Page last updated: 2024-08-26

tylophorine and phenanthrenes

tylophorine has been researched along with phenanthrenes in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (5.36)	18.7374
1990's	1 (1.79)	18.2507
2000's	20 (35.71)	29.6817
2010's	28 (50.00)	24.3611
2020's	4 (7.14)	2.80

Authors

Authors	Studies
Gopalakrishnan, C; Kameswaran, L; Natarajan, S; Shankaranarayan, D	1
Chen, Y; Fang, SD; Mi, JF; Xu, YM; Zhang, R	1
Raina, S; Raina, V	1
Gopalakrishnan, C; Kameswaran, L; Nazimudeen, SK; Shankaranarayanan, D	1
Wang, Q; Xie, L; Zhai, J	1
Ganguly, T; Sainis, KB	1
Baker, DC; Cheng, YC; Gao, W; Kaczmarek, C; Lam, W; Zhong, S	1
Baker, DC; Chen, T; Kaczmarek, C; Nygren, C; Turner, JF; Zhong, S	1
Chaudhuri, KN; Ghosh, B; Jha, S; Tepfer, D	2
Chen, WL; Lee, SJ; Tseng, HY; Wu, PL; Yang, CW	1
Chuang, TH; Lee, SJ; Wu, PL; Yang, CW	1
Baker, D; Cheng, YC; Gao, W; Koumpouras, F; Madri, JA; Pan, M; Shiah, HS; Tao, J; Wang, S; Yin, Z; You, X; Zhang, D; Zhao, H	1
Ihara, M	1
Bastow, KF; Brossi, A; Kendall, R; Lee, KH; Morris-Natschke, SL; Shi, Q; Wei, L	1
Fürstner, A; Kennedy, JW	1
Baker, DC; Cheng, YC; Choi, JY; Craft, J; Gao, W; Kashgarian, M; McNiff, JM; Odegard, J; Shiah, HS	1
Chuang, TH; Huang, WH; Lee, SJ; Wu, PL; Yang, CW	1
Bastow, KF; Brossi, A; Lee, KH; Morris-Natschke, SL; Nakagawa-Goto, K; Pan, SL; Shi, Q; Teng, CM; Wei, L; Wu, TS	1
Chemler, SR; Zeng, W	1
Deiters, A; McIver, A; Young, DD	1
Chao, YS; Chuang, TH; Lee, SJ; Lee, YZ; Wu, CM; Wu, PL; Yang, CW	1
Bastow, KF; Lee, KH; Lin, JC; Liu, YN; Shi, Q; Yang, PC; Yang, SC; Yang, X; Zhao, G	1
Giessert, RE; Herr, RJ; Rossiter, LM; Sakwa, SA; Slater, ML	1
Opatz, T; Stoye, A	1
Chen, AP; Cheng, YC; Gao, W; Svitkin, YV; Wang, Y	1
Barnard, DL; Chao, YS; Huang, CW; Jan, JT; Kang, IJ; Lee, SJ; Lee, YZ; Lin, D; Yang, CW; Yeh, TK	1
Fan, Z; Hu, Y; Liu, Y; Mi, N; Wang, K; Wang, Q	1
Lahm, G; Opatz, T; Stoye, A	1
Hwang, SB; Lim, YS; Ngo, HT; Pham, LV	1
Liu, Y; Park, CM; Xu, X	1
Bleeker, NP; Gay, BC; Georg, GI; Hong, KH; Niphakis, MJ	1
Gao, X; Han, J; He, X; Hong, Z; Huo, X; Jia, Z; Meng, X; Tian, G; Wang, P; Wang, Q; Wang, Z; Wu, M; Wu, Z; Xiong, S; Yin, Z; Zhang, Y; Zhao, L; Zhou, X	1
Chang, HY; Chao, YS; Hsu, HY; Lee, SJ; Lee, YZ; Qiu, YQ; Yang, CW; Yeh, TK	1
Cheng, YC; Gullen, EA; Lam, W; Lee, KH; Shi, Q; Wang, Y; Wong, HC; Yang, X	1
Opatz, T; Peez, TE; Stoye, A	1
Chen, F; Su, B; Wang, Q	1
Chang, HY; Chao, YS; Hsu, HY; Lee, SJ; Lee, YZ; Wu, CM; Yang, CW	1
Alhaider, AA; Kanaujia, PK; Kumar, R; Kumar, S; Saraswati, S	1
Liu, Y; Wang, Q; Zheng, Y	1
Deng, M; Su, B; Wang, Q; Zhang, H	1
Anton-Torrecillas, C; Gonzalez-Gomez, JC	1
Chang, CC; Hsu, HY; Lee, CH; Lee, SJ; Lee, YZ; Qiu, YQ; Yang, CW; Yang, RB	1
Chen, S; Cheng, H; Guo, W; Hong, Z; Wang, J; Wu, Z; Yin, Z; Yu, M; Zhao, L; Zhao, Q	1
Liu, GQ; Opatz, T; Reimann, M	1
Yamaoka, Y	1
Chang, HY; Chao, YS; Hsu, HY; Lee, SJ; Lee, YZ; Shih, C; Yang, CW	1
Baker, DC; Chen, SR; Cheng, Y; Cheng, YC; Dutschman, GE; Francis, S; Fürstner, A; Grill, SP; Gullen, EA; Ha, Y; Lam, W; Lee, KH; Lee, S; Wang, Y; Yang, X	1
Chen, L; Han, G; Liu, Y; Wang, Q; Wu, M	1
Astuti, P; Fakhrudin, N; Nugroho, AE; Pratama, NP; Wulandari, S	1
Atanasov, AG; Bernhard, D; Blažević, T; Czaloun, C; Dirsch, VM; Feldler, I; Grojer, C; Gruzdaitis, P; Heiss, EH; Joa, H; Messner, B; Proksch, P; Zeller, I	1
Choi, DH; Han, KM; Hwang, SB; Lim, YS; Luong, TTD; Mai, HN; Nguyen, HC; Nguyen, LP; Park, C; Park, EM	1
Chang, HY; Chen, L; Guo, HC; Lee, SJ; Lee, YZ; Yang, CW; Yang, RB; Zhao, GH	1
El-Kersh, DM; Islam, MT; Jamaddar, S; Mubarak, MS; Sarkar, C; Shilpi, JA; Uddin, SJ	1
Bai, J; Li, H; Li, M; Mang, Z; Zhang, S	1
Abdalla, AN; Abdullah, O; Chen, L; Fischer, PM; Guise, CP; Liu, Y; Omran, Z; Patterson, AV; Rauch, C; Sindi, IA; Smaill, JB; Wang, Q	1

