tylosin and rosaramicin

tylosin has been researched along with rosaramicin* in 1 studies

Other Studies

1 other study(ies) available for tylosin and rosaramicin

ArticleYear
Repromicin derivatives with potent antibacterial activity against Pasteurella multocida.
    Journal of medicinal chemistry, 1997, Mar-14, Volume: 40, Issue:6

    Reductive amination of repromicin with polyfunctional amines has led to new macrolide antibacterial agents, some of which are highly potent against the Gram-negative pathogen Pasteurella multocida both in vitro and in a mouse infection model. A key element in this discovery was the recognition that among certain known macrolides increasing lipophilicity results in diminished in vivo activity. One repromicin derivative, 20-[N-[3-(dimethylamino)-propyl]-N-L-alanylamino]-20-deoxorepro micin (35), was selected for advanced evaluation. At 5 mg/kg, a single subcutaneous dose was found to control induced pasteurellosis in swine and induced respiratory disease in cattle.

    Topics: Animals; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Leucomycins; Macrolides; Mice; Microbial Sensitivity Tests; Molecular Structure; Pasteurella Infections; Pasteurella multocida; Tylosin

1997