilator Agents | 2003 |
Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats.
Topics: Acetylglucosaminidase; Allyl Compounds; Animals; Anti-Bacterial Agents; Antioxidants; Blood Urea Nitrogen; Body Weight; Carbon; Creatinine; Gentamicins; Immunohistochemistry; Kidney; Kidney Cortex; Kidney Tubules; Male; Necrosis; Olive Oil; Oxidative Stress; Oxygen; Plant Oils; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfides; Time Factors; Tyrosine | 2003 |
Calpain inhibitor I reduces intestinal ischemia-reperfusion injury in the rat.
Topics: Animals; Blood Pressure; Blotting, Western; Cysteine Proteinase Inhibitors; Glycoproteins; I-kappa B Proteins; Ileum; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Malondialdehyde; Neutrophils; NF-KappaB Inhibitor alpha; P-Selectin; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Shock; Splanchnic Circulation; Time Factors; Tyrosine | 2004 |
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration.
Topics: Animals; Catalysis; Cattle; Cytochromes c; Horses; Humans; Hydrogen Peroxide; Jurkat Cells; Mitochondria, Liver; Myocardium; Nitrates; Nitrites; Peroxidase; Phenylacetates; Rats; Recombinant Proteins; Serum Albumin, Bovine; Superoxide Dismutase; Tyrosine | 2004 |
A novel competitive ELISA for both free and protein-bound nitrotyrosine.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutaral; Humans; Mice; Peroxynitrous Acid; Phenylalanine; Phosphotyrosine; Protein Binding; Reactive Nitrogen Species; Tyrosine | 2003 |
Oxidative stress in severe pulmonary hypertension.
Topics: Arachidonic Acids; Guanosine; Humans; Hypertension, Pulmonary; Lung; Oxidative Stress; Severity of Illness Index; Superoxide Dismutase; Tyrosine | 2004 |
Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.
Topics: Antioxidants; Dose-Response Relationship, Drug; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Hypochlorous Acid; Inhibitory Concentration 50; Isoenzymes; Models, Biological; Models, Chemical; Nitric Oxide; Oxygen; Peroxynitrous Acid; Potassium; Protein Binding; Rhodamines; Sulfur; Thioctic Acid; Tyrosine | 2004 |
Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants.
Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; beta Carotene; Chromans; Cysteine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glucose; Lipid Peroxides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Retina; Selenium; Tyrosine | 2003 |
Deleterious activation of poly(ADP-ribose)polymerase-1 in brain after in vivo oxidative stress.
Topics: Animals; Apoptosis; Benzamides; Brain; Brain Diseases; Enzyme Activation; Immunohistochemistry; Male; Malonates; Oxidative Stress; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine | 2003 |
Effects of oxygen on the reactivity of nitrogen oxide species including peroxynitrite.
Topics: Anaerobiosis; Electron Spin Resonance Spectroscopy; Glutathione; Molsidomine; Morpholines; Nitric Oxide; Nitrogen Oxides; Nitrosamines; Nitrous Oxide; Oxygen; Peroxynitrous Acid; S-Nitrosoglutathione; Solutions; Tyrosine | 2004 |
Distribution of 3-nitrotyrosine in the nasal polyps of atopic patients.
Topics: Adult; Case-Control Studies; Eosinophils; Female; Humans; Hypersensitivity, Immediate; Immunohistochemistry; Male; Nasal Mucosa; Nasal Polyps; Peroxynitrous Acid; Retrospective Studies; Tyrosine | 2004 |
Selective prion protein binding to synaptic components is modulated by oxidative and nitrosative changes induced by copper(II) and peroxynitrite in cholinergic synaptosomes, unveiling a role for calcineurin B and thioredoxin.
Topics: 14-3-3 Proteins; Animals; Blotting, Western; Calcineurin; Carbocyanines; Choline O-Acetyltransferase; Copper Sulfate; Cyclophilin A; Cysteine; Dose-Response Relationship, Drug; Epitopes; Humans; In Vitro Techniques; Membrane Glycoproteins; Membrane Proteins; Mercaptoethanol; Nerve Tissue Proteins; Neurons; Nitrosation; Oxidation-Reduction; Peroxynitrous Acid; Prions; Protein Binding; Pyruvic Acid; Qa-SNARE Proteins; R-SNARE Proteins; Recombinant Proteins; S-Nitrosothiols; Sheep; Synapsins; Synaptic Vesicles; Synaptosomes; Tacrolimus Binding Proteins; Thioredoxins; Time Factors; Torpedo; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Use of a novel double-sandwich enzyme-linked immunosorbent assay method for assaying chondroitin sulfate proteoglycans that bear 3-nitrotyrosine core protein modifications, a previously unrecognized proteoglycan modification in hydrocephalus.
Topics: Animals; Blotting, Western; Cattle; Chick Embryo; Chondroitin Sulfate Proteoglycans; Enzyme-Linked Immunosorbent Assay; Humans; Hydrocephalus; Infant, Newborn; Infant, Premature; Peroxynitrous Acid; Rabbits; Sensitivity and Specificity; Serum Albumin, Bovine; Tyrosine | 2004 |
Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors.
Topics: Animals; Animals, Newborn; Cell Count; Cell Death; Cells, Cultured; Culture Media; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Kainic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; Peroxynitrous Acid; Quinoxalines; Rats; Rats, Wistar; Spinal Cord; Stem Cells; Tyrosine | 2003 |
Superoxide: a key player in hypertension.
Topics: Animals; Aorta; Blood Pressure; Culture Techniques; Hypertension; Kinetics; Manganese; Organometallic Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Tyrosine; Vasodilation | 2004 |
Binge ethanol exposure increases liver injury in obese rats.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Body Weight; Cytochrome P-450 CYP2E1; Ethanol; Fatty Acids, Nonesterified; Glutathione; Ion Channels; Lipid Peroxidation; Liver; Male; Membrane Transport Proteins; Mitochondrial Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Obesity; Organ Size; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Zucker; Tyrosine; Uncoupling Protein 2 | 2003 |
Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice.
Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Body Weight; Cytochrome P-450 CYP2E1; Endotoxins; Ethanol; Free Radicals; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Peroxynitrite delivery methods for toxicity studies.
Topics: Animals; Cells, Cultured; Dimerization; Drug Delivery Systems; Humans; Hypoxanthine; Models, Chemical; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Toxicity Tests; Tyrosine; Uric Acid; Xanthine Oxidase | 2004 |
The protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Blotting, Western; Hemodynamics; Lipopolysaccharides; Lung; Male; Malondialdehyde; Nitric Oxide; Organ Size; Peroxidase; Propofol; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Role of cyclic GMP on inhibition by nitric oxide donors of human eosinophil chemotaxis in vitro.
Topics: Adolescent; Adult; Blotting, Western; Cell Survival; Chemotaxis, Leukocyte; Cyclic GMP; Eosinophils; Female; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Nitric Oxide Donors; Nitroprusside; Penicillamine; Tetrazolium Salts; Thiazoles; Tyrosine | 2004 |
Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats.
Topics: Acridines; Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Calcium; Catalase; Cyclooxygenase Inhibitors; Desoxycorticosterone; Endothelium, Vascular; Hydrogen Peroxide; Hypertension; Immunohistochemistry; In Vitro Techniques; Luminescent Measurements; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oligopeptides; Oxidative Stress; Oxygen; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Superoxides; Tyrosine; Xanthine Oxidase | 2004 |
Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Hyperglycemia; Insulin; Interleukins; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reference Values; RNA; Streptozocin; Tyrosine | 2004 |
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis.
Topics: Animals; Antithrombins; DNA Damage; Enzyme Inhibitors; Female; Hematocrit; Hemoglobins; Immunohistochemistry; Indoles; Lipid Peroxidation; Lung; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerase Inhibitors; Pseudomonas aeruginosa; Pseudomonas Infections; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sepsis; Sheep; Time Factors; Tyrosine | 2004 |
Peroxynitrite and caspase-3 expression after ischemia/reperfusion in mouse cardiac arrest model.
Topics: Animals; Brain Ischemia; Caspase 3; Caspases; Heart Arrest, Induced; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Reperfusion Injury; Time Factors; Tyrosine | 2003 |
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hepatocytes; Hydrogen Peroxide; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine | 2003 |
Photoaging and oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Arginine; Cells, Cultured; Deoxyguanosine; Fibroblasts; Humans; Lysine; Mice; Mice, Hairless; Oxidative Stress; Skin; Skin Aging; Tyrosine; Ultraviolet Rays | 2003 |
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.
Topics: Aged; alpha-Synuclein; Blotting, Western; Carrier Proteins; Case-Control Studies; Cell Line; Cysteine Endopeptidases; Cytochromes c; DNA, Mitochondrial; Electron Transport Complex I; Female; Humans; Immunohistochemistry; Lewy Bodies; Male; Microscopy, Confocal; Microscopy, Electron; Middle Aged; Multienzyme Complexes; Nerve Tissue Proteins; Neuroblastoma; Neurofilament Proteins; Neurons; Parkinson Disease; Precipitin Tests; Proteasome Endopeptidase Complex; Staining and Labeling; Synucleins; Transgenes; Tubulin; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
Determination of oxidative protein and lipid damage in adult hypopituitary patients with GH deficiency.
Topics: Adult; Anthropometry; Body Composition; Female; Human Growth Hormone; Humans; Hypopituitarism; Lipid Peroxides; Lipoproteins, LDL; Male; Oxidative Stress; Statistics, Nonparametric; Sulfhydryl Compounds; Tyrosine | 2003 |
Neuronal nitric oxide synthase and N-methyl-D-aspartate neurons in experimental carbon monoxide poisoning.
Topics: Animals; Brain Chemistry; Calcium Channel Blockers; Carbon Monoxide Poisoning; Cyclic GMP; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Laser-Doppler Flowmetry; Male; Maze Learning; Mice; Mice, Knockout; Microelectrodes; Neurons; Neurotoxicity Syndromes; Neutropenia; Neutrophils; NG-Nitroarginine Methyl Ester; Nimodipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Platelet Count; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2004 |
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Chickens; Cytochromes c; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Free Radicals; Horses; Hydrogen Peroxide; Immunoblotting; Magnetics; Models, Chemical; Muramidase; Nitric Oxide; Nitrites; Oxygen; Peroxynitrous Acid; Rats; Superoxide Dismutase; Time Factors; Tyrosine | 2004 |
Melatonin reduces peroxynitrite-induced injury in aortic smooth muscle cells.
Topics: Animals; Aorta; Cell Survival; Cells, Cultured; DNA Damage; Free Radical Scavengers; Malondialdehyde; Melatonin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation.
Topics: Animals; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-1beta; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peptide Fragments; Peroxidase; Pleuropneumonia; Pneumonia; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Sulfides; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrome.
Topics: Analysis of Variance; Animals; Aorta; Endothelium, Vascular; Hyperbaric Oxygenation; Immunohistochemistry; Male; Malondialdehyde; Multiple Organ Failure; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Sprague-Dawley; Tyrosine; Vascular Diseases; Vasodilation; Zymosan | 2004 |
Tyrosine nitration impairs mammalian aldolase A activity.
Topics: Electrophoresis, Gel, Two-Dimensional; Fibroblasts; Fructose-Bisphosphate Aldolase; Humans; Nitrosation; Skin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2004 |
Nitrotyrosine, dityrosine, and nitrotryptophan formation from metmyoglobin, hydrogen peroxide, and nitrite.
Topics: Hydrogen Peroxide; Methemoglobin; Metmyoglobin; Myoglobin; Nitrites; Peroxidase; Peroxynitrous Acid; Tryptophan; Tyrosine | 2004 |
Nitric oxide synthase and NADPH-diaphorase after acute hypobaric hypoxia in the rat caudate putamen.
Topics: Altitude; Animals; Blood Vessels; Blotting, Western; Cell Count; Endothelium; Hypoxia; Immunohistochemistry; Male; NADPH Dehydrogenase; Neostriatum; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2004 |
Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Disease Models, Animal; Image Processing, Computer-Assisted; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Nerve Degeneration; Peroxynitrous Acid; Proteins; Time Factors; Tyrosine | 2004 |
Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat.
Topics: Aging; Animals; Body Weight; Cardiotonic Agents; Estrogens; Ethylenediamines; Female; Heart; Heart Ventricles; Myocardial Ischemia; Myocardial Reperfusion Injury; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Size; Organometallic Compounds; Ovariectomy; Rats; Rats, Sprague-Dawley; Recovery of Function; Superoxide Dismutase; Tyrosine; Uterus | 2004 |
Oxidatively damaged proteins of heart mitochondrial electron transport complexes.
Topics: Adenine Nucleotide Translocator 1; Aldehydes; Animals; Cattle; Electron Transport Chain Complex Proteins; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Intracellular Membranes; Mitochondria, Heart; Oxidation-Reduction; Oxygen Consumption; Porins; Protein Structure, Tertiary; Reactive Oxygen Species; Submitochondrial Particles; Tyrosine; Voltage-Dependent Anion Channels | 2004 |
Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling.
Topics: Animals; Borohydrides; Calcium; Calcium Signaling; Cells, Cultured; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; Linoleic Acid; Models, Biological; NF-kappa B; Nitric Oxide; Peroxynitrous Acid; Pulmonary Artery; Swine; Tyrosine | 2004 |
Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Copper; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Humans; Inflammation; NADP; NADPH-Ferrihemoprotein Reductase; Oxidative Stress; Phenanthrolines; Tyrosine | 2004 |
Inducible nitric oxide synthase and vascular endothelial growth factor are colocalized in the retinas of human subjects with diabetes.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glial Fibrillary Acidic Protein; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prospective Studies; Retina; Tyrosine; Vascular Endothelial Growth Factors | 2004 |
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.
Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Isoindoles; Japan; Kidney; Lipopolysaccharides; Lysine; Male; Nitric Oxide; Organoselenium Compounds; Peroxidase; Phytotherapy; Plant Extracts; Plant Roots; Proteinuria; Rats; Rats, Wistar; Reperfusion Injury; Rheum; Superoxide Dismutase; Tyrosine; Uric Acid; Zinc | 2004 |
Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cell Death; Humans; Immunohistochemistry; Middle Aged; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyramidal Cells; Temporal Lobe; Tyrosine | 2004 |
Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; CD11 Antigens; Cell Movement; Disease Models, Animal; Disease Progression; Female; Integrin alpha Chains; Lipid Peroxidation; Macrophages; Neutrophil Infiltration; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proteins; Rats; Rats, Wistar; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Tyrosine | 2004 |
Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin.
Topics: Animals; Antioxidants; Apolipoproteins; Fatty Acids, Monounsaturated; Female; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; In Vitro Techniques; Indoles; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rabbits; Smoking; Tyrosine; Vitamin E | 2004 |
Possible involvement of nitric oxide and peroxynitrite in the pathogenesis of human vocal polyps and nodules.
Topics: Adult; Aged; Antibodies; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Peroxynitrous Acid; Polyps; Tyrosine; Vocal Cords | 2005 |
Simvastatin prevents load-induced protein tyrosine nitration in overloaded hearts.
Topics: Animals; Antioxidants; Aorta; Constriction; Coronary Vessels; Enzyme Induction; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Isoenzymes; Male; Membrane Transport Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NADPH Dehydrogenase; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Phosphoproteins; Pressure; Proteins; Rats; Rats, Wistar; Simvastatin; Tyrosine; Ventricular Remodeling | 2004 |
Nitrotyrosine localization to dermal nerves in borderline leprosy.
Topics: Granuloma; Humans; Immunohistochemistry; Leprosy; Macrophages; Microscopy, Immunoelectron; Mycobacterium leprae; Nitric Oxide Synthase; Peripheral Nerves; S100 Proteins; Skin; Skin Diseases, Bacterial; Tyrosine | 2004 |
Plasma and urinary free 3-nitrotyrosine following cardiac angiography procedures with non-ionic radiocontrast media.
Topics: Adult; Aged; Aged, 80 and over; Coronary Angiography; Female; Humans; Male; Middle Aged; Radiopharmaceuticals; Tyrosine | 2004 |
Nitric oxide and superoxide impair human placental amino acid uptake and increase Na+ permeability: implications for fetal growth.
Topics: Amino Acids; Biological Transport; Female; Fetal Growth Retardation; Free Radicals; Humans; Infant, Newborn; Microvilli; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Placenta; Pregnancy; Sodium; Subcellular Fractions; Superoxides; Time Factors; Trophoblasts; Tyrosine | 2004 |
Downregulation of nitric oxide formation by cytosolic phospholipase A2-released arachidonic acid.
Topics: Animals; Arachidonic Acid; Cell Line, Tumor; Cytosol; Down-Regulation; Immunohistochemistry; Lipoxygenase; Mice; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Rats; Superoxides; Tyrosine | 2004 |
The nitration of tau protein in neurone-like PC12 cells.
Topics: Amino Acid Sequence; Animals; Cytoskeleton; Humans; Molecular Sequence Data; Neurons; Nitric Oxide; PC12 Cells; Peptides; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; tau Proteins; Tyrosine | 2004 |
Effect of aminoguanidine in ligature-induced periodontitis in rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Enzyme Inhibitors; Gingiva; Guanidines; Ligation; Lipid Peroxidation; Male; Mouth Mucosa; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase; Periodontitis; Poly(ADP-ribose) Polymerases; Random Allocation; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.
Topics: Animals; Antioxidants; Arteriosclerosis; Ascorbic Acid; Cardiotonic Agents; Coronary Circulation; Diet, Atherogenic; Dinoprost; Enzyme Induction; Female; Gene Expression Profiling; Gene Expression Regulation; Heart; Hypercholesterolemia; Hypoxia-Inducible Factor 1, alpha Subunit; Imaging, Three-Dimensional; Myocardial Ischemia; Neovascularization, Pathologic; Oxidative Stress; Superoxide Dismutase; Swine; Tomography, X-Ray Computed; Transcription Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vitamin E | 2004 |
Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or deficient in folate promotes early atherosclerotic inflammatory processes.
Topics: Animals; Aorta; Arteriosclerosis; Chemokine CCL2; Diet; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Hyperhomocysteinemia; Inflammation; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Methionine; NF-kappa B; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation.
Topics: Animals; Ascorbic Acid; Dogs; Electric Countershock; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Histocytochemistry; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peroxynitrous Acid; Superoxides; Tyrosine | 2004 |
Quantitative assessment of protein-bound tyrosine nitration in airway secretions from patients with inflammatory airway disease.
Topics: Aged; Asthma; Case-Control Studies; Chromatography, High Pressure Liquid; Electrochemistry; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Nitric Oxide; Proteins; Pulmonary Disease, Chronic Obstructive; Reference Values; Sensitivity and Specificity; Sputum; Tyrosine | 2004 |
Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Coloring Agents; Enzyme Inhibitors; Evans Blue; Matrix Metalloproteinase 9; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reperfusion Injury; Superoxides; Tyrosine | 2004 |
Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice.
Topics: Animals; Blotting, Northern; Bronchoalveolar Lavage Fluid; Female; Histocytochemistry; Lung; Lymphocyte Depletion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pneumocystis carinii; Pneumonia, Pneumocystis; Pulmonary Surfactant-Associated Protein D; Pulmonary Surfactants; RNA, Bacterial; Specific Pathogen-Free Organisms; Tyrosine | 2004 |
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease.
Topics: Animals; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Guanidines; Huntington Disease; Lactic Acid; Male; Neostriatum; Neuroglia; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Pyruvic Acid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Tyrosine | 2004 |
Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Tyrosine | 2004 |
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria.
Topics: Animals; Autoradiography; Blotting, Western; Cell Hypoxia; Electrophoresis, Gel, Two-Dimensional; Mitochondria, Liver; Nitrates; Oxygen; Proteins; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2004 |
Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney.
Topics: Animals; Diet; Hyperhomocysteinemia; Kidney; Male; Methionine; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiocarbamates; Tyrosine | 2004 |
Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Metalloporphyrins; Motor Neurons; Rats; Time Factors; Tubulin; Tyrosine | 2004 |
Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebrovascular Circulation; Free Radical Scavengers; Free Radicals; Humans; Hyperemia; Mice; Oxidative Stress; Peptide Fragments; Physical Stimulation; Reactive Oxygen Species; Regional Blood Flow; Somatosensory Cortex; Tyrosine | 2004 |
Nitric oxide synthase immunoreactivity in the nematode Trichinella britovi. Evidence for nitric oxide production by the parasite.
Topics: Animals; Antibodies, Protozoan; Blotting, Western; Immunohistochemistry; Larva; Microscopy, Electron; Molecular Weight; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Trichinella; Tyrosine | 2004 |
S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo.
Topics: Aldehydes; Animals; Biomarkers; Body Weight; Carboxylic Acids; Cysteine; Dinitrophenols; Energy Intake; Free Radical Scavengers; Gentamicins; Hydroxyl Radical; Immunohistochemistry; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine; Urine | 2004 |
Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-beta on the survival of axotomized retinal ganglion cells.
Topics: Adenoviridae; Animals; Cell Survival; Female; Gene Transfer Techniques; Genetic Vectors; Immunohistochemistry; Injections, Intraventricular; Interleukin-10; Interleukin-4; Microscopy, Confocal; Microscopy, Fluorescence; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Superior Colliculi; Transfection; Transforming Growth Factor beta; Tyrosine | 2004 |
Nitric oxide-derived species in synovial fluid from patients with juvenile idiopathic arthritis.
Topics: Adolescent; Adult; Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Leukocytes, Mononuclear; Macrophage Activation; Male; Nitric Oxide; Peroxidase; Reactive Nitrogen Species; Superoxides; Synovial Fluid; Tyrosine | 2004 |
Impaired Na+,K+-ATPase activity as a mechanism of reactive nitrogen species-induced cytotoxicity in guinea pig liver exposed to lipopolysaccharides.
Topics: Animals; Cell Death; Enzyme Activation; Escherichia coli; Escherichia coli Infections; Guinea Pigs; Lipopolysaccharides; Liver; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reactive Nitrogen Species; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2004 |
Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.
Topics: Animals; Antioxidants; Biopterins; Blotting, Western; Caloric Restriction; Endothelium, Vascular; Female; Fetal Nutrition Disorders; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tyrosine; Uterus; Vasodilation | 2004 |
Circulating free nitrotyrosine in obstructive sleep apnea.
Topics: Adult; Chromatography, Liquid; Humans; Hypoxia; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Sleep; Sleep Apnea, Obstructive; Tyrosine | 2004 |
Acute ammonia intoxication induces an NMDA receptor-mediated increase in poly(ADP-ribose) polymerase level and NAD metabolism in nuclei of rat brain cells.
Topics: Amide Synthases; Ammonia; Animals; Brain; Brain Chemistry; Cell Nucleus; Male; NAD; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Superoxides; Tyrosine | 2004 |
Effects of diabetes on plasma nitrotyrosine levels.
Topics: Blood Glucose; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Sex Factors; Smoking; Tyrosine | 2004 |
Relation between bladder cancer and protein oxidation.
Topics: Aged; Analysis of Variance; Biomarkers, Tumor; Blood Proteins; Carcinoma, Transitional Cell; Case-Control Studies; Humans; Iron; Lipid Peroxidation; Male; Middle Aged; Neoplasm Staging; Oxidation-Reduction; Oxidative Stress; Probability; Prognosis; Reference Values; Risk Assessment; Sensitivity and Specificity; Sulfhydryl Compounds; Tyrosine; Urinary Bladder Neoplasms | 2003 |
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.
Topics: Acute Disease; Analysis of Variance; Animals; Blotting, Western; Calpain; Ceruletide; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Mice; NF-kappa B; Nitric Oxide Synthase; Pancreatitis; Poly(ADP-ribose) Polymerases; Random Allocation; Respiratory Distress Syndrome; Tyrosine | 2004 |
Morphological and functional changes induced by the amino acid analogue 3-nitrotyrosine in mouse neuroblastoma and rat glioma cell lines.
Topics: Animals; Cell Division; Cell Line; Cell Nucleus; Cell Size; Cell Survival; Dose-Response Relationship, Drug; Glioma; Mice; Neuroblastoma; Neurodegenerative Diseases; Neuroglia; Neurons; Rats; Tubulin; Tyrosine | 2004 |
Protective effects of green tea catechins on cerebral ischemic damage.
Topics: Animals; Brain Ischemia; Catechin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Granulocyte Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Infarction, Middle Cerebral Artery; Interleukin-3; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Plant Extracts; Rats; Rats, Wistar; Recombinant Fusion Proteins; Recombinant Proteins; Tea; Tyrosine | 2004 |
Mechanistic studies of the isomerization of peroxynitrite to nitrate catalyzed by distal histidine metmyoglobin mutants.
Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Globins; Heme; Histidine; Hydrogen-Ion Concentration; Isomerism; Kinetics; Metmyoglobin; Mutation; Nitrates; Nitrogen; Peroxynitrous Acid; Tyrosine; Whales | 2004 |
Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Celiac Artery; Disease Models, Animal; Intercellular Adhesion Molecule-1; Intestine, Small; Ischemia; Isoquinolines; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Superior; Mesenteric Vascular Occlusion; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; Solubility; Tyrosine; Water | 2004 |
High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitis.
Topics: Animals; Colitis; Dinitrofluorobenzene; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Intestines; Lipoproteins, HDL; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 2004 |
Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines.
Topics: Antioxidants; Ascorbic Acid; Benzothiazoles; Chromatography, High Pressure Liquid; Clusiaceae; DNA Damage; Dose-Response Relationship, Drug; Hypochlorous Acid; Lipid Peroxidation; Lipids; Mass Spectrometry; Medicine, Chinese Traditional; Models, Chemical; Nitrogen; Peroxynitrous Acid; Phenol; Phospholipids; Sulfonic Acids; Superoxides; Tyrosine; Xanthine Oxidase; Xanthones | 2004 |
Chronic gastritis with expression of inducible nitric oxide synthase is associated with high expression of interleukin-6 and hypergastrinaemia.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Chronic Disease; Female; Gastric Mucosa; Gastrins; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-6; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2004 |
Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.
Topics: Animals; Biomarkers; Catalysis; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; Fluorescent Dyes; Guanidines; I-kappa B Proteins; Leukocytes; Metalloporphyrins; Models, Cardiovascular; Myocarditis; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine; Xanthenes | 2004 |
HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries.
Topics: Animals; Arteries; Endothelial Cells; Endothelium, Vascular; Female; HIV Protease Inhibitors; In Vitro Techniques; Luminescent Measurements; Male; Oxidative Stress; Perfusion; Ritonavir; Superoxides; Swine; Tyrosine; Vasodilation | 2004 |
Proteomic method for identification of tyrosine-nitrated proteins.
Topics: Animals; Cells, Cultured; Databases, Protein; Electrophoresis, Gel, Two-Dimensional; Humans; Phosphorylation; Phosphotyrosine; Proteins; Proteomics; Sequence Analysis, Protein; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2004 |
Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Liver Cirrhosis, Experimental; Male; NADPH Dehydrogenase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Thioacetamide; Tyrosine; Up-Regulation | 2004 |
Comparison of nitrotyrosine antibodies and development of immunoassays for the detection of nitrated proteins.
Topics: Air Pollutants; Animals; Antibodies; Antibodies, Monoclonal; Environmental Monitoring; Goats; Immunoassay; Mice; Rabbits; Sheep; Tyrosine | 2004 |
Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity.
Topics: Animals; Bacterial Translocation; Colitis; Goblet Cells; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Specific Pathogen-Free Organisms; Tyrosine | 2004 |
Peroxynitrite reaction with eye lens proteins: alpha-crystallin retains its activity despite modification.
Topics: alpha-Crystallins; Animals; Cattle; Lens, Crystalline; Molecular Chaperones; Oxidative Stress; Peroxynitrous Acid; Tryptophan; Tyrosine | 2004 |
The effects of antioxidants on peroxynitrite-induced changes in platelet proteins.
Topics: Antioxidants; Blood Platelets; Blood Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Nitrates; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Resveratrol; Stilbenes; Tyrosine | 2004 |
Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Biomarkers; Biotin; Caspase 3; Caspases; Cell Count; Disease Models, Animal; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Female; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Protein Transport; Rats; Rats, Wistar; Tyrosine | 2004 |
Expression of cyclooxygenase-2 and nitric oxide synthase 2 in swine ulcerative colitis caused by Salmonella typhimurium.
Topics: Animals; Colitis, Ulcerative; Cyclooxygenase 2; DNA Primers; Immunohistochemistry; Isoenzymes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salmonella Infections, Animal; Salmonella typhimurium; Swine; Swine Diseases; Tyrosine | 2004 |
Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats.
Topics: Acyl Coenzyme A; Animals; Animals, Newborn; Blotting, Western; Carnitine O-Palmitoyltransferase; Endotoxemia; Female; Heart; Male; Mitochondria, Heart; Nitrosation; Peroxynitrous Acid; Precipitin Tests; Rats; Rats, Wistar; Tyrosine | 2004 |
Methylguanidine reduces the development of non septic shock induced by zymosan in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Intestinal Mucosa; Intestines; Kidney; Lipid Peroxidation; Lung; Male; Methylguanidine; Mice; Neutrophils; Pancreas; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Shock; Tyrosine; Zymosan | 2004 |
Oxygen tension and inhaled nitric oxide modulate pulmonary levels of S-nitrosocysteine and 3-nitrotyrosine in rats.
Topics: Administration, Inhalation; Animals; Cysteine; Humans; Infant; Isoenzymes; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxygen; Rats; S-Nitrosothiols; Tyrosine | 2004 |
Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion.
Topics: Animals; Gastric Mucosa; Intercellular Adhesion Molecule-1; Ligands; Mice; Mice, Inbred BALB C; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; RNA, Messenger; Stomach; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice.
Topics: Animals; Cystathionine beta-Synthase; Endothelium, Vascular; Female; Hyperhomocysteinemia; Mesenteric Arteries; Mice; Mice, Knockout; Mice, Transgenic; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phenylephrine; Pregnancy; Pregnancy Complications; Pterins; Tyrosine; Vasodilation | 2004 |
Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Enzyme Inhibitors; Guinea Pigs; Immunohistochemistry; Isoquinolines; Lung; Male; Malondialdehyde; Mast Cells; Nitric Oxide; Ovalbumin; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Respiratory Mechanics; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Endogenous nitration of iron regulatory protein-1 (IRP-1) in nitric oxide-producing murine macrophages: further insight into the mechanism of nitration in vivo and its impact on IRP-1 functions.
Topics: Aconitate Hydratase; Animals; Blotting, Western; Catechin; Cell Line; Cytoplasm; Cytosol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Hydrogen Peroxide; Interferon-gamma; Iron; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Lipopolysaccharides; Macrophages; Mercaptoethanol; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Peroxidases; Peroxynitrous Acid; Protein Binding; Recombinant Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Salicylamides; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Biomarkers; Brain; Cells, Cultured; Disease Models, Animal; Down-Regulation; Glutamate-Ammonia Ligase; Lipid Peroxidation; Memory Disorders; Mice; Mice, Inbred Strains; Neurons; Oligonucleotides, Antisense; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Tyrosine | 2004 |
Tyrosine nitration in plasma proteins from patients undergoing hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Blood Proteins; Blotting, Western; Female; Humans; Image Processing, Computer-Assisted; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Renal Dialysis; Tyrosine | 2004 |
Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat.
Topics: Animals; Disease Models, Animal; DNA Damage; Hyperplasia; Joint Instability; Male; Mandibular Condyle; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Stress, Mechanical; Synovial Membrane; Synovitis; Temporomandibular Joint; Temporomandibular Joint Disorders; Tyrosine | 2004 |
Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biotransformation; Catalase; Free Radical Scavengers; Isoniazid; Mycobacterium bovis; Mycobacterium tuberculosis; Nitric Oxide; Oxidoreductases; Peroxidase; Peroxynitrous Acid; Prodrugs; Spin Trapping; Tyrosine | 2004 |
Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation.
Topics: Adolescent; Adult; Aged; Cadaver; Female; Humans; Immunohistochemistry; Liver Transplantation; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reoperation; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Donors; Tyrosine | 2004 |
Peroxynitrite decreases hemostasis in human plasma in vitro.
Topics: Blood Coagulation Factors; Blotting, Western; Coagulants; Dose-Response Relationship, Drug; Factor X; Hemostasis; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide Donors; Partial Thromboplastin Time; Peroxynitrous Acid; Plasma; Protein C; Prothrombin Time; Superoxide Dismutase; Thrombelastography; Tyrosine | 2004 |
Selective inducible nitric oxide inhibition can restore hemodynamics, but does not improve neurological dysfunction in experimentally-induced septic shock in rats.
Topics: Animals; Blood Pressure; Blotting, Western; Calcium; Cecum; Cerebral Cortex; Enzyme Inhibitors; Heart Rate; Hemodynamics; Interleukin-1; Lysine; Male; Nervous System Diseases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Shock, Septic; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Large-volume sample stacking-capillary electrophoresis used for the determination of 3-nitrotyrosine in rat urine.
Topics: Animals; Diabetes Mellitus, Experimental; Electrophoresis, Capillary; Rats; Reference Standards; Sensitivity and Specificity; Tyrosine | 2004 |
Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry.
Topics: Animals; Coxsackievirus Infections; Enterovirus B, Human; HeLa Cells; Humans; Immunity; Mice; Mice, Inbred C3H; Peroxynitrous Acid; RNA, Viral; Transfection; Tyrosine; Viral Structural Proteins; Virus Replication | 2004 |
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.
Topics: Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Epitopes; Gas Chromatography-Mass Spectrometry; Humans; Immunohistochemistry; Inflammation; Lipid Peroxides; Lipoproteins, HDL; Mass Spectrometry; Nitric Oxide; Nitrogen; Oxygen; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Taurine; Time Factors; Tunica Intima; Tyrosine | 2004 |
Peroxynitrite, a product between nitric oxide and superoxide anion, plays a cytotoxic role in the development of post-bypass systemic inflammatory response.
Topics: Animals; Cardiopulmonary Bypass; Free Radical Scavengers; Inflammation; Interleukin-6; Interleukin-8; Male; Nitrates; Nitric Oxide; Nitrites; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors; Tyrosine | 2004 |
Erythropoietin reduces the development of experimental inflammatory bowel disease.
Topics: Animals; Benzenesulfonates; Colitis; Erythropoietin; Immunohistochemistry; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1; Intestinal Mucosa; Male; Mice; Neutrophil Infiltration; Peroxidase; Poly Adenosine Diphosphate Ribose; Recombinant Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase.
Topics: Blotting, Northern; Cells, Cultured; E-Selectin; Endothelium, Vascular; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Glucose; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Nitrogen; Oscillometry; Oxidative Stress; Poly(ADP-ribose) Polymerases; RNA, Messenger; Time Factors; Tyrosine; Umbilical Veins; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2004 |
Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase.
Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stomach; Stomach Neoplasms; Tyrosine | 2004 |
Evaluation of nitrotyrosine-containing proteins in blood platelets.
Topics: Animals; Blood Platelets; Blotting, Western; Cattle; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Nitrates; Serum Albumin, Bovine; Tyrosine | 2004 |
Mechanisms of apoptosis induced by cisplatin in marginal cells in mouse stria vascularis.
Topics: Aldehydes; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cisplatin; Cytochromes c; Enzyme Activation; Immunohistochemistry; In Situ Nick-End Labeling; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Stria Vascularis; Tyrosine | 2004 |
M40403 prevents myocardial injury induced by acute hyperglycaemia in perfused rat heart.
Topics: Animals; Antioxidants; Cells, Cultured; DNA Damage; Endothelial Cells; Endothelium, Vascular; Glucose; Heart; Humans; In Vitro Techniques; Lipid Peroxidation; Male; Malondialdehyde; Manganese; Mitochondria; Myocardial Reperfusion Injury; Myocardium; Organometallic Compounds; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tyrosine | 2004 |
Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes.
Topics: Acute Disease; Angina, Unstable; Collateral Circulation; Coronary Artery Bypass; Diabetes Mellitus, Type 2; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Superoxides; Transcription Factors; Tyrosine; Vascular Endothelial Growth Factor A; Ventricular Function | 2004 |
Performance of quantitative analyses by liquid chromatography-electrospray ionisation tandem mass spectrometry: from external calibration to isotopomer-based exact matching.
Topics: Calibration; Chemical Precipitation; Chromatography, Liquid; Humans; Proteins; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2004 |
Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging.
Topics: Aging; Animals; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Myocardium; Nanotechnology; Proteins; Proteomics; Rats; Rats, Inbred BN; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo.
Topics: Amyloid beta-Protein Precursor; Animals; Binding Sites; Caenorhabditis elegans Proteins; Copper; Cysteine; Gliosis; Humans; Ion Transport; Membrane Proteins; Memory; Neurons; Neurotoxicity Syndromes; Peptides; Protein Structure, Tertiary; Proteins; Rats; Tyrosine | 2004 |
Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery.
Topics: Angioplasty, Balloon; Animals; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Male; Nitric Oxide Synthase; Rabbits; Regeneration; Subclavian Artery; Superoxide Dismutase; Tunica Intima; Tyrosine | 2004 |
[The nitrosative effect of peripheral ischemia-reperfusion on lung and preventive of caffeic acid phenethyl ester].
Topics: Animals; Bronchoalveolar Lavage Fluid; Caffeic Acids; Capillary Permeability; Cytokines; Hindlimb; Lung; Male; Malondialdehyde; Neutrophil Infiltration; NF-kappa B; Phenylethyl Alcohol; Rats; Rats, Wistar; Reperfusion Injury; Respiratory Distress Syndrome; Tourniquets; Tyrosine | 2004 |
Pulmonary MnSOD is nitrated following hepatic ischemia-reperfusion.
Topics: Animals; Biomarkers; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Ischemia; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Reperfusion; Reperfusion Injury; Respiratory Distress Syndrome; Sensitivity and Specificity; Severity of Illness Index; Superoxide Dismutase; Tyrosine | 2004 |
Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.
Topics: Animals; Azoles; Diaphragm; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Isoindoles; Lipid Peroxidation; Male; Muscle Contraction; Muscle Fatigue; omega-N-Methylarginine; Organoselenium Compounds; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2005 |
American Chemical Society meeting. Enzyme deactivates heart-friendly HDL.
Topics: Animals; Apolipoprotein A-I; Biomarkers; Cardiovascular Diseases; Cholesterol; Humans; Lipoproteins, HDL; Magnetic Resonance Imaging; Oxidation-Reduction; Peroxidase; Risk Factors; Tyrosine | 2004 |
Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure.
Topics: Adult; Cardiomyopathy, Dilated; Heart Rate; Humans; Myocardial Contraction; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stroke Volume; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2004 |
Antioxidative response for nitric oxide production in breast carcinoma.
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Papillary; Catalase; Female; Free Radical Scavengers; Humans; Middle Aged; Neoplasms, Ductal, Lobular, and Medullary; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxidation-Reduction; Oxidative Stress; Protein Isoforms; Superoxide Dismutase; Tyrosine; Vascular Endothelial Growth Factor A | 2004 |
UV photolysis of 3-nitrotyrosine generates highly oxidizing species: a potential source of photooxidative stress.
Topics: Hydrogen-Ion Concentration; Hydroxyl Radical; Kinetics; Oxidative Stress; Photolysis; Reactive Oxygen Species; Tyrosine; Ultraviolet Rays | 2004 |
WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock.
Topics: Animals; Blood Pressure; Ileum; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-1; Male; Neutrophils; P-Selectin; Peroxidase; Peroxisome Proliferators; Poly(ADP-ribose) Polymerases; Pyrimidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Shock; Splanchnic Circulation; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2004 |
Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Carrageenan; CD30 Ligand; Intercellular Adhesion Molecule-1; Ki-1 Antigen; Lung; Male; Membrane Glycoproteins; Mice; P-Selectin; Pleurisy; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Short-term inhibitory effects of nitric oxide on cytochrome P450-mediated drug metabolism: time dependency and reversibility profiles in isolated perfused rat livers.
Topics: Animals; Bile; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Inhibitors; Heme; In Vitro Techniques; Liver; Male; Microsomes, Liver; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pharmaceutical Preparations; Proteins; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Time Factors; Tyrosine | 2004 |
Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Humans; Inflammation; Lung; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Pneumocystis carinii; Pneumocystis Infections; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein D; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2004 |
Increased nitrotyrosine production in patients undergoing abdominal aortic aneurysm repair.
Topics: Adult; Aged; Aortic Aneurysm, Abdominal; Biomarkers; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Tyrosine | 2004 |
Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Confocal; Neurons; Nitric Oxide; Nitric Oxide Synthase; Plaque, Amyloid; Tyrosine | 2004 |
Scavenging of reactive nitrogen species by oxygenated hemoglobin: globin radicals and nitrotyrosines distinguish nitrite from nitric oxide reaction.
Topics: Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Hemoglobins; Humans; Methemoglobin; Models, Chemical; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxidative Stress; Oxyhemoglobins; Reactive Nitrogen Species; Spectrometry, Mass, Electrospray Ionization; Spin Trapping; Tyrosine | 2004 |
Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.
Topics: Animals; Brain Chemistry; Citrulline; Dopamine; Enzyme Inhibitors; Fever; Male; Malonates; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Rats; Serotonin; Serotonin Agents; Thiourea; Tyrosine | 2005 |
Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats.
Topics: Animals; Body Weight; Catalysis; Cisplatin; Glomerular Mesangium; Kidney Diseases; Kidney Tubules; Male; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Tyrosine; Urine | 2004 |
Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Immunoenzyme Techniques; Incidence; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Precancerous Conditions; Tyrosine | 2004 |
N-acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury.
Topics: Acetylcysteine; Animals; Female; Lung; Malondialdehyde; Microscopy; Oleic Acid; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2004 |
Hyperoxia attenuated nitrotyrosine concentration in the lung tissue of rats with experimental pneumonia.
Topics: Animals; Carrageenan; Hyperoxia; Lung; Male; Pneumonia; Rats; Rats, Wistar; Tyrosine | 2004 |
Beta2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle.
Topics: Adrenergic beta-Agonists; Aging; Animals; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Fractionation; Fenoterol; Kinetics; Male; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Relaxation; Muscle, Skeletal; Myosin Heavy Chains; Protein Isoforms; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Fluorescence; Tyrosine | 2005 |
Peroxynitrite scavenging mode of alaternin isolated from Cassia tora.
Topics: Cassia; Emodin; Free Radical Scavengers; Glucosides; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Plants, Medicinal; Pyrones; Rhodamines; Serum Albumin, Bovine; Spectrophotometry; Superoxides; Tyrosine | 2004 |
Peroxynitrite decomposition catalyst, iron metalloporphyrin, reduces quinolinate-induced neurotoxicity in rats.
Topics: Animals; Antioxidants; Brain Diseases; Corpus Striatum; Iron; Male; Metalloporphyrins; Neurotoxins; Nitrogen; Oxidative Stress; Peroxynitrous Acid; Quinolinic Acid; Rats; Rats, Wistar; Tyrosine | 2004 |
Inhibition of iNOS augments cardiovascular action of noradrenaline in streptozotocin-induced diabetes.
Topics: Acute Disease; Adrenergic beta-Antagonists; Amidines; Animals; Benzylamines; Blood Pressure; Depression, Chemical; Diabetes Mellitus, Experimental; Male; Myocardial Contraction; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Propranolol; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine; Vascular Resistance | 2004 |
Abnormal cardiac wall motion and early matrix metalloproteinase activity.
Topics: Animals; Collagen; Dansyl Compounds; Dogs; Female; Fibrinolysin; Heart; Heart Rate; Indicators and Reagents; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardial Contraction; Myocardium; Nitrogen; Pacemaker, Artificial; Peroxidase; Tyrosine | 2005 |
Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Benzothiadiazines; Cells, Cultured; Cyclic GMP; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Kainic Acid; Microtubule-Associated Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Proton Pumps; Quinoxalines; Rats; Receptors, AMPA; Tyrosine | 2004 |
Anomalous pH-dependence of the activity of human matrilysin (matrix metalloproteinase-7) as revealed by nitration and amination of its tyrosine residues.
Topics: 2,4-Dinitrophenol; Amination; Amino Acids, Acidic; Azo Compounds; Catalysis; Circular Dichroism; Collagen; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Matrix Metalloproteinase 7; Mutagenesis, Site-Directed; Oligopeptides; Plasminogen; Recombinant Proteins; Transaminases; Tyrosine | 2005 |
Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice.
Topics: Acetylcholine; Anemia, Sickle Cell; Animals; Cell Adhesion; Cyclooxygenase 2; Endothelium, Vascular; Enzyme Inhibitors; Female; Fetal Hemoglobin; Hemodynamics; Hemoglobin, Sickle; Hemolysis; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microcirculation; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Tyrosine; Vasodilation; Vasodilator Agents | 2004 |
Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats.
Topics: Animals; Antioxidants; Bleomycin; Drug Therapy, Combination; Glutathione Peroxidase; Guanidines; Male; Malondialdehyde; Nitric Oxide; Peroxidase; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thioglycolates; Thiophenes; Tyrosine | 2004 |
Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Topics: Animals; Benzyl Compounds; Biomarkers; Caspase 3; Caspase Inhibitors; Cysteine Proteinase Inhibitors; Hydrocarbons, Fluorinated; Immunohistochemistry; In Vitro Techniques; Intercellular Adhesion Molecule-1; Kidney; Kidney Function Tests; Male; Malondialdehyde; Myocardium; Nitric Oxide; Oligopeptides; Organ Size; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Serpins; Tyrosine; Viral Proteins | 2004 |
Deletion of p66shc gene protects against age-related endothelial dysfunction.
Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Aorta; Endothelium, Vascular; Isometric Contraction; Longevity; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Proteins; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxide Dismutase; Tyrosine; Vasoconstriction | 2004 |
Arsenic exposure exacerbates atherosclerotic plaque formation and increases nitrotyrosine and leukotriene biosynthesis.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arsenites; Arteriosclerosis; Enzyme Inhibitors; Female; Leukotriene E4; Male; Mice; Muscle, Smooth, Vascular; Sodium Compounds; Tyrosine | 2004 |
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
Topics: Animals; Antioxidants; Disease Models, Animal; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Transgenic; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-myc; Transforming Growth Factor alpha; Tyrosine; Vitamin E | 2004 |
Protein nitration in chronic sinusitis and nasal polyposis: role of eosinophils.
Topics: Adult; Aged; Chronic Disease; Eosinophil Peroxidase; Eosinophils; Female; Humans; Male; Middle Aged; Nasal Polyps; Sinusitis; Tyrosine | 2004 |
Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy.
Topics: Animals; Animals, Newborn; Antioxidants; Glutathione; Isoenzymes; Malondialdehyde; Metalloporphyrins; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxidation-Reduction; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Vessels; Salicylates; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration.
Topics: Animals; Functional Laterality; Guanidines; Immunohistochemistry; Inflammation; Interneurons; Male; Motor Activity; N-Methylaspartate; NADPH Dehydrogenase; Neostriatum; Nerve Degeneration; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2004 |
Differential effects of exercise on aortic mitochondria.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria; Mitochondrial ADP, ATP Translocases; Oxidative Stress; Physical Exertion; Risk Factors; Tyrosine | 2005 |
The role of poly(ADP-ribose) synthetase inhibition on the intestinal mucosal barrier after thermal injury.
Topics: Animals; Bacterial Translocation; Benzamides; Burns; Enzyme Inhibitors; Intestinal Mucosa; Intestine, Small; Liver; Lymph Nodes; Malondialdehyde; Mesentery; Poly(ADP-ribose) Polymerase Inhibitors; Random Allocation; Rats; Rats, Wistar; Spleen; Tyrosine | 2004 |
Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch.
Topics: Animals; Carcinogens; Cell Survival; Cells, Cultured; Chromatin; Cricetinae; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Oxidative Stress; Peroxynitrous Acid; Tobacco, Smokeless; Tyrosine | 2004 |
Trouble with the analysis of nitrite, nitrate, S-nitrosothiols and 3-nitrotyrosine: freezing-induced artifacts?
Topics: Artifacts; Freezing; Gas Chromatography-Mass Spectrometry; Nitrates; Nitric Oxide; Nitrites; S-Nitrosothiols; Tyrosine | 2004 |
Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion.
Topics: Animals; Creatinine; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-6; Kidney; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Nephritis; P-Selectin; Reperfusion Injury; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.
Topics: Amino Acid Sequence; Animals; Antioxidants; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Chlorine; Cholesterol; Cricetinae; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Peroxide; Hydrophobic and Hydrophilic Interactions; Nitrates; Nitrogen; Oxidation-Reduction; Peptides; Peroxidase; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Immunogenicity of autologous IgG bearing the inflammation-associated marker 3-nitrotyrosine.
Topics: Animals; Antibodies; DNA; Immunoglobulin G; Mice; Tyrosine | 2005 |
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats.
Topics: Acetylcarnitine; Animals; Biomarkers; Brain; Carnitine; Guanine; Male; Malondialdehyde; Motor Activity; Oxidative Stress; Rats; Rats, Inbred F344; Tyrosine | 2004 |
Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress.
Topics: Animals; Antioxidants; Blood Pressure; Brain Chemistry; Cattle; Cyclic N-Oxides; Heart Rate; Hypertension; Infusion Pumps, Implantable; Male; Medulla Oblongata; Mice; Microdialysis; Microinjections; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Oxidative Stress; Random Allocation; Rats; Rats, Inbred WKY; Recombinant Fusion Proteins; Spin Labels; Superoxides; Sympathetic Nervous System; Transduction, Genetic; Tyrosine; Vasomotor System | 2005 |
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.
Topics: Aging; Animals; Apoptosis; Apoptosis Inducing Factor; Autophagy; Brain Injuries; Calpain; Caspase 3; Caspases; Cell Death; Cytochromes c; Disease Models, Animal; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; Necrosis; Neurons; Protein Transport; Tyrosine | 2005 |
Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein-tyrosine nitration to protein-cysteine nitrosation.
Topics: Albumins; Animals; Antioxidants; Catalysis; Cyclic N-Oxides; Cysteine; Electrochemistry; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Immunoblotting; Immunohistochemistry; Inflammation; Macrophages; Mice; Models, Biological; Models, Chemical; Nitric Oxide; Nitrites; Nitrogen; Oxygen; Peroxynitrous Acid; Serum Albumin, Bovine; Spin Labels; Time Factors; Tyrosine | 2005 |
Absence of host tumor necrosis factor receptor 1 attenuates manifestations of idiopathic pneumonia syndrome.
Topics: Animals; Apoptosis; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Chemokines; Cytokines; Flow Cytometry; Lung Diseases, Interstitial; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide; Receptors, Tumor Necrosis Factor, Type I; Survival Rate; Tyrosine | 2005 |
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst.
Topics: Animals; Blood Glucose; Creatine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Metalloporphyrins; Mice; Mice, Inbred NOD; Neural Conduction; Neurons, Afferent; Oxidative Stress; Peroxynitrous Acid; Phosphocreatine; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reactive Nitrogen Species; Sciatic Nerve; Tyrosine; Weight Gain | 2005 |
Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells.
Topics: Acetylcysteine; Amlodipine; Animals; Biomarkers; Body Weight; Calcium; Dietary Supplements; Hydrogen Peroxide; Hyperaldosteronism; Leukocytes, Mononuclear; Magnesium; Male; Oxidation-Reduction; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Tyrosine; Vasculitis | 2005 |
Endothelial cell activation in patients with decompensated heart failure.
Topics: Adult; Aged; Brachial Artery; Cardiotonic Agents; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Dinoprostone; Endothelium, Vascular; Enzyme Induction; Female; Heart Failure; Humans; Male; Membrane Proteins; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Tyrosine; Vasodilation; Veins | 2005 |
Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor.
Topics: Alanine Transaminase; Animals; Arginine; Aspartate Aminotransferases; Enzyme Inhibitors; Immunohistochemistry; L-Lactate Dehydrogenase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Staining and Labeling; Tyrosine | 2004 |
Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Astrocytes; Cell Count; Cell Death; Central Nervous System Diseases; Epilepsy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Growth Substances; Guanine; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Interleukins; Kainic Acid; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Neurofibrillary Tangles; Staining and Labeling; Tyrosine | 2005 |
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.
Topics: Aldehyde Reductase; Animals; Aorta; Arterioles; Cattle; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fructose; Imidazolidines; Male; Motor Neurons; Neural Conduction; Neurons, Afferent; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Tyrosine | 2005 |
Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms.
Topics: Animals; Blood Pressure; Blotting, Western; Cardiovascular Physiological Phenomena; Cholinesterase Inhibitors; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Heart Rate; Male; Medulla Oblongata; Mevinphos; Microinjections; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Spectrum Analysis; Superoxides; Time Factors; Tyrosine | 2005 |
Role of metallothionein in antigen-related airway inflammation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antigens; Bronchitis; Bronchoalveolar Lavage Fluid; Chemokines; Cytokines; Deoxyguanosine; Immunohistochemistry; Metallothionein; Mice; Trachea; Tyrosine | 2005 |
Effect of methylguanidine in a model of septic shock induced by LPS.
Topics: Animals; Cell Line; Cell Survival; Disease Models, Animal; Lipopolysaccharides; Lung; Macrophages; Male; Methylguanidine; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Shock, Septic; Survival Rate; Tyrosine | 2004 |
Plasma nitrotyrosine in reversible myocardial ischaemia.
Topics: Adult; Aged; Exercise Test; Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Peroxynitrous Acid; Tyrosine | 2005 |
Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Cell Line; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Protein Processing, Post-Translational; Proteins; Tyrosine; Vehicle Emissions | 2005 |
Peroxynitrite-mediated oxidation of the C85S/C152E mutant of dihydrofolate reductase from Escherichia coli: functional and structural effects.
Topics: Blotting, Western; Calorimetry, Differential Scanning; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine; Cystine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoblotting; Mutation; Oxidative Stress; Oxygen; Peroxynitrous Acid; Reactive Oxygen Species; Spectrometry, Fluorescence; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Time Factors; Tryptophan; Tyrosine | 2005 |
Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2.
Topics: Acetylcarnitine; Animals; Astrocytes; Blotting, Western; Cell Line; Cell Nucleus; Chaperonin 60; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epistasis, Genetic; Gene Expression Regulation; Glucose Oxidase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Interferon-gamma; Lipopolysaccharides; NF-E2-Related Factor 2; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nootropic Agents; Oxidative Stress; Protoporphyrins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trans-Activators; Tyrosine | 2005 |
Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Cell Count; Disease Models, Animal; Disease Progression; Gliosis; Lumbosacral Region; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; PPAR gamma; Psychomotor Performance; Spinal Cord; Superoxide Dismutase; Survival Rate; Thiazolidinediones; Tyrosine; Weight Loss | 2005 |
Oxidative injury by peroxynitrite in neural and vascular tissue of the lateral geniculate nucleus in experimental glaucoma.
Topics: Animals; Endothelium, Vascular; Geniculate Bodies; Glaucoma; Immunohistochemistry; Macaca fascicularis; Macaca mulatta; Nerve Degeneration; Neurons; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2005 |
3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line.
Topics: Antiviral Agents; Bronchi; Cell Line; Chemokine CCL5; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Interferon Regulatory Factor-3; Interferon-gamma; Interleukin-8; Microtubules; Nitrogen; Nitrogen Dioxide; Respiratory Mucosa; Respiratory Syncytial Virus Infections; Signal Transduction; Transcription Factors; Tubulin; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells.
Topics: Age Factors; Animals; Antigens, Differentiation; Brain; Caspase 3; Caspases; Cell Count; Dentate Gyrus; Disease Models, Animal; Female; Functional Laterality; Lateral Ventricles; Male; Myelin Sheath; Particle Accelerators; Radiation Injuries, Experimental; Radiation Tolerance; Rats; Rats, Wistar; Stem Cells; Tumor Suppressor Protein p53; Tyrosine | 2005 |
Peroxynitrite and fibrinolytic system: the effect of peroxynitrite on plasmin activity.
Topics: Blotting, Western; Chromatography, Affinity; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Fibrinolysin; Glutathione; Inhibitory Concentration 50; Oxidants; Peroxynitrous Acid; Plasminogen; Spectrophotometry; Streptokinase; Time Factors; Tyrosine | 2004 |
Astroglial nitration after postnatal excitotoxic damage: correlation with nitric oxide sources, cytoskeletal, apoptotic and antioxidant proteins.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cytoskeletal Proteins; Disease Models, Animal; Female; Male; Metallothionein; Nerve Tissue Proteins; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Long-Evans; Superoxide Dismutase; Tyrosine | 2005 |
NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity.
Topics: Aldehydes; Animals; Anti-Bacterial Agents; Auditory Threshold; Benzimidazoles; Blotting, Western; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Death; Cell Fractionation; Cochlea; Cyclooxygenase Inhibitors; DNA Replication Timing; Drosophila Proteins; Drug Administration Schedule; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Activation; Hair Cells, Auditory; Hydroxybenzoates; Immunohistochemistry; Immunoprecipitation; Iron Chelating Agents; Kanamycin; Male; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Molecular Chaperones; Nerve Tissue Proteins; NF-kappa B; Phosphorylation; Protective Agents; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salicylates; Signal Transduction; Synaptotagmin I; Synaptotagmins; Time Factors; Tyrosine | 2005 |
Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats.
Topics: Animals; Animals, Newborn; Biotin; Brain Chemistry; Cytochromes c; Female; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Tyrosine | 2005 |
Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Biopsy; Bleomycin; Epoxy Compounds; Immunoenzyme Techniques; Instillation, Drug; Male; Mice; Nitric Oxide Synthase; Peroxidase; Poly(ADP-ribose) Polymerases; Prostaglandin D2; Pulmonary Fibrosis; Random Allocation; Rosiglitazone; Thiazolidinediones; Tyrosine; Weight Loss | 2005 |
Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload.
Topics: Animals; Aorta; Apoptosis; Blood Pressure; Cell Size; Chronic Disease; Constriction, Pathologic; Drug Evaluation, Preclinical; Eplerenone; Fibrosis; Heart Failure; Hypertrophy, Left Ventricular; Intercellular Adhesion Molecule-1; Ligation; Male; Matrix Metalloproteinases; Mice; Mineralocorticoid Receptor Antagonists; Myocarditis; Myocardium; Myocytes, Cardiac; Oxidative Stress; Pressure; Random Allocation; Receptors, Mineralocorticoid; Spironolactone; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tyrosine | 2005 |
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.
Topics: Animals; Antioxidants; Biopterins; Diabetic Nephropathies; Gene Expression Regulation, Enzymologic; Kidney Glomerulus; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2005 |
Effects of antioxidant vitamin supplements on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Ascorbic Acid; Deoxyguanosine; Dietary Supplements; Disease Models, Animal; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Stomach Neoplasms; Thiobarbituric Acid Reactive Substances; Tyrosine; Vitamin E; Vitamins | 2005 |
Immunohistochemical demonstration of nitrotyrosine, a biomarker of oxidative stress, in islet cells of the NOD mouse.
Topics: Animals; Biomarkers; Cyclophosphamide; Diabetes Mellitus, Experimental; Female; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans; Macrophages; Mice; Mice, Inbred NOD; Oxidative Stress; Time Factors; Tyrosine | 2004 |
Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum.
Topics: Animals; Brain Ischemia; Corpus Callosum; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Glutathione; Immunohistochemistry; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Microglia; Microinjections; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organic Chemicals; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2005 |
Increased nitration of sarcoplasmic reticulum Ca2+-ATPase in human heart failure.
Topics: Adolescent; Adult; Blotting, Western; Calcium-Transporting ATPases; Female; Heart Failure; Heart Ventricles; Humans; Isoenzymes; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Phosphorylation; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2005 |
Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.
Topics: Animals; Brain; Brain Injuries; Electron Spin Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Tyrosine | 2005 |
Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animal Feed; Animals; Antioxidants; Astrocytes; Blotting, Western; Body Weight; Chromatography, High Pressure Liquid; Dietary Fats; Disease Susceptibility; Dopamine; Dopamine Agents; Glial Fibrillary Acidic Protein; Immunoblotting; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; MPTP Poisoning; Neurons; Neurotoxicity Syndromes; Nitrates; Nitric Oxide; Nitrites; Obesity; Oxidative Stress; Phosphorylation; Substantia Nigra; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2005 |
Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development.
Topics: Animals; Animals, Newborn; Antibodies; Apoptosis; Caspase 3; Caspases; Cell Proliferation; Female; Humans; Lung; Mice; Oxidative Stress; Oxygen; Pulmonary Alveoli; Tyrosine; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2005 |
Copper-mediated intra-ligand oxygen transfer in gas-phase complexes with 3-nitrotyrosine.
Topics: Carbonic Acid; Copper; Deuterium Exchange Measurement; Gases; Ions; Ligands; Macromolecular Substances; Molecular Structure; Oxygen; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin.
Topics: Animals; Apoptosis; DNA; Enzyme Activation; Free Radical Scavengers; I-kappa B Proteins; Lipid Peroxidation; Male; Melatonin; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tyrosine | 2005 |
Facilitated nitration and oxidation of LDL in cigarette smokers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Female; Guanine; Humans; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Smoking; Thiobarbituric Acid Reactive Substances; Tyrosine; Vitamin E | 2005 |
Functional and molecular defects of pancreatic islets in human type 2 diabetes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; AMP-Activated Protein Kinases; Deoxyguanosine; Diabetes Mellitus, Type 2; Female; Gene Expression; Glucose; Glutathione; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Multienzyme Complexes; Oxidative Stress; Protein Serine-Threonine Kinases; Time Factors; Tyrosine | 2005 |
Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and the formation of cytotoxic nitrogen-related oxidants.
Topics: Animals; Aqueous Humor; Cornea; Immunohistochemistry; Lipid Peroxidation; Malondialdehyde; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Rabbits; Reactive Nitrogen Species; Tyrosine; Ultraviolet Rays | 2005 |
Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane.
Topics: Animals; Azoxymethane; Carcinogens; Cocarcinogenesis; Colitis; Colonic Diseases; Colonic Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Tyrosine; Ulcer | 2005 |
Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632.
Topics: Amides; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Lung; Male; Malondialdehyde; Nitrates; Nitrites; Oleic Acid; Peroxidase; Protein Serine-Threonine Kinases; Pyridines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; Tyrosine; Up-Regulation | 2005 |
Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function.
Topics: Aged; Antioxidants; Ascorbic Acid; Cartilage, Articular; Cell Division; Cells, Cultured; Cellular Senescence; Chondrocytes; Disease Progression; DNA Replication; Female; Free Radicals; Genomic Instability; Glycosaminoglycans; Humans; Middle Aged; Organ Culture Techniques; Osteoarthritis, Knee; Oxidative Stress; Reactive Oxygen Species; Telomere; Tyrosine | 2005 |
Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats.
Topics: Angiotensin II; Anilides; Animals; Aorta, Thoracic; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Fulvestrant; Genistein; Hypertension; Male; Membrane Transport Proteins; NADPH Dehydrogenase; NADPH Oxidases; Phosphoproteins; PPAR gamma; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Signal Transduction; Stroke; Superoxides; Tyrosine; Vasoconstrictor Agents | 2004 |
Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse.
Topics: Animals; Apoptosis; Arthritis, Experimental; Cartilage, Articular; Chemokines; Chondrocytes; Cytokines; Disease Models, Animal; Erythropoietin; Hematinics; Injections, Subcutaneous; Mice; Mice, Inbred DBA; Neutrophil Infiltration; Poly(ADP-ribose) Polymerases; Tyrosine | 2005 |
Evaluation of nitrosative and oxidative stress in Behçet disease.
Topics: Adult; Antioxidants; Behcet Syndrome; C-Reactive Protein; Case-Control Studies; Female; Humans; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2005 |
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Chronic Disease; Collagen; Humans; Hypertension; Kidney; Membrane Glycoproteins; Mice; Mice, Transgenic; Myocardium; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Reactive Oxygen Species; Renin; Tyrosine | 2005 |
The role of nitric oxide synthases and nitrotyrosine in retinoblastoma.
Topics: Child, Preschool; Cohort Studies; Female; Humans; Immunoenzyme Techniques; Infant; Male; Neoplasm Invasiveness; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Retinal Neoplasms; Retinoblastoma; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2005 |
Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration.
Topics: Animals; Blood Urea Nitrogen; Chromium; Free Radical Scavengers; Glycyrrhiza; Kidney; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2005 |
Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment.
Topics: Aldehydes; Animals; Antineoplastic Agents; Cisplatin; Cochlea; Free Radicals; Hair Cells, Auditory, Outer; Hydroxyl Radical; Immunohistochemistry; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Spiral Ganglion; Tyrosine | 2004 |
Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat.
Topics: Animals; Antioxidants; Hypertension, Renal; Immunohistochemistry; Kidney Tubules, Proximal; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tyrosine | 2005 |
Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Apoptosis; Astrocytes; Caspase 3; Cell Count; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Fibroblast Growth Factor 1; Fluorescent Antibody Technique; Free Radical Scavengers; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Metalloporphyrins; Mice; Mice, Transgenic; Motor Neurons; Nerve Growth Factor; Protein-Tyrosine Kinases; Pyrimidines; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Nerve Growth Factor; RNA, Messenger; Spinal Cord; Superoxide Dismutase; Tyrosine; Urea | 2005 |
Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Cholesterol; Dopamine; Dopamine Agents; Homovanillic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Microglia; Neostriatum; Nitrates; Nitric Oxide; Oxidants; Simvastatin; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2005 |
Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia.
Topics: Adenosine Triphosphate; Adult; Animals; Antibodies, Monoclonal; Arteries; Case-Control Studies; Cattle; Cell Survival; Cells, Cultured; Culture Media; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Humans; L-Lactate Dehydrogenase; Middle Aged; Myometrium; Oxidative Stress; Phenanthrenes; Plasma; Poly(ADP-ribose) Polymerases; Pre-Eclampsia; Pregnancy; Reactive Oxygen Species; Time Factors; Tyrosine | 2005 |
Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease.
Topics: Acetylcholine; Afferent Pathways; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Denervation; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Presynaptic Terminals; Serotonin; Superoxide Dismutase; Tyrosine; Wallerian Degeneration | 2005 |
Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium.
Topics: Adult; Blotting, Western; Epithelial Cells; Epithelium, Corneal; Eye Proteins; Humans; Immunohistochemistry; Middle Aged; Nitric Oxide; Oxidants; Peroxynitrous Acid; Tissue Culture Techniques; Tyrosine | 2005 |
Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Catalysis; Cyclosporine; Gene Expression; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Malondialdehyde; Metalloporphyrins; Myocardium; Neutrophils; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Rats, Wistar; Tyrosine | 2005 |
Role of oxidative stress in the pathogenesis of septic ileus in mice.
Topics: Aldehydes; Animals; Antioxidants; Catalase; Disease Models, Animal; Gastric Emptying; Gastrointestinal Transit; Ileus; Immunohistochemistry; Intestinal Mucosa; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Sepsis; Superoxide Dismutase; Tyrosine | 2005 |
Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats.
Topics: Acute Disease; Animals; Animals, Genetically Modified; Antioxidants; Blood Pressure; Cyclic N-Oxides; Dinoprost; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension, Renal; Kidney; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renal Circulation; Renin; Sodium; Spin Labels; Tyrosine | 2005 |
Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction.
Topics: alpha-Synuclein; Animals; Blotting, Western; Chronic Disease; Dopamine; Horse Diseases; Horses; Immunohistochemistry; Nerve Degeneration; Nerve Tissue Proteins; Nitrogen; Oxidative Stress; Pituitary ACTH Hypersecretion; Pituitary Gland; Synucleins; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with vasomotor rhinitis.
Topics: Adult; Cavernous Sinus; Female; Humans; Immunohistochemistry; Male; Muscle, Smooth; Nitric Oxide; Peroxynitrous Acid; Respiratory Mucosa; Rhinitis, Vasomotor; Rhinomanometry; Tyrosine | 2005 |
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.
Topics: Amyloid beta-Peptides; Animals; Biomarkers; Brain; Disease Models, Animal; Encephalitis; Genetic Predisposition to Disease; Gliosis; Humans; Injections, Intraventricular; Mice; Mice, Knockout; Mice, Transgenic; Nerve Degeneration; Nerve Growth Factors; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine | 2005 |
Activation of caspase-3 is associated with oxidative stress in the hydropic guinea pig cochlea.
Topics: Animals; Apoptosis; Audiometry; Caspase 3; Caspases; Cochlea; Cochlear Diseases; Dinoprost; Disease Models, Animal; Endolymphatic Hydrops; Enzyme Activation; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Immunohistochemistry; Meniere Disease; Oxidative Stress; Spiral Ganglion; Staining and Labeling; Tyrosine | 2005 |
Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Case-Control Studies; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Endothelial Cells; Enzyme Activation; Estradiol; Female; Humans; Male; Mice; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2005 |
Increased matrix metalloproteinases 2 and 9 in placenta of diabetic rats at midgestation.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Gestational Age; Immunohistochemistry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitrates; Nitrites; Placenta; Pregnancy; Rats; Rats, Wistar; Tyrosine | 2005 |
Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers.
Topics: Adenocarcinoma; Animals; Arginase; Arginine; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Humans; Interferon-gamma; Lymphocyte Count; Lymphocytes, Tumor-Infiltrating; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase; Organ Culture Techniques; Prostatic Neoplasms; T-Lymphocyte Subsets; Tyrosine | 2005 |
Comparison of spectrophotometric, HPLC and chemiluminescence methods for 3-nitrotyrosine and peroxynitrite interaction.
Topics: Chromatography, High Pressure Liquid; Hypochlorous Acid; Luminescent Measurements; Peroxynitrous Acid; Spectrophotometry, Ultraviolet; Tyrosine | 2005 |
Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells.
Topics: Animals; Arsenites; CHO Cells; Cricetinae; DNA Damage; DNA, Mitochondrial; Humans; Hybrid Cells; Intracellular Membranes; Membrane Potentials; Mitochondria; Mutagenicity Tests; Peroxynitrous Acid; Proteins; Reactive Oxygen Species; Sodium Compounds; Tyrosine | 2005 |
Remnant liver injury after hepatectomy with the pringle maneuver and its inhibition by an iNOS inhibitor (ONO-1714) in a pig model.
Topics: Amidines; Animals; Enzyme Inhibitors; Female; Hepatectomy; Heterocyclic Compounds, 2-Ring; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Liver; Liver Circulation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Swine; Tyrosine | 2005 |
Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Synergism; Enzyme Inhibitors; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Necrosis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Proteins; Pyrazoles; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2005 |
Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival.
Topics: Adenocarcinoma; Adult; Aged; Apoptosis; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Stomach Neoplasms; Survival Analysis; Tyrosine | 2005 |
Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry.
Topics: Aging; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Molecular Sequence Data; Muscle Proteins; Muscle, Skeletal; Nanotechnology; Nitrates; Proteome; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.
Topics: Aldehydes; Analysis of Variance; Animals; Cell Count; Dopamine; Drug Administration Schedule; Ferritins; Herbicides; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Oxidative Stress; Paraquat; Promoter Regions, Genetic; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chick Embryo; Chondrocytes; Collagen Type X; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cysteine; Gene Expression; Growth Plate; Guanylate Cyclase; Immunohistochemistry; Isoenzymes; Luciferases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Promoter Regions, Genetic; Recombinant Fusion Proteins; S-Nitrosoglutathione; S-Nitrosothiols; Sternum; Transfection; Tretinoin; Tyrosine | 2005 |
Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration.
Topics: Animals; Body Weight; Cardiomegaly; Cytochromes c; Heart Ventricles; Heat-Shock Proteins; Iron Deficiencies; Male; Microscopy, Electron; Mitochondria, Heart; Myocardium; Myocytes, Cardiac; Nitric Oxide Synthase; Organ Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine | 2005 |
Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity.
Topics: Animals; Beverages; Camellia sinensis; Cattle; Cell Line; Cell Shape; Cell Survival; Drug Evaluation, Preclinical; Flavonoids; Free Radical Scavengers; Humans; Ilex paraguariensis; Macrophages; Mice; Peroxynitrous Acid; Phenols; Plant Extracts; Polyphenols; Serum Albumin, Bovine; Tea; Tyrosine; Wine | 2005 |
The effects of nitric oxide synthesis on the Na+ ,K(+)-ATPase activity in guinea pig kidney exposed to lipopolysaccharides.
Topics: Animals; Free Radicals; Guinea Pigs; Kidney; Lipopolysaccharides; Nephritis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Reactive Nitrogen Species; Regression Analysis; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2005 |
The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Apolipoproteins E; Arteriosclerosis; Body Weight; Collagen; Female; Mice; Mice, Knockout; Tyrosine; Uremia | 2005 |
Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus.
Topics: Adult; Aged; Aged, 80 and over; Barrett Esophagus; Esophagitis; Female; Free Radicals; Gastroesophageal Reflux; Glutathione; Humans; Male; Middle Aged; Oxidoreductases; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2005 |
Characterization of nitroproteome in neuron-like PC12 cells differentiated with nerve growth factor: identification of two nitration sites in alpha-tubulin.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Differentiation; Electrophoresis, Gel, Two-Dimensional; Molecular Sequence Data; Nerve Growth Factor; Nitric Oxide; PC12 Cells; Protein Conformation; Proteome; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tubulin; Tyrosine | 2005 |
Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury.
Topics: Adenoviridae; Aldehydes; Animals; Blotting, Western; Gene Transfer Techniques; Hepatocytes; I-kappa B Proteins; Kupffer Cells; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Caffeic acid phenethyl ester (CAPE) supplemented St. Thomas' hospital cardioplegic solution improves the antioxidant defense system of rat myocardium during ischemia-reperfusion injury.
Topics: Animals; Antioxidants; Caffeic Acids; Cardioplegic Solutions; Catalase; Free Radical Scavengers; Heart; In Vitro Techniques; Male; Malondialdehyde; Myocardial Reperfusion Injury; Peroxidase; Phenylethyl Alcohol; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2005 |
Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.
Topics: Animals; Apoptosis; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Female; Genetic Vectors; Glutathione Peroxidase; Heterozygote; Immunohistochemistry; Integrases; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Genetic; Myocardium; Oocytes; Oxidative Stress; Oxygen; Phenotype; Promoter Regions, Genetic; Recombination, Genetic; Ribonucleases; RNA; RNA, Messenger; Signal Transduction; Stem Cells; Superoxide Dismutase; Tyrosine | 2005 |
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bezafibrate; Body Weight; Chromans; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Hypolipidemic Agents; Immunohistochemistry; Inflammation; Injections, Intraperitoneal; Ligands; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Organ Size; Peroxisome Proliferator-Activated Receptors; Sulfonamides; Temperature; Thiazolidinediones; Troglitazone; Tyrosine; Vasodilator Agents | 2005 |
Thalidomide treatment reduces colon injury induced by experimental colitis.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Immunohistochemistry; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-1; Mice; Neutrophils; Peroxidase; Poly Adenosine Diphosphate Ribose; Thalidomide; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A | 2005 |
15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism.
Topics: Acetates; Animals; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Experimental; Female; Gestational Age; Lipid Metabolism; Nitrates; Nitrites; Peroxynitrous Acid; Placenta; PPAR gamma; Pregnancy; Prostaglandin D2; Rats; Rats, Wistar; Streptozocin; Tyrosine | 2005 |
Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Kidney; Male; Molsidomine; Nitrates; Nitric Oxide Donors; Nitrites; Oxidative Stress; Oxidoreductases; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Superoxides; Tyrosine | 2005 |
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Parkinson Disease; Peptide Fragments; Peroxynitrous Acid; Recombinant Proteins; Solubility; Synucleins; Tyrosine | 2005 |
[Vascular damage in chronic renal failure. The increase of vascular nitrotyrosine and cytochines accumulation is accompanied by an increase of endothelial nitric oxide synthase (eNOS) expression].
Topics: Blood Vessels; Cytokines; Endothelium; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Tyrosine; Vascular Diseases | 2005 |
Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia.
Topics: Acetophenones; Aconitate Hydratase; Aldehydes; Animals; Antioxidants; Blood Pressure; Body Weight; Creatine; Cyclic GMP; Cyclic N-Oxides; Drinking; Eating; Hypertension; Isoprostanes; Kidney; Leptin; Male; Malondialdehyde; Natriuresis; Nitric Oxide; Rats; Rats, Wistar; Reactive Nitrogen Species; Sodium; Spin Labels; Tyrosine | 2005 |
Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Diabetes Complications; Gene Expression; Heart Diseases; Male; Metallothionein; Mice; Mice, Transgenic; Nitrosation; Superoxides; Tyrosine | 2005 |
Reduced development of experimental periodontitis by treatment with M40403, a superoxide dismutase mimetic.
Topics: Alveolar Bone Loss; Animals; Capillary Permeability; Ligation; Lipid Peroxidation; Male; Manganese; Neutrophil Infiltration; Organometallic Compounds; Periodontitis; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2005 |
Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging.
Topics: Aging; Animals; Blotting, Western; Brain; Caveolin 1; Caveolins; Chromatography, High Pressure Liquid; Immunoprecipitation; Mass Spectrometry; Membrane Proteins; Rats; Rats, Inbred BN; Rats, Inbred F344; Tubulin; Tyrosine | 2005 |
Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport.
Topics: Animals; Cell Respiration; Disease Models, Animal; Electron Transport Complex IV; Male; Mice; Mice, Knockout; Myocardial Ischemia; NADH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type III; Oximetry; Oxygen; Oxygen Consumption; Tyrosine; Up-Regulation | 2005 |
In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes.
Topics: Animals; Chromatography, High Pressure Liquid; Cinnamomum zeylanicum; Eugenol; Lipid Peroxidation; Microsomes, Liver; Nitrates; Oils, Volatile; Oxidation-Reduction; Peroxynitrous Acid; Rats; Tyrosine | 2005 |
Pulmonary oxidant stress in murine sepsis is due to inflammatory cell nitric oxide.
Topics: Analysis of Variance; Animals; Bone Marrow Transplantation; Chimera; Dinoprost; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Random Allocation; Respiratory Distress Syndrome; Sepsis; Tyrosine | 2005 |
Correction of endothelial dysfunction by tetrahydrobiopterin: new hope for the treatment of arterial hypertension?
Topics: Angiotensin II; Animals; Antioxidants; Biopterins; Cardiomegaly; Endothelium, Vascular; Hypertension; Immunohistochemistry; Male; Myocardium; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Tyrosine; Up-Regulation | 2005 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NADPH Oxidases; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Time Factors; Tyrosine; Up-Regulation | 2005 |
Abnormalities in nitric oxide and its derivatives in lung cancer.
Topics: Aged; Breath Tests; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Proteins; Proteomics; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2005 |
TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.
Topics: Aged; Cyclooxygenase 2; Female; Genes, p53; Genes, ras; Humans; Immunohistochemistry; Lung Neoplasms; Male; Membrane Proteins; Middle Aged; Mutation; Prostaglandin-Endoperoxide Synthases; Smoking; Tumor Suppressor Protein p53; Tyrosine | 2005 |
Post-exposure treatment attenuates noise-induced hearing loss.
Topics: Aldehydes; Animals; Cochlea; Guinea Pigs; Hearing Loss, Noise-Induced; Immunohistochemistry; Male; Reactive Oxygen Species; Sound; Time Factors; Tyrosine | 2005 |
Exposure to ethanol induces oxidative damage in the pituitary gland.
Topics: Aldehydes; Animals; Apoptosis; Central Nervous System Depressants; Dinitrophenols; Ethanol; Follicle Stimulating Hormone; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Lipid Peroxidation; Luteinizing Hormone; Male; Nucleic Acids; Nucleosides; Oxidation-Reduction; Oxidative Stress; Pituitary Gland; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Testosterone; Tyrosine | 2005 |
Peroxynitrite like Pan?
Topics: Biomarkers; Cells, Cultured; Heart Failure; Humans; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Tyrosine | 2005 |
Protective effect of trapidil against oxidative organ damage in burn injury.
Topics: Animals; Burns; Lipid Peroxidation; Malondialdehyde; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Protective Agents; Random Allocation; Rats; Rats, Wistar; Trapidil; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Cell Count; Coumaric Acids; Drug Interactions; Free Radical Scavengers; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Interleukin-1; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peptide Fragments; Time Factors; Tyrosine | 2005 |
Detection and comparison of nitric oxide in clinically healthy horses and those with naturally acquired strangulating large colon volvulus.
Topics: Animals; Case-Control Studies; Colon; Colonic Diseases; Female; Horse Diseases; Horses; Immunohistochemistry; Intestinal Volvulus; Male; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tyrosine | 2005 |
Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury.
Topics: Aldehydes; Animals; Blotting, Northern; Blotting, Western; Cardiovascular Diseases; Copper; Diabetes Mellitus, Experimental; Endothelin-1; Glutathione; Immunohistochemistry; Interleukin-6; Iron; Metallothionein; Mice; Mice, Transgenic; Myocardium; Oxidative Stress; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Zinc | 2005 |
Advanced glycation end products induce death of retinal neurons via activation of nitric oxide synthase.
Topics: Amacrine Cells; Animals; Caspase 3; Caspases; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycation End Products, Advanced; In Situ Nick-End Labeling; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Retina; Tyrosine | 2005 |
The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage.
Topics: Animals; Cartilage, Articular; Dinoprostone; Female; Inflammation Mediators; Nitric Oxide; Oxygen; Stress, Mechanical; Swine; Tissue Culture Techniques; Tyrosine | 2005 |
Early administration of a second-generation perfluorochemical decreases ischemic brain damage in a model of permanent middle cerebral artery occlusion in the rat.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Drug Therapy, Combination; Fluorocarbons; Immunohistochemistry; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Necrosis; Neuroprotective Agents; Oxygen; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Silver Staining; Time Factors; Tyrosine | 2005 |
Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.
Topics: Actinin; Blotting, Western; Calcium; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Heart Ventricles; Humans; Immunoblotting; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Tyrosine | 2005 |
Selective quantification of free 3-nitrotyrosine in exhaled breath condensate in asthma using gas chromatography/tandem mass spectrometry.
Topics: Adult; Aged; Asthma; Biomarkers; Case-Control Studies; Exhalation; Female; Gas Chromatography-Mass Spectrometry; Humans; Inflammation; Male; Middle Aged; Oxidative Stress; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2005 |
The endothelin/nitric oxide balance determines small-for-size liver injury after reduced-size rat liver transplantation.
Topics: Animals; Apoptosis; Endothelin A Receptor Antagonists; Endothelins; Immunohistochemistry; Kupffer Cells; Liver; Liver Function Tests; Liver Regeneration; Liver Transplantation; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Phenylpropionates; Pyrimidines; Rats; Rats, Inbred Lew; Tyrosine | 2005 |
Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity.
Topics: Actins; Aldehydes; Animals; Blotting, Southern; Blotting, Western; Doxorubicin; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mitochondria, Heart; Myocytes, Cardiac; Nitrates; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2005 |
Reactive nitrogen species formation in eosinophils and imbalance in nitric oxide metabolism are involved in atopic dermatitis-like skin lesions in NC/Nga mice.
Topics: Allergens; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Dermatitis, Atopic; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Immunoglobulin E; Immunohistochemistry; Isoenzymes; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Reactive Oxygen Species; Tyrosine | 2005 |
Effect of nitration on protein tyrosine phosphatase and protein phosphatase activity in neuronal cell membranes of newborn piglets.
Topics: Animals; Animals, Newborn; Cell Membrane; Cerebral Cortex; Enzyme Inhibitors; Hypoxia, Brain; In Vitro Techniques; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peroxynitrous Acid; Protein Tyrosine Phosphatases; Tyrosine | 2005 |
Biochemical properties of cytochrome c nitrated by peroxynitrite.
Topics: Animals; Cyanides; Cytochromes c; Enzyme Stability; Fluoresceins; Oxidation-Reduction; Peroxidases; Peroxynitrous Acid; Protein Denaturation; Protein Folding; Superoxides; Tyrosine | 2006 |
Relationships between human serum resistin, inflammatory markers and insulin resistance.
Topics: Biomarkers; Blood Glucose; Body Composition; Body Mass Index; C-Reactive Protein; Case-Control Studies; Homeostasis; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Regression Analysis; Resistin; Triglycerides; Tyrosine; Uric Acid | 2005 |
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation.
Topics: Amphetamine; Animals; Behavior, Animal; CD11b Antigen; Cell Count; Diagnostic Imaging; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipopolysaccharides; Motor Activity; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Rats; S100 Proteins; Stereotyped Behavior; Substantia Nigra; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Calcimycin; Carotid Arteries; Cholesterol; Copper; Dietary Supplements; Ionophores; Muscle, Smooth; Nitric Oxide; Oxidative Stress; Rabbits; Superoxide Dismutase; Tyrosine | 2005 |
Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Chemokines; Cyclooxygenase 2; Female; Glucocorticoid-Induced TNFR-Related Protein; Interferon-gamma; Macrophage Inflammatory Proteins; Male; Mice; Mice, SCID; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage.
Topics: Animals; DNA Damage; Fibroblasts; Lipopolysaccharides; Methylnitrosourea; Mice; Mice, Knockout; Microtubules; Mitochondria; Mutation; NIH 3T3 Cells; Nitric Oxide Synthase Type II; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Superoxide Dismutase; Time Factors; Tyrosine | 2005 |
Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells.
Topics: Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Endometrium; Epithelial Cells; Female; Fibrinolysin; Growth Substances; Humans; Interleukin-1; Mass Spectrometry; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Menstruation; Mesoderm; Nitric Oxide Synthase Type II; Omentum; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
Topics: Annexin A5; Apoptosis; Blotting, Western; Calcium; Cell Line, Tumor; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Flavonoids; Flow Cytometry; Free Radicals; Guanosine Triphosphate; Humans; Membrane Potentials; Mitochondria; Models, Biological; Neurons; Nitric Oxide; Oxidopamine; Oxygen; Parkinson Disease; Phenols; Polyphenols; Quinones; Reactive Oxygen Species; Tea; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine | 2005 |
Differential expression of nitric oxide synthases in human scalp epidermal and hair follicle pigmentary units: implications for regulation of melanogenesis.
Topics: Adult; Aged; Female; Fluorescent Antibody Technique; Hair; Hair Follicle; Humans; Immunohistochemistry; Keratinocytes; Male; Melanins; Melanocytes; Middle Aged; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Scalp; Tyrosine | 2005 |
Green tea polyphenol extract attenuates colon injury induced by experimental colitis.
Topics: Animals; Benzenesulfonates; Chromatography, High Pressure Liquid; Colitis; Colon; Flavonoids; Heme Oxygenase (Decyclizing); Immunohistochemistry; Intercellular Adhesion Molecule-1; Male; Peroxidase; Phenols; Phytotherapy; Plant Leaves; Polyphenols; Rats; Rats, Sprague-Dawley; Tea; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model.
Topics: Acetylcholine; Animals; Blotting, Western; Collagen; Endothelin-1; Endothelium, Vascular; Fibrosis; Homocysteine; Hypertension, Renovascular; Hypoglycemic Agents; Kidney; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Nitroprusside; PPAR gamma; Proteinuria; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Tyrosine; Vasodilator Agents; Ventricular Remodeling | 2005 |
The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated nitrotyrosine formation and the catalytic activity of cytochrome P450 2B1.
Topics: Catalysis; Conserved Sequence; Cytochrome P-450 CYP2B1; Escherichia coli; Glutamine; Heme; Hydrogen Bonding; Iron; Kinetics; Models, Molecular; Molecular Sequence Data; Oxidoreductases; Peroxynitrous Acid; Plasmids; Temperature; Tyrosine | 2005 |
Melatonin limits lung injury in bleomycin treated mice.
Topics: Animals; Bleomycin; Immunohistochemistry; Lung; Male; Melatonin; Mice; Poly Adenosine Diphosphate Ribose; Pulmonary Fibrosis; Tyrosine | 2005 |
Protective action of a hexane crude extract of Pterodon emarginatus fruits against oxidative and nitrosative stress induced by acute exercise in rats.
Topics: Animals; Antioxidants; Brain; Creatine Kinase; Fabaceae; Fruit; Lactates; Lipid Peroxidation; Liver; Macrophages; Male; Muscle, Skeletal; Nitrites; Oxidative Stress; Physical Conditioning, Animal; Plant Extracts; Rats; Rats, Wistar; Tyrosine | 2005 |
Plasma nitrotyrosine levels, antioxidant vitamins and hyperglycaemia.
Topics: Age Factors; Antioxidants; Ascorbic Acid; Blood Glucose; Body Mass Index; Cohort Studies; Diabetes Mellitus; Diet; Humans; Hyperglycemia; Male; Middle Aged; Smoking; Tyrosine; Vitamin A; Vitamin E; Vitamins | 2005 |
Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion.
Topics: Catalysis; Computer Simulation; Diffusion; Dose-Response Relationship, Drug; Glutathione; Kinetics; Models, Biological; Nitric Oxide; Nitrogen; Oxygen; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2005 |
The effect of N-acetylcysteine on cardiac contractility to dobutamine in rats with streptozotocin-induced diabetes.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Dinoprost; Dobutamine; Dose-Response Relationship, Drug; Heart Rate; Immunohistochemistry; Male; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2005 |
Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III).
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Southern; Brain Injuries; Caspase 3; Caspases; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Agar Gel; gamma-Aminobutyric Acid; Huntington Disease; Lipid Peroxidation; Male; Mitochondria; Motor Activity; Nitric Oxide Synthase; Peroxynitrous Acid; Porphyrins; Quinolinic Acids; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Rotarod Performance Test; Superoxide Dismutase; Synaptic Vesicles; Synaptosomes; Tyrosine | 2005 |
Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite.
Topics: Blood Proteins; Deferoxamine; Humans; Lipid Peroxidation; Lipids; Oxidation-Reduction; Peroxynitrous Acid; Resveratrol; Stilbenes; Tyrosine | 2006 |
Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Female; Functional Laterality; Gene Expression Regulation; Hypoxia-Ischemia, Brain; Imino Pyranoses; Immunohistochemistry; Male; Nitric Oxide Synthase; Piperidines; Rats; Statistics, Nonparametric; Time Factors; Tyrosine | 2005 |
Hypoxia-induced skeletal muscle fiber dysfunction: role for reactive nitrogen species.
Topics: Animals; Enzyme Inhibitors; Hyperoxia; Hypoxia; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; omega-N-Methylarginine; Oxygen; Partial Pressure; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2006 |
Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension.
Topics: Administration, Oral; Animals; Chronic Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exhalation; Hypertension, Pulmonary; Hypoxia; Lung; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Pulmonary Artery; Rats; Rats, Wistar; Time Factors; Tyrosine | 2006 |
Nitric oxide inhalation inhibits inducible nitric oxide synthase but not nitrotyrosine formation and cell apoptosis in rat lungs with meconium-induced injury.