Reviews

2 review(s) available for tylophorine and phenanthrenes

Article	Year
Efficient Synthesis of Polyaromatic Hydrocarbon via a Formal [2+2] Cycloaddition. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:11 Topics: Alkaloids; Cyclization; Cycloaddition Reaction; Heterocyclic Compounds; Hydrogenation; Indolizines; Phenanthrenes; Phenanthrolines; Polycyclic Aromatic Hydrocarbons	2016
Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data. Phytotherapy research : PTR, 2020, Volume: 34, Issue:10 Topics: Alkaloids; Animals; Antiviral Agents; Biological Products; Coronavirus; Coronavirus Infections; Drug Development; Humans; Indolizines; Ouabain; Phenanthrenes; Plant Extracts; Quinolizines; Triterpenes; Viral Proteins; Virus Replication	2020

Article

Year

Efficient Synthesis of Polyaromatic Hydrocarbon via a Formal [2+2] Cycloaddition.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:11

Topics: Alkaloids; Cyclization; Cycloaddition Reaction; Heterocyclic Compounds; Hydrogenation; Indolizines; Phenanthrenes; Phenanthrolines; Polycyclic Aromatic Hydrocarbons

2016

Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data.

Phytotherapy research : PTR, 2020, Volume: 34, Issue:10

Topics: Alkaloids; Animals; Antiviral Agents; Biological Products; Coronavirus; Coronavirus Infections; Drug Development; Humans; Indolizines; Ouabain; Phenanthrenes; Plant Extracts; Quinolizines; Triterpenes; Viral Proteins; Virus Replication