Topics: Administration, Inhalation; Animals; Apoptosis; Interleukin-1; Lung; Male; Malondialdehyde; Meconium; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Random Allocation; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; RNA, Messenger; Tyrosine | 2005 |
Roles of nitric oxide and nitric oxide synthases in tissue damage of obstructed ureters in rats.
Topics: Animals; Female; Muscle, Smooth; Nitric Oxide; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Ureteral Obstruction | 2005 |
Poly (ADP) ribose polymerase inhibition improves rat cardiac allograft survival.
Topics: Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Graft Survival; Heart Transplantation; Indoles; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Lew; Tyrosine | 2005 |
Tau is hyperphosphorylated in the insulin-like growth factor-I null brain.
Topics: Aging; Animals; Brain; Drug Residues; Insulin-Like Growth Factor I; Lipofuscin; Male; Mice; Mice, Knockout; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; tau Proteins; Tyrosine | 2005 |
Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors in a model of inflammation-based tumor progression.
Topics: Animals; Cell Movement; Cell Proliferation; Disease Progression; Female; Fibrosarcoma; Gelatin Sponge, Absorbable; Guanidine; Guanine; Inflammation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Nitric Oxide Synthase Type II; Oxidation-Reduction; Reactive Nitrogen Species; Tyrosine | 2006 |
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases | 2005 |
Effect of partial outlet obstruction on nitrotyrosine content and distribution within the rabbit bladder.
Topics: Animals; Nitric Oxide; Rabbits; Tissue Distribution; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2005 |
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.
Topics: Adrenergic Agents; Aldehydes; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; CD11b Antigen; Cell Count; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Functional Laterality; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Neurodegenerative Diseases; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Parkinsonian Disorders; Rats; Rats, Wistar; Reactive Oxygen Species; Rotarod Performance Test; Rotation; Substantia Nigra; Synaptophysin; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Effects of Hypericum perforatum extract in a rat model of ischemia and reperfusion injury.
Topics: Animals; Antioxidants; Blood Pressure; Cytokines; Densitometry; Flavonoids; Hydroxybenzoates; Hypericum; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Superior; Neutrophils; P-Selectin; Peroxidase; Phenols; Phytotherapy; Plant Extracts; Poly(ADP-ribose) Polymerases; Polyphenols; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Shock; Time Factors; Treatment Outcome; Tyrosine | 2005 |
Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma.
Topics: Animals; Antigens, CD; Blast Injuries; Cadherins; Cell Movement; Endothelial Cells; Epithelial Cells; Heme Oxygenase-1; Hemoglobins; Hemorrhage; Inflammation; Iron; Leukocytes; Male; Oxidative Stress; Peroxidase; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Superoxide Dismutase; Superoxide Dismutase-1; Transferrin; Tyrosine | 2006 |
Mediation of in vivo glucose sensor inflammatory response via nitric oxide release.
Topics: Animals; Biosensing Techniques; Blood Glucose; Calibration; Electrochemistry; Inflammation; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tyrosine | 2005 |
Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice.
Topics: Animals; Benzene; Bone Marrow; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Environmental Pollutants; Gas Chromatography-Mass Spectrometry; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Nitric Oxide; Protein Binding; Proteins; Tyrosine | 2005 |
Inhibition of nitric oxide synthase reduces renal ischemia/reperfusion injury.
Topics: Amidines; Animals; Benzylamines; Creatinine; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Kidney Tubules; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 2005 |
Sensitive and accurate analyses of free 3-nitrotyrosine in exhaled breath condensate by LC-MS/MS.
Topics: Adult; Biomarkers; Breath Tests; Chromatography, Liquid; Exhalation; Humans; Sensitivity and Specificity; Smoking; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Zingerone as an antioxidant against peroxynitrite.
Topics: Antioxidants; Free Radical Scavengers; Guaiacol; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine | 2005 |
Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition.
Topics: Animals; Blotting, Western; Cholesterol, Dietary; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxamic Acids; Hyperlipidemias; Indoles; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Matrix Metalloproteinase Inhibitors; Myocardial Infarction; Myocardium; Protease Inhibitors; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Tyrosine | 2006 |
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyrine; Brain; Brain Ischemia; Deoxyguanosine; DNA Damage; Edaravone; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Immunoblotting; Immunohistochemistry; Inflammation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reperfusion Injury; Time Factors; Tyrosine | 2005 |
Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Chronic Disease; Cysteine; Disease Models, Animal; Female; Fetus; Free Radical Scavengers; Lung; Lung Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Papio; Pregnancy; S-Nitrosothiols; Tyrosine | 2005 |
Effects of Tempol, a membrane-permeable radical scavenger, in a rodent model periodontitis.
Topics: Alveolar Bone Loss; Animals; Cyclic N-Oxides; Drug Evaluation, Preclinical; Free Radical Scavengers; Male; Mandibular Diseases; Models, Animal; Periodontitis; Poly(ADP-ribose) Polymerases; Random Allocation; Rats; Rats, Sprague-Dawley; Spin Labels; Tyrosine | 2005 |
L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction.
Topics: Animals; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Prostatic Hyperplasia; Rabbits; Reperfusion Injury; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2006 |
Effect of vitamin A pretreatment on Escherichia coli-induced lipid peroxidation and level of 3-nitrotyrosine in kidney of guinea pig.
Topics: Animals; Chromatography, High Pressure Liquid; Escherichia coli Infections; Guinea Pigs; Kidney; Lipid Peroxidation; Malondialdehyde; Tyrosine; Vitamin A | 2005 |
3-Nitrotyrosine modification of SERCA2a in the aging heart: a distinct signature of the cellular redox environment.
Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Calcium-Transporting ATPases; Cell Respiration; Heart; Male; Muscle, Skeletal; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Stress, Physiological; Tyrosine | 2005 |
[The effect of nitrogen monoxide and its synthase on the diabetic retinal damage].
Topics: Animals; Diabetic Retinopathy; Immunohistochemistry; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2005 |
Respiratory loading intensity and diaphragm oxidative stress: N-acetyl-cysteine effects.
Topics: Acetylcysteine; Animals; Antioxidants; Diaphragm; Dogs; Male; Muscle Fatigue; Oxidative Stress; Protein Carbonylation; Proteins; Respiration; Tyrosine; Work of Breathing | 2006 |
Effects of angiotensin-converting-enzyme inhibitors in combination with diuretics on blood pressure and renal injury in nitric oxide-deficiency-induced hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Diuretics; Drug Therapy, Combination; Enalapril; Hydrochlorothiazide; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin.
Topics: Aerobiosis; Animals; Blotting, Western; Cyclic N-Oxides; Free Radicals; Immune Sera; Immunochemistry; Myoglobin; Nitric Oxide; Nitrogen Dioxide; Nitrogen Oxides; Oxygen; Partial Pressure; Peroxynitrous Acid; Sperm Whale; Spin Trapping; Tyrosine | 2005 |
Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice.
Topics: Acetophenones; Acetylcholine; Animals; Aorta; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Endothelium, Vascular; Homeostasis; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; NADPH Oxidases; Nitric Oxide; Onium Compounds; Oxidation-Reduction; Oxidative Stress; Prediabetic State; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Receptors, Thromboxane A2, Prostaglandin H2; Tyrosine; Vasodilation | 2005 |
Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Graft Rejection; Heart Transplantation; Lysine; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Inbred Lew; Rats, Inbred WF; Superoxide Dismutase; Tyrosine | 2005 |
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Apoptosis; Atherosclerosis; Calcium; Cells, Cultured; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Female; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine; Umbilical Veins | 2005 |
Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, reduces acute lung injury in endotoxemic rats.
Topics: Anilides; Animals; Endotoxemia; Lipopolysaccharides; Lung; Male; Nitric Oxide; Nitric Oxide Synthase Type II; PPAR gamma; Rats; Rats, Wistar; Respiratory Distress Syndrome; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Tyrosine | 2005 |
Peroxisome proliferator-activated receptor-gamma ligands protect against lung injury: potential therapeutic targets?
Topics: Animals; Humans; Lung; Nitric Oxide; Nitric Oxide Synthase Type II; PPAR gamma; Rats; Respiratory Distress Syndrome; Rosiglitazone; Thiazolidinediones; Tyrosine | 2005 |
Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.
Topics: Adaptation, Physiological; Animals; Apoptosis; Blood Pressure; Caspase 3; Creatine Kinase; Dietary Supplements; Enzyme Activation; Glutathione; Heart Rate; Heart Ventricles; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Nitrates; Nitroglycerin; Rats; Recovery of Function; Tyrosine; Vasodilation | 2005 |
Easy oxidation and nitration of human myoglobin by nitrite and hydrogen peroxide.
Topics: Heme; Humans; Hydrogen Peroxide; Myoglobin; Nitrites; Oxidation-Reduction; Sulfinic Acids; Tyrosine | 2006 |
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Benzothiazoles; Body Weight; Caspase 3; Caspases; Cell Death; Cerebral Cortex; Cytarabine; Diagnostic Imaging; Dopamine and cAMP-Regulated Phosphoprotein 32; Doxorubicin; Dystonia; Electron Transport Complex III; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Locomotion; Male; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Posture; Psychomotor Performance; Rats; Rats, Inbred Lew; Rotenone; tau Proteins; Tauopathies; Thiazoles; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin; Uncoupling Agents | 2005 |
Kidney immune cell infiltration and oxidative stress contribute to prenatally programmed hypertension.
Topics: Animals; Antioxidants; Cell Movement; Cyclic N-Oxides; Female; Hypertension, Renal; Immunosuppressive Agents; Kidney; Leukocytes; Male; Mycophenolic Acid; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Pregnancy; Rats; Spin Labels; Tyrosine | 2005 |
Increased oxidative-related mechanisms in the spinal cord injury in old rats.
Topics: Age Factors; Analysis of Variance; Animals; Disease Models, Animal; Immunohistochemistry; Laminectomy; Male; Oxidation-Reduction; Peroxidase; Poly Adenosine Diphosphate Ribose; Rats; Spinal Cord Injuries; Time Factors; Tyrosine | 2006 |
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain Chemistry; Caspase 3; Caspases; Cholinergic Fibers; Disease Models, Animal; Immunohistochemistry; Memory Disorders; Mice; Mice, Transgenic; Pedunculopontine Tegmental Nucleus; REM Sleep Behavior Disorder; Tyrosine | 2005 |
Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death.
Topics: Animals; Cardiopulmonary Resuscitation; Disease Models, Animal; Dogs; Female; Heart Arrest; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Neurons; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Pyruvate Dehydrogenase Complex; Tyrosine | 2006 |
Extracellular superoxide dismutase and oxidant damage in osteoarthritis.
Topics: Adult; Aged; Animals; Cartilage, Articular; Disease Models, Animal; Female; Femur Head; Free Radical Scavengers; Hindlimb; Humans; Male; Mice; Mice, Inbred CBA; Nitric Oxide Synthase; Osteoarthritis, Hip; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tibia; Tyrosine | 2005 |
[Experimental study on the effects of nitric oxide inhalation on formation of lung nitrotyrosine and apoptosis of alveolar cells].
Topics: Alveolar Epithelial Cells; Animals; Apoptosis; Lung; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tyrosine | 2005 |
Tubulin nitration in human gliomas.
Topics: Aged; Astrocytes; Blotting, Western; Brain Neoplasms; Chromatography, High Pressure Liquid; Female; Glioma; Humans; Immunohistochemistry; Male; Middle Aged; Neurons; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tubulin; Tyrosine | 2006 |
Determination of 3-nitrotyrosine in human urine at the basal state by gas chromatography-tandem mass spectrometry and evaluation of the excretion after oral intake.
Topics: Administration, Oral; Adult; Biomarkers; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Reactive Nitrogen Species; Reproducibility of Results; Tyrosine | 2005 |
Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Embryo, Mammalian; Endothelin-1; Female; Immunohistochemistry; Nitrates; Nitric Oxide; Nitrites; Organogenesis; Pregnancy; Pregnancy in Diabetics; Prostaglandin D2; Rats; Rats, Wistar; Tyrosine | 2005 |
Sevelamer prevents uremia-enhanced atherosclerosis progression in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Collagen; Disease Progression; Macrophages; Mice; Mice, Knockout; Monocytes; Placebos; Polyamines; Sevelamer; Tyrosine; Uremia | 2005 |
Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis.
Topics: Adult; Blood Platelets; Case-Control Studies; Cell-Free System; Class II Phosphatidylinositol 3-Kinases; Female; Humans; Kinetics; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Protein Processing, Post-Translational; Scleroderma, Systemic; Tyrosine | 2006 |
Antioxidative role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Gene Expression; Glycoproteins; Heme Oxygenase-1; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Respiratory Distress Syndrome; Tyrosine | 2005 |
Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities.
Topics: Animals; Catalase; Glutathione Peroxidase; Hypothyroidism; Immunohistochemistry; Kidney; Male; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2005 |
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease.
Topics: Aged; Bronchi; Bronchitis; Case-Control Studies; Cell Count; Epithelium; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Pulmonary Disease, Chronic Obstructive; Reactive Nitrogen Species; Respiratory Mucosa; Smoking; Tyrosine; Vital Capacity; Xanthine Oxidase | 2005 |
Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition.
Topics: Animals; Electron Transport Complex I; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Proteomics; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfhydryl Compounds; Tyrosine | 2006 |
Hypertension induced by aortic coarctation above the renal arteries is associated with immune cell infiltration of the kidneys.
Topics: Angiotensin II; Animals; Aortic Coarctation; Chemokine CCL2; Flow Cytometry; Hydrogen Peroxide; Hypertension, Renovascular; Integrins; Kidney; Leukocytes; Lymphocytes; Macrophages; Male; Rats; Rats, Sprague-Dawley; Tyrosine | 2005 |
Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Arsenates; Arsenites; Cell Line; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Humans; Keratinocytes; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Sodium Compounds; Superoxide Dismutase; Time Factors; Tyrosine | 2005 |
Peroxynitrite mediates TNF-alpha-induced endothelial barrier dysfunction and nitration of actin.
Topics: Actins; Albumins; Animals; Capillary Permeability; Cattle; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Lung; Microcirculation; Nitrates; Peroxynitrous Acid; Protein Isoforms; Rats; Tissue Distribution; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 2006 |
Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice.
Topics: Amidines; Animals; Benzylamines; Enzyme Inhibitors; Immunohistochemistry; Male; Mice; Mice, Knockout; Microcirculation; Muscle, Skeletal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2005 |
Nitrotyrosine in otitis media with effusion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Colorimetry; Female; Humans; L-Lactate Dehydrogenase; Middle Aged; Nitric Oxide; Otitis Media with Effusion; Superoxide Dismutase; Tyrosine | 2005 |
Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension.
Topics: Aldehydes; Animals; Blood Pressure; Cardiotonic Agents; Desoxycorticosterone; Heart; Hypertension; Hypertrophy, Left Ventricular; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Sodium Chloride; Tyrosine | 2005 |
Gentamicin induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pig.
Topics: Afferent Pathways; Animals; Anti-Bacterial Agents; Apoptosis; Auditory Pathways; Female; Gentamicins; Guinea Pigs; Hair Cells, Auditory; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Saccule and Utricle; Tyrosine; Vestibule, Labyrinth | 2006 |
8-Nitroguanine formation in oral leukoplakia, a premalignant lesion.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Biomarkers, Tumor; Deoxyguanosine; Female; Fluorescent Antibody Technique; Guanine; Humans; Leukoplakia, Oral; Male; Middle Aged; Mouth Mucosa; Nitric Oxide Synthase Type II; Oxidative Stress; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Tumor Suppressor Protein p53; Tyrosine | 2006 |
Quantification of 3-nitrotyrosine levels using a benchtop ion trap mass spectrometry method.
Topics: Animals; Asthma; Chromatography, High Pressure Liquid; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Proteins; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Enzyme Inhibitors; Lipase; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Neutrophils; Nitric Oxide; Pancreas; Pancreatitis; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2005 |
Nitric oxide protects against mitochondrial permeabilization induced by glutathione depletion: role of S-nitrosylation?
Topics: Cell Death; Cell Line, Tumor; Glutathione; Humans; Mercuric Chloride; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Nitric Oxide; Oxidation-Reduction; Permeability; Sulfhydryl Compounds; Tyrosine | 2006 |
Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain.
Topics: Aldehydes; Animals; Anions; Antibiotics, Antineoplastic; Blotting, Western; Brain; Doxorubicin; Free Radicals; Glutathione Transferase; Humans; Ions; Lipid Peroxidation; Male; Mice; Multidrug Resistance-Associated Proteins; Oxidation-Reduction; Oxidative Stress; Oxygen; Proteins; Reactive Oxygen Species; Time Factors; Tyrosine | 2005 |
Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice.
Topics: Acute Disease; Animals; Biomarkers; Chagas Cardiomyopathy; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nitric Oxide; Parasitemia; Tyrosine | 2005 |
Immunomodulatory effects of etanercept in an experimental model of spinal cord injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cyclooxygenase 2; Etanidazole; Immunologic Factors; Interleukin-1; Male; Mice; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Opposite effects of pre- and postischemic treatments with nitric oxide donor on ischemia/reperfusion-induced renal injury.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Ischemia; Kidney; Male; Neutrophil Infiltration; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitro Compounds; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxides; Time Factors; Tyrosine | 2006 |
Low plasma protein nitrotyrosine levels distinguish primary Raynaud's phenomenon from scleroderma.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Blood Proteins; Chromatography, Gas; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Raynaud Disease; Scleroderma, Systemic; Tyrosine | 2006 |
Increase in heme oxygenase-1 levels ameliorates renovascular hypertension.
Topics: Aldosterone; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension, Renal; Juxtaglomerular Apparatus; Kidney; Male; Metalloporphyrins; Organ Size; Protoporphyrins; Rats; Rats, Sprague-Dawley; Renin; Tyrosine | 2005 |
Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin.
Topics: Animals; Body Weight; Calmodulin; Caveolin 1; Down-Regulation; Guanylate Cyclase; Immunohistochemistry; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Obesity; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tyrosine | 2005 |
Adreno-leukodystrophy: oxidative stress of mice and men.
Topics: Adrenal Cortex; Adrenoleukodystrophy; Animals; Biochemistry; Biomarkers; Brain; Chemokine CCL22; Chemokines, CC; Humans; Immunohistochemistry; Interferon-gamma; Interleukin-12; Kidney Cortex; Liver; Mice; Mice, Knockout; Mitochondria; Oxidative Stress; Superoxide Dismutase; Tyrosine | 2005 |
Antioxidant enzymes in renal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Renal Cell; Catalase; Female; Glutamate-Cysteine Ligase; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Kidney Neoplasms; Male; Middle Aged; Superoxide Dismutase; Thioredoxin-Disulfide Reductase; Thioredoxins; Tyrosine | 2006 |
The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Arginine; Colonic Neoplasms; Dietary Supplements; Female; Intestinal Neoplasms; Intestine, Small; Male; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tyrosine | 2006 |
Reduced neuronal injury after treatment with NG-nitro-L-arginine methyl ester (L-NAME) or 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) following experimental brain contusion.
Topics: Animals; Apoptosis; Benzenesulfonates; Brain; Brain Injuries; Cell Survival; Drug Combinations; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Immunohistochemistry; In Situ Nick-End Labeling; Male; Nerve Degeneration; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organic Chemicals; Rats; Rats, Sprague-Dawley; Tyrosine | 2005 |
Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Brain; Copper; Deoxyguanosine; DNA Damage; Epithelium; Female; Fetal Development; Glutathione Peroxidase; Growth Inhibitors; Heart Defects, Congenital; Indicators and Reagents; Lipids; Mice; Neural Tube Defects; Peroxynitrous Acid; Pregnancy; Superoxide Dismutase; Superoxides; Tyrosine | 2006 |
Altered protein expression and protein nitration pattern during d-galactosamine-induced cell death in human hepatocytes: a proteomic analysis.
Topics: Apoptosis; Cell Death; Cells, Cultured; Galactosamine; Hepatocytes; Humans; Necrosis; Nitrates; Oxidative Stress; Proteins; Proteomics; Tyrosine | 2005 |
3-Nitrotyrosine, a marker of nitrosative stress, is increased in breath condensate of allergic asthmatic children.
Topics: Adolescent; Anti-Asthmatic Agents; Asthma; Biomarkers; Breath Tests; Case-Control Studies; Child; Female; Humans; Male; Nitric Oxide; Probability; Reference Values; Respiratory Function Tests; Sensitivity and Specificity; Severity of Illness Index; Spirometry; Tyrosine | 2006 |
Nitration and inactivation of IDO by peroxynitrite.
Topics: Amino Acid Sequence; Blotting, Western; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukocytes, Mononuclear; Molecular Sequence Data; Mutagenesis, Site-Directed; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2006 |
Systemic and pituitary pars intermedia antioxidant capacity associated with pars intermedia oxidative stress and dysfunction in horses.
Topics: Age Factors; alpha-MSH; Animals; Antioxidants; Erythrocytes; Glutathione; Glutathione Peroxidase; Horse Diseases; Horses; Oxidative Stress; Pituitary Diseases; Pituitary Gland; Superoxide Dismutase; Tyrosine | 2005 |
Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.
Topics: Aldehydes; Animals; Antioxidants; Blotting, Western; Buthionine Sulfoximine; Catalysis; Cell Line; Cell Survival; Cyclosporine; Cytochrome P-450 CYP2E1; DNA, Complementary; Endoplasmic Reticulum; Ethanol; Flow Cytometry; Glutathione; Humans; Liver; Liver Diseases, Alcoholic; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria; Mitochondria, Liver; Oxidative Stress; Plasmids; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Time Factors; Transfection; Tyrosine | 2006 |
Difference and similarity between non-alcoholic steatohepatitis and alcoholic liver disease.
Topics: Abdomen; Adipose Tissue; Adult; Data Collection; Diagnosis, Differential; Fatty Liver; Female; Hepatitis, Alcoholic; Humans; Immunohistochemistry; Iron; Lipid Peroxidation; Liver; Male; Middle Aged; Tomography, X-Ray Computed; Tyrosine | 2005 |
Low molecular weight thiol amides attenuate MAPK activity and protect primary neurons from Abeta(1-42) toxicity.
Topics: Acetylcysteine; Amides; Amyloid beta-Peptides; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Glutathione; Lipid Peroxidation; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Weight; Neurons; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Tyrosine | 2006 |
3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor.
Topics: Animals; Corpus Striatum; Dopamine; Male; Neurons; Neurotoxins; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Wistar; Substantia Nigra; Tyrosine | 2006 |
Nitrotyrosine formation and apoptosis in rat models of ocular injury.
Topics: Animals; Apoptosis; Blotting, Western; Eye Injuries; In Situ Nick-End Labeling; Lipopolysaccharides; Male; Models, Animal; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Retina; Tyrosine | 2006 |
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
Topics: Aging; Animals; Calcium-Transporting ATPases; Cardiovascular Diseases; Dithionite; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Kidney; Oxidative Stress; Peroxynitrous Acid; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Tyrosine | 2006 |
Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production.
Topics: Animals; Aorta; Apolipoproteins E; Blotting, Northern; Blotting, Western; Cells, Cultured; Coronary Artery Disease; Eicosanoids; Female; Fluorescent Antibody Technique; Immunohistochemistry; Male; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Tyrosine | 2006 |
Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells.
Topics: Animals; Bacterial Proteins; Biomarkers, Tumor; Biotin; Carcinoma, Hepatocellular; Central Nervous System Depressants; Computational Biology; Cytochrome P-450 CYP2E1; Cytosol; Electrophoresis, Gel, Two-Dimensional; Ethanol; Liver; Liver Extracts; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peroxidases; Peroxiredoxins; Sepharose; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.
Topics: Absorption; Animals; Apoptosis; Caco-2 Cells; Caspase 3; Caspases; Catechin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flavonoids; Gastrointestinal Tract; Humans; In Vitro Techniques; Mitogen-Activated Protein Kinase Kinases; Nitrosamines; Nitroso Compounds; Nitrous Acid; Phenols; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Reactive Nitrogen Species; Time Factors; Tyrosine | 2006 |
Nitric oxide in papillary thyroid carcinoma: induction of vascular endothelial growth factor D and correlation with lymph node metastasis.
Topics: Adolescent; Adult; Aged; Carcinoma, Papillary; Cell Line, Tumor; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; RNA, Messenger; Thyroid Neoplasms; Tyrosine; Vascular Endothelial Growth Factor D | 2006 |
Nitric oxide synthases are associated with bronchial dysplasia.
Topics: Aged; Analysis of Variance; Biomarkers; Bronchi; Bronchoscopy; Cell Transformation, Neoplastic; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Precancerous Conditions; Pulmonary Disease, Chronic Obstructive; Smoking; Tyrosine | 2006 |
Calcineurin regulates myocardial function during acute endotoxemia.
Topics: Animals; Calcineurin Inhibitors; Cats; Cyclosporine; Endotoxemia; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Contraction; Myocardium; Nitric Oxide Synthase Type II; Peroxidase; Protein Carbonylation; Superoxide Dismutase; Tacrolimus; Tyrosine | 2006 |
In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Bridged-Ring Compounds; Disease Models, Animal; Free Radicals; Gerbillinae; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Norbornanes; Oxidative Stress; Peptide Fragments; Reactive Oxygen Species; Synaptosomes; Thiocarbamates; Thiones; Type C Phospholipases; Tyrosine | 2006 |
Nitration of profilin effects its interaction with poly (L-proline) and actin.
Topics: Actins; Animals; Cattle; Nitrates; Peptides; Peroxynitrous Acid; Profilins; Spleen; Tyrosine | 2005 |
In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Creatinine; Cysteine; Eating; Erythrocytes; Female; Glutathione; Glutathione Disulfide; Glycine; Humans; Hydrogen Peroxide; Isoprostanes; Male; Statistics, Nonparametric; Tyrosine | 2006 |
Rosiglitazone reduces the evolution of experimental periodontitis in the rat.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ligation; Male; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Periodontitis; Poly(ADP-ribose) Polymerase Inhibitors; PPAR gamma; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rosiglitazone; Thiazolidinediones; Tyrosine | 2006 |
Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Diet, Atherogenic; Down-Regulation; Glucosephosphate Dehydrogenase Deficiency; Male; Mice; Mice, Knockout; Mutation; Nitric Oxide Synthase Type II; Superoxides; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2006 |
Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation.
Topics: Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Humans; Hydrogen Bonding; Manganese; Models, Molecular; Peroxynitrous Acid; Protein Conformation; Superoxide Dismutase; Tyrosine | 2006 |
Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blotting, Western; Cardiovascular Diseases; Case-Control Studies; Cells, Cultured; Chromatography, High Pressure Liquid; Copper; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Lipoproteins, LDL; Male; Methionine; Middle Aged; Nitrites; Osteoarthritis; Receptors, Scavenger; Tyrosine; Umbilical Veins | 2006 |
The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts.
Topics: Animals; Biomarkers; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Myocardial Reperfusion Injury; Myocardium; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitro Compounds; Peroxynitrous Acid; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxide Dismutase; Tyrosine; Xanthine Oxidase | 2006 |
Markers of oxidative stress in placental villi exposed to ethanol.
Topics: Aldehydes; Biomarkers; Ethanol; Female; Guanosine; Humans; Oxidative Stress; Placenta; Pregnancy; Trophoblasts; Tyrosine | 2006 |
The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.
Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Captopril; Enalaprilat; Female; Glucose; Humans; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Middle Aged; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Proteins c-akt; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrosine | 2006 |
Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteries.
Topics: Actins; Animals; Blood Pressure; Brain; Cerebral Arteries; Humans; Infarction, Middle Cerebral Artery; Ischemia; Male; Microscopy, Confocal; Muscle, Smooth, Vascular; Peroxynitrous Acid; Posterior Cerebral Artery; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Time Factors; Tyrosine | 2006 |
Electrochemical detection of free 3-nitrotyrosine: application to microdialysis studies.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Microdialysis; Oxidation-Reduction; Rats; Reproducibility of Results; Tyrosine | 2006 |
Increased sensitivity to asbestos-induced lung injury in mice lacking extracellular superoxide dismutase.
Topics: Animals; Asbestos, Crocidolite; Bronchoalveolar Lavage Fluid; Hydroxyproline; Inflammation; Lung; Lung Diseases; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Superoxide Dismutase; Tyrosine | 2006 |
Biodegradation of 3-nitrotyrosine by Burkholderia sp. strain JS165 and Variovorax paradoxus JS171.
Topics: 3,4-Dihydroxyphenylacetic Acid; Biodegradation, Environmental; Burkholderia; Comamonadaceae; Models, Biological; Molecular Sequence Data; Nitrophenols; Phenylacetates; RNA, Bacterial; RNA, Ribosomal, 16S; Soil Microbiology; Tyrosine | 2006 |
Expression and activity patterns of nitric oxide synthases and antioxidant enzymes reveal a substantial heterogeneity between cardiac and vascular aging in the rat.
Topics: Aging; Animals; Femoral Artery; Glutathione; Heart; In Vitro Techniques; Isoenzymes; Male; Myocardial Stunning; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perfusion; Rats; Rats, Inbred F344; Renal Artery; Superoxide Dismutase; Tyrosine | 2005 |
High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis.
Topics: Aconitate Hydratase; Animals; Apoptosis; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Ceramides; Dietary Fats; Forkhead Box Protein O3; Forkhead Transcription Factors; In Vitro Techniques; Male; Myocytes, Cardiac; Nitric Oxide Synthase; Obesity; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sirtuin 1; Sirtuins; STAT3 Transcription Factor; Triglycerides; Tyrosine; Up-Regulation | 2006 |
Peroxynitrite induces F-actin depolymerization and blockade of myosin ATPase stimulation.
Topics: Actins; Animals; Calorimetry, Differential Scanning; Enzyme Activation; Molsidomine; Myosins; Oxidation-Reduction; Peroxynitrous Acid; Protein Denaturation; Protein Folding; Rabbits; Temperature; Tyrosine | 2006 |
Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus.
Topics: Amidines; Amyloid beta-Peptides; Animals; Astrocytes; Benzylamines; Blood-Brain Barrier; CD11b Antigen; Cell Count; Drug Interactions; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Male; Microglia; Minocycline; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Tyrphostin AG 126 reduces intestinal ischemia-reperfusion injury in the rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-1beta; Intestines; Lipid Peroxidation; Male; Mesenteric Artery, Superior; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2006 |
Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.
Topics: Alkenes; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53; Tyrosine; Vascular Endothelial Growth Factor C | 2006 |
Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease.
Topics: Aerobiosis; Animals; Biomarkers; Calcium-Transporting ATPases; Cardiovascular Diseases; Humans; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Tyrosine | 2006 |
Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides.
Topics: Dengue Virus; Escherichia coli; Fluorescence; ortho-Aminobenzoates; Peptide Library; RNA Helicases; Serine; Serine Endopeptidases; Substrate Specificity; Tyrosine; Viral Nonstructural Proteins | 2006 |
Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?
Topics: Animals; Humans; Oxidative Stress; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury.
Topics: Animals; Cyclic GMP; Energy Metabolism; Male; Mice; Mice, Knockout; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Tyrosine; Up-Regulation | 2006 |
Prevalence of anti-3-nitrotyrosine antibodies in the joint synovial fluid of patients with rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus.
Topics: Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Osteoarthritis; Spectrum Analysis; Synovial Fluid; Tyrosine | 2006 |
Are oxidative mechanisms primary in ethanol induced Purkinje neuron death of the neonatal rat?
Topics: Acetylcysteine; Animals; Animals, Newborn; Cell Count; Cell Death; Cerebellum; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Free Radical Scavengers; Male; Peroxynitrous Acid; Pregnancy; Purkinje Cells; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke.
Topics: Animals; Brain Chemistry; Brain Ischemia; Glutathione; Glutathione Disulfide; Lipid Peroxidation; Lipids; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Stroke; Structure-Activity Relationship; Tyrosine | 2006 |
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite.
Topics: Actins; Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Catalysis; Cysteine; Dose-Response Relationship, Drug; Enzyme Stability; Magnesium; Molsidomine; Myosin Subfragments; Oxidation-Reduction; Peroxynitrous Acid; Protein Folding; Rabbits; Skeletal Muscle Myosins; Temperature; Time Factors; Tyrosine | 2006 |
Distribution and expression pattern of the nitrergic system in the cerebellum of the sheep.
Topics: Animals; Cerebellum; Immunohistochemistry; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Sheep; Tyrosine | 2006 |
Differences in oxidative stress dependence between gastric adenocarcinoma subtypes.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers; Carcinoma in Situ; Deoxyguanine Nucleotides; DNA, Neoplasm; Female; Gastric Mucosa; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Precancerous Conditions; Retrospective Studies; Stomach Neoplasms; Tyrosine | 2006 |
Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy.
Topics: Animals; Blotting, Northern; Brain Hemorrhage, Traumatic; Calpain; Cytoskeleton; Male; Membrane Lipids; Membrane Proteins; Mice; Microscopy, Electron; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2006 |
Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection.
Topics: Animals; Arginine; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Interleukin-1; Interleukin-6; Lung; Lung Diseases; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pseudomonas Infections; Rats; Rats, Inbred WKY; Tyrosine; Vascular Endothelial Growth Factor A | 2006 |
Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasoconstriction.
Topics: Animals; Burns; Female; Hypoxia; Lung; Multiple Trauma; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Pulmonary Gas Exchange; Random Allocation; Respiratory Distress Syndrome; Sheep; Single-Blind Method; Smoke Inhalation Injury; Survival Analysis; Tyrosine; Vasoconstriction | 2006 |
Protein co-expression with axonal injury in multiple sclerosis plaques.
Topics: Amyloid beta-Peptides; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Axons; Biomarkers; Brain; Calpain; CD3 Complex; Humans; Immunohistochemistry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Multiple Sclerosis; Nitric Oxide Synthase Type II; Osteopontin; Plaque, Amyloid; Proteins; Sialoglycoproteins; T-Lymphocytes; Tyrosine | 2006 |
Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice.
Topics: Adenoviridae; Alanine Transaminase; Animals; Aspartate Aminotransferases; beta-Galactosidase; Caspases; Cytochrome P-450 CYP2E1; Genetic Vectors; In Situ Nick-End Labeling; Liver; Male; Mice; Mice, Inbred C57BL; Protein Binding; Tyrosine | 2006 |
Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells.
Topics: Algal Proteins; Aniline Compounds; Antibodies, Anti-Idiotypic; Cells, Cultured; Cyclic GMP; Fluoresceins; Fungal Proteins; Molsidomine; Nicotiana; Nitric Oxide; Peroxynitrous Acid; Phytophthora; Proteins; Reactive Oxygen Species; Superoxides; Tyrosine; Uric Acid | 2006 |
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Ligusticum; Male; Neuroprotective Agents; Neutrophils; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Wistar; Respiratory Burst; Telencephalon; Tyrosine | 2006 |
Nitration of cardiac proteins is associated with abnormal cardiac chronotropic responses in rats with biliary cirrhosis.
Topics: Acetylcysteine; Animals; Enzyme Inhibitors; Heart Rate; Immunohistochemistry; Liver Cirrhosis, Biliary; Male; Microscopy, Electron; Muscle Proteins; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Osmolar Concentration; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Tyrosine | 2006 |
Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy.
Topics: Animals; Apoptosis; Cattle; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Guanosine; Mitochondria; Nitrosation; Oxidative Stress; Rats; Rats, Wistar; Retina; Retinal Vessels; RNA, Messenger; Superoxide Dismutase; Transfection; Tyrosine | 2006 |
Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats.
Topics: Animals; Capillary Permeability; Chromonar; Male; Neutrophil Infiltration; Periodontitis; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Blotting, Western; C-Reactive Protein; Heart; Immunohistochemistry; In Situ Nick-End Labeling; Isoproterenol; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; RNA; Stress, Physiological; Tyrosine | 2006 |
The production of peroxynitrite by human spermatozoa may affect sperm motility through the formation of protein nitrotyrosine.
Topics: Adult; Humans; Infertility, Male; Male; Peroxynitrous Acid; Sperm Motility; Spermatozoa; Tyrosine | 2006 |
Antibodies against nitric oxide damaged poly L-tyrosine and 3-nitrotyrosine levels in systemic lupus erythematosus.
Topics: Antibody Specificity; Antigen-Antibody Reactions; Autoantibodies; DNA; Electrophoresis, Agar Gel; Enzyme-Linked Immunosorbent Assay; Humans; Lupus Erythematosus, Systemic; Nitric Oxide; Peptides; Spectrophotometry, Ultraviolet; Tyrosine | 2006 |
Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress.
Topics: Aconitate Hydratase; Aging; Animals; Apoptosis; Calcium; Cytochromes c; Diastole; Gene Expression Regulation; Heart Ventricles; Metallothionein; Mice; Mice, Transgenic; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Pyrogallol; rhoA GTP-Binding Protein; Superoxides; Tyrosine | 2006 |
Age-associated tyrosine nitration of rat skeletal muscle glycogen phosphorylase b: characterization by HPLC-nanoelectrospray-tandem mass spectrometry.
Topics: Aging; Animals; Base Sequence; Chromatography, High Pressure Liquid; Glycogen Phosphorylase, Muscle Form; Longevity; Molecular Sequence Data; Muscle, Skeletal; Peroxynitrous Acid; Rats; Rats, Inbred BN; Rats, Inbred F344; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2006 |
Determination of nitrotyrosine and tyrosine by high-performance liquid chromatography with tandem mass spectrometry and immunohistochemical analysis in livers of mice administered acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chromatography, High Pressure Liquid; Liver; Male; Mass Spectrometry; Mice; Tyrosine | 2006 |
Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.
Topics: Adult; Animals; Asthma; Catalase; Cell Line; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovalbumin; Oxidation-Reduction; Proteome; Proteomics; Reactive Nitrogen Species; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
Impact of angiotensin-converting enzyme inhibition on renal cortical nitrotyrosine content during increased extracellular glucose concentration.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Glucose; Kidney Cortex; Male; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tyrosine | 2006 |
Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Collagen Type II; Cyclooxygenase 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hindlimb; Interleukin-6; Leukocyte Count; Macrophage Inflammatory Proteins; Mice; Mice, Inbred DBA; Monokines; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Radiography; Thiadiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells.
Topics: Aldehyde Reductase; Animals; Body Weight; Diabetes Mellitus, Experimental; Enzyme Activation; Glucose; Immunohistochemistry; Kidney; Male; Mesangial Cells; Nitrogen; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine | 2006 |
Glutathione reverses peroxynitrite-mediated deleterious effects of nitroglycerin on ischemic rat hearts.
Topics: Animals; Apoptosis; Glutathione; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitroglycerin; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hepatocytes; Imines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2006 |
Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector.
Topics: Animals; Animals, Newborn; Brain; Brain Diseases; Cell Death; Female; Gene Expression; Gene Transfer Techniques; Genetic Vectors; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Long-Evans; Superoxide Dismutase; Transgenes; Tyrosine | 2006 |
Acute renal failure: determinants and characteristics of the injury-induced hyperinflammatory response.
Topics: Acute Kidney Injury; Animals; Chemokine CCL2; Cisplatin; Endotoxins; Glycerol; Heme Oxygenase-1; Inflammation; Kidney; Lipopolysaccharides; Male; Metalloporphyrins; Mice; Nitric Oxide Synthase Type II; Protoporphyrins; Teichoic Acids; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2006 |
3-Nitrotyrosine as a spectroscopic probe for investigating protein protein interactions.
Topics: Amino Acid Substitution; Binding Sites; Energy Transfer; Fluorescence; Hirudins; Models, Molecular; Protein Binding; Protein Conformation; Protein Interaction Mapping; Structure-Activity Relationship; Thrombin; Tyrosine | 2006 |
Generation of nitric oxide in the opossum lower esophageal sphincter during physiological experimentation.
Topics: Animals; Antioxidants; Blotting, Western; Catalase; Esophageal Sphincter, Lower; Esophageal Sphincter, Upper; Female; Lipopolysaccharides; Luminescence; Male; Muscles; Nitric Oxide; Nitric Oxide Synthase Type II; Opossums; Superoxide Dismutase; Time Factors; Tyrosine | 2006 |
Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into alpha-tubulin in a mouse neuroblastoma cell line.
Topics: Androgen Antagonists; Animals; Brain; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Shape; Flutamide; Free Radicals; Mice; Neuroblastoma; Neuronal Plasticity; Neurons; Neuroprotective Agents; Oxidative Stress; Receptors, Androgen; Testosterone; Tubulin; Tyrosine; Up-Regulation | 2006 |
Cabergoline scavenges peroxynitrite enhanced by L-DOPA therapy in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Cabergoline; Chromatography, High Pressure Liquid; Ergolines; Female; Free Radical Scavengers; Humans; Levodopa; Male; Oxidative Stress; Parkinson Disease; Peroxynitrous Acid; Tyrosine | 2006 |
Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD.
Topics: Aged; Aldehydes; Biomarkers; Breath Tests; Female; Humans; Immunohistochemistry; Lactoferrin; Male; Middle Aged; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Smoking; Sputum; Tyrosine | 2006 |
Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications.
Topics: Animals; Antioxidants; beta Carotene; Carotenoids; Cell Line; Cell Survival; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Lycopene; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Tyrosine | 2006 |
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Cortex; Disease Models, Animal; Homozygote; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitochondria; Oxidative Stress; Respiration; Superoxide Dismutase; Tyrosine | 2006 |
Production of nitric oxide and self-nitration of proteins during monocyte differentiation to dendritic cells.
Topics: Adult; Arginase; Cell Differentiation; Dendritic Cells; Female; Fluorescent Antibody Technique; Humans; Male; Monocytes; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Tyrosine | 2005 |
Effect of partial bladder outlet obstruction on nitrotyrosine levels and their correlation with contractile function.
Topics: Animals; Disease Models, Animal; Free Radicals; Male; Muscle Contraction; Muscle, Smooth; Organ Size; Rabbits; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2006 |
N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats.
Topics: Acetylcysteine; Animals; Blood Glucose; Blood Pressure; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; Free Radical Scavengers; Heart Rate; Immunohistochemistry; Insulin; Isoprostanes; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Stress, Physiological; Triglycerides; Tyrosine | 2006 |
Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Chlorogenic Acid; Endothelium, Vascular; Hydrogen Peroxide; Immunohistochemistry; In Vitro Techniques; Male; NADP; NADPH Oxidases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Quinic Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Tyrosine; Vasodilation | 2006 |
Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury.
Topics: Acute Disease; alpha-Tocopherol; Animals; Antioxidants; Burns; Disease Models, Animal; Extravascular Lung Water; gamma-Tocopherol; Lipids; Lung; Lung Injury; Pulmonary Gas Exchange; Pulmonary Wedge Pressure; Sheep; Smoke Inhalation Injury; Tyrosine | 2006 |
The vascular smooth muscle cells apoptosis in asymptomatic diabetic carotid plaques: role of glycemic control.
Topics: Actins; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Blood Glucose; Carotid Stenosis; Caspase 3; Caspases; Collagen; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Female; Glycated Hemoglobin; Humans; Hyperglycemia; In Situ Nick-End Labeling; Interleukin-1; Macrophages; Male; Muscle, Smooth, Vascular; Oxidative Stress; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Nitric oxide synthase in muscular dystrophies: a re-evaluation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Arginase; Blotting, Western; Cell Survival; Child, Preschool; Cyclic AMP Response Element-Binding Protein; Female; Fluorescent Antibody Technique; Guanylate Cyclase; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Isoenzymes; Male; Muscle, Skeletal; Muscular Dystrophies; Muscular Dystrophy, Duchenne; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Tyrosine | 2006 |
Neuroprotection and enhanced recovery with hypericum perforatum extract after experimental spinal cord injury in mice.
Topics: Animals; Hypericum; Inflammation; Male; Mice; Neutrophil Infiltration; Oxidative Stress; Phytotherapy; Plant Extracts; Poly Adenosine Diphosphate Ribose; Recovery of Function; Signal Transduction; Spinal Cord Injuries; Tyrosine | 2006 |
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Carcinoma, Renal Cell; Humans; Immunohistochemistry; Kidney Neoplasms; Middle Aged; Neoplasm Staging; Nephrectomy; Oxidative Stress; Peroxidases; Peroxiredoxins; Prognosis; Survival Analysis; Tyrosine | 2006 |
HIV-1-induced pulmonary oxidative and nitrosative stress: exacerbated response to endotoxin administration in HIV-1 transgenic mouse model.
Topics: Animals; Cytokines; Glutathione; HIV Infections; HIV-1; Hydrogen Peroxide; Lipopolysaccharides; Lung; Mice; Mice, Transgenic; Nitrates; Nitrites; Nitrosation; Oxidative Stress; Pulmonary Edema; Tyrosine | 2006 |
Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase.
Topics: Acetylcholine; Aldehydes; Animals; Aorta, Thoracic; Arthritis, Experimental; Biopterins; Endothelium, Vascular; In Vitro Techniques; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilation | 2006 |
Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy.
Topics: Animals; Apoptosis; Arthropathy, Neurogenic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Isoquinolines; Male; Neural Conduction; Neurons; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Quinolines; Rats; Rats, Wistar; Streptozocin; Tyrosine | 2006 |
Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway.
Topics: Animals; Animals, Newborn; Biotin; Blotting, Western; Caspases; Enzyme Inhibitors; Female; Guanidines; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Pregnancy; Rats; Rats, Wistar; Sex Characteristics; Signal Transduction; Tyrosine | 2007 |
Effect of inhibition of nitric oxide synthase on renal cyclooxygenase in the diabetic rat.
Topics: Angiotensin II; Animals; Arachidonic Acid; Blood Pressure; Blotting, Western; Body Weight; Cyclooxygenase 1; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Enzyme Inhibitors; In Vitro Techniques; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Perfusion; Pressure; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 2006 |
Long-term progestin-only contraceptives result in reduced endometrial blood flow and oxidative stress.
Topics: Adult; Biopsy; Contraceptive Agents, Female; Desogestrel; Dinoprost; Endometrium; Endothelial Cells; Female; Humans; Immunohistochemistry; Laser-Doppler Flowmetry; Oxidative Stress; Progesterone Congeners; Tyrosine; Uterine Hemorrhage | 2006 |
The effects of chronic exposure to ethanol and cigarette smoke on the formation of peroxynitrite, level of nitric oxide, xanthine oxidase and myeloperoxidase activities in rat kidney.
Topics: Animals; Epithelial Cells; Ethanol; Immunohistochemistry; Inhalation Exposure; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Leukocytes, Mononuclear; Male; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Smoking; Tyrosine; Xanthine Oxidase | 2006 |
Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Aromatic-L-Amino-Acid Decarboxylases; Cell Death; Cell Line, Tumor; Cell Physiological Phenomena; Cell Survival; Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Humans; Mesencephalon; Microtubules; Monoamine Oxidase; Neurons; Nitrophenols; PC12 Cells; Phenylacetates; Rats; Tubulin; Tyrosine | 2006 |
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic Therapy; Liver; Metalloporphyrins; Mice; Mice, Inbred Strains; Mice, Transgenic; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Pterins; Reperfusion Injury; Severity of Illness Index; Tyrosine | 2006 |
Intracerebral hemorrhage elicits aberration in cardiomyocyte contractile function and intracellular Ca2+ transients.
Topics: Animals; Calcium Signaling; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cerebral Hemorrhage; Collagenases; Female; Gene Expression Regulation; Heart Diseases; Hypoxia-Inducible Factor 1, alpha Subunit; I-kappa B Proteins; Kv1.2 Potassium Channel; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide Synthase Type II; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Calcium Exchanger; Time Factors; Tyrosine | 2006 |
Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis.
Topics: Adult; Endothelium, Lymphatic; Endothelium, Vascular; Female; Fetal Hypoxia; Humans; Immunoenzyme Techniques; Infant; Infant, Newborn; Lung; Lung Diseases; Lymphangiectasis; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Pregnancy; Reference Values; Tyrosine | 2006 |
Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.
Topics: Adenoma; Adult; Amino Acid Sequence; Chromatography, Affinity; Humans; Male; Molecular Sequence Data; Multiprotein Complexes; Neoplasm Proteins; Nitrogen; Pituitary Neoplasms; Protein Structure, Tertiary; Proteomics; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2006 |
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism.
Topics: Animals; Arginase; Atherosclerosis; Bromodeoxyuridine; Cell Movement; Disease Models, Animal; Estradiol; Female; Gene Expression Regulation, Enzymologic; Hyperlipidemias; Immunohistochemistry; Lipids; Macrophages; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Rabbits; Tyrosine | 2006 |
Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspases; Excitatory Amino Acid Agonists; Immunoenzyme Techniques; Immunohistochemistry; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Retina; Retinal Diseases; Retinal Ganglion Cells; Thioredoxins; Tyrosine | 2006 |
Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.
Topics: Aldehydes; Animals; Antipyrine; Apolipoproteins E; Apoptosis; Atherosclerosis; Cells, Cultured; Cholesterol, Dietary; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Endothelial Cells; Free Radical Scavengers; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2007 |
Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis.
Topics: Airway Obstruction; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Female; Fibrinolytic Agents; Infusions, Intravenous; Lung; Nitrates; Nitrites; Organ Size; Prospective Studies; Protein C; Pulmonary Edema; Random Allocation; Recombinant Proteins; Respiratory Function Tests; Sepsis; Sheep; Smoke Inhalation Injury; Tyrosine | 2006 |
Modifications of platelet from Alzheimer disease patients: a possible relation between membrane properties and NO metabolites.
Topics: Aged; Alzheimer Disease; Blood Platelets; Calcium; Diphenylhexatriene; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2007 |
A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock.
Topics: Amidines; Animals; Benzylamines; Endothelium, Vascular; Liver; Male; Metalloporphyrins; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Shock, Septic; Tyrosine; Vasoconstriction | 2006 |
Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cadherins; Carbon Tetrachloride Poisoning; Cholangiocarcinoma; Cyclooxygenase 2; Extracellular Matrix; Female; Fibrosis; Germ-Line Mutation; Hyperplasia; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-met; Receptor, ErbB-2; Tumor Suppressor Protein p53; Tyrosine | 2006 |
Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass.
Topics: Aged; Apoptosis; Apoptosis Inducing Factor; Atrial Appendage; bcl-Associated Death Protein; Blood; Cardiopulmonary Bypass; Caspase 3; Caspases; Cell Hypoxia; Female; Gene Expression Profiling; Heart Arrest, Induced; Humans; In Situ Nick-End Labeling; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Myocardial Reperfusion; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Tyrosine | 2006 |
Oxidative stress time course in the rat diaphragm after freezing-thawing cycles.
Topics: Animals; Blotting, Western; Catalase; Diaphragm; Freezing; Gene Expression Regulation; Hypothermia; Immunohistochemistry; In Vitro Techniques; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Time Factors; Tyrosine | 2007 |
Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation.
Topics: Animals; Biopterins; Male; Mice; Mice, Inbred C57BL; Microcirculation; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Transplantation, Homologous; Tyrosine | 2006 |
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Resistance; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Imines; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2006 |
Nitrotyrosine in brain tissue of neonates after perinatal asphyxia.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Asphyxia Neonatorum; Autopsy; Brain Chemistry; Caspase 3; Female; Humans; Infant, Newborn; Male; Tyrosine | 2006 |
Manganese enhances peroxynitrite and leukotriene E4 formation in bovine aortic endothelial cells exposed to arsenic.
Topics: Animals; Aorta; Arsenic; Arsenites; Cattle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Endothelium, Vascular; Environmental Pollutants; Enzyme Inhibitors; Leukotriene E4; Manganese; NG-Nitroarginine Methyl Ester; Peroxynitrous Acid; Sodium Compounds; Tyrosine | 2006 |
Immunohistochemical evidence of inducible nitric oxide synthase and nitrotyrosine in a case of clinically isolated optic neuritis.
Topics: Astrocytes; Biomarkers; Cyclooxygenase 2; Disease Progression; Humans; Immunohistochemistry; In Vitro Techniques; Male; Microglia; Myelin Basic Protein; Nitric Oxide Synthase Type II; Optic Neuritis; Prognosis; Tyrosine | 2006 |
Simvastatin improves diabetes-induced coronary endothelial dysfunction.
Topics: Animals; Arginine; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Streptozocin; Superoxides; Tyrosine; Vasodilation | 2006 |
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
Topics: Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hesperidin; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injury.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Dinoprost; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroprusside; Tyrosine | 2006 |
gamma-tocopherol, but not alpha-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats.
Topics: Acridines; alpha-Tocopherol; Animals; Antioxidants; Blood Pressure; gamma-Tocopherol; Insulin; Insulin Resistance; Male; Muscle, Smooth, Vascular; Oxidative Stress; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Tunica Intima; Tyrosine; Vascular Diseases; Vitamin E | 2006 |
Decreased endothelium-dependent vasodilation in diabetic female rats: role of prostanoids.
Topics: Acetylcholine; Animals; Arterioles; Bradykinin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Female; Histamine; Mesenteric Arteries; Nitric Oxide; Prostaglandins; Rats; Rats, Wistar; Superoxides; Tyrosine; Vasodilation | 2006 |
Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints.
Topics: Animals; Bone and Bones; Cartilage, Articular; Horses; Metacarpophalangeal Joint; Nitrites; Osteoarthritis, Knee; Tyrosine | 2006 |
Protein nitration increased by simulated weightlessness and decreased by melatonin and quercetin in PC12 cells.
Topics: Animals; Melatonin; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; PC12 Cells; Quercetin; Rats; Tyrosine; Weightlessness Simulation | 2006 |
Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Catalase; Deoxyguanosine; Female; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Immunohistochemistry; Insecticides; Methoxychlor; Mice; Mitochondria; Ovarian Diseases; Ovary; Oxidants; Oxidative Stress; Oxygen Consumption; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2006 |
Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Apoptosis; Biopterins; Caspase 3; Cells, Cultured; Deoxyguanosine; Endothelial Cells; Glucose; Humans; Hyperglycemia; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-bcl-2; Superoxides; Thenoyltrifluoroacetone; Tyrosine | 2007 |
Plasma levels of nitrites, PGF1alpha, and nitrotyrosine in LPS-treated rats: functional and histochemical implications in aorta.
Topics: Animals; Aorta; Enzyme Inhibitors; Indomethacin; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Phenylephrine; Prostaglandins F; Rats; Rats, Wistar; Tyrosine; Vasoconstriction | 2006 |
Protein nitration with aging in the rat semimembranosus and soleus muscles.
Topics: Aging; Animals; Male; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred F344; Tyrosine | 2006 |
Electromyographic findings in nucleus pulposus-induced radiculopathy in the rat.
Topics: Animals; Disease Models, Animal; Electromyography; Fluorescent Antibody Technique, Indirect; Ganglia, Spinal; Hyperalgesia; Immunoenzyme Techniques; Intervertebral Disc; Male; Muscle, Skeletal; Paresis; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Tyrosine | 2006 |
Oxidative imbalance in the aging inner ear.
Topics: Aging; Aldehydes; Animals; Apoptosis Inducing Factor; Biomarkers; Cochlea; Free Radicals; Hair Cells, Auditory; Male; Mice; Mice, Inbred CBA; Nerve Degeneration; Neurons, Afferent; Organ of Corti; Oxidative Stress; Spiral Ganglion; Superoxide Dismutase; Tyrosine | 2007 |
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thioredoxins; Tyrosine | 2006 |
CXCR2 blockade reduces radical formation in hyperoxia-exposed newborn rat lung.
Topics: Animals; Animals, Newborn; Dinoprost; Hydroxyl Radical; Hyperoxia; Lung; Neutrophils; Oxygen; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Receptors, Interleukin-8B; Tyrosine | 2006 |
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Disease Models, Animal; Gene Deletion; Guanidines; Humans; Hydrogen Peroxide; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Pyruvate Oxidase; Streptococcus pneumoniae; Tyrosine | 2006 |
Short term protective effects of iron in a murine model of ischemia/reperfusion.
Topics: Animals; Iron; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Free 3-nitrotyrosine in exhaled breath condensates of children fails as a marker for oxidative stress in stable cystic fibrosis and asthma.
Topics: Adolescent; Adult; Asthma; Biomarkers; Breath Tests; Child; Child, Preschool; Cystic Fibrosis; Exhalation; Female; Humans; Male; Middle Aged; Oxidative Stress; Tyrosine | 2006 |
Diaphragmatic nitric oxide synthase is not induced during mechanical ventilation.
Topics: Animals; Diaphragm; Enzyme Induction; Female; Free Radicals; Glutathione; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Tyrosine | 2007 |
Nitration enhances the allergenic potential of proteins.
Topics: Allergens; Animals; Antigens, Plant; Cell Proliferation; Female; Food Hypersensitivity; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Proteins; Protein Processing, Post-Translational; Spleen; Tetranitromethane; Tyrosine | 2006 |
Tyrosine nitration: who did it, and how do we prove it? A commentary on "pH dependent nitration of para-hydroxyphenylacetic acid in the stomach".
Topics: Acrylates; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Nitric Oxide; Phenols; Tyrosine | 2006 |
pH-dependent nitration of para-hydroxyphenylacetic acid in the stomach.
Topics: Acrylates; Adult; Female; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Middle Aged; Nitrates; Nitric Oxide; Phenols; Reference Values; Tyrosine | 2006 |
Gastric expression of inducible nitric oxide synthase and myeloperoxidase in relation to nitrotyrosine in Helicobacter pylori-infected Mongolian gerbils.
Topics: Animals; Blotting, Western; Disease Models, Animal; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Nitric Oxide Synthase Type II; Peroxidase; Pyloric Antrum; Pylorus; Rats; Severity of Illness Index; Tyrosine | 2006 |
Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway.
Topics: Animals; Apoptosis; Blood Pressure; Blotting, Western; Cell Nucleus; Creatine; Cyclooxygenase 2; DNA Fragmentation; Gene Expression Regulation, Enzymologic; Genetic Vectors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension, Renovascular; Kidney Diseases; Protoporphyrins; Rats; Rats, Sprague-Dawley; Renal Artery; Retroviridae; RNA, Antisense; Signal Transduction; Tyrosine | 2007 |
Improved tandem mass spectrometric characterization of 3-nitrotyrosine sites in peptides.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Oxidation-Reduction; Peptide Mapping; Peptides; Serum Albumin, Bovine; Tandem Mass Spectrometry; Tyrosine | 2006 |
Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity.
Topics: Age Factors; Autopsy; Chronic Disease; Humans; Immunohistochemistry; Infant, Newborn; Infant, Premature; Lung; Lung Diseases; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Severity of Illness Index; Tyrosine | 2006 |
Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia.
Topics: Adult; Amino Acid Sequence; Catalysis; Female; Gestational Age; Humans; Molecular Sequence Data; Molecular Weight; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Placenta; Pre-Eclampsia; Pregnancy; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
pH profile of cytochrome c-catalyzed tyrosine nitration.
Topics: Animals; Biomarkers; Catalysis; Cattle; Cytochromes c; Hydrogen Peroxide; Hydrogen-Ion Concentration; Nitrates; Nitrites; Oxidants; Oxidation-Reduction; Reactive Nitrogen Species; Serum Albumin, Bovine; Tyrosine | 2006 |
Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose.
Topics: Antioxidants; Apoptosis; Cells, Cultured; Female; Gliclazide; Glucose; Glyburide; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Microscopy, Electron; Middle Aged; Tyrosine | 2007 |
Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice.
Topics: Animals; Atherosclerosis; Down-Regulation; Flavonoids; Glycosides; Inflammation; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Receptors, LDL; Sinus of Valsalva; Tissue Distribution; Tyrosine | 2006 |
Effects of prenatal lipopolysaccharide exposure on epithelial development and function in newborn rat intestine.
Topics: Animals; Animals, Newborn; Dextrans; Female; Fluorescein-5-isothiocyanate; Ileum; Immunohistochemistry; Intestinal Mucosa; Intestines; Lipopolysaccharides; Nitric Oxide Synthase Type II; Permeability; Pregnancy; Pregnancy Complications, Infectious; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Protection against myocardial ischemia/reperfusion injury by short-term diabetes: enhancement of VEGF formation, capillary density, and activation of cell survival signaling.
Topics: Animals; Blood Pressure; Blotting, Western; Capillaries; Caspase 3; Cell Survival; Coronary Circulation; Diabetes Mellitus, Experimental; Heart Rate; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Myocardium; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Signal Transduction; Tyrosine; Vascular Endothelial Growth Factor A | 2006 |
Neuroprotection by selective inhibition of inducible nitric oxide synthase after experimental brain contusion.
Topics: Animals; Apoptosis; Brain Injuries; Cell Survival; Disease Models, Animal; Female; Lysine; Nerve Degeneration; Neurons; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Deoxyguanosine; Disease Models, Animal; Fatty Acids, Nonesterified; Hypertension; Inflammation; Insulin; Male; Metabolic Syndrome; Molecular Structure; Musa; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Inbred SHR; Thiobarbituric Acid Reactive Substances; Triglycerides; Triterpenes; Tyrosine | 2006 |
Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.
Topics: Animals; Antioxidants; Apoptosis; bcl-X Protein; Blood Pressure; Blotting, Western; Diabetic Angiopathies; Endothelial Cells; Heme Oxygenase (Decyclizing); Hypertension; Male; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxygen; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Zucker; Signal Transduction; Tyrosine; Up-Regulation | 2006 |
Coexpression of NRAMP1, iNOS, and nitrotyrosine in bovine tuberculosis.
Topics: Animals; Cation Transport Proteins; Cattle; Female; Gene Expression Regulation, Enzymologic; Granuloma; Lung; Lymph Nodes; Nitric Oxide Synthase Type II; Tuberculosis, Bovine; Tyrosine | 2006 |
Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro.
Topics: Analysis of Variance; Antioxidants; Blood Platelets; Conyza; Humans; In Vitro Techniques; Oxidative Stress; Peroxynitrous Acid; Plant Extracts; Platelet Aggregation; Protein Carbonylation; Tyrosine | 2006 |
A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice.
Topics: Amidines; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cytokines; Drug Administration Schedule; Enzyme Inhibitors; Heterocyclic Compounds, 2-Ring; Hyperoxia; Immunohistochemistry; Injections, Subcutaneous; Lung; Lung Diseases; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitrogen Oxides; Tyrosine | 2007 |
The antagonism of cholecystokinin octapeptide-8 to the peroxynitrite oxidation on a diabetic cataractal rat model.
Topics: Animals; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Male; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide; Streptozocin; Tyrosine | 2006 |
Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Aged, 80 and over; Aldehydes; Base Pair Mismatch; Breast Neoplasms; Carrier Proteins; Deoxyguanosine; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Middle Aged; Nuclear Proteins; Oxidative Stress; Tyrosine | 2006 |
Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.
Topics: Aldehydes; Animals; Antioxidants; Bisoprolol; Blood Pressure; Body Weight; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Echocardiography; Fibrosis; Glutathione; Heart Failure; Heart Rate; Interleukin-1; Isoenzymes; Male; NADPH Oxidases; Organ Size; Oxidative Stress; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Ventricular Function, Left | 2006 |
Generation and release of nitrotyrosine O-sulfate by HepG2 human hepatoma cells upon SIN-1 stimulation: identification of SULT1A3 as the enzyme responsible.
Topics: Arylsulfotransferase; Carcinoma, Hepatocellular; Cell Line, Tumor; Dopamine; Humans; Kinetics; Molsidomine; Sulfotransferases; Tyrosine | 2007 |
Hydroxylation of 3-nitrotyrosine and its derivatives by gamma irradiation.
Topics: Dose-Response Relationship, Radiation; Gamma Rays; Hydroxyl Radical; Hydroxylation; Radiation Dosage; Tyrosine | 2006 |
Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension.
Topics: Animals; Animals, Newborn; Female; Humans; Infant, Newborn; Isoprostanes; Lung; Male; Nitric Oxide; Norepinephrine; Oxidation-Reduction; Oxygen; Persistent Fetal Circulation Syndrome; Potassium Chloride; Pulmonary Artery; Reactive Oxygen Species; Recombinant Proteins; Sheep; Superoxide Dismutase; Tyrosine; Vasoconstriction | 2006 |
Effects of trapidil on renal ischemia-reperfusion injury.
Topics: Animals; Kidney; Malondialdehyde; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Trapidil; Tumor Necrosis Factor-alpha; Tyrosine; Vasodilator Agents | 2006 |
The effects of reactive oxygen and nitrogen species during yeast replicative ageing.
Topics: alpha-Tocopherol; Cell Division; Enzyme-Linked Immunosorbent Assay; Lipofuscin; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Saccharomyces cerevisiae; Tyrosine | 2006 |
The effect of plant cytokinin hormones on the production of ethylene, nitric oxide, and protein nitrotyrosine in ageing tobacco leaves.
Topics: Cytokinins; Ethylenes; Gene Expression Regulation, Plant; Nicotiana; Nitric Oxide; Plant Growth Regulators; Plant Leaves; Plants, Genetically Modified; Tyrosine | 2006 |
Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary omega-6 polyunsaturated fatty acids.
Topics: Animals; Blotting, Western; Diet; DNA, Mitochondrial; Fatty Acids, Omega-6; Fluorescent Antibody Technique; Gene Expression; Heart Diseases; Lipid Peroxides; Male; Mitochondria, Heart; Nitric Oxide Synthase Type II; Oxidative Stress; Phospholipases A; Plant Oils; Rats; Rats, Wistar; Sunflower Oil; Superoxide Dismutase; Tyrosine | 2006 |
Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite.
Topics: Animals; Atherosclerosis; Cells, Cultured; Endothelium, Vascular; Female; Humans; Hypochlorous Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxygen; Peroxidase; Peroxynitrous Acid; Phosphoproteins; Superoxides; Tyrosine; Uncoupling Agents | 2006 |
Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma.
Topics: Adult; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulins; Ligands; Male; Reproducibility of Results; Respiratory Distress Syndrome; Risk Factors; Tyrosine; Wounds and Injuries | 2007 |
TNF-alpha potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells.
Topics: Animals; Aorta; beta-Cyclodextrins; Cattle; Caveolae; Cells, Cultured; Cholesterol; Endothelial Cells; Enzyme Activation; Membrane Microdomains; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Transport; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Measurement and significance of 3-nitrotyrosine in systemic lupus erythematosus.
Topics: Adolescent; Adult; Autoantibodies; Blotting, Western; Case-Control Studies; Chromatography, High Pressure Liquid; DNA; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Middle Aged; Protein Binding; Reactive Nitrogen Species; Tyrosine | 2006 |
Peroxynitrite diminishes myogenic tone in cerebral arteries: role of nitrotyrosine and F-actin.
Topics: Actins; Animals; Dithiothreitol; Dose-Response Relationship, Drug; Glyburide; Immunohistochemistry; In Vitro Techniques; Male; Microscopy, Confocal; Oxidation-Reduction; Peroxynitrous Acid; Posterior Cerebral Artery; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Sulfhydryl Compounds; Tetraethylammonium; Time Factors; Tyrosine; Vasodilation | 2007 |
Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.
Topics: Actins; Animals; Antioxidants; Apoptosis; Cardiomyopathies; Caspase 3; Cell Death; Cytochromes c; Diabetes Mellitus, Experimental; Enzyme Activation; Glutathione; Glutathione Disulfide; Lipid Peroxidation; Metallothionein; Mice; Mice, Transgenic; Mitochondria, Heart; Myocardium; Myocytes, Cardiac; Oxidative Stress; Sarcomeres; Survival Analysis; Tyrosine | 2006 |
Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan.
Topics: Animals; Apoptosis; Fas Ligand Protein; Inflammation; Intestines; Kidney; Lipid Peroxidation; Mice; Mice, Knockout; Multiple Organ Failure; Neutrophil Infiltration; Nitric Oxide; PPAR alpha; Shock; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Zymosan | 2006 |
Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Fas Ligand Protein; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Motor Neurons; Nitric Oxide Synthase Type I; Probability; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tyrosine | 2006 |
Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation.
Topics: Anti-Inflammatory Agents; Humans; Inflammation; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides; Tyrosine | 2006 |
Cellular senescence in honey bee brain is largely independent of chronological age.
Topics: Age Factors; Animals; Bees; Behavior, Animal; Blotting, Western; Brain; Cellular Senescence; Female; Immunohistochemistry; Models, Animal; Oxidative Stress; Protein Carbonylation; Tyrosine | 2006 |
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease.
Topics: Aldehydes; Alzheimer Disease; Animals; Antioxidants; Behavior Therapy; Behavior, Animal; Brain; Disease Models, Animal; Dogs; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Glutathione Transferase; Heme Oxygenase-1; Proteomics; Superoxide Dismutase; Tyrosine | 2008 |
Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo.
Topics: Animals; Aorta; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Endothelium, Vascular; Epoprostenol; Humans; Hyperglycemia; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitric Oxide Synthase Type III; Reactive Nitrogen Species; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation | 2006 |
Calorie restriction improves cardiovascular risk factors via reduction of mitochondrial reactive oxygen species in type II diabetic rats.
Topics: Animals; Body Weight; Caloric Restriction; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Glucose Transporter Type 4; Ion Channels; Lipid Peroxidation; Male; Mitochondria; Mitochondrial Proteins; Nitric Oxide Synthase Type III; Organ Size; Plasminogen Activator Inhibitor 1; Rats; Rats, Long-Evans; Reactive Oxygen Species; Risk Factors; Tyrosine; Uncoupling Protein 2 | 2007 |
Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI)--2',3'-dideoxycytidine (ddC): relevance to HIV-dementia.
Topics: AIDS Dementia Complex; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bridged-Ring Compounds; Caspase 3; Cerebral Cortex; Cytochromes c; Disease Progression; Gerbillinae; Humans; Lamivudine; Male; Mitochondria; Nerve Tissue Proteins; Neuroprotective Agents; Norbornanes; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Inhibitors; Synaptosomes; Thiocarbamates; Thiones; Tyrosine; Zalcitabine | 2007 |
The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy.
Topics: Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Immunohistochemistry; Male; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Protein tyrosine nitration induced by heme/hydrogen peroxide: inhibitory effect of hydroxycinnamoyl conjugates.
Topics: Asteraceae; Catalysis; Coumaric Acids; Heme; Hemeproteins; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Leukocytes; Nitrates; Phytotherapy; Tyrosine | 2007 |
Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults.
Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cell Adhesion; Endothelium, Vascular; Energy Intake; Exercise; Fasting; Female; Humans; Intercellular Adhesion Molecule-1; Life Style; Male; Obesity; Phospholipases A; Phospholipases A2; Tyrosine | 2006 |
Oxidative stress in the metabolic syndrome.
Topics: Adult; Blood Glucose; Blood Pressure; Brachial Artery; Case-Control Studies; Female; Humans; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Oxidative Stress; Regional Blood Flow; Tyrosine; Vasodilation | 2006 |
The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction.
Topics: Acetylcholine; Aging; Animals; Aorta; Diastole; Endothelium, Vascular; Heart Diseases; In Vitro Techniques; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Tyrosine; Vasodilation; Ventricular Function, Left | 2007 |
Posttranslational nitrotyrosination of alpha-tubulin induces cell cycle arrest and inhibits proliferation of vascular smooth muscle cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cells, Cultured; Glutamic Acid; Microtubules; Muscle, Smooth, Vascular; Protein Processing, Post-Translational; Rats; Tubulin; Tyrosine | 2006 |
A comparative study of proteolysis methods for the measurement of 3-nitrotyrosine residues: enzymatic digestion versus hydrochloric acid-mediated hydrolysis.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Enzymes; Humans; Hydrochloric Acid; Hydrolysis; Rats; Serum Albumin, Bovine; Time Factors; Tyrosine | 2007 |
Protective effects of propofol on lipopolysaccharide-activated endothelial cell barrier dysfunction.
Topics: Actins; Cells, Cultured; Endothelial Cells; Free Radical Scavengers; Humans; Lipopolysaccharides; NF-kappa B; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Permeability; Propofol; RNA, Messenger; Tyrosine; Umbilical Cord | 2006 |
Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats.
Topics: Animals; Behavior, Animal; Cell Count; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Drug Interactions; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Indans; Injections, Intraventricular; Male; Memory Disorders; Oxidative Stress; Rats; Rats, Sprague-Dawley; Streptozocin; Tyrosine; Vesicular Acetylcholine Transport Proteins | 2007 |
Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response.
Topics: Aldehydes; Animals; Autoantibodies; Environmental Pollutants; Female; Lipid Peroxidation; Liver; Malondialdehyde; Mice; Mice, Inbred MRL lpr; Nitric Oxide Synthase Type II; Ovalbumin; Oxidative Stress; Solvents; Trichloroethylene; Tyrosine | 2007 |
Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathway.
Topics: Animals; Apoptosis; Blotting, Western; Heme Oxygenase (Decyclizing); Mitochondria; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase; Tyrosine; Voltage-Dependent Anion Channel 1 | 2007 |
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Cerebrovascular Circulation; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilator Agents; Vibrissae | 2007 |
Effects of eicosapentaenoic acid on the early stage of type 2 diabetic nephropathy in KKA(y)/Ta mice: involvement of anti-inflammation and antioxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Chemokine CCL2; Collagen Type I; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Eicosapentaenoic Acid; Lipid Peroxidation; Macrophages; Male; Mice; Oxidative Stress; Phenotype; Transforming Growth Factor beta1; Tyrosine | 2006 |
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Fetus; HSP90 Heat-Shock Proteins; Humans; Infant, Newborn; Ligation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxidative Stress; Persistent Fetal Circulation Syndrome; Pregnancy; Pulmonary Artery; S-Nitroso-N-Acetylpenicillamine; Sheep; Superoxides; Tyrosine; Vasodilation | 2007 |
In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidativ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Brain; Bridged-Ring Compounds; Cytochromes c; Gerbillinae; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Injections, Intraperitoneal; Lipid Peroxidation; Male; Mitochondria; Neurodegenerative Diseases; Neuroprotective Agents; Norbornanes; Oxidation-Reduction; Oxidative Stress; Thiocarbamates; Thiones; Type C Phospholipases; Tyrosine | 2006 |
NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure.
Topics: Acute Kidney Injury; Aged; Base Sequence; Biomarkers; Catalase; Cohort Studies; DNA Primers; Female; Genetic Variation; Genotype; Humans; Length of Stay; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Prospective Studies; Renal Replacement Therapy; Tyrosine | 2007 |
Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: sparing effects of chlorogenic acid and serum albumin.
Topics: Animals; Ascorbic Acid; Chlorogenic Acid; Humans; Hydrogen-Ion Concentration; Nitric Oxide; Nitrogen Dioxide; Oxygen; Reactive Nitrogen Species; Saliva; Serum Albumin, Bovine; Stomach; Tyrosine; Uric Acid | 2006 |
Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions.
Topics: alpha-Tocopherol; Animals; Antioxidants; Caspase 3; Chromans; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Male; Molecular Structure; Neuroprotective Agents; Neutrophil Activation; Neutrophils; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2007 |
Time-dependent expression pattern of nitric oxide and superoxide after myocardial infarction in rats.
Topics: Animals; Enzyme Activation; Immunohistochemistry; Kinetics; Male; Myocardial Infarction; Myocardium; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxynitrous Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxides; Time Factors; Tyrosine | 2007 |
The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets.
Topics: Blood Platelets; Humans; Lipopolysaccharides; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Platelet Activating Factor; Platelet Activation; Proteus mirabilis; Thrombin; Tyrosine | 2007 |
Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections.
Topics: Acute Disease; Arginine; Bacterial Infections; Biomarkers; Blood Pressure; C-Reactive Protein; Calcitonin; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Creatinine; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycoproteins; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Nitric Oxide Synthase; Protein Precursors; Severity of Illness Index; Tyrosine | 2007 |
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
Topics: Acute Disease; Animals; Arthritis, Experimental; Hindlimb; Hyperalgesia; Injections, Intra-Articular; Knee Joint; Male; Neutrophils; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Tyrosine; Uric Acid; Zymosan | 2007 |
Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain.
Topics: Animals; Brain; Carbon Monoxide; Dipeptides; Doxorubicin; Glutathione; Glutathione Transferase; Male; Mice; Mice, Inbred Strains; Models, Animal; Oxidative Stress; Tyrosine | 2007 |
Puerarin decreases lens epithelium cell apoptosis induced partly by peroxynitrite in diabetic rats.
Topics: Animals; Apoptosis; Cataract; Diabetes Mellitus, Experimental; Epithelial Cells; Isoflavones; Lens, Crystalline; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Tyrosine | 2006 |
Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Disease Models, Animal; Disease Progression; Gliosis; Mice; Mice, Transgenic; Psychomotor Performance; Pyruvic Acid; Spinal Cord; Superoxide Dismutase; Survival Analysis; Tyrosine | 2007 |
Nitrotyrosine formation and heme oxygenase-1 expression in endotoxemic cirrhotic rats.
Topics: Animals; Endotoxemia; Heme Oxygenase-1; Lipid Peroxidation; Lipopolysaccharides; Liver; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Thioacetamide; Tyrosine | 2007 |
Role of peroxynitrite in secondary oxidative damage after spinal cord injury.
Topics: Aldehydes; Animals; Biomarkers; Calcium Signaling; Calpain; Disease Progression; Female; Free Radical Scavengers; Free Radicals; Lipid Peroxidation; Nerve Degeneration; Nitric Oxide; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spectrin; Spinal Cord Injuries; Time Factors; Tyrosine; Up-Regulation | 2007 |
Effects of testosterone on differentiation and oxidative stress resistance in C1300 neuroblastoma cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Shape; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Stem Cells; Testosterone; Tyrosine | 2006 |
Kurozu moromimatsu inhibits tumor growth of Lovo cells in a mouse model in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Female; Fermentation; Metalloproteases; Mice; Mice, Nude; Neoplasm Transplantation; Oryza; Phytotherapy; Plant Extracts; Random Allocation; Specific Pathogen-Free Organisms; Tyrosine | 2007 |
Nitric oxide production in the ventilatory muscles in response to acute resistive loading.
Topics: Airway Resistance; Animals; Cytoplasmic Dyneins; Diaphragm; Dyneins; Endothelins; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Tyrosine | 2007 |
Establishment of a sandwich ELISA using commercial antibody for plasma or serum 3-nitrotyrosine (3NT). Elevation in inflammatory diseases and complementary between 3NT and myeloperoxidase.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Mice; Peroxidase; Reagent Kits, Diagnostic; Reference Values; Tyrosine | 2007 |
Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides.
Topics: Animals; Apoptosis; Free Radical Scavengers; Free Radicals; Motor Neurons; PC12 Cells; Peptides; Peroxynitrous Acid; Rats; Tyrosine | 2007 |
Light-induced changes in protein nitration in photoreceptor rod outer segments.
Topics: Animals; Antioxidants; Blotting, Western; Chromatography, Liquid; Darkness; Eye Proteins; Light; Male; Nitrates; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Rod Cell Outer Segment; Tandem Mass Spectrometry; Thiourea; Tyrosine | 2006 |
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.
Topics: Animals; Disease Models, Animal; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury; Tyrosine; Xanthine Dehydrogenase | 2007 |
Nitration of specific tyrosine residues of cytochrome C is associated with caspase-cascade inactivation.
Topics: 5-Methoxytryptamine; Animals; Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytochromes c; Enzyme Activation; Free Radical Scavengers; Nitrosation; Peptide Mapping; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin; Tyrosine | 2007 |
The nitric oxide donor LA 419 decreases ischemic brain damage.
Topics: Animals; Brain Ischemia; Calcium; Disease Models, Animal; Immunohistochemistry; Isosorbide Dinitrate; Magnetic Resonance Imaging; Male; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tyrosine | 2007 |
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
Topics: Acetylcarnitine; Aldehydes; Alzheimer Disease; Animals; Apoptosis; Cell Survival; Cerebral Cortex; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Lipid Peroxidation; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Thioctic Acid; Tyrosine | 2007 |
Role of peroxynitrite in endothelial damage mediated by Cyclosporine A.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Endothelial Cells; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets.
Topics: Adenosine Triphosphatases; Animals; Animals, Newborn; Blotting, Western; Corpus Striatum; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Hypoxia-Ischemia, Brain; Immunohistochemistry; Microdialysis; Neurons; Neuroprotective Agents; Phosphorylation; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Swine; Tyrosine | 2007 |
Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars.
Topics: Alkaline Phosphatase; Animals; Dental Pulp; Dentin; Gene Expression Regulation, Enzymologic; Male; Molar; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Odontoblasts; Osteocalcin; Protein Transport; Rats; Rats, Wistar; RNA, Messenger; Tooth Preparation; Tyrosine; Wound Healing | 2007 |
Circumferential wall tension due to hypertension plays a pivotal role in aorta remodelling.
Topics: Animals; Aorta, Abdominal; Aortic Valve Stenosis; Biomarkers; Hypertension; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Models, Animal; Models, Cardiovascular; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulsatile Flow; Rats; Rats, Wistar; Stress, Mechanical; Transforming Growth Factor beta; Tunica Intima; Tyrosine; Ultrasonography, Doppler, Color | 2006 |
Expression of cyclooxygenase-2, alpha 1-acid-glycoprotein and inducible nitric oxide synthase in the developing lesions of murine leprosy.
Topics: Animals; Chronic Disease; Cyclooxygenase 2; Female; Granuloma; Immunohistochemistry; Leprosy; Mice; Mice, Inbred Strains; Models, Animal; Mycobacterium lepraemurium; Nitric Oxide Synthase Type II; Orosomucoid; Staining and Labeling; Tyrosine | 2006 |
Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress.
Topics: Acute Disease; Animals; Doxorubicin; Heart Diseases; Iridoid Glucosides; Iridoids; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase Type II; Nitrosation; Oleaceae; Oxidative Stress; Pyrans; Rats; Rats, Wistar; Tyrosine | 2007 |
Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-A(y)/Ta mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Immunohistochemistry; Laminin; Lysine; Male; Mice; Pyridoxamine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schiff Bases; Transforming Growth Factor beta1; Tyrosine | 2007 |
Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain.
Topics: Animals; Antibiotics, Antineoplastic; Blotting, Western; Brain Chemistry; Central Nervous System; Doxorubicin; Electrophoresis, Gel, Two-Dimensional; Enzyme-Linked Immunosorbent Assay; Gene Expression; Male; Mice; Mice, Knockout; Mitochondria; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteins.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucaric Acid; Glutathione; Homocysteine; Humans; Hydrogen Peroxide; Molecular Weight; Nitrites; Oxidation-Reduction; Sulfhydryl Compounds; Tyrosine | 2007 |
Determination of plasma free 3-nitrotyrosine and tyrosine by reversed-phase liquid chromatography with 4-fluoro-7-nitrobenzofurazan derivatization.
Topics: 4-Chloro-7-nitrobenzofurazan; Adult; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Indicators and Reagents; Male; Methyltyrosines; Oxidative Stress; Plasma; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Smoking; Spectrometry, Fluorescence; Tyrosine | 2007 |
The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model.
Topics: Animals; Brain Injuries; Corpus Striatum; Disease Models, Animal; Ischemia; Isosorbide Dinitrate; Magnetic Resonance Imaging; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine | 2007 |
Bidimensional tandem mass spectrometry for selective identification of nitration sites in proteins.
Topics: Amino Acid Sequence; Animals; Cattle; Dansyl Compounds; Milk; Milk Proteins; Molecular Sequence Data; Peptide Fragments; Proteins; Proteomics; Serum Albumin, Bovine; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2007 |
Effect of ischemic acute renal damage on the expression of COX-2 and oxidative stress-related elements in rat kidney.
Topics: Acute Kidney Injury; Animals; Cyclooxygenase 2; Erythropoietin; Heme Oxygenase-1; Ischemia; Kidney; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Renin; Tissue Distribution; Tyrosine | 2007 |
Astrocytes aged in vitro show a decreased neuroprotective capacity.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Heme Oxygenase-1; Hydrogen Peroxide; Nerve Growth Factors; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Reactive Oxygen Species; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2007 |
N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Apoptosis; Calpain; Caspases; Cystine; Enzyme Activation; Glutathione; Hypoxia-Ischemia, Brain; Isoprostanes; Lipopolysaccharides; Membrane Proteins; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Wistar; Thioredoxins; Tyrosine | 2007 |
Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging.
Topics: Aging; Amino Acid Sequence; Animals; Blotting, Western; Cerebellum; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Proteins; Proteomics; Rats; Rats, Inbred F344; Tyrosine | 2007 |
[Reduced expression of the sarcoplasmic calcium pump SERCA2 in skeletal muscle from patients with chronic obstructive pulmonary disease and low body weight].
Topics: Blood Gas Analysis; Body Mass Index; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Protein Processing, Post-Translational; Pulmonary Disease, Chronic Obstructive; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Smoking; Thinness; Tyrosine | 2007 |
Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel protocol for HPLC-ECD.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Electrochemistry; Electrophysiology; Injections, Intravenous; Lipopolysaccharides; Male; Plasma; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Tyrosine | 2007 |
S-nitrosoglutathione-containing hydrogel increases dermal blood flow in streptozotocin-induced diabetic rats.
Topics: Administration, Cutaneous; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Foot; Heart Rate; Hydrogel, Polyethylene Glycol Dimethacrylate; Laser-Doppler Flowmetry; Microcirculation; Nitric Oxide Donors; Rats; S-Nitrosoglutathione; Skin; Streptozocin; Tyrosine; Vasodilation; Vasodilator Agents | 2007 |
Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin.
Topics: Actins; Animals; Brain; Electrophoresis, Gel, Two-Dimensional; Intermediate Filament Proteins; Membrane Glycoproteins; Microtubules; Nerve Tissue Proteins; PC12 Cells; Peripherins; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2007 |
Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure.
Topics: Actins; Animals; Anti-Inflammatory Agents; Atrial Fibrillation; Biomarkers; Cardiac Pacing, Artificial; Cell Proliferation; Cells, Cultured; Dogs; Fenofibrate; Fibroblasts; Heart Atria; Heart Failure; Heart Ventricles; Hypolipidemic Agents; Models, Animal; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; PPAR alpha; Refractory Period, Electrophysiological; Simvastatin; Tyrosine; Ventricular Remodeling | 2007 |
Alpha-synuclein tertiary contact dynamics.
Topics: alpha-Synuclein; Amino Acid Sequence; Electron Transport; Molecular Sequence Data; Protein Conformation; Tryptophan; Tyrosine | 2007 |
Development of a frit-free SPE-based in-column preconcentration system for capillary electrophoresis.
Topics: Animals; Electrophoresis, Capillary; Particle Size; Rats; Solid Phase Microextraction; Spectrophotometry, Ultraviolet; Tyrosine | 2007 |
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice.
Topics: Ambrosia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cyclic AMP; Disease Models, Animal; I-kappa B Proteins; Leukocytes; Lipid Peroxidation; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Phosphorylation; Plethysmography, Whole Body; Pneumonia; Reactive Nitrogen Species; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tyrosine | 2007 |
Deletion of aldose reductase leads to protection against cerebral ischemic injury.
Topics: Aldehyde Reductase; Animals; Apoptosis; Behavior, Animal; Brain; Brain Injuries; Brain Ischemia; Caspase 3; Gene Deletion; Imidazolidines; Infarction, Middle Cerebral Artery; Iron; L-Iditol 2-Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Oxidative Stress; Receptors, Transferrin; Transferrin; Tyrosine | 2007 |
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.
Topics: Animals; Body Temperature; Brain; Brain Injuries; Carotid Arteries; Guanidines; Ischemic Preconditioning; Ligation; Lipopolysaccharides; Male; Membrane Glycoproteins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Superoxides; Tyrosine | 2007 |
Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.
Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Collagen; Drug Combinations; Extracellular Matrix; Female; Interleukin-1alpha; Metalloporphyrins; Oxygen; Peroxynitrous Acid; Proteoglycans; Swine; Tyrosine | 2007 |
Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions.
Topics: Aldehydes; Animals; Arterioles; Brain; Brain Edema; Cerebral Hemorrhage; Cerebrovascular Disorders; Disease Models, Animal; Endothelium, Vascular; Hypertension; Intracranial Arterial Diseases; Male; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroblue Tetrazolium; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine; Up-Regulation | 2007 |
Changes of extracellular matrix of rat cornea after exposure to hypoxia.
Topics: Analysis of Variance; Animals; Collagen; Cornea; Corneal Neovascularization; Extracellular Matrix; Eye Proteins; Free Radicals; Hypoxia; Male; Matrix Metalloproteinases; Oxidative Stress; Rats; Rats, Wistar; Time Factors; Tyrosine | 2008 |
Cyclic compression loaded on cartilage explants enhances the production of reactive oxygen species.
Topics: Animals; Cartilage; Cattle; Immunohistochemistry; Proteoglycans; Reactive Oxygen Species; Stress, Mechanical; Tissue Culture Techniques; Tyrosine | 2007 |
Morning blood pressure surge as a destabilizing factor of atherosclerotic plaque: role of ubiquitin-proteasome activity.
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Artery Diseases; Circadian Rhythm; Humans; Hypertension; In Vitro Techniques; Inflammation; Intracranial Arteriosclerosis; NF-kappa B; Oxidative Stress; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitin; Up-Regulation | 2007 |
Nitrotyrosine and protein carbonyls are equally distributed in HT22 cells after nitrosative stress.
Topics: Carbon; Cell Line, Tumor; Cytosol; Humans; Immunohistochemistry; Microscopy, Fluorescence; Nitric Oxide Donors; Nitrogen; Oxygen; Peroxynitrous Acid; Phenylhydrazines; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2007 |
Glyceryl trinitrate inhibits hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for preeclampsia.
Topics: Aldehydes; Apoptosis; Blotting, Western; Caspase 3; Collagen Type XI; Female; Humans; Hypoxia; Immunohistochemistry; In Situ Nick-End Labeling; Microscopy, Electron, Transmission; Nitroglycerin; Organ Culture Techniques; Pre-Eclampsia; Pregnancy; Reperfusion Injury; Tocolytic Agents; Trophoblasts; Tyrosine | 2007 |
Oxidative and nitrosative stress markers in bus drivers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Air Pollution; Automobile Driving; Biomarkers; Case-Control Studies; Czech Republic; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; F2-Isoprostanes; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Particulate Matter; Tyrosine | 2007 |
Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis.
Topics: Adult; Aspartate Aminotransferases; Biopsy; Dinoprost; Fatty Liver; Female; Glutathione; Humans; Liver; Male; Middle Aged; Mitochondria, Liver; Oxidative Stress; Reference Values; Spleen; Statistics as Topic; Tomography, X-Ray Computed; Tyrosine | 2007 |
Oxidants in the gas phase of cigarette smoke pass through the lung alveolar wall and raise systemic oxidative stress.
Topics: Animals; Deoxyguanosine; Kinetics; Male; Oxidants; Oxidative Stress; Pulmonary Alveoli; Rats; Rats, Wistar; Smoke; Smoking; Specific Pathogen-Free Organisms; Tyrosine | 2007 |
Biochemical characterization of reactive nitrogen species by eosinophil peroxidase in tyrosine nitration.
Topics: Animals; Blotting, Western; Eosinophil Peroxidase; Eosinophils; Gastric Mucosa; Histocytochemistry; Immunohistochemistry; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Peritoneum; Rats; Rats, Wistar; Reactive Nitrogen Species; RNA, Messenger; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2007 |
Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress.
Topics: Adiponectin; Animals; Apoptosis; Cardiotonic Agents; Cells, Cultured; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2007 |
Role of peroxynitrite on cytoskeleton alterations and apoptosis in renal ischemia-reperfusion.
Topics: Animals; Apoptosis; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Caspase 3; Cytoskeleton; In Situ Nick-End Labeling; Kidney Diseases; Kidney Function Tests; Male; Microscopy, Confocal; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2007 |
Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Calcium; Calpain; Cerebral Cortex; Cytoskeleton; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Spectrin; Time Factors; Tissue Distribution; Tyrosine | 2007 |
Prevention of liver cirrhosis in rats by curcumin.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cells, Cultured; Collagen Type I; Curcumin; Cytokines; Gene Expression; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Organ Size; Oxidative Stress; Rats; Rats, Wistar; Spleen; Thioacetamide; Tyrosine | 2007 |
Changes in the expression pattern of the nitrergic system of ovine cerebellum affected by scrapie.
Topics: Animals; Blotting, Western; Cerebellum; Gene Expression; Immunohistochemistry; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Scrapie; Sheep; Tyrosine | 2007 |
Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence.
Topics: Antibodies, Monoclonal; Female; Fluorescence; Humans; Hydrolysis; Immunoassay; Insulin-Like Growth Factor Binding Protein 4; Kinetics; ortho-Aminobenzoates; Peptides; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy-Associated Plasma Protein-A; Prenatal Diagnosis; Protein Subunits; Recombinant Proteins; Sensitivity and Specificity; Tyrosine | 2007 |
Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Dietary Fats; Disease Models, Animal; Enzyme Inhibitors; Farnesyltranstransferase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Oxidative Stress; Phosphorylation; Polyenes; Polyunsaturated Alkamides; Protein Prenylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sinus of Valsalva; Superoxides; Time Factors; Tyrosine | 2007 |
Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ischemia; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Liver Diseases; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Nitrosation; Reactive Oxygen Species; Reperfusion Injury; Thiobarbituric Acid Reactive Substances; Tyrosine | 2007 |
Which comes first: renal inflammation or oxidative stress in spontaneously hypertensive rats?
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Age Factors; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Deoxyguanosine; Disease Models, Animal; Disease Progression; DNA Damage; Glutathione; Hypertension; Kidney Cortex; Male; NADPH Oxidases; Nephritis; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Tyrosine | 2007 |
Reduction of the nitro group during sample preparation may cause underestimation of the nitration level in 3-nitrotyrosine immunoblotting.
Topics: Analytic Sample Preparation Methods; Angiotensin II; Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Immunoblotting; Immunohistochemistry; Liver; Lung; Oxidation-Reduction; Rats; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2007 |
Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis.
Topics: Analysis of Variance; Animals; Brain; Cell Count; Citrulline; Humans; Hydrazines; Mice; Mice, Transgenic; Microdialysis; Mutation; Nerve Tissue Proteins; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2007 |
Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress.
Topics: Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Hyperoxia; Immunohistochemistry; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Oxidative Stress; Respiratory Distress Syndrome; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Scavenger Receptors, Class A; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Heart; Immunohistochemistry; Male; Metallothionein; Mice; Mice, Knockout; Myocardium; Peroxynitrous Acid; Superoxides; Troponin T; Tyrosine; Zinc | 2007 |
Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction.
Topics: Acetylcholine; Aging; Animals; Enzyme Inhibitors; Heart; Immunohistochemistry; Indoles; Models, Animal; Myocardium; Phenylephrine; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Tyrosine | 2007 |
Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats.
Topics: Aldehydes; Animals; Animals, Newborn; Biogenic Polyamines; Brain Chemistry; Central Nervous System Depressants; Eflornithine; Enzyme Inhibitors; Ethanol; Hippocampus; Male; Nerve Tissue Proteins; Ornithine Decarboxylase Inhibitors; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Topics: Adolescent; Adult; Aged; Animals; Brain; Brain Injuries; Chemotaxis, Leukocyte; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nerve Degeneration; Nitrates; Nitric Oxide Synthase Type I; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amnesia; Biomarkers; Brain; Cognition Disorders; Disease Progression; Early Diagnosis; Female; Hippocampus; Humans; Immunohistochemistry; Male; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Parietal Lobe; Predictive Value of Tests; Prognosis; Tyrosine; Up-Regulation | 2007 |
Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death.
Topics: Animals; Blood Pressure; Brain Death; Cyclic GMP-Dependent Protein Kinases; Diamines; Disease Models, Animal; Ditiocarb; Enzyme Induction; Heart Rate; Male; Medulla Oblongata; Mevinphos; Muscarinic Antagonists; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Reproducibility of Results; Thiocarbamates; Time Factors; Transcription, Genetic; Tropicamide; Tyrosine | 2007 |
Reactive oxygen species plasmatic levels in ischemic stroke.
Topics: Aged; Atherosclerosis; Brain Ischemia; Case-Control Studies; Female; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Thrombosis; Tyrosine | 2007 |
Role of nitric oxide as mediator of nerve injury in inflammatory neuropathies.
Topics: Animals; Cell Survival; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cyclic N-Oxides; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Free Radical Scavengers; Ganglia, Spinal; Humans; Imidazoles; Neurites; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Polyradiculoneuropathy; Rats; Schwann Cells; Sural Nerve; Tyrosine | 2007 |
Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide.
Topics: Animals; Behavior, Animal; Blood Gas Analysis; Body Fluids; Bronchoalveolar Lavage Fluid; Hyperoxia; L-Lactate Dehydrogenase; Lung; Lung Diseases; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxygen; Pneumonia; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Survival Analysis; Tyrosine; Vagotomy | 2007 |
Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Fibrosis; Gene Expression Regulation; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hyperlipoproteinemia Type II; Immediate-Early Proteins; Inflammation; Intercellular Signaling Peptides and Proteins; Isoenzymes; Macrophages; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Oxidation-Reduction; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Sinus of Valsalva; Streptozocin; Superoxide Dismutase; Tyrosine; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A | 2007 |
Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis.
Topics: Astrocytes; Cell Death; Cells, Cultured; Demyelinating Diseases; Humans; Macrophages; Multiple Sclerosis; Myelin Sheath; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oligodendroglia; Peroxynitrous Acid; Tyrosine | 2007 |
Isohumulones derived from hops ameliorate renal injury via an anti-oxidative effect in Dahl salt-sensitive rats.
Topics: Animals; Antioxidants; Blood Pressure; Blotting, Western; Cyclopentanes; Humulus; Hypertension; Kidney Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Proteinuria; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Sodium Chloride; Tyrosine | 2007 |
Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products.
Topics: Animals; Cells, Cultured; Glycation End Products, Advanced; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Transcription, Genetic; Tyrosine; Vascular Diseases | 2007 |
Efficiency of lornoxicam in lung and trachea injury caused by peroxynitrite.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Female; Lung; Male; Malondialdehyde; Peroxidase; Peroxynitrous Acid; Piroxicam; Rats; Respiratory Distress Syndrome; Trachea; Tracheal Diseases; Tyrosine | 2008 |
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.
Topics: Adolescent; Adult; Aged; Aging; Brachial Artery; Catalase; Endothelial Cells; Fluorescent Antibody Technique; Humans; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Reference Values; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Up-Regulation; Vasodilation; Veins; Xanthine Oxidase | 2007 |
A method for selective enrichment and analysis of nitrotyrosine-containing peptides in complex proteome samples.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Cattle; Chromatography, Liquid; Humans; Mass Spectrometry; Mice; Molecular Sequence Data; Peptides; Proteins; Proteome; Proteomics; Tyrosine | 2007 |
Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock.
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Ceftazidime; Disease Models, Animal; Female; Heart Rate; Hemodynamics; Lung; Nitrates; Nitrites; Oxygen Consumption; Random Allocation; Sheep; Shock, Septic; Smoke Inhalation Injury; Tyrosine | 2007 |
Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers.
Topics: Aldehydes; Animals; Cell Respiration; Cerebral Cortex; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Transport Complex I; Free Radical Scavengers; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitochondria; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Oxygen Consumption; Penicillamine; Peroxynitrous Acid; Protein Carbonylation; Spin Labels; Tyrosine | 2007 |
Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.
Topics: Animals; Coronary Vessels; Cytochromes c; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Infarction; Myocardium; NADH Dehydrogenase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Random Allocation; Reactive Oxygen Species; Regional Blood Flow; Tyrosine | 2007 |
A peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-alpha is neither necessary nor sufficient.
Topics: Animals; Blood-Brain Barrier; CD4-Positive T-Lymphocytes; Cell Membrane Permeability; Cell Movement; Cerebellum; Encephalomyelitis, Autoimmune, Experimental; Female; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxynitrous Acid; Rabies virus; Signal Transduction; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha; Tyrosine; Viral Load | 2007 |
Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Brain Ischemia; Caspase 3; Cerebral Infarction; Chemotaxis, Leukocyte; Cilostazol; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Peroxidase; Poly(ADP-ribose) Polymerases; Probucol; Rats; Rats, Sprague-Dawley; Superoxides; Telencephalon; Tetrazoles; Treatment Outcome; Tyrosine | 2007 |
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; Cytokines; Disease Models, Animal; Endotoxemia; Hyperammonemia; Ligation; Lipopolysaccharides; Liver Cirrhosis, Experimental; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis.
Topics: Animals; Apoptosis; bcl-X Protein; Caspases; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension, Renovascular; Kidney; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice.
Topics: Acetone; Animals; Apoptosis; Caspase 3; Catalysis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; DNA Adducts; DNA Fragmentation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Lipid Peroxidation; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Nitric Oxide Synthase Type II; Obesity; Proteins; Pyrazoles; RNA, Messenger; Solvents; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Age modulates the nitric oxide system response in the ischemic cerebellum.
Topics: Aging; Animals; Astrocytes; Brain Ischemia; Cerebellar Diseases; Cerebellum; Down-Regulation; Glial Fibrillary Acidic Protein; Gliosis; Isoenzymes; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Reperfusion Injury; Time Factors; Tyrosine; Up-Regulation | 2007 |
Nitrotyrosylation of Ca2+ channels prevents c-Src kinase regulation of colonic smooth muscle contractility in experimental colitis.
Topics: Animals; Calcium; Calcium Channels; Colitis; Colon; CSK Tyrosine-Protein Kinase; Disease Models, Animal; Electrophysiology; Humans; Inflammation; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Nitric Acid; Protein-Tyrosine Kinases; src-Family Kinases; Tyrosine | 2007 |
L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep.
Topics: Airway Obstruction; Animals; Arginine; Blood Pressure; Burns; Female; Hematocrit; Lung; Lung Injury; Nitrates; Nitrites; Random Allocation; Sheep; Smoke Inhalation Injury; Survival Analysis; Tyrosine; Urination | 2007 |
Oxidative stress, nitric oxide, and the mechanisms of cell death in Lurcher Purkinje cells.
Topics: Animals; Calbindins; Cell Death; Cerebellum; Mice; Mice, Neurologic Mutants; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Purkinje Cells; S100 Calcium Binding Protein G; Superoxide Dismutase; Tyrosine | 2007 |
o-Nitrotyrosine and p-iodophenylalanine as spectroscopic probes for structural characterization of SH3 complexes.
Topics: Circular Dichroism; Fluorescence Resonance Energy Transfer; Peptides; Phenylalanine; Protein Binding; Proteins; src Homology Domains; Tryptophan; Tyrosine | 2007 |
The relationship between taurine and 3-nitrotyrosine level of hepatocytes in experimental endotoxemia.
Topics: Animals; Endotoxemia; Guinea Pigs; Hepatocytes; Lipopolysaccharides; Male; Peroxynitrous Acid; Taurine; Tyrosine | 2007 |
Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.
Topics: Animals; Argininosuccinate Synthase; Brain; Cathepsin D; Cationic Amino Acid Transporter 2; Cell Shape; Cells, Cultured; Enzyme Activation; Lysosomes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pepstatins; Protease Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2007 |
Effects of post-translational modifications on prion protein aggregation and the propagation of scrapie-like characteristics in vitro.
Topics: Amyloid; Animals; Brain; Endopeptidase K; Kinetics; Mice; Nitrogen; Oxidative Stress; Prions; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; Scrapie; Sheep; Tyrosine | 2007 |
Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection.
Topics: Acute Disease; Animals; Bilirubin; Biomarkers; Blotting, Western; Dipyrone; Disease Models, Animal; Disease Progression; Free Radical Scavengers; Graft Rejection; Heart Transplantation; Heme Oxygenase-1; Immunohistochemistry; Myocardium; Nitric Oxide; Oxidation-Reduction; Prognosis; Rats; Transplantation, Homologous; Tyrosine | 2007 |
Temporal characterization of mitochondrial bioenergetics after spinal cord injury.
Topics: Aldehydes; Animals; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Free Radicals; Lipid Peroxidation; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spinal Cord; Spinal Cord Injuries; Time Factors; Tyrosine | 2007 |
Insulin-induced impairment via peroxynitrite production of endothelium-dependent relaxation and sarco/endoplasmic reticulum Ca(2+)-ATPase function in aortas from diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Immunohistochemistry; Insulin; Male; Muscle, Smooth, Vascular; Nitrites; Nitroblue Tetrazolium; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2007 |
Effects of selective iNOS inhibition on systemic hemodynamics and mortality rate on endotoxic shock in streptozotocin-induced diabetic rats.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hemodynamics; Lipopolysaccharides; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Tyrosine | 2007 |
Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Brain Injuries; Cyclooxygenase 2; Encephalitis; Fenofibrate; Glutathione; Male; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Oxidative Stress; PPAR alpha; Rats; Rats, Sprague-Dawley; Recovery of Function; Treatment Outcome; Tyrosine | 2007 |
Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.
Topics: Animals; Aorta; Apolipoprotein A-I; Atherosclerosis; Autoantibodies; Blood Coagulation; Blood Proteins; Cholesterol, HDL; Disease Models, Animal; Female; Fibrin; Fibrinogen; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Nitrogen; Oxidants; Proteomics; Tyrosine | 2007 |
Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger.
Topics: Antioxidants; Cells, Cultured; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2007 |
Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veins.
Topics: Animals; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fetus; Hypoxia; Isoenzymes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitrates; Nitrites; Peroxynitrous Acid; Pulmonary Veins; Reactive Nitrogen Species; Reactive Oxygen Species; Sheep; Time Factors; Tyrosine; Vasodilation | 2007 |
Inhibition of inducible nitric oxide synthase in vitro and in vivo by a water-soluble extract of Wendita calysina leaves.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Exudates and Transudates; Geraniaceae; In Vitro Techniques; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Male; Mice; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Plant Leaves; Pleurisy; Poly Adenosine Diphosphate Ribose; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
Homocysteine induces endothelial dysfunction via inhibition of arginine transport.
Topics: Acetylcholine; Animals; Arginine; Biological Transport; Cationic Amino Acid Transporter 1; Cattle; Cells, Cultured; Endothelial Cells; Homocysteine; Male; Membrane Potentials; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine; Vasodilation | 2007 |
FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms.
Topics: Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glutathione Peroxidase; Immunohistochemistry; Male; Nerve Regeneration; Nitric Oxide Synthase; Penile Erection; Penis; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tacrolimus; Tyrosine; Vasodilator Agents | 2007 |
Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.
Topics: Animals; Arrhythmias, Cardiac; Calcium; Coronary Circulation; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Heterocyclic Compounds, 3-Ring; Immunohistochemistry; Isoenzymes; Mice; Mice, Transgenic; Mitochondria, Heart; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Fluorescence; Time Factors; Tyrosine; Ventricular Function, Left; Ventricular Pressure | 2007 |
17Beta-estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biomarkers; Cell Count; Estradiol; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Substantia Nigra; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine; Up-Regulation | 2007 |
Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries.
Topics: Animals; Antioxidants; Blood Glucose; Capillaries; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Immunologic Techniques; Insulin; Male; Osmolar Concentration; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Retina; Retinal Vessels; Staining and Labeling; Superoxide Dismutase; Tyrosine | 2007 |
A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.
Topics: Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fluorescent Antibody Technique; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Nerve Fibers; Neurons; Pain Threshold; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Reaction Time; Sciatic Nerve; Spinal Nerve Roots; Streptozocin; Tyrosine | 2007 |
Oxidative stress is related to the formation of Antoni B patterns and eosinophilic hyaline droplets in schwannomas.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Apolipoproteins D; Autophagy; Caspase 3; Deoxyguanosine; Female; Humans; Hyalin; Immunohistochemistry; Inclusion Bodies; Male; Middle Aged; Neurilemmoma; Nitric Oxide Synthase Type II; Oxidative Stress; Tyrosine | 2007 |
Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Asphyxia Neonatorum; Autopsy; Caspase 3; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Inflammation; Male; Nitric Oxide; Spinal Cord; Tyrosine | 2008 |
Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Fatty Liver; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Microscopy, Electron; Mitochondria, Liver; PPAR gamma; Rosiglitazone; Thiazolidinediones; Tyrosine | 2007 |
Abnormal processing of tau in the brain of aged TgCRND8 mice.
Topics: Aging; Animals; Brain; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Inclusion Bodies; Male; MAP Kinase Kinase 4; Mice; Mice, Transgenic; Phosphorylation; Plaque, Amyloid; tau Proteins; Tyrosine | 2007 |
A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis.
Topics: Animals; Body Weight; Cholesterol; Colonic Neoplasms; DNA, Single-Stranded; Immunohistochemistry; Inflammation; Male; Mice; Molecular Structure; Organ Size; Proliferating Cell Nuclear Antigen; Quinolines; Time Factors; Triglycerides; Tyrosine | 2007 |
Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice.
Topics: Animals; Apolipoprotein B-100; Cholesterol; Cholesterol, Dietary; Female; Heart Diseases; Humans; Hypercholesterolemia; Immunohistochemistry; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Myocardium; NADPH Oxidases; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Regional Blood Flow; Superoxides; Triglycerides; Tyrosine | 2007 |
Apoptosis bcl-2 and nitrotyrosine expression in an angioplasty-restenosis rabbit: an experimental model.
Topics: Angioplasty, Balloon; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Movement; Cell Proliferation; Iliac Artery; Immunoenzyme Techniques; In Situ Nick-End Labeling; Male; Membrane Proteins; Muscle, Smooth, Vascular; Proto-Oncogene Proteins; Rabbits; Recurrence; Statistics, Nonparametric; Tyrosine | 2007 |
Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Blotting, Western; Chlorogenic Acid; Dermatitis, Contact; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Glucosides; Hydroquinones; Interleukin-1beta; Interleukin-4; Mice; Neutrophils; Nitric Oxide Synthase Type II; Random Allocation; Skin; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury.
Topics: Animals; Catalysis; Disease Models, Animal; DNA; I-kappa B Proteins; Interleukin-1beta; Interleukin-2; Lipid Peroxidation; Male; Metalloporphyrins; Mice; Mitochondria; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; RNA; Spinal Cord Injuries; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Phenylephrine; Potassium Chloride; Species Specificity; Superoxide Dismutase; Superoxides; Tyrosine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Role of endogenous glutathione in the secondary damage in experimental spinal cord injury in mice.
Topics: Animals; Antimetabolites; Apoptosis; bcl-2-Associated X Protein; Buthionine Sulfoximine; DNA; Glutathione; Immunohistochemistry; In Situ Nick-End Labeling; Kinetics; Lipid Peroxidation; Male; Malondialdehyde; Mice; Neutrophil Infiltration; Peroxidase; Poly Adenosine Diphosphate Ribose; RNA; Spinal Cord Compression; Spinal Cord Injuries; Tyrosine | 2007 |
Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats.
Topics: Adenylyl Cyclases; Animals; Antioxidants; Azoles; Colforsin; Coronary Vessels; Cyclic AMP; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Activators; Isoindoles; Kv1.2 Potassium Channel; Kv1.5 Potassium Channel; Male; Membrane Potentials; Muscle, Smooth, Vascular; Organoselenium Compounds; Oxidative Stress; Peroxynitrous Acid; Potassium Channel Blockers; Protein Subunits; Rats; Rats, Sprague-Dawley; Research Design; Triterpenes; Tyrosine; Vasodilation | 2007 |
Pioglitazone ameliorates endothelial dysfunction in obese rats with nephropathy.
Topics: Animals; Endothelium, Vascular; Kidney Diseases; Kidney Glomerulus; Male; Metabolic Syndrome; NADPH Oxidases; Obesity; Pioglitazone; Polymerase Chain Reaction; Rats; Rats, Zucker; RNA, Messenger; Thiazolidinediones; Tyrosine; Vasodilation | 2007 |
Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infants.
Topics: Free Radicals; Gastrointestinal Tract; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Nitrophenols; Oxidative Stress; Oxygen; Phenylacetates; Tyrosine | 2008 |
Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Blood Urea Nitrogen; Creatinine; Cysteine; Cytoprotection; Garlic; Hypertension; Kidney; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type II; Plant Extracts; Poly Adenosine Diphosphate Ribose; Proteinuria; Rats; Rats, Wistar; Superoxide Dismutase; Systole; Tyrosine | 2007 |
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Topics: Animals; Animals, Genetically Modified; Aorta; Apolipoprotein A-I; Betaine; Cholesterol; Disease Models, Animal; Fatty Liver; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Lipotropic Agents; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Time; Triglycerides; Tyrosine | 2007 |
Effect of chronic nicotine administration on the rat lung and liver: beneficial role of melatonin.
Topics: Animals; Drug Antagonism; Free Radical Scavengers; Ganglionic Stimulants; Glutathione; Lipid Peroxidation; Liver; Lung; Male; Melatonin; Nicotine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2007 |
Nitrotyrosine as an oxidative stress marker: evidence for involvement in neurologic outcome in human traumatic brain injury.
Topics: Adolescent; Adult; Biomarkers; Brain Injuries; Case-Control Studies; Cohort Studies; Craniotomy; Enzyme-Linked Immunosorbent Assay; Female; Glasgow Coma Scale; Humans; Immunohistochemistry; Injury Severity Score; Intracranial Pressure; Male; Middle Aged; Monitoring, Physiologic; Oxidative Stress; Prognosis; Reference Values; Sensitivity and Specificity; Tyrosine | 2007 |
Effects of resveratrol on glycerol-induced renal injury.
Topics: Animals; Antioxidants; Blotting, Western; Glycerol; Heme Oxygenase-1; Immunohistochemistry; Kidney Cortex; Kidney Diseases; Kidney Function Tests; Lipid Peroxidation; Lymphocytes; Macrophages; Male; Malondialdehyde; NF-kappa B; Rats; Rats, Wistar; Resveratrol; Stilbenes; Tyrosine | 2007 |
Lead exposure effect on angiotensin II renal vasoconstriction.
Topics: Administration, Oral; Angiotensin II; Animals; Blotting, Western; Dose-Response Relationship, Drug; Endothelial Cells; Immunohistochemistry; In Vitro Techniques; Injections; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Papaverine; Perfusion; Rats; Rats, Wistar; Renal Artery; Superoxides; Tyrosine; Vasoconstriction | 2007 |
Effect of 17beta-estradiol on signal transduction pathways and secondary damage in experimental spinal cord trauma.
Topics: Animals; Apoptosis; Base Sequence; bcl-2-Associated X Protein; Chemokines; Cyclooxygenase 2; Cytokines; DNA Primers; Estradiol; Male; Mice; Motor Activity; Neutrophils; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spinal Cord Injuries; Tyrosine | 2008 |
Novel inhibitors of glycation and AGE formation.
Topics: Animals; Ascorbic Acid; Body Weight; Butyrates; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dyslipidemias; Glycation End Products, Advanced; Glycosylation; Hydroxyl Radical; Hypoglycemic Agents; Kidney; Lipid Metabolism; Lipoproteins, LDL; Male; Molecular Structure; Oxidation-Reduction; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Triglycerides; Tyrosine | 2007 |
Identification of a denitrase activity against calmodulin in activated macrophages using high-field liquid chromatography--FTICR mass spectrometry.
Topics: Animals; Calmodulin; Chickens; Chromatography, Liquid; Lysine; Macrophage Activation; Macrophages; Mass Spectrometry; Mice; Oxidation-Reduction; Protein Isoforms; Tyrosine | 2007 |
Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function.
Topics: Animals; Body Weight; Disease Models, Animal; Glycation End Products, Advanced; Glyoxal; Kidney Failure, Chronic; Ligation; Male; Nephrectomy; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Wistar; Tyrosine | 2007 |
Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biopterins; Dietary Fats; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Nitro Compounds; Organ Specificity; Oxidation-Reduction; Proteins; Tissue Distribution; Tyrosine | 2007 |
Mouse models of diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; DNA Fragmentation; Hyperalgesia; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NOD; Nerve Fibers; Neural Conduction; Pain Measurement; Reaction Time; Streptozocin; Tyrosine; Ubiquitin Thiolesterase | 2007 |
Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake.
Topics: Adipokines; Analysis of Variance; Biomarkers; Carrier Proteins; Case-Control Studies; Fatty Liver; Feeding Behavior; Female; Humans; Insulin Resistance; Liver; Male; Metabolic Syndrome; Middle Aged; Oxidative Stress; Polymorphism, Genetic; Risk Factors; Severity of Illness Index; Tyrosine; Vitamin A | 2007 |
Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation.
Topics: Antioxidants; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Hyaluronic Acid; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Stromal Cells; Tyrosine | 2007 |
Gender difference as regards myocardial protein oxidation in aged rats: male rats have increased oxidative protein damage.
Topics: Aging; Animals; Female; Glutathione; Iron; Lipid Peroxidation; Longevity; Male; Malondialdehyde; Myocardium; Oxidation-Reduction; Oxidative Stress; Peroxides; Protein Carbonylation; Proteins; Rats; Rats, Sprague-Dawley; Sex Factors; Sulfhydryl Compounds; Tyrosine | 2007 |
Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Barrett Esophagus; Chronic Disease; Esophageal Neoplasms; Female; Genes, p53; Humans; Inflammation Mediators; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Point Mutation; Tumor Suppressor Protein p53; Tyrosine | 2008 |
Bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Dopamine; Electron Transport Complex I; Energy Metabolism; Glutathione; Hydrogen Peroxide; Mice; Neurons; Oxidation-Reduction; Prosencephalon; Rotenone; Tyrosine | 2007 |
Desmin is oxidized and nitrated in affected muscles in myotilinopathies and desminopathies.
Topics: Aged; Aged, 80 and over; Connectin; Cytoskeletal Proteins; Database Management Systems; Desmin; Electrophoresis, Gel, Two-Dimensional; Female; Glycation End Products, Advanced; Humans; Male; Mass Spectrometry; Microfilament Proteins; Middle Aged; Muscle Proteins; Muscular Diseases; Tyrosine | 2007 |
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats.
Topics: Animals; Behavior, Animal; Cerebral Infarction; Humans; Intracellular Signaling Peptides and Proteins; Magnetic Resonance Imaging; Nerve Degeneration; Oncogene Proteins; Protein Deglycase DJ-1; Rats; Reactive Oxygen Species; Reperfusion Injury; Tyrosine | 2008 |
Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis.
Topics: Animals; Disease Models, Animal; Female; Hematocrit; Hemodynamics; Lung; Methicillin; Methicillin Resistance; Pneumonia; Sepsis; Sheep; Smoke Inhalation Injury; Staphylococcus aureus; Time Factors; Tyrosine | 2008 |
Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.
Topics: Animals; Arginase; Asthma; Collagen; Cytokines; Gene Expression Regulation, Enzymologic; Goblet Cells; Immunohistochemistry; Isoenzymes; Male; Mice; Nitrates; Nitric Oxide Synthase Type II; Nitrites; RNA, Messenger; Tyrosine; Up-Regulation | 2007 |
Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjögren's syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Aldehydes; Antioxidants; Apoptosis; Biomarkers; Cysteine Proteinase Inhibitors; Deoxyguanosine; Female; Humans; Hydrogen Peroxide; Interferon-gamma; Interleukin-6; Middle Aged; Oxidants; Oxidative Stress; Saliva; Salivary Glands; Sjogren's Syndrome; Thioredoxins; Tyrosine | 2007 |
Nitration of soluble proteins in organotypic culture models of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Neurochemistry; Neurotoxins; Nitric Oxide Donors; Nitric Oxide Synthase; Nitro Compounds; Organ Culture Techniques; Oxidative Stress; Parkinson Disease; Proteins; Pterins; Reactive Nitrogen Species; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase; Uncoupling Agents | 2008 |
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite.
Topics: Aconitate Hydratase; Animals; Catalase; Cattle; Cells, Cultured; Citric Acid Cycle; Endothelial Cells; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Glucose; Hydrogen Peroxide; Hyperglycemia; Immunohistochemistry; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Mitochondria; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Phenanthridines; Superoxides; Time Factors; Triazoles; Tyrosine | 2007 |
Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Heme; Humans; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Peroxynitrous Acid; tert-Butylhydroperoxide; Tyrosine | 2007 |
Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Female; Genes, Reporter; Humans; I-kappa B Proteins; Kinetics; Luciferases; Models, Molecular; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type I; Nitrogen; Nuclear Magnetic Resonance, Biomolecular; Oxidants; Peroxynitrous Acid; Protein Processing, Post-Translational; Quantum Theory; Radiation, Ionizing; RNA, Small Interfering; Transfection; Tyrosine | 2007 |
Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.
Topics: Animals; Aorta; Arterioles; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; Mesenteric Arteries; Metalloporphyrins; Neural Conduction; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Wistar; Regional Blood Flow; Sciatic Nerve; Superoxides; Tyrosine; Vasodilator Agents | 2007 |
The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells.
Topics: Animals; Atherosclerosis; Caveolae; Caveolin 1; Cell Line; Cells, Cultured; Endothelial Cells; Environmental Pollutants; Enzyme Activation; Humans; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polychlorinated Biphenyls; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Swine; Time Factors; Tyrosine | 2007 |
Signal transduction and oxidative processes in sinonasal polyposis.
Topics: Adult; Enzyme Inhibitors; Female; Humans; Male; Nasal Polyps; Nitric Oxide; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Oxidation-Reduction; Oxygen Consumption; Polymorphism, Single Nucleotide; Signal Transduction; STAT1 Transcription Factor; Substrate Specificity; Superoxide Dismutase; Tyrosine | 2007 |
Incorporation of the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester to red blood cell membranes to study peroxynitrite-dependent reactions.
Topics: Carbon Dioxide; Dimerization; Erythrocyte Membrane; Free Radicals; Humans; Hydrophobic and Hydrophilic Interactions; Nitrogen; Oxidation-Reduction; Oxyhemoglobins; Peroxynitrous Acid; Tyrosine | 2007 |
Combination of dexamethasone and etanercept reduces secondary damage in experimental spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Etanercept; Immunoglobulin G; In Situ Nick-End Labeling; Interleukin-1beta; Laminectomy; Male; Mice; Neutrophils; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.
Topics: Cell Line; Cytochrome P-450 CYP4A; Cytokines; Dinoprost; Dinoprostone; Endothelial Cells; Humans; Hydroxyeicosatetraenoic Acids; I-kappa B Kinase; Intercellular Adhesion Molecule-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Tyrosine | 2008 |
Hypertension increases pro-oxidant generation and decreases antioxidant defense in the kidney in early diabetes.
Topics: Animals; Antioxidants; Blood Pressure; Diabetic Nephropathies; Female; Glutathione; Hypertension, Renal; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Oxidants; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Tyrosine | 2008 |
Quantitative evaluation of time-resolved fluorescence microscopy using a new europium label: application to immunofluorescence imaging of nitrotyrosine in kidneys.
Topics: Europium; Fluorescent Antibody Technique; In Vitro Techniques; Kidney; Microscopy, Fluorescence; Tyrosine | 2008 |
Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Cells, Cultured; Chloroform; Cyclosporine; Female; Glutathione; Hepatocytes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2007 |
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.
Topics: Analgesics, Opioid; Animals; Cytokines; DNA Damage; Drug Tolerance; Enzyme Inhibitors; Free Radical Scavengers; Humans; Male; Metalloporphyrins; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Threshold; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Porphyrins; Rats; Spinal Cord; Superoxide Dismutase; Tyrosine | 2007 |
Investigation of zinc and copper levels in methimazole-induced hypothyroidism: relation with the oxidant-antioxidant status.
Topics: Animals; Antioxidants; Copper; Female; Glutathione; Hypothyroidism; Methimazole; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine; Zinc | 2007 |
Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins.
Topics: Age Factors; Aging; Animals; Apoferritins; Carrier Proteins; Cation Transport Proteins; Iron; Iron Regulatory Protein 1; Lipid Peroxides; Male; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Inbred F344; Receptors, Transferrin; Tyrosine; Up-Regulation | 2008 |
A DFT study of the nitric oxide and tyrosyl radical interaction: a proposed radical mechanism.
Topics: Catalysis; Chemistry, Physical; Free Radicals; Hydrogen Bonding; Imines; Ions; Models, Chemical; Models, Theoretical; Molecular Conformation; Nitrates; Nitric Oxide; Tyrosine; Water | 2007 |
Fenofibrate treatment of diabetic rats reduces nitrosative stress, renal cyclooxygenase-2 expression, and enhanced renal prostaglandin release.
Topics: Animals; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Fenofibrate; Gene Expression Regulation, Enzymologic; Kidney; Male; Prostaglandins; Rats; Rats, Wistar; Tyrosine | 2008 |
Protection against lipopolysaccharide-induced myocardial dysfunction in mice by cardiac-specific expression of soluble Fas.
Topics: Animals; Caspase 3; Caspase 7; Cell Death; Cytokines; Echocardiography; Enzyme Activation; fas Receptor; Gene Expression Regulation; Heart; Lipopolysaccharides; Male; Mice; Myocardium; NF-kappa B; Nitric Oxide Synthase Type II; Organ Specificity; Sepsis; Solubility; Toll-Like Receptor 4; Tyrosine | 2008 |
Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.
Topics: Acute Disease; Aldehydes; Animals; Biomarkers; Brain Injuries; Cyclosporine; Dose-Response Relationship, Drug; Immunoblotting; Lipid Peroxidation; Male; Mice; Mitochondrial Diseases; Oxidative Stress; Oxygen Consumption; Structure-Activity Relationship; Tyrosine | 2008 |
LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice.
Topics: Animals; Creatine Kinase, MB Form; Gene Deletion; Hemodynamics; Malondialdehyde; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-akt; Scavenger Receptors, Class E; Signal Transduction; Superoxide Dismutase; Tyrosine | 2008 |
Simultaneous determination of 3-nitrotyrosine, tyrosine, hydroxyproline and proline in exhaled breath condensate by hydrophilic interaction liquid chromatography/electrospray ionization tandem mass spectrometry.
Topics: Adult; Breath Tests; Chromatography, Liquid; Female; Humans; Hydroxyproline; Male; Middle Aged; Proline; Pulmonary Fibrosis; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2007 |
Mechanisms of protection against pulmonary hyperbaric O(2) toxicity by intermittent air breaks.
Topics: Air; Animals; Blotting, Western; Gene Expression; Heme Oxygenase-1; Hyperbaric Oxygenation; Kinetics; Lung; Male; Nitric Oxide Synthase Type II; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tyrosine | 2008 |
Nitric oxide bioavailability and not production is first altered during the onset of insulin resistance in sucrose-fed rats.
Topics: Animals; Aorta; Biomarkers; Cyclic GMP; Cysteine; Diet; Diet Therapy; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Insulin Resistance; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Sucrose; Sweetening Agents; Tyrosine | 2007 |
X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants.
Topics: Aldehydes; Animals; Antioxidants; Brain; Brain Ischemia; Cytochromes c; Female; Gene Expression; Hypoxia, Brain; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Oxidative Stress; Tyrosine; Up-Regulation; X-Linked Inhibitor of Apoptosis Protein | 2007 |
Selective iNOS inhibition reduces renal damage induced by cisplatin.
Topics: Aldehydes; Amidines; Animals; Antineoplastic Agents; Benzylamines; Cisplatin; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kidney; Kidney Diseases; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2008 |
Macrophage migration inhibitory factor (MIF) is necessary for progression of autoimmune diabetes mellitus.
Topics: Adoptive Transfer; Animals; Antibodies, Monoclonal; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cyclophosphamide; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Progression; Female; Gene Expression Regulation; Intramolecular Oxidoreductases; Islets of Langerhans; Leukocytes, Mononuclear; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred NOD; Nitric Oxide; Nitric Oxide Synthase Type II; RNA, Messenger; Spleen; Streptozocin; Tyrosine | 2008 |
Proteomic identification of tyrosine nitration targets in kidney of spontaneously hypertensive rats.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Cytosol; Electrophoresis, Gel, Two-Dimensional; Kidney; Kidney Medulla; Molecular Sequence Data; Nitrogen; Protein Carbonylation; Proteins; Proteomics; Rats; Rats, Inbred SHR; Rats, Wistar; Tyrosine | 2007 |
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
Topics: Actins; Animals; Blood Pressure; Cell Movement; Collagen Type IV; Creatinine; Disease Models, Animal; Hypertension; Hypertrophy; Inflammation; Kidney; Kidney Failure, Chronic; Leukocytes; Male; Malondialdehyde; Melatonin; Nephrectomy; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Transforming Growth Factor beta; Tyrosine | 2008 |
Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity.
Topics: Adult; AIDS Dementia Complex; Biomarkers; Brain; Cohort Studies; Disease Progression; Down-Regulation; Enzyme Activation; Female; Humans; Intramolecular Oxidoreductases; Lipocalins; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrosation; Oxidative Stress; Predictive Value of Tests; Substance Abuse, Intravenous; Tyrosine; Up-Regulation | 2008 |
Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antipsychotic Agents; Anxiety; Brain; Dibenzothiazepines; Disease Models, Animal; Female; Male; Memory Disorders; Mice; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Protease Nexins; Proto-Oncogene Proteins c-bcl-2; Quetiapine Fumarate; Receptors, Cell Surface; Tyrosine | 2009 |
Modulation of proteasome activity by vitamin E in THP-1 monocytes.
Topics: Cell Line; Cyclin-Dependent Kinase Inhibitor p27; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Monocytes; Oxidative Stress; Protease Inhibitors; Proteasome Endopeptidase Complex; Ritonavir; Tocopherols; Tocotrienols; Tumor Suppressor Protein p53; Tyrosine; Vitamin E | 2007 |
How DMSO, a widely used solvent, affects spinal cord injury.
Topics: Animals; Aorta, Abdominal; Dimethyl Sulfoxide; Disease Models, Animal; Free Radical Scavengers; Ligation; Malondialdehyde; Neuroprotective Agents; Nitrates; Nitrites; Peroxidase; Rabbits; Reperfusion Injury; Solvents; Spinal Cord; Spinal Cord Ischemia; Time Factors; Tyrosine | 2008 |
The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans.
Topics: Adult; Case-Control Studies; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Isoprostanes; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Oxidative Stress; Peroxidase; Superoxide Dismutase; Tyrosine | 2008 |
Anti-tumor effects of liposome-encapsulated titanium dioxide in nude mice.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Liposomes; Male; Mice; Mice, Nude; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Titanium; Tyrosine; Urinary Bladder Neoplasms | 2007 |
Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Esters; Fatty Acids, Nonesterified; Glucose Intolerance; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Molecular Weight; Niacinamide; Oxidative Stress; Pancreas; Piperidines; Streptozocin; Time Factors; Tyrosine | 2007 |
Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation.
Topics: Animals; Blood Vessels; Boronic Acids; Bortezomib; Drug Evaluation, Preclinical; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Laser-Doppler Flowmetry; Male; Mice; Microscopy, Video; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Protease Inhibitors; Proteasome Inhibitors; Proteins; Pyrazines; Random Allocation; Reperfusion Injury; Surgical Flaps; Tyrosine | 2007 |
Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chlorogenic Acid; Disease Models, Animal; Endothelium, Vascular; Heart Rate; Hydrogen Peroxide; Hydroquinones; Hypertension; Immunohistochemistry; Male; Nitric Oxide; Nitroprusside; Quinic Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2008 |
[Effects of propofol on the changes in cytoskeleton and cellular permeability of human umbilical vascular endothelial cells monolayer induced by lipopolysaccharide].
Topics: Actins; Cell Membrane Permeability; Cells, Cultured; Cytoskeleton; Endothelial Cells; Humans; Lipopolysaccharides; Propofol; Tyrosine; Umbilical Veins | 2007 |
Oxidative stress and the deleterious consequences to the rat cochlea after prenatal chronic mild exposure to carbon monoxide in air.
Topics: Animals; Animals, Newborn; Antimetabolites; Carbon Monoxide; Cochlea; Female; Gene Expression Regulation, Developmental; Heme Oxygenase-1; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxide Dismutase-1; Synapsins; Tyrosine | 2008 |
A profound decrease in maternal arginine uptake provokes endothelial nitration in the pregnant rat.
Topics: Animals; Aorta, Thoracic; Arginine; Blotting, Northern; Blotting, Western; Cationic Amino Acid Transporter 1; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Immunohistochemistry; Immunoprecipitation; Leukocytes; Nitrates; Peroxynitrous Acid; Placenta; Pregnancy; Pregnancy, Animal; Protein Kinase C; Rats; RNA, Messenger; Tyrosine; Vitamin E | 2008 |
The effect of partial bladder outlet obstruction on carbonyl and nitrotyrosine distribution in rabbit bladder.
Topics: Animals; Carbachol; Electric Stimulation; In Vitro Techniques; Male; Mucous Membrane; Muscle Contraction; Organ Size; Protein Carbonylation; Rabbits; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2007 |
Nitrative stress in refractory asthma.
Topics: Adult; Aged; Asthma; Biomarkers; Bronchodilator Agents; Drug Resistance; Exhalation; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Sputum; Staining and Labeling; Steroids; Tyrosine; Vital Capacity; Xanthine Oxidase | 2008 |
Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Coculture Techniques; Immunohistochemistry; Mice; Mice, Knockout; Mitochondria; Neuroglia; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
H2O2/nitrite-induced post-translational modifications of human hemoglobin determined by mass spectrometry: redox regulation of tyrosine nitration and 3-nitrotyrosine reduction by antioxidants.
Topics: Amino Acid Sequence; Antioxidants; Ascorbic Acid; Cysteine; Hemin; Hemoglobins; Humans; Hydrogen Peroxide; Methionine; Molecular Sequence Data; Nitrates; Nitrites; Oxidation-Reduction; Peroxidase; Protein Processing, Post-Translational; Reactive Nitrogen Species; Spectrometry, Mass, Electrospray Ionization; Trypsin; Tyrosine; Vitamin B 12 | 2008 |
Targets of tyrosine nitration in diabetic rat retina.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Diabetic Retinopathy; Electrophoresis, Polyacrylamide Gel; Glucose Transporter Type 4; Immunoprecipitation; Male; Molecular Sequence Data; Nitrogen; Phosphorylation; Phosphotyrosine; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Proteins; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 2; Tyrosine; Vesicular Transport Proteins | 2008 |
Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus.
Topics: Animals; Brain Injuries; Disease Models, Animal; Hippocampus; Male; Oxidative Stress; Oxygen Inhalation Therapy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resuscitation; Tyrosine | 2008 |
Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction.
Topics: Animals; Apoptosis; Cardiac Catheterization; Cardiomegaly; Echocardiography; Fibrosis; Matrix Metalloproteinase 2; Membrane Glycoproteins; Mice; Mice, Knockout; Myocardial Infarction; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; RNA, Messenger; Staining and Labeling; Survival Analysis; Tyrosine; Ventricular Remodeling | 2008 |
Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints.
Topics: Aggrecans; Animals; Arthritis, Experimental; Cells, Cultured; Chondrocytes; Dose-Response Relationship, Drug; Femur; Gene Expression Regulation, Enzymologic; Injections, Intra-Articular; Interleukin-4; Mechanotransduction, Cellular; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis; Rats; Rats, Wistar; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical; Tyrosine | 2008 |
Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation.
Topics: Animals; Body Weight; Chronic Disease; Kidney; Liver Cirrhosis, Experimental; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renal Circulation; Spleen; Tyrosine | 2008 |
Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or rosuvastatin.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Cardiovascular System; Disease Models, Animal; Enalapril; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Syndrome; Motor Neurons; Neural Conduction; Neurons, Afferent; Nociceptors; Obesity; Peripheral Nerves; Pyrimidines; Rats; Rats, Zucker; Rosuvastatin Calcium; Sciatic Nerve; Sulfonamides; Superoxides; Tyrosine; Vasodilator Agents | 2008 |
The role of nitric oxide in remodeling of capillary network in rat interscapular brown adipose tissue after long-term cold acclimation.
Topics: Acclimatization; Adipose Tissue, Brown; Animals; Arginine; Capillaries; Cold Temperature; Immunohistochemistry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Statistics as Topic; Superoxide Dismutase; Time Factors; Tyrosine | 2008 |
Vascular leakage induced by exposure to arsenic via increased production of NO, hydroxyl radical and peroxynitrite.
Topics: Animals; Arsenites; Blood Vessels; Capillary Permeability; Carbon; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Evans Blue; Free Radical Scavengers; Guanidines; Hydroxyl Radical; Injections, Intradermal; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Skin; Sodium Compounds; Thiourea; Tyrosine | 2008 |
Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Dinoprostone; Ericaceae; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-6; Lipid Peroxidation; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Plant Leaves; Pleurisy; Pneumonia; STAT1 Transcription Factor; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Duodenum; Ileum; Immunohistochemistry; Injections, Intraperitoneal; Intestine, Small; Jejunum; Male; Methotrexate; Neutrophil Infiltration; Neutrophils; Nitrites; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reactive Nitrogen Species; Time Factors; Tyrosine | 2008 |
Proteasome activity as a target of hormone replacement therapy-dependent plaque stabilization in postmenopausal women.
Topics: Aged; Carotid Arteries; Carotid Artery Diseases; Down-Regulation; Endarterectomy, Carotid; Estrogen Replacement Therapy; Female; Humans; Middle Aged; NF-kappa B; Oxidative Stress; Postmenopause; Preoperative Care; Proteasome Endopeptidase Complex; Superoxides; Tyrosine; Ubiquitin; Vasculitis | 2008 |
Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities.
Topics: Animals; Apoptosis; Bystander Effect; DNA Damage; DNA, Neoplasm; Immunoenzyme Techniques; Leukemia, Myeloid, Acute; Leukemia, Radiation-Induced; Macrophages; Mice; Mice, Inbred CBA; Signal Transduction; Tumor Suppressor Protein p53; Tyrosine | 2008 |
Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite.
Topics: Blotting, Western; Cell Line, Tumor; Coculture Techniques; Epithelial Cells; Extracellular Space; Glutathione; Humans; Hydrogen Peroxide; Immunochemistry; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Peroxidase; Respiratory Mucosa; Tyrosine | 2008 |
Discovery of novel markers in allergic lung inflammation through proteomic-based technologies.
Topics: Acute Disease; Animals; Asthma; beta-N-Acetylhexosaminidases; Biomarkers; Bronchoalveolar Lavage Fluid; Calgranulin B; Electrophoresis, Gel, Two-Dimensional; Humans; Hypersensitivity, Immediate; Lectins; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Mice; Mice, Knockout; Protein Processing, Post-Translational; Proteomics; Subtraction Technique; Th2 Cells; Tyrosine | 2008 |
Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes.
Topics: Animals; Cadaver; Cell Death; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Lipid Peroxidation; Middle Aged; Nerve Degeneration; Nerve Growth Factor; Optic Nerve; Peroxynitrous Acid; Rats; Reference Values; Retinal Ganglion Cells; RNA, Messenger; Streptozocin; Tyrosine | 2008 |
Renal mitochondrial damage and protein modification in type-2 diabetes.
Topics: Animals; Cytosol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Male; Mice; Mice, Inbred C57BL; Microcirculation; Mitochondria; Mitochondrial Membranes; Oxidation-Reduction; Oxidative Stress; Permeability; Reference Values; Tyrosine | 2008 |
Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic GMP; DNA Replication; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Signal Transduction; Superoxides; Time Factors; Tyrosine; Vasodilation | 2008 |
Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma.
Topics: Aged; Aged, 80 and over; Calcium; Gene Expression Regulation, Enzymologic; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Lipid Peroxidation; Malondialdehyde; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trabecular Meshwork; Tyrosine; Up-Regulation; Vision Disorders; Visual Field Tests; Visual Fields | 2008 |
Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients.
Topics: Aged; Aging; Atherosclerosis; Collagen; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Proteasome Endopeptidase Complex; Tyrosine; Ubiquitin | 2008 |
Kidney damage after renal ablation is worsened in endothelial nitric oxide synthase -/- mice and improved by combined administration of L-arginine and antioxidants.
Topics: Animals; Antioxidants; Arginine; Blood Pressure; Disease Models, Animal; Drug Combinations; Kidney; Kidney Failure, Chronic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteinuria; Superoxides; Time Factors; Tyrosine | 2008 |
Genetically encoding protein oxidative damage.
Topics: Amino Acyl-tRNA Synthetases; Binding Sites; Escherichia coli; Models, Molecular; Molecular Conformation; Mutation; Oxidation-Reduction; RNA, Transfer; Superoxide Dismutase; Tyrosine | 2008 |
Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Endothelin-1; GATA4 Transcription Factor; In Situ Nick-End Labeling; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Knockout; Toll-Like Receptor 4; Tyrosine; Ventricular Dysfunction, Left | 2008 |
Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.
Topics: Aldehyde Reductase; Animals; Antioxidants; Arachidonic Acid; Benzothiazoles; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Hydroxyeicosatetraenoic Acids; Hypoglycemic Agents; Indomethacin; Insulin; Kidney; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Perfusion; Phthalazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Spin Labels; Tyrosine | 2008 |
Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4.
Topics: Animals; Cattle; Cell Line, Tumor; Cell Movement; Cells, Cultured; Endothelium, Vascular; Humans; Peroxynitrous Acid; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Tyrosine | 2008 |
Copper deficiency results in AMP-activated protein kinase activation and acetylCoA carboxylase phosphorylation in rat cerebellum.
Topics: Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cerebellum; Copper; Enzyme Activation; Fatty Acids; Mitochondria; Multienzyme Complexes; Nitric Oxide; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
The effects of rosiglitazone on oxidative stress and lipid profile in left ventricular muscles of diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Heart Ventricles; Lipid Metabolism; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Rosiglitazone; Streptozocin; Thiazolidinediones; Tyrosine | 2008 |
A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Brain; Cell Respiration; Cells, Cultured; Disease Models, Animal; Humans; Membrane Potential, Mitochondrial; Metalloporphyrins; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Mutation; Neurons; Oxidative Stress; Presenilin-1; Protein Carbonylation; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2008 |
Differential patterns of peroxynitrite mediated apoptosis in proximal tubular epithelial cells following ATP depletion recovery.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Enzyme Activation; L-Lactate Dehydrogenase; LLC-PK1 Cells; Metalloporphyrins; Mitochondria; Models, Animal; Peroxynitrous Acid; Reperfusion Injury; Swine; Tyrosine | 2008 |
Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit.
Topics: Acetylcholine; Angiotensin II; Animals; Biopterins; Biosensing Techniques; Blood Pressure; Calibration; Catheterization; Enzyme Inhibitors; Heart Rate; Hypoglycemic Agents; Immunohistochemistry; Male; Nitric Oxide; omega-N-Methylarginine; Pioglitazone; PPAR gamma; Rabbits; Thiazolidinediones; Tyrosine; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Effects of long-term exposure of extremely low frequency magnetic field on oxidative/nitrosative stress in rat liver.
Topics: Animals; Female; Liver; Magnetics; Male; Nitrosation; Oxidative Stress; Rats; Rats, Wistar; Stress, Physiological; Tyrosine | 2008 |
Alcohol-induced oxidative stress in the liver: in vivo measurements.
Topics: Aldehydes; Animals; Biomarkers; Disease Models, Animal; Immunohistochemistry; Lipopolysaccharides; Liver; Liver Diseases, Alcoholic; Mice; Mice, Transgenic; Oxidative Stress; Photomicrography; Proteins; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Reproducibility of Results; Signal Processing, Computer-Assisted; Specimen Handling; Tyrosine | 2008 |
Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress.
Topics: Aging; Aldehydes; Animals; Autophagy; Energy Metabolism; Heating; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Mitochondria; Oxidative Stress; Peroxisomes; Proteins; Rats; Rats, Inbred F344; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2008 |
First evidence for an LDL- and HDL-associated nitratase activity that denitrates albumin-bound nitrotyrosine--physiological consequences.
Topics: Calcium; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Oxidoreductases; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2008 |
Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diet; Electron Transport Complex III; Intercellular Adhesion Molecule-1; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Inbred Lew; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vascular Endothelial Growth Factor A; Xanthophylls; Zeaxanthins | 2008 |
Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Arginine; Cells, Cultured; HSP90 Heat-Shock Proteins; Humans; Ion Channels; Mitochondria; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Protein Transport; Pulmonary Artery; Recombinant Proteins; Sheep; Signal Transduction; Superoxides; Tyrosine; Uncoupling Protein 2 | 2008 |
Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Creatinine; Cystatin C; Cystatins; Dinoprostone; Disease Models, Animal; Hyperoxia; Kidney; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Shock, Hemorrhagic; Transcription Factor RelA; Tyrosine; Urea | 2008 |
Nano titanium dioxide photocatalytic protein tyrosine nitration: a potential hazard of TiO2 on skin.
Topics: Animals; Antioxidants; Catalysis; Cattle; Environment; Mice; Nanostructures; Nitrites; Oxidative Stress; Protein Processing, Post-Translational; Serum Albumin, Bovine; Skin; Skin Diseases; Sunscreening Agents; Titanium; Tyrosine; Ultraviolet Rays | 2008 |
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Estradiol; Heart Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Mitogen-Activated Protein Kinase 11; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Function | 2008 |
Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide.
Topics: Animals; Cyclic GMP; Down-Regulation; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Lipopolysaccharides; Macrophages; Mice; NIH 3T3 Cells; Nitric Oxide; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction; Subcellular Fractions; Transcriptional Activation; Tyrosine | 2008 |
Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.
Topics: Animals; Escherichia coli; Escherichia coli Infections; Gene Expression Regulation, Enzymologic; Lung; Lung Injury; Mice; Mice, Knockout; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidants; Peroxidase; Pulmonary Edema; Sepsis; Tyrosine | 2008 |
Conversion of tyrosine to the inflammation-associated analog 3'-nitrotyrosine at either TCR- or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T ce
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Epitopes, T-Lymphocyte; Glycoproteins; Histocompatibility Antigens Class I; Hybridomas; Immunization; Lymphocytic choriomeningitis virus; Mice; Mice, Transgenic; Peptides; Receptors, Antigen, T-Cell; Tyrosine; Viral Proteins | 2008 |
Analysis of oxidative modification of proteins.
Topics: Biochemistry; Borohydrides; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Iodoacetamide; Isoaspartic Acid; Mass Spectrometry; Oxidation-Reduction; Phenylhydrazines; Protein Carbonylation; Proteins; Reference Standards; Spectrophotometry; Sulfhydryl Compounds; Tritium; Tyrosine | 2001 |
Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration.
Topics: Animals; Atherosclerosis; Cattle; Cell Culture Techniques; Cells, Cultured; Chromatography, High Pressure Liquid; Computer Simulation; Coronary Vessels; Endothelial Cells; Hemorheology; Humans; Immunohistochemistry; Lipoproteins, LDL; Models, Cardiovascular; Pulsatile Flow; RNA Interference; RNA, Messenger; Stress, Mechanical; Superoxide Dismutase; Tandem Mass Spectrometry; Tissue Culture Techniques; Tyrosine | 2008 |
Effects of postresuscitation N-acetylcysteine on cerebral free radical production and perfusion during reoxygenation of hypoxic newborn piglets.
Topics: Acetylcysteine; Animals; Animals, Newborn; Carotid Arteries; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Glutathione; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; Lactates; Nitric Oxide; Oxidative Stress; Oxygen; Random Allocation; Regional Blood Flow; Swine; Tyrosine | 2008 |
Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amnesia; Apoptosis; Brain; Cognition Disorders; Female; Humans; Male; Nitrogen; Oxidation-Reduction; Oxidative Stress; Protein Binding; Tumor Suppressor Protein p53; Tyrosine | 2008 |
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dose-Response Relationship, Radiation; Electron Transport Complex IV; Infrared Rays; Lasers, Semiconductor; Male; Neurons; Neurotoxins; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Tyrosine | 2008 |
Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Endothelial Cells; Endothelin-1; Epoprostenol; Free Radical Scavengers; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophils; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Kinase Inhibitors; Time Factors; Tyrosine; Up-Regulation | 2008 |
Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine.
Topics: Animals; Antigens; Apoptosis; Biomarkers; Cell Adhesion Molecules; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Gentamicins; Immunoenzyme Techniques; Immunohistochemistry; Kidney; Kidney Tubules, Proximal; Male; Mercuric Chloride; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Potassium Dichromate; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation; Xenobiotics | 2008 |
Effect of pitavastatin on type 2 diabetes mellitus nephropathy in KK-Ay/Ta mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; GTP Cyclohydrolase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Quinolines; RNA, Messenger; Tyrosine | 2008 |
Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines.
Topics: Adipokines; Adiponectin; Adult; Age of Onset; Aged; Diabetes Mellitus, Type 2; Diet; E-Selectin; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Inpatients; Leptin; Male; Middle Aged; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Tyrosine | 2008 |
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Antioxidants; Aorta; Biopterins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Glutathione; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Proviruses; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Superoxides; Thiazolidines; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2008 |
Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress.
Topics: Acetylcholine; Anemia, Sickle Cell; Animals; Arginine; Citrulline; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Globins; Heme Oxygenase-1; Hemodynamics; Hemoglobins; Hemolysis; Humans; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Tyrosine; Vasodilator Agents | 2008 |
Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation.
Topics: Aorta; Biological Transport; Cell Movement; Cells, Cultured; Enzyme Activation; Humans; Integrins; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADP; Oxidative Stress; Reactive Oxygen Species; Receptor, Platelet-Derived Growth Factor beta; Tyrosine | 2008 |
Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat.
Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Fumarates; Irbesartan; Male; Myocardium; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin; Tetrazoles; Tyrosine; Ventricular Remodeling | 2008 |
Constitutive intracellular production of iNOS and NO in human melanoma: possible role in regulation of growth and resistance to apoptosis.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Humans; Melanoma; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; STAT3 Transcription Factor; Tumor Cells, Cultured; Tyrosine | 2008 |
Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Activating Transcription Factor 4; Animals; Cell Survival; Cells, Cultured; Deoxyguanosine; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Glucose; Insulin-Secreting Cells; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Psychological; Transcription Factor CHOP; Tyrosine | 2008 |
Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis.
Topics: Acetylcysteine; Animals; Antioxidants; Bile Ducts; Disease Models, Animal; Free Radical Scavengers; Ligation; Liver Circulation; Liver Cirrhosis, Biliary; Liver Function Tests; Male; Microcirculation; Oxidants; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Thromboxane-A Synthase; Tyrosine; Vascular Resistance | 2008 |
Ecstasy produces left ventricular dysfunction and oxidative stress in rats.
Topics: Animals; Calcium Signaling; Cells, Cultured; Diastole; Dilatation, Pathologic; Electric Stimulation; Hallucinogens; Heart Ventricles; Injections, Intravenous; Kinetics; Male; Muscle Proteins; Myocardial Contraction; Myocytes, Cardiac; N-Methyl-3,4-methylenedioxyamphetamine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Systole; Tyrosine; Ultrasonography; Ventricular Dysfunction, Left | 2008 |
Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipidemic rabbits.
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Atherosclerosis; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Heart Rate; Hyperlipidemias; Losartan; Male; Nitric Oxide; Peroxynitrous Acid; Rabbits; Tyrosine; Vasodilator Agents | 2008 |
The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology.
Topics: Anemia, Sickle Cell; Animals; Arginine; Disease Models, Animal; Hemodynamics; Hemoglobins; Hemolysis; Humans; Microcirculation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Tyrosine; Vasodilator Agents | 2008 |
Effect of pioglitazone on nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor.
Topics: Acetylcholine; Animals; Biopterins; Calibration; Catheterization; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Hypoglycemic Agents; Male; Models, Animal; Nitric Oxide; Nitroglycerin; Pioglitazone; PPAR gamma; Rabbits; Thiazolidinediones; Tyrosine; Vasodilator Agents | 2008 |
Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept.
Topics: Acute Disease; Animals; Biomarkers; Carrageenan; Edema; Etanercept; Fas Ligand Protein; Gene Deletion; Hindlimb; Immunoglobulin G; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-1; Lung; Male; Mice; Mice, Knockout; Models, Animal; P-Selectin; Pleurisy; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.
Topics: Aldehyde Reductase; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blood Glucose; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glial Fibrillary Acidic Protein; Imidazolidines; Immunohistochemistry; In Situ Nick-End Labeling; Neuroglia; Ophthalmoscopy; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Retina; Streptozocin; Tyrosine | 2008 |
Effects of quercetin on hyper-proliferation of gastric mucosal cells in rats treated with chronic oral ethanol through the reactive oxygen species-nitric oxide pathway.
Topics: Administration, Oral; Animals; Antioxidants; Blotting, Western; Cell Proliferation; Cyclin D; Cyclins; Ethanol; Flavonoids; Gastric Mucosa; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Proliferating Cell Nuclear Antigen; Protein Carbonylation; Quercetin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Tyrosine | 2008 |
Photoreceptor oxidative damage in sympathetic ophthalmia.
Topics: Acrolein; Adult; Aged; Apoptosis; Biomarkers; Cytochromes c; Fluorescent Antibody Technique, Indirect; Humans; In Situ Nick-End Labeling; Middle Aged; Mitochondrial Diseases; Nitric Oxide Synthase Type II; Ophthalmia, Sympathetic; Oxidative Stress; Photoreceptor Cells, Vertebrate; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Effects of antioxidant stobadine on protein carbonylation, advanced oxidation protein products and reductive capacity of liver in streptozotocin-diabetic rats: role of oxidative/nitrosative stress.
Topics: Animals; Antioxidants; Carbolines; Diabetes Mellitus, Experimental; Liver; Male; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Streptozocin; Sulfhydryl Compounds; Tyrosine | 2007 |
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Topics: Adult; Aged; Aged, 80 and over; Arginase; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Italy; Lung Neoplasms; Male; Microscopy, Confocal; Middle Aged; Neoplasm Staging; Nitric Oxide Synthase; Nitrites; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tyrosine | 2008 |
Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.
Topics: Androgen Antagonists; Animals; Apoptosis; Blotting, Western; Cell Separation; Chemokines; Cytokines; DNA Fragmentation; Flutamide; Glutathione Transferase; Hemorrhage; Hepatitis; Hepatocytes; Hypoxia-Inducible Factor 1, alpha Subunit; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C3H; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Tyrosine | 2008 |
Immunoaffinity liquid chromatography-tandem mass spectrometry detection of nitrotyrosine in biological fluids: development of a clinically translatable biomarker.
Topics: Antibodies; Biomarkers; Body Fluids; Chromatography, Affinity; Linear Models; Pronase; Reproducibility of Results; Sensitivity and Specificity; Synovial Fluid; Tandem Mass Spectrometry; Tyrosine | 2008 |
Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blood Glucose; Body Weight; Deoxyguanosine; Disease Models, Animal; Inflammation; Insulin; Lipids; Lipoproteins, LDL; Metabolic Syndrome; Oxidative Stress; Peroxidase; Rats; Rats, Inbred SHR; Tyrosine; Ubiquinone | 2008 |
Cerebrospinal fluid, serum and plasma protein oxidation in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Blood Proteins; Cerebrospinal Fluid Proteins; Female; Humans; Male; Middle Aged; Nitroso Compounds; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Reference Values; Tyrosine | 2009 |
Lack of IFN-gamma synthesis in aqueous humor during corneal graft rejection correlates with suppressed nitric oxide production by macrophages.
Topics: Animals; Aqueous Humor; Corneal Transplantation; Disease Models, Animal; Female; Flow Cytometry; Graft Rejection; Interferon-gamma; Interleukin-10; Macrophages; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy.
Topics: Amyloid Neuropathies, Familial; Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; fas Receptor; Gastrointestinal Tract; Heat-Shock Proteins; Humans; Immunohistochemistry; Methionine; Mice; Mice, Transgenic; Molecular Chaperones; Mutant Proteins; Mutation; Oxidation-Reduction; Prealbumin; Protein Structure, Quaternary; Taurochenodeoxycholic Acid; Thermodynamics; Tyrosine | 2008 |
Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver.
Topics: Acetaminophen; Animals; Catalysis; Cattle; Genotype; Lipopolysaccharides; Liver; Mice; Mice, Knockout; Nitrogen; Nitrogen Oxides; Substrate Specificity; Superoxide Dismutase; Tyrosine | 2008 |
Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Enzyme Activation; Glycyrrhizic Acid; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipid Peroxidation; Lung; Male; Mice; Neutrophils; NF-kappa B; P-Selectin; Peroxynitrous Acid; Pleurisy; Poly Adenosine Diphosphate Ribose; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.
Topics: Aging; Animals; Cytosol; Dopamine Plasma Membrane Transport Proteins; Fluorescent Antibody Technique; Immunohistochemistry; Macaca mulatta; Nerve Degeneration; Neurons; Substantia Nigra; Tyrosine; Ventral Tegmental Area; Vesicular Monoamine Transport Proteins | 2008 |
Endothelial and vascular dysfunctions and insulin resistance in rats fed a high-fat, high-sucrose diet.
Topics: Animals; Blood Pressure; Blotting, Western; Body Weight; Deoxyglucose; Diet; Dietary Fats; Endothelin-1; Endothelium, Vascular; Fatty Acids, Nonesterified; Fluorescent Antibody Technique; Glucose Clamp Technique; Heart Rate; Insulin; Insulin Resistance; Male; Obesity; Organ Size; Rats; Rats, Sprague-Dawley; Sucrose; Triglycerides; Tyrosine; Vascular Diseases; Vascular Resistance | 2008 |
Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells.
Topics: Apoptosis; Cell Line, Tumor; Cytosol; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Fluorescent Antibody Technique, Direct; Humans; Mitochondria; Neuroblastoma; NG-Nitroarginine Methyl Ester; Nitrogen; Piperazines; Rotenone; Time Factors; Tyrosine; Uncoupling Agents; Vesicular Monoamine Transport Proteins | 2008 |
Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis.
Topics: Blotting, Western; Cell Proliferation; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Ki-67 Antigen; Lung; Male; Mass Spectrometry; Middle Aged; Oxidative Stress; Peroxiredoxins; Pulmonary Fibrosis; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Tyrosine | 2008 |
Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge.
Topics: Aldehydes; Animals; Anti-Bacterial Agents; Brain-Derived Neurotrophic Factor; Calcium Channels; Ear, Inner; Ganglia, Spinal; Gentamicins; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Mice; Mice, Inbred CBA; Microscopy, Fluorescence; Nerve Fibers; Organ of Corti; Semicircular Ducts; Sensory Receptor Cells; Spiral Ganglion; Stria Vascularis; Trigeminal Ganglion; TRPV Cation Channels; Tyrosine; Vestibular Nerve | 2009 |
L-Arginine decreases fluid-percussion injury-induced neuronal nitrotyrosine immunoreactivity in rats.
Topics: Animals; Arginine; Brain Injuries; Cerebral Cortex; Hippocampus; Immunohistochemistry; Male; Neurons; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage.
Topics: Animals; Brain Edema; CD18 Antigens; Cerebral Hemorrhage; Immunohistochemistry; Male; Mice; Mice, Knockout; Peroxidase; Reperfusion Injury; Tyrosine | 2008 |
Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Ischemia; Caspase 3; Caspase 9; Chromatography, High Pressure Liquid; Dapsone; Immunoblotting; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Neuroprotective Agents; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2008 |
The immediate effect of nitric oxide on the rabbit bladder after ovariectomy.
Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Carbachol; Female; Free Radicals; Isometric Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Oxidative Stress; Potassium Chloride; Protein Carbonylation; Rabbits; Reperfusion Injury; Tyrosine; Urinary Bladder; Urination | 2008 |
Increased levels of urinary nitrite and nitrotyrosine in Yusho victims 40 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.
Topics: Adult; Aged; Disease Outbreaks; Environmental Pollutants; Female; Food Contamination; Foodborne Diseases; Humans; Japan; Male; Middle Aged; Nitrites; Oryza; Plant Oils; Poisoning; Polychlorinated Biphenyls; Tyrosine | 2008 |
Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria.
Topics: Animals; Apoptosis; Blotting, Western; Bongkrekic Acid; Cyclosporine; Cytochromes c; Diamide; Dimerization; Disulfides; Dithiothreitol; Enzyme Activation; Galactosamine; Glutathione; Glutathione Transferase; Lipopolysaccharides; Male; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reducing Agents; Sulfhydryl Reagents; Time Factors; Tyrosine | 2008 |
Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Chemokines; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fluid Therapy; Glutathione Transferase; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion Molecule-1; Isoenzymes; Liver; Liver Diseases; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Tyrosine; Wounds and Injuries | 2008 |
Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cardiotonic Agents; Cell Nucleus; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Hydroxy Acids; Male; Malondialdehyde; Muscle Proteins; Myocardial Reperfusion Injury; Neutrophils; Phosphorylation; Rats; Rats, Wistar; Sulfides; Tyrosine | 2009 |
Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.
Topics: Animals; Brain; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Disease Models, Animal; Heart Arrest; Hypothermia, Induced; Male; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2008 |
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Atherosclerosis; Biopterins; Blood Pressure; Drug Therapy, Combination; Endothelium, Vascular; Fumarates; Heart Rate; HSP90 Heat-Shock Proteins; Hyperlipidemias; Inflammation Mediators; Lipids; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rabbits; Renin; Tetrazoles; Tyrosine; Valine; Valsartan; Vasodilation; Vasodilator Agents | 2008 |
[Relationship between islet beta cell dysfunction and gene expression of uncoupling protein-2 and possible mechanism thereof].
Topics: Animals; Cells, Cultured; Dietary Fats; Gene Expression; Glutathione; Immunohistochemistry; Insulin; Insulin Receptor Substrate Proteins; Ion Channels; Islets of Langerhans; Male; Malondialdehyde; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine; Uncoupling Protein 2 | 2008 |
Simultaneous detection and quantification of 3-nitrotyrosine and 3-bromotyrosine in human urine by stable isotope dilution liquid chromatography tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Radioisotope Dilution Technique; Sensitivity and Specificity; Tandem Mass Spectrometry; Tyrosine | 2008 |
The peroxynitrite donor 3-morpholinosydnonimine induces reversible changes in electrophysiological properties of neurons of the guinea-pig spinal cord.
Topics: Action Potentials; Animals; Axons; Cell Membrane; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Guinea Pigs; Molsidomine; Nerve Degeneration; Neural Conduction; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Peroxynitrous Acid; Sodium Channels; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2008 |
Glycyrrhizin reduces secondary inflammatory process after spinal cord compression injury in mice.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Glycyrrhizic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Male; Mice; Mice, Inbred Strains; Motor Activity; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Tyrosine | 2009 |
Estrogen administration attenuates bladder outlet obstruction induced oxidative stress in the female rabbit.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Carbachol; Choline O-Acetyltransferase; Cholinergic Agonists; Disease Models, Animal; Drug Administration Schedule; Electric Stimulation; Estradiol; Estrogens; Female; Injections, Subcutaneous; Muscle Contraction; Oxidative Stress; Potassium Chloride; Protein Carbonylation; Rabbits; Superoxide Dismutase; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2009 |
Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage.
Topics: Analysis of Variance; Animals; Brain Edema; Calcium-Binding Proteins; Cerebral Hemorrhage; Cytochromes c; Disease Models, Animal; Encephalitis; Fluoresceins; Functional Laterality; Glial Fibrillary Acidic Protein; Granulocyte Colony-Stimulating Factor; Heme Oxygenase (Decyclizing); Interleukin-3; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Nerve Degeneration; Organic Chemicals; Recombinant Fusion Proteins; Recombinant Proteins; Spectrophotometry; Time Factors; Tyrosine | 2008 |
Denitration of L-type calcium channel.
Topics: Animals; Calcium Channels, L-Type; Cell Line; Humans; Mice; Muscle, Smooth; Nitrates; Phosphorylation; Tyrosine | 2008 |
Ascorbic acid protects the newborn rat brain from hypoxic-ischemia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Apoptosis; Ascorbic Acid; Blotting, Western; Brain; Brain Ischemia; Calpain; Carrier Proteins; Caspase 3; Enzyme Activation; In Situ Nick-End Labeling; Microfilament Proteins; Microscopy, Electron; Necrosis; Neurons; Neuroprotective Agents; Rats; Tyrosine | 2009 |
Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium.
Topics: Animals; Cattle; Electron Transport Complex II; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2008 |
Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells.
Topics: Analysis of Variance; Blotting, Western; Cells, Cultured; Coronary Vessels; Cyclic GMP; Dietary Supplements; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Endothelial Cells; Female; HSP90 Heat-Shock Proteins; Humans; Male; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; Tyrosine; Vascular Endothelial Growth Factors | 2008 |
Enhanced nitrosative stress during Trypanosoma cruzi infection causes nitrotyrosine modification of host proteins: implications in Chagas' disease.
Topics: Animals; Biomarkers; Blood Proteins; Blotting, Western; Chagas Cardiomyopathy; Comet Assay; Electrophoresis, Gel, Two-Dimensional; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Mice; Myocardium; Nitrosation; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypanosoma cruzi; Tyrosine | 2008 |
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.
Topics: Adenosine Diphosphate; Animals; Corpus Striatum; Dizocilpine Maleate; Drug Interactions; Male; Memantine; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nitro Compounds; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2009 |
Interaction between COX-2 and iNOS aggravates vascular lesion and antagonistic effect of ginsenoside.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Endothelium, Vascular; Gene Expression; Ginsenosides; Immunoprecipitation; Male; Medicine, Chinese Traditional; Microscopy, Confocal; Nitric Oxide Synthase Type II; Panax; Peroxynitrous Acid; Plant Roots; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2008 |
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia.
Topics: Aldehydes; Angiotensin II; Animals; Antioxidants; Arterioles; Body Weight; Cyclic N-Oxides; Disease Models, Animal; Glomerular Filtration Rate; Hypertension, Renal; Hyperuricemia; Kidney Glomerulus; Male; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Oxonic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Spin Labels; Superoxides; Tyrosine | 2008 |
Lifelong running reduces oxidative stress and degenerative changes in the testes of mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blotting, Western; Deoxyguanosine; Histones; Immunohistochemistry; Leydig Cells; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Testis; Testosterone; Tyrosine | 2008 |
Intermittent hypoxia has organ-specific effects on oxidative stress.
Topics: Acetophenones; Animals; Body Weight; Eating; Enzyme Inhibitors; Erythrocytes; Glutathione; Glutathione Disulfide; Hypoxia; Lipid Peroxidation; Lipoproteins, LDL; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NADPH Oxidases; Oxidative Stress; Phosphorylation; Superoxide Dismutase; Tyrosine | 2008 |
Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury.
Topics: 2,4-Dinitrophenol; Aldehydes; Animals; Antioxidants; Cell Respiration; Cyclic N-Oxides; Disease Models, Animal; Electron Transport Complex I; Energy Metabolism; Female; Mitochondria; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Spin Labels; Spinal Cord Diseases; Time Factors; Tyrosine; Uncoupling Agents | 2009 |
Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells.
Topics: Angiotensin II; Cell Nucleus; Cells, Cultured; Diabetic Nephropathies; Epithelial Cells; Gene Expression; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Kidney Tubules, Proximal; NF-kappa B; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Rosiglitazone; Thiazolidinediones; Tyrosine | 2008 |
LDL protein nitration: implication for LDL protein unfolding.
Topics: Animals; Aorta; Apolipoprotein B-100; Cattle; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Models, Chemical; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Protein Conformation; Protein Denaturation; Protein Processing, Post-Translational; Protein Structure, Secondary; Proteins; Reproducibility of Results; Tyrosine | 2008 |
Combined effects of an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and angiotensin II receptor antagonist on nitric oxide bioavailability and atherosclerotic change in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Atherosclerosis; Biological Availability; Drug Therapy, Combination; Echocardiography; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Myocardial Infarction; Nitric Oxide; Quinolines; Rabbits; Reactive Oxygen Species; Tetrazoles; Tyrosine; Valine; Valsartan | 2008 |
[Nitric oxide metabolites and their significance in pathogenesis of bronchial asthma].
Topics: Asthma; Biomarkers; Bronchoalveolar Lavage Fluid; Catalase; Glutathione; Humans; Malondialdehyde; Nitric Oxide; Nitrites; Respiratory System; Superoxide Dismutase; Tyrosine | 2008 |
Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma.
Topics: Actins; Aged; Aged, 80 and over; Antigens, CD34; Biomarkers; Blood Vessels; Glaucoma, Open-Angle; Glial Fibrillary Acidic Protein; Humans; Middle Aged; Neuroglia; Optic Disk; Oxidative Stress; Tyrosine | 2008 |
High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo.
Topics: Animals; Cell Respiration; Cytochrome P-450 CYP2E1; Dietary Fats; Fatty Liver; Hypoxia; Liver; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Tyrosine | 2009 |
Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria.
Topics: Aldehydes; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Pressure; Glomerular Filtration Rate; Glutathione Reductase; Hypertension, Renal; Kidney; Kidney Glomerulus; Male; Nitric Oxide Synthase Type II; Organ Size; Oxidative Stress; Peroxidases; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Renal Plasma Flow; Superoxide Dismutase; Thiocarbamates; Transcription Factor RelA; Tyrosine | 2008 |
Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
Topics: Age Factors; Aging; Aldehydes; Animals; Carbonic Anhydrase III; Hindlimb Suspension; LIM Domain Proteins; Male; Muscle Proteins; Muscle, Skeletal; Oxidation-Reduction; Proteomics; Rats; Rats, Inbred F344; Time Factors; Tyrosine | 2008 |
Tags for labeling protein N-termini with subtiligase for proteomics.
Topics: Alkynes; Amino Acid Sequence; Enzyme-Linked Immunosorbent Assay; Glycine; Humans; Isotope Labeling; Jurkat Cells; Peptide Synthases; Proteins; Proteomics; Solubility; Structure-Activity Relationship; Substrate Specificity; Subtilisins; Tyrosine | 2008 |
Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Catalysis; Diabetic Neuropathies; Glutathione; Male; Metalloporphyrins; Neural Conduction; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Tyrosine | 2008 |
Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Blood Glucose; Body Weight; Deoxyguanosine; Diabetic Nephropathies; Disease Progression; Glycated Hemoglobin; Immunohistochemistry; Male; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Taurine; Tyrosine | 2008 |
Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Energy Metabolism; Enzymes; Liver; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Nitric Oxide Synthase Type II; Nitrites; Nitrogen; Oxidation-Reduction; Oxidative Stress; Reperfusion Injury; Sequence Analysis, Protein; Superoxide Dismutase; Tandem Mass Spectrometry; Tyrosine | 2008 |
Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients.
Topics: Animals; Ascorbic Acid; beta Carotene; Body Weight; Copper; Deoxyadenosines; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diet; Eating; Electron Transport Complex III; Glycated Hemoglobin; Immunoenzyme Techniques; Male; Micronutrients; Nitric Oxide Synthase Type II; Oxidative Stress; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; Retinal Vessels; RNA, Messenger; Superoxide Dismutase; Tyrosine; Vitamin E; Zinc Oxide | 2008 |
Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases.
Topics: Caspase 3; Cell Death; Cell Survival; Dose-Response Relationship, Drug; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrites; Phosphorylation; S-Nitrosoglutathione; S-Nitrosothiols; Signal Transduction; Thioredoxins; Tyrosine; Up-Regulation | 2008 |
Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications.
Topics: Alanine; Animals; Enzyme Inhibitors; Ethanol; Extracellular Signal-Regulated MAP Kinases; Gastric Mucosa; Liver Cirrhosis; MAP Kinase Kinase Kinases; Nitrates; Oxidative Stress; Peroxynitrous Acid; Quinolones; Rats; Rats, Sprague-Dawley; Signal Transduction; Stomach Diseases; Tyrosine | 2008 |
Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading.
Topics: Aging; Animals; Blotting, Western; Catalase; Female; Hindlimb Suspension; Hydrogen Peroxide; Male; Malondialdehyde; Muscle, Skeletal; Organ Size; Oxidative Stress; Rats; Rats, Inbred BN; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Tyrosine | 2008 |
Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Blotting, Western; Chemokine CCL2; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Immunohistochemistry; Inflammation Mediators; Kidney; Male; Nephritis; Nitric Oxide Synthase Type II; Oxidative Stress; Piperazines; Purines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sildenafil Citrate; Streptozocin; Sulfones; Tyrosine; Vasodilator Agents | 2009 |
Proteomic analysis of brain protein expression levels in NF-kappabeta p50 -/- homozygous knockout mice.
Topics: Aldehydes; Animals; Brain; Electrophoresis, Gel, Two-Dimensional; Image Processing, Computer-Assisted; Male; Mass Spectrometry; Mice; Mice, Knockout; NF-kappa B p50 Subunit; Oxidative Stress; Proteomics; Tyrosine | 2008 |
Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity.
Topics: Acrolein; Aldehydes; Analysis of Variance; Blotting, Western; Cell Line, Tumor; Cell Survival; Cytotoxins; Flavonoids; Free Radicals; Glutathione; Humans; Lipid Peroxidation; Luminescence; NADPH Oxidases; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Protein Carbonylation; Tyrosine | 2008 |
D-glucose induces microtubular changes in C1300 neuroblastoma cell line through the incorporation of 3-nitro-L-tyrosine into tubulin.
Topics: Actins; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytoskeleton; Down-Regulation; Energy Metabolism; Glucose; Hyperglycemia; Mice; Microtubules; Nerve Degeneration; Neuroblastoma; Neurons; Oxidative Stress; Tubulin; Tyrosine | 2008 |
CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis.
Topics: Carcinoma, Papillary; Cell Line, Tumor; Chemokine CXCL12; Enzyme Inhibitors; Humans; Immunohistochemistry; Lymphatic Metastasis; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroso Compounds; Receptors, CXCR4; RNA, Messenger; Thyroid Neoplasms; Tyrosine | 2008 |
Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model.
Topics: Animals; Carbon Monoxide; Disease Models, Animal; Erythrocytes; Hemoglobins; Liver; Lung; Male; Rats; Rats, Wistar; Resuscitation; Shock, Hemorrhagic; Tyrosine | 2009 |
Effect of nitric oxide on auditory cortical neurons of aged rats.
Topics: Age Factors; Aging; Animals; Auditory Cortex; In Vitro Techniques; Male; Membrane Potentials; NADP; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
[Protective effect of nourishingyin and promoting blood flow recipe on kidney of diabetic rat].
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Immunohistochemistry; Kidney; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Tyrosine | 2008 |
Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Decanoic Acids; Dogs; Female; Hydroxy Acids; Male; Myocardial Reperfusion Injury; Peroxynitrous Acid; Potassium Channels; Severity of Illness Index; Survival Rate; Tyrosine; Ventricular Fibrillation | 2008 |
Exogenous superoxide dismutase prevents peroxynitrite-induced apoptosis in non-heart-beating donor livers.
Topics: Alanine Transaminase; Animals; Apoptosis; Glutamate Dehydrogenase; Immunohistochemistry; Liver; Male; Peroxynitrous Acid; Portal Vein; Rats; Rats, Wistar; Superoxide Dismutase; Tissue Donors; Tyrosine | 2008 |
p38MAPK and ERK promote nitric oxide production in cultured human retinal pigmented epithelial cells induced by high concentration glucose.
Topics: Biomarkers; Cell Line; Diabetic Retinopathy; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glucose; Humans; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Reactive Nitrogen Species; Reactive Oxygen Species; Retinal Pigment Epithelium; Superoxide Dismutase; Tyrosine | 2009 |
Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Injections, Intraperitoneal; Male; Microglia; Neuroprotective Agents; Nicotine; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2009 |
Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome.
Topics: Animals; Aorta, Abdominal; Apoptosis; Carotid Artery Injuries; Cell Cycle; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperplasia; Male; Metabolic Syndrome; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Proline; Rats; Rats, Zucker; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Triazenes; Tyrosine | 2008 |
Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion.
Topics: Acute Disease; Animals; Antioxidants; Apoptosis; Calbindin 2; Disease Models, Animal; In Situ Nick-End Labeling; Lutein; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Oxidative Stress; Poly Adenosine Diphosphate Ribose; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; S100 Calcium Binding Protein G; Tyrosine | 2009 |
Effects of fine carbonaceous particles containing high and low unpaired electron spin densities on lungs of female mice.
Topics: Aerosols; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Inhalation Exposure; Leukotriene B4; Lung; Macrophages, Alveolar; Mice; Mitochondria; Nitric Oxide; Oxidative Stress; Particulate Matter; Soot; Tyrosine | 2008 |
Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Fas Ligand Protein; Gene Expression Regulation; Humans; Inflammation; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; Pyruvates; Spinal Cord Injuries; Time Factors; Tyrosine | 2009 |
Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity.
Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Catalysis; Hemodynamics; Interleukin-2; Lung; Lymph; Malondialdehyde; Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Pulmonary Gas Exchange; Recombinant Proteins; Sheep; Tyrosine | 2008 |
Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cisplatin; Disease Models, Animal; Free Radical Scavengers; Glutathione; Kidney; Kidney Diseases; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Tyrosine | 2009 |
Circulating white blood cells and platelets amplify oxidative stress in heart failure.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Platelets; Case-Control Studies; Cell Separation; Cytosol; Female; Flow Cytometry; Heart Failure; Humans; Leukocytes; Male; Microscopy, Fluorescence; Middle Aged; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2008 |
Intensive exercise induces changes of endothelial nitric oxide synthase pattern in human erythrocytes.
Topics: Adult; Creatine Kinase; Down-Regulation; Erythrocytes; Exercise; Hockey; Humans; Immunohistochemistry; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Tyrosine; Urea | 2009 |
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model.
Topics: Amino Acids; Animals; Blotting, Western; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intra-Abdominal Fat; Liver; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Inbred F344; RNA, Messenger; Tyrosine | 2010 |
Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung injury.
Topics: Acute Lung Injury; Amidines; Animals; Apoptosis; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Candida; Candidiasis; Caspase 3; Fas Ligand Protein; Heterocyclic Compounds, 2-Ring; Humans; In Situ Nick-End Labeling; Lung; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Survival Rate; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
Nitric oxide system alteration at spinal cord as a result of perinatal asphyxia is involved in behavioral disabilities: hypothermia as preventive treatment.
Topics: Analysis of Variance; Animals; Animals, Newborn; Asphyxia Neonatorum; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Female; Forelimb; Humans; Hypothermia, Induced; Immunohistochemistry; Infant, Newborn; Motor Activity; Motor Neurons; Muscle Tonus; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Rats; Spinal Cord; Tyrosine | 2009 |
Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cyclophosphamide; Cystitis; Hemorrhage; Immunoenzyme Techniques; Male; Malondialdehyde; NAD; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine; Urinary Bladder | 2009 |
Elevated circulating levels of soluble CD-40 ligand in haemodialysis patients with symptomatic coronary heart disease.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Case-Control Studies; CD40 Ligand; Coronary Disease; Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Kidney Failure, Chronic; Lipids; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Pilot Projects; Protein Carbonylation; Renal Dialysis; Tyrosine; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2008 |
Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice.
Topics: Animals; Collagen; Cystathionine beta-Synthase; Endothelium, Vascular; Genotype; Homocysteine; Hypertrophy, Left Ventricular; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Muscle Cells; Nitric Oxide Synthase Type II; Phenotype; Tyrosine; Ventricular Remodeling | 2009 |
Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis.
Topics: Adult; Aged; Aged, 80 and over; Alkenes; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Invasiveness; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prognosis; Receptors, CXCR4; Tyrosine | 2008 |
Pollution induced nitrative stress and heat shock protein 70 overexpression in fish liver mitochondria.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blotting, Western; Ecosystem; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; Liver; Mitochondria, Liver; Nitric Oxide; Smegmamorpha; Superoxide Dismutase; Tyrosine; Water Pollutants, Chemical | 2009 |
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine | 2008 |
Increased nitrotyrosine plasma levels in relation to systemic markers of inflammation and myeloperoxidase in chronic heart failure.
Topics: Aged; Biomarkers; Chronic Disease; Cohort Studies; Female; Heart Failure; Humans; Inflammation Mediators; Male; Middle Aged; Peroxidase; Tyrosine | 2009 |
Pigment epithelium-derived factor (PEDF) inhibits collagen-induced platelet activation by reducing intraplatelet nitrotyrosine levels.
Topics: Blood Platelets; Eye Proteins; Nerve Growth Factors; Nitric Oxide; Platelet Activation; Protease Inhibitors; Serpins; Tyrosine | 2010 |
Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biomarkers; Biphenyl Compounds; Deoxyguanosine; Diabetes Mellitus; Diabetic Nephropathies; Dinoprost; Disease Models, Animal; Hydralazine; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Tetrazoles; Treatment Outcome; Tyrosine | 2009 |
Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: protective effect of taurine.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Hyperhomocysteinemia; Inflammation; Lipid Peroxides; Liver; Male; Malondialdehyde; Methionine; Necrosis; Nitrosation; Oxidative Stress; Rats; Rats, Wistar; Taurine; Tyrosine | 2009 |
16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Bleomycin; Body Weight; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, Animal; Infusions, Subcutaneous; Interleukin-1beta; Lung; Lung Injury; Male; Mice; Peroxidase; Pneumonia; Protective Agents; Pulmonary Edema; Pulmonary Fibrosis; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.