2020

Other Studies

54 other study(ies) available for tylophorine and phenanthrenes

Article	Year
Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica. The Indian journal of medical research, 1979, Volume: 69 Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Central Nervous System; Central Nervous System Depressants; Indolizines; Mice; Phenanthrenes; Plants, Medicinal; Rats	1979
[The application of circular dichroism on the structure analysis of natural products--diterpenoid dilactones and tylophorines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1992, Volume: 27, Issue:3 Topics: Alkaloids; Circular Dichroism; Diterpenes; Drugs, Chinese Herbal; Indolizines; Lactones; Molecular Conformation; Phenanthrenes	1992
The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects. Biochemical and biophysical research communications, 1980, Jun-30, Volume: 94, Issue:4 Topics: Adenylyl Cyclases; Adult; Age Factors; Alkaloids; Asthma; Child; Enzyme Activation; Female; Humans; Indolizines; Leukocytes; Male; Middle Aged; Phenanthrenes; Reference Values	1980
Effect of tylophorine, a major alkaloid of Tylophora indica, on immunopathological and inflammatory reactions. The Indian journal of medical research, 1980, Volume: 71 Topics: Alkaloids; Anaphylaxis; Animals; Arthritis, Experimental; Guinea Pigs; Indolizines; Mast Cells; Phenanthrenes; Rats; Rosette Formation	1980
Tylophorine B benzene solvate. Acta crystallographica. Section C, Crystal structure communications, 2000, Volume: 56 ( Pt 2) Topics: Alkaloids; Anti-Bacterial Agents; Antineoplastic Agents; Benzene; Crystallography, X-Ray; Indolizines; Models, Molecular; Molecular Conformation; Phenanthrenes; Plant Epidermis; Plant Extracts; Plants, Medicinal; Solvents	2000
Inhibition of cellular immune responses by Tylophora indica in experimental models. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, Volume: 8, Issue:5 Topics: Alkaloids; Animals; Apocynaceae; Cell Survival; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Hypersensitivity, Delayed; Immunity, Cellular; Indolizines; Isoquinolines; Lymphocytes; Mice; Phenanthrenes; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Sheep	2001
Novel mode of action of tylophorine analogs as antitumor compounds. Cancer research, 2004, Jan-15, Volume: 64, Issue:2 Topics: Alkaloids; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; Genes, Reporter; Humans; Indolizines; KB Cells; Liver Neoplasms; Male; Mice; Mice, Nude; Microscopy, Confocal; Phenanthrenes; Structure-Activity Relationship; Transfection; Tumor Stem Cell Assay	2004
A pair of epimeric 13-hydroxy-2,3,6,7-tetramethoxy-8b,11,12,12a,13,13a-hexahydro-9H-9a-azacyclopenta[b]triphenylene-10-ones. Acta crystallographica. Section C, Crystal structure communications, 2004, Volume: 60, Issue:Pt 3 Topics: Alkaloids; Crystallography, X-Ray; Hydrogen Bonding; Indolizines; Isoquinolines; Ketones; Molecular Conformation; Molecular Structure; Phenanthrenes; Pyrroles; Stereoisomerism	2004
Genetic transformation of Tylophora indica with Agrobacterium rhizogenes A4: growth and tylophorine productivity in different transformed root clones. Plant cell reports, 2005, Volume: 24, Issue:1 Topics: Alkaloids; Genetic Engineering; Indolizines; Phenanthrenes; Plant Roots; Plants, Genetically Modified; Rhizobium; Time Factors; Tissue Culture Techniques; Transformation, Genetic; Tylophora	2005
Anti-inflammatory mechanisms of phenanthroindolizidine alkaloids. Molecular pharmacology, 2006, Volume: 69, Issue:3 Topics: Adaptor Protein Complex 1; Alkaloids; Animals; Anti-Inflammatory Agents; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Ficus; Indolizines; Interferon-gamma; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Response Elements; Tumor Necrosis Factor-alpha	2006