Topics: Animals; Cardiolipins; Cardiomyopathies; Cell Respiration; Diabetes Mellitus, Experimental; Electron Transport Chain Complex Proteins; Female; Lipid Peroxidation; Mice; Mitochondria, Heart; Myocardial Contraction; Myocardium; Oxidative Stress; Phenotype; Superoxides; Tyrosine; Ventricular Function, Left; Ventricular Pressure | 2009 |
[Impairment of pancreatic islet beta cell function induced by intermittent high glucose through oxidative and endoplasmic reticulum stress: experiment with rat pancreatic islet beta cells].
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Blotting, Western; Cell Line, Tumor; Deoxyguanosine; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Glucose; Insulin; Insulin-Secreting Cells; Oxidative Stress; Peroxiredoxins; Radioimmunoassay; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2008 |
Methylmalonate-induced seizures are attenuated in inducible nitric oxide synthase knockout mice.
Topics: Animals; Brain; Brain Mapping; Electroencephalography; Female; Male; Methylmalonic Acid; Mice; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Seizures; Sodium-Potassium-Exchanging ATPase; Succinate Dehydrogenase; Tyrosine | 2009 |
A rapid and selective mass spectrometric method for the identification of nitrated proteins.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, Liquid; Mass Spectrometry; Milk Proteins; Molecular Sequence Data; Nitrates; Oxidation-Reduction; Peptides; Proteins; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2008 |
Correlative transmission microscopy: cytochemical localization and immunocytochemical localization in studies of oxidative and nitrosative stress.
Topics: Animals; Hydrogen Peroxide; Immunohistochemistry; Microscopy; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxidative Stress; Reactive Nitrogen Species; Superoxides; Tissue and Organ Procurement; Tissue Fixation; Tyrosine | 2008 |
MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Creatinine; Gene Expression; Kidney; Kidney Diseases; Kidney Function Tests; Lipid Peroxidation; Male; Metalloporphyrins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta.
Topics: Adult; Biomarkers; Blotting, Western; Body Mass Index; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Obesity; Oxidative Stress; Placenta; Pregnancy; Protein Carbonylation; Reactive Nitrogen Species; Superoxide Dismutase; Thinness; Tyrosine; Young Adult | 2009 |
Homocysteine decreases platelet NO level via protein kinase C activation.
Topics: Analysis of Variance; Blood Platelets; Citrulline; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Homocysteine; Humans; Microscopy, Fluorescence; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Kinase C; Superoxides; Tyrosine | 2009 |
Inflammatory mediators and blood brain barrier disruption in fatal brain edema of diabetic ketoacidosis.
Topics: Adolescent; Albumins; Blood Vessels; Blood-Brain Barrier; Brain; Brain Edema; Cell Adhesion Molecules; Chemokine CCL2; Claudin-5; Diabetic Ketoacidosis; Female; Humans; Immunohistochemistry; Membrane Proteins; Microglia; Neurons; NF-kappa B; Occludin; Phosphoproteins; Receptors, Cell Surface; Tyrosine; Zonula Occludens-1 Protein | 2009 |
Inflammatory and redox status of ponies with a history of pasture-associated laminitis.
Topics: Aging; Animal Husbandry; Animals; Cytokines; Female; Foot Diseases; Hoof and Claw; Horse Diseases; Horses; Inflammation; Oxidation-Reduction; Risk Factors; Superoxide Dismutase; Tyrosine | 2009 |
Estrogen replacement suppresses pressor response and oxidative stress induced by cage-switch stress in ovariectomized rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Estrogen Replacement Therapy; Estrogens; Female; Housing, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Oxidative Stress; Placebos; Random Allocation; Rats; Rats, Wistar; Stress, Psychological; Tyrosine | 2008 |
Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa.
Topics: Antibodies, Bacterial; Atrophy; Biomarkers; Gastric Mucosa; Gastritis, Atrophic; Gastroscopy; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-8; Nitric Oxide; Nitric Oxide Synthase Type II; Prospective Studies; Proteins; RNA, Messenger; Severity of Illness Index; Tyrosine | 2008 |
Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
Topics: Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Humans; Mice; Molsidomine; Nitrogen Dioxide; Peroxynitrous Acid; Protein Structure, Quaternary; Protein Structure, Tertiary; Pulmonary Surfactant-Associated Protein D; Rats; Recombinant Proteins; Tandem Mass Spectrometry; Tyrosine | 2009 |
Impaired mitochondrial respiration and protein nitration in the rat hippocampus after acute inhalation of combustion smoke.
Topics: Acute Disease; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Hippocampus; Male; Mass Spectrometry; Mitochondria; Nerve Tissue Proteins; Nitrates; Oxygen Consumption; Proteomics; Rats; Rats, Sprague-Dawley; Smoke Inhalation Injury; Subcellular Fractions; Succinates; Tyrosine | 2009 |
Germinated Buckwheat extract decreases blood pressure and nitrotyrosine immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Chromatography, High Pressure Liquid; Endothelial Cells; Fagopyrum; Molecular Structure; Oxidative Stress; Plant Extracts; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rutin; Tyrosine | 2009 |
Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Inflammation; Nitric Oxide Synthase Type II; Osteoarthritis; Rats; Severity of Illness Index; Tyrosine | 2009 |
Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target.
Topics: Animals; Blotting, Western; Electron Transport Complex I; Electrophoresis, Gel, Two-Dimensional; Mice; Mitochondria, Heart; Mitochondrial Proteins; Myocardial Reperfusion Injury; Nitrates; Proteomics; Tandem Mass Spectrometry; Tyrosine | 2009 |
Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia.
Topics: Animals; Animals, Newborn; Cell Death; Cell Proliferation; Glutathione Peroxidase; Hyperoxia; In Situ Nick-End Labeling; Inhalation Exposure; Mice; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2; Oxidative Stress; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein C; Survival Analysis; Tyrosine | 2009 |
A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice.
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Tocopherol; Inflammation; Leukotriene B4; Male; Mice; Tyrosine | 2009 |
Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: mitochondrial impairment, increased 3-nitrotyrosine and alpha-synuclein, but decreased D2 receptor contents.
Topics: alpha-Synuclein; Animals; Caspase 3; Dietary Supplements; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Energy Metabolism; Free Radical Scavengers; Glutathione Transferase; Indicators and Reagents; Mitochondria; Neostriatum; Oxidation-Reduction; Rats; Receptors, Dopamine D2; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine; Vitamin A; Vitamins | 2009 |
NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart.
Topics: Acetophenones; Acetylcholine; Aldehydes; Animals; Antioxidants; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Heart Failure; Hemodynamics; Male; NADPH Oxidases; Oxidative Stress; RNA, Messenger; Superoxides; Tyrosine; Up-Regulation; Vasodilation; Vasodilator Agents | 2009 |
Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet function.
Topics: Adult; Aged; Antioxidants; Catalase; Cell Culture Techniques; Cells, Cultured; Esters; Female; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Humans; Hypoglycemic Agents; Islets of Langerhans; Male; Middle Aged; Molecular Weight; Oxidative Stress; Piperidines; Superoxide Dismutase; Tyrosine | 2008 |
Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Brain; Electron Transport Chain Complex Proteins; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Female; GA-Binding Protein Transcription Factor; Gene Expression Regulation; Humans; Male; Middle Aged; Multiple Sclerosis; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2009 |
Plasma 3-nitrotyrosine, urinary 8-isoprostane and 8-OHdG among healthy Japanese people.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Aged; Biomarkers; Deoxyguanosine; Dinoprost; Female; Humans; Japan; Life Style; Male; Oxidative Stress; Reactive Oxygen Species; Risk Factors; Tyrosine; Young Adult | 2009 |
Effect of bicyclol on cisplatin-induced hepatotoxicity in the hepatocarcinoma 22 tumour-bearing mice.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cisplatin; Drug Interactions; Gene Expression Regulation; L-Lactate Dehydrogenase; Liver; Liver Diseases; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Transaminases; Tyrosine | 2009 |
B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Carotid Arteries; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Femoral Artery; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Superoxides; Tyrosine; Vascular Resistance; Vasodilation; Vasodilator Agents | 2009 |
Nitric oxide platelet production in spontaneous miscarriage in the first trimester.
Topics: Abortion, Spontaneous; Adult; Blood Platelets; Case-Control Studies; Female; Humans; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Pregnancy; Pregnancy Trimester, First; Retrospective Studies; Tyrosine | 2010 |
Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery.
Topics: Adipose Tissue; Adult; Bariatric Surgery; Body Mass Index; Body Weight; Female; Humans; Intra-Abdominal Fat; Lipid Peroxides; Lipoproteins, HDL; Longitudinal Studies; Middle Aged; Obesity; Oxidative Stress; Predictive Value of Tests; Reactive Oxygen Species; Subcutaneous Fat; Tyrosine; Weight Loss | 2009 |
Oxidative/nitrative modifications of plasma proteins and thiols from patients with schizophrenia.
Topics: Adult; Biomarkers; Blood Proteins; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzyme-Linked Immunosorbent Assay; Female; Glutathione; Homocysteine; Humans; Male; Oxidative Stress; Schizophrenia; Tyrosine | 2009 |
Quantum chemical investigation of nitrotyrosine (3-nitro-L-tyrosine) and 8-nitroguanine.
Topics: Guanine; Models, Molecular; Quantum Theory; Tyrosine; Vibration | 2010 |
Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion.
Topics: Animals; Aquaporin 4; Atrasentan; Blood-Brain Barrier; Brain; Capillary Permeability; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Immunoglobulins; Infarction, Middle Cerebral Artery; Matrix Metalloproteinase 2; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Transgenic; NADPH Oxidase 2; NADPH Oxidases; Occludin; Oxidative Stress; Promoter Regions, Genetic; Pyrrolidines; Receptor, Endothelin A; Receptor, TIE-1; Superoxides; Tyrosine; Water | 2009 |
Modifications of blood platelet proteins of patients with schizophrenia.
Topics: Adult; Blood Platelets; Blood Proteins; Female; Humans; Male; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Reactive Nitrogen Species; Reactive Oxygen Species; Schizophrenia; Surveys and Questionnaires; Tyrosine | 2009 |
Quantitative identification of protein nitration sites.
Topics: Acetylation; Amino Acid Sequence; Amino Acids; Animals; Blotting, Western; Cattle; Electrophoresis, Polyacrylamide Gel; Escherichia coli Proteins; Milk Proteins; Molecular Sequence Data; Myoglobin; Peptides; Proteins; Proteomics; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2009 |
Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine?
Topics: Adult; Area Under Curve; Female; Half-Life; Humans; Male; Migraine Disorders; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Sulfones; Tyrosine | 2009 |
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Case-Control Studies; Cell Line; Cell Line, Tumor; Frontal Lobe; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron; Models, Molecular; Neuroblastoma; Neurofibrillary Tangles; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; tau Proteins; Triose-Phosphate Isomerase; Tyrosine | 2009 |
Increased receptor for advanced glycation endproducts immunocontent in the cerebral cortex of vitamin A-treated rats.
Topics: Animals; Blotting, Western; Caspase 8; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Protein Carbonylation; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vitamin A | 2009 |
Role of oxidative stress in elevated blood pressure induced by high free fatty acids.
Topics: Animals; Blood Pressure; Fatty Acids, Nonesterified; Glucose Clamp Technique; Glutathione; Hypertension; In Vitro Techniques; Male; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrosine | 2009 |
Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy.
Topics: Acetylcholine; Animals; Aorta; Blotting, Western; Carbon; Cardiovascular Diseases; Endothelium, Vascular; Immunohistochemistry; Kidney; Kidney Function Tests; Male; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type III; Obesity; Oxidative Stress; Oxides; Phosphorylation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2009 |
Nitrosative stress, protein tyrosine nitration, PARP activation and NAD depletion in the kidneys of rats after single dose of cyclophosphamide.
Topics: Animals; Cyclophosphamide; DNA Damage; Down-Regulation; Enzyme Activation; Immunohistochemistry; Injections, Intraperitoneal; Kidney; Male; NAD; Nitrates; Nitrites; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Nitrogen Species; Superoxide Dismutase; Time Factors; Tyrosine | 2009 |
Lactobacillus fermentum CECT 5716 prevents and reverts intestinal damage on TNBS-induced colitis in mice.
Topics: Animals; Colitis; Colony Count, Microbial; Cytokines; Disease Models, Animal; Eicosanoids; Immunoenzyme Techniques; Intestinal Mucosa; Limosilactobacillus fermentum; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; Peroxidase; Probiotics; Trinitrobenzenesulfonic Acid; Tyrosine | 2009 |
Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling.
Topics: Animals; Calcimycin; Capillaries; Dose-Response Relationship, Drug; Endothelium, Vascular; Inhalation Exposure; Lung; Male; Nanoparticles; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Particle Size; Rats; Rats, Sprague-Dawley; Signal Transduction; Titanium; Tyrosine; Vasodilation | 2009 |
Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage.
Topics: Actin Cytoskeleton; Animals; Avena; Colon; Colonic Diseases; Cytoskeleton; Edible Grain; Ethanol; Intestinal Mucosa; Male; Models, Biological; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Permeability; Peroxidase; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Tight Junctions; Tyrosine | 2009 |
Protective effects of a coumarin derivative in diabetic rats.
Topics: Animals; Antigens, CD; Blood-Retinal Barrier; Blotting, Western; Cadherins; Chromonar; Claudin-5; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Injections, Intraperitoneal; Intercellular Adhesion Molecule-1; Male; Membrane Proteins; Nitric Oxide Synthase Type III; Occludin; Phosphoproteins; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2009 |
Determination of nitrotyrosine concentrations in plasma samples of diabetes mellitus patients by four different immunoassays leads to contradictive results and disqualifies the majority of the tests.
Topics: Diabetes Mellitus; Humans; Immunoassay; Tyrosine | 2009 |
Erythropoietin attenuates lung injury in lipopolysaccharide treated rats.
Topics: Animals; Erythropoietin; Lipopolysaccharides; Lung; Lung Injury; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Cell Line; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Free Radical Scavengers; Heart Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Contraction; Myocytes, Cardiac; Necrosis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Superoxides; Tyrosine; Ventricular Function, Left; Ventricular Pressure | 2009 |
Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; Monocytes; Proteomics; Rats; Tyrosine | 2009 |
Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Aorta, Thoracic; Aortic Diseases; Ascorbic Acid; Atherosclerosis; Deoxyguanosine; Endothelium, Vascular; Glutathione; Lysine; Male; Oxidative Stress; Periodontitis; Random Allocation; Rats; Rats, Wistar; Tyrosine; Vitamins | 2009 |
Paracrine purinergic signaling determines lung endothelial nitric oxide production.
Topics: Animals; Calcium Signaling; Cytosol; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microcirculation; Nitric Oxide; Nitric Oxide Synthase Type III; Paracrine Communication; Pulmonary Alveoli; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Tyrosine | 2009 |
Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization.
Topics: Aldehydes; Animals; Apoptosis; Arginase; Biopterins; Cyclosporine; Cytokines; Echocardiography; Gene Expression; Graft Rejection; GTP Cyclohydrolase; Heart Transplantation; Heart Ventricles; Immunosuppressive Agents; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; Pterins; Rats; Rats, Inbred Lew; Rats, Inbred WF; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine | 2009 |
Coagulation and oxidative stress plasmatic levels in a type 2 diabetes population.
Topics: Adult; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Body Mass Index; Diabetes Mellitus, Type 2; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse.
Topics: Administration, Oral; Animals; Antioxidants; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Azoles; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelial Cells; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; I-kappa B Kinase; Isoindoles; JNK Mitogen-Activated Protein Kinases; Macrophages; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NADPH Oxidase 2; NADPH Oxidases; Organoselenium Compounds; Phenotype; Phosphorylation; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A | 2009 |
Increased nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: potential role of protein oxidation in autoimmunity.
Topics: Animals; Autoimmune Diseases; Cells, Cultured; Cytokines; Drug Administration Schedule; Female; Gene Expression Regulation; Kidney; Liver; Mice; Mice, Inbred MRL lpr; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Spleen; Trichloroethylene; Tyrosine | 2009 |
Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism.
Topics: Aldehydes; Aldosterone; Amlodipine; Animals; Calcium; Calcium Channel Blockers; Chronic Disease; Disease Models, Animal; Glutathione Peroxidase; Homeostasis; Hydrogen Peroxide; Hyperaldosteronism; Male; Metallothionein; Mineralocorticoid Receptor Antagonists; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spironolactone; Superoxide Dismutase; Tyrosine; Zinc | 2009 |
Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma.
Topics: Animals; Apoptosis; Disease Models, Animal; Edema; Immunohistochemistry; Inflammation; Male; Mice; Neutrophil Infiltration; Oxidative Stress; Plant Extracts; Poly(ADP-ribose) Polymerases; Spinal Cord Injuries; Tea; Time Factors; Tyrosine | 2009 |
The opposite roles of nNOS in cardiac ischemia-reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice.
Topics: Animals; Apoptosis; Enzyme Inhibitors; Free Radical Scavengers; Ischemic Preconditioning, Myocardial; Lipid Peroxidation; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type I; Ornithine; Oxidative Stress; Reactive Nitrogen Species; Thiobarbituric Acid Reactive Substances; Tyrosine | 2009 |
In vivo amelioration of adriamycin induced oxidative stress in plasma by gamma-glutamylcysteine ethyl ester (GCEE).
Topics: Animals; Antineoplastic Agents; Antioxidants; Dipeptides; Doxorubicin; Male; Mice; Mice, Inbred Strains; Oxidative Stress; Protein Carbonylation; Tyrosine | 2009 |
Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cytochromes c; Disease Models, Animal; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Mutation; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Superoxide Dismutase; Tyrosine; Ubiquitin | 2009 |
Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats.
Topics: Animals; Blood Pressure; Cardiovascular Abnormalities; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Lysine; Male; Mesenteric Artery, Superior; Methoxamine; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Time Factors; Tyrosine | 2009 |
Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.
Topics: Acetylcholine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Benzoates; Blood Vessels; Blotting, Western; Enzyme Activation; Immunoenzyme Techniques; Luminescence; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroprusside; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Telmisartan; Tyrosine; Vasoconstrictor Agents; Vasodilation | 2009 |
Possible impact of impaired double-stranded RNA degradation and nitrosative stress on immuno-inflammatory cascade in type 2 diabetes.
Topics: Adult; Aged; Animals; bcl-2-Associated X Protein; Blood Glucose; Cells, Cultured; DEAD-box RNA Helicases; Diabetes Mellitus, Type 2; Female; Fluorescent Antibody Technique; Humans; Inflammation; Interferon Regulatory Factor-3; Interferon-Induced Helicase, IFIH1; Male; Middle Aged; NF-kappa B; Nitrites; Nucleic Acids; Proto-Oncogene Proteins c-bcl-2; Rats; RNA Stability; RNA, Double-Stranded; Thymus Gland; Tyrosine; Xanthine Oxidase | 2009 |
Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.
Topics: Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hindlimb; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Conduction; Nitric Oxide Synthase Type I; Pain Measurement; Sciatic Nerve; Streptozocin; Tyrosine | 2009 |
Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Diarrhea; Dose-Response Relationship, Drug; Guanidines; HeLa Cells; Humans; Intestinal Mucosa; Intestine, Small; Male; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Radiation Injuries; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Analysis of oxidative stress biomarkers using a simultaneous competitive/non-competitive micromosaic immunoassay.
Topics: Animals; Binding, Competitive; Biomarkers; Catalase; Cattle; Immunoassay; Mice; Microfluidic Analytical Techniques; Oxidative Stress; Sensitivity and Specificity; Superoxide Dismutase; Time Factors; Tyrosine | 2009 |
Analysis of oxidative modification of proteins.
Topics: Isoaspartic Acid; Oxidation-Reduction; Protein Carbonylation; Proteins; Sulfhydryl Compounds; Tyrosine | 2009 |
Maternal adaptation in pregnant hypertensive rats: improvement of vascular and inflammatory variables and oxidative damage in the kidney.
Topics: Adaptation, Physiological; Animals; Blood Pressure; Chemokine CCL2; Cyclooxygenase 2; Female; Heart Rate; Hypertension; I-kappa B Proteins; Kidney; Lipid Peroxidation; Malondialdehyde; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Transcription Factor RelA; Tyrosine | 2009 |
Mechanisms of peroxynitrite-mediated nitration of tyrosine.
Topics: Carbon Dioxide; Carbonates; Hydroxyl Radical; Nitrates; Nitrogen Dioxide; Peroxynitrous Acid; Tyrosine | 2009 |
Detection of 4-hydroxy-2-nonenal- and 3-nitrotyrosine-modified proteins using a proteomics approach.
Topics: Aldehydes; Electrophoresis, Gel, Two-Dimensional; Humans; Isoelectric Focusing; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Proteins; Proteomics; Tyrosine | 2009 |
Methylamine dichloramine may play a role in the process of colorectal disease through architectural and oxidative changes in crypts in mice.
Topics: Aldehydes; Animals; Chloramines; Colon; Colonic Neoplasms; Hemoglobins; Hemolysis; Hydrogen Peroxide; Hypochlorous Acid; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Neutrophil Activation; Oxidation-Reduction; Sheep; Tyrosine | 2009 |
Protein oxidation under extremely low frequency electric field in guinea pigs. Effect of N-acetyl-L-cysteine treatment.
Topics: Acetylcysteine; Analysis of Variance; Animals; Electromagnetic Fields; Free Radical Scavengers; Guinea Pigs; Hydroxyproline; Liver; Male; Oxidation-Reduction; Protein Carbonylation; Proteins; Radiation-Protective Agents; Random Allocation; Tyrosine | 2009 |
Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion.
Topics: Amidines; Animals; Antioxidants; Benzylamines; Enzyme Inhibitors; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Intestinal Mucosa; Intestines; Kidney; Liver; Lung; Male; Malondialdehyde; Melatonin; Mesenteric Vascular Occlusion; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Survival Rate; Tyrosine | 2009 |
Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis.
Topics: Air Pollutants; Animals; Aorta; Atherosclerosis; Blood Pressure; DNA Damage; DNA, Mitochondrial; Heart Rate; Lung Diseases; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Diseases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidants; Oxidative Stress; Ozone; Superoxide Dismutase; Tyrosine | 2009 |
Peroxynitrite induces gene expression in intervertebral disc cells.
Topics: Active Transport, Cell Nucleus; Adolescent; Adult; Cell Nucleus; Cells, Cultured; Female; Gene Expression; Humans; Immunohistochemistry; Interleukin-10; Interleukin-1beta; Interleukin-6; Interleukin-8; Intervertebral Disc; Intervertebral Disc Displacement; Male; Middle Aged; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.
Topics: Animals; Arachidonic Acid; Arterioles; C-Reactive Protein; Cell Separation; Cytochrome P-450 Enzyme System; Enzyme Activation; Epoprostenol; Immunohistochemistry; Intramolecular Oxidoreductases; Nitric Oxide; Nitroprusside; Peroxynitrous Acid; Serotonin; Sus scrofa; Tyrosine; Vasodilation; Vasomotor System | 2009 |
Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice.
Topics: Aging; Air; Animals; Animals, Newborn; Body Weight; Bronchoalveolar Lavage Fluid; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Gene Deletion; Hyperoxia; Mice; NADPH Oxidases; Oxygen; Pneumonia; Protein Transport; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein C; Survival Analysis; Tyrosine | 2009 |
Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats.
Topics: Animals; Antioxidants; Arginase; Basilar Artery; Brain; Constriction, Pathologic; Free Radicals; Immunohistochemistry; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Subarachnoid Hemorrhage; Superoxide Dismutase; Tyrosine; Vasospasm, Intracranial | 2009 |
PPAR-alpha modulate the anti-inflammatory effect of glucocorticoids in the secondary damage in experimental spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Dexamethasone; Disease Models, Animal; Inflammation Mediators; Interleukin-1beta; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide Synthase Type II; PPAR alpha; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.
Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascular; In Vitro Techniques; Male; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Exertion; Superoxide Dismutase; Tyrosine; Vasodilation | 2009 |
Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cytokines; Disease Models, Animal; Immunoenzyme Techniques; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mice; Motor Activity; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Tyrosine | 2009 |
Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer.
Topics: Acute Disease; Animals; Annexin A5; Blotting, Western; Caspases; Cell Death; Cell Line; Cytoprotection; Drug Delivery Systems; Enzyme Activation; Fluoresceins; Free Radical Scavengers; Glycolates; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lactic Acid; Neurons; Nitric Oxide; Peroxynitrous Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Signal Transduction; Spinal Cord Injuries; Stem Cells; Tyrosine | 2009 |
Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury.
Topics: Aldehydes; Animals; Female; Immunohistochemistry; Lipid Peroxidation; Neurons; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae; Time Factors; Tyrosine | 2009 |
Role of postnatal dietary sodium in prenatally programmed hypertension.
Topics: Animals; Blood Pressure; Diet, Protein-Restricted; Female; Hypertension; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Nephrosclerosis; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Sprague-Dawley; Sodium; Tyrosine | 2009 |
Acrylamide decreased dopamine levels and increased 3-nitrotyrosine (3-NT) levels in PC 12 cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acrylamide; Animals; Chromatography, High Pressure Liquid; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrochemical Techniques; Homovanillic Acid; Methamphetamine; Neurons; PC12 Cells; Rats; Time Factors; Tyrosine | 2009 |
3-Nitrotyrosine inhibits fibroblast-mediated collagen gel contraction and chemotaxis.
Topics: Cell Line; Chemotaxis; Collagen; Fibroblasts; Fibronectins; Gels; Humans; Inflammation; Lung; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Transforming Growth Factor beta; Tyrosine; Vascular Endothelial Growth Factor A | 2009 |
Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antioxidants; Apoptosis; Collagen; Disease Models, Animal; Disease Progression; Fibrosis; Glucosephosphate Dehydrogenase; HSP47 Heat-Shock Proteins; Hydrogen Peroxide; Ischemia; Kidney; Lipid Peroxidation; Male; Metalloporphyrins; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Oxidative Stress; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Reperfusion Injury; S100 Calcium-Binding Protein A4; S100 Proteins; Superoxide Dismutase; Time Factors; Tyrosine; Vitamin E | 2009 |
Glycaemic status in relation to oxidative stress and inflammation in well-controlled type 2 diabetes subjects.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Biomarkers; Blood Glucose; Body Mass Index; C-Reactive Protein; Deoxyguanosine; Diabetes Mellitus, Type 2; Dinoprost; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Insulin; Interleukin-6; Lipids; Male; Malondialdehyde; Middle Aged; Obesity; Oxidative Stress; Probability; Statistics, Nonparametric; Tyrosine; Waist Circumference | 2009 |
Oxidative stress related changes in the brain of hypercholesterolemic rabbits.
Topics: Animals; Brain; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Proteasome Endopeptidase Complex; Protein Carbonylation; Rabbits; Tyrosine; Vitamin E | 2008 |
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.
Topics: Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Formazans; Humans; Indoles; Lipoproteins, LDL; Molecular Structure; NADPH Oxidases; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Pyrans; Reactive Oxygen Species; Tetrazolium Salts; Time Factors; Tyrosine; Umbilical Veins; Xylariales | 2009 |
The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Catalase; Cell Survival; Cytoprotection; Fatty Acids; Free Radical Scavengers; Gene Expression Regulation; Glucokinase; Glucose Transporter Type 2; Glutathione Peroxidase; Humans; Insulin; Islets of Langerhans; Molecular Weight; Oxidative Stress; Peptides; Piperidines; RNA, Messenger; Superoxide Dismutase; Tyrosine | 2009 |
Exhaled breath condensate biomarkers in asbestos-related lung disorders.
Topics: Aged; Asbestos; Asbestosis; Biomarkers; Dinoprost; Forced Expiratory Volume; Humans; Lung Diseases; Male; Nitric Oxide; Oxidative Stress; Prognosis; Tyrosine | 2009 |
Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia.
Topics: Adult; Female; Gene Expression; Humans; Kidney; Membrane Proteins; Podocytes; Pre-Eclampsia; Pregnancy; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Retrospective Studies; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2009 |
Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine.
Topics: Animals; Antigens; Cell Adhesion Molecules; Cisplatin; Gentamicins; Immunohistochemistry; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Nitric Oxide Synthase Type II; Photomicrography; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tyrosine; Valproic Acid | 2009 |
Vitamin A supplementation at pharmacological doses induces nitrosative stress on the hypothalamus of adult Wistar rats.
Topics: Administration, Oral; alpha-Synuclein; Animals; Brain; Caspase 3; Electron Transport Chain Complex Proteins; Hypothalamus; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Receptors, Dopamine D2; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vitamin A | 2009 |
Nitroavidin as a ligand for the surface capture and release of biotinylated proteins.
Topics: Animals; Avidin; Azo Compounds; Biotin; Biotinylation; Chickens; Immobilized Proteins; Ligands; Nitro Compounds; Ovum; Peptides; Protein Binding; Proteins; Surface Plasmon Resonance; Tetranitromethane; Tyrosine | 2008 |
Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Fatty Acids, Unsaturated; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Kidney; Linoleic Acid; Mice; Mitochondria; Models, Biological; Peroxynitrous Acid; Tyrosine | 2009 |
Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Glutathione; Glutathione Disulfide; Hyperglycemia; Male; Mice; Mice, Inbred Strains; Microcirculation; Myocardium; Oxidants; Oxidation-Reduction; Specific Pathogen-Free Organisms; Stroke Volume; Tyrosine; Vascular Endothelial Growth Factor A; Ventricular Function, Left | 2009 |
3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder.
Topics: Adult; Antioxidants; Bipolar Disorder; Case-Control Studies; Female; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Humans; Male; Oxidative Stress; Protein Carbonylation; Psychotropic Drugs; Tyrosine | 2009 |
Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation.
Topics: Analysis of Variance; Animals; Carotid Artery, Common; Disease Models, Animal; Dogs; Female; Gene Expression Regulation; Hemodynamics; Intracranial Aneurysm; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Stress, Mechanical; Time Factors; Tyrosine | 2009 |
Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Alanine Transaminase; Animals; Catechols; Chemical and Drug Induced Liver Injury; Deoxyguanosine; Diet; DNA Damage; Glutathione; Immunohistochemistry; Inflammation; Liver; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Oxidation-Reduction; Time Factors; Transaminases; Tyrosine | 2009 |
Aged garlic extract delays the appearance of infarct area in a cerebral ischemia model, an effect likely conditioned by the cellular antioxidant systems.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Garlic; Glutathione Peroxidase; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2010 |
Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air).
Topics: Animals; Animals, Newborn; Apoferritins; Carbon Monoxide Poisoning; Cerebellum; Disease Models, Animal; Embryo, Mammalian; Female; Heme Oxygenase-1; Male; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
Modulation of SERCA in the chronic phase of adjuvant arthritis as a possible adaptation mechanism of redox imbalance.
Topics: Adaptation, Physiological; Animals; Arthritis, Experimental; Calcium; Calsequestrin; Chronic Disease; Kinetics; Lipid Peroxidation; Muscle, Skeletal; Mycobacterium; Oxidation-Reduction; Oxidative Stress; Phosphatidic Acids; Protein Carbonylation; Protein Conformation; Rats; Rats, Inbred Lew; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Up-Regulation | 2009 |
Protein nitration during defense response in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Mass Spectrometry; Nitrates; Nitrosation; Plant Diseases; Proteomics; Tyrosine | 2009 |
Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; CD40 Antigens; Disease Models, Animal; Female; Humans; Immunoprecipitation; Male; Matrix Metalloproteinase 9; Maze Learning; Mice; Mice, Transgenic; Minocycline; Nerve Growth Factor; Nerve Growth Factors; Nitric Oxide Synthase Type II; Peptide Fragments; Peroxynitrous Acid; Protein Precursors; Rats; Rats, Inbred F344; Reaction Time; Tyrosine; Up-Regulation | 2009 |
Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Disease Models, Animal; Ethanolamines; Hypertension, Renal; NADPH Oxidases; Nebivolol; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reactive Oxygen Species; Renin; Renin-Angiotensin System; Tyrosine | 2009 |
Aging impairs flow-induced dilation in coronary arterioles: role of NO and H(2)O(2).
Topics: Aging; Animals; Antioxidants; Arterioles; Catalase; Coronary Circulation; Cyclic N-Oxides; Deferoxamine; Hydrogen Peroxide; Male; Microscopy, Fluorescence; Nitric Oxide; Rats; Rats, Inbred F344; Reactive Oxygen Species; RNA, Messenger; Siderophores; Spin Labels; Superoxide Dismutase; Tyrosine; Vasodilation | 2009 |
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cerebral Arteries; Chemokine CCL2; Eplerenone; Female; Gene Expression; Hypertension, Renal; Immunohistochemistry; Intracranial Aneurysm; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Ovariectomy; Oxidative Stress; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spironolactone; Tyrosine | 2009 |
Expression of heat shock proteins and nitrotyrosine in small arteries from patients with coronary heart disease.
Topics: Adult; Aged; Arteries; Case-Control Studies; Chaperonin 60; Coronary Artery Disease; Female; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Male; Middle Aged; Molecular Chaperones; Oxidative Stress; Subcutaneous Fat; Tyrosine | 2009 |
Mild cerebral hypoxia-ischemia produces a sub-acute transient inflammatory response that is less selective and prolonged after a substantial insult.
Topics: Animals; Brain; Cell Death; Glial Fibrillary Acidic Protein; Hypoxia-Ischemia, Brain; Inflammation; Myelin Basic Protein; Random Allocation; Rats; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Peroxynitrite mediates glomerular lesion of diabetic rat via JAK/STAT signaling pathway.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibronectins; Immunohistochemistry; Janus Kinase 2; Kidney Glomerulus; Male; Microscopy, Electron, Transmission; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Transforming Growth Factor beta; Tyrosine; Uric Acid | 2009 |
Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Drug Synergism; Inflammation Mediators; Male; Memory Disorders; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Peptide Fragments; RNA, Messenger; Silybin; Silymarin; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2009 |
[Laboratory evaluation of endothelial function in term neonatal infants born to mothers with gestosis].
Topics: Case-Control Studies; Endothelial Cells; Endothelium, Vascular; Female; Homocysteine; Humans; Infant, Newborn; Nitric Oxide; Oxidative Stress; Pre-Eclampsia; Pregnancy; Term Birth; Tyrosine | 2009 |
Detection of 3-nitrotyrosine-modified human leukocyte antigen-G in biological fluids.
Topics: Body Fluids; Enzyme-Linked Immunosorbent Assay; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Nitrates; Nitric Oxide; Nitrites; Protein Multimerization; Protein Processing, Post-Translational; Tyrosine | 2009 |
Peroxynitrite and heme protein--mediated nitrative/oxidative modification of human plasma protein: the role of free radical scavenging vs. complex forming.
Topics: Antioxidants; Blood Proteins; Chromans; Deferoxamine; Free Radical Scavengers; Glutathione; Hemeproteins; Humans; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2009 |
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Cell Line, Transformed; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Gene Expression Regulation; Herbicides; Hydrogen Peroxide; Mesencephalon; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Paraquat; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Tyrosine; Vitamin E | 2009 |
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.
Topics: Animals; Arterioles; Biomarkers; Chemokine CCL2; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; I-kappa B Proteins; Inflammation Mediators; Macrophages; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Receptors, Leptin; Serine; Signal Transduction; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2009 |
Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats.
Topics: Animals; Galactosamine; Humans; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Oxidative Stress; Peroxynitrous Acid; Quercetin; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins.
Topics: Adolescent; Adult; Aged; Brachial Artery; Endothelial Cells; Female; Fluorescent Antibody Technique; Humans; Linear Models; Male; Microscopy, Fluorescence; Middle Aged; Nitric Oxide Synthase Type III; Phosphorylation; Proteins; Serine; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Upper Extremity; Veins; Xanthine Oxidase; Young Adult | 2010 |
Immunohistochemical analysis of selected molecular markers in esophagus precancerous, adenocarcinoma and squamous cell carcinoma in Iranian subjects.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Barrett Esophagus; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 2; Disease Progression; Esophageal Neoplasms; Esophagus; Female; Gastroesophageal Reflux; Glutathione S-Transferase pi; Humans; Immunohistochemistry; Iran; Male; Middle Aged; Precancerous Conditions; Tumor Suppressor Protein p53; Tyrosine; Young Adult | 2009 |
Thalidomide suppresses sclerosing encapsulating peritonitis in a rat experimental model.
Topics: Animals; Anti-Infective Agents; Blotting, Western; Chlorhexidine; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation; I-kappa B Proteins; Immunohistochemistry; Immunosuppressive Agents; NF-kappa B; Nitric Oxide Synthase Type II; Peritonitis; Peroxidase; Poly Adenosine Diphosphate Ribose; Rats; Thalidomide; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A | 2009 |
The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.
Topics: Analysis of Variance; Androstanes; Animals; Apoptosis; Benzimidazoles; Body Temperature; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Corpus Striatum; Dose-Response Relationship, Drug; Drug Combinations; Electrochemistry; Immunotoxins; In Situ Nick-End Labeling; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Substance P; Tyrosine | 2009 |
[Investigation to the levels of 3-nitrotyrosine and their correlation factors in type 2 diabetic patients].
Topics: Aged; Case-Control Studies; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Male; Middle Aged; Regression Analysis; Serum Albumin; Tyrosine | 2009 |
In vivo protein tyrosine nitration in S. cerevisiae: identification of tyrosine-nitrated proteins in mitochondria.
Topics: Mitochondria; Mitochondrial Proteins; Nitrates; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine | 2009 |
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Lewy Bodies; Mass Spectrometry; Models, Biological; Monoamine Oxidase; Nitrates; Oxidative Stress; Parkinson Disease; PC12 Cells; Rats; Tyrosine | 2009 |
Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Dietary Carbohydrates; Dietary Fats; Dioxoles; Endothelium, Vascular; Gene Expression Regulation; Hypertension, Renovascular; Lignans; Lipids; Male; Malondialdehyde; NADPH Oxidases; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Sucrose; Tyrosine | 2009 |
Lipoprotein lipase is nitrated in vivo after lipopolysaccharide challenge.
Topics: Animals; Cattle; Endotoxemia; Hypertriglyceridemia; Lipopolysaccharides; Lipoprotein Lipase; Male; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tyrosine | 2009 |
Run for your life: exercise, oxidative stress and the ageing endothelium.
Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascular; Male; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Exertion; Superoxide Dismutase; Tyrosine; Vasodilation | 2009 |
Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?
Topics: Acute Disease; Adult; Altitude Sickness; Biomarkers; Blood-Brain Barrier; Brain; Free Radicals; Headache; Health Surveys; Humans; Hypoxia; Male; Nerve Growth Factors; Oxidative Stress; Oxygen; Phosphopyruvate Hydratase; Regional Blood Flow; Retrospective Studies; Risk Factors; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine | 2009 |
Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite.
Topics: Animals; Biomarkers; Cholesterol, Dietary; Disease Models, Animal; Hyperlipidemias; Male; Metalloporphyrins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Signal Transduction; Stress, Physiological; Tyrosine | 2009 |
In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography.
Topics: Amino Acid Sequence; Animals; Blood Proteins; Cattle; Cell Extracts; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Disease Models, Animal; Humans; Jurkat Cells; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidation-Reduction; Peptides; Proteome; Proteomics; Salmonella; Serum Albumin, Bovine; Shock, Septic; Tetranitromethane; Thiosulfates; Tyrosine | 2009 |
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats.
Topics: Actins; Air; Animals; Animals, Newborn; Blood Gas Analysis; Blood Vessels; Carbon Dioxide; Elastin; Fluorescent Antibody Technique; Heart Rate; Hypercapnia; Lung; Lung Injury; Neutrophils; Organ Size; Peroxidase; Rats; Subcellular Fractions; Tyrosine; von Willebrand Factor | 2009 |
Role of neutrophils in arginine-asymmetric dimethylarginine pathway subsequent to endotoxemia.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Liver; Male; Neutrophils; Peroxidase; Tyrosine | 2009 |
A physiologically relevant atherogenic diet causes severe endothelial dysfunction within 4 weeks in rabbit.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aortic Diseases; Cholesterol; Cholesterol, Dietary; Diet, Atherogenic; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Male; Methionine; Nitric Oxide Synthase Type III; Rabbits; Severity of Illness Index; Time Factors; Tyrosine; Vasodilator Agents | 2009 |
Induction of NOS and nitrotyrosine expression in the rat striatum following experimental hepatic encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Enzyme Induction; Glial Fibrillary Acidic Protein; Hepatic Encephalopathy; Immunohistochemistry; Male; Neostriatum; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
eNOS uncoupling and endothelial dysfunction in aged vessels.
Topics: Acetylcholine; Age Factors; Aging; Alcohol Oxidoreductases; Animals; Biopterins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Enzyme Stability; GTP Cyclohydrolase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Multimerization; Pterins; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2009 |
Nitrosative stress and glutathione redox system in four different tissues of alloxan-induced hyperglycemic animals.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hyperglycemia; Kidney; Male; Myocardium; Oxidation-Reduction; Pancreas, Exocrine; Rabbits; Testis; Tyrosine | 2009 |
Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN.
Topics: Animals; Aortic Aneurysm, Abdominal; Basigin; Disease Progression; Down-Regulation; Endothelium, Vascular; Enzyme Induction; Extracellular Space; Humans; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Tyrosine | 2009 |
Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation.
Topics: Albuminuria; Aldehydes; Animals; Blotting, Western; Chemokine CCL2; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Intercellular Adhesion Molecule-1; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Nephritis; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Serpin E2; Serpins; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Superoxide signaling in pain is independent of nitric oxide signaling.
Topics: Animals; Antimycin A; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuralgia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain Measurement; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Spin Labels; Superoxides; Tyrosine | 2009 |
Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice.
Topics: Acute Lung Injury; Animals; Animals, Newborn; Arachidonate 5-Lipoxygenase; Coenzyme A; Cyclooxygenase 2; Disease Models, Animal; Glutathione Disulfide; Hydroxyeicosatetraenoic Acids; Hyperoxia; Liver; Lung; Mice; Mice, Inbred C3H; Oxidative Stress; Prostaglandins; Time Factors; Tyrosine | 2010 |
In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species.
Topics: Aldehydes; Animals; Antioxidants; Benzene; Blotting, Western; Catalase; Cell Proliferation; Cells, Cultured; Colony-Forming Units Assay; Environmental Pollutants; Female; Fetal Stem Cells; Flow Cytometry; Gestational Age; Glutathione Disulfide; Hematopoietic Stem Cells; I-kappa B Proteins; Liver; Maternal Exposure; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Polyethylene Glycols; Pregnancy; Proto-Oncogene Proteins c-kit; Reactive Oxygen Species; Time Factors; Tyrosine | 2010 |
Remarkable increase in 3-nitrotyrosine in the cerebrospinal fluid in patients with lacunar stroke.
Topics: Aged; Brain Infarction; Cell Count; Female; Humans; Male; Middle Aged; Severity of Illness Index; Statistics, Nonparametric; Tyrosine | 2009 |
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Catechin; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Glutathione; Hyperoxia; Hypoxia; Ischemia; Lipid Peroxidation; Metalloporphyrins; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Protective Agents; Retinal Neovascularization; Retinal Vessels; Tyrosine | 2010 |
Selective vulnerability of brain regions to oxidative stress in a non-coma model of insulin-induced hypoglycemia.
Topics: Animals; Biomarkers; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Electroencephalography; Hippocampus; Hypoglycemia; Hypoglycemic Agents; Immunohistochemistry; Insulin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Time Factors; Tyrosine | 2010 |
PD98059, a specific MAP kinase inhibitor, attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice.
Topics: Acute Disease; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Adhesion Molecules; Cytokines; Fas Ligand Protein; Flavonoids; I-kappa B Proteins; Inflammation Mediators; Male; Mice; Mitogen-Activated Protein Kinases; Multiple Organ Failure; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peritonitis; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Systemic Inflammatory Response Syndrome; Time Factors; Transcription Factor RelA; Tyrosine; Zymosan | 2010 |
DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antioxidants; Biomarkers, Tumor; Carcinoma; Cell Nucleus; Cytoplasm; DNA Adducts; Female; Guanine; Humans; Immunohistochemistry; Neoplasm Staging; Ovarian Neoplasms; Oxidative Stress; Prognosis; Survival Analysis; Tyrosine | 2009 |
Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: roles of endothelial nitric oxide synthase and endothelial progenitor cells.
Topics: Animals; Blood Glucose; Body Weight; Chemotaxis; Collateral Circulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Endothelial Cells; Hindlimb; Ischemia; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Oxidative Stress; Receptors, Leptin; Recovery of Function; Regional Blood Flow; Stem Cells; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A | 2009 |
Modulation of nitrosative/oxidative stress in the lung of hyperglycemic rabbits by two antidiabetics, pioglitazone and repaglinide.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Catalase; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Hyperglycemia; Hypoglycemic Agents; Lipid Peroxidation; Lung; Male; Oxidative Stress; Pioglitazone; Piperidines; Rabbits; Reactive Nitrogen Species; Superoxide Dismutase; Thiazolidinediones; Tyrosine | 2009 |
[Effects of parabolic flight on redox status in SH-SY5Y cells].
Topics: Animals; Antioxidants; Cell Line, Tumor; Humans; Hypogravity; Nitric Oxide Synthase Type II; Oxidative Stress; PC12 Cells; Rats; Space Flight; Thioredoxin-Disulfide Reductase; Thioredoxins; Transfection; Tyrosine | 2009 |
The pathogenic role of the canonical Wnt pathway in age-related macular degeneration.
Topics: Active Transport, Cell Nucleus; Adenoviridae; Animals; beta Catenin; Cell Line; Culture Media, Conditioned; Humans; Injections, Intraocular; Macular Degeneration; Mice; Oxidative Stress; Rats; Rats, Inbred BN; Reactive Oxygen Species; Retinal Pigment Epithelium; Retinitis; Signal Transduction; Transfection; Tyrosine; Up-Regulation; Vitreous Body; Wnt Proteins; Wnt3 Protein; Wnt3A Protein | 2010 |
The amyloid-beta25-35 injection into the CA1 region of the neonatal rat hippocampus impairs the long-term memory because of an increase of nitric oxide.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; CA1 Region, Hippocampal; Glial Fibrillary Acidic Protein; Immunohistochemistry; Injections, Intraventricular; Maze Learning; Memory; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Rats; Rats, Wistar; Spatial Behavior; Tyrosine | 2010 |
Aggravation of cold-restraint stress-induced gastric lesions in adjuvant arthritic rats: pathogenic role of inducible and endothelial nitric oxide.
Topics: Animals; Arthritis, Experimental; Blotting, Western; Cold Temperature; Enzyme Inhibitors; Gastric Mucosa; Glutathione; Guanidines; Immunohistochemistry; Isoenzymes; Male; Mycobacterium tuberculosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Tyrosine | 2009 |
Neuroprotective effects of tempol on retinal ganglion cells in a partial optic nerve crush rat model with and without iron load.
Topics: Animals; Antioxidants; Cell Count; Cell Survival; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Hematinics; Immunoenzyme Techniques; Iron Overload; Iron-Dextran Complex; Neuroprotective Agents; Optic Nerve Injuries; Oxidative Stress; Rats; Rats, Inbred BN; Retinal Degeneration; Retinal Ganglion Cells; Spin Labels; Tyrosine | 2010 |
Upregulation of intracellular antioxidant enzymes in brain and heart during estivation in the African lungfish Protopterus dolloi.
Topics: Aldehydes; Animals; Biocatalysis; Brain; Catalase; Estivation; Fasting; Fishes; Glutathione Peroxidase; Glutathione Reductase; Myocardium; Oxidoreductases; Potassium Cyanide; Protein Carbonylation; Proteins; Superoxide Dismutase; Tyrosine; Up-Regulation | 2010 |
Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Cytokines; Disease Models, Animal; Fas Ligand Protein; Hydrocarbons, Fluorinated; In Situ Nick-End Labeling; Laminectomy; Lipid Peroxidation; Liver X Receptors; Male; Mice; Movement Disorders; Myelitis; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Orphan Nuclear Receptors; Peroxidase; Poly Adenosine Diphosphate Ribose; Proteins; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Statistics, Nonparametric; Sulfonamides; Time Factors; Tyrosine | 2010 |
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine | 2010 |
Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma.
Topics: Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Child; Female; Humans; Male; Multivariate Analysis; Nitrates; Nitric Oxide; Nitrites; Respiratory Mucosa; Spirometry; Tyrosine | 2009 |
Ultrastructural alterations in endothelial mitochondria are associated with enhanced nitrotyrosine accumulation and progressive reduction of VEGF expression in sequential protocol renal allograft biopsies with calcineurin inhibitor toxicity.
Topics: Adult; Biopsy; Calcineurin Inhibitors; Cyclosporine; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Kidney Transplantation; Male; Mitochondria; Tacrolimus; Transplantation, Homologous; Tyrosine; Vascular Endothelial Growth Factor A | 2010 |
Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.
Topics: Aging; Aldehydes; Animals; Calcium Channels; Ear, Inner; Glucuronidase; Klotho Proteins; Mice; Mice, Inbred CBA; Microscopy; Superoxide Dismutase; TRPV Cation Channels; Tyrosine | 2009 |
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.
Topics: alpha-Synuclein; Animals; Caspase 3; CD11b Antigen; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Electrochemistry; Encephalitis; Gene Expression Regulation; Male; Mitochondria; Neurodegenerative Diseases; Oxidative Stress; Rats; Rats, Inbred F344; Rotarod Performance Test; Solvents; Substantia Nigra; Trichloroethylene; Tyrosine; Tyrosine 3-Monooxygenase | 2010 |
Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi.
Topics: Animals; Cells, Cultured; Chagas Disease; Disease Models, Animal; Female; Host-Parasite Interactions; Immunity, Innate; Inflammation Mediators; Interferon-gamma; Interleukin-12 Subunit p40; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelitis; Nerve Degeneration; Nerve Growth Factors; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Paraplegia; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Spinal Cord; Trypanosoma cruzi; Tyrosine | 2010 |
Adenosine A2A receptor-selective stimulation reduces signaling pathways involved in the development of intestine ischemia and reperfusion injury.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Fas Ligand Protein; Intercellular Adhesion Molecule-1; Intestine, Small; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; P-Selectin; Peroxidase; Phenethylamines; Poly Adenosine Diphosphate Ribose; Proto-Oncogene Proteins c-bcl-2; Receptor, Adenosine A2A; Reperfusion Injury; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Proteases that can distinguish among different post-translational forms of tyrosine engineered using multicolor flow cytometry.
Topics: Amino Acid Sequence; Bacterial Outer Membrane Proteins; Escherichia coli; Escherichia coli Proteins; Flow Cytometry; Molecular Sequence Data; Peptide Hydrolases; Peptide Library; Peptides; Plasmids; Protein Engineering; Protein Processing, Post-Translational; Proteomics; Substrate Specificity; Tyrosine | 2009 |
Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid.
Topics: Aldehydes; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Down-Regulation; Electron Transport Complex I; Energy Metabolism; Epilepsy; Excitatory Amino Acid Agonists; Free Radical Scavengers; Homocysteine; Male; Metabolic Networks and Pathways; Mitochondria; Mitochondrial Diseases; Oxidative Stress; Rats; Rats, Wistar; Seizures; Survival Rate; Time Factors; Tyrosine | 2010 |
Electron capture dissociation mass spectrometry of tyrosine nitrated peptides.
Topics: Animals; Electricity; Electrons; Horses; Mass Spectrometry; Myoglobin; Nitro Compounds; Peptides; Tyrosine | 2010 |
Antioxidant therapy reverses impaired graft healing in hypercholesterolemic rabbits.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta, Abdominal; Blood Vessel Prosthesis Implantation; Cell Movement; Cell Proliferation; Cholesterol; Disease Models, Animal; Endothelial Cells; Hypercholesterolemia; Hyperplasia; Macrophages; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Rabbits; Thiobarbituric Acid Reactive Substances; Tyrosine; Wound Healing | 2010 |
[Molecular markers associated with prostate cancer: 3-nitrotyrosine and genetic and proteic expression of Mn-superoxide dismutasa (Mn-SOD)].
Topics: Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Male; Prostatic Neoplasms; Superoxide Dismutase; Tyrosine | 2009 |
Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.
Topics: Aconitate Hydratase; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Detergents; Disease Models, Animal; Disease Progression; Electrophoresis, Gel, Two-Dimensional; Humans; Immunohistochemistry; Mice; NG-Nitroarginine Methyl Ester; Protein Structure, Quaternary; Proteins; Proteomics; Reproducibility of Results; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord; Stress, Physiological; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
Cyclical estrogen and free radical damage to the rabbit urinary bladder.
Topics: Animals; Dinitrophenols; Estrogens; Female; Free Radicals; Muscle Contraction; Ovariectomy; Oxidative Stress; Rabbits; Tyrosine; Urinary Bladder | 2010 |
Beneficial effect of docosahexanoic acid and lutein on retinal structural, metabolic, and functional abnormalities in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Biomarkers; Blood Glucose; Caspase 3; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Docosahexaenoic Acids; Drug Therapy, Combination; Electroretinography; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Glutathione; Glutathione Peroxidase; In Situ Nick-End Labeling; Insulin; Lutein; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Retina; Tyrosine | 2009 |
[The protective effect of nourishing yin and promoting blood flow recipe on the aortic endothelium injury of diabetic rats].
Topics: Animals; Aorta; Blotting, Western; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Endothelium, Vascular; Female; Male; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2009 |
Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury.
Topics: Airway Obstruction; Animals; Cell Nucleus; Enzyme Activation; Hemodynamics; Indazoles; Interleukin-8; Lung Injury; Malondialdehyde; Nitrates; Nitric Oxide Synthase Type I; Nitrites; Peroxidase; Poly(ADP-ribose) Polymerases; Pressure; Regional Blood Flow; Respiratory Function Tests; Sheep; Survival Analysis; Trachea; Transcription Factor RelA; Tyrosine | 2010 |
Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cannabinoids; Caspases; Cisplatin; In Situ Nick-End Labeling; Inflammation; Kidney Diseases; Kidney Function Tests; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Peroxidase; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Receptor, Cannabinoid, CB2; Tyrosine | 2010 |
Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stress.
Topics: ADAM Proteins; ADAMTS13 Protein; Adult; Binding Sites; Blood Platelets; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Hydrolysis; Male; Methionine; Middle Aged; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Platelet Aggregation; Protein Multimerization; Ristocetin; Tyrosine; von Willebrand Diseases; von Willebrand Factor | 2010 |
Time course of intermittent hypoxia-induced impairments in resistance artery structure and function.
Topics: Acetylcholine; Analysis of Variance; Animals; Arteries; Chronic Disease; Collagen; Endothelium, Vascular; Hypoxia; Immunohistochemistry; Isoprostanes; Male; Muscle, Skeletal; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vascular Resistance; Vasodilation; Vasodilator Agents | 2010 |
Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.
Topics: Acoustic Stimulation; Adenosine; Adenosine A1 Receptor Agonists; Animals; Auditory Threshold; Cochlea; Cochlear Microphonic Potentials; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Noise-Induced; Male; Oxidative Stress; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Tyrosine | 2010 |
Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link.
Topics: Animals; Antioxidants; Ascorbic Acid; Carotid Body; Chemoreceptor Cells; Heart Rate; Hypertension; Hypoxia; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Nitrosamines; Oxidative Stress; Pulmonary Ventilation; Rats; Sleep Apnea, Obstructive; Tyrosine | 2010 |
Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats.
Topics: Actins; Aldehydes; Animals; Apoptosis; Cytoskeleton; DNA Fragmentation; Hemodynamics; Hemorrhage; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Lipid Peroxidation; Liver; Male; Neutrophils; Nitric Oxide Synthase Type III; Rats; Resuscitation; Simvastatin; Tyrosine | 2010 |
Circulating free nitrotyrosine and cognitive decline.
Topics: Adult; Aged; Aged, 80 and over; Blood Cell Count; Body Weight; Cognition Disorders; Enzyme-Linked Immunosorbent Assay; Female; Hemoglobins; Humans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Residence Characteristics; Sex Factors; Tyrosine | 2010 |
Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Lipid Peroxidation; Male; Melatonin; Neural Conduction; Niacinamide; Pain Measurement; Pain Threshold; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Streptozocin; Tyrosine; Vitamin B Complex | 2010 |
Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat.
Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blood Pressure; Fumarates; Glomerular Filtration Rate; Hypertension; Irbesartan; Kidney; Membrane Glycoproteins; Membrane Proteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Podocytes; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Tetrazoles; Tyrosine | 2010 |
Different nitrosative-induced microtubular modifications and testosterone neuroprotective effects on high-D-glucose-exposed neuroblastoma and glioma cells.
Topics: Androgens; Animals; Catalase; Cell Division; Cell Line, Transformed; Cell Survival; Down-Regulation; Drug Interactions; Glioma; Glucose; Mice; Microtubules; Neuroblastoma; Neuroglia; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Reactive Nitrogen Species; Testosterone; Tubulin; Tyrosine | 2009 |
Hyaluronan reversed proteoglycan synthesis inhibited by mechanical stress: possible involvement of antioxidant effect.
Topics: Animals; Antioxidants; Blotting, Western; Cartilage; Cattle; Chondrocytes; DNA Primers; Hyaluronic Acid; Luminescence; Nitric Oxide; Organ Culture Techniques; Peroxynitrous Acid; Proteoglycans; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Stress, Mechanical; Sulfur Radioisotopes; Superoxides; Tyrosine | 2010 |
Mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by tyrosine nitration.
Topics: Animals; Biocatalysis; Crystallography, X-Ray; Enzyme Activation; Glyceraldehyde-3-Phosphate Dehydrogenases; Models, Molecular; NAD; Protein Binding; Protein Structure, Tertiary; Rabbits; Tyrosine | 2010 |
Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons.
Topics: Apigenin; Calcium Signaling; Catechin; Cells, Cultured; Curcumin; Enzyme Activation; Flavanones; Flavonoids; Humans; Hydrolyzable Tannins; L-Lactate Dehydrogenase; NAD; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Phenols; Poly(ADP-ribose) Polymerases; Polyphenols; Quinolinic Acid; Tyrosine | 2010 |
Autonomous effects of shear stress and cyclic circumferential stretch regarding endothelial dysfunction and oxidative stress: an ex vivo arterial model.
Topics: Animals; Bradykinin; Carotid Artery, Internal; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Mechanotransduction, Cellular; Models, Animal; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Perfusion; Pulsatile Flow; Stress, Mechanical; Superoxides; Swine; Tyrosine; Vasodilation; Vasodilator Agents | 2010 |
Plant cell division is specifically affected by nitrotyrosine.
Topics: Cell Division; Cell Wall; Dinitrobenzenes; Mitosis; Nicotiana; Oryza; Plant Extracts; Seedlings; Sulfanilamides; Tubulin; Tyrosine | 2010 |
Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain; Cell Cycle Proteins; Cell Proliferation; Central Nervous System Neoplasms; DNA-Binding Proteins; Guanine; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Low Density Lipoprotein Receptor-Related Protein-2; Lymph Nodes; Lymphoma, Large B-Cell, Diffuse; Malondialdehyde; Metallothionein; Middle Aged; Minichromosome Maintenance Complex Component 7; Nuclear Proteins; Oxidative Stress; Tyrosine | 2010 |
Eccentric exercise induces nitric oxide synthase expression through nuclear factor-kappaB modulation in rat skeletal muscle.
Topics: Animals; Binding Sites; Enzyme Induction; I-kappa B Proteins; Male; Muscle Contraction; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Physical Exertion; Promoter Regions, Genetic; Pyrrolidines; Quadriceps Muscle; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Thiocarbamates; Tyrosine | 2010 |
Measurement of nitrotyrosine in plasma by immunoassays is fraught with danger: commercial availability is no guarantee of analytical reliability.
Topics: Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Tandem Mass Spectrometry; Tyrosine | 2010 |
Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Encephalitis; Female; Galectin 3; Gliosis; Hypoxia-Ischemia, Brain; Inflammation Mediators; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Degeneration; Tyrosine | 2010 |
Mass spectrometric identification of in vivo nitrotyrosine sites in the human pituitary tumor proteome.
Topics: Computational Biology; Electrophoresis, Gel, Two-Dimensional; Humans; Isoelectric Focusing; Mass Spectrometry; Pituitary Neoplasms; Proteins; Proteomics; Tyrosine | 2009 |
Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Cholesterol, LDL; Hemodynamics; Hypercholesterolemia; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitrites; Oxidative Stress; Rabbits; Simvastatin; Tyrosine | 2010 |
Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells.
Topics: Angiopoietin-1; Cell Adhesion; Cell Line, Transformed; Cell Survival; DNA Damage; Gene Expression Profiling; Humans; Hydrogen Peroxide; Integrins; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Skin; Skin Aging; Skin Neoplasms; Tyrosine | 2010 |
Electron paramagnetic resonance oximetry and redoximetry.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Electron Transport Complex IV; Free Radicals; Glutathione; Glutathione Disulfide; Immunohistochemistry; Ischemic Preconditioning; Male; Mice; NADH Dehydrogenase; Oxidation-Reduction; Oximetry; Tyrosine | 2010 |
Fcgamma receptors contribute to pyramidal cell death in the mouse hippocampus following local kainic acid injection.
Topics: Animals; Antibodies, Neutralizing; Cell Death; Cyclooxygenase 2; Hippocampus; Kainic Acid; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Microglia; Neurons; Nitric Oxide Synthase Type II; Oxidative Stress; Pyramidal Cells; Receptors, IgG; Tissue Plasminogen Activator; Tyrosine | 2010 |
Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Male; Mass Spectrometry; Myocardium; Oxidative Stress; Phosphopyruvate Hydratase; Protein Carbonylation; Rats; Rats, Wistar; Tyrosine | 2010 |
Assembly and disassembly of plant microtubules: tubulin modifications and binding to MAPs.
Topics: Microtubule-Associated Proteins; Microtubules; Mitosis; Models, Biological; Plant Cells; Plants; Protein Binding; Protein Processing, Post-Translational; Tubulin; Tyrosine | 2010 |
Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antibodies, Monoclonal; Chromatography, Liquid; Deoxyguanosine; Female; Halogens; Inflammation; Lipopolysaccharides; Liver; Mass Spectrometry; Mice; Mice, Inbred C57BL; Peroxidase; Rats; Rats, Wistar; Time Factors; Tyrosine | 2010 |
Chemical labeling and enrichment of nitrotyrosine-containing peptides.
Topics: Animals; Cattle; Mass Spectrometry; Nitrates; Peptide Fragments; Peptides; Protein Processing, Post-Translational; Proteomics; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2010 |
Oxidative stress in the progression of Alzheimer disease in the frontal cortex.
Topics: Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Antioxidants; Biomarkers; Disease Progression; Female; Frontal Lobe; Humans; Male; Mental Status Schedule; Oxidative Stress; Protein Carbonylation; Synapses; Thiobarbituric Acid Reactive Substances; Tissue Distribution; Tyrosine | 2010 |
A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Benzo(a)pyrene; Cell Line, Tumor; Cell Proliferation; Deoxyguanosine; Dinoprostone; Female; gamma-Tocopherol; Histones; Leukotriene B4; Lung Neoplasms; Mice; Neovascularization, Pathologic; Nitrosamines; Tyrosine; Xenograft Model Antitumor Assays | 2010 |
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.
Topics: Aconitate Hydratase; Animals; Cattle; Cell Respiration; Cells, Cultured; Cyclosporine; Electron Spin Resonance Spectroscopy; Endothelial Cells; Immunosuppressive Agents; Mass Spectrometry; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Superoxides; Transfection; Tyrosine | 2010 |
Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy.
Topics: Animals; Apoptosis; Arginase; Blotting, Western; Cell Count; Cell Death; Cell Survival; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nitric Oxide Synthase Type II; Nitrosation; Oxidative Stress; Oxygen; Reactive Nitrogen Species; Reactive Oxygen Species; Retinal Diseases; Retinal Neurons; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Creatine Kinase; Electrocardiography; Heart Function Tests; Hypoglycemic Agents; In Situ Nick-End Labeling; Insulin; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reperfusion Injury; Tyrosine | 2010 |
L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: prevention by propofol.
Topics: Apoptosis; Arginine; Cell Line; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Glutathione Peroxidase; Guanidines; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Oxidative Stress; Propofol; Superoxide Dismutase; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Cold exposure exacerbates the development of diabetic polyneuropathy in the rat.
Topics: Animals; Blood Glucose; Cold Temperature; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; H-Reflex; Male; Motor Neurons; Neural Conduction; Rats; Sensory Receptor Cells; Skin; Streptozocin; Tyrosine | 2009 |
Hypercapnia attenuates hypoxic pulmonary hypertension by inhibiting lung radical injury.
Topics: Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Hypercapnia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung Injury; Male; Oxidative Stress; Pulmonary Artery; Rats; Rats, Wistar; Time Factors; Tyrosine | 2009 |
Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat.
Topics: Animals; Carrageenan; Hydrogen Sulfide; Knee Joint; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Synovitis; Tyrosine | 2010 |
Oxidative stress contributes to methamphetamine-induced left ventricular dysfunction.
Topics: Actin Cytoskeleton; Animals; Antioxidants; Cardiac Catheterization; Cyclic N-Oxides; Disease Models, Animal; Male; Methamphetamine; Mitochondrial Proteins; Myocardial Contraction; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2010 |
Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration.
Topics: Aldehydes; Animals; Choroidal Neovascularization; Coloring Agents; Disease Models, Animal; Female; Fluorescein Angiography; Indocyanine Green; Light; Oxidative Stress; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Rats, Wistar; Retina; Retinal Degeneration; Tomography, Optical Coherence; Tyrosine | 2010 |
Inhibition of inducible nitric oxide synthase prevents mitochondrial damage and improves survival of steatotic partial liver grafts.
Topics: Alanine Transaminase; Animals; Bilirubin; Enzyme Inhibitors; Fatty Liver; Graft Survival; Immunohistochemistry; Liver; Liver Transplantation; Male; Mitochondria; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Sutures; Triglycerides; Tyrosine | 2010 |
Fasting induces a high level of 3-nitrotyrosine in the brain of rats.
Topics: alpha-Synuclein; Animals; Brain; Diabetes Mellitus, Experimental; Fasting; Male; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction.
Topics: Acetylcysteine; Animals; Aurintricarboxylic Acid; Biomarkers; Cattle; Cell Nucleus; Cell Survival; Female; Flow Cytometry; Fluorescence; Intracellular Space; Lipid Peroxides; Luteal Cells; Membrane Potential, Mitochondrial; Mitochondria; Molecular Imaging; Oxidation-Reduction; Progesterone; Reactive Oxygen Species; Rhodamines; Signal Transduction; Steroids; Time Factors; Tyrosine | 2010 |
A high performance liquid chromatography-electrochemical array method for the measurement of oxidative/nitrative changes in human urine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Chromatography, High Pressure Liquid; Deoxyguanosine; Electrochemical Techniques; Female; Humans; Hydrogen-Ion Concentration; Linear Models; Male; Oxidative Stress; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tyrosine | 2010 |
Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Bruch Membrane; Chromatography, High Pressure Liquid; Humans; Lipofuscin; Mass Spectrometry; Middle Aged; Nitrosation; Pyridinium Compounds; Retinoids; Tyrosine | 2010 |
Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes.
Topics: 3T3-L1 Cells; 8-Hydroxy-2'-Deoxyguanosine; Adipocytes; Adiponectin; Animals; Antioxidants; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Glucose; Metalloporphyrins; Mice; Mitochondria; Resistin; Superoxides; Thenoyltrifluoroacetone; Tyrosine | 2010 |
Energy transfer ligands of the GluR2 ligand binding core.
Topics: Animals; Binding, Competitive; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; Ligands; Models, Chemical; Protein Binding; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Rats; Receptors, AMPA; Tryptophan; Tyrosine | 2010 |
Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Aldehydes; Animals; Apoptosis; Caspase 3; Catheter Ablation; Combined Modality Therapy; Deoxyguanosine; DNA Damage; Doxorubicin; Female; Histones; HSP70 Heat-Shock Proteins; Immunoenzyme Techniques; Mammary Neoplasms, Experimental; Oxidative Stress; Rats; Rats, Inbred F344; Tyrosine | 2010 |
Increased oxidative stress and cardiomyocyte myofibrillar degeneration in patients with chronic isolated mitral regurgitation and ejection fraction >60%.
Topics: Adult; Aged; Biopsy; Blotting, Western; Case-Control Studies; Female; Humans; Immunohistochemistry; Lipofuscin; Magnetic Resonance Imaging, Cine; Male; Microscopy, Electron, Transmission; Middle Aged; Mitral Valve Insufficiency; Myocardium; Myocytes, Cardiac; Oxidative Stress; Postoperative Period; Preoperative Period; Stroke Volume; Tyrosine; Ventricular Dysfunction, Left; Xanthine Dehydrogenase; Xanthine Oxidase | 2010 |
Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury.
Topics: Animals; Apoptosis; Cytokines; Enzyme Induction; Fas Ligand Protein; Male; Mice; Neutrophil Infiltration; Nitric Oxide Synthase; Peroxidase; PPAR delta; PPAR-beta; Spinal Cord Injuries; Sulfones; Thiazoles; Thiophenes; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Relative efficacy of casein or soya protein combined with palm or safflower-seed oil on hyperuricaemia in rats.
Topics: Albumins; Analysis of Variance; Animals; Blood Urea Nitrogen; Caseins; Cholesterol; Creatinine; Diet; Dietary Fats; Dietary Proteins; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Glycine max; Hyperuricemia; Insulin; Interferon-gamma; Kidney; Kidney Calculi; Male; Nephritis, Interstitial; Nitric Oxide; Oxonic Acid; Palm Oil; Plant Oils; Rats; Rats, Wistar; Safflower Oil; Soybean Proteins; Transforming Growth Factor beta; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 2010 |
Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin.
Topics: Aconitate Hydratase; Animals; Antioxidants; Cell Cycle; Female; Liver Regeneration; Male; Mice; Mice, Transgenic; Mitochondria; Proliferating Cell Nuclear Antigen; Sex Factors; Signal Transduction; Superoxide Dismutase; Thioredoxins; Tyrosine; Up-Regulation | 2010 |
Functional impairment of the arterial wall in primary Sjögren's syndrome: combined action of immunologic and inflammatory factors.
Topics: Adult; Atherosclerosis; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Female; Humans; Intercellular Adhesion Molecule-1; Matched-Pair Analysis; Middle Aged; Reference Values; Sjogren's Syndrome; Statistics, Nonparametric; Tyrosine; Vascular Cell Adhesion Molecule-1; Vasodilation | 2010 |
Rigid hydrophilic structures for improved properties of conjugated polymers and nitrotyrosine sensing in water.
Topics: Alkynes; Crystallography, X-Ray; Ethers; Models, Molecular; Molecular Structure; Solubility; Stereoisomerism; Tyrosine; Water | 2010 |
Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain.
Topics: alpha-Tocopherol; Animals; Biomarkers; Brain; Chemoprevention; Drug Therapy, Combination; Free Radical Scavengers; Insecticides; Lipid Peroxidation; Malathion; Male; Mitochondria; Oxidative Stress; Oxidoreductases; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Tyrosine | 2010 |
Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.
Topics: Aging; Animals; Creatine Kinase; Glycogen Phosphorylase; Kinetics; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Oxidative Stress; Protein Carbonylation; Tyrosine | 2009 |
Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle.
Topics: Adaptation, Physiological; Age Factors; Aging; Animals; Blotting, Western; Calcium; Exercise Test; HSP70 Heat-Shock Proteins; Male; Muscle, Skeletal; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Protein Carbonylation; Rats; Rats, Inbred F344; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2010 |
Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity.
Topics: Adult; Aged; Biomarkers; Disease Progression; Female; Health Status; Humans; Lupus Erythematosus, Systemic; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Severity of Illness Index; Superoxide Dismutase; Tyrosine; Young Adult | 2010 |
Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma, Mucinous; Antioxidants; Biomarkers, Tumor; Deoxyguanosine; Female; Humans; Immunohistochemistry; Neoplasm Proteins; Ovarian Neoplasms; Oxidative Stress; Peroxiredoxins; Reactive Oxygen Species; Thioredoxins; Tyrosine | 2010 |
IL-2 and IFN-gamma in the retina of diabetic rats.
Topics: Animals; Cataract; Chemokines; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Interferon-gamma; Interleukin-10; Interleukin-1alpha; Interleukin-1beta; Interleukin-2; Interleukin-4; Interleukin-6; Interleukin-8; Male; Nitric Oxide; Rats; Rats, Long-Evans; Retina; T-Lymphocytes, Helper-Inducer; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Protein nitration, lipid peroxidation and DNA damage at high altitude in acclimatized lowlanders and native highlanders: relation with oxygen consumption.
Topics: Acclimatization; Adult; Altitude; Biomarkers; DNA Damage; Exercise; Humans; Lipid Peroxidation; Male; Oxidative Stress; Oxygen; Oxygen Consumption; Random Allocation; Rest; Tyrosine | 2010 |
Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy.
Topics: Animals; Antioxidants; Cytokines; Drugs, Chinese Herbal; Glutathione; Hepatectomy; Inflammation Mediators; Iridoid Glycosides; Iridoids; Liver; Male; Nitric Oxide Synthase; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Reperfusion Injury; Survival Rate; Transaminases; Tyrosine | 2010 |
Suppression of allergen-induced respiratory dysfunction and airway inflammation in sensitized guinea pigs by Mn(II)(Me(2)DO2A), a novel superoxide scavenger compound.
Topics: Allergens; Anaphylaxis; Animals; Anti-Asthmatic Agents; Apoptosis; Asthma; Bronchoconstriction; Caspase 3; Free Radical Scavengers; Guinea Pigs; Male; Mast Cells; Organometallic Compounds; Ovalbumin; Peroxidase; Superoxides; Thiobarbituric Acid Reactive Substances; Tyrosine | 2010 |
3-nitro-tyrosine as an internal quencher of autofluorescence enhances the compatibility of fluorescence based screening of OBOC combinatorial libraries.
Topics: Combinatorial Chemistry Techniques; Fluorescence; High-Throughput Screening Assays; Peptide Library; Tyrosine | 2010 |
Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen.
Topics: Animals; Chemokine CCL2; Hyperoxia; Intercellular Adhesion Molecule-1; Lung; Lung Injury; Mice; Nitric Oxide; Oxygen; Peroxidase; Tyrosine | 2010 |
Quantification of nitrotyrosine in nitrated proteins.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Kinetics; Ovalbumin; Proteins; Serum Albumin, Bovine; Tyrosine | 2010 |
Science to practice: will randomized prospective clinical trials be necessary for RF ablation of large liver tumors with liposomal doxorubicin?
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adenocarcinoma; Aldehydes; Animals; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Catheter Ablation; Chemotherapy, Adjuvant; Combined Modality Therapy; Deoxyguanosine; DNA Damage; Doxorubicin; Histones; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms; Mammary Neoplasms, Experimental; Oxidative Stress; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Tyrosine | 2010 |
Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.
Topics: Acute Disease; Animals; Chemokine CX3CL1; Colitis; CX3C Chemokine Receptor 1; Cytokines; Dextran Sulfate; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Receptors, Chemokine; Tyrosine | 2010 |
Exogenous SOD mimetic tempol ameliorates the early retinal changes reestablishing the redox status in diabetic hypertensive rats.
Topics: Animals; Blotting, Western; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fibronectins; Glial Fibrillary Acidic Protein; Glutathione; Hypertension; Immunoenzyme Techniques; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Superoxide Dismutase; Tyrosine | 2010 |
Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress.
Topics: Animals; Animals, Newborn; Brain; Hypercapnia; Neurodegenerative Diseases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-{alpha}.
Topics: Animals; Blotting, Western; Diabetic Neuropathies; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Nitrates; Nitrites; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Expression of 3-nitrotyrosine, a marker for peroxynitrite, in nasal polyps of nonatopic patients.
Topics: Adult; Epithelium; Female; Free Radicals; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Metaplasia; Models, Biological; Nasal Mucosa; Nasal Polyps; Oxygen; Peroxynitrous Acid; Tyrosine | 2010 |
Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Drug Combinations; Fluid Therapy; Goats; Hemodynamics; Inflammation; Infusions, Intravenous; Isotonic Solutions; Lactates; Leukocyte Count; Male; Myocardium; Neutrophils; Oxidative Stress; Pyruvic Acid; Resuscitation; Ringer's Lactate; Shock, Hemorrhagic; Treatment Outcome; Tyrosine | 2010 |
Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder.
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Depressive Disorder, Major; Electron Transport Complex I; Female; Humans; Male; Middle Aged; Mitochondrial Proteins; NADH Dehydrogenase; Oxidative Stress; Prefrontal Cortex; Schizophrenia; Tyrosine | 2010 |
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
Topics: Allergens; Animals; Antigens, Dermatophagoides; Arginase; Arginine; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Tyrosine | 2010 |
Neonatal asphyxia induces the nitration of cardiac myosin light chain 2 that is associated with cardiac systolic dysfunction.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blotting, Western; Cardiac Myosins; Electrophoresis, Gel, Two-Dimensional; Heart Failure; Hemodynamics; Humans; Immunoprecipitation; Infant, Newborn; Myosin Light Chains; Nitrates; Nitrites; Swine; Tyrosine | 2010 |
Pathological, biochemical and haematological investigations on the protective effect of alpha-lipoic acid in experimental aflatoxin toxicosis in chicks.
Topics: Aflatoxins; Animals; Antioxidants; Apoptosis; Blood Cell Count; Chickens; Female; Hematocrit; Hemoglobins; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Malondialdehyde; Nitric Oxide Synthase Type II; Poultry Diseases; Random Allocation; Thioctic Acid; Tyrosine | 2010 |
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.
Topics: Aged; alpha-Synuclein; Antiparkinson Agents; Autophagy; Female; Gene Frequency; Genotype; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Promoter Regions, Genetic; Reactive Oxygen Species; Sex Distribution; Tyrosine | 2010 |
Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Case-Control Studies; Electrophoresis, Gel, Two-Dimensional; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipid Peroxidation; Male; Oxidative Stress; Parietal Lobe; Peptide Fragments; Protein Carbonylation; Proteomics; Spectrum Analysis; Tyrosine | 2010 |
Long-term vitamin A supplementation at therapeutic doses induces mitochondrial electrons transfer chain (METC) impairment and increased mitochondrial membrane-enriched fraction (MMEF) 3-nitrotyrosine on rat heart.
Topics: Animals; Dietary Supplements; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Enzyme-Linked Immunosorbent Assay; Heart; Male; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Oxidative Stress; Rats; Time Factors; Tyrosine; Vitamin A | 2010 |
GW0742, a high-affinity PPAR -beta/delta agonist, inhibits acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Carrageenan; I-kappa B Proteins; Lipid Peroxidation; Lung; Male; Mice; Neutrophils; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Pleurisy; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Experimental; Cartilage; Collagen Type II; Cytokines; Disease Models, Animal; Edema; Female; Ginsenosides; Hyperplasia; Inflammation; Interleukin-1beta; Joint Capsule; Joints; Lipopolysaccharides; Male; Malondialdehyde; Matrix Metalloproteinase 3; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Oxidative Stress; Panax; Phytotherapy; Plant Extracts; Plant Roots; Spleen; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Efficient identification and quantification of peptides containing nitrotyrosine by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry after derivatization.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Cattle; Molecular Sequence Data; Peptides; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2010 |
Peroxynitrite and hemoglobin-mediated nitrative/oxidative modification of human plasma protein: effects of some flavonoids.
Topics: Antioxidants; Blood Proteins; Flavonoids; Free Radical Scavengers; Hemoglobins; Humans; Molecular Structure; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2010 |
Insulin and IGF-1 receptors, nitrotyrosin and cerebral neuronal deficits in two young patients with diabetic ketoacidosis and fatal brain edema.
Topics: Adolescent; Biomarkers; Brain Edema; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Disease Progression; Fatal Outcome; Female; Humans; Insulin; Receptor, IGF Type 1; Tyrosine | 2010 |
Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model.
Topics: Administration, Inhalation; Aldehydes; Animals; Antioxidants; Aquaporin 4; Brain Damage, Chronic; Cerebral Hemorrhage; Disease Progression; Drug Evaluation, Preclinical; Extracellular Matrix Proteins; Glucose; Hydrogen; Hyperglycemia; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice.
Topics: Actins; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Catechin; Chemical and Drug Induced Liver Injury; Collagen Type I; Cyclooxygenase 2 Inhibitors; Liver Cirrhosis; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Deficiency of lung antioxidants in idiopathic pulmonary arterial hypertension.
Topics: Adult; Antioxidants; Blood Pressure; Bronchi; Bronchoalveolar Lavage Fluid; Female; Humans; Hypertension, Pulmonary; Lung; Male; Models, Biological; Nitric Oxide; Respiratory Mucosa; Superoxide Dismutase; Systole; Tyrosine | 2008 |
Mediterranean diet and red wine protect against oxidative damage in young volunteers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Antioxidants; Chile; Deoxyguanosine; Diet, Mediterranean; DNA; Erythrocytes; Humans; Leukocytes; Male; Oxidative Stress; Risk Factors; Time Factors; Tyrosine; Wine | 2010 |
Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport.
Topics: Activating Transcription Factor 3; Animals; Axonal Transport; Axons; Demyelinating Diseases; Ganglia, Spinal; Gene Knockdown Techniques; Immunohistochemistry; In Vitro Techniques; Lysophosphatidylcholines; Microscopy, Electron; Mitochondria; Myelin Sheath; Oxidative Stress; Rats; Rats, Sprague-Dawley; Schwann Cells; Tyrosine | 2010 |
Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats.
Topics: Aging; Animals; Geniculate Bodies; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Inbred F344; Tyrosine | 2010 |
Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Cytokines; Gene Deletion; Glucose Clamp Technique; Hyperinsulinism; Inflammation; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nitric Oxide Synthase Type II; Oxygen Consumption; Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Heart; Hyperglycemia; Immunoblotting; Immunoprecipitation; Mice; Myocardial Reperfusion Injury; Nitrates; Nitrosation; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Thioredoxins; Tyrosine | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Hyperplasia; Inflammation; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oxidative Stress; Phenobarbital; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Messenger; Stilbenes; Tyrosine | 2010 |
Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice.
Topics: Animals; Calcium Signaling; Catalase; Cells, Cultured; Cysteine; Disease Models, Animal; Down-Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; Mice; Mice, Transgenic; Myocardial Contraction; Myocytes, Cardiac; Oxidation-Reduction; Protein Processing, Post-Translational; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Up-Regulation; Ventricular Dysfunction, Left | 2010 |
Protein tyrosine nitration of aldolase in mast cells: a plausible pathway in nitric oxide-mediated regulation of mast cell function.
Topics: Cell Degranulation; Cell Line, Tumor; Cells, Cultured; Fructose-Bisphosphate Aldolase; Glycolysis; Humans; Immunophenotyping; Mast Cells; Nitric Oxide; Nitric Oxide Donors; Protein Processing, Post-Translational; S-Nitrosoglutathione; Signal Transduction; Substrate Specificity; Tyrosine | 2010 |
Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glucose Tolerance Test; Hyperglycemia; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Molecular Structure; Niacinamide; Piperidines; Streptozocin; Tyrosine | 2010 |
Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage.
Topics: Animals; Arterioles; Blotting, Western; Caspase 3; Cerebral Arteries; Fibrinogen; Immunohistochemistry; In Situ Nick-End Labeling; Intracranial Thrombosis; Lac Operon; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Subarachnoid Hemorrhage; Superoxides; Tyrosine; Vasospasm, Intracranial | 2011 |
Site-specific incorporation of 3-nitrotyrosine as a probe of pKa perturbation of redox-active tyrosines in ribonucleotide reductase.
Topics: Biocatalysis; Catalytic Domain; Escherichia coli; Hydrogen-Ion Concentration; Models, Molecular; Oxidation-Reduction; Protein Binding; Protein Subunits; Ribonucleotide Reductases; RNA, Transfer; Substrate Specificity; Tyrosine | 2010 |
Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells.
Topics: Acetazolamide; Antigens, Neoplasm; Apoptosis; Blotting, Western; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; Carbonic Anhydrase IX; Carbonic Anhydrases; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Ceramides; Flow Cytometry; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Neoplasms; p38 Mitogen-Activated Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2010 |
Intermittent high glucose enhances cell proliferation and VEGF expression in retinal endothelial cells: the role of mitochondrial reactive oxygen species.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Blotting, Northern; Cell Proliferation; Cells, Cultured; Deoxyguanosine; Dose-Response Relationship, Drug; Endothelium; Enzyme-Linked Immunosorbent Assay; Glucose; Humans; Oxidative Stress; Reactive Oxygen Species; Retina; Tyrosine; Vascular Endothelial Growth Factor A | 2010 |
Effect of CRH on NO bioavailability, ROS production and antioxidant defense systems in endothelial EAhy926 cells.
Topics: Antioxidants; Catalase; Cell Line; Corticotropin-Releasing Hormone; Culture Media, Conditioned; Endothelial Cells; Glutathione; Humans; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Peptide Fragments; Peptides, Cyclic; Pyrimidines; Pyrroles; Reactive Oxygen Species; Receptors, Corticotropin-Releasing Hormone; Superoxide Dismutase; Tyrosine | 2010 |
Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling.
Topics: Animals; Bleomycin; Cell Proliferation; Early Growth Response Protein 1; Extracellular Space; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Lung; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type III; Nitrosation; Oxidation-Reduction; Pulmonary Artery; Pulmonary Fibrosis; Stress, Physiological; Superoxide Dismutase; Transforming Growth Factor beta; Tyrosine | 2011 |
[Effects of different severities of hypoxia-ischemia on brain injury in neonatal rats].
Topics: Animals; Animals, Newborn; Apoptosis; Hypoxia-Ischemia, Brain; Magnetic Resonance Imaging; Microglia; Microtubule-Associated Proteins; Rats; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes.
Topics: Animals; Antioxidants; Cell Respiration; Diabetes Mellitus, Type 2; Disease Models, Animal; Electron Transport; Electron Transport Chain Complex Proteins; Ion Channels; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Mitochondrial Proteins; Mitochondrial Proton-Translocating ATPases; Mitochondrial Size; Oxidative Stress; Protein Processing, Post-Translational; Proteome; Proteomics; Tyrosine; Uncoupling Protein 3 | 2010 |
TRPV4 channels augment macrophage activation and ventilator-induced lung injury.
Topics: Animals; Disease Susceptibility; Genotype; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Immunohistochemistry; In Vitro Techniques; Lung; Macrophage Activation; Macrophages, Alveolar; Mice; Mice, Knockout; Permeability; Phorbol Esters; Pulmonary Edema; Pulmonary Ventilation; Reactive Nitrogen Species; Reactive Oxygen Species; Staining and Labeling; TRPC Cation Channels; Tyrosine; Ventilator-Induced Lung Injury | 2010 |
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.
Topics: Animals; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Lysine; Mice; Mice, Knockout; Muscle, Skeletal; Oxidation-Reduction; Shc Signaling Adaptor Proteins; Skin; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Wound Healing | 2010 |
Neuroglobin protects neurons against oxidative stress in global ischemia.
Topics: Animals; Brain Ischemia; Catalase; Globins; Glutathione Peroxidase; Hippocampus; Humans; Lipid Peroxidation; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuroglobin; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tyrosine; Up-Regulation | 2010 |
Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Flavonols; Humans; Hydrogen Peroxide; Luteolin; Molecular Structure; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; Quercetin; Reactive Oxygen Species; Tyrosine; Weightlessness | 2010 |
Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability.
Topics: Aged; Aged, 80 and over; Biomarkers; Blotting, Western; Carotid Artery, Internal; Carotid Stenosis; Case-Control Studies; Disease Progression; Endarterectomy, Carotid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Lipoproteins, LDL; Male; Malondialdehyde; Matrix Metalloproteinase 9; Middle Aged; Oxidative Stress; Prospective Studies; Protein Carbonylation; Rupture; Severity of Illness Index; Tyrosine; Up-Regulation | 2010 |
Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice.
Topics: Animals; Aorta; Blood Flow Velocity; Collagen; Compliance; Elastin; Extracellular Matrix; Hyperhomocysteinemia; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Tissue Inhibitor of Metalloproteinases; Tyrosine; Ultrasonography | 2010 |
Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Carbolines; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Kidney; Male; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Tyrosine | 2010 |
Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules.
Topics: Adult; Antioxidants; Chlorogenic Acid; Coffee; Comet Assay; Dinoprost; DNA Damage; Female; Humans; Lipid Peroxidation; Lymphocytes; Macromolecular Substances; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Tyrosine; Young Adult | 2010 |
The role of nitric oxide, superoxide and peroxynitrite in the anti-arrhythmic effects of preconditioning and peroxynitrite infusion in anaesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Female; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Male; Nitric Oxide; Peroxynitrous Acid; Reactive Nitrogen Species; Superoxides; Tyrosine | 2010 |
Glutamine treatment attenuates the development of ischaemia/reperfusion injury of the gut.
Topics: Animals; Apoptosis; Cell Adhesion Molecules; Glutamine; I-kappa B Kinase; Ileal Diseases; Ileum; Male; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Poly Adenosine Diphosphate Ribose; Protein Transport; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splanchnic Circulation; Time Factors; Tyrosine | 2010 |
Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lung; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Poly Adenosine Diphosphate Ribose; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Sheep; Time Factors; Tyrosine | 2010 |
Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Biomarkers, Tumor; Breast Neoplasms; Deoxyguanosine; DNA Damage; Female; Humans; Middle Aged; Nitrates; Nitrites; Nitrosation; Oxidation-Reduction; Oxidative Stress; Prognosis; Thiobarbituric Acid Reactive Substances; Tyrosine | 2010 |
Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.
Topics: Animals; Antioxidants; Apolipoproteins E; Biopterins; GTP Cyclohydrolase; Isoenzymes; Male; Malondialdehyde; Mice; Mice, Knockout; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stilbenes; Superoxide Dismutase; Superoxides; Tyrosine | 2010 |
Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease.
Topics: Albuminuria; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Hypertrophy; Immunohistochemistry; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Transforming Growth Factor beta1; Tyrosine | 2010 |
Arachidonic acid inhibits neuronal nitric oxide synthase elicited by proinflammatory stimuli and promotes astrocyte survival with both exogenous and endogenous peroxynitrite via different mechanisms.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Immunohistochemistry; Inflammation; Lipoxygenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2010 |
The nitrative and oxidative stress in blood platelets isolated from breast cancer patients: the protectory action of aronia melanocarpa extract.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Blood Proteins; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Middle Aged; Oxidative Stress; Photinia; Plant Extracts; Tyrosine | 2010 |
Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters.