Expedient synthesis and structure-activity relationships of phenanthroindolizidine and phenanthroquinolizidine alkaloids. Organic & biomolecular chemistry, 2006, Mar-07, Volume: 4, Issue:5 Topics: Alkaloids; Antineoplastic Agents; Biochemistry; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indolizines; Phenanthrenes; Phenanthrolines; Quinolizines; Structure-Activity Relationship	2006
Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response. Arthritis and rheumatism, 2006, Volume: 54, Issue:3 Topics: Alkaloids; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemokine CCL2; Collagen Type II; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Indolizines; Interleukin-1; Interleukin-12; Male; Mice; Mice, Inbred DBA; Phenanthrenes; Tumor Necrosis Factor-alpha	2006
Spontaneous plant regeneration in transformed roots and calli from Tylophora indica: Changes in morphological phenotype and tylophorine accumulation associated with transformation by Agrobacterium rhizogenes. Plant cell reports, 2006, Volume: 25, Issue:10 Topics: Alkaloids; DNA, Bacterial; Indolizines; Light; Phenanthrenes; Phenotype; Plant Roots; Plant Shoots; Plants, Genetically Modified; Regeneration; Rhizobium; Transformation, Genetic; Tylophora	2006
Syntheses of biologically active natural products and leading compounds for new pharmaceuticals employing effective construction of a polycyclic skeleton. Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:6 Topics: Alkaloids; Biological Products; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Indolizines; Models, Chemical; Oxides; Phenanthrenes; Polycyclic Compounds; Sesquiterpenes; Stereoisomerism	2006
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents. Bioorganic & medicinal chemistry, 2006, Oct-01, Volume: 14, Issue:19 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Indolizines; Lung Neoplasms; Magnetic Resonance Spectroscopy; Phenanthrenes; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship	2006
Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C. Chemistry (Weinheim an der Bergstrasse, Germany), 2006, Sep-25, Volume: 12, Issue:28 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Indoles; Indolizines; Phenanthrenes; Phenanthrolines	2006
Abrogation of skin disease in LUPUS-prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis and rheumatism, 2006, Volume: 54, Issue:10 Topics: Alkaloids; Animals; Autoantibodies; Disease Models, Animal; DNA; Female; Immunoglobulin G; Immunoglobulin M; Indolizines; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphatic Diseases; Mice; Mice, Inbred MRL lpr; NF-kappa B; Phenanthrenes; Skin Diseases; Splenomegaly	2006
Anti-inflammatory effects of 7-methoxycryptopleurine and structure-activity relations of phenanthroindolizidines and phenanthroquinolizidines. Biochemical and biophysical research communications, 2007, Mar-23, Volume: 354, Issue:4 Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 2; Humans; Indolizines; Macrophages; Mice; Nitric Oxide Synthase Type II; Phenanthrenes; Quinolizines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha	2007
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15 Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indolizines; Male; Mice; Mice, Nude; Neoplasm Transplantation; Phenanthrenes; Structure-Activity Relationship; Transplantation, Heterologous	2007
Total synthesis of (S)-(+)-tylophorine via enantioselective intramolecular alkene carboamination. The Journal of organic chemistry, 2008, Aug-01, Volume: 73, Issue:15 Topics: Alkaloids; Alkenes; Amination; Biological Products; Indolizines; Molecular Structure; Phenanthrenes; Stereoisomerism	2008
A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine. Chemical communications (Cambridge, England), 2008, Oct-21, Issue:39 Topics: Alkaloids; Aza Compounds; Chrysenes; Cyclization; Indolizines; Microwaves; Molecular Structure; Phenanthrenes; Stereoisomerism	2008
Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression. Biochemical and biophysical research communications, 2009, Aug-14, Volume: 386, Issue:1 Topics: Alkaloids; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cyclin A; Cyclin A2; Down-Regulation; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Indolizines; Phenanthrenes; Transcription, Genetic	2009
Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents. Journal of medicinal chemistry, 2009, Aug-27, Volume: 52, Issue:16 Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Indolizines; Models, Molecular; Molecular Conformation; NF-kappa B; Phenanthrenes; Phenanthrolines; Piperidines; Proto-Oncogene Proteins c-akt; Signal Transduction; Stereoisomerism; Structure-Activity Relationship	2009
A concise palladium-catalyzed carboamination route to (+/-)-tylophorine. The Journal of organic chemistry, 2009, Dec-18, Volume: 74, Issue:24 Topics: Alkaloids; Alkenes; Amination; Antineoplastic Agents, Phytogenic; Carbamates; Catalysis; Hydrocarbons, Brominated; Hydrocarbons, Cyclic; Indolizines; Models, Chemical; Palladium; Phenanthrenes; Pyrrolidines; Stereoisomerism	2009
Racemization-free synthesis of (S)-(+)-tylophorine from L-proline by radical cyclization. Organic letters, 2010, May-07, Volume: 12, Issue:9 Topics: Alkaloids; Cyclization; Indolizines; Phenanthrenes; Proline; Stereoisomerism	2010
DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism. PloS one, 2010, Jul-15, Volume: 5, Issue:7 Topics: Alkaloids; Amino Acids; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Humans; Indolizines; Phenanthrenes; Polymerase Chain Reaction; Polyribosomes; Protein Biosynthesis; Thymidine	2010
Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus. Antiviral research, 2010, Volume: 88, Issue:2 Topics: Alkaloids; Animals; Antiviral Agents; Apocynaceae; Chlorocebus aethiops; Coronavirus Infections; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Gastroenteritis, Transmissible, of Swine; Indolizines; Phenanthrenes; Phenanthrolines; Quinolizines; Rats; Rats, Sprague-Dawley; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Structure-Activity Relationship; Swine; Transmissible gastroenteritis virus; Tylophora; Vero Cells	2010
Design, synthesis, and antiviral evaluation of phenanthrene-based tylophorine derivatives as potential antiviral agents. Journal of agricultural and food chemistry, 2010, Dec-08, Volume: 58, Issue:23 Topics: Alkaloids; Antiviral Agents; Drug Design; Indolizines; Phenanthrenes; Plant Diseases; Structure-Activity Relationship; Tobacco Mosaic Virus	2010
A five-step synthesis of (±)-tylophorine via a nitrile-stabilized ammonium ylide. The Journal of organic chemistry, 2012, Aug-03, Volume: 77, Issue:15 Topics: Alkaloids; Indolizines; Molecular Structure; Nitriles; Phenanthrenes; Quaternary Ammonium Compounds	2012
Hepatitis C virus non-structural 5B protein interacts with cyclin A2 and regulates viral propagation. Journal of hepatology, 2012, Volume: 57, Issue:5 Topics: Alkaloids; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cyclin A2; HEK293 Cells; Hepacivirus; Humans; In Vitro Techniques; Indolizines; Kidney; Liver Neoplasms; Phenanthrenes; RNA, Small Interfering; Viral Nonstructural Proteins; Virus Replication	2012
Rhodium(III)-catalyzed intramolecular annulation through C-H activation: total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin. Angewandte Chemie (International ed. in English), 2012, Sep-10, Volume: 51, Issue:37 Topics: Alkaloids; Alkynes; Carbon; Catalysis; Cyclization; Heterocyclic Compounds, 4 or More Rings; Hydrogen; Indoles; Indolizines; Isoquinolines; Phenanthrenes; Phenanthrolines; Pyridones; Rhodium; Stereoisomerism	2012
Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs. Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19 Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Indolizines; Neoplasms; NF-kappa B; Phenanthrenes; Structure-Activity Relationship	2012
A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis. Journal of leukocyte biology, 2013, Volume: 93, Issue:1 Topics: Alkaloids; Animals; Blotting, Western; Colitis; Disease Models, Animal; Forkhead Transcription Factors; Indolizines; Lymphocyte Activation; Mice; Phenanthrenes; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; T-Lymphocytes, Regulatory; Up-Regulation	2013