Topics: Animals; Antioxidants; Bile Ducts; Cricetinae; Cytokines; DNA Damage; Down-Regulation; Gene Expression Regulation; Heme Oxygenase-1; Liver; Melatonin; NF-E2-Related Factor 2; Opisthorchiasis; Opisthorchis; Oxidative Stress; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Hyperoxia; Ischemic Attack, Transient; Male; Middle Cerebral Artery; Nitrates; Nitric Acid; Nitrites; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Attenuated cardiovascular hypertrophy and oxidant generation in response to angiotensin II infusion in glutaredoxin-1 knockout mice.
Topics: Actin Cytoskeleton; Angiotensin II; Animals; Aorta; Cardiovascular Diseases; Cell Line; Glutaredoxins; Hypertrophy; Infusion Pumps; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nitric Oxide Synthase Type II; Oncogene Protein v-akt; Oxidants; RNA, Small Interfering; Tyrosine | 2010 |
ApoA-1 mimetic peptide reverses uremia-induced upregulation of pro-atherogenic pathways in the aorta.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta, Thoracic; Apolipoprotein A-I; Arachidonate 12-Lipoxygenase; Arteritis; Atherosclerosis; Chemokine CCL2; Cyclooxygenase 2; Male; NADPH Oxidases; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase Type II; Oxidative Stress; Peptides; Peroxidase; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Tyrosine; Up-Regulation; Uremia | 2010 |
Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Coumaric Acids; Disease Models, Animal; Free Radical Scavengers; Gene Expression Regulation; Male; Neuroprotective Agents; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reperfusion Injury; Tyrosine | 2010 |
Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats.
Topics: 2,4-Dinitrophenol; Aldehydes; Animals; Antioxidants; Apoptosis; Blood Glucose; Diet; Flavanones; Fructose; Hepatocytes; Insulin; Insulin Resistance; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2010 |
Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis.
Topics: Antigens, CD34; Biomarkers, Tumor; Bone Neoplasms; Chondrosarcoma; Cyclooxygenase 2; Humans; Immunohistochemistry; Neoplasm Staging; Neovascularization, Pathologic; Nitric Oxide Synthase; Predictive Value of Tests; Prognosis; Survival Analysis; Tyrosine | 2010 |
Melatonin reduces hyperalgesia associated with inflammation.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melatonin; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Signal Transduction; Superoxides; Tyrosine | 2010 |
Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates.
Topics: Animals; Blood Vessels; Blotting, Western; DNA; Electron Transport Complex IV; Female; Macaca mulatta; Mitochondria, Muscle; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Tobacco Smoke Pollution; Tyrosine | 2010 |
Plasma nitroproteome of kidney disease patients.
Topics: Aged; Aged, 80 and over; Amino Acid Sequence; Blood Proteins; Case-Control Studies; Chronic Disease; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Kidney Diseases; Male; Middle Aged; Molecular Sequence Data; Protein Processing, Post-Translational; Proteome; Tandem Mass Spectrometry; Tyrosine | 2011 |
Protein changes in macrophages induced by plasma from rats exposed to 35 GHz millimeter waves.
Topics: Animals; Blood Proteins; Cell Line; Electromagnetic Fields; Gene Expression Regulation; Hot Temperature; Macrophages; Male; Proteomics; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers.
Topics: Animals; Blood Glucose; Blood Pressure; Cells, Cultured; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Humans; Kidney Glomerulus; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NADPH Oxidase 4; NADPH Oxidases; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Smoking; Tyrosine | 2010 |
Construction of confidence regions for isotopic abundance patterns in LC/MS data sets for rigorous determination of molecular formulas.
Topics: Chenodeoxycholic Acid; Chromatography, Liquid; Confidence Intervals; Hippurates; Ions; Mass Spectrometry; Metabolome; Models, Theoretical; Tyrosine | 2010 |
On-line bioaffinity-electrospray mass spectrometry for simultaneous detection, identification, and quantification of protein-ligand interactions.
Topics: Amino Acid Sequence; Antibodies, Immobilized; Antibodies, Monoclonal; Biosensing Techniques; Humans; Lectins; Microchip Analytical Procedures; Protein Binding; Protein Interaction Mapping; Proteins; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2010 |
Sex differences in nitrosative stress during renal ischemia.
Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Enzyme Activation; Female; Glomerular Filtration Rate; Kidney Medulla; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Multimerization; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reperfusion Injury; Sex Factors; Sulfhydryl Compounds; Time Factors; Tyrosine | 2010 |
Effects of dietary glutamine on adhesion molecule expression and oxidative stress in mice with streptozotocin-induced type 1 diabetes.
Topics: Analysis of Variance; Animals; Blood Glucose; Cell Adhesion Molecules; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diet; Dietary Supplements; Fructosamine; Glutamine; Glutathione; Insulin; Insulin Secretion; Leukocytes; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Streptozocin; Tyrosine | 2011 |
Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Tyrosine; Vascular Resistance; Ventricular Dysfunction, Right | 2010 |
Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain.
Topics: Acetylcarnitine; Aldehydes; Animals; Astrocytes; Brain; Ethanol; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; Synaptic Transmission; Tyrosine | 2010 |
Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve.
Topics: Animals; Apoptosis; Brain Ischemia; Ghrelin; Humans; Immunohistochemistry; Inflammation; Interleukin-6; Male; Matrix Metalloproteinase 9; Neutrophils; Nitric Oxide Synthase Type I; Peroxidase; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Tyrosine; Vagotomy; Vagus Nerve | 2011 |
Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats.
Topics: Alanine Transaminase; Animals; Blood Transfusion; Camellia sinensis; Cytokines; Female; Flavonoids; Lipid Peroxidation; Liver; Liver Diseases; Nitric Oxide Synthase Type II; Phenols; Phytotherapy; Plant Extracts; Polyphenols; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; Resuscitation; Shock, Hemorrhagic; Tyrosine | 2010 |
Internal exposure, effect monitoring, and lung function in welders after acute short-term exposure to welding fumes from different welding processes.
Topics: Adult; Air Pollutants, Occupational; Breath Tests; Chromium; Cross-Over Studies; Environmental Monitoring; Humans; Iron; Male; Middle Aged; Nickel; Nitrates; Nitrites; Occupational Exposure; Osteopontin; Respiratory Function Tests; Respiratory Physiological Phenomena; Tyrosine; Welding; Young Adult | 2010 |
Efficacy of treatment with verbascoside, biotechnologically produced by Syringa vulgaris plant cell cultures in an experimental mice model of spinal cord trauma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Culture Techniques; Chromatography, High Pressure Liquid; Disease Models, Animal; Glucosides; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Interleukin-1beta; Male; Mice; Mice, Inbred Strains; Motor Activity; Nitric Oxide Synthase Type II; Phenols; Plant Extracts; Poly Adenosine Diphosphate Ribose; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Spinal Cord; Spinal Cord Injuries; Syringa; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Endothelial NOS-derived nitric oxide prevents injury resulting from reoxygenation in the hypoxic lung.
Topics: Animals; Cytoprotection; Enzyme Inhibitors; Hypoxia; In Situ Nick-End Labeling; Lung; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Ornithine; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; Thiobarbituric Acid Reactive Substances; Tyrosine | 2010 |
Increased nitration and diminished activity of copper/zinc superoxide dismutase in placentas from diabetic rats.
Topics: Amino Acid Sequence; Animals; Cattle; Diabetes Mellitus, Experimental; Female; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Nitric Oxide; Peroxynitrous Acid; Placenta; Pregnancy; Rats; Rats, Wistar; Sequence Alignment; Streptozocin; Superoxide Dismutase; Tyrosine | 2010 |
Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.
Topics: Aldehydes; Animals; Antioxidants; Apolipoproteins E; Atherosclerosis; Azoles; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Isoindoles; Kidney; Male; Mice; Mice, Knockout; Organoselenium Compounds; Reactive Oxygen Species; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2010 |
Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity.
Topics: Animals; Bleomycin; Bronchi; Cell Line, Tumor; Collagen; Cyclic AMP; Cyclic GMP; Fibroblasts; Goblet Cells; Humans; Lung; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Monocytes; Muscle, Smooth; Nitric Oxide; Peptides; Peroxidase; Pulmonary Fibrosis; Receptors, G-Protein-Coupled; Receptors, Peptide; Relaxin; Signal Transduction; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta1; Tyrosine | 2010 |
Effect of endurance exercise training on oxidative stress in spontaneously hypertensive rats (SHR) after emergence of hypertension.
Topics: Age Factors; Aldehydes; Animals; Aorta; Blood Pressure; Coronary Artery Disease; Fluoroimmunoassay; Hypertension; Motor Activity; Nitric Oxide; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Inbred SHR; Superoxide Dismutase; Superoxides; Tyrosine | 2010 |
Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides.
Topics: Amino Acid Sequence; Electrons; Nitrates; Peptides; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2010 |
The nitric oxide donor molsidomine rescues cardiac function in rats with chronic kidney disease and cardiac dysfunction.
Topics: Administration, Oral; Animals; Biomarkers; Cardiotonic Agents; Creatinine; Disease Models, Animal; Gene Expression Regulation; Kidney Diseases; Male; Molsidomine; Myocardial Contraction; Myocardium; Nephrectomy; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Rats; Rats, Inbred Lew; Stroke Volume; Time Factors; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2010 |
Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Heart; Hypertension; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Periodontitis; Peroxidase; Radiography; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Neuroprotective effects of almond skins in experimental spinal cord injury.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Inflammation; Lipid Peroxidation; Male; Mice; Neuroprotective Agents; Neutrophil Infiltration; NF-kappa B; Plant Extracts; Plant Structures; Prunus; Spinal Cord Injuries; Tyrosine | 2011 |
L-Carnitine protects plasma components against oxidative alterations.
Topics: Adult; Antioxidants; Blood Proteins; Carnitine; Cysteine; Dietary Supplements; Glutathione; Homocysteine; Humans; Lipid Peroxides; Lipids; Male; Osmolar Concentration; Oxidants; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Tyrosine; Young Adult | 2011 |
Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation.
Topics: Alveolar Bone Loss; Animals; Antioxidants; Camellia sinensis; Catechin; Connective Tissue; Dentifrices; Disease Models, Animal; Epithelial Attachment; Gingiva; Gingival Recession; Lipid Peroxidation; Lysine; Male; NF-kappa B; Oxidative Stress; Periodontitis; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.
Topics: Animals; Biopterins; Cold Ischemia; Male; Mice; Mice, Inbred C57BL; Microcirculation; Models, Animal; Pancreas; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Tissue Donors; Transplantation, Isogeneic; Tyrosine | 2010 |
Using blood pressure telemetry to assess acute changes in arterial stiffness in rats after nitric oxide synthase inhibition or environmental tobacco smoke exposure.
Topics: Animals; Arteries; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Elasticity; Environmental Exposure; Enzyme Inhibitors; Male; Nicotiana; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Smoke; Telemetry; Tyrosine; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase.
Topics: Absorption; Adenosine Triphosphate; Biocatalysis; Diphosphates; Electron Spin Resonance Spectroscopy; Electron Transport; Escherichia coli; Free Radicals; Kinetics; Models, Molecular; Oxidants; Protein Conformation; Protons; Ribonucleotide Reductases; Tyrosine | 2010 |
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Biopterins; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme System; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Intramolecular Oxidoreductases; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Receptors, Immunologic; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2011 |
Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury.
Topics: Acetophenones; Animals; Apoptosis; Cell Adhesion Molecules; Cytokines; Gene Expression; Immunohistochemistry; Laminectomy; Male; Mice; Mitogen-Activated Protein Kinases; Models, Animal; Motor Activity; Myelitis; NADPH Oxidases; Neutrophil Infiltration; NF-kappa B; Poly Adenosine Diphosphate Ribose; Reactive Oxygen Species; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2011 |
Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzamides; Bridged Bicyclo Compounds; Gene Expression Regulation, Enzymologic; Indomethacin; Intestine, Small; Macrophages; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nitric Oxide Synthase Type II; Peroxidase; Receptors, Nicotinic; RNA, Messenger; Tyrosine; Ulcer | 2011 |
Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Curcumin; Diet; Electron Transport Complex I; Esters; Flavonoids; Glutamates; Mice; Mitochondria; Mitochondrial Proteins; Mitochondrial Swelling; Parkinson Disease; Peroxynitrous Acid; Phenols; Polyphenols; Protective Agents; Tyrosine | 2011 |
Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death.
Topics: Alanine Transaminase; Animals; Bilirubin; Death; Enzyme Inhibitors; Graft Rejection; Graft Survival; Imines; Liver; Liver Transplantation; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Necrosis; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Reactive Nitrogen Species; Tyrosine | 2010 |
Role and mechanism of uncoupling protein 2 on the fatty acid-induced dysfunction of pancreatic alpha cells in vitro.
Topics: Animals; Cells, Cultured; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin Receptor Substrate Proteins; Ion Channels; Iridoid Glycosides; Iridoids; Mice; Mitochondrial Proteins; Oxidative Stress; Palmitic Acid; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; RNA, Messenger; Signal Transduction; Trans-Activators; Transcription Factors; Tyrosine; Uncoupling Protein 2 | 2010 |
Evaluation of oxidative and nitrosative stress in hemodialysis patients.
Topics: Antioxidants; Biomarkers; Body Mass Index; Case-Control Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peroxidase; Renal Dialysis; Tyrosine | 2010 |
Pulmonary exposure to carbon black nanoparticles and vascular effects.
Topics: Administration, Inhalation; Aging; Animals; Apolipoproteins E; Bronchoalveolar Lavage Fluid; Chemokine CCL2; Heme Oxygenase-1; In Vitro Techniques; Intercellular Adhesion Molecule-1; Lung; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Nanoparticles; Oxidative Stress; Plaque, Atherosclerotic; Pneumonia; Soot; Time Factors; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2010 |
Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury.
Topics: Acute Lung Injury; Animals; Arginine Vasopressin; Cardiac Output; Central Venous Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Oxygen Consumption; Pulmonary Gas Exchange; Random Allocation; Reference Values; Sheep; Sheep, Domestic; Smoke Inhalation Injury; Stroke Volume; Tyrosine; Vascular Resistance; Vasoconstrictor Agents | 2011 |
Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Cesarean Section; Endothelial Cells; Gestational Age; HSP90 Heat-Shock Proteins; Lung; Microtubules; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Premature Birth; Protein Multimerization; Pulmonary Artery; Sepsis; Sheep; Superoxide Dismutase; Superoxides; Tubulin; Tyrosine | 2011 |
Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury.
Topics: Animals; Burns; Capillary Permeability; Catalysis; Disease Models, Animal; Female; Hemodynamics; Interleukin-8; Lung; Metalloporphyrins; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Tyrosine; Vascular Endothelial Growth Factor A | 2011 |
Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice.
Topics: Aldehydes; Animals; Cells, Cultured; Coculture Techniques; Endotoxins; Fatty Liver; Fructokinases; Fructose; Glutathione; I-kappa B Proteins; Insulin Resistance; Kupffer Cells; Lipid Peroxidation; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Toll-Like Receptor 4; Transcription, Genetic; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine; Weight Gain | 2011 |
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Flurbiprofen; Humans; Inflammation; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidoreductases; Parkinson Disease; Rotarod Performance Test; Substantia Nigra; Tyrosine | 2010 |
Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.
Topics: Allopurinol; Animals; Aorta; Arginine; Benzbromarone; Biological Transport; Blood Pressure; Cationic Amino Acid Transporter 1; Disease Models, Animal; Hyperuricemia; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxonic Acid; Phosphorylation; Protein Kinase C-alpha; Rats; Rats, Wistar; Tyrosine; Uric Acid; Uricosuric Agents | 2011 |
Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells.
Topics: Amino Acid Sequence; Animals; Cell Extracts; Chromatography, Liquid; Enzymes; HSP90 Heat-Shock Proteins; Models, Molecular; Molecular Sequence Data; PC12 Cells; Peroxynitrous Acid; Protein Structure, Tertiary; Rats; Tandem Mass Spectrometry; Tryptophan; Tyrosine | 2011 |
Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo.
Topics: Animals; Apoptosis; Cells, Cultured; HMGB1 Protein; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myoblasts, Cardiac; Myocardial Infarction; Necrosis; Peroxynitrous Acid; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Toll-Like Receptor 4; Tyrosine; Up-Regulation | 2011 |
8-oxo-2'-deoxyguanosine suppresses allergy-induced lung tissue remodeling in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Airway Remodeling; Animals; Collagen; Cytokines; Deoxyguanosine; Enzyme Activation; Female; Gene Expression Regulation; Goblet Cells; Hyperplasia; Hypersensitivity; Immunosuppressive Agents; Inflammation; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mucin 5AC; NF-kappa B; rac GTP-Binding Proteins; RNA, Messenger; STAT1 Transcription Factor; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2011 |
Nitrosative protein oxidation is modulated during early endotoxemia.
Topics: Animals; Biotin; Blood Pressure; Cysteine; Endotoxemia; Escherichia coli; Heart; HEK293 Cells; Humans; Hypotension; Immunoblotting; In Vitro Techniques; Lipopolysaccharides; Mass Spectrometry; Metalloporphyrins; Mice; Mice, Inbred C57BL; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Proteins; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sensitivity and Specificity; Sepsis; Signal Transduction; Telemetry; Tyrosine | 2011 |
Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected].
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Catechin; Cell Line; In Situ Nick-End Labeling; Male; Nerve Degeneration; Nerve Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Retina; Retinal Ganglion Cells; RNA, Small Interfering; Tyrosine | 2011 |
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats.
Topics: Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Cytochromes c; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; NADPH Oxidases; Neurologic Examination; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2011 |
Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice.
Topics: Aldehydes; Animals; Blotting, Western; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Transporter 3; Glutathione; Male; Mice; Mice, Knockout; Tyrosine | 2011 |
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome.
Topics: Animals; Aorta; Arginine; Blood Glucose; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fructose; Heart Rate; Hypertension; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2011 |
Effects of cigarette smoke on salivary protein tyrosine nitration.
Topics: Aldehydes; Female; Glutathione; Humans; Male; Nicotiana; Salivary Proteins and Peptides; Smoke; Tyrosine | 2010 |
Changes in nitric oxide, cGMP, and nitrotyrosine concentrations over skin along the meridians in obese subjects.
Topics: Acupuncture Points; Adult; Cyclic GMP; Cyclic N-Oxides; Female; Humans; Imidazoles; Male; Nitrates; Nitric Oxide; Nitrites; Obesity; Skin; Tyrosine | 2011 |
Increased protein nitration in mitochondrial diseases: evidence for vessel wall involvement.
Topics: Adolescent; Adult; Aged; Base Sequence; Brachial Artery; Case-Control Studies; Deafness; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Femoral Artery; Humans; Kearns-Sayre Syndrome; Male; MELAS Syndrome; MERRF Syndrome; Middle Aged; Mitochondrial Diseases; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Point Mutation; Sequence Deletion; Tyrosine; Vasodilation | 2011 |
[Establishment and application of double-antibody sandwich ELISA for determination of 3-nitrotyrosine].
Topics: Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Male; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Rats, Wistar; Sensitivity and Specificity; Tyrosine | 2009 |
The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex.
Topics: Amyloid beta-Peptides; Animals; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Guanidines; Hippocampus; Indazoles; Male; Maze Learning; Memory; Memory Disorders; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Wistar; Temporal Lobe; Tyrosine | 2011 |
Sulfation of chlorotyrosine and nitrotyrosine by human lung endothelial and epithelial cells: role of the human SULT1A3.
Topics: Arylsulfotransferase; Cell Line; Endothelial Cells; Humans; Inflammation Mediators; Lung; Respiratory Mucosa; Sulfates; Sulfotransferases; Tyrosine | 2011 |
Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart.
Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left | 2011 |
Peroxynitrite-induced modification of H2A histone presents epitopes which are strongly bound by human anti-DNA autoantibodies: role of peroxynitrite-modified-H2A in SLE induction and progression.
Topics: Antibodies, Antinuclear; Autoantibodies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Epitopes; Histones; Humans; Lupus Erythematosus, Systemic; Nitro Compounds; Peroxynitrous Acid; Tyrosine | 2011 |
Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amylases; Animals; Apoptosis; Ascitic Fluid; Aspartate Aminotransferases; bcl-2-Associated X Protein; Bicarbonates; Bilirubin; Blood Gas Analysis; Body Weight; Cell Count; Creatinine; Fas Ligand Protein; Hydrogen-Ion Concentration; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1beta; Kidney; Lipase; Liver; Lung; Male; Mice; Mice, Inbred Strains; Multiple Organ Failure; Nitrates; Nitrites; P-Selectin; Pancreas; Phosphodiesterase 3 Inhibitors; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyridones; Survival Analysis; Tumor Necrosis Factor-alpha; Tyrosine; Zymosan | 2011 |
Neurofilament heavy subunit in cerebrospinal fluid: a biomarker of amyotrophic lateral sclerosis?
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Neurofilament Proteins; Neurons; Protein Subunits; Spinal Cord; Tyrosine | 2011 |
Irreversible inflammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts.
Topics: Actins; Adolescent; Adult; CD11b Antigen; CD3 Complex; Dental Caries; Dental Pulp; Dentin; Guanylate Cyclase; Humans; Immunohistochemistry; Inflammation; Inflammation Mediators; Isoenzymes; Microscopy, Confocal; Nitric Oxide Synthase Type II; Odontoblasts; Pulpitis; Reactive Nitrogen Species; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tyrosine; Young Adult | 2011 |
Treatment of diabetic rats with a peroxynitrite decomposition catalyst prevents induction of renal COX-2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Cells, Cultured; Creatinine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Experimental; Dinoprostone; Humans; Kidney; Male; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression.
Topics: Animals; Blood Pressure; Cardiomegaly; Endomyocardial Fibrosis; Male; Mineralocorticoid Receptor Antagonists; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reactive Oxygen Species; Renin-Angiotensin System; Spironolactone; Tyrosine; Vasodilator Agents; Ventricular Dysfunction, Left | 2011 |
Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Astrocytes; Cell Death; Coculture Techniques; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hindlimb; Inflammation; Male; Mice; Mice, Transgenic; Motor Activity; Neurons; Neurotoxins; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2011 |
Effect of exercise on bone and articular cartilage in heterozygous manganese superoxide dismutase (SOD2) deficient mice.
Topics: Animals; Bone and Bones; Cartilage, Articular; Chondrocytes; Dinoprost; Heterozygote; Mice; Mice, Knockout; Osteocytes; Oxidative Stress; Physical Conditioning, Animal; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2011 |
Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress.
Topics: Animals; Betulinic Acid; Brain; Brain Ischemia; Male; Mice; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Pentacyclic Triterpenes; Reactive Nitrogen Species; Reperfusion Injury; RNA, Messenger; Stress, Physiological; Triterpenes; Tyrosine | 2011 |
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Topics: Acetophenones; Allopurinol; Animals; Arrhythmias, Cardiac; Coronary Vessels; Ethidium; Male; Molsidomine; Myocardial Infarction; Myocardium; NADPH Oxidases; Nerve Growth Factor; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Sympathetic Nervous System; Tyrosine; Xanthine Oxidase | 2011 |
Biomarker responses and disease susceptibility in juvenile rainbow trout Oncorhynchus mykiss fed a high molecular weight PAH mixture.
Topics: Aeromonas salmonicida; Animals; Biomarkers; Cytochrome P-450 CYP1A1; Disease Susceptibility; Dose-Response Relationship, Drug; Environmental Monitoring; Epidemiological Monitoring; F2-Isoprostanes; Fish Diseases; Gram-Negative Bacterial Infections; Oncorhynchus mykiss; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; Tyrosine; Water Pollutants, Chemical | 2011 |
A stringent approach to improve the quality of nitrotyrosine peptide identifications.
Topics: Algorithms; Amino Acid Sequence; Computational Biology; Humans; Peptide Mapping; Peptides; Proteomics; Quality Control; Software; Tandem Mass Spectrometry; Tyrosine | 2011 |
Antioxidative properties of curcumin in the protection of blood platelets against oxidative stress in vitro.
Topics: Adult; Antioxidants; Blood Platelets; Curcumin; Humans; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Tyrosine; Young Adult | 2011 |
Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cytokines; Endothelium, Vascular; Forkhead Box Protein O3; Forkhead Transcription Factors; I-kappa B Kinase; Male; Mice; NADPH Oxidases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; Salicylates; Superoxide Dismutase; Tyrosine; Vasodilation | 2011 |
Deleterious effects of intestinal ischemia/reperfusion injury in the mouse enteric nervous system are associated with protein nitrosylation.
Topics: Animals; Apoptosis; Calbindin 2; ELAV Proteins; Enteric Nervous System; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Neurons; Nitric Oxide Synthase; Nitroso Compounds; Reperfusion Injury; S100 Calcium Binding Protein G; Tyrosine | 2011 |
Epitope motif of an anti-nitrotyrosine antibody specific for tyrosine-nitrated peptides revealed by a combination of affinity approaches and mass spectrometry.
Topics: Amino Acid Sequence; Antibodies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Epitopes; Mass Spectrometry; Molecular Sequence Data; Peptides; Tyrosine | 2011 |
Attenuation of brain nitrostative and oxidative damage by brain cooling during experimental traumatic brain injury.
Topics: Animals; Body Temperature; Brain; Brain Infarction; Brain Injuries; Catalase; Glutathione Reductase; Hypothermia, Induced; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Nitrosation; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2011 |
Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma.
Topics: Analysis of Variance; Animals; Burns; Disease Models, Animal; Female; Imidazoles; Immunohistochemistry; Interleukin-8; Lung; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Piperazines; Pulmonary Gas Exchange; Pyrimidines; RNA, Messenger; Sheep; Smoke Inhalation Injury; Tyrosine | 2011 |
Glutamine treatment attenuates the development of organ injury induced by zymosan administration in mice.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Cytokines; Enzyme Activation; Fas Ligand Protein; Gene Expression Regulation; Glutamine; Inflammation; Lipid Peroxidation; Male; Mice; Multiple Organ Failure; Neutrophil Infiltration; Nitric Oxide; Peritoneal Cavity; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Tyrosine; Zymosan | 2011 |
[The correlation of asymmetrical dimethylarginine level and oxidative stress to the onset of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Female; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2010 |
The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets.
Topics: Antioxidants; Blood Platelets; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Humulus; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Phenols; Plant Extracts; Protein Carbonylation; Resveratrol; Stilbenes; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP-Dependent Protein Kinases; Endotoxemia; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Hypotension; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type II; Nitrites; Norepinephrine; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tyrosine | 2011 |
Natural almond skin reduced oxidative stress and inflammation in an experimental model of inflammatory bowel disease.
Topics: Animals; Colitis; Colon; fas Receptor; I-kappa B Proteins; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipid Peroxidation; Male; MAP Kinase Kinase 4; Mice; Neutrophil Infiltration; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Oxidative Stress; P-Selectin; Peroxidase; Phytotherapy; Plant Preparations; Poly(ADP-ribose) Polymerases; Prunus; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Effect of dioxin exposure on several indices of blood redox status in lactating buffalo cows.
Topics: Animals; Antioxidants; Buffaloes; Dioxins; Environmental Exposure; Environmental Pollutants; Female; Lactation; Lipid Peroxides; Oxidation-Reduction; Tyrosine | 2011 |
δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo.
Topics: alpha-Tocopherol; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; DNA Damage; gamma-Tocopherol; Humans; Lung Neoplasms; Male; Mice; Neoplasm Transplantation; Reactive Nitrogen Species; Reactive Oxygen Species; Tocopherols; Tyrosine | 2011 |
High-fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production.
Topics: Adaptation, Physiological; Animals; Diet; Dietary Fats; Energy Intake; Energy Metabolism; Free Radicals; Hydrogen Peroxide; Immunohistochemistry; Inflammation; Kidney; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitochondria; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Reactive Oxygen Species; Subcellular Fractions; Superoxide Dismutase; Tyrosine | 2011 |
Comparison of fluorescence reagents for simultaneous determination of hydroxylated phenylalanine and nitrated tyrosine by high-performance liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Limit of Detection; Peroxynitrous Acid; Phenylalanine; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Fluorescence; Tyrosine | 2012 |
Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Connexin 43; Hyperlipidemias; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Models, Animal; Myocardial Infarction; Rats; Rats, Wistar; Sarcolemma; Superoxides; Tyrosine | 2011 |
Poly(ADP-ribose) polymerase-1: a novel therapeutic target in necrotizing enterocolitis.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Enterocolitis, Necrotizing; Enzyme Activation; Enzyme Inhibitors; Humans; Infant, Newborn; Intestinal Mucosa; Intestines; Niacinamide; Nitric Oxide; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tyrosine | 2011 |
The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Disease Models, Animal; Hydrolysis; Intercellular Adhesion Molecule-1; Interleukin-1beta; Iridoid Glucosides; Iridoids; Lipid Peroxidation; Lung; Male; Mice; Nitric Oxide; Olive Oil; P-Selectin; Phenols; Plant Oils; Pleurisy; Poly Adenosine Diphosphate Ribose; Pyrans; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity.
Topics: Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspase Inhibitors; Cell Cycle Proteins; Eye Diseases; Inflammation; Interleukin-1beta; Male; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Neuroglia; Neuroprotective Agents; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Thioredoxins; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Verapamil | 2011 |
Changes in atherosclerotic plaques induced by inhalation of diesel exhaust.
Topics: Animals; Apolipoproteins E; Cardiovascular Diseases; CD36 Antigens; DNA; Foam Cells; Inhalation Exposure; Macrophages, Alveolar; Male; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Oxidative Stress; Plaque, Atherosclerotic; Risk Factors; Time Factors; Tyrosine; Vehicle Emissions | 2011 |
Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia.
Topics: Adult; Asthma; Chronic Disease; Eosinophils; Female; Humans; Immunohistochemistry; Lung; Macrophages, Alveolar; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Pulmonary Eosinophilia; Tyrosine | 2011 |
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.
Topics: Aging; Animals; Blotting, Western; Carbonic Anhydrase III; Electric Stimulation; Ethidium; Fluoresceins; Fluorescence; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxiredoxins; Peroxynitrous Acid; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tyrosine | 2011 |
Diabetic Retinopathy Is Associated with Decreased Tyrosine Nitrosylation of Vitreous Interleukins IL-1α, IL-1β, and IL-7.
Topics: Aged; Blood Glucose; Blotting, Western; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycated Hemoglobin; Humans; Immunoprecipitation; Interleukin-1alpha; Interleukin-1beta; Interleukin-7; Male; Middle Aged; Nitric Oxide; Phosphorylation; Phosphotyrosine; Tyrosine; Vitreous Body | 2011 |
Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.
Topics: Alzheimer Disease; Brain; Cell Line; Citric Acid Cycle; Enzyme Activation; Humans; Ketoglutarate Dehydrogenase Complex; Mitochondria; Mitochondrial Proteins; Peroxynitrous Acid; Tyrosine | 2011 |
Clovamide-rich extract from Trifolium pallidum reduces oxidative stress-induced damage to blood platelets and plasma.
Topics: Adult; Blood Platelets; Blood Proteins; Humans; Lipids; Oxidative Stress; Peroxynitrous Acid; Plant Components, Aerial; Plant Extracts; Plasma; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Trifolium; Tyrosine; Young Adult | 2011 |
Characterization of tyrosine nitration and cysteine nitrosylation modifications by metastable atom-activation dissociation mass spectrometry.
Topics: Amino Acid Sequence; Biochemical Phenomena; Cysteine; Mass Spectrometry; Nitro Compounds; Peptides; Sequence Analysis, Protein; Tyrosine | 2011 |
Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis.
Topics: Adrenomedullin; Animals; Anti-Inflammatory Agents; Bleomycin; Cell Adhesion Molecules; Cytokines; Disease Models, Animal; Inflammation Mediators; Injections, Intraperitoneal; Lung; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Peroxidase; Pneumonia; Poly(ADP-ribose) Polymerases; Pulmonary Fibrosis; Severity of Illness Index; Time Factors; Transforming Growth Factor beta; Tyrosine | 2011 |
Formation of 3-nitrotyrosine by riboflavin photosensitized oxidation of tyrosine in the presence of nitrite.
Topics: Animals; Cattle; Nitrites; Oxidation-Reduction; Photosensitivity Disorders; Riboflavin; Serum Albumin; Sunlight; Tyrosine | 2012 |
Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Blotting, Western; Brain; Cerebellum; Cognitive Dysfunction; Female; Heme Oxygenase (Decyclizing); Hippocampus; Homeostasis; Humans; Immunoprecipitation; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; Protein Carbonylation; Reactive Nitrogen Species; Tyrosine | 2011 |
8-hydroxydeguanosine and nitrotyrosine are prognostic factors in urinary bladder carcinoma.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers, Tumor; Carcinoma; Cell Nucleus; Cytoplasm; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oxidative Stress; Peroxiredoxins; Prognosis; Statistics, Nonparametric; Thioredoxins; Tyrosine; Urinary Bladder Neoplasms | 2011 |
Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria.
Topics: Animals; Antioxidants; Caspase 3; Cell Line; Clone Cells; Cytokines; Enzyme Inhibitors; Fluoresceins; Hydrogen Peroxide; Hydroxyl Radical; Insulin; Insulin-Secreting Cells; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Tyrosine | 2011 |
Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats.
Topics: Animals; Azepines; Biomarkers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Male; Mesenteric Arteries; Molsidomine; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Tyrosine; Vascular System Injuries | 2011 |
Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes.
Topics: Adult; Albuminuria; Blood Glucose; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Nitroglycerin; Oxidative Stress; Regional Blood Flow; Tyrosine; Ultrasonography; Vasodilation; Vasodilator Agents | 2011 |
Resveratrol preserves cardiac function, but does not prevent endothelial dysfunction or pulmonary inflammation after environmental tobacco smoke exposure.
Topics: Administration, Oral; Animals; Aorta, Abdominal; Blood Pressure; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Cardiovascular Physiological Phenomena; Cotinine; Cytochrome P-450 CYP1A1; Echocardiography; Endothelium, Vascular; Environmental Exposure; Leukocyte Count; Leukocyte Elastase; Male; Nitrates; Nitrites; Oxidative Stress; Resveratrol; Stilbenes; Swine; Tobacco Smoke Pollution; Tyrosine; Ventricular Function, Left | 2011 |
Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cerebral Infarction; Disease Models, Animal; Diterpenes; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Male; Mice; Mice, Inbred ICR; Microglia; NADPH Oxidases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrosation; Phosphatidylinositol 3-Kinase; Reactive Oxygen Species; Stroke; Superoxides; Tyrosine; Up-Regulation | 2011 |
Confident identification of 3-nitrotyrosine modifications in mass spectral data across multiple mass spectrometry platforms.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, Liquid; Complex Mixtures; Data Interpretation, Statistical; Drug Stability; Humans; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Protein Processing, Post-Translational; Proteomics; Serum Albumin, Bovine; Tyrosine | 2011 |
Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation.
Topics: Animals; Antioxidants; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Flavanones; Gene Expression Regulation; Hyperalgesia; Mice; Mice, Inbred C57BL; Neural Conduction; Oligonucleotides, Antisense; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reaction Time; Receptors, Eicosanoid; Sciatic Nerve; Spinal Cord; Statistics, Nonparametric; Tyrosine | 2011 |
L-NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation.
Topics: alpha-Synuclein; Animals; Anxiety Disorders; Behavior, Animal; Central Nervous System; Dietary Supplements; Diterpenes; Electron Transport; Glutathione Transferase; Heat-Shock Proteins; Illness Behavior; Locomotion; Male; Manganese; Mitochondria; Monoamine Oxidase; Neurodegenerative Diseases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Dopamine; Receptors, Immunologic; Retinyl Esters; Superoxide Dismutase; Superoxides; Tyrosine; Vitamin A | 2012 |
MEK inhibition suppresses the development of lung fibrosis in the bleomycin model.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bleomycin; Body Weight; Butadienes; Fas Ligand Protein; Flavonoids; I-kappa B Proteins; Instillation, Drug; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lung; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Neutrophils; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Nitriles; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pulmonary Edema; Pulmonary Fibrosis; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
The short-term consumption of a moderately high-fat diet alters nitric oxide bioavailability in lean female Zucker rats.
Topics: Animals; Biological Availability; Diet; Dietary Fats; Drinking; Eating; Female; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Rats, Zucker; Reactive Oxygen Species; Tissue Distribution; Tyrosine | 2011 |
Selective chemoprecipitation and subsequent release of tagged species for the analysis of nitropeptides by liquid chromatography-tandem mass spectrometry.
Topics: Amino Acid Sequence; Blood Proteins; Chemical Precipitation; Chromatography, Liquid; Humans; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Processing, Post-Translational; Proteolysis; Reference Standards; Staining and Labeling; Tandem Mass Spectrometry; Tyrosine | 2011 |
Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes.
Topics: Alanine Transaminase; Aldehydes; Animals; Anti-Inflammatory Agents; Fatty Liver; Inflammation; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; NADPH Oxidases; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Peroxidase; Plant Extracts; Reactive Oxygen Species; Stress, Physiological; Tea; Tyrosine | 2012 |
Post-ischemic early acidosis in cardiac postconditioning modifies the activity of antioxidant enzymes, reduces nitration, and favors protein S-nitrosylation.
Topics: Acidosis; Animals; Catalase; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine | 2011 |
Hypertonic saline and reduced peroxynitrite formation in experimental pancreatitis.
Topics: Alanine Transaminase; Animals; Blotting, Western; Gene Expression; Lipid Peroxidation; Liver; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Pancreatitis; Peroxynitrous Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Saline Solution, Hypertonic; Time Factors; Tyrosine | 2011 |
Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice.
Topics: Animals; Biopterins; Cardiotonic Agents; Coenzymes; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Enzyme Inhibitors; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Pterins; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left | 2011 |
Generation of novel recombinant antibodies against nitrotyrosine by antibody phage display.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Antigens; Binding Sites; Biotinylation; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Immunoconjugates; Mice; Molecular Sequence Data; Peptide Library; Peroxynitrous Acid; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; Small Molecule Libraries; Tyrosine | 2011 |
Effects of oral administration of (L)-arginine, (L)-NAME and allopurinol on intestinal ischemia/reperfusion injury in rats.
Topics: Administration, Oral; Allopurinol; Animals; Arginine; Catalase; Intestines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Time Factors; Tyrosine | 2011 |
Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antioxidants; Cell Proliferation; Culture Media; Deoxyguanosine; Diabetes Complications; DNA Damage; Fibroblasts; Glucose; Glutathione; Humans; Hydrogen; Malondialdehyde; Mannitol; Oxidative Stress; Reactive Oxygen Species; Skin; Skin Diseases; Superoxide Dismutase; Tyrosine | 2011 |
Immunolocalization of protein-bound 3-nitrotyrosine in inflammatory myopathies.
Topics: Adult; Aged; Dermatomyositis; Endothelium; Female; Humans; Immunohistochemistry; Male; Middle Aged; Muscle, Skeletal; Myositis; Polymyositis; Protein Binding; Tyrosine | 2011 |
Soft tissue response to titanium dioxide nanotube modified implants.
Topics: Animals; Cell Count; Fibrosis; Implants, Experimental; Macrophages; Male; Nanotubes; Nitric Oxide; Organ Specificity; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Surface Properties; Titanium; Tyrosine | 2011 |
Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice.
Topics: Adiponectin; Analysis of Variance; Animals; Aorta; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Inflammation Mediators; Interferon-gamma; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Physical Exertion; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2011 |
Ischemia-induced nitrotyrosine formation and nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in human retinal pigment epithelium in vivo.
Topics: Aged; Apoptosis; Cell Line; Cell Nucleus; Choroid; Epithelial Cells; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Ischemia; Oxidative Stress; Protein Transport; Retinal Pigment Epithelium; Tyrosine | 2011 |
Altered regulation of renal nitric oxide and atrial natriuretic peptide systems in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Hypertension; Kidney; Kidney Function Tests; Male; Neprilysin; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Tyrosine | 2011 |
Telmisartan provides protection against development of impaired vasodilation independently of metabolic effects in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood; Blood Glucose; Blood Pressure; Cholesterol; Crosses, Genetic; Guanylate Cyclase; Hypoglycemic Agents; Insulin; Male; Mesenteric Arteries; Metabolic Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Telmisartan; Thiazolidinediones; Triglycerides; Tyrosine; Vasoconstriction; Vasodilation | 2011 |
Glabridin protects osteoblastic MC3T3-E1 cells against antimycin A induced cytotoxicity.
Topics: Animals; Antimycin A; Calcium; Cell Line; CREB-Binding Protein; Cytochromes c; Isoflavones; Mice; Osteoblasts; Oxidative Stress; Phenols; Phosphatidylinositol 3-Kinases; Phosphorylation; Reactive Oxygen Species; Thioredoxin-Disulfide Reductase; Tyrosine | 2011 |
High glucose induced rat aorta vascular smooth muscle cell oxidative injury: involvement of protein tyrosine nitration.
Topics: Animals; Aorta; Cell Survival; Glucose; Glucose Oxidase; Glutathione; Hemin; Lipid Peroxidation; Male; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Primary Cell Culture; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2011 |
Nitration activates tyrosine toward reaction with the hydrated electron.
Topics: Absorption; Electrons; Kinetics; Oligopeptides; Pulse Radiolysis; Spectrum Analysis; Tyrosine | 2011 |
Effect of N-nitrosodimethylamine on inducible nitric oxide synthase expression and production of nitric oxide by neutrophils and mononuclear cells: the role of JNK signalling pathway.
Topics: Adult; Cells, Cultured; Dimethylnitrosamine; Humans; JNK Mitogen-Activated Protein Kinases; Leukocytes, Mononuclear; MAP Kinase Signaling System; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Superoxides; Tyrosine | 2011 |
Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass.
Topics: Aged; Antioxidants; beta Carotene; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Female; Free Radicals; Humans; Hydrogen Peroxide; Male; Middle Aged; Myocardial Reperfusion Injury; Nitric Oxide; Oxidative Stress; Protein Carbonylation; Tyrosine; Vitamin E | 2011 |
Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Drinking; Eating; Endothelium, Vascular; Heart; Hypertension; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Organ Size; Oxidative Stress; Rats; Rats, Inbred SHR; Resveratrol; Stilbenes; Tyrosine | 2011 |
Smoking, COPD, and 3-nitrotyrosine levels of plasma proteins.
Topics: Adult; Aged; Analysis of Variance; Blood Proteins; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Humans; Middle Aged; Nitric Oxide; Pulmonary Disease, Chronic Obstructive; Smoking; Tyrosine; Utah; Young Adult | 2011 |
Cyclic adenosine 3',5'-monophosphate in rat steatotic liver transplantation.
Topics: Animals; Cyclic AMP; Fatty Liver; Homozygote; Hyaluronic Acid; Ischemia; Ischemic Preconditioning; Liver; Liver Transplantation; Oxidative Stress; Rats; Rats, Zucker; Time Factors; Transaminases; Tyrosine | 2011 |
Synthesis of molecularly imprinted polymers for amino acid derivates by using different functional monomers.
Topics: Acrylamides; Acrylates; Amino Acids; Kinetics; Methacrylates; Molecular Imprinting; Polymers; Pyridines; Tyrosine | 2011 |
Effects of taurine on nitric oxide and 3-nitrotyrosine levels in spleen during endotoxemia.
Topics: Animals; Antioxidants; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Male; Nitric Oxide; Spleen; Taurine; Tyrosine | 2011 |
High temperature triggers the metabolism of S-nitrosothiols in sunflower mediating a process of nitrosative stress which provokes the inhibition of ferredoxin-NADP reductase by tyrosine nitration.
Topics: Aldehyde Oxidoreductases; Arginine; Ferredoxin-NADP Reductase; Gene Expression Regulation, Plant; Helianthus; Hot Temperature; Hypocotyl; Lipid Peroxides; Nitrate Reductase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrosation; Peroxynitrous Acid; Photosynthesis; Proteomics; S-Nitrosoglutathione; S-Nitrosothiols; Stress, Physiological; Superoxides; Tyrosine | 2011 |
Increase of nitrosative stress in patients with eosinophilic pneumonia.
Topics: Adrenal Cortex Hormones; Aged; Analysis of Variance; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Exhalation; Female; Humans; Idiopathic Pulmonary Fibrosis; Immunohistochemistry; Inflammation Mediators; Japan; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Pulmonary Alveoli; Pulmonary Eosinophilia; Respiratory Function Tests; Stress, Physiological; Time Factors; Treatment Outcome; Tyrosine; Up-Regulation | 2011 |
Loxin polymorphism is associated with increased resistin levels and with oxidative status.
Topics: Antioxidants; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Cohort Studies; Cytokines; Gene Frequency; Homozygote; Humans; Inflammation; Lipid Metabolism; Lipoproteins, LDL; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Resistin; Scavenger Receptors, Class E; Triglycerides; Tyrosine | 2011 |
Trypanosoma evansi: concentration of 3-nitrotyrosine in the brain of infected rats.
Topics: Animals; Brain; Case-Control Studies; Cerebellum; Cerebral Cortex; Corpus Striatum; Dogs; Hippocampus; Parasitemia; Rats; Rats, Wistar; Trypanosomiasis; Tyrosine | 2011 |
NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species.
Topics: Acetophenones; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Gene Expression; Ischemia; Membrane Glycoproteins; Microscopy, Immunoelectron; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Nuclear Pore; Onium Compounds; Rats; Reactive Oxygen Species; Signal Transduction; Sodium Cyanide; Tyrosine | 2011 |
Protective effect of diazoxide against antimycin A-induced mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.
Topics: Animals; Antimycin A; Calcium; Cell Line; Cell Survival; Diazoxide; Electron Transport Complex IV; Membrane Potential, Mitochondrial; Mice; Mitochondria; Osteoblasts; Oxidative Stress; Protective Agents; Superoxides; Thioredoxin-Disulfide Reductase; Tyrosine | 2011 |
Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats.
Topics: Acute Disease; Alanine Transaminase; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 8; Female; Gene Expression Regulation; Hemorrhage; Inflammation; Interleukin-6; L-Lactate Dehydrogenase; Liver; NF-kappa B; Oxidative Stress; Plant Extracts; Polyphenols; Rats; Rats, Inbred Lew; Resuscitation; RNA; Tea; Tyrosine | 2012 |
Role of oxidative/nitrative stress in hepatic encephalopathy induced by thioacetamide.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Hepatic Encephalopathy; Liver; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Spectrometry, Fluorescence; Stress, Physiological; Superoxide Dismutase; Superoxides; Thioacetamide; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion?
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels; Dogs; Female; Heart Ventricles; Hemodynamics; Hydrogen-Ion Concentration; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Nitrates; Nitrites; Peroxynitrous Acid; Superoxides; Time Factors; Tyrosine; Uric Acid | 2011 |
Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Cerium; Disease Models, Animal; Free Radical Scavengers; Hippocampus; Mice; Nanoparticles; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine | 2011 |
Identification of tyrosine nitration in UCH-L1 and GAPDH.
Topics: Amino Acid Sequence; Animals; Brain; Brain Chemistry; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Immunoblotting; Male; Molecular Sequence Data; Nitrosation; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Rabbits; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tobacco Smoke Pollution; Tyrosine; Ubiquitin Thiolesterase | 2011 |
Impairment of adult hippocampal neural progenitor proliferation by methamphetamine: role for nitrotyrosination.
Topics: Animals; Antioxidants; Apoptosis; Cell Differentiation; Cell Proliferation; Chromans; Dopamine Agents; Hippocampus; Humans; Methamphetamine; Models, Molecular; Neural Stem Cells; Oxidative Stress; Protein Conformation; Pyruvate Kinase; Rats; Rats, Inbred F344; Substance-Related Disorders; Tyrosine | 2011 |
Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress.
Topics: Aged; Aldehydes; Analysis of Variance; Female; Histological Techniques; Humans; Immunohistochemistry; Male; Mammary Arteries; Middle Aged; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Spasm; Tyrosine; Vascular Grafting; Vasomotor System | 2011 |
Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen.
Topics: Animals; Brain; Cyclooxygenase Inhibitors; Cytokines; Cytoprotection; Dinoprostone; Flurbiprofen; Hypoxia, Brain; Ibuprofen; In Vitro Techniques; Lipid Peroxidation; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stereoisomerism; Tyrosine | 2011 |
Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice.
Topics: Amidines; Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Benzylamines; CD36 Antigens; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Male; Mice; Mice, Knockout; Myocardium; NF-kappa B; Nitric Oxide Synthase Type II; Particulate Matter; RNA, Messenger; Tyrosine; Up-Regulation; Vasoconstriction; Vehicle Emissions | 2011 |
Anti-inflammatory effect of the epigallocatechin gallate following spinal cord trauma in rat.
Topics: Animals; Anti-Inflammatory Agents; Catechin; Cyclooxygenase 2; Densitometry; Immunohistochemistry; Interleukin-1beta; Male; Myelin Sheath; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Peroxidase; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
1α,25(OH)₂-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Calcitriol; Carcinoma, Squamous Cell; Cell Line; Humans; Immunosuppressive Agents; Mice; Receptors, Calcitriol; Signal Transduction; Skin Neoplasms; Tumor Suppressor Protein p53; Tyrosine; Ultraviolet Rays | 2011 |
A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death.
Topics: alpha-Synuclein; Antibodies; Apoptosis; Calcium; Caspase 3; Cell Line, Tumor; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Integrin alpha5beta1; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Polymerization; Recombinant Proteins; Signal Transduction; Tyrosine | 2011 |
Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox).
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Cell Membrane; Cell Nucleus; Cell Survival; Extracellular Space; Homocysteine; Intracellular Space; Membrane Glycoproteins; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Phospholipid Transfer Proteins; Rats; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine; Tyrosine | 2011 |
CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Animals; bcl-2-Associated X Protein; Carrageenan; Cytokines; Enzyme Activation; Fas Ligand Protein; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Mice; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide Synthase Type II; Nitrites; P-Selectin; Peroxidase; Phenethylamines; Pleurisy; Pneumonia; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Receptor, Adenosine A2A; Transcription Factor RelA; Tyrosine | 2011 |
Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium-Dependent Relaxing Factors; Free Radical Scavengers; Hypertrophy, Right Ventricular; Hypocapnia; Hypoxia; Ionomycin; Lung; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Polycythemia; Pulmonary Artery; Rats; Rats, Wistar; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxides; Tyrosine; Vasodilation | 2011 |
Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.
Topics: Aged; alpha-Synuclein; Biomarkers; Colon; Enteric Nervous System; Female; Humans; Male; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Substantia Nigra; Tyrosine | 2012 |
Lipopolysaccharide-induced mitochondrial DNA depletion.
Topics: Aconitate Hydratase; Adenosine Triphosphate; Alanine Transaminase; Animals; ATP Synthetase Complexes; DNA-Binding Proteins; DNA, Mitochondrial; Electron Transport Complex I; Electron Transport Complex III; Electron Transport Complex IV; Hep G2 Cells; High Mobility Group Proteins; Humans; Interferon-beta; Iron; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Reactive Oxygen Species; Sepsis; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Toll-Like Receptor 4; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids.
Topics: Amino Acid Substitution; Amino Acids; Animals; Autoantibodies; CD4-Positive T-Lymphocytes; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epitopes; Female; Immune Tolerance; Immunization; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mutant Proteins; Phenylalanine; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage.
Topics: Aldehydes; Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Electroretinography; Enzyme-Linked Immunosorbent Assay; Light; Male; Oxidative Stress; Rats; Rats, Wistar; Retina; Sulfonamides; Thioredoxins; Tyrosine | 2011 |
Luteolin protects osteoblastic MC3T3-E1 cells from antimycin A-induced cytotoxicity through the improved mitochondrial function and activation of PI3K/Akt/CREB.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Calcium; Cardiolipins; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein; Cytochromes c; Luteolin; Membrane Potential, Mitochondrial; Mice; Mitochondria; NADP; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Protective Agents; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Thioredoxin-Disulfide Reductase; Tyrosine | 2011 |
Administration of carnosine in the treatment of acute spinal cord injury.
Topics: Animals; bcl-2-Associated X Protein; Carnosine; Dose-Response Relationship, Drug; Fas Ligand Protein; Gene Expression Regulation; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Tyrosine | 2011 |
Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis.
Topics: Analgesics; Animals; Antioxidants; Bone Resorption; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Iodoacetates; Knee Joint; Male; Matrix Metalloproteinase 13; Osteoarthritis; Pain; Plant Extracts; Proanthocyanidins; Rats; Rats, Wistar; Seeds; Tomography, Emission-Computed; Tyrosine; Vitis | 2011 |
Effect of taurine on brain 8-hydroxydeoxyguanosine and 3-nitrotyrosine levels in endotoxemia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Brain; Deoxyguanosine; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Male; Oxidative Stress; Random Allocation; Taurine; Tyrosine | 2012 |
Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Brain; Calcium Channel Blockers; Calcium Channels; Carotid Arteries; Drug Therapy, Combination; Endothelial Cells; Hypertension; Hypoxia-Ischemia, Brain; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Tetrazoles; Tyrosine; Valine; Valsartan | 2011 |
Effect of treatment of high fat fed/low dose streptozotocin-diabetic rats with Ilepatril on vascular and neural complications.
Topics: Adipose Tissue; Animals; Arterioles; Blood Glucose; Blood Vessels; Body Weight; Carbohydrate Metabolism; Diabetes Complications; Diabetes Mellitus, Experimental; Diet, High-Fat; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose Tolerance Test; Glutathione; Heterocyclic Compounds, 3-Ring; Insulin; Lens, Crystalline; Leptin; Male; Muscle, Skeletal; Nerve Fibers; Nervous System; Nociception; Organ Size; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Superoxides; Thiobarbiturates; Tyrosine; Vasodilation | 2011 |
Distinct cardiac and renal effects of ETA receptor antagonist and ACE inhibitor in experimental type 2 diabetes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Body Weight; Cell Count; Collagen Type III; Diabetes Mellitus, Type 2; Endothelin A Receptor Antagonists; Endothelin-1; Heart; Hemodynamics; Immunohistochemistry; Kidney; Kidney Function Tests; Male; Muscle Cells; Myocardium; Rats; Rats, Zucker; Real-Time Polymerase Chain Reaction; Receptors, Vascular Endothelial Growth Factor; Survival; Tyrosine; Vascular Endothelial Growth Factor A | 2011 |
Investigating the effect of antioxidant treatment on the protective effect of preconditioning in anesthetized rabbits.
Topics: Animals; Antioxidants; Glutathione; Infusions, Intravenous; Ischemic Preconditioning, Myocardial; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Myocardial Infarction; Oxidative Stress; Rabbits; Time Factors; Tiopronin; Tyrosine | 2011 |
Protective effects of catalase on retinal ischemia/reperfusion injury in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Catalase; Cell Count; Cell Survival; Deoxyguanosine; Dependovirus; Electroretinography; Enzyme-Linked Immunosorbent Assay; Female; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Malondialdehyde; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells; Tyrosine | 2011 |
Interplay of endothelial and inducible nitric oxide synthases modulates the vascular response to ischaemia-reperfusion in the rabbit lung.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Lung; NADPH Oxidases; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphorylation; Pulmonary Artery; Pulmonary Circulation; Rabbits; Reactive Nitrogen Species; Reperfusion Injury; Respiration, Artificial; Time Factors; Tyrosine; Vascular Resistance; Vasoconstriction | 2012 |
Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage.
Topics: Adult; Blood Flow Velocity; Blood-Brain Barrier; Cerebrovascular Circulation; Electron Spin Resonance Spectroscopy; Exercise; Free Radicals; Homeostasis; Humans; Male; Middle Cerebral Artery; Nerve Growth Factors; Nitric Oxide; Oxidative Stress; Permeability; Phosphopyruvate Hydratase; Pyrroles; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine | 2011 |
[Role of mitochondria and reactive oxygen species in the progression of heart failure].
Topics: Adult; Case-Control Studies; Disease Progression; Female; Heart Failure; Humans; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Mitochondria, Heart; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Severity of Illness Index; Tyrosine | 2010 |
Effects of human endothelial gene polymorphisms on cellular responses to hyperglycaemia: role of NOS3 (Glu298Asp) and ACE (I/D) polymorphisms.
Topics: Caveolin 1; Cell Death; Cells, Cultured; Diabetic Angiopathies; Genotype; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Nitric Oxide Synthase Type III; Nitrites; Peptidyl-Dipeptidase A; Phenotype; Phosphorylation; Polymorphism, Genetic; Proto-Oncogene Proteins c-akt; Tyrosine | 2011 |
Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents.
Topics: Animals; Cell Death; Cell Proliferation; Enzyme Inhibitors; Guanidines; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Ki-67 Antigen; Male; Methotrexate; Mice; Mice, Knockout; Mucositis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Tyrosine | 2011 |
Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats.
Topics: Animals; Antioxidants; Boranes; Carbon Monoxide; Carbonates; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hemodynamics; Kidney; Male; Metalloporphyrins; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Circulation; Spin Labels; Time Factors; Tyrosine; Vasoconstriction; Vasodilation | 2011 |
Increased 3-nitrotyrosine levels in mitochondrial membranes and impaired respiratory chain activity in brain regions of adult female rats submitted to daily vitamin A supplementation for 2 months.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Brain Chemistry; Electron Transport; Enzyme-Linked Immunosorbent Assay; Estrous Cycle; Female; Glycation End Products, Advanced; Mitochondrial Diseases; Mitochondrial Membranes; Monoamine Oxidase; Oxidative Stress; Rats; Rats, Wistar; Receptors, Dopamine D2; Succinate Dehydrogenase; Superoxide Dismutase; Synucleins; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquinone; Vitamin A; Vitamins | 2011 |
Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain.
Topics: Animals; Benzopyrans; Blotting, Western; Brain Injuries; Fibrinolytic Agents; Ischemic Attack, Transient; Male; Matrix Metalloproteinase 9; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Stachybotrys; Superoxides; Tyrosine | 2011 |
Increased calcification and protein nitration in arteries of chronic kidney disease patients.
Topics: Adult; Atherosclerosis; Case-Control Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Proteins; Renal Artery; Risk Factors; Tyrosine; Vascular Calcification | 2011 |
Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction.
Topics: Administration, Oral; Angiogenesis Inducing Agents; Animals; Biopterins; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; GTP Cyclohydrolase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pterins; Recovery of Function; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Ventricular Function, Left | 2011 |
Protein tyrosine nitration in the cell cycle.
Topics: Cell Cycle; Cell Line, Tumor; G1 Phase; Humans; Nitrates; Protein Processing, Post-Translational; Proteins; Resting Phase, Cell Cycle; Tyrosine | 2011 |
Aminoguanidine, a selective nitric oxide synthase inhibitor, attenuates cyclophosphamide-induced renal damage by inhibiting protein nitration and poly(ADP-Ribose) polymerase activation.
Topics: Animals; Cyclophosphamide; Enzyme Activation; Enzyme Inhibitors; Guanidines; Kidney; Male; Nitrates; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine | 2011 |
Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite.
Topics: Animals; Anticarcinogenic Agents; Burkitt Lymphoma; Cell Line, Tumor; Female; Free Radical Scavengers; Humans; Mice; Mice, Inbred ICR; Pancreatic Neoplasms; Papilloma; Peroxynitrous Acid; Skin Neoplasms; Tyrosine; Xanthophylls | 2011 |
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Biophysics; Brain; Disease Models, Animal; Drug Combinations; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Nitric Oxide Synthase Type II; Patch-Clamp Techniques; Peptide Fragments; Peroxynitrous Acid; Plaque, Amyloid; Presenilin-1; Tyrosine | 2011 |
SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Aniline Compounds; Animals; Brain; Calcium-Binding Proteins; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Gene Expression Regulation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Phenyl Ethers; Phosphorylation; Rotarod Performance Test; Sodium-Calcium Exchanger; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase | 2011 |
Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia.
Topics: Animals; Blotting, Western; Dose-Response Relationship, Drug; Hypoxia-Ischemia, Brain; Male; Membrane Glycoproteins; Mice; Mice, Inbred ICR; NADPH Oxidase 2; NADPH Oxidases; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosation; Oxidative Stress; Prodigiosin; Reactive Oxygen Species; Tyrosine | 2011 |
Expression and prognostic evaluation of oxidative stress markers in an immunohistochemical study of B-cell derived lymphomas.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers, Tumor; Deoxyguanosine; Disease-Free Survival; Female; Glutamate-Cysteine Ligase; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymph Nodes; Lymphoma, B-Cell; Male; Middle Aged; Oxidative Stress; Prognosis; Reproducibility of Results; Sensitivity and Specificity; Superoxide Dismutase; Thioredoxins; Tyrosine | 2012 |
Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress.
Topics: Adult; Aging; Brachial Artery; Cardiovascular Diseases; Endothelial Cells; Endothelium, Vascular; Exercise; Gene Expression; Humans; Male; Middle Aged; NADPH Oxidases; Oxidative Stress; Oxygen Consumption; Risk Factors; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Vasodilation | 2011 |
Adiponectin protects endothelial cells from the damages induced by the intermittent high level of glucose.
Topics: Adiponectin; Analysis of Variance; Apoptosis; Caspase 3; Cells, Cultured; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide; Oxidative Stress; Protein Folding; Second Messenger Systems; Signal Transduction; Tyrosine | 2011 |
Therapeutic effects of four molecular-weight fractions of Kurozu against dextran sulfate sodium-induced experimental colitis.
Topics: Acetic Acid; Animals; Body Weight; Colitis; Colon; Dextran Sulfate; Female; Mice; Mice, Inbred C57BL; Molecular Weight; Occult Blood; Oryza; Oxidative Stress; Tyrosine | 2011 |
[Oxidative stress in soleus and extensor digitorum longus (EDL) muscles of spontaneously hypertensive rats].
Topics: Animals; Endothelium, Vascular; Hypertension; Male; Muscle, Skeletal; Myositis; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Identification of nitrotyrosine containing peptides using combined fractional diagonal chromatography (COFRADIC) and off-line nano-LC-MALDI.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Cytochromes c; Molecular Sequence Data; Nanotechnology; Nitrosation; Peptide Fragments; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2011 |
Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Biomarkers; Case-Control Studies; Cholagogues and Choleretics; Female; Humans; Keratin-18; Liver Cirrhosis, Biliary; Male; Middle Aged; Nitroso Compounds; Oxidation-Reduction; Oxidative Stress; Thioredoxins; Tyrosine; Ursodeoxycholic Acid | 2011 |
Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
Topics: Animals; Antioxidants; Aorta; Biopterins; Catalase; Cyclic GMP; GTP Cyclohydrolase; Hydrogen Peroxide; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Serine; Superoxide Dismutase; Superoxides; Tyrosine | 2011 |
Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.
Topics: Aging; Animals; Aorta; Chronic Disease; Hydrogen Peroxide; Kidney; Kidney Diseases; Male; NADPH Oxidases; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Superoxide Dismutase; Tyrosine | 2011 |
Competitive, non-competitive, and mixed format cleavable tag immunoassays.
Topics: Antibodies; Avidin; Binding, Competitive; Biomarkers; C-Reactive Protein; Electrophoresis, Capillary; Fluorescence; Fluorescent Dyes; Immunoassay; Inflammation; Limit of Detection; Microscopy, Fluorescence; Reactive Nitrogen Species; Reference Standards; Thyroxine; Tyrosine | 2012 |
Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.
Topics: Acetyl-CoA Carboxylase; Aldehydes; AMP-Activated Protein Kinases; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Berberine; Blood Glucose; Cholesterol; Enzyme Activation; Humans; Intercellular Adhesion Molecule-1; Ion Channels; Mice; Mitochondrial Proteins; Phosphorylation; Plaque, Atherosclerotic; Protein Transport; Serine; Threonine; Transcription, Genetic; Triglycerides; Tyrosine; Uncoupling Protein 2; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2011 |
Biphasic stress response in the soleus during reloading after hind limb unloading.
Topics: Animals; DNA-Binding Proteins; Heat Shock Transcription Factors; Hindlimb Suspension; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Insulin-Like Growth Factor I; Male; Muscle, Skeletal; Muscular Atrophy; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Stress, Physiological; Transcription Factors; Tyrosine | 2012 |
Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway.
Topics: Animals; Apoptosis; Cell Nucleus; Cell Survival; Gene Expression Regulation, Enzymologic; Glucosides; Intracellular Space; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidopamine; PC12 Cells; Rats; Reactive Oxygen Species; Signal Transduction; Stilbenes; Tyrosine | 2011 |
Fe allocation in liver during early stages of endotoxemia in Fe-overload rats.
Topics: Analysis of Variance; Animals; Endotoxemia; Ferritins; Hemoglobins; Iron; Iron Overload; Iron-Dextran Complex; Lipopolysaccharides; Liver; Male; Nitric Oxide; Protein Carbonylation; Rats; Rats, Wistar; Tyrosine | 2011 |
Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.
Topics: Adolescent; Adult; Age Factors; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Down Syndrome; Female; Frontal Lobe; Humans; Male; Middle Aged; Nitrosation; Oxidation-Reduction; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2012 |
Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes.
Topics: Animals; Antioxidants; Apoptosis; Blood-Retinal Barrier; Cells, Cultured; Cyclic N-Oxides; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Intramolecular Oxidoreductases; Lipoproteins, LDL; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Pericytes; Receptors, Thromboxane; Retina; Spin Labels; Superoxide Dismutase; Tight Junctions; Tyrosine | 2011 |
Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Hydrogen; Lipopolysaccharides; Male; Malondialdehyde; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Peroxidase; Pulmonary Edema; Superoxide Dismutase; Treatment Outcome; Tyrosine | 2011 |
Maternal thimerosal exposure results in aberrant cerebellar oxidative stress, thyroid hormone metabolism, and motor behavior in rat pups; sex- and strain-dependent effects.
Topics: Animals; Animals, Newborn; Cerebellum; Female; Gene Expression; Iodide Peroxidase; Learning; Male; Mice; Motor Activity; Motor Skills; Nervous System; Oxidative Stress; Pregnancy; Preservatives, Pharmaceutical; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Sex Characteristics; Species Specificity; Stem Cells; Thimerosal; Thyroid Hormones; Triiodothyronine; Tyrosine | 2012 |
Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosis.
Topics: Adult; Blood Proteins; Blood-Brain Barrier; Carbon; Disease Progression; Female; Humans; Male; Middle Aged; Models, Statistical; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Oxidative Stress; Oxygen; Reactive Oxygen Species; Tyrosine; Uric Acid | 2012 |
A lipophilic nitric oxide donor and a lipophilic antioxidant compound protect rat heart against ischemia-reperfusion injury if given as hybrid molecule but not as a mixture.
Topics: Animals; Antioxidants; Cardiotonic Agents; Drug Synergism; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; Tyrosine | 2012 |
Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats.
Topics: Age Factors; Aging; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Immunoprecipitation; Male; Maze Learning; Nerve Growth Factor; Nerve Growth Factors; Plasminogen; Protein Precursors; Rats; Rats, Inbred F344; Reaction Time; Tissue Plasminogen Activator; Tyrosine | 2012 |
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Gliosis; Glutathione; Humans; Lipid Peroxidation; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Neurons; Organophosphorus Compounds; Oxidative Stress; Peptide Fragments; Retention, Psychology; Rhodamines; Space Perception; Time Factors; Tyrosine; Ubiquinone | 2011 |
Aromatase immunoreactivity in fetal ovine neuronal cell cultures exposed to oxidative injury.
Topics: Animals; Aromatase; Brain; Female; Male; Neurons; Oxidative Stress; Primary Cell Culture; Sheep; Tyrosine | 2009 |
Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain.
Topics: Acute Disease; Aldehydes; Analgesics, Opioid; Animals; Antioxidants; Blood-Brain Barrier; Capillary Permeability; Carbon Radioisotopes; Codeine; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Hyperalgesia; Male; Membrane Proteins; Neuralgia; Neuritis; Occludin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Sucrose; Tight Junctions; Tyrosine; Xenobiotics | 2012 |
Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy.
Topics: Animals; Body Weight; Cation Transport Proteins; DNA; GPI-Linked Proteins; Hemochromatosis Protein; Hindlimb Suspension; Homeostasis; Iron; Lipid Peroxidation; Male; Membrane Proteins; Muscle, Skeletal; Muscular Atrophy; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred F344; Receptors, Transferrin; Recovery of Function; RNA; Tyrosine | 2012 |
Combined recombinant human activated protein C and ceftazidime prevent the onset of acute respiratory distress syndrome in severe sepsis.
Topics: Animals; Blood Gas Analysis; Ceftazidime; Female; Hemodynamics; Humans; Lung; Male; Myocardium; Oxygen; Peroxidase; Protein C; Recombinant Proteins; Respiratory Distress Syndrome; Sepsis; Sheep; Treatment Outcome; Tyrosine | 2012 |
Protective effect of apocynin, a NADPH-oxidase inhibitor, against contrast-induced nephropathy in the diabetic rats: a comparison with n-acetylcysteine.
Topics: Acetophenones; Acetylcysteine; Acute-Phase Proteins; Animals; Apoptosis; Contrast Media; Cytosine; Diabetic Nephropathies; Enzyme Activation; Enzyme Inhibitors; Glutathione Transferase; Iopamidol; Isoenzymes; Kidney Glomerulus; Lipocalin-2; Lipocalins; Male; NADPH Oxidases; Poly(ADP-ribose) Polymerases; Potassium; Proto-Oncogene Proteins; Rats; Rats, Wistar; Sodium; Time Factors; Tyrosine | 2012 |
Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy.
Topics: Adult; Aged; Antioxidants; Biomarkers; Blood Platelets; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fruit; Glutathione; Humans; Middle Aged; Oxidative Stress; Phenols; Photinia; Plant Extracts; Superoxides; Tyrosine | 2012 |
Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis.
Topics: Animals; Antioxidants; Ascorbic Acid; Capillary Permeability; Cecum; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Occludin; Peritonitis; Protein Phosphatase 2; Sepsis; Superoxides; Tyrosine | 2012 |
Cumulative 3-nitrotyrosine in specific muscle proteins is associated with muscle loss during aging.
Topics: Aging; Animals; Biomarkers; Body Weight; Energy Intake; Hindlimb; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Myofibrils; Organ Size; Protein Carbonylation; Quadriceps Muscle; Rats; Rats, Wistar; Sarcopenia; Tyrosine | 2012 |
Measurement of 3-nitro-tyrosine in human plasma and urine by gas chromatography-tandem mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Nitrites; Peroxynitrous Acid; Solubility; Tandem Mass Spectrometry; Tyrosine | 2012 |
Effects of glutamine supplementation on oxidative stress-related gene expression and antioxidant properties in rats with streptozotocin-induced type 2 diabetes.
Topics: Animals; Antioxidants; Base Sequence; Carrier Proteins; Cell Cycle Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Supplements; DNA Primers; Erythrocytes; Gene Expression; Glutamine; Glutathione; Kidney; Male; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2012 |
Emerging role of PPAR-β/δ in inflammatory process associated to experimental periodontitis.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Bone Resorption; Capillary Permeability; Cytokines; Dose-Response Relationship, Drug; Male; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Periodontitis; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Thiazoles; Tyrosine | 2011 |
Estradiol attenuates high glucose-induced endothelial nitrotyrosine: role for neuronal nitric oxide synthase.
Topics: Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Signal Transduction; Superoxides; Tyrosine | 2012 |
Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation.
Topics: Animals; Blood Pressure; Cardio-Renal Syndrome; Coronary Stenosis; Disease Models, Animal; Gene Expression; Heart Failure; Ligation; Male; Myocarditis; Nephrectomy; Nephritis; Nitrates; Nitrites; Peptidyl-Dipeptidase A; Prorenin Receptor; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Renal Insufficiency, Chronic; Renin; Thiobarbituric Acid Reactive Substances; Tyrosine; Ultrasonography | 2012 |
Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.
Topics: Acute-Phase Proteins; Aged; alpha-Synuclein; Biomarkers; Carrier Proteins; Endotoxins; Escherichia coli; Escherichia coli Infections; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Intestines; Male; Membrane Glycoproteins; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Permeability; Sucrose; Tyrosine | 2011 |
Investigation of local primary structure effects on peroxynitrite-mediated tyrosine nitration using targeted mass spectrometry.
Topics: Amino Acid Sequence; Molecular Sequence Data; Oligopeptides; Peroxynitrous Acid; Protein Processing, Post-Translational; Proteins; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2012 |
Lung heparan sulfates modulate K(fc) during increased vascular pressure: evidence for glycocalyx-mediated mechanotransduction.
Topics: Animals; Atrial Function, Left; Blood Pressure; Glucuronidase; Glycocalyx; Heparitin Sulfate; In Vitro Techniques; Lung; Male; Mechanotransduction, Cellular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Permeability; Porphyrins; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; S-Nitrosoglutathione; Tidal Volume; Tyrosine | 2012 |
Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation.
Topics: Animals; Cardiotonic Agents; Cell Shape; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Hypertrophy, Left Ventricular; L-Lactate Dehydrogenase; Male; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type II; Ouabain; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Superoxides; Time Factors; Tyrosine; Up-Regulation | 2012 |
β-Carotene and lycopene affect endothelial response to TNF-α reducing nitro-oxidative stress and interaction with monocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; beta Carotene; Biological Availability; Carotenoids; Cell Adhesion; Cell Adhesion Molecules; Cyclic GMP; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lycopene; Monocytes; NF-kappa B; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke.
Topics: Animals; Cerebral Arteries; Cerebrovascular Circulation; Crosses, Genetic; Ischemia; Leukocyte Common Antigens; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Models, Biological; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Reperfusion Injury; Stroke; Superoxides; Tyrosine | 2011 |
Lymphatic pump manipulation mobilizes inflammatory mediators into lymphatic circulation.
Topics: Animals; Chemokine CCL2; Chemokines; Cytokines; Dogs; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-4; Interleukin-6; Intestines; Lymph; Lymph Nodes; Lymphatic System; Lymphatic Vessels; Manipulation, Osteopathic; Superoxide Dismutase; Thoracic Duct; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice.
Topics: Animals; Apoptosis; Astrocytes; Basal Ganglia; Behavior, Animal; Cell Communication; Cells, Cultured; Chlorides; Coculture Techniques; Free Radical Scavengers; Male; Manganese Compounds; Manganese Poisoning; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase Type II; Tyrosine | 2012 |
Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antifungal Agents; Antimycin A; Calcium; Cardiolipins; Cimicifuga; Coloring Agents; Cyclic AMP Response Element-Binding Protein; Electron Transport Complex IV; Membrane Potential, Mitochondrial; Mice; Mitochondria; Oncogene Protein v-akt; Osteoblasts; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Saponins; Tetrazolium Salts; Thiazoles; Thioredoxin-Disulfide Reductase; Triterpenes; Tyrosine | 2013 |
Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Diabetes Mellitus, Experimental; Disease Models, Animal; Humans; Liver; Male; Microcirculation; Oxidative Stress; Phenols; Rats; Rats, Wistar; Tyrosine | 2013 |
Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia.
Topics: Amidines; Animals; Benzylamines; Brain; Endothelium; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Glycine; Homocysteine; Hyperhomocysteinemia; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Phenylacetates; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Stress, Physiological; Tyrosine | 2012 |
Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn.
Topics: Acetophenones; Animals; Animals, Newborn; Biopterins; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Hypertension, Pulmonary; Lung; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Pulmonary Artery; Reactive Oxygen Species; Sheep; Superoxides; Tyrosine; Vasoconstriction; Vasodilation | 2012 |
Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrin.
Topics: Aconitate Hydratase; Adenine Nucleotides; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Chromatography, High Pressure Liquid; Coenzyme A; Disease Models, Animal; Electroencephalography; Epilepsy; Fumarate Hydratase; Glutathione; Glutathione Disulfide; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidative Stress; Superoxide Dismutase; Tyrosine | 2012 |
RAGE mediates vascular injury and inflammation after global cerebral ischemia.
Topics: Animals; Brain Ischemia; Carotid Artery Injuries; Cell Death; Image Processing, Computer-Assisted; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuroglia; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Real-Time Polymerase Chain Reaction; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Stroke; Tumor Necrosis Factor-alpha; Tyrosine; Vascular System Injuries | 2012 |
Effects of ischemia and reperfusion on production of nitrotyrosine, activation of eosinophils, and apoptosis in the large colonic mucosa of horses.
Topics: Animals; Apoptosis; Colon; Colonic Diseases; Eosinophils; Female; Horse Diseases; Horses; In Situ Nick-End Labeling; Intestinal Mucosa; Ischemia; Male; Microscopy, Electron, Scanning; Oxidative Stress; Random Allocation; Reperfusion Injury; Tyrosine | 2012 |
S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine.
Topics: Adenosine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Cytochromes c; Endothelial Cells; Enzyme Inhibitors; Homocysteine; Humans; Hydrogen Peroxide; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Phosphatidylserines; S-Adenosylhomocysteine; Tyrosine | 2012 |
Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice.
Topics: Acute Disease; Alcohol Drinking; Alcoholism; Animals; Argininosuccinate Synthase; Chronic Disease; Cytochrome P-450 CYP2E1; Disease Models, Animal; Down-Regulation; Ethanol; Female; Hepatocytes; Immunohistochemistry; Lipid Peroxidation; Liver Diseases, Alcoholic; Male; Mice; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Tyrosine | 2012 |
Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions.
Topics: Apolipoprotein A-I; Atherosclerosis; Halogenation; Humans; Hypochlorous Acid; Lipoproteins, HDL; Nitrogen; Oxidation-Reduction; Oxidative Stress; Peroxidase; Protein Processing, Post-Translational; Tyrosine | 2012 |
New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.
Topics: Animals; Arginine; Biopterins; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Macrophages; Mice; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Respiratory Burst; Superoxides; Time Factors; Tyrosine | 2011 |
The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Chromatography, High Pressure Liquid; Colon; Deoxyguanosine; Dinoprost; Drinking Water; Female; gamma-Tocopherol; Immunoenzyme Techniques; Inflammation; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Tyrosine | 2012 |
Exhaled breath condensate (EBC) biomarkers in pulmonary fibrosis.
Topics: Biomarkers; Breath Tests; Carbon Monoxide; Exhalation; Female; Humans; Hydrogen Peroxide; Lung Diseases; Male; Nitric Oxide; Oxidative Stress; Pulmonary Fibrosis; Spirometry; Tyrosine | 2012 |
Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion.
Topics: Animals; Deoxyadenosines; Dependovirus; DNA Adducts; Female; Gene Transfer Techniques; Genetic Therapy; Ischemia; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Recombinant Proteins; Reperfusion Injury; Retina; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Superoxide Dismutase; Superoxides; Tyrosine | 2012 |
Nitric oxide synthase and tyrosine nitration in idiopathic asthenozoospermia: an immunohistochemical study.
Topics: Academic Medical Centers; Adult; Asthenozoospermia; Biomarkers; Case-Control Studies; Cell Shape; Citrulline; Humans; Immunohistochemistry; Italy; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Prospective Studies; Sperm Count; Sperm Motility; Spermatozoa; Tyrosine; Up-Regulation | 2012 |
Cytoprotective effect of nonsteroidal antiinflammatory drugs in rat brain slices subjected to reoxygenation after oxygen-glucose deprivation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytoprotection; Dinoprostone; Glucose; Hypoxia; Interleukin-10; Interleukin-1beta; L-Lactate Dehydrogenase; Lipid Peroxidation; Lipid Peroxides; Male; Neuroprotective Agents; Nitrites; Nitrosation; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Tyrosine | 2012 |
NGF and nitrosative stress in patients with Huntington's disease.
Topics: Adult; Biomarkers; Female; Humans; Huntington Disease; Male; Middle Aged; Nerve Growth Factor; Nitrosation; Severity of Illness Index; Tyrosine; Young Adult | 2012 |
The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye.
Topics: Animals; Caspase 3; Cytokines; Electroretinography; Endothelin-1; Glutathione; Hemodynamics; Intraocular Pressure; Intravitreal Injections; Laser-Doppler Flowmetry; Male; Nitrates; Nitric Oxide Donors; Ophthalmic Artery; Optic Disk; Rabbits; Reperfusion Injury; Retina; Retinal Diseases; Superoxide Dismutase; Tonometry, Ocular; Triamcinolone Acetonide; Tyrosine | 2012 |
Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Hyperglycemia; Hyperinsulinism; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Superoxides; Time Factors; Tyrosine | 2012 |
Rapid and sensitive determination of protein-nitrotyrosine by ELISA: Application to human plasma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Blood Proteins; Cattle; Detergents; Enzyme-Linked Immunosorbent Assay; Female; Humans; Limit of Detection; Middle Aged; Obesity; Oxidation-Reduction; Peroxynitrous Acid; Plasma; Polysorbates; Preservation, Biological; Protein Stability; Reference Standards; Sensitivity and Specificity; Serum; Serum Albumin, Bovine; Temperature; Time Factors; Tyrosine; Young Adult | 2012 |
Involvement of nitrosative stress in experimental periodontitis in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Activation; Male; Nitric Oxide Synthase Type II; Periodontitis; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Streptozocin; Stress, Physiological; Tyrosine | 2012 |
Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function.
Topics: Animals; Antimycin A; Antioxidants; Biphenyl Compounds; Cardiolipins; Cell Line; CREB-Binding Protein; Electron Transport; Lignans; Magnolia; Membrane Potential, Mitochondrial; Mice; Mitochondria; Osteoblasts; Osteoporosis; Oxidative Stress; Plant Extracts; Protective Agents; Reactive Oxygen Species; Tyrosine | 2012 |
Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts.
Topics: Acetylcysteine; Animals; Body Weight; Collagen; Female; Fetal Heart; Guinea Pigs; Hypoxia; Lipid Peroxidation; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Organ Size; Peroxynitrous Acid; Pregnancy; Tyrosine | 2012 |
Sesamin exerts renoprotective effects by enhancing NO bioactivity in renovascular hypertensive rats fed with high-fat-sucrose diet.
Topics: Animals; Antihypertensive Agents; Antioxidants; Diet, High-Fat; Dietary Sucrose; Dioxoles; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Hypertension, Renovascular; Hypolipidemic Agents; Kidney; Kidney Cortex; Lignans; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation | 2012 |
Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation.
Topics: Aldehydes; Animals; Body Composition; Free Radicals; Glucose Intolerance; Heart Failure; Hypertension; Insulin Resistance; Lipid Peroxidation; Liver; Male; Muscle, Skeletal; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiazolidinediones; Tyrosine | 2012 |
Exercise training blunts oxidative stress in sickle cell trait carriers.
Topics: Adult; Analysis of Variance; Biomarkers; Case-Control Studies; Catalase; E-Selectin; Endothelium, Vascular; Exercise; Exercise Test; France; Glutathione Peroxidase; Heterozygote; Humans; Male; Malondialdehyde; Nitrates; Nitrites; Oxidative Stress; P-Selectin; Protein Carbonylation; Sickle Cell Trait; Superoxide Dismutase; Time Factors; Tyrosine; Young Adult | 2012 |
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
Topics: Administration, Inhalation; Animals; Antioxidants; Apoptosis; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Injuries; Guanosine; Hydrogen; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Tyrosine; Water | 2012 |
The anti-inflammatory effects of methane.
Topics: Administration, Inhalation; Animals; Blood Gas Analysis; Dogs; Granulocytes; Inflammation; Intestinal Diseases; Intestinal Mucosa; Intestines; Male; Methane; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxides; Tyrosine | 2012 |
The chronic protective effects of limb remote preconditioning and the underlying mechanisms involved in inflammatory factors in rat stroke.
Topics: Animals; Extremities; Galectins; Inflammation; Ischemic Preconditioning; Nitric Oxide Synthase Type II; Rats; Receptors, Cell Surface; Stroke; Time Factors; Tyrosine | 2012 |
The use of melatonin in hypoxic-ischemic brain damage: an experimental study.
Topics: Animals; Animals, Newborn; Antioxidants; Biomarkers; Drug Evaluation, Preclinical; Female; Hypoxia-Ischemia, Brain; Melatonin; Microglia; Monocytes; Oxidative Stress; Pregnancy; Rats; Rats, Sprague-Dawley; Tyrosine | 2012 |
Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers.
Topics: Animals; Antioxidants; Calcium Signaling; Cell Membrane Permeability; Cytosol; Diaphragm; Electric Stimulation; Excitation Contraction Coupling; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Strength; Myofibrils; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Protein Carbonylation; Protein Processing, Post-Translational; Reactive Oxygen Species; Sphingomyelin Phosphodiesterase; Tyrosine | 2012 |
δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats.
Topics: Aldehydes; alpha-Tocopherol; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyclin D1; Dinoprost; Dinoprostone; gamma-Tocopherol; Immunohistochemistry; Male; Models, Chemical; Rats; Rats, Inbred F344; Tocopherols; Tyrosine | 2012 |
Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria.
Topics: Animals; Apoptosis; Aspartate Aminotransferases; Catalase; Cerium; Glutathione Reductase; Granuloma; Heme Oxygenase (Decyclizing); Hepatocytes; HSP70 Heat-Shock Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Kupffer Cells; Liver; Male; Microscopy, Electron, Transmission; Nanoparticles; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2012 |
Nitro-oxidative stress biomarkers in active and inactive men.
Topics: Adult; Age Factors; Biomarkers; Exercise; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Peroxidase; Sedentary Behavior; Tyrosine | 2012 |
A non-damaging method to analyze the configuration and dynamics of nitrotyrosines in proteins.
Topics: Cytochromes c; Nitrates; Nuclear Magnetic Resonance, Biomolecular; Peroxynitrous Acid; Proteins; Tyrosine | 2012 |
Biomarkers of oxidative stress in vascular dementia patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Biomarkers; Dementia, Vascular; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoprostanes; Male; Middle Aged; Oxidative Stress; Tyrosine | 2012 |
Evidence of oxidative injury of the spinal cord in 2 horses with equine degenerative myeloencephalopathy.
Topics: Aldehydes; Animals; Ataxia; Brain Diseases; Central Nervous System; Female; Horse Diseases; Horses; Immunohistochemistry; Neurodegenerative Diseases; Oxidative Stress; Spinal Cord Diseases; Tyrosine; Vitamin E; Vitamin E Deficiency | 2012 |
Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes.
Topics: Aged; Biomarkers; Blood Glucose; Coronary Angiography; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Inflammation Mediators; Interleukin-6; Logistic Models; Male; Middle Aged; Odds Ratio; Prediabetic State; Risk Assessment; Risk Factors; Taiwan; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Evidence for a role of frataxin in pancreatic islets isolated from multi-organ donors with and without type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Female; Frataxin; Gene Expression Regulation; Humans; Iron-Binding Proteins; Islets of Langerhans; Male; Middle Aged; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tissue Donors; Tyrosine | 2012 |
Catalytic peroxynitrite decomposition improves reperfusion injury after heart transplantation.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Coronary Circulation; Disease Models, Animal; Endothelium, Vascular; Energy Metabolism; Heart Transplantation; Immunohistochemistry; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Time Factors; Tyrosine; Vasodilation; Ventricular Function, Left; Ventricular Pressure | 2012 |
Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain.
Topics: Animals; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Blotting, Western; Dentate Gyrus; Ethidium; Fluorescent Dyes; Genotype; Hippocampus; Humans; Iron; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2012 |
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis.
Topics: Aldehydes; Animals; Apoptosis; Blood Glucose; Blotting, Western; Cataract; Cattle; Diabetes Complications; Extracellular Signal-Regulated MAP Kinases; Fasting; Guanidines; In Situ Nick-End Labeling; Lens, Crystalline; Male; Nitrosation; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Retina; Sodium-Hydrogen Exchangers; Sulfones; Tyrosine | 2012 |
Effect of α-thalassaemia on exercise-induced oxidative stress in sickle cell trait.
Topics: Adult; alpha-Thalassemia; Antioxidants; Biomarkers; Exercise; Fluorescence Recovery After Photobleaching; Humans; Male; Nitric Oxide; Oxidative Stress; Sickle Cell Trait; Tyrosine; Young Adult | 2012 |
Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes.
Topics: Animals; Benzoquinones; Calcium; Diabetic Nephropathies; Diet, High-Fat; Disease Models, Animal; HSP90 Heat-Shock Proteins; Kaplan-Meier Estimate; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Lactams, Macrocyclic; Male; Mice; Mice, Knockout; Mitochondria; Renal Insufficiency; Tyrosine | 2012 |
The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans.
Topics: Colitis; Colonic Neoplasms; HT29 Cells; Humans; Immunohistochemistry; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; Tumor Cells, Cultured; Tyrosine | 2012 |
Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.
Topics: Age Factors; Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Dose-Response Relationship, Drug; Environmental Pollutants; Gene Expression Regulation; Glutathione; Hippocampus; Homeostasis; Male; Methylation; Mice; Nerve Growth Factor; Nerve Growth Factors; Neurotoxicity Syndromes; Oxidation-Reduction; Oxidative Stress; Trichloroethylene; Tyrosine | 2012 |
Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.
Topics: Amino Acids; Animals; Crystallography, X-Ray; H-2 Antigens; Inflammation; Lymphocytic choriomeningitis virus; Major Histocompatibility Complex; Mice; Models, Molecular; Peptides; Protein Conformation; Protein Stability; Receptors, Antigen, T-Cell; Tyrosine; Viral Proteins | 2012 |
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1β-induced accumulation of β-amyloid and cell death.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Death; Cells, Cultured; Dactinomycin; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-1beta; Muscle Cells; Myositis, Inclusion Body; Nitric Oxide Synthase Type II; RNA, Messenger; Tyrosine | 2012 |
Cerebral white matter oxidation and nitrosylation in young rodents with kaolin-induced hydrocephalus.
Topics: Age Factors; Animals; Female; Hydrocephalus; Kaolin; Leukoencephalopathies; Male; Mice; Mice, Knockout; Nerve Fibers, Myelinated; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Tyrosine | 2012 |
Reduction of uric acid levels with allopurinol treatment improves endothelial function in patients with chronic kidney disease.
Topics: Adolescent; Adult; Albumins; Algorithms; Allopurinol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Body Mass Index; C-Reactive Protein; Creatinine; Endothelium, Vascular; Female; Humans; Hyperuricemia; Lipoproteins, LDL; Male; Middle Aged; Prospective Studies; Reactive Oxygen Species; Renal Insufficiency, Chronic; Treatment Outcome; Tyrosine; Uricosuric Agents | 2012 |
A simple and robust LC-MS/MS method for quantification of free 3-nitrotyrosine in human plasma from patients receiving on-pump CABG surgery.
Topics: Acetic Acid; Chromatography, Liquid; Coronary Artery Bypass; Drug Stability; Humans; Limit of Detection; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tyrosine | 2012 |
Platelet-rich plasma stimulates cytokine expression and alkaline phosphatase activity in osteoblast-derived osteosarcoma cells.
Topics: Alkaline Phosphatase; Cell Line, Tumor; Chemokine CCL5; Chemokine CXCL1; Complement C5; Cytokines; Dose-Response Relationship, Drug; Escherichia coli; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intercellular Adhesion Molecule-1; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Interleukins; Lipopolysaccharides; Nitric Oxide; Osteoblasts; Oxidative Stress; Platelet-Rich Plasma; RANK Ligand; Tyrosine | 2012 |
Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria; Nitric Oxide Synthase Type II; Oxidative Stress; Polysaccharides; Reishi; Shc Signaling Adaptor Proteins; Skin; Src Homology 2 Domain-Containing, Transforming Protein 1; Streptozocin; Superoxide Dismutase; Tyrosine; Wound Healing | 2012 |
Enhanced sample multiplexing for nitrotyrosine-modified proteins using combined precursor isotopic labeling and isobaric tagging.
Topics: Amino Acid Sequence; Animals; Cattle; Dithionite; Isotope Labeling; Lysine; Mice; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational; Serum Albumin, Bovine; Spleen; Tandem Mass Spectrometry; Tyrosine | 2012 |
The effect of hemolysis on plasma oxidation and nitration in patients with sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Bilirubin; Biomarkers; Child; Child, Preschool; Dinoprost; Erythrocyte Indices; Female; Haptoglobins; Hemoglobin A; Hemoglobin, Sickle; Hemolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Male; Nitric Oxide; Oxidation-Reduction; Reticulocyte Count; Reticulocytes; Tyrosine | 2012 |
High-throughput, multiplexed analysis of 3-nitrotyrosine in individual proteins.
Topics: Enzyme-Linked Immunosorbent Assay; Humans; Proteins; Tyrosine | 2012 |
Nitric oxide is responsible for oxidative skin injury and modulation of cell proliferation after 24 hours of UVB exposures.
Topics: Animals; Biomarkers; Cell Proliferation; Enzyme Inhibitors; Gene Expression; Guanidines; Lipid Peroxidation; Male; Mice; Mice, Hairless; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Proliferating Cell Nuclear Antigen; Radiation Injuries, Experimental; Skin; Tyrosine; Ultraviolet Rays; Vascular Endothelial Growth Factor A | 2012 |
Deficiency of inducible nitric oxide synthase attenuates immobilization-induced skeletal muscle atrophy in mice.
Topics: Aconitate Hydratase; Animals; Enzyme Inhibitors; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucose; Hindlimb Suspension; Lysine; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Nitric Oxide Synthase Type II; Phosphorylation; Protein Carbonylation; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; SKP Cullin F-Box Protein Ligases; Superoxide Dismutase; TOR Serine-Threonine Kinases; Tripartite Motif Proteins; Tyrosine; Ubiquitin-Protein Ligases | 2012 |
Proteins from Avastin® (bevacizumab) show tyrosine nitrations for which the consequences are completely unclear.
Topics: Antibodies, Monoclonal, Humanized; Bevacizumab; Electrophoresis, Gel, Two-Dimensional; Protein Processing, Post-Translational; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tyrosine | 2012 |
A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging.
Topics: Aging; Animals; Brain; Cognition; Dietary Supplements; Growth Hormone; Mice; Mice, Transgenic; Mitochondria; Stress, Physiological; Tyrosine | 2012 |
Biomarkers of subclinical atherosclerosis in patients with autoimmune disorders.
Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Atherosclerosis; beta Carotene; Carotid Artery, Common; Carotid Intima-Media Thickness; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide; Risk; Tyrosine; Vitamin A; Vitamin E | 2012 |
A phytochemical approach to experimental metabolic syndrome-associated renal damage and oxidative stress.
Topics: 2,4-Dinitrophenol; Animals; Antioxidants; Fructose; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Metabolic Syndrome; Oxidation-Reduction; Oxidative Stress; Phytotherapy; Rats; Rats, Wistar; Tyrosine | 2012 |
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Binding Proteins; Cerebral Cortex; Deoxyguanosine; Dinoprostone; Disease Models, Animal; Encephalitis; Free Radical Scavengers; Free Radicals; Gene Expression Regulation; Humans; Ibuprofen; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Motor Neurons; Oxidative Stress; Riluzole; Spinal Cord; Sulfasalazine; Superoxide Dismutase; Tyrosine | 2012 |
Evidence of increased oxidative stress in aged mesenteric lymphatic vessels.
Topics: Age Factors; Aging; Animals; Blotting, Western; Immunohistochemistry; Lipid Peroxidation; Lymphatic Vessels; Male; Mesentery; Mitochondria; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Thiobarbituric Acid Reactive Substances; Tyrosine | 2012 |
Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats.
Topics: Aldehydes; Animals; bcl-2-Associated X Protein; Caspase 8; Ethanol; Female; Hemorrhage; Liver; Nitric Oxide Synthase Type II; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Resuscitation; Tyrosine | 2012 |
Cardoguard, an Ayurvedic antihypertensive formulation, prevents cardiac remodeling in spontaneously hypertensive rats by inhibition of ERK and PKCε signaling pathways.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Cardiotonic Agents; Endomyocardial Fibrosis; Extracellular Signal-Regulated MAP Kinases; Heart; Hypertrophy, Left Ventricular; Male; MAP Kinase Signaling System; Medicine, Ayurvedic; Myocytes, Cardiac; Oxidative Stress; Protein Kinase C-epsilon; Rats; Rats, Inbred SHR; Rats, Wistar; Signal Transduction; Tyrosine; Ventricular Remodeling | 2012 |
Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Animals; Bromodeoxyuridine; Cell Proliferation; Cell Survival; Dentate Gyrus; Deoxyguanosine; Disease Models, Animal; Exercise Test; Female; Gene Expression Regulation; Hippocampus; Intercellular Signaling Peptides and Proteins; Male; Mice; Neurogenesis; Neurons; Oxidative Stress; Phenotype; Physical Conditioning, Animal; RNA, Messenger; Sex Characteristics; Tyrosine | 2012 |
Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood-Brain Barrier; Calcium-Binding Proteins; Cell Death; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Gaucher Disease; Gene Expression Regulation, Developmental; Glucosylceramidase; Ibuprofen; Immunoglobulin G; Intercellular Adhesion Molecule-1; Intermediate Filament Proteins; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Nerve Tissue Proteins; Nestin; Neurons; TATA Box; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2012 |
[Effect of jinmaitong capsule on inducible nitric oxide synthase and nitrotyrosine in diabetic rats].
Topics: Animals; Blood Glucose; Body Weight; Capsules; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drugs, Chinese Herbal; Enzyme Activation; Male; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Tyrosine | 2012 |
Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone.
Topics: Actins; Animals; Cell Hypoxia; Cerebrovascular Circulation; Diabetes Mellitus, Type 2; Disease Models, Animal; Hyperemia; Male; Metalloporphyrins; Middle Cerebral Artery; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2012 |
Postprandial impairment of flow-mediated dilation and elevated methylglyoxal after simple but not complex carbohydrate consumption in dogs.
Topics: Animals; Blood Glucose; Cross-Over Studies; Dietary Carbohydrates; Dogs; Female; Glycemic Index; Hemodynamics; Hyperglycemia; Insulin; Male; Oxidative Stress; Postprandial Period; Pyruvaldehyde; Tyrosine | 2012 |
Does oxidative stress play a critical role in cardiovascular complications of Kawasaki disease?
Topics: Case-Control Studies; Child, Preschool; Erythrocytes; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2012 |
Protective effects of grape seed extract against oxidative and nitrative damage of plasma proteins.
Topics: Antioxidants; Blood Proteins; Grape Seed Extract; Humans; Oxidation-Reduction; Oxidative Stress; Tyrosine | 2012 |
Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.
Topics: Aging; Animals; Antioxidants; Aorta; Collagen Type I; Drug Evaluation, Preclinical; Elasticity; Elastin; Glycation End Products, Advanced; Male; Mice; Oxidative Stress; Pyrogallol; Sodium Nitrite; Superoxides; Tissue Culture Techniques; Transforming Growth Factor beta; Tyrosine; Vascular Stiffness | 2012 |
Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydrogen; Lipoproteins, LDL; Lysine; Male; Oxidative Stress; Periodontitis; Rats; Rats, Wistar; Reactive Oxygen Species; Statistics, Nonparametric; Tyrosine; Water | 2012 |
Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers.
Topics: Adenosine; Alanine Transaminase; Allopurinol; Amidines; Animals; Benzylamines; Bilirubin; Caspase 3; Ethanol; Fatty Liver; Female; Gene Expression; Glutathione; Graft Survival; Insulin; JNK Mitogen-Activated Protein Kinases; Liver Transplantation; Membrane Potential, Mitochondrial; Mitochondria; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Organ Preservation Solutions; Raffinose; Rats; Rats, Inbred Lew; Reactive Nitrogen Species; Tyrosine | 2012 |
Oxidative damage to pre-eclamptic placenta: immunohistochemical expression of VEGF, nitrotyrosine residues and von Willebrand factor.
Topics: Adult; Case-Control Studies; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Oxidative Stress; Peroxynitrous Acid; Placenta; Pre-Eclampsia; Pregnancy; Tissue Distribution; Trophoblasts; Tyrosine; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2012 |
Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model.
Topics: Activating Transcription Factor 3; Animals; Apoptosis; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase; Glutathione Disulfide; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Lung; Mice; Oxidation-Reduction; Oxidative Stress; Pulmonary Fibrosis; Respiratory Mucosa; Transcription, Genetic; Transforming Growth Factor beta1; Tyrosine | 2012 |
Nitrosative stress induces proliferation and viability changes in high glucose-exposed rat Schwannoma cells.
Topics: Animals; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diabetic Neuropathies; Glucose; Hyperglycemia; Neurilemmoma; Oxidative Stress; Rats; Reactive Nitrogen Species; Schwann Cells; Tyrosine | 2012 |
[Effect of nitric oxide on 1 ml: peritoneal macrophages activity in normal pregnancy in white rats].
Topics: Animals; Female; Free Radicals; Lipid Peroxidation; Macrophages, Peritoneal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phagocytosis; Pregnancy; Rats; Sodium Nitrite; Tyrosine | 2012 |
Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Disease Models, Animal; Female; Lung; Microcirculation; Nitric Oxide; Pneumonia; Pseudomonas aeruginosa; Pseudomonas Infections; Pulmonary Circulation; Pulmonary Edema; Pulmonary Gas Exchange; RNA, Messenger; Sepsis; Sheep; Smoke Inhalation Injury; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A | 2012 |
Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet.
Topics: Action Potentials; Animal Feed; Animals; Antioxidants; Biological Transport; Catalase; Diet, High-Fat; Glucose; Glutathione Disulfide; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Muscle, Skeletal; Nitric Oxide; Physical Conditioning, Animal; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2012 |
Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization.
Topics: Age Factors; Aging; Animals; Blood Flow Velocity; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; NADPH Oxidase 2; NADPH Oxidases; Neovascularization, Physiologic; Oxidative Stress; Recovery of Function; Regional Blood Flow; Stem Cells; Superoxides; Time Factors; Tyrosine; Vascular Diseases | 2012 |
Morphological, immunohistochemical and biochemical effects of non-pulsatile ex vivo perfusion with crescent pressures in human saphenous veins.
Topics: Aged; Female; Humans; Immunohistochemistry; In Vitro Techniques; Male; Malondialdehyde; Microscopy, Electron, Transmission; Middle Aged; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Perfusion; Pressure; Saphenous Vein; Stress, Mechanical; Tyrosine | 2015 |
Nitrotyrosine and nitrate/nitrite levels in cardiac arrest survivors treated with endovascular hypothermia.
Topics: Female; Heart Arrest; Humans; Hypothermia; Hypothermia, Induced; Male; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Tyrosine | 2012 |
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta; Blotting, Western; Chemokine CCL2; Ethidium; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Mice, Knockout; NADPH Oxidases; Peptidyl-Dipeptidase A; Peroxynitrous Acid; Profilins; Real-Time Polymerase Chain Reaction; Tyrosine | 2012 |
Altered neuronal nitric oxide synthase in the aging vascular system: implications for estrogens therapy.
Topics: Aging; Animals; Aorta, Thoracic; Arginine; Blotting, Western; Estradiol; Female; In Vitro Techniques; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Ovariectomy; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2012 |
Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.
Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Asphyxia; Bronchoalveolar Lavage; DNA Primers; Enzyme-Linked Immunosorbent Assay; Hyaluronic Acid; Interleukin-1beta; Lung; Oxidative Stress; Oxygen Inhalation Therapy; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; Sus scrofa; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Blockade of TGF-β 1 signalling inhibits cardiac NADPH oxidase overactivity in hypertensive rats.
Topics: Animals; Blood Pressure; Cell Line; Collagen Type I; Fibroblasts; Heart; Hypertension; Male; Membrane Glycoproteins; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Peptide Fragments; Rats; Rats, Inbred WKY; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta1; Tyrosine | 2012 |
Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
Topics: Analysis of Variance; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Gait Disorders, Neurologic; Gene Expression Regulation; Globins; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neuroglobin; Neuroprotective Agents; Seizures; Space Perception; Tyrosine | 2012 |
Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications.
Topics: Cell Membrane; Deferoxamine; Erythrocytes; Free Radical Scavengers; Humans; Lung; Nitrogen Dioxide; Oxidants, Photochemical; Peroxidase; Proteins; Siderophores; Tyrosine | 2012 |
Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes.
Topics: Adult; Aged; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Linear Models; Lipid Peroxides; Male; Microcirculation; Middle Aged; Multivariate Analysis; Oxidative Stress; Prevalence; Severity of Illness Index; Skin; Sleep Apnea, Obstructive; Tyrosine | 2012 |
Application of immunohistochemical staining to detect antigen destruction as a measure of tissue damage.
Topics: Animals; Antibodies; Antibody Specificity; Antigens; Coloring Agents; Cross Reactions; Eosine Yellowish-(YS); Fixatives; Formaldehyde; Hematoxylin; Hot Temperature; Immunohistochemistry; Paraffin Embedding; Protein Denaturation; Protein Folding; Receptor, ErbB-2; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Tyrosine | 2012 |
Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gene Expression; Hypertension; Inflammation; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; MAP Kinase Kinase 4; NF-kappa B; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Retina; Retinal Neovascularization; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Mass spectrometrical analysis of bilin-binding protein from the wing of Hebomoia glaucippe (Linnaeus, 1758) (Lepidoptera: Pieridae).
Topics: Amino Acid Sequence; Animals; Apolipoproteins D; Blotting, Western; Brain Chemistry; Butterflies; Carrier Proteins; Electrophoresis, Gel, Two-Dimensional; Insect Proteins; Lysine; Mice; Molecular Sequence Data; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine; Wings, Animal | 2012 |
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclooxygenase 2; Disease Models, Animal; Galactosamine; Gene Expression Regulation; Heme Oxygenase-1; Hepatitis; Interleukin-6; Lactones; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 8; NF-kappa B; Phosphorylation; Sesquiterpenes; STAT3 Transcription Factor; Transaminases; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2013 |
Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure.
Topics: Aldehydes; Animals; Antioxidants; Brain; Cerium; Dose-Response Relationship, Drug; Glutathione Peroxidase; Glutathione Reductase; HSP70 Heat-Shock Proteins; Male; Mass Spectrometry; Microscopy, Electron; Nanostructures; Nitric Oxide Synthase Type II; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Spectroscopy, Electron Energy-Loss; Superoxide Dismutase; Tyrosine | 2012 |
Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Folic Acid; Hyperalgesia; Male; Nerve Fibers; Neural Conduction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pyridoxal Phosphate; Rats; Rats, Zucker; Sciatic Nerve; Tibial Nerve; Tyrosine; Vitamin B 12 | 2012 |
Fluorescence lifetime measurements of intrinsically unstructured proteins: application to α-synuclein.
Topics: Algorithms; alpha-Synuclein; Amino Acid Substitution; Anisotropy; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Naphthalenesulfonates; Protein Conformation; Spectrometry, Fluorescence; Staining and Labeling; Tryptophan; Tyrosine | 2012 |
Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Catalase; Cerebral Cortex; Disease Models, Animal; Female; Glutathione; Hemodynamics; Hydrogen Peroxide; Hypoxia; Infusions, Intravenous; Lactic Acid; Male; Oxidation-Reduction; Oxidative Stress; Oxygen; Pulmonary Alveoli; Resuscitation; Sodium Bicarbonate; Superoxide Dismutase; Swine; Tyrosine | 2012 |
Trehalose treatment accelerates the healing of UVB-irradiated corneas. Comparative immunohistochemical studies on corneal cryostat sections and corneal impression cytology.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Corneal Diseases; Cytodiagnosis; Epithelium, Corneal; Female; Frozen Sections; Immunohistochemistry; Injections, Intraocular; Malondialdehyde; Neovascularization, Pathologic; Oxidative Stress; Rabbits; Radiation Injuries, Experimental; Trehalose; Tyrosine; Ultraviolet Rays; Urokinase-Type Plasminogen Activator; Wound Healing | 2012 |
Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase.
Topics: Biological Availability; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; RNA, Messenger; RNA, Small Interfering; Tobacco Smoke Pollution; Tyrosine | 2012 |
Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury.
Topics: Acute Lung Injury; Adult; Aged; Animals; Biomarkers; Capillary Permeability; Case-Control Studies; Cell-Derived Microparticles; Cells, Cultured; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Female; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Lipopolysaccharides; Lung; Male; Mice; Middle Aged; Pulmonary Artery; Receptors, Lysosphingolipid; RNA Interference; Sphingosine-1-Phosphate Receptors; Tyrosine; Ventilator-Induced Lung Injury | 2012 |
Palmitoylethanolamide reduces early renal dysfunction and injury caused by experimental ischemia and reperfusion in mice.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Cell Adhesion Molecules; Endocannabinoids; Ethanolamines; gamma-Glutamyltransferase; Gene Expression Regulation; Kidney; Leukocytes; Mice; Mice, Knockout; Palmitic Acids; Poly Adenosine Diphosphate Ribose; PPAR alpha; Reperfusion Injury; Tyrosine | 2012 |
Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus.
Topics: Animals; Blood Glucose; Cells, Cultured; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Activation; Free Radical Scavengers; Gene Expression Regulation; Green Fluorescent Proteins; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Oxidative Stress; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA Interference; Time Factors; Tyrosine; Ubiquitination | 2012 |
Determination of nitrotyrosine in Arabidopsis thaliana cell cultures with a mixed-mode solid-phase extraction cleanup followed by liquid chromatography time-of-flight mass spectrometry.
Topics: Arabidopsis; Chromatography, Liquid; Limit of Detection; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2012 |
Bladder pain syndrome/interstitial cystitis ESSIC type 3C: high expression of inducible nitric oxide synthase in inflammatory cells.
Topics: Biomarkers; Biopsy; Cystitis, Interstitial; Humans; Inflammation; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Retrospective Studies; Syndrome; Tyrosine; Urinary Bladder; Urinary Bladder Diseases; Urothelium | 2013 |
Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction.
Topics: Acetylglucosamine; Acylation; Animals; Aorta, Thoracic; Aortic Diseases; beta-N-Acetylhexosaminidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Inflammation; Inflammation Mediators; Male; Myography; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Culture Techniques; Tumor Necrosis Factor-alpha; Tyrosine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2012 |
N-methyl-D-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Hemodynamics; Interleukin-6; Kynurenic Acid; Male; Microcirculation; Nitric Oxide; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Xanthine Dehydrogenase | 2012 |
Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.
Topics: Aortic Valve Stenosis; Biopsy; Cohort Studies; Comorbidity; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus; Female; Heart; Heart Failure; Humans; Male; Middle Aged; Myocardium; Natriuretic Peptide, Brain; Obesity; Oxidative Stress; Stroke Volume; Tyrosine | 2012 |
Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Forkhead Box Protein O1; Forkhead Transcription Factors; Genistein; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Sirtuin 1; Streptozocin; Superoxides; Tyrosine; Wound Healing | 2013 |
Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Agonists; Animals; Aorta; Cholinergic Agonists; Cyclic GMP; Glutamate-Cysteine Ligase; Glutathione; In Vitro Techniques; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oligonucleotide Array Sequence Analysis; Phenylephrine; Reactive Oxygen Species; Transcriptome; Tyrosine; Vasoconstriction; Vasodilation | 2012 |
The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.
Topics: Acetophenones; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Free Radical Scavengers; Imines; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide Synthase Type II; Organometallic Compounds; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Small Interfering; Salicylates; Superoxides; Thioredoxins; Tyrosine | 2012 |
The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus.
Topics: Barrett Esophagus; Carcinoma, Squamous Cell; CDX2 Transcription Factor; Cell Line, Tumor; Epithelium; ErbB Receptors; Esophagogastric Junction; Homeodomain Proteins; Humans; Immunohistochemistry; Metaplasia; Nitric Oxide; Phosphorylation; Tyrosine | 2012 |
Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy.
Topics: Aldehyde Reductase; Animals; Animals, Newborn; Blotting, Western; Calcium-Binding Proteins; Capillary Permeability; Cell Movement; Cell Proliferation; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; I-kappa B Proteins; Immunohistochemistry; Infant, Newborn; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Nerve Tissue Proteins; Oxidative Stress; Oxygen; Poly Adenosine Diphosphate Ribose; Proto-Oncogene Proteins c-akt; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Tyrosine; Vascular Endothelial Growth Factor A | 2012 |
Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Echocardiography; Heart; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Inflammation; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Lythraceae; Male; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
Selective cerebral perfusion using moderate flow in complex cardiac surgery provides sufficient neuroprotection. Are children young adults?
Topics: Animals; Apoptosis Inducing Factor; Biomarkers; Brain; Cardiopulmonary Bypass; Carotid Artery, Common; Hippocampus; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Intracranial Pressure; Intraoperative Complications; Monitoring, Intraoperative; Perfusion; Random Allocation; Swine; Treatment Outcome; Tyrosine | 2012 |
Enrichment and detection of tyrosine-nitrated proteins.
Topics: Animals; Biotin; Blotting, Western; Fluorescent Dyes; Humans; Immunochemistry; Mass Spectrometry; Microscopy, Fluorescence; Models, Molecular; Oxidation-Reduction; Proteins; Staining and Labeling; Tyrosine | 2012 |
Increased cellular and circulating biomarkers of oxidative stress in nascent metabolic syndrome.
Topics: Adult; Biomarkers; Body Mass Index; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Lipoproteins, LDL; Male; Metabolic Syndrome; Middle Aged; Monocytes; NADPH Oxidases; NF-E2 Transcription Factor; Oxidative Stress; Prevalence; Risk Factors; Superoxides; Tyrosine | 2012 |
Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Anthocyanins; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Glutathione Transferase; Immunoenzyme Techniques; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oxidative Stress; Phytotherapy; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Ribes; RNA, Messenger; Signal Transduction; Tyrosine | 2012 |
Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.
Topics: Analysis of Variance; Animals; Carrageenan; CD11b Antigen; Cell Line, Transformed; Chromatography, Liquid; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electrochemical Techniques; Enkephalin, Methionine; Glial Fibrillary Acidic Protein; Humans; Hyperalgesia; Injections, Spinal; Male; Medulla Oblongata; Metalloporphyrins; Microinjections; Neuroglia; Neurons; Opioid Peptides; Pain; Pain Measurement; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2012 |
The dose-dependent immunoregulatory effects of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester in rats with sub-acute peritonitis.
Topics: Acute Disease; Animals; Arginine; Body Weight; Cell Proliferation; Cytokines; Dose-Response Relationship, Drug; Humans; Immunomodulation; Infusions, Parenteral; Leukocyte Count; Leukocytes; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Organ Size; Parenteral Nutrition; Peritonitis; Rats; Rats, Wistar; Spleen; Tyrosine | 2012 |
Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis.
Topics: Animals; Autophagy; Cell Line; Cells, Cultured; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Hyperammonemia; Liver Cirrhosis; Male; Mice; Microscopy, Confocal; Microscopy, Electron; Microtubule-Associated Proteins; Muscle Proteins; Muscle, Skeletal; Portacaval Shunt, Surgical; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA; Sarcopenia; Transfection; Tyrosine | 2012 |
When is mass spectrometry combined with affinity approaches essential? A case study of tyrosine nitration in proteins.
Topics: Amino Acid Sequence; Animals; Antibodies, Immobilized; Binding Sites; Chromatography, Affinity; Cystic Fibrosis; Eosinophil Granule Proteins; Humans; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Tyrosine | 2012 |
Developments in the synthesis of a water compatible molecularly imprinted polymer as artificial receptor for detection of 3-nitro-L-tyrosine in neurological diseases.
Topics: Biocompatible Materials; Biomarkers; Biomimetic Materials; Biosensing Techniques; Equipment Design; Equipment Failure Analysis; Humans; Molecular Imprinting; Neurodegenerative Diseases; Polymers; Reproducibility of Results; Sensitivity and Specificity; Tyrosine; Water | 2013 |
Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes.
Topics: Acetylcholine; Animals; Aorta; Atherosclerosis; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Cholesterol, Dietary; Creatinine; Diabetes Complications; Diabetes Mellitus, Type 2; Diet, High-Fat; Dose-Response Relationship, Drug; Endothelin-1; Hyperglycemia; Hypertrophy; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; Lipids; Male; Malondialdehyde; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide; Phytotherapy; Plant Extracts; Prunella; Transforming Growth Factor beta1; Tunica Intima; Tunica Media; Tyrosine; Vascular Cell Adhesion Molecule-1; Vasodilation | 2012 |
Bradykinin- and lipopolysaccharide-induced bradykinin B2 receptor expression, interleukin 8 release and "nitrosative stress" in bronchial epithelial cells BEAS-2B: role for neutrophils.
Topics: Bradykinin; Bronchi; Cell Line; Coculture Techniques; Epithelial Cells; Gene Expression Regulation; Humans; Interleukin-8; Lipopolysaccharides; Neutrophils; Peroxidase; Reactive Nitrogen Species; Receptor, Bradykinin B2; Tyrosine | 2012 |
Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Chemokine CXCL10; Culture Media, Serum-Free; Cytokines; Endothelial Cells; Endothelium, Vascular; Female; Humans; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Microvessels; Neoplasm Proteins; Nicotiana; Plant Extracts; Receptors, CXCR3; RNA-Binding Proteins; Smoke; Tyrosine; Up-Regulation | 2012 |
[Characterization of the antiinflammatory properties of methane inhalation during ischaemia-reperfusion].
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Dioxide; Disease Models, Animal; Dogs; Hemodynamics; Inflammation; Intestine, Small; Leukocytes; Methane; Peroxidase; Random Allocation; Reperfusion Injury; Superoxides; Tyrosine | 2012 |
Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blood Glucose; Cell Nucleus; Cells, Cultured; Diabetes Mellitus, Experimental; Diazoxide; Forkhead Transcription Factors; Glucose; Hyperglycemia; Male; Myocardium; Myocytes, Cardiac; Nerve Tissue Proteins; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Nitrogen Species; Stress, Physiological; Tyrosine | 2012 |
Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin.
Topics: Analysis of Variance; Antioxidants; Cell Line; Endothelial Cells; Glucose; Histocytochemistry; Humans; Intracellular Signaling Peptides and Proteins; Ischemia; Kelch-Like ECH-Associated Protein 1; Melatonin; Microscopy, Fluorescence; NF-E2-Related Factor 2; Nitrates; Oxygen; Stress, Physiological; Tyrosine | 2013 |
Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers.
Topics: Animals; Biomarkers; Humans; Hypertension, Pulmonary; Lung; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Smoking; Tyrosine | 2012 |
Reactive nitrogen oxide species-induced post-translational modifications in human hemoglobin and the association with cigarette smoking.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Hemoglobins; Humans; Methionine; Molecular Sequence Data; Oxidation-Reduction; Peptides; Peroxynitrous Acid; Protein Processing, Post-Translational; Reactive Nitrogen Species; Smoking; Spectrometry, Mass, Electrospray Ionization; Sulfinic Acids; Tyrosine | 2012 |
Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Disease Models, Animal; Functional Laterality; Gene Expression Regulation; Mice; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Protein Isoforms; RNA, Messenger; Time Factors; Tyrosine | 2012 |
Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.
Topics: Angiopoietin-2; Animals; Arginine Vasopressin; Arterial Pressure; Blood Vessels; Capillary Permeability; Disease Models, Animal; Female; Hemodynamics; Infusions, Intravenous; Methicillin-Resistant Staphylococcus aureus; Neutrophil Infiltration; Nitric Oxide; Pneumonia, Staphylococcal; Receptors, Vasopressin; Sepsis; Sheep; Smoke Inhalation Injury; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vasoconstriction; Vasoconstrictor Agents; Vasotocin; Ventricular Function, Left | 2012 |
Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aged; Arterioles; Cardiopulmonary Bypass; Coronary Artery Bypass; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Disease Susceptibility; Endothelium, Vascular; Enzyme Induction; Female; Gene Expression Regulation; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Male; Microcirculation; Middle Aged; Muscle, Skeletal; Nitroprusside; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Substance P; Tyrosine; Vasoconstriction; Vasodilator Agents | 2012 |
Oxidative stress in patients with essential hypertension: a comparison of dippers and non-dippers.
Topics: Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Prospective Studies; Tyrosine | 2013 |
Hyperoxemic reperfusion after prolonged cardiac arrest in a rat cardiopulmonary bypass resuscitation model.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Cardiopulmonary Bypass; Heart Arrest; Hemodynamics; Hyperoxia; Immunohistochemistry; Male; Mitochondria, Heart; Oxygen Inhalation Therapy; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2013 |
Modulation of methamphetamine-induced nitric oxide production by neuropeptide Y in the murine striatum.
Topics: Analysis of Variance; Animals; Arginine; Caspase 3; Corpus Striatum; Cyclic GMP; Drug Interactions; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Neuropeptide Y; Nitric Oxide Synthase Type II; Peptides; Protein Precursors; Receptors, Neuropeptide Y; RNA, Messenger; Tyrosine | 2012 |
Preconditioning protects the heart in a prolonged uremic condition.
Topics: Angiotensin II; Animals; Biomarkers; Creatinine; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nephrectomy; Proteinuria; Rats; Rats, Wistar; Stroke Volume; Time Factors; Tyrosine; Ultrasonography; Urea; Uremia; Uric Acid; Ventricular Function, Left | 2012 |
Role of peroxynitrite-modified H2A histone in the induction and progression of rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Disease Progression; Histones; Humans; Immunoglobulin G; Peroxynitrous Acid; Rheumatoid Factor; Tyrosine | 2012 |
Fluorogenic tagging of protein 3-nitrotyrosine with 4-(aminomethyl)benzene sulfonate in tissues: a useful alternative to Immunohistochemistry for fluorescence microscopy imaging of protein nitration.
Topics: Animals; Benzene Derivatives; Biomarkers; Cerebellum; Immunohistochemistry; Methylamines; Microscopy, Fluorescence; Nitro Compounds; Proteins; Purkinje Cells; Rats; Rats, Sprague-Dawley; Tyrosine | 2012 |
Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.
Topics: Animals; Glutathione Peroxidase; Guanidines; Leukocytes; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pancreatic Elastase; Proteolysis; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Reactive Nitrogen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tyrosine | 2012 |
Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease.
Topics: Animals; Arterial Pressure; Cell Hypoxia; Creatinine; Cyclic N-Oxides; Disease Progression; Glucose Transporter Type 1; Heme Oxygenase (Decyclizing); Hemodynamics; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Kidney Diseases; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Polycystic Kidney Diseases; Rats; Rats, Inbred Lew; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine; Vascular Endothelial Growth Factor A | 2012 |
Long-term binge and escalating ethanol exposure causes necroinflammation and fibrosis in rat liver.
Topics: Animals; Binge Drinking; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Ethanol; Hypoxia-Inducible Factor 1; Inflammation; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Necrosis; Nitric Oxide Synthase Type II; Oxidative Stress; Procollagen; Rats; Rats, Wistar; Tyrosine | 2013 |
Opening of chloride channels by 1α,25-dihydroxyvitamin D3 contributes to photoprotection against UVR-induced thymine dimers in keratinocytes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Cells, Cultured; Chloride Channels; DNA Damage; Dose-Response Relationship, Drug; Humans; Keratinocytes; Male; Pyrimidine Dimers; Tumor Suppressor Protein p53; Tyrosine; Ultraviolet Rays; Vitamin D | 2013 |
Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase.
Topics: Cytochrome P-450 CYP3A; Dithionite; Humans; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Peptides; Peroxynitrous Acid; Protein Conformation; Tyrosine | 2012 |
Previous exposure to cigarette smoke aggravates experimental cyclosporine-induced nephrotoxicity.
Topics: Actins; Animals; Cyclosporine; Disease Models, Animal; Drug Synergism; Fibrosis; Glomerular Filtration Rate; Hematocrit; Hemodynamics; Humans; Immunosuppressive Agents; Kidney; Male; Nephritis, Interstitial; Rats; Rats, Wistar; Smoking; Tyrosine; Vimentin | 2012 |
Characterization of nitrotyrosine as a biomarker for arthritis and joint injury.
Topics: Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Arthritis, Rheumatoid; Case-Control Studies; Chemokines; Chondrocalcinosis; Cytokines; Female; Humans; Male; Matrix Metalloproteinases, Secreted; Menisci, Tibial; Nitrates; Osteoarthritis, Knee; Synovial Fluid; Tibial Meniscus Injuries; Tyrosine | 2013 |
INF-β1b therapy modulates L-arginine and nitric oxide metabolism in patients with relapse remittent multiple sclerosis.
Topics: Adult; Arginase; Arginine; Biomarkers; Drug Monitoring; Female; Follow-Up Studies; Humans; Inflammation; Interferon beta-1b; Interferon-beta; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nitrates; Nitric Oxide; Nitrites; Nitroso Compounds; Severity of Illness Index; Sulfhydryl Compounds; Tyrosine; Young Adult | 2012 |
The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Carrier Proteins; Disease Models, Animal; E-Selectin; Endothelial Cells; Evans Blue; Functional Laterality; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 9; Neoplasm Proteins; Neurons; Neuroprotective Agents; NF-kappaB-Inducing Kinase; Nitric Oxide; Nitrites; Nucleocytoplasmic Transport Proteins; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Sprague-Dawley; S-Nitrosoglutathione; Statistics, Nonparametric; Time Factors; Tyrosine; Zonula Occludens-1 Protein | 2012 |
Plasma 3-nitrotyrosine estimates the reperfusion-induced cerebrovascular stress, whereas matrix metalloproteinases mainly reflect plasma activity: a study in patients treated with thrombolysis or endovascular recanalization.
Topics: Adult; Aged; Brain Ischemia; Cerebral Angiography; Diffusion Magnetic Resonance Imaging; Endovascular Procedures; Female; Humans; Male; Matrix Metalloproteinase 2; Middle Aged; Oxidative Stress; Reperfusion Injury; Thrombolytic Therapy; Time Factors; Tomography, X-Ray Computed; Tyrosine; Ultrasonography, Doppler, Transcranial | 2012 |
Partial outlet obstruction in rabbits: duration versus severity.
Topics: Animals; Dinitrophenols; Muscle Contraction; Protein Carbonylation; Rabbits; Time Factors; Tyrosine; Urinary Bladder; Urinary Bladder Neck Obstruction | 2013 |
Effects of alpha-lipoic acid on associative and spatial memory of sham-irradiated and 56Fe-irradiated C57BL/6J male mice.
Topics: Animals; Antioxidants; Brain; Conditioning, Psychological; Cranial Irradiation; Dentate Gyrus; Iron; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Radiation Injuries, Experimental; Thioctic Acid; Tyrosine | 2013 |
Up-regulation of heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability.
Topics: Animals; Blotting, Western; Brain Ischemia; Dependovirus; Genetic Therapy; Genetic Vectors; Heme Oxygenase-1; Infarction, Middle Cerebral Artery; Male; Nervous System Diseases; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxides; Tyrosine; Up-Regulation | 2013 |
Increased circulating levels of 3-nitrotyrosine autoantibodies: marker for or maker of cardiovascular disease?
Topics: Coronary Artery Disease; Epitopes; Female; Humans; Immunoglobulins; Male; Tyrosine | 2012 |
Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease.
Topics: Aged; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Epitopes; Female; Humans; Immune System; Immunoglobulins; Male; Middle Aged; Tyrosine | 2012 |
Nitrosative stress: a hallmark of the junctional inflammation in cutaneous lupus erythematosus.
Topics: Humans; Immunohistochemistry; Lupus Erythematosus, Cutaneous; Oxidative Stress; Tyrosine | 2013 |
Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes.
Topics: Aconitate Hydratase; Animals; Citric Acid Cycle; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; Ganglia, Spinal; Glycolysis; Lipid Peroxidation; Male; Mice; Mice, Mutant Strains; Neurons; Oxidative Stress; Peripheral Nervous System; Receptors, Leptin; Sciatic Nerve; Sural Nerve; Tyrosine | 2013 |
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Encephalitis; Fluoresceins; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; NADPH Oxidases; Neuroglia; Neuroprotective Agents; Neurotransmitter Agents; Nitric Oxide Synthase Type II; Organic Chemicals; Tyrosine; Tyrosine 3-Monooxygenase | 2012 |
The importance of L-arginine metabolism modulation in diabetic patients with distal symmetric polyneuropathy.
Topics: Aged; Arginase; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrodiagnosis; Female; Fructosamine; Glycated Hemoglobin; Humans; Male; Methylation; Middle Aged; Nitrates; Nitrites; S-Nitrosothiols; Tyrosine | 2013 |
Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation.
Topics: Animals; Apoptosis Inducing Factor; Blood Pressure; Cardiopulmonary Bypass; Catechin; Creatinine; Heart Rate; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Poly Adenosine Diphosphate Ribose; Protective Agents; Swine; Tyrosine; Urea | 2013 |
Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.
Topics: Acetylcholine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Hemodynamics; NADPH Oxidases; Nitric Oxide; PPAR gamma; Pulmonary Circulation; Pulmonary Wedge Pressure; rac1 GTP-Binding Protein; Rosiglitazone; Sheep; Superoxide Dismutase; Thiazolidinediones; Tyrosine; Vascular Resistance | 2013 |
Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Kidney Cortex; Male; Mitochondrial Proteins; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
Cerebral protection during controlled hypoperfusion in a piglet model: comparison of moderate (25°C) versus deep (18°C) hypothermia at various flow rates using intraoperative measurements and ex vivo investigation.
Topics: Animals; Animals, Newborn; Biomarkers; Cardiopulmonary Bypass; Cerebrovascular Circulation; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Circulatory Arrest, Deep Hypothermia Induced; Female; Hemodynamics; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Lactic Acid; Malondialdehyde; Models, Animal; Monitoring, Intraoperative; Oxygen; Perfusion; Swine; Time Factors; Tyrosine | 2013 |
Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats.
Topics: Allyl Compounds; Animals; Apoptosis; Cardiomyopathies; Caspase 3; Cell Survival; Diabetes Mellitus, Experimental; Disulfides; Garlic; Heart; Male; Mitochondria; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Death Domain; Signal Transduction; Sulfides; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2013 |
Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
Topics: Age Factors; Aging; Animals; Antioxidants; Aorta; Carotid Arteries; Collagen Type I; Curcumin; Dose-Response Relationship, Drug; Elastin; Endothelium, Vascular; Glycation End Products, Advanced; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pulse Wave Analysis; Superoxide Dismutase; Superoxides; Tyrosine; Vascular Stiffness; Vasodilation; Vasodilator Agents | 2013 |
Delayed preconditioning prevents ischemia/reperfusion-induced endothelial injury in rats: role of ROS and eNOS.
Topics: Acetylcholine; Animals; Blotting, Western; DNA Primers; Endothelial Cells; Fluorescent Antibody Technique; Immunohistochemistry; Ischemic Preconditioning; Male; Malondialdehyde; Microscopy, Electron, Transmission; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinase; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tyrosine | 2013 |
Local gene delivery of heme oxygenase-1 by adeno-associated virus into osteoarthritic mouse joints exhibiting synovial oxidative stress.
Topics: Animals; Bone Remodeling; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Heme Oxygenase-1; Hydrogen Peroxide; In Vitro Techniques; Injections, Intra-Articular; Joints; Male; Membrane Proteins; Mice; Mice, Inbred CBA; Mice, Inbred Strains; Mice, Mutant Strains; Osteoarthritis; Oxidative Stress; Synovial Membrane; Transduction, Genetic; Tyrosine | 2013 |
Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects.
Topics: Free Radicals; Lipid Peroxidation; Models, Molecular; Superoxides; Tyrosine | 2013 |
Periodontal disease, periodontal treatment and systemic nitric oxide in dogs.
Topics: Animals; Dog Diseases; Dogs; Female; Hemoglobins; Male; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Periodontal Diseases; Time Factors; Tyrosine | 2013 |
Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage.
Topics: Apoptosis; Blotting, Western; Caspase 3; Catalase; Cell Death; Cell Line, Tumor; Cyperus; Cytoprotection; DNA Damage; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Humans; Lipid Peroxidation; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rhizome; Superoxide Dismutase; Tyrosine | 2013 |
A plasma oxidative stress global index in early stages of chronic venous insufficiency.
Topics: Adult; Advanced Oxidation Protein Products; Biomarkers; Case-Control Studies; Catalase; Chronic Disease; Disease Progression; Early Diagnosis; Female; Glutathione; Humans; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peroxidase; Predictive Value of Tests; Protein Carbonylation; Sulfhydryl Compounds; Tyrosine; Ultrasonography, Doppler, Color; Uric Acid; Veins; Venous Insufficiency; Xanthine Oxidase | 2013 |
Hydrogen sulfide inhibits oxidative stress in lungs from allergic mice in vivo.
Topics: Animals; Catalase; Female; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Sulfide; Hypersensitivity; Leukocytes; Lung; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase; Oxidative Stress; Sulfides; Superoxide Dismutase; Thiobarbiturates; Tyrosine | 2013 |
Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury.
Topics: Animals; Biomarkers; Cyclic GMP; Enzyme Inhibitors; Immunohistochemistry; Infusions, Parenteral; Kidney; Lysine; Male; Nephrectomy; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Rutin; Tyrosine | 2013 |
Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis?
Topics: Animals; Autophagy; Cell Proliferation; DNA Repair; Kidney; Mice; Mice, Knockout; Mitochondrial Turnover; Models, Animal; Nephrons; Oxidative Stress; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2013 |
Temporal patterns of tyrosine nitration in embryo heart development.
Topics: Animals; Female; Heart; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2013 |
Electrochemical nitration of myoglobin at tyrosine 103: structure and stability.
Topics: Animals; Circular Dichroism; Electrochemical Techniques; Heme; Horses; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Muscle, Skeletal; Myoglobin; Nuclear Magnetic Resonance, Biomolecular; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Tyrosine | 2013 |
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes.
Topics: Aldehydes; Amino Acid Sequence; Cells, Cultured; Dose-Response Relationship, Radiation; Erythrocyte Membrane; Erythrocytes; Gamma Rays; Hemoglobins; Hemolysis; Humans; Hydrogen Peroxide; Methionine; Molecular Sequence Data; Nitrites; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan; Tyrosine | 2013 |
Combination therapy with losartan and pioglitazone additively reduces renal oxidative and nitrative stress induced by chronic high fat, sucrose, and sodium intake.
Topics: Animals; Body Weight; Diet, High-Fat; Dietary Sucrose; Drug Synergism; Drug Therapy, Combination; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Kidney; Losartan; Male; Malondialdehyde; NADPH Oxidases; Nitrosation; Oxidation-Reduction; Oxidative Stress; Pioglitazone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium, Dietary; Superoxide Dismutase; Thiazolidinediones; Tyrosine | 2012 |
Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Animals; Apoptosis; Boron Compounds; Calcium; Calpain; Caspase 3; Caspase 9; Cell Line, Tumor; DNA, Mitochondrial; Dopamine Agents; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hydro-Lyases; Mice; Mitochondria; Neuroblastoma; Peroxiredoxins; Reactive Oxygen Species; RNA, Small Interfering; Subcellular Fractions; Transfection; Tyrosine | 2013 |
Chemotherapy modulates the biological activity of breast cancer patients plasma: the protective properties of black chokeberry extract.
Topics: Adult; Antioxidants; Biomarkers; Blood Platelets; Breast Neoplasms; Case-Control Studies; Cyclophosphamide; Doxorubicin; Female; Fruit; Hemostasis; Humans; Lipid Peroxidation; Middle Aged; Oxidative Stress; Photinia; Plant Extracts; Poland; Tyrosine | 2013 |
Sodium-glucose cotransporter inhibition prevents oxidative stress in the kidney of diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Immunohistochemistry; Kidney; Male; Oxidative Stress; Phlorhizin; Rats; Rats, Wistar; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Superoxide Dismutase; Tyrosine | 2012 |
Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Collagen Type I; Dioxoles; Disease Models, Animal; Down-Regulation; Fibrosis; Heart; Hypertension; Hypertrophy, Left Ventricular; Lignans; Male; Malondialdehyde; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Transforming Growth Factor beta1; Tyrosine; Ventricular Remodeling | 2013 |
Changes in nitrosative stress biomarkers in swine intestine following dietary intervention with verbascoside.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Animal Feed; Animals; Antioxidants; Biomarkers; Deoxyguanosine; Diet; Diet Therapy; Duodenum; Free Radicals; Glucosides; Jejunum; Male; Nitrosation; Oxidative Stress; Phenols; Swine; Tyrosine | 2013 |
Phosphorylation of myocardial eNOS is altered in patients suffering from type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Diabetes Mellitus, Type 2; Dinoprost; Humans; Middle Aged; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Tyrosine | 2013 |
Chronic Tempol treatment restores pharmacological preconditioning in the senescent rat heart.
Topics: Aging; Animals; Antioxidants; Calcium; Cardiotonic Agents; Cyclic N-Oxides; Heart; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitochondria; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Inbred F344; Spin Labels; Superoxide Dismutase; Tyrosine | 2013 |
Increased oxidative stress may lead to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rat.
Topics: Adaptation, Physiological; Animals; Cytoprotection; Ethanol; Gastric Mucosa; Glutathione; Histidine; Hypertension, Portal; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tyrosine | 2013 |
Conversion of 3-nitrotyrosine to 3-aminotyrosine residues facilitates mapping of tyrosine nitration in proteins by electrospray ionization-tandem mass spectrometry using electron capture dissociation.
Topics: Amino Acid Sequence; Biochemical Phenomena; Chromatography, Liquid; Humans; Models, Chemical; Molecular Sequence Data; Nitro Compounds; Peptide Fragments; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine; Ubiquitin | 2012 |
Notch-dependent regulation of the ischemic vasodilatory response--brief report.
Topics: Animals; Cell Adhesion Molecules; Collateral Circulation; Disease Models, Animal; Endothelium, Vascular; Femoral Artery; Hindlimb; Ischemia; Laser-Doppler Flowmetry; Ligation; Mice; Mice, Transgenic; Microfilament Proteins; Muscle, Skeletal; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoproteins; Phosphorylation; Receptors, Notch; Regional Blood Flow; Signal Transduction; Transcription Factors; Tyrosine; Vasodilation | 2013 |
The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-αR1: a comparison with infliximab treatment.
Topics: Acute Kidney Injury; Animals; Antibodies, Monoclonal; Apoptosis; Biomarkers; Cell Adhesion Molecules; Gene Deletion; Gene Expression Regulation; Gene Knockout Techniques; Inflammation; Infliximab; Interleukin-1beta; Kidney; Lipid Peroxidation; Male; Mice; Neutrophil Infiltration; Oxidative Stress; Receptors, Tumor Necrosis Factor, Type I; Reperfusion Injury; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Amniotic fluid oxidative and nitrosative stress biomarkers correlate with fetal chronic hypoxia in diabetic pregnancies.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Amniocentesis; Amniotic Fluid; Biomarkers; Birth Weight; Chromatography, High Pressure Liquid; Chronic Disease; Deoxyguanosine; Diabetes Mellitus, Type 1; Diabetes, Gestational; Erythropoietin; Female; Fetal Hypoxia; Gestational Age; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Immunoassay; Infant, Newborn; Insulin; Male; Nitrosation; Oxidative Stress; Pilot Projects; Pregnancy; Pregnancy in Diabetics; Tandem Mass Spectrometry; Tyrosine; Young Adult | 2013 |
Rapid auxin-induced nitric oxide accumulation and subsequent tyrosine nitration of proteins during adventitious root formation in sunflower hypocotyls.
Topics: Helianthus; Hypocotyl; Indoleacetic Acids; Nitric Oxide; Nitrosation; Plant Proteins; Plant Roots; Signal Transduction; Tyrosine; Xylem | 2013 |
High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis.
Topics: Adult; Aged; Apolipoprotein A-I; Arthritis, Rheumatoid; Cardiovascular Diseases; Case-Control Studies; Cholesterol; Female; Halogenation; Humans; Lipoproteins, HDL; Male; Middle Aged; Oxidation-Reduction; Peptide Mapping; Peroxidase; Tandem Mass Spectrometry; Tyrosine | 2013 |
Oxidative and nitrosative stress and apoptosis in oral mucosa cells after ex vivo exposure to lead and benzo[a]pyrene.
Topics: Adolescent; Adult; Apoptosis; Benzo(a)pyrene; Caspase 3; Dinoprost; Environmental Pollutants; Female; Humans; In Vitro Techniques; Lead; Male; Middle Aged; Mouth Mucosa; Oxidative Stress; Smoking; Tyrosine; Young Adult | 2013 |
Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetophenones; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antioxidants; Biomarkers; Corticosterone; Deoxyguanosine; Female; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Mutation; NADPH Oxidases; Neurosecretory Systems; Oxidative Stress; Pituitary-Adrenal System; Psychosocial Deprivation; Psychotic Disorders; Rats; Rats, Wistar; Restraint, Physical; Saliva; Social Isolation; Stress, Psychological; Tyrosine | 2013 |
Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Western; Chronic Disease; Dinoprost; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Endothelin-1; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Male; NF-kappa B; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factor AP-1; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases.
Topics: Aldehydes; Animals; Cell Death; DNA Fragmentation; Ion Channel Gating; Lipid Peroxidation; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrosation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction; TRPV Cation Channels; Tyrosine; Up-Regulation | 2013 |
Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade.
Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Biphenyl Compounds; Breath Tests; Disease Models, Animal; Female; Fibrosis; Hypochlorous Acid; Injections, Intradermal; Irbesartan; Lung; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidants; Pulmonary Fibrosis; Scleroderma, Systemic; Skin; Tetrazoles; Tyrosine | 2013 |
Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult.
Topics: Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Injections, Intraperitoneal; Iridoid Glucosides; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2013 |
NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Imines; Lymphoma, T-Cell; MicroRNAs; Nitric Oxide; Nitric Oxide Synthase Type II; Protein-Tyrosine Kinases; Signal Transduction; STAT3 Transcription Factor; Tumor Suppressor Proteins; Tyrosine; Up-Regulation | 2013 |
Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma.
Topics: Aged; Antigens, Differentiation, T-Lymphocyte; Blood Vessels; Carcinoma, Merkel Cell; CD8-Positive T-Lymphocytes; E-Selectin; Female; Humans; Immunotherapy, Adoptive; Male; Membrane Glycoproteins; Middle Aged; Skin; Skin Neoplasms; Tyrosine | 2013 |
Evaluation of inflammatory response to acute ischemia using near-infrared fluorescent reactive oxygen sensors.
Topics: Animals; Biosensing Techniques; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Fluorescence; Fluorescent Dyes; Hindlimb; Immunohistochemistry; Inflammation; Ischemia; Mice; Mice, Inbred C57BL; Muscles; Reactive Oxygen Species; Spectroscopy, Near-Infrared; Tissue Distribution; Tyrosine | 2013 |
Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis.
Topics: Acids; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Ionic Liquids; Ions; Static Electricity; Tyrosine | 2013 |
Bioinformatics analysis reveals biophysical and evolutionary insights into the 3-nitrotyrosine post-translational modification in the human proteome.
Topics: Amino Acid Sequence; Biophysical Phenomena; Computational Biology; Evolution, Molecular; Humans; Mass Spectrometry; Molecular Sequence Annotation; Protein Processing, Post-Translational; Proteins; Proteome; Tyrosine | 2013 |
Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression.
Topics: Amyloid beta-Protein Precursor; Cell Line, Tumor; Cell Survival; Chlorides; GAP-43 Protein; Humans; Hydrogen Peroxide; Neurons; Oxidative Stress; Protein Structure, Tertiary; Protein Unfolding; RNA, Messenger; Transcription, Genetic; Tumor Suppressor Protein p53; Tyrosine; Zinc Compounds | 2013 |
Quercetin prevents protein nitration and glycolytic block of proliferation in hydrogen peroxide insulted cultured neuronal precursor cells (NPCs): Implications on CNS regeneration.
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Caspase 3; Catalase; Cell Proliferation; Cells, Cultured; Cerebral Ventricles; DNA Fragmentation; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Glutathione; Glycolysis; Hydrogen Peroxide; L-Lactate Dehydrogenase; Male; Membrane Potential, Mitochondrial; Neural Stem Cells; Nitrites; Oxidants; Poly(ADP-ribose) Polymerases; Quercetin; Rats; Tyrosine | 2013 |
Lack of cell stress markers in fibrous cap cells in the left main coronary artery.
Topics: Animals; Biomarkers; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endothelial Cells; Fibrosis; Heat-Shock Proteins; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type II; Plaque, Atherosclerotic; Rabbits; Stress, Physiological; Transcription Factor CHOP; Tyrosine | 2013 |
Sfrp5 correlates with insulin resistance and oxidative stress.
Topics: Adaptor Proteins, Signal Transducing; Adiponectin; Animals; Body Mass Index; Clinical Trials as Topic; Coffee; Dinoprost; Eye Proteins; Humans; Insulin; Insulin Resistance; Membrane Proteins; Mice; Middle Aged; Models, Animal; Obesity; Oxidative Stress; Proto-Oncogene Proteins; Statistics as Topic; Tyrosine; Wnt Proteins; Wnt Signaling Pathway; Wnt-5a Protein | 2013 |
MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.
Topics: Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Disease Models, Animal; Down-Regulation; Mice; Mice, Inbred C57BL; MicroRNAs; Oligonucleotide Array Sequence Analysis; Orexin Receptors; Oxidative Stress; Real-Time Polymerase Chain Reaction; Receptors, Neuropeptide; Retina; RNA, Messenger; Transfection; Tyrosine | 2013 |
A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Diet, Ketogenic; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Movement Disorders; Muscle, Skeletal; Presenilin-1; Reaction Time; Tyrosine | 2013 |
May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?
Topics: Albumins; alpha-Synuclein; Biomarkers; Humans; Mass Spectrometry; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Tyrosine | 2013 |
[3-nitrotyrosine determination as nitrosative stress marker and health attitudes of medical students considering exposure to environmental tobacco smoke].
Topics: Adult; Alcohol Drinking; Biomarkers; Environmental Exposure; Environmental Monitoring; Feeding Behavior; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Reference Values; Smoking; Students, Medical; Surveys and Questionnaires; Tobacco Smoke Pollution; Tyrosine; Young Adult | 2012 |
Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374).
Topics: Animals; Coenzyme A-Transferases; Diabetes Mellitus, Experimental; Disease Models, Animal; Energy Metabolism; Heart Diseases; Male; Metallothionein; Mice; Mice, Inbred Strains; Mice, Transgenic; Myocardium; Nitrogen; Protein Structure, Tertiary; Superoxides; Tryptophan; Tyrosine | 2013 |
Atorvastatin withdrawal elicits oxidative/nitrosative damage in the rat cerebral cortex.
Topics: Animals; Atorvastatin; Cerebral Cortex; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide; Oxidation-Reduction; Pyrroles; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Superoxide Dismutase; Tyrosine | 2013 |
Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone.
Topics: Aldehydes; Analysis of Variance; Animals; Blood-Brain Barrier; Cell Count; Disease Models, Animal; Hydrogen Peroxide; Locomotion; Male; Metalloporphyrins; Methylprednisolone; Microdialysis; Nervous System Diseases; Neuroprotective Agents; Oxidative Stress; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries; Time Factors; Tyrosine | 2013 |
Pinacidil stimulates osteoblast function in osteoblastic MC3T3-E1 cells.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Antimycin A; Calcium; Cell Differentiation; Collagen; Cytokines; Dose-Response Relationship, Drug; Ion Channel Gating; Mice; Osteoblasts; Osteocalcin; Pinacidil; Potassium Channels; RANK Ligand; Reactive Oxygen Species; Tyrosine | 2013 |
Preconcentration of 3-nitrotyrosine in urine by transient isotachophoresis in MEKC.
Topics: Electrophoresis, Capillary; Humans; Isotachophoresis; Tyrosine | 2013 |
Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: consequences of treatment with antioxidant pyridoindole.
Topics: Aging; Aldehydes; Animals; Antioxidants; Cerebral Cortex; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Heart Ventricles; Indoles; Kidney; Lens, Crystalline; Liver; Male; Oxidation-Reduction; Oxidative Stress; Proteins; Pyridines; Rats; Rats, Wistar; Tyrosine | 2013 |
EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee.
Topics: Aged; Animals; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Ginkgo biloba; Humans; Interleukin-1beta; Lipopolysaccharides; Male; Middle Aged; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis, Knee; Plant Extracts; Rats; Rats, Wistar; Toll-Like Receptor 4; Tyrosine | 2013 |
The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Caspase 3; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Glutathione; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Necrosis; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazolidines; Tyrosine | 2013 |
The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis.
Topics: Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Bone Morphogenetic Protein Receptors, Type II; Carotid Stenosis; Chemokine CCL2; DEAD-box RNA Helicases; Disease Progression; Gene Expression Regulation; Interleukin-6; Macrophage Activation; Macrophages; Mice; Mice, Knockout; MicroRNAs; Nitric Oxide Synthase Type II; Oligonucleotides; Proto-Oncogene Proteins c-akt; Ribonuclease III; RNA, Antisense; Signal Transduction; Tyrosine; Up-Regulation; Vasculitis | 2013 |
Dependence of vascular damage on higher frequency components in the rat-tail model.
Topics: Animals; Arteries; Disease Models, Animal; Hand-Arm Vibration Syndrome; Male; Rats; Rats, Sprague-Dawley; Tyrosine; Vacuoles; Vibration | 2013 |
The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fluoresceins; Glutamic Acid; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microinjections; Neurotoxicity Syndromes; Neurotoxins; Nitric Oxide; Octreotide; Somatostatin; Tyrosine; Tyrosine 3-Monooxygenase | 2013 |
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.
Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2013 |
Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.
Topics: Aging; Animals; Biomarkers; Blotting, Western; Immunohistochemistry; Memory; Mice; Microscopy, Electron; Nitric Oxide; Olfactory Bulb; Oxidative Stress; Smell; Tyrosine | 2013 |
[Effect of nitrotyrosine on renal expressions of NF-κB, MCP-1 and TGF-β1 in rats with diabetic nephropathy].
Topics: Animals; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Tyrosine | 2013 |
Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis.
Topics: Amyloid beta-Peptides; Apoptosis; Butadienes; Cell Line; Cell Survival; Endothelial Cells; Ginsenosides; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MAP Kinase Signaling System; Mifepristone; Nitric Oxide; Nitriles; Peptide Fragments; Protective Agents; Reactive Oxygen Species; Receptors, Glucocorticoid; Tyrosine | 2013 |
Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice.
Topics: Animals; Brain Infarction; Brain Injuries; Cerebral Cortex; Gene Expression Regulation; Glial Fibrillary Acidic Protein; I-kappa B Proteins; Inflammation; Interleukin-1beta; MAP Kinase Kinase 4; Mice; Mice, Knockout; Nerve Tissue Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Toll-Like Receptor 4; Tryptases; Tyrosine | 2013 |
Radiation mitigating properties of the lignan component in flaxseed.
Topics: Animal Feed; Animals; Bronchoalveolar Lavage Fluid; Butylene Glycols; Cytokines; Female; Fibrosis; Flax; Glucosides; Kaplan-Meier Estimate; Lignans; Lung; Lung Injury; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxygen; Phytotherapy; Radiation Injuries, Experimental; Radiation Pneumonitis; Radiation-Protective Agents; Seeds; Survival Rate; Time Factors; Transforming Growth Factor beta1; Tyrosine | 2013 |
Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cerebellum; Cysteine; DNA Methylation; Glutathione; Male; Mice; Mice, Inbred MRL lpr; Oxidation-Reduction; Oxidative Stress; Trichloroethylene; Tyrosine | 2013 |
Inhibition of UVB-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, ERK/NF-kB signaling pathway and apoptosis, in SKH-1 mice.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Female; Grape Seed Extract; MAP Kinase Signaling System; Mice; Mice, Hairless; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Radiation-Protective Agents; Signal Transduction; Skin; Skin Diseases; Tyrosine; Ultraviolet Rays | 2013 |
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
Topics: Animals; Cattle; Cytochrome P-450 Enzyme System; Humans; Intramolecular Oxidoreductases; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Sf9 Cells; Spodoptera; Sulfhydryl Compounds; Tyrosine | 2013 |
Chronic oxidative-nitrosative stress impairs coronary vasodilation in metabolic syndrome model rats.
Topics: Animals; Azoles; Coronary Vessels; Cyclic N-Oxides; Disease Models, Animal; Down-Regulation; Free Radical Scavengers; Guanylate Cyclase; Heart; Isoindoles; Male; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrogen; Organoselenium Compounds; Oxidative Stress; Phosphorylation; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Spin Labels; Superoxides; Tyrosine; Vasodilation | 2013 |
The effect of high-dose insulin analog initiation therapy on lipid peroxidation products and oxidative stress markers in type 2 diabetic patients.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dinoprost; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Insulin; Lipid Peroxidation; Male; Metformin; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Protein Carbonylation; Sulfonylurea Compounds; Tyrosine | 2013 |
Therapeutic effect of MG132 on the aortic oxidative damage and inflammatory response in OVE26 type 1 diabetic mice.
Topics: Albuminuria; Animals; Aorta; Blood Pressure; Diabetes Mellitus, Experimental; Hyperglycemia; Leupeptins; Mice; Mice, Transgenic; NF-E2-Related Factor 2; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2013 |
High-fat, low-carbohydrate diet alters myocardial oxidative stress and impairs recovery of cardiac function after ischemia and reperfusion in obese rats.
Topics: Adiponectin; Animals; Antioxidants; Catalase; Diet, Carbohydrate-Restricted; Diet, High-Fat; DNA Copy Number Variations; DNA, Mitochondrial; Glycogen; Insulin; Male; Mitochondrial Turnover; Myocardial Reperfusion Injury; Myocardium; NADPH Oxidase 4; NADPH Oxidases; Obesity; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine; Weight Loss; Xanthine Oxidase | 2013 |
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Axons; Dietary Supplements; Disease Models, Animal; Disease Progression; Eicosapentaenoic Acid; Female; Humans; Lipid Metabolism; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Motor Neurons; Mutant Proteins; Neuroglia; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Survival Analysis; Tyrosine; Vacuoles | 2013 |
Peroxynitrite induced structural changes result in the generation of neo-epitopes on human serum albumin.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Epitopes; Female; Humans; Immunoglobulin G; Injections, Intramuscular; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Protein Carbonylation; Protein Conformation; Rabbits; Serum Albumin; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2013 |
Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Benzoates; Biomarkers; Blotting, Western; Deoxyguanosine; Diabetes Mellitus, Experimental; DNA Damage; Germ Cells; Immunoenzyme Techniques; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sperm Count; Telmisartan; Tyrosine | 2013 |
In situ expression of heat-shock proteins and 3-nitrotyrosine in brains of young rats exposed to a WiFi signal in utero and in early life.
Topics: Animals; Brain; Embryo, Mammalian; Female; Gene Expression Regulation; Heat-Shock Proteins; Pregnancy; Rats; Rats, Wistar; Time Factors; Tyrosine; Wireless Technology | 2013 |
Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice.
Topics: Animals; Aorta; Apolipoproteins E; Apoptosis; Atherosclerosis; Blood Proteins; Body Weight; Collagen Type I; Enzyme Inhibitors; Farnesyltranstransferase; Female; Kidney Failure, Chronic; Liver; Macrophages; Mevalonic Acid; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Prenylation; Quinolones; Random Allocation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine; Uremia; Vascular Calcification | 2013 |
Cardioprotection by farnesol: role of the mevalonate pathway.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Survival; Cells, Cultured; Cholesterol; Dolichols; Farnesol; Male; Mevalonic Acid; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Protein Prenylation; Rats; Rats, Wistar; Tyrosine; Ubiquinone | 2013 |
Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Pressure; Drug Synergism; Endothelium, Vascular; Losartan; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Pioglitazone; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Systole; Thiazolidinediones; Tyrosine; Vasoconstriction; Vasodilation | 2014 |
Oxidative effect of several intravenous iron complexes in the rat.
Topics: Administration, Intravenous; Animals; Dinitrobenzenes; Dose-Response Relationship, Drug; Ferric Compounds; Ferric Oxide, Saccharated; Ferrosoferric Oxide; Glucaric Acid; Iron-Dextran Complex; Maltose; Oxidative Stress; Rats; Tissue Distribution; Tyrosine | 2013 |
Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor.
Topics: Animals; Antioxidants; Chronic Disease; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidases; Oxidative Stress; Pulmonary Artery; Reactive Oxygen Species; Scavenger Receptors, Class E; Signal Transduction; Tyrosine; Up-Regulation; Ventricular Function, Right; Ventricular Pressure | 2013 |
Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder.
Topics: Bipolar Disorder; Case-Control Studies; Electron Transport Complex I; Electron Transport Complex III; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Lipid Peroxidation; Male; Middle Aged; Mitochondria; Oxidation-Reduction; Oxidative Stress; Prefrontal Cortex; Schizophrenia; Superoxide Dismutase; Synaptosomes; Tyrosine | 2013 |
Therapeutic time window for edaravone treatment of traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain Injuries; Disease Models, Animal; Edaravone; Free Radical Scavengers; Japan; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Reactive Oxygen Species; Tyrosine | 2013 |
L-arginine-NO-cGMP signalling pathway in pancreatitis.
Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Cyclic GMP; Female; Fluorescent Antibody Technique; Guanosine; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pancreas; Pancreatitis; Signal Transduction; Tyrosine | 2013 |
Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy.
Topics: Adult; Aged; Analysis of Variance; Automobile Driving; Biomarkers; Chemokines; Cyclic GMP; Flicker Fusion; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Middle Aged; Nitric Oxide; Psychometrics; Tyrosine | 2013 |
A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes.
Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Glutathione; Glutathione Peroxidase; Keratin-18; Liver; Male; Malondialdehyde; Mitochondria, Liver; Mitochondrial Proteins; Nitroso Compounds; Oxidative Phosphorylation; Oxidative Stress; Phospholipids; Rats; Rats, Wistar; Silybin; Silymarin; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances; Thioredoxins; Time Factors; Tyrosine; Vitamin E | 2013 |
Chronic administration of methylmalonate on young rats alters neuroinflammatory markers and spatial memory.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Biomarkers; Cerebral Cortex; Gene Expression Regulation; Humans; Inflammation Mediators; Interleukin-1beta; Memory Disorders; Methylmalonic Acid; Neuroimmunomodulation; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Spatial Behavior; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice.
Topics: Animals; Blotting, Western; Lipid Peroxidation; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Muscle Contraction; Muscle, Skeletal; Muscular Atrophy; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2013 |
Oxidative stress status in umbilical cord blood from neonates born to mothers with atopic asthma.
Topics: Adult; Asthma; Basophils; Female; Fetal Blood; Glutathione Peroxidase; Humans; Hypersensitivity, Immediate; Infant, Newborn; Interleukin-4; Oxidative Stress; Pregnancy; Pregnancy Complications; Tyrosine | 2014 |
Effects of balanced hydroxyethyl starch solutions on gut mucosal microcirculation and exhaled nitric oxide in septic rats: A randomised, animal study.
Topics: Animals; Arterioles; Capillaries; Disease Models, Animal; Erythrocytes; Hydroxyethyl Starch Derivatives; Inflammation; Intestines; Male; Microcirculation; Nitric Oxide; Oxidative Stress; Plasma Substitutes; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Solanum tuberosum; Tyrosine; Zea mays | 2013 |
Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats.
Topics: Aldehydes; Animals; Arterioles; Behavior, Animal; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glycation End Products, Advanced; Guanidines; Male; Nerve Fibers; Nitrates; Pain Measurement; Pyruvaldehyde; Rats; Rats, Wistar; Reduced Folate Carrier Protein; Sciatic Nerve; Skin; Sulfones; Superoxides; Tyrosine | 2013 |
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.
Topics: Aged; Alcohol Oxidoreductases; Animals; Biopterins; Chromatography, High Pressure Liquid; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; GTP Cyclohydrolase; Humans; Hypertension, Pulmonary; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Pulmonary Fibrosis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Tyrosine | 2013 |
Mitochondria-targeted antioxidant peptide SS31 protects the retinas of diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Animals; Antioxidants; Blood Glucose; Blood-Retinal Barrier; Body Weight; Capillaries; Claudin-5; Deoxyguanosine; Diabetes Mellitus, Experimental; Endoplasmic Reticulum; Male; Mitochondria; Occludin; Oligopeptides; Oxidative Stress; Protective Agents; Protein Transport; Rats; Rats, Sprague-Dawley; Retina; Signal Transduction; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Antioxidative effects of extracts from Trifolium species on blood platelets exposed to oxidative stress.
Topics: Antioxidants; Blood Platelets; Cells, Cultured; Humans; Hydrogen Peroxide; Lipid Peroxidation; Oxidants; Oxidative Stress; Peroxynitrous Acid; Plant Components, Aerial; Plant Extracts; Thiobarbituric Acid Reactive Substances; Trifolium; Tyrosine | 2013 |
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease.
Topics: Acute-Phase Proteins; Animals; Biomarkers; Chemokines; Cytokines; Deoxycytidine; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Female; Helicobacter hepaticus; Helicobacter Infections; Humans; Immunity, Innate; Inflammatory Bowel Diseases; Male; Mice; Mice, Knockout; Tyrosine | 2013 |
Glycyrrhizin represses total parenteral nutrition-associated acute liver injury in rats by suppressing endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Bilirubin; Caspase 3; Cytokines; Endoplasmic Reticulum Stress; Glycyrrhizic Acid; Immunohistochemistry; Inflammation; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Liver; Liver Diseases; Male; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Parenteral Nutrition, Total; Phosphorylation; Rats, Sprague-Dawley; Reactive Nitrogen Species; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription Factor CHOP; Triglycerides; Tyrosine | 2013 |
The selective 5-LOX inhibitor 11-keto-β-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory cascades.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cardiotonic Agents; Caspase 3; Cyclooxygenase 2; DNA Fragmentation; Gene Expression Regulation; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Intercellular Adhesion Molecule-1; Lipoxygenase Inhibitors; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; NF-kappa B; Oxidation-Reduction; Peroxidase; Rats; Rats, Wistar; Triterpenes; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging.
Topics: Aging; Animals; Antioxidants; Apoptosis; Biomarkers; Blotting, Western; Brain; Flow Cytometry; Gene Expression; Glutathione; Heterozygote; Immunohistochemistry; In Situ Nick-End Labeling; Lipofuscin; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenotype; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2014 |
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.
Topics: Aldehydes; Angiotensin II Type 1 Receptor Blockers; Animals; Catalase; Citrate (si)-Synthase; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Imidazoles; Insulin Resistance; Male; Membrane Glycoproteins; Mitochondria, Heart; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; NF-E2-Related Factor 2; Obesity; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred OLETF; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Succinate Dehydrogenase; Superoxide Dismutase; Tetrazoles; Time Factors; Tyrosine | 2013 |
Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Inhalation; Aldehydes; Animals; Antioxidants; Cardiotonic Agents; Deoxyguanosine; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Gases; Hydrogen; Immunohistochemistry; Inhalation; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; Nitric Oxide; Oxidative Stress; Receptors, Cell Surface; Time Factors; Tyrosine; Ventricular Function, Left | 2013 |
Redox metabolism abnormalities in autistic children associated with mitochondrial disease.
Topics: Age Factors; Biomarkers; Child; Child Development Disorders, Pervasive; Female; Glutathione; Humans; Language Development; Male; Mitochondrial Diseases; Neuropsychological Tests; Oxidation-Reduction; Oxidative Stress; Tyrosine | 2013 |
Effect of rosiglitazone on liver structure and function in genetically diabetic Akita mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Cholesterol, Dietary; Diabetes Mellitus; Diet, High-Fat; Fatty Liver; Gene Expression; Genotype; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; PPAR gamma; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Triglycerides; Tyrosine | 2013 |
Characterization of a cellular denitrase activity that reverses nitration of cyclooxygenase.
Topics: Adaptation, Physiological; Animals; Cell Line; Cells, Cultured; Cyclooxygenase 1; Endothelium, Vascular; Humans; Macrophages; Mice; Mice, Inbred C57BL; Models, Animal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Oxidoreductases; Rats; Tyrosine | 2013 |
Protective effect of tryptophan against dextran sulfate sodium- induced experimental colitis.
Topics: Animal Feed; Animals; Antidepressive Agents, Second-Generation; Body Weight; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Female; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Random Allocation; Tryptophan; Tyrosine | 2013 |
Inhibition of nitric oxide mediated protein nitration: therapeutic implications in experimental radiculopathy.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hindlimb; Hyperalgesia; Intervertebral Disc; Ligation; Nitric Oxide; Nitric Oxide Synthase; Proteins; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Transplantation, Autologous; Tyrosine | 2013 |
Is the oxidant/antioxidant status altered in CADASIL patients?
Topics: Adult; Antioxidants; CADASIL; Case-Control Studies; Cysteine; Dipeptides; Female; Glutathione; Homocysteine; Humans; Male; Middle Aged; Oxidants; Oxidation-Reduction; Oxidative Stress; Tyrosine | 2013 |
Acetylcholine leads to signal transducer and activator of transcription 1 (STAT-1) mediated oxidative/nitrosative stress in human bronchial epithelial cell line.
Topics: Acetylcholine; Blotting, Western; Bronchi; Cells, Cultured; Cholinergic Agonists; Epithelial Cells; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; RNA, Small Interfering; STAT1 Transcription Factor; Tyrosine | 2013 |
Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Blueberry Plants; Cell Proliferation; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Drug Administration Schedule; Fruit; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Liver; Male; Necrosis; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2013 |
Oxidative stress in breath-hold divers after repetitive dives.
Topics: Adult; Biomarkers; Breath Holding; Diving; Humans; Hyperoxia; Hypoxia; Male; Nitric Oxide; Nitrites; Oxidative Stress; Sulfhydryl Compounds; Time Factors; Tyrosine | 2013 |
Paeoniflorin isolated from Paeonia lactiflora attenuates osteoblast cytotoxicity induced by antimycin A.
Topics: 3T3 Cells; Animals; Antimycin A; Antioxidants; Benzoates; Bridged-Ring Compounds; Cardiolipins; Cell Survival; Cytochromes c; Glucosides; Membrane Potential, Mitochondrial; Mice; Mitochondria; Monoterpenes; Osteoblasts; Oxidative Stress; Paeonia; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plant Extracts; Protective Agents; Reactive Oxygen Species; Thioredoxin-Disulfide Reductase; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Effects of tempol on endothelial and vascular dysfunctions and insulin resistance induced by a high-fat high-sucrose diet in the rat.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Mass Index; Cyclic N-Oxides; Diet, High-Fat; Dietary Sucrose; Endothelin-1; Endothelins; Endothelium, Vascular; Glucose; Glucose Transporter Type 4; Heart Rate; Hemodynamics; Inflammation; Insulin; Insulin Resistance; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Spin Labels; Tyrosine | 2013 |
The senescence-accelerated mouse prone-8 (SAM-P8) oxidative stress is associated with upregulation of renal NADPH oxidase system.
Topics: Aging; Animals; Gene Expression; Glutathione; Glutathione Disulfide; Kidney; Lipid Peroxidation; Male; Malondialdehyde; Membrane Glycoproteins; Mice; Mice, Transgenic; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Tyrosine; Up-Regulation | 2013 |
Electron flow through nitrotyrosinate in Pseudomonas aeruginosa azurin.
Topics: Azurin; Copper; Electron Transport; Models, Molecular; Organometallic Compounds; Protein Conformation; Pseudomonas aeruginosa; Tyrosine | 2013 |
Inhibition of peroxisomal hydroxypyruvate reductase (HPR1) by tyrosine nitration.
Topics: Amino Acid Sequence; Arabidopsis; Evolution, Molecular; Glutathione; Hydrogen Peroxide; Hydroxypyruvate Reductase; Models, Molecular; Molecular Sequence Data; Nitrates; Oxidation-Reduction; Peroxisomes; Peroxynitrous Acid; Pisum sativum; Plant Leaves; Proteome; Tyrosine | 2013 |
Neuroprotective effect of aqueous extract of Selaginella delicatula as evidenced by abrogation of rotenone-induced motor deficits, oxidative dysfunctions, and neurotoxicity in mice.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Antioxidants; Biomarkers; Cell Membrane; Drosophila melanogaster; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mitochondria; Motor Activity; Neurons; Neuroprotective Agents; Neurotoxins; Nitrosation; Oxidative Stress; Plant Extracts; Protein Carbonylation; Rotenone; Selaginellaceae; Tyrosine | 2013 |
Glutamatergic dysbalance and oxidative stress in in vivo and in vitro models of psychosis based on chronic NMDA receptor antagonism.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Hippocampus; Male; Oxidative Stress; Rats; Rats, Long-Evans; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tyrosine | 2013 |
Beneficial effects of (RS)-glucoraphanin on the tight junction dysfunction in a mouse model of restraint stress.
Topics: Animals; Blood-Brain Barrier; Caspase 3; Claudins; Coloring Agents; Cytokines; Enzyme Activation; Evans Blue; GA-Binding Protein Transcription Factor; Glial Fibrillary Acidic Protein; Glucosinolates; Glycoside Hydrolases; Imidoesters; Mice; Nitric Oxide Synthase Type II; Oximes; Restraint, Physical; Stress, Psychological; Sulfoxides; Tight Junctions; Transcription Factor RelA; Tyrosine | 2013 |
Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.
Topics: Aging; Animals; Blotting, Western; Brain; Cognition Disorders; Diet; Disease Models, Animal; Isoelectric Focusing; Male; Mass Spectrometry; Nitrosation; Proteomics; Rats; Rats, Inbred F344; Tyrosine; Vitamin D Deficiency | 2013 |
Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo.
Topics: Animals; Cardiotonic Agents; Cytoprotection; Heart; Ischemic Postconditioning; Male; Metalloporphyrins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2013 |
Increased phosphorylation of AKT in high-risk gastric mucosa.
Topics: Cell Line, Tumor; Gastric Mucosa; Humans; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Proto-Oncogene Proteins c-akt; Risk Factors; Stomach Neoplasms; Telomerase; Tyrosine | 2013 |
Antioxidant properties of glutamine and its role in VEGF-Akt pathways in portal hypertension gastropathy.
Topics: Animals; Antioxidants; Disease Models, Animal; Esophageal and Gastric Varices; Glutamine; Glutathione; Hypertension, Portal; Male; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Stomach; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Brain aging and testosterone-induced neuroprotection: studies on cultured sheep cortical neurons.
Topics: Aging; Animals; Cerebral Cortex; DNA Topoisomerases, Type II; DNA-Binding Proteins; Neurons; Neuroprotective Agents; Sheep; Testosterone; Tyrosine; Up-Regulation | 2013 |
Noise-induced nitrotyrosine increase and outer hair cell death in guinea pig cochlea.
Topics: Animals; Cell Death; Cochlea; Female; Guinea Pigs; Hair Cells, Auditory, Outer; Immunohistochemistry; Male; Noise; Organ of Corti; Tyrosine | 2013 |
L-Arginine supplementation improves antioxidant defenses through L-arginine/nitric oxide pathways in exercised rats.
Topics: Amino Acid Transport Systems, Basic; Animals; Antioxidants; Aorta, Abdominal; Arginine; Dietary Supplements; Lactic Acid; Male; Muscle Fatigue; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Physical Conditioning, Animal; Physical Exertion; Rats; Rats, Sprague-Dawley; Sedentary Behavior; Signal Transduction; Superoxide Dismutase; Swimming; Time Factors; Tyrosine | 2013 |
High dose remifentanil increases myocardial oxidative stress and compromises remifentanil infarct-sparing effects in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analgesics, Opioid; Animals; Deoxyguanosine; Dose-Response Relationship, Drug; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Malondialdehyde; Myocardial Infarction; Myocardium; Oxidative Stress; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Superoxide Dismutase; Superoxides; Tyrosine | 2013 |
Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas.
Topics: Albumins; Animals; Brain Neoplasms; Contrast Media; Cyclic N-Oxides; Disease Models, Animal; Free Radicals; Gadolinium DTPA; Glioma; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Nitrogen Oxides; Oxidation-Reduction; Radiography; Spin Labels; Spin Trapping; Tumor Cells, Cultured; Tyrosine | 2013 |
Levels of biological markers of nitric oxide in serum of patients with squamous cell carcinoma of the oral cavity.
Topics: Aged; Carcinoma, Squamous Cell; Case-Control Studies; Female; Humans; Lipid Peroxidation; Male; Malondialdehyde; Mouth Neoplasms; Nitric Oxide; Statistics, Nonparametric; Tyrosine | 2013 |
3-nitrotyrosine, a biomarker for cardiomyocyte apoptosis induced by diabetic cardiomyopathy in a rat model.
Topics: Animals; Apoptosis; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Tetrazoles; Tyrosine; Valine; Valsartan | 2013 |
In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping.
Topics: Aldehydes; Animals; Astrocytes; Brain; Cell Line; Cyclic N-Oxides; Free Radicals; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Oxidative Stress; Sepsis-Associated Encephalopathy; Spin Labels; Spin Trapping; Tyrosine | 2013 |
Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Survival; Humans; Hydrogen Peroxide; Mice; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Proteins; Tyrosine | 2013 |
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.
Topics: Aldehydes; Animals; Apoptosis; Autophagy; Berberine; Blood Urea Nitrogen; Cisplatin; Creatinine; Cytochrome P-450 CYP2E1; Kidney; Male; Mice; Mice, Inbred BALB C; Nephritis; Oxidative Stress; Protective Agents; Tyrosine | 2013 |
Role of oxidative and nitrosative stress in autogenous bone grafts to the mandible using guided bone regeneration and a deproteinized bovine bone material.
Topics: Animals; Autografts; Bone Matrix; Bone Remodeling; Bone Substitutes; Bone Transplantation; Cattle; Collagen; Dinoprost; Extracellular Signal-Regulated MAP Kinases; Female; Guided Tissue Regeneration; Mandible; Membranes, Artificial; Nitrosation; Osteoblasts; Osteoclasts; Osteocytes; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Nitrogen Species; Reactive Oxygen Species; Sheep; Tyrosine | 2014 |
Determination of nitration degrees for the birch pollen allergen Bet v 1.
Topics: Antigens, Plant; Betula; Calibration; Chromatography, High Pressure Liquid; Peroxynitrous Acid; Plant Proteins; Pollen; Protein Processing, Post-Translational; Recombinant Proteins; Tyrosine | 2013 |
Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats.
Topics: Animals; Biomarkers; Caspase 3; Creatine Kinase, BB Form; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dinoprost; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Severity of Illness Index; STAT3 Transcription Factor; Stroke Volume; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Ventricular Function, Left; Ventricular Pressure | 2013 |
Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2.
Topics: Amino Acid Sequence; Aminopeptidases; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Glycoproteins; Heme; Humans; Methionyl Aminopeptidases; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Tyrosine | 2013 |
Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells.
Topics: Antioxidants; Biopterins; Cell Line; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Humans; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Phosphorylation; Protein Multimerization; Pyruvaldehyde; Superoxides; Time Factors; Tyrosine | 2013 |
Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Angiography; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Epoprostenol; Fibrosis; Male; Microcirculation; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Tyrosine; Vasoconstriction; Vasodilation; Vasodilator Agents | 2013 |
Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese workers.
Topics: Adolescent; Adult; Aged; Arginase; Arginine; Cross-Sectional Studies; Exhalation; Female; Forced Expiratory Volume; Healthy Volunteers; Humans; Immunoglobulin E; Japan; Male; Middle Aged; Nitric Oxide; Tyrosine; Young Adult | 2014 |
Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.
Topics: Animals; Anti-Infective Agents, Local; Anticarcinogenic Agents; Autophagy; Blotting, Western; Cytochrome P-450 CYP2E1; Ethanol; Fatty Liver; Glutathione; Heme Oxygenase-1; Hep G2 Cells; Humans; Isothiocyanates; Lipid Peroxidation; Liver; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Sulfoxides; Tyrosine | 2014 |
[Simultaneous determination of tryptophan and its metabolites in plasma by high performance liquid chromatography with on-column derivatization].
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Pregnancy; Reproducibility of Results; Tryptophan; Tyrosine; Zinc Acetate | 2013 |
Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats.
Topics: Animals; Collagen; Female; Fibrosis; Fluorescent Antibody Technique; Heart Failure, Diastolic; Hemodynamics; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging; Microscopy, Electron, Transmission; Mitochondria, Heart; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Sodium, Dietary; Tyrosine; Ventricular Function, Left | 2013 |
Studies on peroxynitrite-modified H1 histone: implications in systemic lupus erythematosus.
Topics: Anilino Naphthalenesulfonates; Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoantibodies; Cross Reactions; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Histones; Humans; Immunization; Immunoglobulin G; Lupus Erythematosus, Systemic; Peroxynitrous Acid; Rabbits; Tyrosine | 2014 |
Association between erythrocyte n-3 polyunsaturated fatty acids and biomarkers of inflammation and oxidative stress in patients with and without depression.
Topics: Adult; Asian People; Biomarkers; Case-Control Studies; Depression; Erythrocytes; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Inflammation; Interferon-gamma; Male; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Nitric oxide synthase mediates PC12 differentiation induced by the surface topography of nanostructured TiO2.
Topics: Animals; Biocompatible Materials; Cell Differentiation; Cell Proliferation; Gene Expression Regulation; Humans; Mechanotransduction, Cellular; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Growth Factor; Neurites; Nitric Oxide; Nitric Oxide Synthase Type II; PC12 Cells; Rats; Surface Properties; Titanium; Tyrosine | 2013 |
Capacity of HSYA to inhibit nitrotyrosine formation induced by focal ischemic brain injury.
Topics: Animals; Brain Ischemia; Chalcone; Gene Expression; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Quinones; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
A light-activated NO donor attenuates anchorage independent growth of cancer cells: Important role of a cross talk between NO and other reactive oxygen species.
Topics: Breast Neoplasms; Catalase; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Humans; Hydrogen Peroxide; Light; Nitric Oxide; Organometallic Compounds; Phosphorylation; Proto-Oncogene Proteins c-akt; Superoxide Dismutase; Superoxides; Tyrosine | 2013 |
Effects of 47C allele (rs4880) of the SOD2 gene in the production of intracellular reactive species in peripheral blood mononuclear cells with and without lipopolysaccharides induction.
Topics: Adult; Cells, Cultured; DNA Damage; Genetic Association Studies; Humans; Kinetics; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Mitochondria; Nitrites; Oxidative Stress; Polymorphism, Single Nucleotide; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Young Adult | 2014 |
Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.
Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pain; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2014 |
Diverse effects of parenteral arginine on systemic and local oxidant-antioxidant homeostasis and nitrosative stress in rats with subacute peritonitis.
Topics: Animals; Antioxidants; Arginine; Disease Models, Animal; Energy Intake; Homeostasis; Infusions, Parenteral; Kidney; Lipid Peroxidation; Male; Nitric Oxide; Oxidants; Oxidative Stress; Peritonitis; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Severity of Illness Index; Tyrosine | 2014 |
Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing.
Topics: Angiogenesis Inducing Agents; Animals; Diabetes Mellitus, Experimental; Flavonoids; Glutathione; Hydrogen Peroxide; Inflammation; Interleukin-1beta; Liver; Male; Neovascularization, Pathologic; Oxidative Stress; Phenols; Propiophenones; Rats; Rats, Wistar; Skin; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing | 2013 |
Effects of Mn (II) on peroxynitrite nitrifying fibrinogen.
Topics: Animals; Blood Coagulation; Blood Coagulation Tests; Cattle; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Glycoproteins; Manganese; Nitrogen; Peroxynitrous Acid; Spectrometry, Fluorescence; Thrombin; Time Factors; Tyrosine | 2014 |
Nitrotyrosine level was associated with mortality in patients with acute kidney injury.
Topics: Acute Kidney Injury; Analysis of Variance; Case-Control Studies; Cohort Studies; Female; Humans; Male; Prospective Studies; Tyrosine | 2013 |
Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
Topics: Adult; Aged; Animals; Apoptosis; Carrier Proteins; Cells, Cultured; Ependymoglial Cells; Female; Glaucoma, Open-Angle; Humans; Inflammation; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; N-Methylaspartate; Neurotoxicity Syndromes; Retina; Thioredoxin-Disulfide Reductase; Thioredoxins; Tumor Necrosis Factor-alpha; Tyrosine; Vascular System Injuries | 2014 |
Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.
Topics: Amides; Animals; Catalase; Glutathione; Inflammation; Kidney; Male; Malondialdehyde; MAP Kinase Kinase 1; MAP Kinase Signaling System; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; rhoA GTP-Binding Protein; Superoxide Dismutase; Tyrosine | 2014 |
A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates.
Topics: Enzyme Inhibitors; HEK293 Cells; Humans; Kinetics; Protein Tyrosine Phosphatases; Spectrophotometry; Substrate Specificity; Tyrosine; Vanadates | 2014 |
Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults.