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity. Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23 Topics: Administration, Oral; Alkaloids; Animals; Biological Availability; Cell Line; Cell Line, Tumor; Coronavirus; Drug Screening Assays, Antitumor; Humans; Indolizines; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Phenanthrenes; Virus Replication	2012
Cryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorine. PloS one, 2012, Volume: 7, Issue:12 Topics: Alkaloids; Cyclic AMP Response Element-Binding Protein; Indolizines; NF-kappa B; Phenanthrenes; Signal Transduction; Transcription Factor AP-1	2012
Left, right, or both? On the configuration of the phenanthroindolizidine alkaloid tylophorine from Tylophora indica. Journal of natural products, 2013, Feb-22, Volume: 76, Issue:2 Topics: Alkaloids; Indolizines; Molecular Structure; Phenanthrenes; Phenanthrolines; Tylophora	2013
An enantioselective strategy for the synthesis of (S)-tylophorine via one-pot intramolecular Schmidt/Bischler-Napieralski/imine-reduction cascade sequence. The Journal of organic chemistry, 2013, Mar-15, Volume: 78, Issue:6 Topics: Alkaloids; Alkylation; Azides; Imines; Indolizines; Molecular Structure; Phenanthrenes; Stereoisomerism	2013
c-Jun-mediated anticancer mechanisms of tylophorine. Carcinogenesis, 2013, Volume: 34, Issue:6 Topics: Activating Transcription Factor 1; Alkaloids; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Line, Tumor; Cyclin A2; Down-Regulation; Elongation Factor 2 Kinase; Eukaryotic Initiation Factors; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Indolizines; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NF-kappa B; Phenanthrenes; Phenanthrolines; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-jun; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA Interference; RNA, Small Interfering; Transcription Factor AP-1; Tylophora	2013
Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis. Molecular cancer, 2013, Jul-29, Volume: 12 Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Cell Movement; Cell Proliferation; Cell Survival; Cytokines; Disease Models, Animal; Female; Human Umbilical Vein Endothelial Cells; Humans; Indolizines; Male; Matrix Metalloproteinase 2; Mice; Molecular Conformation; Molecular Docking Simulation; Neoplasms; Neovascularization, Physiologic; Nitric Oxide; Phenanthrenes; Protein Binding; Protein Interaction Domains and Motifs; Signal Transduction; Tumor Burden; Tylophora; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays	2013
Collective asymmetric synthesis of (-)-antofine, (-)-cryptopleurine, (-)-tylophorine, and (-)-tylocrebrine with tert-butanesulfinamide as a chiral auxiliary. The Journal of organic chemistry, 2014, Apr-18, Volume: 79, Issue:8 Topics: Alkaloids; Butanes; Indoles; Indolizines; Isomerism; Molecular Structure; Phenanthrenes; Phenanthrolines; Stereoisomerism; Sulfonamides	2014
An enantioselective strategy for the total synthesis of (S)-tylophorine via catalytic asymmetric allylation and a one-pot DMAP-promoted isocyanate formation/Lewis acid catalyzed cyclization sequence. Organic & biomolecular chemistry, 2014, Jun-14, Volume: 12, Issue:22 Topics: Alkaloids; Catalysis; Chemistry, Organic; Cyclization; Indolizines; Isocyanates; Lewis Acids; Phenanthrenes; Phenanthrolines; Pyridines; Stereoisomerism	2014
Short asymmetric synthesis of phenanthroindolizidines through chiral homoallylic sulfinamines. Organic & biomolecular chemistry, 2014, Sep-28, Volume: 12, Issue:36 Topics: Alkaloids; Allyl Compounds; Amines; Indolizines; Molecular Structure; Oxidation-Reduction; Phenanthrenes; Phenanthrolines; Stereoisomerism; Sulfonium Compounds	2014