Topics: Aged; Antioxidants; Ascorbic Acid; Brachial Artery; Diet; Endothelial Cells; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; NADPH Oxidases; Niacin; Oxidative Stress; Regional Blood Flow; Tyrosine; Vasodilation; Vasodilator Agents; Vitamin B Complex | 2014 |
Dietary fish oil reduces systemic inflammation and ameliorates sepsis-induced liver injury by up-regulating the peroxisome proliferator-activated receptor gamma-mediated pathway in septic mice.
Topics: Animals; Biomarkers; Fatty Acids, Omega-3; Fish Oils; Inflammation; Interleukin-10; Interleukin-6; Liver; Liver Diseases; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; PPAR gamma; Sepsis; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2014 |
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
Topics: Animals; Caspase 3; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Lythraceae; Male; Mitochondrial Diseases; Nitric Oxide Synthase Type II; Oxidative Stress; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Substantia Nigra; Tyrosine | 2014 |
Oxidative stress-associated neuroretinal dysfunction and nitrosative stress in diabetic retinopathy.
Topics: Adult; Case-Control Studies; Diabetic Retinopathy; Female; Glutamic Acid; Humans; Leukocytes, Mononuclear; Male; Malondialdehyde; Middle Aged; Nitrites; Oxidative Stress; Reactive Oxygen Species; Retina; Tyrosine; Vitreous Body | 2013 |
Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption.
Topics: Animals; Blood-Brain Barrier; Cell Membrane; Claudin-5; Endothelial Cells; Guinea Pigs; Hypoxia; Microvessels; Mitochondria; Oxidative Stress; Permeability; Reactive Oxygen Species; Reperfusion Injury; Tight Junction Proteins; Tight Junctions; Tyrosine; Zonula Occludens-1 Protein | 2013 |
Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome.
Topics: Adult; Biomarkers; Birth Weight; Blood Proteins; Female; Fetal Blood; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Small for Gestational Age; Male; Malondialdehyde; Micronutrients; Oxidative Stress; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Protein Carbonylation; Tyrosine; Vitamin A; Vitamin A Deficiency | 2014 |
Vitamin E is essential for Purkinje neuron integrity.
Topics: alpha-Tocopherol; Animals; Carrier Proteins; Cerebellum; Mice; Mice, Knockout; Motor Activity; Oxidative Stress; Prefrontal Cortex; Purkinje Cells; Tyrosine; Vitamin E Deficiency | 2014 |
Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients.
Topics: Aged; Animals; Arterioles; beta-Cyclodextrins; Caveolae; Caveolin 1; Cells, Cultured; Diabetes Mellitus; Endothelial Cells; Endothelium, Vascular; Female; Humans; Male; Mice; Mice, Knockout; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Pterins; Regional Blood Flow; Tyrosine; Vasodilation | 2014 |
Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Coenzyme A; Epilepsy, Temporal Lobe; Glutathione; Glutathione Disulfide; Hippocampus; Kainic Acid; Male; Mitochondria; Neurons; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Seizures; Severity of Illness Index; Time Factors; Tyrosine | 2014 |
Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm.
Topics: Acetylcholine; Aged; Aldehydes; Biomarkers; Coronary Vasospasm; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Oxidative Stress; Tyrosine | 2014 |
Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-α: the role of PKC-β2 and NADPH oxidase.
Topics: Apoptosis; Cell Survival; Cytoprotection; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; L-Lactate Dehydrogenase; Malondialdehyde; NADPH Oxidases; Nitrates; Nitrites; Nitroglycerin; Phthalimides; Propofol; Protein Kinase C beta; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease.
Topics: Adolescent; Adult; alpha-Galactosidase; Animals; Biomarkers; Case-Control Studies; Cell Line; Disease Models, Animal; Endothelial Cells; Fabry Disease; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type III; RNA, Small Interfering; Tyrosine; Vascular Diseases; Young Adult | 2014 |
Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction.
Topics: Animals; Antioxidants; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Movement; Disease Models, Animal; Lac Operon; Male; Mice; Mice, Transgenic; Myocardial Infarction; Myocytes, Cardiac; Reactive Nitrogen Species; Reactive Oxygen Species; Stem Cell Transplantation; Stem Cells; Time Factors; Tyrosine; Ventricular Remodeling | 2014 |
Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry.
Topics: Animals; Baculoviridae; Cyclic GMP-Dependent Protein Kinase Type I; Gene Expression; Humans; Kinetics; Mutation; Nitrates; Nitric Oxide; Peptide Fragments; Peroxynitrous Acid; Phenylalanine; Recombinant Proteins; Sf9 Cells; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spodoptera; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2014 |
Identification of nitrated immunoglobulin variable regions in the HIV-infected human brain: implications in HIV infection and immune response.
Topics: Amino Acid Sequence; Antibodies; Brain; Brain Chemistry; Encephalitis, Viral; HIV Infections; HIV-1; Humans; Immunity, Innate; Immunoglobulin Variable Region; Models, Molecular; Molecular Sequence Data; Nitrates; Tyrosine | 2014 |
Decrease in 3-nitrotyrosine in the amniotic fluid of women with cytomegalovirus infection.
Topics: Amniotic Fluid; Case-Control Studies; Cytomegalovirus Infections; Female; Humans; Oxidative Stress; Pregnancy; Pregnancy Complications, Infectious; Tyrosine | 2014 |
Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation.
Topics: Aged; Albumins; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Female; Glycosylation; Humans; Male; Molsidomine; Neurons; Peptide Fragments; Protein Aggregates; Protein Processing, Post-Translational; tau Proteins; Trypsin; Tyrosine | 2014 |
Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Cell Death; Disease Models, Animal; Disease Progression; Lumbar Vertebrae; Male; Motor Activity; Motor Neurons; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Paralysis; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2014 |
In utero exposure to diesel exhaust air pollution promotes adverse intrauterine conditions, resulting in weight gain, altered blood pressure, and increased susceptibility to heart failure in adult mice.
Topics: Air Pollutants; Animals; Aorta; Blood Pressure; Echocardiography; Female; Heart Failure; Inflammation; Inhalation Exposure; Leukocyte Common Antigens; Male; Maternal Exposure; Mice; Mice, Inbred C57BL; Myocardium; Necrosis; Oxidative Stress; Particle Size; Pregnancy; Pregnancy, Animal; Time Factors; Tyrosine; Vehicle Emissions; Weight Gain | 2014 |
3-nitrotyrosine levels in dichlorvos-induced neurotoxicity.
Topics: Animals; Brain; Dichlorvos; Insecticides; Lethal Dose 50; Male; Neurotoxicity Syndromes; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Tyrosine | 2014 |
Oxidative and nitrosative stress induced in myofibrillar proteins by a hydroxyl-radical-generating system: impact of nitrite and ascorbate.
Topics: Ascorbic Acid; Dose-Response Relationship, Drug; Hydrogen Peroxide; Hydroxyl Radical; Myofibrils; Nitrites; Oxidation-Reduction; Oxidative Stress; Proteins; Schiff Bases; Tryptophan; Tyrosine | 2014 |
Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional.
Topics: Animals; Antibodies, Monoclonal; Aorta; Apolipoprotein A-I; Coronary Vessels; Escherichia coli; Humans; Male; Mice; Mice, Inbred BALB C; Peroxidases; Plaque, Atherosclerotic; Protein Processing, Post-Translational; Reactive Nitrogen Species; Recombinant Proteins; Tyrosine; Ultracentrifugation | 2014 |
Nitrosative stress does not change during orthotopic liver transplantation.
Topics: Biomarkers; Case-Control Studies; End Stage Liver Disease; Humans; Liver Transplantation; Nitroso Compounds; Oxidative Stress; Reactive Nitrogen Species; Reperfusion Injury; Risk Factors; Serum Albumin; Serum Albumin, Human; Time Factors; Treatment Outcome; Tyrosine | 2014 |
Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Lactones; Male; Mice; NF-kappa B; Pleurisy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sesquiterpenes; STAT3 Transcription Factor; Tyrosine | 2014 |
Effect of oxidative stress on the expression of thin filament-associated proteins in gastric smooth muscle cells.
Topics: Animals; Gastrointestinal Motility; Gene Expression Regulation; Male; Microfilament Proteins; Molsidomine; Muscle, Smooth; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stomach; Tyrosine | 2014 |
Caffeic acid phenethyl ester (CAPE): scavenger of peroxynitrite in vitro and in sepsis models.
Topics: Animals; Caffeic Acids; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Free Radical Scavengers; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice, Inbred BALB C; Nitric Oxide; Peroxynitrous Acid; Phenylethyl Alcohol; Sepsis; Tyrosine | 2014 |
Hyperbaric oxygen preconditioning protects rats against CNS oxygen toxicity.
Topics: Animals; Blotting, Western; Catalase; Central Nervous System Diseases; Frontal Lobe; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hippocampus; Hyperbaric Oxygenation; Male; Oxygen; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2014 |
Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes.
Topics: Benzo(a)pyrene; Biomarkers; Carcinogens; Caspase 3; Cell Line; Cells, Cultured; Dinoprost; Free Radicals; Heterocyclic Compounds, 3-Ring; Humans; Keratinocytes; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Tyrosine | 2014 |
Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Antioxidants; Biomarkers, Tumor; Deoxyguanosine; Female; Hodgkin Disease; Humans; Immunohistochemistry; Male; Microscopy, Immunoelectron; Mitochondria; Oxidative Stress; Peroxiredoxins; Prognosis; Reed-Sternberg Cells; Superoxide Dismutase; Tyrosine | 2014 |
S-nitrosoglutathione inhibits inducible nitric oxide synthase upregulation by redox posttranslational modification in experimental diabetic retinopathy.
Topics: Analysis of Variance; Animals; Biomarkers; Cell Line; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Electroretinography; Glial Fibrillary Acidic Protein; Glutathione; Humans; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Ophthalmic Solutions; Rats; Reactive Oxygen Species; Retina; S-Nitrosoglutathione; Tyrosine; Up-Regulation | 2014 |
Subclinical mastitis in goats is associated with upregulation of nitric oxide-derived oxidative stress that causes reduction of milk antioxidative properties and impairment of its quality.
Topics: Animals; Antioxidants; Bacterial Infections; Female; Food Contamination; Food Microbiology; Goats; Lactation; Lactose; Mammary Glands, Animal; Mastitis; Milk; Nitric Oxide; Oxidative Stress; Peroxides; Protein Carbonylation; Staphylococcus; Tyrosine | 2014 |
Homoarginine and 3-nitrotyrosine in patients with takotsubo cardiomyopathy.
Topics: Aged; Aged, 80 and over; Biomarkers; Female; Homoarginine; Humans; Male; Middle Aged; Takotsubo Cardiomyopathy; Tyrosine | 2014 |
Supplemental L-arginine and vitamins E and C preserve xanthine oxidase activity in the lung of broiler chickens grown under hypobaric hypoxia.
Topics: Animal Feed; Animals; Arginine; Ascorbic Acid; Avian Proteins; Biomarkers; Chickens; Diet; Dietary Supplements; Histocytochemistry; Hydrogen Peroxide; Lung; Microscopy, Confocal; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Oxygen; Tyrosine; Vitamin E; Xanthine Oxidase | 2014 |
s-Methyl cysteine enhanced survival of nerve growth factor differentiated PC12 cells under hypoxic conditions.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Caspase 8; Cell Differentiation; Cell Survival; Cysteine; DNA Fragmentation; Dose-Response Relationship, Drug; Glutathione Peroxidase; Glutathione Reductase; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Indazoles; Membrane Potential, Mitochondrial; Nerve Growth Factor; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pyridines; Pyrrolidines; Rats; Reactive Oxygen Species; Thiocarbamates; Tyrosine; Up-Regulation | 2014 |
Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension.
Topics: Adiponectin; Aldosterone; Animals; Antioxidants; Arginine; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomyopathies; Cardiotonic Agents; Chemokine CCL2; Chemokine CCL3; Cyclic GMP; Dinoprost; Endothelin-1; Enzyme Induction; Extracellular Matrix Proteins; Heart Failure; Heme; Heme Oxygenase (Decyclizing); Hypertension; Interleukin-1beta; Interleukin-6; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Engine exhaust particulate and gas phase contributions to vascular toxicity.
Topics: Acetylcholine; Animals; Bronchoalveolar Lavage Fluid; L-Lactate Dehydrogenase; Male; Mice; Particulate Matter; Tyrosine; Vasodilation; Vehicle Emissions | 2014 |
Evaluation of a method for nitrotyrosine site identification and relative quantitation using a stable isotope-labeled nitrated spike-in standard and high resolution fourier transform MS and MS/MS analysis.
Topics: Angiotensin I; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; Fourier Analysis; Isotope Labeling; Mass Spectrometry; Nitrogen Isotopes; Peroxynitrous Acid; Rats; Serum Albumin, Bovine; Tandem Mass Spectrometry; Tyrosine | 2014 |
Tim-3 cell signaling and iNOS are involved in the protective effects of ischemic postconditioning against focal ischemia in rats.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Ischemic Postconditioning; Male; Minocycline; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Signal Transduction; Tyrosine | 2015 |
Changes in oxidative stress parameters and antioxidant status in lung cancer: Western blot analysis of nitrotyrosine and protein carbonyls content.
Topics: Advanced Oxidation Protein Products; Aged; Aged, 80 and over; Antioxidants; Blotting, Western; Carcinoma; Case-Control Studies; Female; Humans; Lung Neoplasms; Male; Middle Aged; Protein Carbonylation; Tyrosine | 2014 |
Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.
Topics: Adolescent; Animals; Brain; Child; Child Development Disorders, Pervasive; Child, Preschool; Female; Gene Expression; Homeostasis; Humans; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Male; Mercury; Rats, Sprague-Dawley; Thyroid Hormones; Triiodothyronine, Reverse; Tyrosine | 2014 |
Effect of MPO/H2O2/NO(-) system on nitric oxide-mediated modification of TTR amyloid and serum TTR in FAP ATTR Val30Met patients.
Topics: Adult; Amyloid; Amyloid Neuropathies, Familial; Female; Humans; Hydrogen Peroxide; Lipoproteins, HDL; Middle Aged; Mutation; Nitric Oxide; Peroxidase; Prealbumin; Tyrosine | 2014 |
Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats.
Topics: Animals; Antioxidants; Breast Diseases; Dietary Supplements; Estrogens; Female; Humans; Hyperplasia; Mammary Glands, Animal; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Inbred ACI; RNA, Messenger; Tocopherols; Tyrosine; Up-Regulation | 2015 |
Alleviation of plasma homocysteine level by phytoestrogen α-zearalanol might be related to the reduction of cystathionine β-synthase nitration.
Topics: Animals; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Female; Homocysteine; Hyperhomocysteinemia; Liver; Nitrates; Oxidation-Reduction; Phytoestrogens; Rats; Rats, Wistar; Treatment Outcome; Tyrosine; Zeranol | 2014 |
Aging aggravates nitrate-mediated ROS/RNS changes.
Topics: Adult; Aged; Aging; Angina, Unstable; Animals; Aorta, Thoracic; Female; Glutathione; Humans; Isosorbide Dinitrate; Male; Malondialdehyde; Middle Aged; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2014 |
Nitrosative stress triggers microtubule reorganization in Arabidopsis thaliana.
Topics: Arabidopsis; Dinitrobenzenes; Microtubules; Mitosis; Nitric Oxide; Paclitaxel; Plant Roots; Stress, Physiological; Sulfanilamides; Tyrosine | 2014 |
Blood-brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Claudin-5; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Up-Regulation; Zonula Occludens-1 Protein | 2014 |
Neuroprotective effects of tibolone against oxidative stress induced by ozone exposure.
Topics: Aldehydes; Animals; Atmosphere Exposure Chambers; Behavior, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Hippocampus; Learning; Lipid Peroxidation; Male; Nerve Tissue Proteins; Neuroprotective Agents; Norpregnenes; Oxidative Stress; Ozone; Pyramidal Cells; Random Allocation; Rats; Rats, Wistar; Tyrosine | 2014 |
Perivascular iron deposits are associated with protein nitration in cerebral experimental autoimmune encephalomyelitis.
Topics: Albumins; Animals; Blood-Brain Barrier; Cerebral Cortex; Encephalomyelitis, Autoimmune, Experimental; Female; Iron; Mice; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proteins; Tyrosine | 2014 |
Tyrosine nitration in peptides by peroxynitrite generated in situ in a light-controlled platform: effects of pH and thiols.
Topics: Carbon Dioxide; Glutathione; Hydrogen-Ion Concentration; Light; Peroxynitrous Acid; Sulfhydryl Compounds; Tyrosine | 2014 |
Gap junction proteins in the light-damaged albino rat.
Topics: Animals; Blotting, Western; Cell Death; Connexin 43; Connexins; Eye; Female; Gap Junction delta-2 Protein; In Situ Nick-End Labeling; Light; Macrophages; Male; Photoreceptor Cells, Vertebrate; Rats; Rats, Sprague-Dawley; Retinal Pigment Epithelium; Tyrosine | 2014 |
Nitrosative stress and nitrated proteins in trichloroethene-mediated autoimmunity.
Topics: Animals; Autoantibodies; Autoimmunity; Female; Glutathione; Liver; Mice; Mice, Mutant Strains; NF-kappa B; Nitric Oxide Synthase Type II; Trichloroethylene; Tyrosine | 2014 |
Role of oxidative stress-induced systemic and cavernosal molecular alterations in the progression of diabetic erectile dysfunction.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Progression; Endothelium, Vascular; Erectile Dysfunction; Fluorescent Antibody Technique; Immunoblotting; Male; Myocytes, Smooth Muscle; Nitric Oxide Synthase Type III; Oxidative Stress; Penis; Rats; Rats, Wistar; Tyrosine | 2015 |
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Survival; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glutamate Plasma Membrane Transport Proteins; Humans; Male; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Tyrosine | 2014 |
Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Eye Proteins; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Intraperitoneal; Male; Malondialdehyde; Melatonin; Nerve Growth Factors; Oxidative Stress; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Wistar; Retinal Vessels; Serpins; Tyrosine; Vascular Endothelial Growth Factor A | 2014 |
A comparison of factors involved in the development of central nervous system and pulmonary oxygen toxicity in the rat.
Topics: Animals; Catalase; Cerebral Cortex; Glutathione Peroxidase; Hippocampus; Hyperoxia; Lung; Male; Nitric Oxide Synthase Type I; Pressure; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase; Tyrosine | 2014 |
Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.
Topics: Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Ectodysplasins; Ethidium; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Guanine; Microscopy, Electron, Transmission; Mitochondria; Myelin Basic Protein; Nerve Degeneration; Optic Nerve Injuries; Oxidative Stress; Rats; Reactive Oxygen Species; Tandem Mass Spectrometry; Time Factors; Tyrosine | 2014 |
β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Antioxidants; Benzopyrans; Blood Pressure; Down-Regulation; Ethanolamines; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Kidney; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Metoprolol; Nebivolol; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine; Ventricular Remodeling | 2014 |
Effects of topically applied tocotrienol on cataractogenesis and lens redox status in galactosemic rats.
Topics: Administration, Topical; Animals; Anterior Eye Segment; Catalase; Cataract; Disease Progression; Emulsions; Eye Proteins; Galactosemias; Glutathione; Lens, Crystalline; Liposomes; Malondialdehyde; Nitric Oxide Synthase Type II; Oxidation-Reduction; Particle Size; Rats; Rats, Sprague-Dawley; Static Electricity; Stress, Physiological; Superoxide Dismutase; Tocotrienols; Tyrosine; Viscosity | 2014 |
"Back to the future" or iron in the MS brain - commentary on "perivascular iron deposits are associated with protein nitration in cerebral experimental autoimmune encephalomyelitis".
Topics: Animals; Cerebral Cortex; Encephalomyelitis, Autoimmune, Experimental; Female; Iron; Proteins; Tyrosine | 2014 |
Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brachial Artery; Endothelium; Exercise; Female; Habits; Humans; Male; Middle Aged; NF-kappa B; Regional Blood Flow; Salicylates; Sedentary Behavior; Signal Transduction; Tyrosine; Vasodilation | 2014 |
Enhanced vasoconstriction to α1 adrenoceptor autoantibody in spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Aorta; Autoantibodies; Blotting, Western; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tyrosine; Vasoconstriction; Vasoconstrictor Agents | 2014 |
Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Ammonia; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; DNA Fragmentation; DNA-Binding Proteins; Glutathione; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Transgenic; Phenylbutyrates; Protective Agents; Proto-Oncogene Proteins; Regulatory Factor X Transcription Factors; Transcription Factor CHOP; Transcription Factors; Tyrosine; X-Box Binding Protein 1 | 2014 |
Comparison of nasal nitric oxide levels between the inferior turbinate surface and the middle meatus in patients with symptomatic allergic rhinitis.
Topics: Adult; Biomarkers; Breath Tests; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Exhalation; Female; Humans; Male; Nasal Cavity; Nitric Oxide; Rhinitis, Allergic; Turbinates; Tyrosine | 2014 |
Early endothelial nitrosylation and increased abdominal adiposity in Wistar rats after long-term consumption of food fried in canola oil.
Topics: Acetylcholine; Adiposity; Animals; Aorta; Brassica rapa; Cooking; Diet; Dietary Fats, Unsaturated; Endothelium, Vascular; Fatty Acids, Monounsaturated; Intra-Abdominal Fat; Male; Obesity, Abdominal; Plant Oils; Rapeseed Oil; Rats, Wistar; Time Factors; Tyrosine; Vascular Diseases; Vasodilation | 2014 |
Oxidative stress in older patients with bipolar disorder.
Topics: Aged; Aldehydes; Bipolar Disorder; Case-Control Studies; Female; Humans; Lipid Peroxides; Male; Middle Aged; Oxidative Stress; Protein Carbonylation; Tyrosine | 2015 |
3-Nitrotyrosine as a biomarker for vascular involvement in Fabry disease.
Topics: Animals; Fabry Disease; Humans; Male; Tyrosine; Vascular Diseases | 2014 |
Self-recognition behavior of a helix-loop-helix domain by a fragment scan.
Topics: Amino Acid Sequence; Circular Dichroism; Helix-Loop-Helix Motifs; High-Throughput Screening Assays; Humans; Inhibitor of Differentiation Protein 1; Kinetics; Ligands; Molecular Sequence Data; Oligopeptides; ortho-Aminobenzoates; Protein Binding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Staining and Labeling; Tyrosine | 2014 |
Adipose and leptomeningeal arteriole endothelial dysfunction induced by β-amyloid peptide: a practical human model to study Alzheimer's disease vasculopathy.
Topics: Abdomen; Acetylcholine; Adipose Tissue; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Arterioles; Endothelial Cells; Female; Humans; Male; Meninges; Middle Aged; Oxidative Stress; Papaverine; Peptide Fragments; Reactive Oxygen Species; Tyrosine; Vasodilator Agents | 2014 |
Effect of obtusifolin administration on retinal capillary cell death and the development of retinopathy in diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Anthraquinones; Antioxidants; Apoptosis; Capillaries; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Hyperglycemia; Male; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Retina; Tyrosine | 2014 |
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.
Topics: Adipose Tissue; Aging; Animals; Arteries; Body Weight; Carnitine; Glutamic Acid; Malates; Male; Mice; Mitochondria; Neovascularization, Physiologic; Oxidative Stress; Oxygen Consumption; Succinic Acid; Triglycerides; Tyrosine; Vasodilation | 2014 |
Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Brain; Brain Ischemia; Cell Death; Endoplasmic Reticulum Stress; Immunohistochemistry; Indicators and Reagents; Ischemic Attack, Transient; Lignans; Male; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Stroke; Transcription Factor CHOP; Tyrosine | 2014 |
Nitrosative Stress and Apoptosis by Intravenous Ferumoxytol, Iron Isomaltoside 1000, Iron Dextran, Iron Sucrose, and Ferric Carboxymaltose in a Nonclinical Model.
Topics: Administration, Intravenous; Animals; Apoptosis; Caspase 3; Disaccharides; Female; Ferric Compounds; Ferric Oxide, Saccharated; Ferrosoferric Oxide; Glucaric Acid; Iron-Dextran Complex; Kidney; Liver; Male; Maltose; Models, Animal; Myocardium; Rats; Tyrosine | 2015 |
Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice.
Topics: alpha-Tocopherol; Animals; Caspase 3; Cell Line; Cell Survival; Dietary Supplements; Disease Models, Animal; DNA-Binding Proteins; Lysosomes; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurodegenerative Diseases; Niemann-Pick Disease, Type C; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-abl; Signal Transduction; Tumor Protein p73; Tumor Suppressor Proteins; Tyrosine; Vitamin E | 2014 |
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model.
Topics: 8-Hydroxy-2'-Deoxyguanosine; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Resorption; Cytokines; Deoxyguanosine; Disease Models, Animal; Gingiva; Inflammation; Male; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; Periodontitis; Random Allocation; Rats; Rats, Wistar; Resveratrol; Sirtuin 1; Stilbenes; Tyrosine | 2014 |
Detection of in vivo protein tyrosine nitration in petite mutant of Saccharomyces cerevisiae: consequence of its formation and significance.
Topics: Peroxynitrous Acid; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine | 2014 |
Oxidative stress and antioxidant status in patients with autoimmune liver diseases.
Topics: Adult; Aged; Aldehydes; Antioxidants; Autoimmune Diseases; Carbon; Catalase; Disease Progression; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hepatitis, Autoimmune; Humans; Isoprostanes; Liver Diseases; Male; Middle Aged; Oxidative Stress; Peroxidase; Superoxide Dismutase; Tyrosine | 2015 |
Kinetics of 3-nitrotyrosine modification on exposure to hypochlorous acid.
Topics: Biomarkers; Chloramines; Chromatography, High Pressure Liquid; Humans; Hypochlorous Acid; Kinetics; Peptide Fragments; Peroxidase; Reactive Nitrogen Species; Tyrosine | 2014 |
iNitro-Tyr: prediction of nitrotyrosine sites in proteins with general pseudo amino acid composition.
Topics: Amino Acid Sequence; Amino Acids; Internet; Molecular Sequence Data; Proteins; Tyrosine | 2014 |
May the thyroid gland and thyroperoxidase participate in nitrosylation of serum proteins and sporadic Parkinson's disease?
Topics: Aged; Case-Control Studies; Female; Humans; Iodide Peroxidase; Male; Middle Aged; Parkinson Disease; Protein Processing, Post-Translational; Thyroid Gland; Tyrosine | 2014 |
Propargylglycine aggravates liver damage in LPS-treated rats: Possible relation of nitrosative stress with the inhibition of H2S formation.
Topics: Alkynes; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Cystathionine gamma-Lyase; Endotoxemia; Glutathione; Glycine; Hydrogen Sulfide; Lipopolysaccharides; Liver Diseases; Male; Peroxidase; Rats; Rats, Wistar; Stress, Physiological; Tyrosine | 2014 |
Ultrasensitive internally quenched substrates of human cathepsin L.
Topics: Biological Assay; Cathepsin L; Cathepsins; Cell Line; Cell Line, Tumor; Humans; Hydrogen-Ion Concentration; Limit of Detection; ortho-Aminobenzoates; Peptides; Substrate Specificity; Tyrosine | 2014 |
N-acetylcysteine administration confers lung protection in different phases of lung ischaemia-reperfusion injury.
Topics: Acetylcysteine; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Cytoprotection; Disease Models, Animal; Hemodynamics; I-kappa B Kinase; Inflammation Mediators; Interleukin-1beta; Lipid Peroxidation; Lung; Lung Injury; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Activating Transcription Factor 4; Animals; Apoptosis; Chronic Disease; Copper Sulfate; Cyclic AMP Response Element-Binding Protein; Deoxyguanosine; Disks Large Homolog 4 Protein; DNA-Binding Proteins; eIF-2 Kinase; Guanylate Kinases; Hippocampus; Male; Membrane Proteins; Memory Disorders; Mice, Inbred C57BL; Neurons; Oxidative Stress; Random Allocation; Signal Transduction; Spatial Memory; Synapsins; Transcription Factor CHOP; Transcription Factors; Tyrosine | 2015 |
Histopathological findings, phenotyping of inflammatory cells, and expression of markers of nitritative injury in joint tissue samples from calves after vaccination and intraarticular challenge with Mycoplasma bovis strain 1067.
Topics: Animals; Antibodies, Bacterial; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Biomarkers; Cattle; Cattle Diseases; Cytokines; Histocompatibility Antigens Class II; Immunohistochemistry; Joints; Mycoplasma bovis; Mycoplasma Infections; Nitric Oxide Synthase Type II; Synovial Membrane; Tyrosine; Vaccination | 2014 |
Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine.
Topics: Animals; Basidiomycota; Brain Ischemia; CCAAT-Enhancer-Binding Proteins; Cell Death; Cytokines; Diterpenes; Male; Mycelium; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Transcription Factor CHOP; Tyrosine | 2014 |
The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Blood Platelets; Cyclic GMP; Drug Tolerance; Endothelium, Vascular; Humans; Hypotension; Isosorbide Dinitrate; Male; Metalloporphyrins; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Thrombin; Tyrosine; Vasodilator Agents | 2014 |
Deletion of metallothionein exacerbates intermittent hypoxia-induced oxidative and inflammatory injury in aorta.
Topics: Aldehydes; Animals; Aorta; Apoptosis; Connective Tissue Growth Factor; Hypoxia; Metallothionein; Mice; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
Topics: Animals; Cytokines; Female; Granuloma; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium bovis; Mycobacterium Infections; NADPH Oxidases; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Tyrosine | 2014 |
Atorvastatin ameliorates arsenic-induced hypertension and enhancement of vascular redox signaling in rats.
Topics: Animals; Aorta, Thoracic; Arsenites; Atorvastatin; Catalase; Cholesterol; Glutathione Peroxidase; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrroles; Random Allocation; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sodium Compounds; Superoxide Dismutase; Tyrosine | 2014 |
Mitochondrial DNA acquires immunogenicity on exposure to nitrosative stress in patients with vitiligo.
Topics: Adolescent; Adult; Autoantibodies; Autoimmune Diseases; Autoimmunity; Child; DNA, Mitochondrial; Female; Humans; Immunoglobulin G; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Peroxynitrous Acid; Tyrosine; Vitiligo; Young Adult | 2014 |
Mechanisms and kinetic profiles of superoxide-stimulated nitrosative processes in cells using a diaminofluorescein probe.
Topics: Animals; Biosensing Techniques; Cell Line; Fluorescein; Fluorescent Dyes; Kinetics; Mice; Nitric Oxide; Nitrosation; Oxygen Consumption; Superoxides; Tyrosine | 2014 |
Effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits.
Topics: Animals; Choroid; Diet; Flax; Hypercholesterolemia; Immunohistochemistry; Lipid Peroxidation; Lipids; Lipoproteins, LDL; Male; Rabbits; Retina; Sclera; Tyrosine | 2014 |
Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction.
Topics: Cell Line, Tumor; Cell Survival; Electron Transport Complex I; Glutathione; Humans; Immunohistochemistry; Lithium Compounds; Neuroblastoma; Protein Carbonylation; Rotenone; Tyrosine; Uncoupling Agents | 2015 |
MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Cell Line; Disease Models, Animal; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Mice, Inbred C57BL; MicroRNAs; Nitric Oxide; Oxidative Stress; Reperfusion Injury; Superoxide Dismutase; Transfection; Tyrosine; Up-Regulation | 2014 |
Rapamycin inhibits oxidative and angiogenic mediators in diabetic retinopathy.
Topics: Angiogenesis Modulating Agents; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Eye Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Malondialdehyde; Nerve Growth Factors; Oxidative Stress; Rats; Rats, Wistar; Serpins; Sirolimus; Tyrosine; Vascular Endothelial Growth Factor A | 2014 |
Hepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with Benznidazole.
Topics: Animals; Cell Death; Cell Line, Tumor; Chagas Disease; Chemical and Drug Induced Liver Injury; DNA Damage; Female; Hep G2 Cells; Humans; Liver; Male; Mice; Mitochondria; Nifurtimox; Nitrofurazone; Nitroimidazoles; Parasites; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Hemin improves insulin sensitivity in skeletal muscle in high fat-fed mice.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Body Weight; Cytokines; Depression, Chemical; Diet, High-Fat; Gene Expression; Glucose; Glucose Clamp Technique; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase (Decyclizing); Hemin; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Superoxide Dismutase; Triglycerides; Tyrosine | 2014 |
Identification and relative quantification of tyrosine nitration in a model peptide using two-dimensional infrared spectroscopy.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Mass Spectrometry; Peptides; Quantum Theory; Spectrophotometry, Infrared; Tyrosine | 2014 |
Biomarker differences between cadaveric grafts used in human orthotopic liver transplantation as identified by coulometric electrochemical array detection (CEAD) metabolomics.
Topics: Biomarkers; Homovanillic Acid; Humans; Kynurenine; Liver Transplantation; Metabolomics; Methionine; Tyrosine; Uric Acid; Xanthine | 2014 |
Expression and significance of plasma 3-NT and ox-LDL in patients with Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Gene Expression; Humans; Lipoproteins, LDL; Male; Middle Aged; Neuropsychological Tests; Severity of Illness Index; Tyrosine | 2014 |
Characterization of diabetic neuropathy in the Zucker diabetic Sprague-Dawley rat: a new animal model for type 2 diabetes.
Topics: Age Factors; Animals; Arterioles; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Neuropathies; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Langerhans Cells; Male; Neural Conduction; Nociception; Rats, Sprague-Dawley; Rats, Zucker; Sciatic Nerve; Time Factors; Triglycerides; Tyrosine; Vasodilation | 2014 |
Circulating levels of apelin, glucagon-like peptide and visfatin in hypercholesterolemic-hyperhomocysteinemic guinea-pigs: their relation with NO metabolism.
Topics: Animals; Arginine; Cholesterol; Glucagon-Like Peptides; Guinea Pigs; Humans; Hyperhomocysteinemia; Intercellular Signaling Peptides and Proteins; Male; Nicotinamide Phosphoribosyltransferase; Nitric Oxide; Tyrosine | 2015 |
Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation.
Topics: Azides; Azo Compounds; Peptides; Protein Processing, Post-Translational; Proteins; Tyrosine | 2015 |
Functionally deficient mesenchymal stem cells reside in the bone marrow niche with M2-macrophages and amyloid-β protein adjacent to loose total joint implants.
Topics: Aged; Amyloid beta-Protein Precursor; Arthroplasty, Replacement; Bone Marrow; Femur; Humans; Macrophages; Mesenchymal Stem Cells; Middle Aged; Osteogenesis; Prosthesis Failure; Reoperation; tau Proteins; Tyrosine | 2015 |
Evidence of Oxidative Injury in Pigs With Melanosis Coli.
Topics: Aldehydes; Animals; Colon; Colonic Diseases; Female; Macrophages; Malondialdehyde; Melanosis; Oxidative Stress; Swine; Tyrosine | 2015 |
[Effect of NO-synthesis blockade on the free-radical processes in rats of different genetic strains with acute alloxan diabetes].
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Lipid Peroxidation; Liver; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Strains; Rats, Wistar; Species Specificity; Tyrosine | 2013 |
Inhibition of ocular aldose reductase by a new benzofuroxane derivative ameliorates rat endotoxic uveitis.
Topics: Aldehyde Reductase; Animals; Antioxidants; Apoptosis; Benzofurans; Disease Models, Animal; Enzyme Inhibitors; Eye; Inflammation Mediators; Lipopolysaccharides; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tyrosine; Ubiquitin; Uveitis | 2014 |
Features of endothelial dysfunction in umbilical cord vessels of women with gestational diabetes.
Topics: Adult; Atherosclerosis; Blood Glucose; Cell Adhesion; Cyclic AMP; Diabetes, Gestational; Female; Glucose Tolerance Test; Homeostasis; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Leukocytes; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pregnancy; Tyrosine; Umbilical Cord; Vascular Diseases | 2014 |
A comparative study on renal biopsy before and after long-term calcineurin inhibitors therapy: an insight for pathogenesis of its toxicity.
Topics: Adolescent; Atrophy; Biomarkers; Biopsy; Calcineurin Inhibitors; Child; Child, Preschool; Early Diagnosis; Endothelial Cells; Female; Fibrosis; Humans; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Infant; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mitochondria; Nephrotic Syndrome; Nitric Oxide Synthase Type III; Oxidative Stress; Predictive Value of Tests; Time Factors; Transforming Growth Factor beta1; Treatment Outcome; Tyrosine; Up-Regulation | 2015 |
Interplay between pro-inflammatory cytokines and brain oxidative stress biomarkers: evidence of parallels between butyl paraben intoxication and the valproic acid brain physiopathology in autism rat model.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Autistic Disorder; Biomarkers; Brain; Brain Diseases; Chromatography, High Pressure Liquid; Female; Glutathione; Glutathione Disulfide; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Mitochondria; Oxidative Stress; Parabens; Pregnancy; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine; Valproic Acid | 2015 |
Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide.
Topics: Aging; Animals; Blotting, Western; Cells, Cultured; Cytosol; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitochondria; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide; Peroxiredoxins; Peroxynitrous Acid; Superoxides; Tyrosine | 2015 |
[Catecholamine content in the adrenal gland of rat offspring in the model of prenatal hyperhomocysteinemia].
Topics: Administration, Oral; Adrenal Glands; Animals; Animals, Newborn; Catecholamines; Disease Models, Animal; Female; Hyperhomocysteinemia; Methionine; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Tyrosine | 2014 |
The natural olive constituent oleuropein induces nutritional cardioprotection in normal and cholesterol-fed rabbits: comparison with preconditioning.
Topics: Animals; Cholesterol; Disease Models, Animal; Hypercholesterolemia; Iridoid Glucosides; Iridoids; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Olea; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protective Agents; Rabbits; Signal Transduction; Tyrosine | 2015 |
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
Topics: Activin Receptors, Type I; Aging; Animals; Cartilage, Articular; Collagen Type II; Computer Simulation; Extracellular Matrix; Immunohistochemistry; Interleukin-1; Knee Joint; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta; Tyrosine | 2016 |
Developing electrochemical sensor for point-of-care diagnostics of oxidative stress marker using imprinted bimetallic Fe/Pd nanoparticle.
Topics: Acrylamide; Acrylamides; Biomarkers; Calibration; Electrochemical Techniques; Humans; Iron; Limit of Detection; Metal Nanoparticles; Microscopy, Electron, Scanning; Oxidative Stress; Palladium; Point-of-Care Systems; Tyrosine | 2015 |
The impact of calcium ion on structure and aggregation propensity of peroxynitrite-modified lens crystallins: new insights into the pathogenesis of cataract disorders.
Topics: Animals; Benzothiazoles; Calcium; Cattle; Crystallins; Hydrophobic and Hydrophilic Interactions; Lens, Crystalline; Oxidants; Peroxynitrous Acid; Protein Aggregates; Protein Carbonylation; Protein Stability; Proteolysis; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Tyrosine | 2015 |
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Topics: Aging; Animals; Arginase; Cell Hypoxia; Enzyme Activation; Hypertension; Lung; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Pulmonary Artery; Rats, Sprague-Dawley; Tyrosine | 2015 |
Trans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice.
Topics: Aldehydes; Analysis of Variance; Animals; Brain; Brain Ischemia; Carotenoids; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Matrix Metalloproteinases; Mice; Nervous System Diseases; Neuroprotective Agents; Obesity; Oxidative Stress; Reperfusion; Tyrosine; Vitamin A | 2015 |
The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Benzenesulfonates; Beverages; Citrus; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; Mice; Neutrophil Infiltration; NF-kappa B; P-Selectin; Peroxidase; Plant Extracts; Poly Adenosine Diphosphate Ribose; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2015 |
Oxidative/Nitrosative Stress in Patients With Modic Changes: Preliminary Controlled Study.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Female; Humans; Low Back Pain; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Tyrosine | 2015 |
Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Brain; Brain Ischemia; Caspase 3; Cell Line, Tumor; Enzyme Activation; Female; Fibrinogen; Fibrinolysis; Humans; Male; Middle Aged; Neurons; Rats; Rats, Sprague-Dawley; Stroke; Tyrosine | 2015 |
Docosahexaenoic acid supplementation promotes erythrocyte antioxidant defense and reduces protein nitrosative damage in male athletes.
Topics: Adolescent; Adult; Antioxidants; Athletes; Dietary Supplements; Docosahexaenoic Acids; Erythrocytes; Exercise; Humans; Male; Malondialdehyde; Oxidative Stress; Superoxide Dismutase; Tyrosine; Young Adult | 2015 |
Inhibition of i-NOS but not n-NOS protects rat primary cell cultures against MPP(+)-induced neuronal toxicity.
Topics: Amidines; Animals; Antibodies, Monoclonal; Astrocytes; Benzylamines; Cell Count; Cells, Cultured; Dopaminergic Neurons; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Mesencephalon; Microglia; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Parkinson Disease; Picolines; Primary Cell Culture; Rats, Wistar; Thiophenes; Tyrosine; Tyrosine 3-Monooxygenase | 2015 |
Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma.
Topics: Animals; Apoptosis; Cell Respiration; Chemokines; Cytokines; Disease Models, Animal; Lung; Male; Mice, Inbred C57BL; Mitochondria, Muscle; Pulmonary Gas Exchange; Receptors, Purinergic; Respiratory Mechanics; Thoracic Injuries; Tyrosine; Wounds, Nonpenetrating | 2015 |
In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis.
Topics: Adenosine Triphosphate; DNA, Mitochondrial; Fatty Acids; Gene Expression Regulation, Neoplastic; Gene Silencing; Hep G2 Cells; Humans; Mitochondria; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Oxidative Phosphorylation; Oxidative Stress; Palmitic Acid; Protein Subunits; Thiobarbituric Acid Reactive Substances; Tyrosine | 2015 |
Effects of carnosine, taurine, and betaine pretreatments on diethylnitrosamine-induced oxidative stress and tissue injury in rat liver.
Topics: Animals; Antioxidants; Betaine; Biomarkers; Carcinogens, Environmental; Carnosine; Chemical and Drug Induced Liver Injury; Dietary Supplements; Diethylnitrosamine; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Male; Oxidative Stress; Protein Carbonylation; Random Allocation; Rats, Wistar; Taurine; Tyrosine | 2016 |
Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.
Topics: Animals; Calcium Chloride; CHO Cells; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Ileum; KATP Channels; Mice; Molsidomine; Muscle Contraction; Muscle, Smooth; Mutation; Peroxynitrous Acid; Protein Processing, Post-Translational; Signal Transduction; Sulfides; Sulfonylurea Receptors; Transfection; Tyrosine | 2015 |
Inducible and endothelial nitric synthetase expression and nitrotyrosine accumulation in iris vasculature of patients with primary open-angle glaucoma: a pilot study.
Topics: Aged; Disease Progression; Female; Gene Expression Regulation, Enzymologic; Glaucoma, Open-Angle; Humans; Iris; Male; Manometry; Middle Aged; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenotype; Pilot Projects; Predictive Value of Tests; Tyrosine; Up-Regulation | 2015 |
Hippocampal Neuroprotection by Minocycline and Epigallo-Catechin-3-Gallate Against Cardiopulmonary Bypass-Associated Injury.
Topics: Adenosine Triphosphate; Animals; Apoptosis Inducing Factor; Brain Edema; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cardiopulmonary Bypass; Caspase 3; Catechin; Chromatography, High Pressure Liquid; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Minocycline; Neuroprotective Agents; Poly Adenosine Diphosphate Ribose; Swine; Tyrosine | 2015 |
Photoprotective effects of oxyresveratrol and Kuwanon O on DNA damage induced by UVA in human epidermal keratinocytes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Survival; Cells, Cultured; Deoxyguanosine; DNA Damage; Flavanones; Humans; Hydrogen Peroxide; Keratinocytes; Plant Extracts; Radiation-Protective Agents; Reactive Oxygen Species; Resorcinols; Stilbenes; Tumor Suppressor Protein p53; Tyrosine; Ultraviolet Rays | 2015 |
Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats.
Topics: Acetylcysteine; Animals; Ethidium; Free Radical Scavengers; Glutathione Peroxidase; Heart Failure; Heart Ventricles; Male; Malondialdehyde; Muscle, Skeletal; Myocardial Infarction; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2015 |
Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Animals; Antioxidants; Atrial Remodeling; Cardiomegaly; Cardiovascular System; Case-Control Studies; Cell Line; Deoxyguanosine; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Female; Glucagon-Like Peptide 1; Humans; Male; Mice; Middle Aged; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Palmitic Acid; Pilot Projects; Retrospective Studies; Tyrosine; Ventricular Remodeling | 2015 |
Leghemoglobin is nitrated in functional legume nodules in a tyrosine residue within the heme cavity by a nitrite/peroxide-dependent mechanism.
Topics: Glycine max; Heme; Hydrogen Peroxide; Leghemoglobin; Nitrates; Nitric Oxide; Nitrites; Nitrogen Dioxide; Oxidative Stress; Peroxynitrous Acid; Phaseolus; Protein Processing, Post-Translational; Tyrosine | 2015 |
Mechanisms of hyperhomocysteinemia induced skeletal muscle myopathy after ischemia in the CBS-/+ mouse model.
Topics: Animals; Antioxidants; Blotting, Western; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Mice, Inbred C57BL; Models, Biological; Muscle, Skeletal; Muscular Diseases; Nitric Oxide Donors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Protein Binding; Transcription Factors; Tyrosine | 2015 |
An altered pattern of myocardial histopathological and molecular changes underlies the different characteristics of type-1 and type-2 diabetic cardiac dysfunction.
Topics: Animals; Apoptosis; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fibrosis; Gene Expression Regulation; Heart; Heart Diseases; Hemodynamics; Immunohistochemistry; In Situ Nick-End Labeling; Male; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Zucker; RNA, Messenger; Transforming Growth Factor beta1; Tyrosine; Ventricular Function, Left | 2015 |
Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytokines; Disease Susceptibility; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glutathione; Hepatocytes; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Liver; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Receptor, Serotonin, 5-HT2B; Serotonin; Time Factors; Transcription, Genetic; Tryptophan Hydroxylase; Tyrosine | 2015 |
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclodextrins; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fullerenes; Glutathione; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Peroxynitrous Acid; Picrates; Protective Agents; Solubility; Static Electricity; Sulfonic Acids; Tyrosine | 2015 |
Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring.
Topics: Animals; Animals, Newborn; Antioxidants; Bilirubin; Catalase; Dose-Response Relationship, Drug; Fatty Liver; Female; Glutathione Peroxidase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lactation; Liver; Male; Maternal Exposure; Nicotine; Oxidative Stress; Protein Carbonylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serum Albumin; Signal Transduction; Superoxide Dismutase; Triglycerides; Tyrosine | 2015 |
N-acetylcysteine advancement of surfactant therapy in experimental meconium aspiration syndrome: possible mechanisms.
Topics: Acetylcysteine; Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; Cell Migration Assays, Leukocyte; Cytokines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Edema; Expectorants; Leukocyte Count; Lung; Meconium Aspiration Syndrome; Pilot Projects; Pulmonary Surfactants; Rabbits; Random Allocation; Respiratory Function Tests; Thiobarbituric Acid Reactive Substances; Tyrosine | 2014 |
Oxidative myocardial damage in human cocaine-related cardiomyopathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Blotting, Western; Cardiomyopathy, Dilated; Catalase; Cocaine-Related Disorders; Deoxyguanosine; Female; Heart Injuries; Humans; Male; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Reactive Oxygen Species; Retrospective Studies; Superoxide Dismutase; Tyrosine; Young Adult | 2015 |
Autophagy attenuates noise-induced hearing loss by reducing oxidative stress.
Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Autophagy; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Male; Mice; Microtubule-Associated Proteins; Oxidative Stress; Sirolimus; Tyrosine | 2015 |
Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice.
Topics: Angiotensin II; Animals; Catalase; Cytochrome P-450 CYP1B1; Disease Models, Animal; Drinking; Estradiol; Female; Fibrosis; Genotype; Hypertension; Kidney; Kidney Diseases; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Natriuresis; Oxidative Stress; Phenotype; Renin-Angiotensin System; Sex Factors; Superoxide Dismutase; Superoxides; Tyrosine; Urination | 2015 |
Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Down-Regulation; Female; Glycyrrhiza; Hyperglycemia; Inflammation; Isoflavones; Lipopolysaccharides; Liver; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phenols; Plant Roots; RNA, Messenger; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2015 |
Secondhand Smoking Is Associated With Vascular Inflammation.
Topics: Adult; Brachial Artery; Case-Control Studies; Cotinine; Endothelial Cells; Endothelium, Vascular; Female; Humans; Male; NF-kappa B; Nitric Oxide Synthase Type III; Oxidative Stress; Smoking; Tobacco Smoke Pollution; Tyrosine; Vasodilation; Young Adult | 2015 |
Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiomyopathies; Cyclooctanes; Disease Models, Animal; Doxorubicin; Gene Expression Regulation; Lignans; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Tyrosine; Ventricular Function, Left | 2015 |
Effect of the oestrogen receptor antagonist fulvestrant on the cirrhotic rat lung.
Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; Estradiol; Estrogen Receptor Antagonists; Fulvestrant; Heme Oxygenase (Decyclizing); Hepatopulmonary Syndrome; Liver Cirrhosis, Biliary; Lung; Macrophages; Male; Microfilament Proteins; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphoproteins; Phosphorylation; Rats, Wistar; Tyrosine; Vascular Endothelial Growth Factor A | 2015 |
Upregulation of inducible nitric oxide synthase and nitrotyrosine expression in primary knee osteoarthritis.
Topics: Aged; Case-Control Studies; Humans; Male; Middle Aged; Nitric Oxide Synthase Type II; Osteoarthritis, Knee; Synovial Fluid; Tyrosine; Up-Regulation | 2015 |
Organ-protective effects on the liver and kidney by minocycline in small piglets undergoing cardiopulonary bypass.
Topics: Animals; Apoptosis Inducing Factor; Cardiopulmonary Bypass; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Liver; Minocycline; Poly(ADP-ribose) Polymerases; Protective Agents; Swine; Tyrosine | 2015 |
Systemic oxidative profile after tumor removal and the tumor microenvironment in melanoma patients.
Topics: Adult; Aged; Female; Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Oxidative Stress; Skin Neoplasms; Tumor Microenvironment; Tyrosine; Young Adult | 2015 |
Sodium Butyrate Ameliorates L-Arginine-Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress.
Topics: Animals; Arginine; Butyric Acid; Down-Regulation; Fibrosis; Inflammation; Nitric Oxide Synthase Type II; Pancreas; Pancreatitis; Rats, Wistar; Tyrosine | 2015 |
Nitration of plant apoplastic proteins from cell suspension cultures.
Topics: Apoproteins; Apoptosis Regulatory Proteins; Arabidopsis; Cells, Cultured; Nicotiana; Nitric Oxide; Nitrogen; Plant Proteins; Tyrosine | 2015 |
Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus.
Topics: Aging; Animals; Fasting; Hippocampus; Lipopolysaccharides; Male; Neurodegenerative Diseases; Neurogenic Inflammation; Nitric Oxide; Nitric Oxide Synthase; Nucleotides, Cyclic; Oxidative Stress; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thiobarbiturates; Tyrosine | 2015 |
Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells.
Topics: Aging; Animals; Cells, Cultured; Humans; Leydig Cells; Male; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Testosterone; Tyrosine | 2015 |
Simultaneous Detection of 3-Nitrotyrosine and 3-Nitro-4-hydroxyphenylacetic Acid in Human Urine by Online SPE LC-MS/MS and Their Association with Oxidative and Methylated DNA Lesions.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenine; Adult; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deoxyguanosine; Dimethylnitrosamine; DNA Methylation; Guanine; Humans; Limit of Detection; Middle Aged; Nitrophenols; Oxidation-Reduction; Phenylacetates; Solid Phase Extraction; Tandem Mass Spectrometry; Tyrosine; Young Adult | 2015 |
Poststroke depression as a factor adversely affecting the level of oxidative damage to plasma proteins during a brain stroke.
Topics: Aged; Aged, 80 and over; Blood Proteins; Catalase; Depression; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Female; Humans; Male; Middle Aged; Oxidative Stress; Spectrophotometry; Stroke; Sulfhydryl Compounds; Tyrosine | 2015 |
Effect of higher frequency components and duration of vibration on bone tissue alterations in the rat-tail model.
Topics: Animals; Bone and Bones; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vibration | 2015 |
Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration.
Topics: Animals; Blotting, Western; Chagas Disease; Down-Regulation; Extracellular Matrix; Humans; Immunoprecipitation; Nitric Oxide; Protein Processing, Post-Translational; Signal Transduction; Tandem Mass Spectrometry; Trypanosoma cruzi; Tyrosine | 2015 |
Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice.
Topics: Aldehydes; Animals; Cornea; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Ganglia, Spinal; Glucose Tolerance Test; Mice; Mice, Inbred C57BL; Neural Conduction; Obesity; Tyrosine | 2015 |
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Endonucleases; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Resveratrol; Stilbenes; Tyrosine | 2015 |
Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway.
Topics: Acute Disease; Acute Kidney Injury; Amylases; Animals; Cytokines; Hydrogen; Kidney; Male; Neutrophil Infiltration; NF-kappa B; Oxidative Stress; Pancreatitis; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Sodium Chloride; Taurocholic Acid; Tyrosine | 2015 |
Nivalenol induces oxidative stress and increases deoxynivalenol pro-oxidant effect in intestinal epithelial cells.
Topics: Animals; Calcium Signaling; Cell Line; Epithelial Cells; Heme Oxygenase-1; Intestinal Mucosa; Intestines; Mitochondria; Mycotoxins; Oxidants; Oxidative Stress; Rats; Reactive Oxygen Species; Superoxides; Trichothecenes; Tyrosine | 2015 |
Evidence of nitrosative stress within hearts of patients dying of Tako-tsubo cardiomyopathy.
Topics: Age Factors; Aged; Biomarkers; Biopsy, Needle; Case-Control Studies; Cause of Death; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide Synthase; Risk Assessment; Severity of Illness Index; Sex Factors; Stress, Psychological; Survival Analysis; Takotsubo Cardiomyopathy; Tyrosine | 2015 |
Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock.
Topics: Acute Kidney Injury; Aging; Aldehydes; Animals; Antioxidants; Citrate (si)-Synthase; Hemorrhage; Kidney; Male; Mitochondria; Oxidative Stress; Rats; Rats, Long-Evans; Reactive Oxygen Species; Resuscitation; Resveratrol; Shock, Hemorrhagic; Stilbenes; Tyrosine | 2015 |
Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?
Topics: Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitrites; Protein Processing, Post-Translational; Sodium Nitrite; Superoxides; Tyrosine | 2015 |
Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Female; Flavonoids; Fruit; Humans; Ki-67 Antigen; Mammary Neoplasms, Experimental; MCF-7 Cells; Methylnitrosourea; Polyphenols; Rats; Stilbenes; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Endothelial Cells; Ethanolamines; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Lipopolysaccharides; Male; Malondialdehyde; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Palmitic Acids; Rats, Inbred Lew; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine; Uvea; Uveitis | 2015 |
The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania.
Topics: Acetylcysteine; Aldehydes; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Deferoxamine; Disease Models, Animal; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sleep Deprivation; Tyrosine | 2015 |
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients.
Topics: Aged; Biomarkers; Coronary Artery Disease; Female; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitrogen; Pilot Projects; Tyrosine; Urea | 2015 |
The administration of Fructus Schisandrae attenuates dexamethasone-induced muscle atrophy in mice.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Creatine; Creatine Kinase; Dexamethasone; Drugs, Chinese Herbal; Fibrosis; L-Lactate Dehydrogenase; Mice; Mice, Inbred ICR; Muscle Proteins; Muscle Strength; Muscle Tonus; Muscle, Skeletal; Muscular Atrophy; Myostatin; Nitric Oxide Synthase Type II; Oxymetholone; Phosphatidylinositol 3-Kinase; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A1; RNA, Messenger; Schisandra; Sirtuin 1; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; TRPV Cation Channels; Tyrosine; Ubiquitin-Protein Ligases | 2015 |
The effects of tempol on cyclophosphamide-induced oxidative stress in rat micturition reflexes.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Calcitonin Gene-Related Peptide; Cyclic N-Oxides; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; Oxidative Stress; Rats; Reactive Nitrogen Species; Reflex; Spin Labels; Substance P; Tyrosine; Urination | 2015 |
TPEN prevents rapid pacing-induced calcium overload and nitration stress in HL-1 myocytes.
Topics: Animals; Apoptosis; Atrial Fibrillation; Calcium; Cardiac Pacing, Artificial; Cell Line; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Ethylamines; Mice; Myocytes, Cardiac; Peroxynitrous Acid; Pyridines; Reactive Nitrogen Species; Signal Transduction; Tyrosine | 2015 |
Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Apoptosis; Cell Nucleus; Chymases; Cytokines; Disease Models, Animal; Disease Progression; Drug Interactions; Ethanolamines; Gene Expression Regulation; Kidney; Male; Mice; Nitrates; Nitrites; Oxidative Stress; Palmitic Acids; Reperfusion Injury; Risk Factors; Silymarin; Transcription Factor RelA; Tyrosine | 2015 |
NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.
Topics: Animals; Boronic Acids; Humans; Inflammation; Liver; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; NADPH Oxidases; NF-kappa B; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4; Tyrosine | 2015 |
Effect of Ambroxol and Beclomethasone on Lipopolysaccharide-Induced Nitrosative Stress in Bronchial Epithelial Cells.
Topics: Ambroxol; Beclomethasone; Bronchi; Cell Line; Chemokine CCL5; Epithelial Cells; Expectorants; Glucocorticoids; Humans; Interleukin-8; Lipopolysaccharides; Neutrophils; Nitric Oxide Synthase Type II; Nitrosation; Peroxidase; Respiratory Mucosa; Stress, Physiological; Tyrosine | 2015 |
Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury.
Topics: 25-Hydroxyvitamin D 2; Acute Kidney Injury; Animals; Apoptosis; Cholecalciferol; Glutathione; Kidney; Lipid Peroxidation; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Reactive Oxygen Species; Receptors, Calcitriol; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2015 |
Cardiac and renal nitrosative-oxidative stress after acute poisoning by a nerve agent Tabun.
Topics: Animals; Heart; Kidney; Male; Myocardium; Nerve Agents; Organophosphates; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2015 |
A novel mixed-mode solid phase extraction coupled with LC-MS/MS for the re-evaluation of free 3-nitrotyrosine in human plasma as an oxidative stress biomarker.
Topics: Biomarkers; Chromatography, Liquid; Humans; Limit of Detection; Oxidative Stress; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tyrosine | 2015 |
The Arabidopsis mitogen-activated protein kinase 6 is associated with γ-tubulin on microtubules, phosphorylates EB1c and maintains spindle orientation under nitrosative stress.
Topics: Anaphase; Arabidopsis; Arabidopsis Proteins; Butadienes; Cell Proliferation; Chromosome Segregation; Cytokinesis; Extracellular Signal-Regulated MAP Kinases; Kinetochores; Meristem; Microtubule-Associated Proteins; Microtubules; Mitogen-Activated Protein Kinases; Nitriles; Nitrosation; Phosphorylation; Plant Cells; Spindle Apparatus; Stress, Physiological; Telophase; Tubulin; Tyrosine | 2015 |
Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder.
Topics: Adolescent; Autism Spectrum Disorder; Biomarkers; Child; Child, Preschool; Communication Disorders; Diagnostic and Statistical Manual of Mental Disorders; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Tyrosine | 2015 |
Effects and clinical significance of pentoxifylline on the oxidative stress of rats with diabetic nephropathy.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Regulation; Kidney; Malondialdehyde; Oxidative Stress; Pentoxifylline; Rats; Streptozocin; Superoxide Dismutase; Tyrosine | 2015 |
Oxidative stress in murine Theiler's virus-induced temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Glutathione; Glutathione Disulfide; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Theilovirus; Tyrosine | 2015 |
Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; HSP90 Heat-Shock Proteins; Mitochondria; PC12 Cells; Protein Processing, Post-Translational; Protein Transport; Rats; Tyrosine | 2015 |
Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain.
Topics: Aldehydes; Animals; Body Weight; Chemokine CCL2; Connective Tissue Growth Factor; Disease Progression; Disease Resistance; Dose-Response Relationship, Drug; Doxorubicin; Fibrosis; Kidney; Male; Membrane Proteins; Oxidative Stress; Proteinuria; Rats; Reactive Nitrogen Species; Species Specificity; Transforming Growth Factor beta1; Tyrosine | 2015 |
Neonatal exposure to mild hyperoxia causes persistent increases in oxidative stress and immune cells in the lungs of mice without altering lung structure.
Topics: Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; Female; Heme Oxygenase-1; Hyperoxia; Inflammation; Macrophages, Alveolar; Membrane Proteins; Mice; Mice, Inbred C57BL; Oxidative Stress; Oxygen; Pulmonary Alveoli; Tyrosine | 2015 |
Glutathione Supplementation Attenuates Oxidative Stress and Improves Vascular Hyporesponsiveness in Experimental Obstructive Jaundice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Ducts; Bilirubin; Glutathione; Interleukin-1beta; Jaundice, Obstructive; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2015 |
The link between mitochondrial complex I and brain-derived neurotrophic factor in SH-SY5Y cells--The potential of JNX1001 as a therapeutic agent.
Topics: Bipolar Disorder; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electron Transport Complex I; Humans; Neurons; Neuroprotective Agents; Protein Carbonylation; Rotenone; Signal Transduction; Spirostans; Tyrosine | 2015 |
Protective effects of SS31 on t‑BHP induced oxidative damage in 661W cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Cell Line, Transformed; Cell Survival; Cytochromes c; Deoxyguanosine; Membrane Potential, Mitochondrial; Mice; Mitochondria; Oligopeptides; Oxidants; Oxidative Stress; Reactive Oxygen Species; Retinal Cone Photoreceptor Cells; tert-Butylhydroperoxide; Tyrosine | 2015 |
Dual selective nitration in Arabidopsis: Almost exclusive nitration of PsbO and PsbP, and highly susceptible nitration of four non-PSII proteins, including peroxiredoxin II E.
Topics: Arabidopsis Proteins; Chloroplast Proteins; Electrophoresis, Gel, Two-Dimensional; Nitro Compounds; Photosystem II Protein Complex; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2015 |
Troponin in diabetic patients with and without chronic coronary artery disease.
Topics: Aged; Biomarkers; Case-Control Studies; Cholesterol, LDL; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Oxidation-Reduction; Peroxidase; Risk Factors; Troponin C; Tyrosine | 2015 |
Prolactin- and testosterone-induced carboxypeptidase-D correlates with increased nitrotyrosines and Ki67 in prostate cancer.
Topics: Carboxypeptidases; Humans; Ki-67 Antigen; Male; Neoplasm Grading; Nitric Oxide Synthase Type III; Phosphorylation; Prolactin; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Receptors, Androgen; Receptors, Prolactin; Signal Transduction; STAT5 Transcription Factor; Testosterone; Tyrosine; Up-Regulation | 2015 |
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice.
Topics: Aldehydes; Allopurinol; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid; Xanthine Dehydrogenase | 2015 |
Peroxynitrite and fibrinolytic system-The effects of peroxynitrite on t-PA-induced plasmin activity.
Topics: Amino Acid Sequence; Enzyme Activation; Fibrinolysin; Fibrinolysis; Humans; Models, Molecular; Molecular Sequence Data; Oxidative Stress; Peroxynitrous Acid; Plasminogen; Protein Binding; Protein Conformation; Sequence Alignment; Tissue Plasminogen Activator; Tyrosine | 2015 |
Angiotensin and mineralocorticoid receptor antagonism attenuates cardiac oxidative stress in angiotensin II-infused rats.
Topics: Adrenal Glands; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Eplerenone; Heart Diseases; Hypertension; Lipid Peroxidation; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Oxidative Stress; Rats, Sprague-Dawley; Renin-Angiotensin System; Signal Transduction; Spironolactone; Time Factors; Tyrosine | 2015 |
Tempol alleviates intracerebral hemorrhage-induced brain injury possibly by attenuating nitrative stress.
Topics: Animals; Antioxidants; Apoptosis; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Cerebral Hemorrhage; Collagenases; Cyclic N-Oxides; Disease Models, Animal; Male; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Spin Labels; Tyrosine; Zonula Occludens-1 Protein | 2015 |
Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis.
Topics: Animals; Antioxidants; Biomarkers; Diet, Western; Dietary Supplements; Duodenum; Endotoxins; Female; Glutamine; Intestinal Mucosa; Lipid Peroxidation; Liver; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Plasminogen Activator Inhibitor 1; Receptor, Insulin; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha; Tyrosine | 2015 |
Diet-induced obesity and kidney disease - In search of a susceptible mouse model.
Topics: Animals; Diet; Disease Models, Animal; Insulin Resistance; Lipid Metabolism; Male; Mice; Mitochondria; Nitric Oxide Synthase Type II; Obesity; Oxidative Stress; Renal Insufficiency, Chronic; Tyrosine | 2016 |
S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion.
Topics: Analysis of Variance; Animals; Brain; Brain Ischemia; Calpain; Chronic Disease; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glycogen Synthase Kinase 3; Neuroprotective Agents; Phosphorylation; Rats; S-Nitrosoglutathione; Synaptosomes; tau Proteins; Tyrosine | 2015 |
Tailored 96-well μElution solid-phase extraction combined with UFLC-MS/MS: a significantly improved approach for determination of free 3-nitrotyrosine in human urine.
Topics: Biomarkers; Chromatography, Liquid; Humans; Limit of Detection; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tyrosine | 2015 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Tyrosine | 2015 |
Prion Protein Protects against Renal Ischemia/Reperfusion Injury.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Heme Oxygenase-1; Kidney; Kidney Diseases; Mice; Mice, Knockout; Mitochondria; Oxidative Stress; Prions; Reperfusion Injury; Tyrosine | 2015 |
Inactivation of PYR/PYL/RCAR ABA receptors by tyrosine nitration may enable rapid inhibition of ABA signaling by nitric oxide in plants.
Topics: Abscisic Acid; Arabidopsis; Arabidopsis Proteins; Nitric Oxide; Phosphoprotein Phosphatases; Protein Phosphatase 2C; Signal Transduction; Tyrosine | 2015 |
Antioxidant action of six Trifolium species in blood platelet experimental system in vitro.
Topics: Antioxidants; Blood Platelets; Dose-Response Relationship, Drug; Humans; Lipid Peroxides; Oxidative Stress; Peroxynitrous Acid; Phenols; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Thiobarbituric Acid Reactive Substances; Trifolium; Tyrosine | 2015 |
Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes.
Topics: Aged; Aged, 80 and over; Blood Coagulation; Blood Glucose; Diabetes Mellitus, Type 2; Dinoprost; Female; Fibrin; Fibrinolysis; Glomerular Filtration Rate; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Kinetics; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Oxygen; Permeability; Receptor for Advanced Glycation End Products; Recombinant Proteins; Surveys and Questionnaires; Tissue Plasminogen Activator; Tyrosine | 2015 |
Increased oxidative stress contributes to cardiomyocyte dysfunction and death in patients with Fabry disease cardiomyopathy.
Topics: Adult; Aged; Apoptosis; Fabry Disease; Female; Humans; Male; Middle Aged; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Tyrosine | 2015 |
Role of thioredoxin nitration in bleomycin-induced pulmonary fibrosis in rats.
Topics: Animals; Bleomycin; Disease Models, Animal; Humans; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Lung; Male; Nitrates; Oxidation-Reduction; Pulmonary Fibrosis; Rats; Rats, Wistar; Thioredoxins; Tyrosine | 2016 |
Differential Contributions of Alcohol and the Nicotine-Derived Nitrosamine Ketone (NNK) to Insulin and Insulin-Like Growth Factor Resistance in the Adolescent Rat Brain.
Topics: Acetylcholinesterase; Animals; Atrophy; Dinoprost; Drug Synergism; Ethanol; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin Resistance; Male; Maze Learning; Nicotine; Nitrosamines; Oxidative Stress; Phosphorylation; Protein Carbonylation; Rats; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Somatomedins; Spatial Learning; tau Proteins; Temporal Lobe; Tyrosine | 2015 |
Treadmill Exercise Attenuates Retinal Oxidative Stress in Naturally-Aged Mice: An Immunohistochemical Study.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Deoxyguanosine; Lysine; Male; Mice; Oxidative Stress; Physical Conditioning, Animal; Retina; Tyrosine | 2015 |
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Proliferation; Cell Shape; Cell Transformation, Neoplastic; Diethylnitrosamine; Hep G2 Cells; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms, Experimental; Male; Mice, Knockout; Mitochondria; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine; Wnt Signaling Pathway | 2015 |
Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats.
Topics: Animals; Blood Pressure; Body Weight; Creatinine; Disease Models, Animal; Endothelium, Vascular; Erythropoietin; Femoral Artery; Heart Rate; Hemoglobins; Kidney Function Tests; Male; NADPH Oxidase 4; NADPH Oxidases; Nephrectomy; Nitric Oxide Synthase Type III; Nitroglycerin; Polyethylene Glycols; Proteinuria; Rats; Renal Insufficiency, Chronic; Tyrosine; Ultrasonography; Vasodilation | 2015 |
The effects of repetitive vibration on sensorineural function: biomarkers of sensorineural injury in an animal model of metabolic syndrome.
Topics: Animals; Biophysics; Chemokine CCL2; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Interleukin-1beta; Male; Metabolic Syndrome; Neuralgia; Nitric Oxide Synthase Type I; Rats; Rats, Zucker; Receptors, Adrenergic, alpha-2; RNA, Messenger; Time Factors; Transcutaneous Electric Nerve Stimulation; Tyrosine; Vibration | 2015 |
Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus.
Topics: Altitude Sickness; Animals; Antioxidants; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia; Male; Melatonin; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Tyrosine | 2015 |
Nitroproteins in Human Astrocytomas Discovered by Gel Electrophoresis and Tandem Mass Spectrometry.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Astrocytoma; Blotting, Western; Brain; Brain Chemistry; Brain Neoplasms; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; Molecular Sequence Data; Proteins; Tandem Mass Spectrometry; Tyrosine | 2015 |
[Effects of tyrosine oxidation products on redox state in myocardium of rats].
Topics: Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; Heart; Male; Malondialdehyde; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Thioctic Acid; Transcription Factor AP-1; Tyrosine | 2015 |
Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart.
Topics: Animals; Apoptosis; Cardiotonic Agents; Catalase; Cell Line; Diabetes Mellitus, Experimental; Inflammation; Mice, Transgenic; Myocardium; NF-kappa B; Nitriles; Nitrosation; Organ Specificity; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Sulfones; Tyrosine | 2015 |
Heat Shock Protein 27 Response to Wrestling Training in Relation to the Muscle Damage and Inflammation.
Topics: Adolescent; Creatine Kinase; HSP27 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Inflammation; Interleukin-1beta; Male; Muscle, Skeletal; Nitric Oxide; Physical Conditioning, Human; Tumor Necrosis Factor-alpha; Tyrosine; Wrestling; Young Adult | 2017 |
Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cells.
Topics: Acetylation; Animals; Cells, Cultured; DNA, Mitochondrial; Dose-Response Relationship, Drug; Electron Transport Chain Complex Proteins; Endothelial Cells; Gestational Age; HSP90 Heat-Shock Proteins; Microtubules; Mitochondria; Nitric Oxide Synthase Type III; Oxygen Consumption; Protein Binding; Pulmonary Artery; Sheep; Superoxides; Tyrosine | 2016 |
[DYNAMICS OF NITROGEN OXIDE METABOLITES IN THE PLASMA AND ASCITES DURING ZAJDEL HEPATOMA GROWTH IN VIVO].
Topics: Animals; Ascitic Fluid; Liver Neoplasms, Experimental; Nitrogen Oxides; Rats; Tyrosine | 2015 |
Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.
Topics: Animals; Diabetic Nephropathies; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Kallikreins; Kidney; Kidney Function Tests; Male; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidase 4; NADPH Oxidases; Neovascularization, Pathologic; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Serpins; Transforming Growth Factor beta; Tyrosine; Vascular Endothelial Growth Factor A | 2016 |
Psychological stress-induced catecholamines accelerates cutaneous aging in mice.
Topics: Animals; Catecholamines; Dermis; Leukocyte Elastase; Lipid Peroxidation; Male; Matrix Metalloproteinase 8; Mice; Reactive Oxygen Species; Skin Aging; Stress, Psychological; Tissue Inhibitor of Metalloproteinase-1; Tyrosine | 2015 |
Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cholesterol; Diet, High-Fat; Disease Models, Animal; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glyceryl Ethers; Inflammation Mediators; Lysophospholipids; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Oxidation-Reduction; Oxidative Stress; Plaque, Atherosclerotic; Plasmalogens; Tyrosine; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2015 |
Oxidative Modifications of Protein Tyrosyl Residues Are Increased in Plasma of Human Subjects with Interstitial Lung Disease.
Topics: Animals; Biomarkers; Cells, Cultured; Female; Humans; Lung Diseases, Interstitial; Male; Mice; Mice, Inbred C57BL; Middle Aged; Oxidative Stress; Tandem Mass Spectrometry; Tyrosine | 2016 |
Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning.
Topics: Animals; Apoptosis Regulatory Proteins; Arrhythmias, Cardiac; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Beclin-1; Heat-Shock Proteins; Hyperglycemia; Intracellular Signaling Peptides and Proteins; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sequestosome-1 Protein; Severity of Illness Index; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Tyrosine; Ubiquitin-Activating Enzymes | 2015 |
Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Cytochrome P-450 CYP1A2; Deoxyguanosine; Diet; Disease Models, Animal; Humans; Imidazoles; Ki-67 Antigen; Male; Mice, Transgenic; NF-E2-Related Factor 2; Phosphorylation; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tocopherols; Tyrosine | 2016 |
Potential Biomarker of Myofibrillar Protein Oxidation in Raw and Cooked Ham: 3-Nitrotyrosine Formed by Nitrosation.
Topics: Animals; Biomarkers; Cooking; Hot Temperature; Meat Products; Muscle Proteins; Myofibrils; Nitrosation; Oxidation-Reduction; Sodium Nitrite; Swine; Tyrosine | 2015 |
N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats.
Topics: Acetylcysteine; Animals; Antioxidants; Blotting, Western; Comet Assay; Disease Models, Animal; DNA Damage; Gastric Mucosa; Hypertension, Portal; Immunohistochemistry; Male; Neovascularization, Pathologic; Nitric Oxide Synthase Type III; Portal Pressure; Rats, Wistar; Stomach; Tyrosine; Vascular Endothelial Growth Factor A; Vasodilation | 2015 |
The mechanisms associated with the development of hypertension after exposure to lead, mercury species or their mixtures differs with the metal and the mixture ratio.
Topics: Animals; Blood Pressure; Drinking Water; Glutathione; Hypertension; Kidney Diseases; Lead; Liver; Male; Mercury; Methylmercury Compounds; Oxidative Stress; Rats; Rats, Wistar; Renin-Angiotensin System; Tyrosine | 2016 |
Potential renoprotective effects of piceatannol in ameliorating the early-stage nephropathy associated with obesity in obese Zucker rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Cell Adhesion Molecules; Dietary Supplements; Fibrosis; Kidney; Lipid Peroxidation; Male; Obesity; Organ Size; Oxidative Stress; Random Allocation; Rats, Zucker; Renal Insufficiency; Severity of Illness Index; Stilbenes; Thiobarbituric Acid Reactive Substances; Tyrosine | 2016 |
Intraventricular apolipoprotein ApoJ infusion acts protectively in Traumatic Brain Injury.
Topics: Aldehydes; Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cerebral Cortex; Clusterin; Disease Models, Animal; Infusions, Intraventricular; Male; Mice, Inbred C57BL; Neuroprotective Agents; Tyrosine | 2016 |
Improved Incorporation of Noncanonical Amino Acids by an Engineered tRNA(Tyr) Suppressor.
Topics: Amino Acids; Archaeal Proteins; Directed Molecular Evolution; Escherichia coli; Green Fluorescent Proteins; Kinetics; Methanocaldococcus; Mutation; Nucleotides; Recombinant Proteins; Tyrosine; Tyrosine-tRNA Ligase | 2016 |
New findings on the in vivo antioxidant activity of Curcuma longa extract by an integrated (1)H NMR and HPLC-MS metabolomic approach.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Allantoin; Animals; Antioxidants; Chromatography, High Pressure Liquid; Curcuma; Deoxyguanosine; Female; Male; Mass Spectrometry; Metabolomics; Methylamines; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Tyrosine | 2016 |
Intact FGF23 and α-Klotho during acute inflammation/sepsis in CKD patients.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Calcitonin; Calcitriol; Female; Ferritins; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glucuronidase; Humans; Inflammation; Interleukin-6; Iron; Klotho Proteins; Male; Middle Aged; Oxidative Stress; Parathyroid Hormone; Prospective Studies; Renal Insufficiency, Chronic; Sepsis; Tumor Necrosis Factor-alpha; Tyrosine; Vitamin D | 2016 |
Solanum torvum Swartz. fruit attenuates cadmium-induced liver and kidney damage through modulation of oxidative stress and glycosylation.
Topics: Animals; Antioxidants; Biomarkers; Cadmium; Environmental Pollutants; Fruit; Glycosylation; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Solanum; Tyrosine | 2016 |
Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine.
Topics: alpha-Synuclein; Amino Acid Sequence; Fluorenes; Hydrolysis; Oxidative Stress; Peptides; Prions; Trifluoroacetic Acid; Tyrosine | 2016 |
Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Liver; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Quercetin; RNA, Messenger; Sulfotransferases; Tyrosine | 2016 |
Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Echocardiography; Female; Interleukin-10; Interleukin-6; Mice, Inbred C57BL; Myocardium; Nitric Oxide Synthase Type II; Nitrites; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability.
Topics: Animals; Blotting, Western; Brain; Cytosol; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Intellectual Disability; Isoenzymes; Lipopolysaccharides; Mice, Knockout; Models, Biological; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Culture Techniques; Transcription Factor RelA; Tyrosine | 2016 |
FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy women.
Topics: Adult; Antioxidants; Bed Rest; Biomarkers; Catalase; Female; Glutathione Peroxidase; Humans; Hypoxia; Malondialdehyde; Nitrites; Nitrogen Oxides; Oxidative Stress; Superoxide Dismutase; Tyrosine; Uric Acid; Women's Health | 2016 |
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation.
Topics: Animals; Azoles; Blood Pressure; Carotid Body; Diastole; Hypertension; Hypoxia; Isoindoles; Male; Neuronal Plasticity; Organoselenium Compounds; Peroxynitrous Acid; Rats, Sprague-Dawley; Systole; Tyrosine | 2016 |
The neuroprotective effects of preconditioning exercise on brain damage and neurotrophic factors after focal brain ischemia in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Caspase 3; Cytokines; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Male; Midkine; Nerve Growth Factors; Physical Conditioning, Animal; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley; Tyrosine | 2016 |
Oxidative stress markers are elevated in exhaled breath condensate of workers exposed to nanoparticles during iron oxide pigment production.
Topics: Adult; Aldehydes; Biomarkers; Breath Tests; Dinoprost; Ferric Compounds; Guanosine; Humans; Male; Malondialdehyde; Middle Aged; Nanoparticles; Oxidative Stress; Tandem Mass Spectrometry; Tyrosine | 2016 |
Protective Effects of Ultramicronized Palmitoylethanolamide (PEA-um) in Myocardial Ischaemia and Reperfusion Injury in VIVO.
Topics: Amides; Animals; Ethanolamines; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; Mice; Mice, Knockout; Microtomy; Myocardial Ischemia; Myocardial Reperfusion Injury; P-Selectin; Palmitic Acids; PPAR alpha; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
TLR-7 agonist attenuates airway reactivity and inflammation through Nrf2-mediated antioxidant protection in a murine model of allergic asthma.
Topics: Animals; Antioxidants; Asthma; Bronchoalveolar Lavage; Imidazoles; Immunoblotting; Inflammation; Lipid Peroxides; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Superoxide Dismutase; Toll-Like Receptor 7; Tyrosine | 2016 |
Anticancer efficacy of a nitric oxide-modified derivative of bifendate against multidrug-resistant cancer cells.
Topics: Antineoplastic Agents; Apoptosis; ATP-Binding Cassette Transporters; Biphenyl Compounds; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; K562 Cells; Mitochondria; NF-kappa B; Nitric Oxide; Proto-Oncogene Proteins c-akt; RNA, Messenger; Tyrosine | 2016 |
RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Disease Models, Animal; Female; Hypochlorous Acid; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pneumonia; Pulmonary Fibrosis; rho-Associated Kinases; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Tyrosine | 2016 |
Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber's Hereditary Optic Neuropathy Cells.
Topics: Adenosine Triphosphate; Adult; Cell Survival; Female; Flow Cytometry; Fluorometry; Humans; Leukocytes, Mononuclear; Lymphocytes; Mutation; Nitrites; Nitrogen; Optic Atrophy, Hereditary, Leber; Oxidative Stress; Oxygen; Oxygen Consumption; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2016 |
PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy.
Topics: Animals; Benzamides; Constriction, Pathologic; Cyclooxygenase 2; Hyperalgesia; Inflammation; Male; NAD; Neuritis; Neuroprotective Agents; Oxidative Stress; Pain Measurement; Peripheral Nervous System Diseases; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Sprague-Dawley; Sensation; Tyrosine; Walking | 2016 |
Quantitative assessment of placental perfusion by contrast-enhanced ultrasound in macaques and human subjects.
Topics: Algorithms; Animals; Caspase 3; Chorionic Villi; Contrast Media; Female; HSP70 Heat-Shock Proteins; Humans; Kinetics; Macaca; Microbubbles; Placental Circulation; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Signal Processing, Computer-Assisted; Trophoblasts; Tyrosine; Ultrasonography | 2016 |
Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases.
Topics: Animals; Female; Foot Diseases; Gastrointestinal Diseases; Hoof and Claw; Horse Diseases; Horses; Male; Oxidative Stress; Superoxide Dismutase; Tyrosine | 2016 |
[Passive smoking damages blood vessels the same as active smoking].
Topics: Endothelium, Vascular; Humans; NF-kappa B; Nitric Oxide Synthase Type III; Oxidative Stress; Smoking; Tobacco Smoke Pollution; Tyrosine; Vasculitis | 2015 |
Cyanidin-3-glucoside and its phenolic acid metabolites attenuate visible light-induced retinal degeneration in vivo via activation of Nrf2/HO-1 pathway and NF-κB suppression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anthocyanins; Antioxidants; Apoptosis; Coumaric Acids; Cytokines; Deoxyguanosine; Glucosides; Heme Oxygenase-1; Hydroxybenzoates; In Situ Nick-End Labeling; Light; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rabbits; Retina; Retinal Degeneration; Signal Transduction; Tyrosine; Up-Regulation | 2016 |
Epigallocatechin gallate attenuates cardiopulmonary bypass-associated lung injury.
Topics: Animals; Antioxidants; Apoptosis Inducing Factor; Camellia sinensis; Cardiopulmonary Bypass; Catechin; Drug Evaluation, Preclinical; Female; Immunohistochemistry; Lung; Lung Injury; Male; Phytotherapy; Plant Extracts; Poly Adenosine Diphosphate Ribose; Swine; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
Intravenous iron sucrose reverses anemia-induced cardiac remodeling, prevents myocardial fibrosis, and improves cardiac function by attenuating oxidative/nitrosative stress and inflammation.
Topics: Anemia; Animals; Cardiotonic Agents; Ferric Compounds; Ferric Oxide, Saccharated; Fibrosis; Glucaric Acid; Inflammation; Infusions, Intravenous; Male; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine; Ventricular Remodeling | 2016 |
[Effects of artesunate on cigarette smoke-induced lung oxidative damage in mice and the expression of Nrf2 and the possible mechanism].
Topics: Acute Lung Injury; Animals; Artemisinins; Artesunate; Bronchoalveolar Lavage Fluid; Female; Interleukin-8; Lung; Malondialdehyde; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Nicotiana; Oxidation-Reduction; Random Allocation; Smoking; Tobacco Smoke Pollution; Tyrosine | 2016 |
Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice.
Topics: Adiponectin; Animals; Antibodies, Neutralizing; Apolipoproteins E; Arterioles; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Phenotype; Scavenger Receptors, Class E; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Vasodilation; Vasodilator Agents | 2015 |
Increased Exhaled 8-Isoprostane and Interleukin-6 in Patients with Helicobacter pylori Infection.
Topics: Adult; Breath Tests; Dinoprost; Female; Helicobacter Infections; Humans; Interleukin-6; Male; Middle Aged; Tyrosine | 2016 |
Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2'-deoxyguanosine and Nitrotyrosine in Melanoma.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Cell Line, Tumor; Deoxyguanosine; Female; Humans; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Kelch-Like ECH-Associated Protein 1; Male; Melanoma; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Tyrosine | 2016 |
Effect of maximal-intensity exercise on systemic nitro-oxidative stress in men and women.
Topics: Adult; Antioxidants; Exercise; Female; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Male; Oxidative Stress; Sex Characteristics; Tyrosine; Young Adult | 2017 |
Label-free detection of 3-nitro-l-tyrosine with nickel-doped graphene localized surface plasmon resonance biosensor.
Topics: Biomarkers; Enzyme-Linked Immunosorbent Assay; Gold; Graphite; Humans; Limit of Detection; Nanostructures; Neurodegenerative Diseases; Nickel; Surface Plasmon Resonance; Tyrosine | 2017 |
[Peripheral Blood Lymphocytes Mitochondrial Function in Children with Traumatic Brain Injury].
Topics: Brain Injuries; Child; Child, Preschool; Female; Glasgow Coma Scale; Humans; Infant; Lymphocytes; Male; Mitochondria; NADH Dehydrogenase; Nitric Oxide; Oxidative Phosphorylation; Statistics as Topic; Succinate Dehydrogenase; Tyrosine | 2015 |
A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation.
Topics: Active Transport, Cell Nucleus; Administration, Oral; Amides; Animals; Carrageenan; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Drug Compounding; Drug Interactions; Edema; Ethanolamines; Gene Expression Regulation, Enzymologic; Glucosides; Hyperalgesia; Inflammation; Male; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Palmitic Acids; Proteolysis; Rats; Rats, Sprague-Dawley; Stilbenes; Superoxide Dismutase; Transcription Factor RelA; Tyrosine | 2016 |
The memory enhancement effect of Kai Xin San on cognitive deficit induced by simulated weightlessness in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcholinesterase; Animals; Avoidance Learning; Brain; Choline O-Acetyltransferase; Cognition Disorders; Deoxyguanosine; Disease Models, Animal; Drugs, Chinese Herbal; Escape Reaction; Hindlimb Suspension; Male; Memory; Neuroprotective Agents; Phytotherapy; Rats, Sprague-Dawley; Reactive Oxygen Species; Swimming; Tyrosine; Weightlessness | 2016 |
Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction.
Topics: Animals; Arginase; Disease Models, Animal; Female; Fetal Growth Retardation; Heme Oxygenase-1; Kidney; Kidney Glomerulus; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Placental Circulation; Pregnancy; Rabbits; Reactive Oxygen Species; RNA, Messenger; Transcriptome; Tyrosine | 2016 |
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Topics: Acetylation; Animals; Arginase; Biomarkers; Cell Count; Dendritic Cells; Histones; Interleukin-4; Leishmania major; Leishmaniasis; Macrophages; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid Cells; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Phosphorylation; STAT6 Transcription Factor; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2016 |
Effect of the oral iron chelator deferiprone in diabetic nephropathy rats.
Topics: Administration, Oral; Animals; Blotting, Western; Chemokine CCL2; Cyclooxygenase 2; Deferiprone; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Carbohydrates; Dose-Response Relationship, Drug; Gene Expression; Immunohistochemistry; Iron Chelating Agents; Kidney; Male; Matrix Metalloproteinase 9; Microscopy, Electron, Transmission; NF-kappa B; Protective Agents; Pyridones; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinase-1; Tyrosine | 2017 |
Effects of Early Post-Ischemic Reperfusion and tPA on Cerebrovascular Function and Nitrosative Stress in Female Rats.
Topics: Actins; Amides; Animals; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Middle Cerebral Artery; Muscle, Smooth; Neutrophils; Ovariectomy; Pyridines; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Tissue Plasminogen Activator; Tyrosine | 2016 |
Role of Oxygen Free Radicals, Nitric Oxide and Mitochondria in Mediating Cardiac Alterations During Liver Cirrhosis Induced by Thioacetamide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Heart Diseases; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Mitochondria, Heart; Mitochondrial Swelling; Myocytes, Cardiac; Nitrates; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Thioacetamide; Time Factors; Tyrosine | 2017 |
Electrode Potentials of l-Tryptophan, l-Tyrosine, 3-Nitro-l-tyrosine, 2,3-Difluoro-l-tyrosine, and 2,3,5-Trifluoro-l-tyrosine.
Topics: Dipeptides; Electrochemical Techniques; Electrodes; Hydrocarbons, Fluorinated; Tyrosine | 2016 |
Sodium nitroprusside has leishmanicidal activity independent of iNOS.
Topics: Animals; Immunohistochemistry; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitroprusside; Trypanocidal Agents; Tyrosine | 2016 |
Impact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring.
Topics: Animals; Antioxidants; Cytokines; Encephalitis; Female; Gene Expression Regulation; Male; Maternal Exposure; Mice; Mice, Inbred BALB C; Nicotiana; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Smoke; Toll-Like Receptor 4; Tyrosine | 2016 |
Stabilizing the cold plasma-stimulated medium by regulating medium's composition.
Topics: Antineoplastic Agents; Culture Media; Cysteine; Free Radicals; Freezing; Helium; Humans; Hydrogen Peroxide; Methionine; Neoplasms; Radiation; Tyrosine | 2016 |
Gradually increased oxygen administration promoted survival after hemorrhagic shock.
Topics: Alanine Transaminase; Animals; Blood Gas Analysis; Hemodynamics; Oxidative Stress; Oxygen; Rats; Shock, Hemorrhagic; Survival Analysis; Time Factors; Tyrosine | 2016 |
Oxidative Stress in the Developing Rat Brain due to Production of Reactive Oxygen and Nitrogen Species.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Glycosylation; Hydrogen Peroxide; Lipid Peroxidation; Lysine; Microscopy, Fluorescence; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxides; Tyrosine | 2016 |
Hearing impairment, cochlear morphology, and peroxynitrite (ONOO(-)) formation in adult and aging NOS II knockout mice.
Topics: Aging; Animals; Cochlea; Female; Hearing Loss; Immunohistochemistry; Mice, Knockout; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Tyrosine | 2016 |
Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Immunohistochemistry; Infrared Rays; Mice; Microscopy, Confocal; Neurodegenerative Diseases; Oxidative Stress; Phototherapy; Random Allocation; Rats; Spinal Cord; Spinal Cord Injuries; Tissue Culture Techniques; Tyrosine | 2016 |
Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Febuxostat; Hypertension; Male; Oxidative Stress; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2016 |
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta, Thoracic; Blotting, Western; Collagen Type IV; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Fibronectins; Immunohistochemistry; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin; Renin-Angiotensin System; Superoxide Dismutase; Transforming Growth Factor beta; Tyrosine | 2016 |
Peroxynitrite-induced structural perturbations in human IgG: A physicochemical study.
Topics: Arthritis, Rheumatoid; Calorimetry, Differential Scanning; Circular Dichroism; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G; Inflammation; Light; Microscopy, Fluorescence; Oxygen; Peroxynitrous Acid; Protein Structure, Secondary; Scattering, Radiation; Sepharose; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Temperature; Tryptophan; Tyrosine | 2016 |
[Effect of Resveratrol Preconditioning on Myocardial Dysfunction after Cardiac Arrest in Rats].
Topics: Animals; Disease Models, Animal; Heart; Heart Arrest; Ischemic Preconditioning; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Tyrosine | 2016 |
Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: Experimental rat injury model.
Topics: Aldehydes; Animals; Blast Injuries; Blood-Brain Barrier; Bradycardia; Brain; Brain Injuries, Traumatic; Explosions; Lung Injury; Male; Microvessels; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitrosative Stress; Rats, Sprague-Dawley; Tyrosine | 2016 |
BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Ginsenosides; Molecular Docking Simulation; Oxidative Stress; Peroxynitrous Acid; Protease Inhibitors; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tyrosine | 2016 |
Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antigens, CD; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Fumarates; Gene Expression Regulation; Humans; Maleates; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinsonian Disorders; Rats; Signal Transduction; Tyrosine | 2016 |
The evaluation of local oxidative/nitrosative stress in patients with pityriasis versicolor: a preliminary study.
Topics: Adult; Antioxidants; Biomarkers; Catalase; Enzyme-Linked Immunosorbent Assay; Female; Humans; Keratinocytes; Malassezia; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Pilot Projects; Reactive Nitrogen Species; Reactive Oxygen Species; Skin; Stress, Physiological; Tinea Versicolor; Tyrosine; Young Adult | 2016 |
Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.
Topics: alpha-Synuclein; Animals; Brain Infarction; Brain Ischemia; Caspase 3; Death-Associated Protein Kinases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; RNA, Small Interfering; Stroke; Tyrosine | 2016 |
Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China.
Topics: Aged; Biomarkers; C-Reactive Protein; China; Cognitive Dysfunction; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dinoprost; Dipeptidyl Peptidase 4; Female; Glycated Hemoglobin; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Odds Ratio; Oxidative Stress; Risk Factors; Tyrosine | 2016 |
Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model.
Topics: Animals; Animals, Newborn; Asphyxia; Biomarkers; Brain; Disease Models, Animal; Female; Ischemic Postconditioning; Neuroglia; Nitric Oxide Synthase; Oxidative Stress; Sus scrofa; Tyrosine | 2016 |
Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice.
Topics: Aldehydes; Animals; Aorta; Aortic Diseases; Apoptosis; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Fibroblast Growth Factors; Fibrosis; Gene Deletion; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Phenotype; Signal Transduction; Time Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Remodeling | 2015 |
Nitrative Stress Participates in Endothelial Progenitor Cell Injury in Hyperhomocysteinemia.
Topics: Animals; Endothelial Progenitor Cells; Female; Flow Cytometry; Hyperhomocysteinemia; Immunohistochemistry; In Situ Nick-End Labeling; Random Allocation; Rats, Wistar; Tyrosine | 2016 |
Nano optical sensor binuclear Pt-2-pyrazinecarboxylic acid -bipyridine for enhancement of the efficiency of 3-nitrotyrosine biomarker for early diagnosis of liver cirrhosis with minimal hepatic encephalopathy.
Topics: Adult; Biomarkers; Early Diagnosis; Equipment Design; Equipment Failure Analysis; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Luminescent Measurements; Male; Middle Aged; Optical Devices; Platinum; Pyrazinamide; Reproducibility of Results; Sensitivity and Specificity; Transducers; Tyrosine | 2016 |
Thrombus Aspirated from Patients with ST-Elevation Myocardial Infarction: Association between 3-Nitrotyrosine and Inflammatory Markers - Insights from ARTERIA Study.
Topics: Aged; Biomarkers; C-Reactive Protein; CD40 Ligand; Coronary Thrombosis; Enzyme-Linked Immunosorbent Assay; Female; Hemoglobins; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Oxidative Stress; Percutaneous Coronary Intervention; Tyrosine; Vascular Cell Adhesion Molecule-1 | 2016 |
Direct detection of nitrotyrosine-containing proteins using an aniline-based oxidative coupling strategy.
Topics: Aniline Compounds; Dithionite; Fluorescence; Fluorescent Dyes; Molecular Structure; Oxidation-Reduction; Proteins; Tyrosine | 2016 |
The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Amidohydrolases; Animals; Aryldialkylphosphatase; Body Weight; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Lipid Peroxidation; Male; Metformin; Organ Size; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2016 |
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Hippocampus; Mice, Transgenic; Microelectrodes; Mitochondria; Neurotransmitter Agents; Nitric Oxide; Oxidative Phosphorylation; Oxygen Consumption; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tyrosine | 2016 |
An Immunohistochemical Study on the Role of Oxidative and Nitrosative Stress in Irradiated Skin.
Topics: Adult; Aged; Aged, 80 and over; Dinoprost; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitrosation; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Skin; Tyrosine; Young Adult | 2017 |
Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products.
Topics: Aged; Blood Glucose; Coronary Angiography; Coronary Artery Disease; Disease Progression; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Prediabetic State; Severity of Illness Index; Tyrosine | 2017 |
Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts.
Topics: Aldehydes; Blotting, Western; Case-Control Studies; Cells, Cultured; Female; Fibroblasts; Humans; Proteins; Proteome; Proteomics; Real-Time Polymerase Chain Reaction; Rett Syndrome; Tyrosine | 2016 |
Dopamine induces lipid accumulation, NADPH oxidase-related oxidative stress, and a proinflammatory status of the plasma membrane in H9c2 cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caspase 3; Cell Line; Cell Membrane; Cell Survival; Dopamine; Dopamine Agents; Flow Cytometry; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Inflammation; Lipid Metabolism; Microscopy, Electron; Microscopy, Fluorescence; Myoblasts, Cardiac; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Nuclear Proteins; Oxidative Stress; Peroxidase; Rats; Reactive Oxygen Species; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; Tyrosine | 2016 |
Left ventricular pressure-volume measurements and myocardial gene expression profile in type 2 diabetic Goto-Kakizaki rats.
Topics: Animals; Apoptosis; Atrial Natriuretic Factor; Blood Glucose; C-Reactive Protein; Connective Tissue Growth Factor; Diabetes Mellitus, Type 2; Down-Regulation; Echocardiography; Electrocardiography; Fibrosis; Glucose Tolerance Test; Glycosuria; Hypertrophy, Left Ventricular; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Male; Myocardium; Natriuretic Peptide, Brain; Oxidative Stress; Peptide Fragments; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Troponin T; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2016 |
Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice.
Topics: Abietanes; Aging; Aldehydes; Analysis of Variance; Animals; Cinnamates; Conditioning, Classical; Conditioning, Operant; Depsides; Dose-Response Relationship, Drug; Electroshock; Maze Learning; Mice; Mice, Mutant Strains; Oxidative Stress; Recognition, Psychology; Reinforcement, Psychology; Rosmarinic Acid; Rosmarinus; Triglycerides; Tyrosine | 2016 |
Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.
Topics: Actin Cytoskeleton; Actins; Animals; Cells, Cultured; Humans; Hypoxia; Membrane Glycoproteins; Middle Cerebral Artery; Muscle, Smooth, Vascular; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Reperfusion Injury; RNA, Small Interfering; Tyrosine; Up-Regulation | 2016 |
Minimally Modified LDL-Induced Impairment of Endothelium-Dependent Relaxation in Small Mesenteric Arteries of Mice.
Topics: Animals; Biological Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression Regulation; In Vitro Techniques; Intermediate-Conductance Calcium-Activated Potassium Channels; Lipoproteins, LDL; Male; Mesenteric Arteries; Mice, Inbred ICR; Nitric Oxide; Small-Conductance Calcium-Activated Potassium Channels; Superoxides; Time Factors; Tyrosine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2016 |
Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams.
Topics: A549 Cells; DNA; DNA Breaks, Double-Stranded; Dose-Response Relationship, Radiation; Histones; Humans; Lasers; Nitrogen Oxides; Phosphorylation; Protons; Relative Biological Effectiveness; Tyrosine | 2016 |
Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia.
Topics: Acetophenones; Allopurinol; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antioxidants; Body Weight; Carbon Dioxide; Carotid Sinus; Catecholamines; Chemoreceptor Cells; Free Radical Scavengers; Heart Rate; Hypoxia; Losartan; Male; Oxidative Stress; Oxygen Consumption; Plethysmography; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Regression Analysis; Respiration; Tidal Volume; Time Factors; Tyrosine | 2016 |
Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort.
Topics: Biomarkers; DNA Methylation; Female; Humans; Leptin; Maternal Exposure; Oxidative Stress; Particulate Matter; Placenta; Pregnancy; Pregnancy Trimester, Second; Promoter Regions, Genetic; Tyrosine | 2017 |
Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease.
Topics: Amides; Animals; Anti-Inflammatory Agents; Apoptosis; Body Weight; Colitis; Cyclooxygenase 2; Cytokines; Dicarboxylic Acids; Dinitrofluorobenzene; Ethanolamines; Extracellular Signal-Regulated MAP Kinases; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Mice; NF-kappa B; P-Selectin; Palmitic Acids; Peroxidase; Phosphorylation; PPAR alpha; PPAR gamma; Receptor, Cannabinoid, CB2; Signal Transduction; Tyrosine | 2016 |
Neuroprotective effects of methane-rich saline on experimental acute carbon monoxide toxicity.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Carbon Monoxide Poisoning; Carboxyhemoglobin; Cell Count; Cytokines; Deoxyguanosine; Disease Models, Animal; Hippocampus; Male; Malondialdehyde; Methane; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Superoxide Dismutase; Time Factors; Tyrosine | 2016 |
Response of the Nitric Oxide System to Hypobaric Hypoxia in the Aged Striatum.
Topics: Aging; Animals; Atmospheric Pressure; Corpus Striatum; Hypoxia, Brain; Immunohistochemistry; Male; Models, Neurological; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; RNA, Messenger; Tyrosine | 2017 |
Atypical microglial response to biodiesel exhaust in healthy and hypertensive rats.
Topics: Aconitate Hydratase; Animals; Antioxidants; Biofuels; Calcium-Binding Proteins; Chemokine CX3CL1; Cytokines; Dose-Response Relationship, Drug; Hypertension; Male; Microfilament Proteins; Microglia; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase; Vehicle Emissions | 2017 |
Mitigating effect of EUK-207 on radiation-induced cognitive impairments.
Topics: Analysis of Variance; Animals; Cognition Disorders; Conditioning, Psychological; Dose-Response Relationship, Radiation; Fear; Male; Maze Learning; Mice; Mice, Inbred C57BL; Organometallic Compounds; Radiation Injuries, Experimental; Superoxide Dismutase; Tyrosine | 2017 |
Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Cells, Cultured; Cisplatin; Cochlea; Disease Models, Animal; Down-Regulation; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; LIM Domain Proteins; Manganese Compounds; Membrane Proteins; Mice; Mice, Inbred CBA; Peroxynitrous Acid; Serpins; Signal Transduction; Tyrosine | 2016 |
Effects of Chinese Medicinal Compound Jinmaitong on the Expression of Nitrotyrosine andNerve Growth Factor in the Dorsal Root Ganglia of Diabetic Rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Ganglia, Spinal; Immunohistochemistry; Nerve Growth Factor; Pain Threshold; Random Allocation; Rats; Tyrosine | 2016 |
Antidepressant-like effect of pramipexole in an inflammatory model of depression.
Topics: Animals; Benzothiazoles; Brain; Depression; Disease Models, Animal; Dopamine Agonists; Female; Glial Fibrillary Acidic Protein; Illness Behavior; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Locomotion; Malondialdehyde; Mice; Pramipexole; Swimming; Time Factors; Tyrosine | 2017 |
Regression of fibrosis/cirrhosis by Glycine propionyl-l-carnitine treatment in d-Galactosamine induced chronic liver damage.
Topics: Actins; Animals; Body Weight; Carnitine; Chronic Disease; Collagen Type I; Galactosamine; Gene Expression Regulation; Glycine; Hydroxyproline; In Situ Nick-End Labeling; Interleukin-6; Liver; Liver Cirrhosis; Male; Oxidative Stress; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways.
Topics: Animals; Blotting, Western; Chronic Disease; Collagen; Galactosamine; Genistein; Hepatic Stellate Cells; In Situ Nick-End Labeling; Liver; Liver Cirrhosis; Male; Rats, Wistar; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Tyrosine | 2017 |
1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia.
Topics: Animals; Annexin A5; Apoptosis; Cells, Cultured; Cognition Disorders; Disease Models, Animal; Gene Expression Regulation; Hypoxia; Imines; Lipid Peroxidation; Malondialdehyde; Maze Learning; Microglia; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase Type II; Oxygen; Rats; Rats, Sprague-Dawley; Tyrosine | 2017 |
Doxorubicin inhibits muscle inflammation after eccentric exercise.
Topics: Animals; Anti-Inflammatory Agents; Doxorubicin; Interleukin-10; Macrophages; Male; Muscle, Skeletal; Physical Conditioning, Animal; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
The role of spironolactone on myocardial oxidative stress in rat model of streptozotocin-induced diabetes.
Topics: Aldosterone; Animals; Blood Pressure; Catalase; Cytochrome P-450 CYP11B2; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Nitrites; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Spironolactone; Streptozocin; Superoxide Dismutase; Time Factors; Tyrosine; Vitamin E | 2017 |
H2S Attenuates LPS-Induced Acute Lung Injury by Reducing Oxidative/Nitrative Stress and Inflammation.
Topics: Acute Lung Injury; Animals; Antioxidants; Endotoxemia; Hydrogen Peroxide; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Malondialdehyde; Mice, Inbred ICR; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosation; Organothiophosphorus Compounds; Oxidative Stress; Tyrosine | 2016 |
Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia.
Topics: Animals; Brain; Corpus Striatum; Dizocilpine Maleate; Glial Fibrillary Acidic Protein; Glycine; Hyperglycinemia, Nonketotic; I-kappa B Proteins; Injections, Intraventricular; MAP Kinase Signaling System; Neurons; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats, Wistar; Synaptophysin; tau Proteins; Tyrosine | 2018 |
Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.
Topics: AMP-Activated Protein Kinases; Angiogenesis Inducing Agents; Animals; Antigens, CD; Cadherins; Cell Proliferation; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Genotype; In Vitro Techniques; Membrane Potential, Mitochondrial; Mice, Transgenic; Mitochondria; NADPH Oxidases; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Phenotype; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2017 |
Extracellular Signal-Regulated Kinase/Nuclear Factor-Erythroid2-like2/Heme Oxygenase-1 Pathway-Mediated Mitophagy Alleviates Traumatic Brain Injury-Induced Intestinal Mucosa Damage and Epithelial Barrier Dysfunction.
Topics: Aldehydes; Animals; Brain Injuries, Traumatic; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Heme Oxygenase-1; Intestinal Mucosa; Male; Mitophagy; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2017 |
Specific enrichment of a targeted nitrotyrosine-containing peptide from complex matrices and relative quantification for liquid chromatography-mass spectrometry analysis.
Topics: Acetylation; Angiotensin II; Chromatography, Liquid; Humans; Hydrolysis; Mass Spectrometry; Nitro Compounds; Peptides; Serum Albumin, Bovine; Tyrosine | 2017 |
Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production.
Topics: Animals; Cerebral Arteries; Cerebral Cortex; Cyclooxygenase 2; Inflammation; Lipopolysaccharides; Magnetic Resonance Angiography; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Prostaglandins; Proto-Oncogene Proteins c-fos; Tyrosine | 2017 |
Metallothionein protects against isoniazid-induced liver injury through the inhibition of CYP2E1-dependent oxidative and nitrosative impairment in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Isoniazid; Lipid Peroxidation; Liver; Male; Metallothionein; Mice, Inbred C57BL; Mice, Mutant Strains; Oxidative Stress; Tyrosine | 2017 |
Development of a new HPLC-based method for 3-nitrotyrosine quantification in different biological matrices.
Topics: Animals; Biomarkers; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Linear Models; Mice; Reproducibility of Results; Tyrosine | 2017 |
An immunohistochemical study of nitrotyrosine expression in pancreatic islets of cases with increasing duration of type 1 diabetes and without diabetes.
Topics: Adolescent; Adult; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Immunohistochemistry; Islets of Langerhans; Male; Tyrosine; Young Adult | 2017 |
The transition from day-to-night activity is a risk factor for the development of CNS oxygen toxicity in the diurnal fat sand rat (Psammomys obesus).
Topics: Animals; Antioxidants; Biological Clocks; Central Nervous System Diseases; Circadian Rhythm; Gerbillinae; Hyperbaric Oxygenation; Male; Melatonin; Nitric Oxide Synthase Type I; Oxygen; Photoperiod; Tyrosine | 2017 |
Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation.
Topics: Animals; Aorta; Arteriovenous Shunt, Surgical; Gene Expression Regulation; Heme Oxygenase-1; Hydrogen Peroxide; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Membrane Proteins; Mice, Inbred C57BL; NADPH Oxidase 2; Neointima; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Time Factors; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Patency; Vena Cava, Inferior | 2017 |
Effect of human umbilical cord blood mesenchymal stem cells administered by intravenous or intravitreal routes on cryo-induced retinal injury.
Topics: Administration, Intravenous; Animals; Caspase 3; Cell Differentiation; Cells, Cultured; Fibroblast Growth Factor 2; Freezing; Fundus Oculi; Humans; Intravitreal Injections; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Optic Nerve Diseases; Retina; Tyrosine | 2017 |
The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Differentiation; Crotonates; Forkhead Transcription Factors; Heme Oxygenase-1; Humans; Hydroxybutyrates; Inflammation; Isoxazoles; Jurkat Cells; Leflunomide; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitriles; Oxidative Stress; Signal Transduction; Spleen; Th17 Cells; Toluidines; Tyrosine | 2017 |
Topics: Adult; Animals; Calcium Channels, L-Type; Calcium Signaling; Calcium-Binding Proteins; Cardiomyopathies; Case-Control Studies; Disease Models, Animal; Female; Genetic Predisposition to Disease; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Phenotype; Potassium Channels, Inwardly Rectifying; Reactive Nitrogen Species; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure | 2017 |
MiR-181c restrains nitration stress of endothelial cells in diabetic db/db mice through inhibiting the expression of FoxO1.
Topics: 3' Untranslated Regions; Animals; Aorta, Thoracic; Blotting, Western; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelial Cells; Endothelium, Vascular; Forkhead Box Protein O1; Gene Expression Regulation; Glucose; Male; Mice, Inbred ICR; MicroRNAs; Nitric Oxide Synthase Type II; Nitrosation; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tyrosine; Vasodilation | 2017 |
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arterial Pressure; Cyclooxygenase 2; Epoprostenol; Gene Expression Regulation, Enzymologic; Heart Rate; Hypotension; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Ribosomal Protein S6; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Apoptosis; Cell Line; Cell Proliferation; Down-Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Myelin Basic Protein; Oligodendroglia; Oxidative Stress; Oxygen; Rats; RNA Interference; RNA, Small Interfering; SOX9 Transcription Factor; Tyrosine; Up-Regulation | 2017 |
Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart.
Topics: Animals; Endotoxins; Ischemic Preconditioning, Myocardial; Lactate Dehydrogenases; Lipopolysaccharides; Male; Myocardial Ischemia; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxynitrous Acid; Rats; STAT3 Transcription Factor; Tyrosine | 2017 |
Oxidative modifications of blood serum proteins in myasthenia gravis.
Topics: Adult; Advanced Oxidation Protein Products; Aged; Aged, 80 and over; Autoantibodies; Benzothiazoles; Blood Proteins; Disease Progression; Female; Glycophorins; Humans; Kynurenine; Male; Middle Aged; Myasthenia Gravis; Oxidative Stress; Protein Carbonylation; Receptors, Cholinergic; Sulfonic Acids; Thymectomy; Tyrosine | 2017 |
Cannabinoid CB2 receptors are involved in the protection of RAW264.7 macrophages against the oxidative stress: an in vitro study.
Topics: Animals; bcl-2-Associated X Protein; Cannabinoids; Hydrogen Peroxide; Indoles; Macrophages; Mice; Nitric Oxide Synthase Type II; Oxidative Stress; Piperidines; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; RAW 264.7 Cells; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Superoxide Dismutase-1; Tyrosine | 2017 |
Prolactin/androgen-inducible carboxypeptidase-D increases with nitrotyrosine and Ki67 for breast cancer progression in vivo, and upregulates progression markers VEGF-C and Runx2 in vitro.
Topics: Androgens; Breast Neoplasms; Carboxypeptidases; Core Binding Factor Alpha 1 Subunit; Cullin Proteins; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; MCF-7 Cells; Nitric Oxide; Prolactin; Receptors, Androgen; Receptors, Prolactin; Tyrosine; Vascular Endothelial Growth Factor C | 2017 |
Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men's seminal quality.
Topics: Adolescent; Adult; Alcohol Drinking; Glutathione Peroxidase; Humans; Male; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase; Protein Carbonylation; Smoking; Sperm Motility; Spermatozoa; Superoxide Dismutase-1; Surveys and Questionnaires; Tyrosine; Young Adult | 2017 |
Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex.
Topics: Acetophenones; Afferent Pathways; Aldehydes; Animals; Antioxidants; Ascorbic Acid; Biotin; Brain Injuries; Dendrites; Dextrans; Disease Models, Animal; Electron Transport Complex IV; Epidural Space; Functional Laterality; Male; Neurons; Oxidative Stress; Rats; Somatosensory Cortex; Thalamus; Time Factors; Tyrosine | 2017 |
In focus in HCB.
Topics: Diabetes Mellitus, Type 1; Humans; Islets of Langerhans; Tyrosine | 2017 |
Hyperoxia or Therapeutic Hypothermia During Resuscitation from Non-Lethal Hemorrhagic Shock in Swine.
Topics: Animals; Blood Gas Analysis; Hemodynamics; Hyperoxia; Hypothermia, Induced; Nitric Oxide Synthase Type II; Oxidative Stress; Shock, Hemorrhagic; Swine; Tyrosine | 2017 |
Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration.
Topics: Biosensing Techniques; Fluorescent Dyes; Human Umbilical Vein Endothelial Cells; Humans; Limit of Detection; Nitric Oxide; Peptides; Peroxynitrous Acid; Tyrosine | 2017 |
Markers of oxidative/nitrative damage of plasma proteins correlated with EDSS and BDI scores in patients with secondary progressive multiple sclerosis.
Topics: Adult; Biomarkers; Blood Proteins; Depression; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Multiple Sclerosis; Oxidation-Reduction; Oxidative Stress; Tyrosine | 2017 |
A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women.
Topics: Adult; Brain-Derived Neurotrophic Factor; Cytokines; Depressive Disorder, Major; Female; HSP70 Heat-Shock Proteins; Humans; Inflammation; Lipid Peroxidation; Longitudinal Studies; Middle Aged; Oxidative Stress; Protein Carbamylation; Psychiatric Status Rating Scales; Surveys and Questionnaires; Thiobarbituric Acid Reactive Substances; Tyrosine | 2018 |
Determination of 3-nitrotyrosine in food protein suspensions.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Food; Food Analysis; Food Contamination; Proteins; Suspensions; Tyrosine | 2017 |
Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Arterial Pressure; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Hypertension; Male; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidase 4; Nitric Oxide; Oxidative Stress; Renal Artery; Sodium Nitrite; Tyrosine; Vasodilation | 2018 |
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cisplatin; Cytokines; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Inflammation Mediators; Kidney; Male; Malondialdehyde; Membrane Proteins; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphorylation; Signal Transduction; Tyrosine | 2017 |
Effect of a new formulation of micronized and ultramicronized N-palmitoylethanolamine in a tibia fracture mouse model of complex regional pain syndrome.
Topics: Animals; bcl-2-Associated X Protein; Complex Regional Pain Syndromes; Disease Models, Animal; Ethanolamines; Immunohistochemistry; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Nerve Growth Factor; Proto-Oncogene Proteins c-bcl-2; Tibia; Tibial Fractures; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury.
Topics: Animals; Blood-Brain Barrier; Brain Injuries, Traumatic; Catalase; Endothelial Cells; Hydrogen Peroxide; Intercellular Adhesion Molecule-1; Mice; Microglia; Neuroglia; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Tyrosine | 2017 |
Controlled arterial reflow after ischemia induces better outcomes in the juvenile rat brain.
Topics: Animals; Brain Ischemia; Cell Death; Cerebral Arteries; Cerebrovascular Circulation; Cyclooxygenase 2; Disease Models, Animal; Prostaglandin-E Synthases; Rats, Wistar; Reperfusion; Reperfusion Injury; Treatment Outcome; Tyrosine; Ultrasonography | 2017 |
Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats.
Topics: Animals; Blood Urea Nitrogen; Cisplatin; Coumaric Acids; Curcumin; Heme Oxygenase (Decyclizing); Kidney; Kidney Diseases; Male; Malondialdehyde; Peroxidase; Protective Agents; Rats, Wistar; RNA, Messenger; Tyrosine | 2017 |
Experimental studies on possible regulatory role of nitric oxide on the differential effects of chronic predictable and unpredictable stress on adaptive immune responses.
Topics: Adaptive Immunity; Animals; Brain; Chronic Disease; Disease Models, Animal; Hypersensitivity, Delayed; Immunity, Humoral; Immunoglobulin G; Immunosuppression Therapy; Male; Nitric Oxide; Rats; Restraint, Physical; Stress, Psychological; Tyrosine | 2017 |
Peroxynitrite Footprint in Circulating Neutrophils of Abdominal Aortic Aneurysm Patients is Lower in Statin than in Non-statin Users.
Topics: Adult; Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Biomarkers; Case-Control Studies; Female; Humans; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Male; Middle Aged; Monocytes; Neutrophils; Peroxynitrous Acid; Tyrosine | 2017 |
Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples.
Topics: Animals; Antibodies; Binding Sites; Lung; Mice; Peptides; Poly I-C; Proteomics; Tyrosine | 2017 |
Enhanced NO-dependent pulmonary vasodilation limits increased vasoconstrictor sensitivity in neonatal chronic hypoxia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Chronic Disease; Enzyme Inhibitors; Free Radical Scavengers; Hypoxia; Lung; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Tyrosine; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2017 |
Minocycline attenuates streptomycin-induced cochlear hair cell death by inhibiting protein nitration and poly (ADP-ribose) polymerase activation.
Topics: Animals; Anti-Bacterial Agents; Caspase 3; Cell Death; Cochlea; Enzyme Activation; Hair Cells, Auditory; Minocycline; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Rats, Wistar; Streptomycin; Transcription, Genetic; Tyrosine | 2017 |
Nitration of H2B histone elicits an immune response in experimental animals.
Topics: Animals; Autoantibodies; Autoantigens; Autoimmunity; Cross Reactions; Histones; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Peroxynitrous Acid; Protein Binding; Rabbits; Tyrosine | 2017 |
Genipin attenuates cisplatin-induced nephrotoxicity by counteracting oxidative stress, inflammation, and apoptosis.
Topics: Aldehydes; Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Caspase 3; Caspase 7; Cell Line, Tumor; Cisplatin; Creatinine; Cystatin C; Cytokines; Hepatitis A Virus Cellular Receptor 1; Humans; Inflammation; Iridoids; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Oxidative Stress; Poly(ADP-ribose) Polymerases; Tyrosine | 2017 |
Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Limit of Detection; Miniaturization; Oxidative Stress; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tyrosine; Video Recording | 2017 |
Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Enzymes; Fatty Acids; Fatty Liver; Hypercholesterolemia; Insulin; Liver; Male; Nitrosative Stress; Organ Size; Oxidative Stress; Pancreas; Rats, Wistar; RNA, Messenger; Triglycerides; Tyrosine | 2017 |
Importance of NADPH oxidase-mediated redox signaling in the detrimental effect of CRP on pancreatic insulin secretion.
Topics: Acetophenones; Acetylcysteine; Animals; C-Reactive Protein; Cell Line; Dose-Response Relationship, Drug; Etanercept; Gene Expression Regulation; Guanidines; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred BALB C; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Oxidation-Reduction; Proline; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Polyphenol-Rich Fraction of Parquetina nigrescens Mitigates Dichlorvos-Induced Cardiorenal Dysfunction Through Reduction in Cardiac Nitrotyrosine and Renal p38 Expressions in Wistar Rats.
Topics: Administration, Oral; Animals; Biomarkers; Cryptolepis; Dichlorvos; Dietary Supplements; Heart Ventricles; Insecticides; Kidney; Male; Nigeria; Organophosphate Poisoning; p38 Mitogen-Activated Protein Kinases; Plant Components, Aerial; Plant Extracts; Polyphenols; Protective Agents; Random Allocation; Rats, Wistar; Renal Insufficiency; Tyrosine; Ventricular Dysfunction | 2018 |
Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project.
Topics: Adult; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Biomarkers; Carotenoids; Female; Glutathione; Humans; Lipid Peroxidation; Lycopene; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Tyrosine; Uric Acid | 2017 |
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular; Male; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Phenotype; Signal Transduction; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress.
Topics: Animals; Aorta, Thoracic; Biomarkers; Endothelium, Vascular; Fatty Acids, Omega-3; Kidney Failure, Chronic; Male; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2017 |
The Anti-Inflammatory and Antioxidant Potential of Pistachios (Pistacia vera L.) In Vitro and In Vivo.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophages; Male; Mice; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nuts; Oxidative Stress; Phytotherapy; Pistacia; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Nitrosative Stress in the Rat Retina at the Onset of Streptozotocin-Induced Diabetes.
Topics: Animals; Cyclic GMP; Diabetes Mellitus, Experimental; Glial Fibrillary Acidic Protein; Immunohistochemistry; Microscopy, Fluorescence; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Protein Carbonylation; Rats; Rats, Long-Evans; Retina; Streptozocin; Tyrosine | 2017 |
Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis.
Topics: Alginates; Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Nitrosative Stress; Oligosaccharides; Oxidative Stress; Superoxides; Tyrosine | 2017 |
Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Cholesterol, Dietary; Diet; Dietary Fats; Disease Models, Animal; Endotoxins; Fatty Liver; Female; Fructose; Gastrointestinal Microbiome; Intestine, Small; Lipid Peroxidation; Lipogenesis; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Occludin; Toll-Like Receptor 4; Triglycerides; Tyrosine; Zonula Occludens-1 Protein | 2017 |
The histone deacetylase inhibitor sodium butyrate protects against noise-induced hearing loss in Guinea pigs.
Topics: Animals; Butyric Acid; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histones; Male; Tyrosine | 2017 |
Impact of tyrosine nitration at positions Tyr307 and Tyr335 on structural dynamics of Lipoprotein-associated phospholipase A
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Amino Acid Sequence; Atherosclerosis; Biomarkers; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Nitrosation; Platelet Activating Factor; Principal Component Analysis; Substrate Specificity; Thermodynamics; Tyrosine | 2018 |
Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet.
Topics: Animals; Arginine; Atherosclerosis; Betaine; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Fatty Liver; Guinea Pigs; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Nitric Oxide; Tyrosine | 2018 |
Relationship of particulate matter and ozone with 3-nitrotyrosine in the atmosphere.
Topics: Air Pollutants; Atmosphere; Humans; Humidity; Nitrogen Dioxide; Ozone; Particulate Matter; Sulfur Dioxide; Temperature; Tyrosine | 2018 |
Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice.
Topics: Aldehydes; Animals; Antioxidants; Ascomycota; Body Weight; Catalase; Dexamethasone; Extracellular Space; Glutathione; Male; Malondialdehyde; Mice, Inbred ICR; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Nitric Oxide Synthase Type II; Organ Size; Poly(ADP-ribose) Polymerases; Polysaccharides; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tyrosine | 2018 |
Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation.
Topics: Acute Kidney Injury; Allopurinol; Animals; Antioxidants; Bothrops; Crotalid Venoms; Glomerular Filtration Rate; Glutathione; Hemolysis; Kidney; Lactic Acid; Male; Oxidative Stress; Rats, Wistar; Tyrosine | 2017 |
Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice.
Topics: Aldehydes; Animals; Apoptosis; Capillary Permeability; Cardiomyopathies; Carrier Proteins; Caspase 3; Disease Models, Animal; Echocardiography; Female; Heart; Heme Oxygenase-1; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Oxidative Stress; Repressor Proteins; Sepsis; Survivin; Thioredoxins; Tyrosine | 2017 |
Nitration of tyrosine and its effect on DNA hybridization.
Topics: Biosensing Techniques; DNA, Single-Stranded; Electrochemistry; Nitro Compounds; Nucleic Acid Hybridization; Oligonucleotides; Oxidation-Reduction; Tyrosine | 2018 |
Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic; CD3 Complex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutaryl-CoA Dehydrogenase; Inflammation; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Quinolinic Acid; S100 Calcium Binding Protein beta Subunit; Statistics, Nonparametric; Time Factors; Tyrosine | 2018 |
Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins.
Topics: Adult; Antioxidants; Blood Platelets; Blood Proteins; Free Radical Scavengers; Humans; Lipid Peroxidation; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Phenelzine; Plasma; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Tyrosine; Young Adult | 2018 |
Continuous 900-megahertz electromagnetic field applied in middle and late-adolescence causes qualitative and quantitative changes in the ovarian morphology, tissue and blood biochemistry of the rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Catalase; Electromagnetic Fields; Female; Granulosa Cells; Guanine; Humidity; Leukocytes; Mitosis; Organ Size; Ovary; Oxidative Stress; Rats; Rats, Sprague-Dawley; Temperature; Theca Cells; Time Factors; Tyrosine | 2018 |
Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke.
Topics: Animals; Antioxidants; Caspase 3; Cell Survival; Cells, Cultured; Disease Models, Animal; Humans; Ischemia; Mice; Mice, Inbred C57BL; Microglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Reactive Oxygen Species; Stroke; Tyrosine | 2018 |
Proteomic analysis of peroxynitrite-induced protein nitration in isolated beef heart mitochondria.
Topics: Animals; Cattle; In Vitro Techniques; Mitochondria, Heart; Mitochondrial Proteins; Nitrogen; Peroxynitrous Acid; Proteomics; Tyrosine | 2018 |
Important role of endothelium-dependent hyperpolarization in the pulmonary microcirculation in male mice: implications for hypoxia-induced pulmonary hypertension.
Topics: Animals; Biological Factors; Disease Models, Animal; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Male; Membrane Potentials; Mice, Inbred C57BL; Microcirculation; Nitric Oxide; Pulmonary Artery; Pulmonary Circulation; Signal Transduction; Tyrosine; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2018 |
Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure.
Topics: Animals; Corpus Striatum; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Imidazoles; Male; Neurotoxicity Syndromes; Oxidative Stress; Parkinson Disease, Secondary; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine | 2018 |
Curcumin exerts a protective effect against premature ovarian failure in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Mullerian Hormone; Apoptosis; Curcumin; Cyclin-Dependent Kinase Inhibitor p16; Deoxyguanosine; Disease Models, Animal; Female; Galactose; Gonads; Hypothalamo-Hypophyseal System; Mice, Inbred C57BL; Ovary; Oxidative Stress; Primary Ovarian Insufficiency; Protective Agents; RNA, Messenger; Tyrosine | 2018 |
Panton-Valentine Leukocidin Colocalizes with Retinal Ganglion and Amacrine Cells and Activates Glial Reactions and Microglial Apoptosis.
Topics: Amacrine Cells; Animals; Apoptosis; Bacterial Toxins; Biological Transport; Exotoxins; Gene Expression Regulation; Interleukin-6; Leukocidins; Microglia; Rabbits; Retinal Ganglion Cells; Tyrosine | 2018 |
Lead inhalation and hepatic damage: Morphological and functional evaluation in mice.
Topics: Administration, Inhalation; Air Pollutants; Aldehydes; Animals; Atmosphere Exposure Chambers; Biomarkers; Hepatic Insufficiency; Immunohistochemistry; Lead; Lead Poisoning; Leukocytes, Mononuclear; Liver; Male; Mice; Neutrophil Infiltration; Nitrosative Stress; Oxidative Stress; Random Allocation; Tissue Distribution; Toxicity Tests, Acute; Toxicity Tests, Chronic; Toxicokinetics; Tyrosine | 2018 |
Carnosine protects pancreatic beta cells and islets against oxidative stress damage.
Topics: Animals; Apoptosis; Biomarkers; Carnosine; Cell Line; Cell Proliferation; Cell Shape; Cell Survival; Cytoprotection; Gene Expression Regulation; Glucose; Humans; Hydrogen Peroxide; Insulin Secretion; Insulin-Secreting Cells; Mice; Nitrous Oxide; Oxidative Stress; Protective Agents; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Transcription Factor RelA; Tyrosine | 2018 |
The reduction in circulating levels of estrogen and progesterone in women with preeclampsia.
Topics: 2-Methoxyestradiol; Adult; Biomarkers; Case-Control Studies; Culture Media, Conditioned; Down-Regulation; Estradiol; Female; Fetal Growth Retardation; Humans; Hydrogen Peroxide; Placenta; Pre-Eclampsia; Pregnancy; Progesterone; Receptors, Estrogen; Receptors, Progesterone; Severity of Illness Index; Tissue Culture Techniques; Tyrosine; Young Adult | 2018 |
A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells.
Topics: Adult; Aged; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Luminescent Measurements; Male; Middle Aged; Oxidative Stress; Tyrosine | 2018 |
Nitric oxide synthase and oxidative-nitrosative stress play a key role in placental infection by Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Chorionic Gonadotropin; Female; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrosative Stress; Oxidative Stress; Placenta; Pregnancy; Reactive Oxygen Species; Trophoblasts; Trypanosoma cruzi; Tyrosine | 2018 |
Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress.
Topics: Amidohydrolases; Animals; Corticosterone; Cytokines; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Inflammation Mediators; Male; Nitrates; Nitric Oxide; Nitrites; Nitrosative Stress; Piperidines; Pyridines; Rats, Wistar; Restraint, Physical; Signal Transduction; Stress, Psychological; Time Factors; Tyrosine | 2018 |
Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis.
Topics: Animals; Aorta; Atherosclerosis; Blood Urea Nitrogen; Creatinine; Diet, Fat-Restricted; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Disease Progression; Kidney Failure, Chronic; Kidney Function Tests; Lipids; Lipoproteins; Macrophages; Male; Mice; Mice, Knockout; Muscle Proteins; Nephrectomy; Oxidants; Oxidative Stress; Parathyroid Hormone; Peroxidase; Receptors, LDL; Tyrosine; Vasodilation | 2018 |
Lipopolysaccharide Induces Subacute Cerebral Microhemorrhages with Involvement of Nitric Oxide Synthase in Rats.
Topics: Animals; Brain; Capillary Permeability; Cerebral Hemorrhage; Disease Models, Animal; Inflammation; Isoenzymes; Lipopolysaccharides; Male; Microglia; Neuroimmunomodulation; Neurons; Nitric Oxide Synthase; Rats, Sprague-Dawley; Tyrosine | 2018 |
Identification of Tyrosine and Nitrotyrosine with a Mixed-Mode Solid-Phase Extraction Cleanup Followed by Liquid Chromatography-Electrospray Time-of-Flight Mass Spectrometry in Plants.
Topics: Chromatography, Liquid; Plants; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2018 |
Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Collagen Type I; Estrogens; Female; Glutathione; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; Ovariectomy; Physical Conditioning, Animal; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-2; Tyrosine; Ventricular Remodeling | 2018 |
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; DNA Damage; Dopamine Plasma Membrane Transport Proteins; Inflammation; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrosative Stress; Oxazoles; Oxidative Stress; Parkinson Disease; Poly Adenosine Diphosphate Ribose; Transcription Factor RelA; Tyrosine; Tyrosine 3-Monooxygenase | 2018 |
DNA Methylation-a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy.
Topics: Animals; APOBEC Deaminases; Base Pair Mismatch; Base Sequence; Cytosine; Diabetic Retinopathy; DNA Methylation; DNA, Mitochondrial; Endothelial Cells; Humans; Mice, Inbred C57BL; Nucleic Acid Conformation; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2019 |
Simultaneous analysis of multiple urinary biomarkers for the evaluation of oxidative stress by automated online in-tube solid-phase microextraction coupled with negative/positive ion-switching mode liquid chromatography-tandem mass spectrometry.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Chromatography, Liquid; Deoxyguanosine; Dinoprost; Humans; Limit of Detection; Male; Oxidative Stress; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2018 |
The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney.
Topics: Aged; Animals; Antioxidants; Female; Gene Expression Regulation, Enzymologic; Glucuronidase; Humans; Kidney; Klotho Proteins; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Oxidative Stress; Tumor Suppressor Protein p53; Tyrosine | 2018 |
Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics.
Topics: Animals; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Mechanistic Target of Rapamycin Complex 1; Mitochondria; Mitochondrial Dynamics; Mitophagy; Proteolysis; Rats; Reactive Oxygen Species; Signal Transduction; Tuberous Sclerosis Complex 2 Protein; Tyrosine; Ubiquitination; Up-Regulation | 2018 |
Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment.
Topics: Adolescent; Antioxidants; Biomarkers; Child; Child, Preschool; Fatigue; Female; Humans; Longitudinal Studies; Male; Nitrosative Stress; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Tyrosine | 2018 |
Targeting Phosphodiesterase-5 by Vardenafil Improves Vascular Graft Function.
Topics: Actins; Animals; Aorta, Thoracic; Cold Ischemia; Cyclic GMP; Cytoprotection; DNA Damage; Intercellular Adhesion Molecule-1; Male; Nitrosative Stress; Phosphodiesterase 5 Inhibitors; Platelet Endothelial Cell Adhesion Molecule-1; Rats, Inbred Lew; Reperfusion Injury; Signal Transduction; Tissue and Organ Harvesting; Tyrosine; Vardenafil Dihydrochloride; Vascular Cell Adhesion Molecule-1; Vascular System Injuries; Vasodilator Agents; Warm Ischemia | 2018 |
Tauroursodeoxycholic acid attenuates gentamicin-induced cochlear hair cell death in vitro.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Biomarkers; Cell Line; Cell Survival; Cochlea; Endoplasmic Reticulum Stress; Gene Expression Regulation; Gentamicins; Hair Cells, Auditory; Hearing Loss, Sensorineural; Humans; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Nitric Oxide Synthase Type II; Protective Agents; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Taurochenodeoxycholic Acid; Tissue Culture Techniques; Tyrosine | 2018 |
Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Arterial Pressure; Biomarkers; Catalase; Disease Models, Animal; Epinephrine; Ethanol; Hypertension; Lipid Peroxidation; Male; NADPH Oxidases; Nebivolol; Nitric Oxide; Norepinephrine; Oxidative Stress; Rats, Wistar; Renin-Angiotensin System; Superoxide Dismutase; Sympathetic Nervous System; Tyrosine | 2018 |
Adenoma of colorectal laterally spreading tumor nongranular type with biological phenotypic features similar to cancer.
Topics: Adenoma; Carcinogenesis; Cohort Studies; Colorectal Neoplasms; Fibrosis; Humans; Intestinal Mucosa; Ki-67 Antigen; Microvessels; Mucins; Neoplasm Invasiveness; Nitric Oxide Synthase Type II; Phenotype; Retrospective Studies; Tumor Suppressor Protein p53; Tyrosine | 2018 |
Tyrosine nitration of cytosolic peroxidase is probably triggered as a long distance signaling response in sunflower seedling cotyledons subjected to salt stress.
Topics: Cotyledon; Helianthus; Osmotic Pressure; Seedlings; Signal Transduction; Sodium Chloride; Stress, Physiological; Tyrosine | 2018 |
Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia.
Topics: Adrenal Glands; Animals; Carotid Body; Hypoxia; Immunohistochemistry; Male; Nitrosative Stress; Oxidative Stress; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2018 |
Computational Prediction and Analysis for Tyrosine Post-Translational Modifications via Elastic Net.
Topics: Amino Acid Sequence; Animals; Humans; Models, Biological; Models, Chemical; Phosphorylation; Protein Processing, Post-Translational; Proteins; Support Vector Machine; Tyrosine | 2018 |
Nitration of Tyrosine in the Mucin Glycoprotein of Edible Bird's Nest Changes Its Color from White to Red.
Topics: Animals; Birds; Color; Enzyme-Linked Immunosorbent Assay; Kinetics; Mucins; Tyrosine | 2018 |
High sucrose low copper diet in pregnant diabetic rats induces transient oxidative stress, hypoxia, and apoptosis in the offspring's liver.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Catalase; Cell Proliferation; Copper; Diabetes Mellitus, Experimental; Diet; Female; Hypoxia; Liver; Malondialdehyde; NF-kappa B; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sucrose; Superoxide Dismutase; Tyrosine; Weight Gain | 2018 |
Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide.
Topics: Aging; Animals; Chemokine CCL2; Endoplasmic Reticulum Stress; Fibrosis; Heart; Hydrogen Sulfide; Hydroxyproline; Interleukin-6; Male; Malondialdehyde; Myocardium; Physical Conditioning, Animal; Rats; Sulfides; Tyrosine | 2018 |
Inducible nitric oxide synthase-mediated injury in a mouse model of acute salivary gland dysfunction.
Topics: Acinar Cells; Animals; Calcium; Calcium Signaling; Enzyme Inhibitors; Female; Guanidines; Immunity, Innate; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitrosative Stress; Peroxynitrous Acid; Poly I-C; Saliva; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Submandibular Gland; Submandibular Gland Diseases; Tyrosine; Up-Regulation | 2018 |
p47phox-Dependent Reactive Oxygen Species Stimulate Nuclear Translocation of the FoxO1 Transcription Factor During Metabolic Inhibition in Cardiomyoblasts.
Topics: Animals; Cell Line; Cell Nucleus; Culture Media; Cytosol; Microscopy, Fluorescence; Myocytes, Cardiac; NADPH Oxidases; Nerve Tissue Proteins; Rats; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Tyrosine | 2018 |
Oxidative Stress Suppresses Cellular Autophagy in Corneal Epithelium.
Topics: Animals; Autophagy; Blotting, Western; Catalase; Cell Survival; Epithelium, Corneal; Glutathione Transferase; Humans; Hydrogen Peroxide; In Situ Nick-End Labeling; Male; NADPH Oxidase 4; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2018 |
Level of NO/nitrite and 3-nitrotyrosine in seminal plasma of infertile men: Correlation with sperm number, motility and morphology.
Topics: Adult; Antioxidants; Humans; Infertility, Male; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Semen; Sperm Count; Sperm Motility; Tyrosine | 2018 |
NTyroSite: Computational Identification of Protein Nitrotyrosine Sites Using Sequence Evolutionary Features.
Topics: Area Under Curve; Computational Biology; Computer Simulation; Protein Processing, Post-Translational; Proteins; ROC Curve; Software; Tyrosine | 2018 |
A comparative clinical study on the generation of nitrosative stress in cataractous lenses of smokers and non-smoker tobacco patients.
Topics: Cataract; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lens, Crystalline; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosative Stress; Non-Smokers; Smokers; Smoking; Tyrosine | 2019 |
Regulation of aldose reductase activity by tubulin and phenolic acid derivates.
Topics: Aldehyde Reductase; Animals; Brain; Cells, Cultured; Chlorocebus aethiops; COS Cells; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hydroxybenzoates; Oxidation-Reduction; Protein Binding; Rats; Recombinant Proteins; Tubulin; Tyrosine | 2018 |
Inhibition of GSK-3β on Behavioral Changes and Oxidative Stress in an Animal Model of Mania.
Topics: Aldehydes; Animals; Antioxidants; Behavior, Animal; Bipolar Disorder; Catalase; Dinoprost; Disease Models, Animal; Glutathione Peroxidase; Glycogen Synthase Kinase 3 beta; Lipid Peroxidation; Male; Motor Activity; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Submitochondrial Particles; Superoxide Dismutase; Superoxides; Thiazoles; Tyrosine; Urea | 2019 |
Chronic administration of quetiapine attenuates the phencyclidine-induced recognition memory impairment and hippocampal oxidative stress in rats.
Topics: Animals; Antipsychotic Agents; Female; Hippocampus; Oxidative Stress; Phencyclidine; Quetiapine Fumarate; Rats, Sprague-Dawley; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Tyrosine | 2018 |
Simultaneous determination of malondialdehyde and 3-nitrotyrosine in cultured human hepatoma cells by liquid chromatography-mass spectrometry.
Topics: Chromatography, Liquid; Hep G2 Cells; Humans; Limit of Detection; Liver Neoplasms; Malondialdehyde; Oxidative Stress; Reproducibility of Results; Tandem Mass Spectrometry; Tyrosine | 2018 |
Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation.
Topics: Amino Acids, Branched-Chain; Animals; Antioxidants; Aorta; E-Selectin; Endothelial Cells; Glucose; Humans; Inflammation; Intercellular Adhesion Molecule-1; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria; NF-kappa B; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Tyrosine; Vasoconstrictor Agents | 2018 |
Protective effect of magnesium acetyltaurate and taurine against NMDA-induced retinal damage involves reduced nitrosative stress.
Topics: Animals; Apoptosis; Drug Administration Schedule; Gene Expression Regulation; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrosative Stress; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Signal Transduction; Taurine; Tyrosine | 2018 |
Creatine Protects Against Cytosolic Calcium Dysregulation, Mitochondrial Depolarization and Increase of Reactive Oxygen Species Production in Rotenone-Induced Cell Death of Cerebellar Granule Neurons.
Topics: Animals; Animals, Newborn; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Creatine; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Electron Transport Complex I; Glutathione; Insecticides; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Rats; Reactive Oxygen Species; Rotenone; Tyrosine | 2018 |
Development and Characterization of Monoclonal Antibodies Against Nitro-
Topics: Animals; Antibodies, Monoclonal; Apolipoprotein A-I; Atherosclerosis; Early Diagnosis; Humans; Hybridomas; Lipoproteins, HDL; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Tyrosine | 2018 |
Evaluating Iodide Recycling Inhibition as a Novel Molecular Initiating Event for Thyroid Axis Disruption in Amphibians.
Topics: Animals; Iodide Peroxidase; Iodides; Larva; Metamorphosis, Biological; Monoiodotyrosine; RNA, Messenger; Symporters; Thyroid Gland; Thyroid Hormones; Tyrosine; Xenopus laevis | 2018 |
Dysregulated enzymatic antioxidant network in peripheral neutrophils and monocytes in children with autism.
Topics: Antioxidants; Autistic Disorder; Child; Child, Preschool; Correlation of Data; Cross-Sectional Studies; Female; Flow Cytometry; Glutathione Peroxidase; Glutathione Reductase; Humans; Male; Monocytes; Neutrophils; Psychiatric Status Rating Scales; Superoxide Dismutase; Tyrosine | 2019 |
Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium.
Topics: Animals; Dose-Response Relationship, Drug; Heart; Magnesium; Male; Myocardial Infarction; Myocardium; Nerve Growth Factor; Norepinephrine; Proton Pump Inhibitors; Rats; Rats, Wistar; Signal Transduction; Superoxides; Sympathetic Nervous System; Tyrosine; Ventricular Remodeling | 2018 |
Enhanced ability of plasma-activated lactated Ringer's solution to induce A549 cell injury.
Topics: A549 Cells; Antineoplastic Agents; Catalase; Cell Survival; Culture Media; Humans; Hydrogen Peroxide; Keratinocytes; Lactic Acid; Membrane Potential, Mitochondrial; Mitochondria; Nitrites; Plasma Gases; Ringer's Lactate; Signal Transduction; Tyrosine | 2018 |
Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; CA1 Region, Hippocampal; Cytokines; Disease Models, Animal; Encephalitis; Humans; Lithium; Mice, Transgenic; Mutation; Plaque, Amyloid; Rats; Tyrosine | 2018 |
Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress.
Topics: Adult; Antioxidants; Cross-Over Studies; Dinoprost; Exercise Test; Humans; Inhalation Exposure; Isoprostanes; Lipid Peroxides; Oxidative Stress; Particulate Matter; Peroxidase; Physical Exertion; Protein Carbonylation; Random Allocation; Smoke; Tyrosine; Uric Acid; Wildfires; Wood; Young Adult | 2018 |
Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion.
Topics: Animals; Anthraquinones; Apoptosis; Brain; Brain Ischemia; Caspase 3; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitrosation; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Tyrosine | 2018 |
IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.
Topics: Animals; Brain Injuries; Brain Ischemia; Cytokines; Disease Models, Animal; Inflammation; Interleukin-10; Interleukin-33; Interleukin-4; Lung; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Stroke; Th1 Cells; Th2 Cells; Treatment Outcome; Tyrosine | 2018 |
Attenuation of Remifentanil-Induced Hyperalgesia by Betulinic Acid Associates with Inhibiting Oxidative Stress and Inflammation in Spinal Dorsal Horn.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betulinic Acid; Drug Interactions; Ganglia, Spinal; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Oxidative Stress; Pain, Postoperative; Pentacyclic Triterpenes; Random Allocation; Rats; Rats, Sprague-Dawley; Remifentanil; Spinal Cord Dorsal Horn; Superoxide Dismutase; Triterpenes; Tumor Necrosis Factor-alpha; Tyrosine | 2018 |
The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Isoenzymes; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine; Up-Regulation | 2018 |
Protein nitration profile of CD3
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Biomarkers; Case-Control Studies; CD3 Complex; Cell Separation; Cytoskeletal Proteins; Energy Metabolism; Female; Gene Expression; Humans; Lymphocytes; Male; Middle Aged; Nitro Compounds; Nitrosative Stress; Oxidative Stress; Primary Cell Culture; Proteome; Signal Transduction; Tyrosine | 2018 |
Sitagliptin Protects Cardiac Function by Reducing Nitroxidative Stress and Promoting Autophagy in Zucker Diabetic Fatty (ZDF) Rats.
Topics: Animals; Autophagy; Beclin-1; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Lipids; Male; Myocytes, Cardiac; Nitrosative Stress; Obesity; Rats, Zucker; Sitagliptin Phosphate; Stroke Volume; Tyrosine; Ventricular Function, Left | 2018 |
Cardiac Effects of Hyperoxia During Resuscitation From Hemorrhagic Shock in Swine.
Topics: Animals; Gene Expression Regulation, Enzymologic; Hyperoxia; Myocardium; Nitric Oxide Synthase Type II; Resuscitation; Shock, Hemorrhagic; Swine; Tyrosine; Ventricular Function, Left | 2019 |
Long-Term Administration of Angiotensin (1-7) to
Topics: Angiotensin I; Animals; Diabetes Mellitus, Experimental; Gene Expression Regulation, Enzymologic; Kidney; Kidney Glomerulus; Male; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Peptide Fragments; Phosphorylation; Shear Strength; Tyrosine | 2018 |
Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration.
Topics: Administration, Inhalation; Animals; Brain Ischemia; Humans; Ischemic Preconditioning; Male; Nitrates; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Sevoflurane; Thioredoxins; Tyrosine | 2018 |
Redox regulation and NO/cGMP plus K
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Cuphea; Cyclic GMP; Endothelium, Vascular; Female; Hypertension, Renovascular; Nitric Oxide; Nitrites; Nitrosative Stress; Oxidation-Reduction; Oxidative Stress; Peptidyl-Dipeptidase A; Phytochemicals; Plant Extracts; Plants, Medicinal; Potassium Channels; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine; Vasodilator Agents; Vasopressins | 2018 |
Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis.
Topics: Animals; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Donors; Phosphorylation; RAW 264.7 Cells; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Toll-Like Receptor 4; Tyrosine | 2018 |
Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds.
Topics: Aged; Aged, 80 and over; Female; Glutathione; Humans; Interleukin-8; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Middle Aged; Oxidation-Reduction; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing | 2018 |
Hydromorphine postconditioning protects isolated rat heart against ischemia-reperfusion injury via activating P13K/Akt/eNOS signaling.
Topics: Animals; Creatine Kinase, MB Form; Disease Models, Animal; Isolated Heart Preparation; Male; Morphine Derivatives; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Troponin T; Tyrosine | 2018 |
Development of a surface plasmon resonance immunosensor and ELISA for 3-nitrotyrosine in human urine.
Topics: Antibodies; Antigens; Biosensing Techniques; Cross Reactions; Humans; Immunoassay; Limit of Detection; Ovalbumin; Surface Plasmon Resonance; Tyrosine | 2019 |
Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly.
Topics: Age Factors; Animals; Disease Models, Animal; Endothelial Cells; Liver; Male; Nitric Oxide; Phenotype; Rats; Rats, Wistar; Reperfusion Injury; Simvastatin; Tyrosine | 2020 |
The Potential Role of Neutrophil Gelatinase-Associated Lipocalin in the Development of Abdominal Aortic Aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apoptosis; Biomarkers; Caspase 3; Dilatation, Pathologic; Disease Progression; Female; Humans; Lipocalin-2; Male; Matrix Metalloproteinase 9; Middle Aged; Oxidative Stress; Retrospective Studies; Tyrosine; Up-Regulation; Vascular Remodeling | 2019 |
Signs of damage in pelvic floor muscles at the end of pregnancy in rabbits.
Topics: Animals; Biomarkers; Female; Glucuronidase; Muscle Fibers, Skeletal; Parity; Pelvic Floor; Postpartum Period; Pregnancy; Rabbits; Tyrosine | 2019 |
Localization of nitro-tyrosine immunoreactivity in human retina.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Axons; Female; Humans; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Middle Aged; Photoreceptor Cells, Vertebrate; Retina; Tissue Fixation; Tyrosine | 2019 |
An investigation of oxidative stress and coenzyme Q10 levels in patients with head and neck squamous cell carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Head and Neck Neoplasms; Humans; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Squamous Cell Carcinoma of Head and Neck; Tyrosine; Ubiquinone | 2019 |
Markers of lipid and protein peroxidation among Nigerian university students with dysmenorrhea.
Topics: Adolescent; Adult; alpha-Tocopherol; Antioxidants; Biomarkers; Case-Control Studies; Dysmenorrhea; Female; Humans; Lipid Peroxidation; Lipids; Male; Malondialdehyde; Oxidative Stress; Students; Tyrosine; Young Adult | 2019 |
Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Cardiotoxicity; Cell Communication; Cell-Derived Microparticles; Cells, Cultured; Endothelial Cells; Endothelin-1; Female; Humans; Male; Middle Aged; Neoplasms; Nitric Oxide; Reactive Oxygen Species; Signal Transduction; Tyrosine; Vascular Endothelial Growth Factor A | 2019 |
Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System.
Topics: Air Pollutants; Atmosphere; Chromatography, High Pressure Liquid; Electrochemistry; Environmental Monitoring; Humans; Particulate Matter; Reference Standards; Tyrosine | 2019 |
The prognostic value of nitrotyrosine levels in coronary heart disease: long-term evaluation in the Acute Coronary Syndrome Registry Strategy (ERICO study).
Topics: Acute Coronary Syndrome; Aged; Biomarkers; Coronary Disease; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Prospective Studies; Risk Factors; Survival Rate; Time Factors; Tyrosine | 2019 |
The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age.
Topics: Aging; Animals; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickness; Cell Proliferation; Diet, Western; Endothelial Cells; Fatty Acids; Male; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Oxidative Stress; Regional Blood Flow; Tyrosine | 2019 |
Nitration of hIAPP promotes its toxic oligomer formation and exacerbates its toxicity towards INS-1 cells.
Topics: Animals; Cell Line, Tumor; Heme; Hydrogen Peroxide; Islet Amyloid Polypeptide; Nitrites; Protein Binding; Protein Multimerization; Protein Processing, Post-Translational; Rats; Tyrosine | 2019 |
Endogenous advanced glycation end products in pancreatic islets after short-term carbohydrate intervention in obese, diabetes-prone mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Restricted; Diet, High-Fat; Dietary Carbohydrates; Glycation End Products, Advanced; Hyperglycemia; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Nitric Oxide Synthase Type II; Obesity; Tyrosine | 2019 |
Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis.
Topics: Actins; Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Humans; Malondialdehyde; Mice; Mice, Inbred C57BL; Molecular Dynamics Simulation; Muscle Contraction; Muscle Weakness; Muscle, Skeletal; Myosins; Oxidative Stress; Polymerization; Protein Processing, Post-Translational; Tyrosine | 2019 |
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.
Topics: Adult; Animals; Chemokine CCL2; Disease Models, Animal; Epoprostenol; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Kidney; Kidney Function Tests; Male; Mice, Inbred C57BL; Microvessels; Neovascularization, Physiologic; Regeneration; Transforming Growth Factor beta; Tyrosine; Uncoupling Protein 2; Ureteral Obstruction; Vascular Endothelial Growth Factor A | 2019 |
Carnosic Acid Pretreatment Attenuates Mitochondrial Dysfunction in SH-SY5Y Cells in an Experimental Model of Glutamate-Induced Excitotoxicity.
Topics: Abietanes; Apoptosis; Cell Line, Tumor; Cell Survival; Glutamic Acid; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Nitric Oxide; Oxidation-Reduction; Reactive Oxygen Species; Tyrosine | 2019 |
The influence of the low-energy defibrillating impulse on the endothelin-1 concentration in the left heart ventricle and blood serum of the healthy rabbits.
Topics: Animals; Blood Pressure; Electric Stimulation; Endothelin-1; Fatty Acid-Binding Proteins; Female; Heart Ventricles; Male; Myocardium; Rabbits; Tyrosine; Ventricular Function | 2019 |
Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Catalysis; Cell Line; Cisplatin; Janus Kinase 1; Mice; Nitric Oxide; Organ of Corti; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2019 |
Tyrosine nitration of mitochondrial proteins during myocardial ischemia and reperfusion.
Topics: Aconitate Hydratase; Animals; Electron Transport Chain Complex Proteins; Male; Mass Spectrometry; Mitochondria, Heart; Mitochondrial Proteins; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; Oxidation-Reduction; Rats; Rats, Wistar; Tyrosine | 2019 |
Study on the Effect of Severity of Maternal Iron Deficiency Anemia on Regulators of Angiogenesis in Placenta.
Topics: Adult; Anemia, Iron-Deficiency; Female; Humans; Immunohistochemistry; Nitric Oxide Synthase Type III; Placenta; Placenta Growth Factor; Pregnancy; Pregnancy Complications, Hematologic; Severity of Illness Index; Tyrosine; Vascular Endothelial Growth Factor A | 2019 |
Preconditioning but not postconditioning treatment with resveratrol substantially ameliorates post‑resuscitation myocardial dysfunction through the PI3K/Akt signaling pathway.
Topics: Animals; Cardiopulmonary Resuscitation; Heart; Male; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphorylation; Post-Cardiac Arrest Syndrome; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Resveratrol; Signal Transduction; Tyrosine; Ventricular Function, Left | 2019 |
Metformin prevents murine ovarian aging.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Cellular Senescence; Estradiol; Estrous Cycle; Female; Hypoglycemic Agents; Metformin; Mice; Ovarian Reserve; Ovary; Oxidative Stress; Sirtuin 1; Tyrosine | 2019 |
Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli.
Topics: alpha-Synuclein; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Protein Engineering; Recombinant Proteins; Tyrosine | 2019 |
Nitrosative Stress Is Associated with Dopaminergic Dysfunction in the HIV-1 Transgenic Rat.
Topics: Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; HIV Infections; HIV-1; Humans; Neurocognitive Disorders; Oxidative Stress; Rats; Rats, Transgenic; Tyrosine | 2019 |
Smooth muscle-specific deletion of MnSOD exacerbates diabetes-induced bladder dysfunction in mice.
Topics: Animals; bcl-2-Associated X Protein; Body Weight; Caspase 3; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Organ Size; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase; Tyrosine; Urinary Bladder Diseases | 2019 |
Characterization of the Site-Specific Acid-Base Equilibria of 3-Nitrotyrosine.
Topics: Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Structure; Tyrosine | 2019 |
The importance of inducible nitric oxide synthase and nitrotyrosine as prognostic markers for oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Humans; Leukoplakia, Oral; Mouth Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Prognosis; Signal Transduction; Tyrosine | 2019 |
Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring.
Topics: Animals; Disease Models, Animal; Female; Fibrosis; Kidney; Kidney Tubular Necrosis, Acute; Male; Malnutrition; Maternal-Fetal Exchange; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tyrosine; Ureteral Obstruction | 2019 |
Hesperidin ameliorates pancreatic β-cell dysfunction and apoptosis in streptozotocin-induced diabetic rat model.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Heat-Shock Proteins; Hesperidin; Homeodomain Proteins; Inflammation; Insulin; Insulin-Secreting Cells; Male; Malondialdehyde; Oxidative Stress; Pancreas; Protective Agents; Rats; Superoxide Dismutase; Trans-Activators; Transcription Factor CHOP; Tumor Necrosis Factor-alpha; Tyrosine | 2019 |
Nitric oxide synthase and VEGF expression in full-term placentas of obese women.
Topics: Adult; Female; Humans; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Obesity; Placenta; Pregnancy; Real-Time Polymerase Chain Reaction; Tyrosine; Vascular Endothelial Growth Factors | 2019 |
pH-Dependent Nitrotyrosine Formation in Ribonuclease A is Enhanced in the Presence of Polyethylene Glycol (PEG).
Topics: Animals; Cattle; Hydrogen-Ion Concentration; Kinetics; Molecular Docking Simulation; Peroxynitrous Acid; Polyethylene Glycols; Ribonuclease, Pancreatic; Tyrosine | 2019 |
Physical activity may drive healthy microvascular ageing via downregulation of p66
Topics: Age Factors; Aged; Arterioles; Biomarkers; Cross-Sectional Studies; DNA Methylation; Down-Regulation; Exercise; Female; Healthy Aging; Humans; Male; Middle Aged; Oxidative Stress; Retinal Vessels; Sedentary Behavior; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Venules | 2020 |
Maternal Exposure to Environmental Disruptors and Sexually Dimorphic Changes in Maternal and Neonatal Oxidative Stress.
Topics: Adult; Endocrine Disruptors; Environmental Pollutants; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Linear Models; Male; Maternal Exposure; Oxidative Stress; Pregnancy; Pregnancy Trimester, First; Principal Component Analysis; Proof of Concept Study; Sex Characteristics; Statistics, Nonparametric; Tyrosine | 2020 |
Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin in an Experimental Food Allergy Model.
Topics: Allergens; Animals; Cell Line, Tumor; Chymases; Disease Models, Animal; Female; Immunoglobulin A; Interferon-gamma; Interleukin-10; Lactoglobulins; Mice, Inbred BALB C; Milk Hypersensitivity; Nitro Compounds; Protein Stability; Proteolysis; Rats; Spleen; Tyrosine | 2019 |
AGEs impair Kv channel-mediated vasodilation of coronary arteries by activating the NF-κB signaling pathway in ZDF rats.
Topics: Animals; Coronary Vessels; Gene Silencing; Glycation End Products, Advanced; Heart Function Tests; Inflammation; Male; Models, Biological; Myocytes, Smooth Muscle; NF-kappa B; Oxidative Stress; Potassium Channels, Voltage-Gated; Protein Binding; Rats, Zucker; Receptor for Advanced Glycation End Products; Signal Transduction; Transcription Factor RelA; Tyrosine; Vasodilation | 2019 |
The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas.
Topics: Animals; Cornea; Corneal Injuries; DNA Damage; Female; Interleukin-1beta; Keratins; Nitric Oxide Synthase Type II; Oxidative Stress; Rabbits; Re-Epithelialization; Reactive Oxygen Species; Trehalose; Tyrosine; Ultraviolet Rays; Vascular Endothelial Growth Factor A; Wound Healing | 2019 |
Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia.
Topics: Acetylation; Adolescent; Adult; Aspirin; Cell Adhesion; Cyclooxygenase 2; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipoxins; Neutrophils; NF-kappa B; Oxidative Stress; Pre-Eclampsia; Pregnancy; Protein Processing, Post-Translational; Salicylic Acid; Thiobarbituric Acid Reactive Substances; Tyrosine; U937 Cells; Young Adult | 2020 |
Pathological changes induced by phosphine poisoning: a study on 8 children.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Aldehydes; Aluminum Compounds; Blood Chemical Analysis; Brain; Child; Child, Preschool; Female; Heart; Humans; Immunohistochemistry; Infant; Inhalation Exposure; Kidney; Liver; Lung; Male; Myocardium; Oxidative Stress; Phosphines; Statistics, Nonparametric; Tyrosine | 2020 |
Egg white consumption increases GSH and lowers oxidative damage in 110-week-old geriatric mice hearts.
Topics: Aging; Aldehydes; Amino Acids, Sulfur; Animal Feed; Animals; Antioxidants; Egg White; Glutathione; Glutathione Synthase; Inflammation; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Tyrosine | 2020 |
Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cell Movement; Cell Survival; Cyclooxygenase 2; Desiccation; Digestion; Gastrointestinal Tract; Heme Oxygenase-1; Interferons; Intestines; Lipopolysaccharides; Nitric Oxide Synthase Type II; Peptides; Phytochemicals; Rats; Reactive Oxygen Species; Solanum tuberosum; Stress, Mechanical; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2019 |
Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health.
Topics: Adult; Algorithms; Amino Acids, Branched-Chain; Biomarkers; Body Mass Index; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Glycation End Products, Advanced; Glycosylation; Humans; Kidney; Lysine; Male; Metabolic Diseases; Oxidation-Reduction; Severity of Illness Index; Tandem Mass Spectrometry; Tyrosine; Vascular Diseases | 2019 |
Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism.
Topics: Autism Spectrum Disorder; Child; Cross-Sectional Studies; Cytokines; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Monocytes; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Signal Transduction; Tyrosine | 2020 |
The Rectus Sheath Block (RSB) Analgesia Following Laparotomy Could Affect Malonidialdehyde (MDA) Concentrations in Benign Disease and Cancer.
Topics: Analgesia; Catalase; Female; Humans; Laparotomy; Male; Malondialdehyde; Middle Aged; Neoplasms; Nerve Block; Tyrosine | 2020 |
Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis.
Topics: Aging; Animals; Antigens, Neoplasm; Atherosclerosis; Disease Models, Animal; Female; Gene Knockdown Techniques; Glycation End Products, Advanced; Humans; Hyperlipidemias; Immunohistochemistry; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidative Stress; Plaque, Atherosclerotic; Rabbits; Receptor for Advanced Glycation End Products; Tyrosine | 2019 |
Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine.
Topics: Amino Acid Sequence; Binding Sites; Biocatalysis; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Models, Molecular; Nitrates; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Tryptophan; Tyrosine | 2020 |
The influence of Finnish sauna treatments on the concentrations of nitric oxide, 3-nitrotyrosine and selected markers of oxidative status in training and non-training men.
Topics: Adult; Antioxidants; Biomarkers; Blood Pressure; Body Temperature; Exercise; Heart Rate; Humans; Male; Nitric Oxide; Reactive Oxygen Species; Steam Bath; Tyrosine; Young Adult | 2020 |
Determination of Redox Status in Serum.
Topics: Animals; Antioxidants; Biomarkers; Enzyme-Linked Immunosorbent Assay; Free Radicals; Graft Rejection; Humans; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Transplantation, Heterologous; Tyrosine | 2020 |
Association between plasma dipeptidyl peptidase-4 activity to brain-derived neurotrophic factor ratio and depressive symptoms in middle-aged and older adults with normal glucose tolerance: A cross-sectional study.
Topics: Aged; Brain-Derived Neurotrophic Factor; Cross-Sectional Studies; Depression; Dipeptidyl Peptidase 4; F2-Isoprostanes; Glucose; Humans; Inflammation; Middle Aged; Oxidative Stress; Tyrosine | 2020 |
Peroxynitrite is a novel risk factor and treatment target of glaucoma.
Topics: Adult; Aged; Animals; Case-Control Studies; Caveolin 1; Female; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Male; Metalloporphyrins; Mice, Knockout; Middle Aged; Peroxynitrous Acid; Risk Factors; Tyrosine | 2020 |
Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome.
Topics: Animals; Apoptosis; Bronchiolitis Obliterans; Caspase 1; Cell Count; Enzyme Activation; Inflammasomes; Intercellular Signaling Peptides and Proteins; Interleukin-18; Interleukin-1beta; Male; Mast Cells; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Molecular Targeted Therapy; Nitric Oxide Synthase Type II; NLR Family, Pyrin Domain-Containing 3 Protein; Poly(ADP-ribose) Polymerases; Receptors, Formyl Peptide; Signal Transduction; Syndrome; Tyrosine | 2020 |
Effect of Curcumin on Protein Damage Induced by Rotenone in Dopaminergic PC12 Cells.
Topics: Animals; Cell Survival; Curcumin; Dopaminergic Neurons; Models, Biological; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Pesticides; Protein Carbamylation; Rats; Reactive Oxygen Species; Rotenone; Tyrosine | 2020 |
Serum Levels of Carbamylated LDL, Nitrotyrosine and Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 in Poorly Controlled Type 2 Diabetes Mellitus.
Topics: Adult; Albuminuria; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Scavenger Receptors, Class E; Tyrosine | 2019 |
Effect of serum 3-nitrotyrosine on the occurrence and development of carotid atherosclerosis in patients with essential hypertension.
Topics: Aged; Blood Pressure; Carotid Artery Diseases; Carotid Intima-Media Thickness; Essential Hypertension; Female; Homocysteine; Humans; Male; Regression Analysis; Risk Factors; Tyrosine | 2021 |
Advanced molecular recognition of 3-nitro-L-tyrosine: The use of zwitterion embedded molecularly imprinted mesoporous organosilica with sub-nanomolar sensitivity.
Topics: Biosensing Techniques; Fluorescent Dyes; Graphite; Limit of Detection; Molecular Imprinting; Porosity; Quantum Dots; Silicon Dioxide; Spectrometry, Fluorescence; Tyrosine | 2020 |
SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Hand Strength; Mice; Mice, Inbred C57BL; Muscles; Muscular Atrophy; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Resveratrol; Sirtuin 1; Tyrosine; Up-Regulation | 2020 |
Development of molecular and histological methods to evaluate stress oxidative biomarkers in sea bass (Dicentrarchus labrax).
Topics: Aldehydes; Animals; Aquaculture; Bass; Biomarkers; Central Nervous System; Fish Diseases; Gene Expression; Gills; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Immunohistochemistry; Immunoprecipitation; Kidney; Liver; Malondialdehyde; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Spleen; Stress, Physiological; Temperature; Tyrosine | 2020 |
Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats.
Topics: Animals; Anxiety; Behavior, Animal; Blood Coagulation; Blood-Brain Barrier; Brain Injuries, Traumatic; Cerebral Cortex; Homocysteine; Hyperhomocysteinemia; Inflammation; Intercellular Adhesion Molecule-1; Male; Methionine; Occludin; Oxidative Stress; Rats, Sprague-Dawley; Tyrosine; Zonula Occludens-1 Protein | 2021 |
Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix.
Topics: Chromatin Immunoprecipitation; Extracellular Matrix; Histones; Mass Spectrometry; Nitrosation; Protein Processing, Post-Translational; Proteomics; Protozoan Proteins; Trypanosoma cruzi; Tyrosine | 2020 |
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Topics: Acetylcholine; Adolescent; Adult; Aged; Aging; Animals; Antioxidants; Ascorbic Acid; Brachial Artery; Carotid Arteries; Cyclic N-Oxides; Dietary Supplements; Endothelium, Vascular; Gastrointestinal Microbiome; Humans; Methylamines; Mice; Mice, Inbred C57BL; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Spin Labels; Superoxides; Tyrosine; Vasodilation; Young Adult | 2020 |
Overcoming Near-Cognate Suppression in a Release Factor 1-Deficient Host with an Improved Nitro-Tyrosine tRNA Synthetase.
Topics: Amino Acyl-tRNA Synthetases; Catalytic Domain; Codon, Terminator; Computer Simulation; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Genetic Engineering; Models, Molecular; Mutation; Peptide Termination Factors; Protein Binding; Protein Conformation; Tyrosine | 2020 |
Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Arginase; beta-N-Acetylhexosaminidases; Catechin; Cell Proliferation; Interleukin-1beta; Interleukin-6; Ki-67 Antigen; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lectins; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Peroxidase; Proliferating Cell Nuclear Antigen; Tea; Triggering Receptor Expressed on Myeloid Cells-1; Tumor Necrosis Factor-alpha; Tyrosine | 2020 |
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Emphysema; Humans; Hypertension, Pulmonary; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Superoxides; Tobacco Smoke Pollution; Tyrosine | 2020 |
The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity.
Topics: Adult; Area Under Curve; Female; Glutathione; Glutathione Disulfide; Humans; Hypertension; Metabolic Syndrome; Middle Aged; Nitric Oxide; Nitrosative Stress; Obesity, Morbid; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; ROC Curve; Sulfhydryl Compounds; Tyrosine | 2020 |
HDAC6 Mediates Macrophage iNOS Expression and Excessive Nitric Oxide Production in the Blood During Endotoxemia.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endotoxemia; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Interferon Regulatory Factor-1; Macrophages, Peritoneal; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction; STAT1 Transcription Factor; Tyrosine | 2020 |
TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production.
Topics: Anemia, Sickle Cell; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Indoleacetic Acids; Luteinizing Hormone; Male; Mice, Transgenic; NADPH Oxidases; Nitric Oxide; Penis; Phosphorylation; Priapism; Receptors, GABA; Testis; Testosterone; Tyrosine | 2021 |
TLR4, RAGE, and p-JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox-sensitive phenolic olive compounds: Comparison with ibuprofen.
Topics: Aged; Aldehydes; Biomarkers; Cartilage, Articular; Cell Adhesion; Cell Survival; Chondrocytes; Female; Glycation End Products, Advanced; Humans; Ibuprofen; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Lipid Peroxides; Male; Middle Aged; Olea; Osteoarthritis; Oxidation-Reduction; Phenol; Phosphorylation; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Toll-Like Receptor 4; Tyrosine | 2020 |
Improved pharmacological properties of nitrotyrosine drug via fluorination: A theoretical study.
Topics: Antiparkinson Agents; Density Functional Theory; Drug Stability; Halogenation; Hydrogen Bonding; Models, Chemical; Neuroprotective Agents; Thermodynamics; Tyrosine | 2020 |
Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation.
Topics: Aldehydes; Animals; Carcinogenesis; DNA Damage; Female; Humans; Melanoma; Metformin; Mice; Oxidative Stress; Radiation Injuries, Experimental; Radiodermatitis; Skin; Skin Neoplasms; Tumor Suppressor Protein p53; Tyrosine; Ultraviolet Rays | 2020 |
Increased monocyte chemoattractant protein-1 and nitrotyrosine are associated with increased body weight in patients with rheumatoid arthritis after etanercept therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemokine CCL2; Etanercept; Female; Humans; Male; Middle Aged; Severity of Illness Index; Tyrosine; Weight Gain | 2020 |
Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period.
Topics: Aged; Biomarkers; Chromatography, Liquid; Colorectal Neoplasms; Female; Humans; Inflammation; Male; Metabolomics; Middle Aged; Nitrosative Stress; Oxidative Stress; Postoperative Complications; Postoperative Period; Prospective Studies; Reactive Oxygen Species; Reproducibility of Results; Sensitivity and Specificity; Surgical Wound Infection; Tandem Mass Spectrometry; Tyrosine | 2020 |
Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy.
Topics: Adenylate Kinase; Animals; Blood-Retinal Barrier; Caspase 3; Cell Death; Eye Proteins; Hindlimb; Interleukin-10; Ischemia; Ischemic Postconditioning; Male; Mice; Mice, Inbred C57BL; Microglia; Models, Animal; NADPH Oxidase 2; Neuroinflammatory Diseases; Optic Nerve Injuries; Oxidative Stress; Retinal Ganglion Cells; Superoxides; Transcription Factor Brn-3A; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Monitoring peptide tyrosine nitration by spectroscopic methods.
Topics: Azo Compounds; Circular Dichroism; Density Functional Theory; Molecular Dynamics Simulation; Peptides; Protein Structure, Secondary; Spectrum Analysis, Raman; Tyrosine | 2021 |
Cardioprotective Effect of Tangeretin by Inhibiting PTEN/AKT/mTOR Axis in Experimental Sepsis-Induced Myocardial Dysfunction.
Topics: Animals; Autophagy; Cardiomyopathies; Cardiotonic Agents; Cecum; Cell Death; Disease Models, Animal; Flavones; Glutathione; Heart; Ligation; Male; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Carbonylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Punctures; Rats, Sprague-Dawley; Sepsis; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Tyrosine | 2020 |
Maternal serum nitrotyrosine, 8-isoprostane and total antioxidant capacity levels in pre-gestational or gestational diabetes mellitus.
Topics: Adult; Antioxidants; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dinoprost; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy in Diabetics; Pregnancy Outcome; Russia; Tyrosine | 2020 |
On the Liquid Chemistry of the Reactive Nitrogen Species Peroxynitrite and Nitrogen Dioxide Generated by Physical Plasmas.
Topics: Diabetes Complications; Humans; Hydrogen Peroxide; Nitrogen; Nitrogen Dioxide; Nitrosative Stress; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Tyrosine; Wound Healing; Wounds and Injuries | 2020 |
Mitochondria exert age-divergent effects on recovery from spinal cord injury.
Topics: 2,4-Dinitrophenol; Aging; Animals; Cell Survival; Disease Progression; Female; Mice; Mice, Inbred C57BL; Mitochondria; Neurodegenerative Diseases; Neurons; Oxidative Stress; Oxygen Consumption; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries; Tyrosine; Uncoupling Agents | 2021 |
Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds.
Topics: 3T3 Cells; Animals; Burns; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Fish Oils; Hippophae; Keratinocytes; Mice; Re-Epithelialization; Sheep; Telomerase; Tyrosine; Wound Healing | 2021 |
Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice.
Topics: Administration, Oral; Alzheimer Disease; Animals; Behavior, Animal; Calcium Channel Agonists; Calcium Channels, T-Type; Cognition; Disease Models, Animal; Drug Administration Schedule; Hippocampus; Imidazoles; Male; Mice; Microglia; Molecular Structure; Olfactory Bulb; Oxidative Stress; Spatial Memory; Spiro Compounds; Tyrosine | 2021 |
Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart.
Topics: Acetylcholine; Animals; Blood Pressure; Choline O-Acetyltransferase; Down-Regulation; Gene Expression Regulation, Enzymologic; Histones; Homeostasis; Malondialdehyde; Mice; Mice, Transgenic; Myocardium; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Superoxide Dismutase; Tyrosine | 2021 |
Isolation and Characterization of Compounds from
Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Chalcones; Flavanones; Glycyrrhiza uralensis; Male; Mice; Mice, Inbred C57BL; Muscular Atrophy; Myoblasts; Myostatin; Plant Extracts; Tyrosine | 2021 |
Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response.
Topics: Animals; bcl-2-Associated X Protein; Cyclooxygenase 2; Gene Expression Regulation; Indican; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Topics: Brain Ischemia; Chromatography, Liquid; Fibrinogen; Hemostatics; Humans; Ischemic Stroke; Nitrates; Stroke; Tandem Mass Spectrometry; Tyrosine | 2021 |
Nitric oxide synthase-2 (NOS2) gene polymorphism c.1832C>T (Ser608Leu) associated with nitrosative stress in Fanconi anaemia.
Topics: Adolescent; Adult; Base Sequence; Case-Control Studies; Child; Child, Preschool; Fanconi Anemia; Gene Frequency; Genetic Association Studies; Humans; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrosative Stress; Polymorphism, Single Nucleotide; Tyrosine; Young Adult | 2021 |
PredNTS: Improved and Robust Prediction of Nitrotyrosine Sites by Integrating Multiple Sequence Features.
Topics: Computational Biology; Machine Learning; Protein Processing, Post-Translational; Proteins; Sequence Analysis, Protein; Support Vector Machine; Tyrosine | 2021 |
Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.
Topics: I-kappa B Kinase; NF-kappa B; NF-KappaB Inhibitor alpha; Peroxynitrous Acid; Phosphorylation; Protein Phosphatase 2; Superoxides; Tyrosine | 2021 |
Light-Controlled Tyrosine Nitration of Proteins.
Topics: alpha-Synuclein; Animals; Light; Mice; Nitrates; Oxidation-Reduction; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Metabolic shifts modulate lung injury caused by infection with H1N1 influenza A virus.
Topics: Animals; Epithelial Cells; Female; Glycolysis; Influenza A Virus, H1N1 Subtype; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Tyrosine; Virus Replication | 2021 |
Site-specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol-induced liver injury.
Topics: Amino Acid Sequence; Animals; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Ethanol; Histones; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Dynamics Simulation; Nitrates; Oxidative Stress; Tandem Mass Spectrometry; Tyrosine | 2021 |
A Method for Analysis of Nitrotyrosine-Containing Proteins by Immunoblotting Coupled with Mass Spectrometry.
Topics: Animals; Cattle; Electrophoresis, Gel, Two-Dimensional; Immunoblotting; Mass Spectrometry; Mitochondria, Heart; Mitochondrial Proteins; Peroxynitrous Acid; Tyrosine | 2021 |
Chronic Exercise Mitigates the Effects of Sirtuin Inhibition by Salermide on Endothelium-Dependent Vasodilation.
Topics: Animals; Aorta; Endothelium, Vascular; Histone Deacetylase Inhibitors; Male; Naphthols; Nitric Oxide Synthase Type III; Oxidative Stress; Phenylpropionates; Physical Conditioning, Animal; Physical Endurance; Rats, Wistar; Running; Signal Transduction; Sirtuin 1; Superoxide Dismutase; Time Factors; Tyrosine; Vasodilation | 2021 |
Sex and Age-Related Differences in Neuroinflammation and Apoptosis in
Topics: Aging; Animals; Apoptosis; Biomarkers; Caspase 3; Docosahexaenoic Acids; Ependymoglial Cells; Female; Inflammation; Male; Mice, Inbred BALB C; Microglia; NF-kappa B; Retina; Sex Characteristics; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
The role of oxidative stress in the susceptibility of noise-impaired cochleae to synaptic loss induced by intracochlear electrical stimulation.
Topics: Action Potentials; Aldehydes; Animals; Antioxidants; Cochlea; Cochlear Implants; Electric Stimulation; Evoked Potentials, Auditory, Brain Stem; Fatty Acids, Unsaturated; Guinea Pigs; Hair Cells, Auditory, Inner; Hearing Loss, Noise-Induced; Hydroxy Acids; Isoindoles; Organoselenium Compounds; Oxidative Stress; Severity of Illness Index; Synapses; Tyrosine | 2021 |
Oxidative stress parameters as biomarkers of bladder cancer development and progression.
Topics: Adult; Antioxidants; Biomarkers; Case-Control Studies; Disease Progression; Female; Free Radicals; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Sulfhydryl Compounds; Tyrosine; Urinary Bladder Neoplasms | 2021 |
Serum fractalkine and 3-nitrotyrosine levels correlate with disease severity in Parkinson's disease: a pilot study.
Topics: Chemokine CX3CL1; Disabled Persons; Humans; Motor Disorders; Parkinson Disease; Pilot Projects; Severity of Illness Index; Tyrosine | 2022 |
Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides.
Topics: Peptides; Proteasome Endopeptidase Complex; Proteins; Tyrosine | 2021 |
PPARβ down-regulation is involved in high glucose-induced endothelial injury via acceleration of nitrative stress.
Topics: Animals; Aorta, Thoracic; Diabetic Angiopathies; Down-Regulation; Endothelial Cells; Female; Glucose; Hyperglycemia; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrosative Stress; PPAR-beta; Rats, Sprague-Dawley; Signal Transduction; Tyrosine; Vasodilation | 2022 |
Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats.
Topics: Adipose Tissue; Animals; Carrier Proteins; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Administration Schedule; Endothelium, Vascular; Luteolin; Male; Oxidative Stress; Rats; Rats, Wistar; Tyrosine | 2021 |
Captopril alleviates oxidative damage in diabetic retinopathy.
Topics: Animals; Captopril; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Endothelial Cells; Glucose; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; Retinal Vessels; Streptozocin; Tyrosine; Vascular Endothelial Growth Factor A | 2022 |
Extended Prophylactic Effect of N-tert-Butyl-α-phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Azacitidine; Biomarkers; Cell Proliferation; Cyclic N-Oxides; DNA Methylation; Female; Nitrosation; Organ Size; Oxidative Stress; Placenta; Pregnancy; Proliferating Cell Nuclear Antigen; Rats, Inbred F344; Tyrosine | 2022 |
Oxidative Damage by 3-nitrotyrosine in Young Adults with Obesity: Its Implication in Chronic and Contagious Diseases.
Topics: Adolescent; Adult; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Obesity; Oxidative Stress; Tyrosine; Young Adult | 2023 |
A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.
Topics: Humans; Peroxynitrous Acid; Reactive Nitrogen Species; Serum; Tyrosine | 2022 |
Selective detection of nitrotyrosine using dual-fluorescent carbon dots.
Topics: Animals; Carbon; Fluorescent Dyes; Horses; Limit of Detection; Quantum Dots; Spectrometry, Fluorescence; Tyrosine | 2022 |
A new three-dimensional zinc(II) metal-organic framework as a fluorescence sensor for sensing the biomarker 3-nitrotyrosine.
Topics: Biomarkers; Metal-Organic Frameworks; Tyrosine; Zinc | 2022 |
A fluorophore anchored MOF for fast and sensitive sensing of Cu(II) and 3-nitrotyrosine in a physiological medium.
Topics: Biomarkers; Fluorescent Dyes; Metal-Organic Frameworks; Tyrosine | 2023 |
Multiphase Kinetic Modeling of Air Pollutant Effects on Protein Modification and Nitrotyrosine Formation in Epithelial Lining Fluid.
Topics: Air Pollutants; Air Pollution; Humans; Oxidative Stress; Tyrosine | 2023 |