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget. Oncotarget, 2015, Feb-10, Volume: 6, Issue:4 Topics: Alkaloids; Animals; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cyclin D2; DNA Helicases; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Indolizines; MCF-7 Cells; Mice; Multiprotein Complexes; Neoplasms; Phenanthrenes; Poly-ADP-Ribose Binding Proteins; Protein Binding; Proto-Oncogene Proteins c-myb; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoproteins; RNA Helicases; RNA Interference; RNA Recognition Motif Proteins; RNA, Messenger; Tumor Burden; U937 Cells; Xenograft Model Antitumor Assays	2015
Targeted delivery of NK007 to macrophages to treat colitis. Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:7 Topics: Alginates; Alkaloids; Animals; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Chitosan; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drug Delivery Systems; Glucuronic Acid; Hexuronic Acids; Indolizines; Macrophages; Mice; Pharmaceutical Preparations; Phenanthrenes	2015
Total Synthesis of Phenanthroindolizidine Alkaloids by Combining Iodoaminocyclization with Free Radical Cyclization. The Journal of organic chemistry, 2016, 07-15, Volume: 81, Issue:14 Topics: Alkaloids; Chemistry, Organic; Cyclization; Free Radicals; Indoles; Indolizines; Isoquinolines; Magnetic Resonance Spectroscopy; Phenanthrenes; Phenanthrolines; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship; Temperature	2016
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity. Scientific reports, 2017, 06-22, Volume: 7, Issue:1 Topics: Alkaloids; Antiviral Agents; Benzamides; Coronavirus; Coronavirus Infections; Host-Pathogen Interactions; Indolizines; Janus Kinase 2; Models, Biological; NF-kappa B; Phenanthrenes; Phosphorylation; RNA, Viral; Signal Transduction; Transcription, Genetic; Virus Replication	2017
Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication. Scientific reports, 2017, 08-30, Volume: 7, Issue:1 Topics: Alkaloids; Allosteric Regulation; Allosteric Site; Hepacivirus; HSC70 Heat-Shock Proteins; Humans; Indolizines; Nucleotide Motifs; Phenanthrenes; Protein Binding; RNA, Viral; Virus Replication	2017
Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids. Journal of agricultural and food chemistry, 2018, Jan-31, Volume: 66, Issue:4 Topics: Alkaloids; Ammonium Compounds; Antiviral Agents; Drug Design; Drug Stability; Indolizines; Molecular Structure; Phenanthrenes; Solubility; Structure-Activity Relationship; Tobacco Mosaic Virus; Water	2018
Tylophorine Abrogates G2/M Arrest Induced by Doxorubicine and Promotes Increased Apoptosis in T47D Breast Cancer Cells Asian Pacific journal of cancer prevention : APJCP, 2018, Nov-29, Volume: 19, Issue:11 Topics: Alkaloids; Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Doxorubicin; Drug Therapy, Combination; Female; Humans; Indolizines; Phenanthrenes; Tumor Cells, Cultured	2018
Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 60 Topics: Alkaloids; Animals; Becaplermin; Cell Cycle; Cell Proliferation; Cyclin D1; Down-Regulation; Gene Expression Regulation; Humans; Indolizines; Myocytes, Smooth Muscle; Organ Culture Techniques; Phenanthrenes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Signal Transduction; Umbilical Veins	2019
5-Oxo-1-[(2,3,6,7-tetramethoxy-9-phenanthrenyl)methyl]-L-proline Inhibits Hepatitis C Virus Entry. Scientific reports, 2019, 05-13, Volume: 9, Issue:1 Topics: Alkaloids; Antiviral Agents; Cell Line, Tumor; Cell Survival; Drug Synergism; Drug Therapy, Combination; HEK293 Cells; Hepacivirus; Hepatitis C, Chronic; Hepatocytes; Humans; Indolizines; Interferon-alpha; Phenanthrenes; Primary Cell Culture; Proline; Sofosbuvir; Tetraspanin 28; Tylophora; Viral Envelope Proteins; Virus Internalization	2019
Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α. Pharmacological research, 2020, Volume: 152 Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Cycle Proteins; Cyclooxygenase 2; Edema; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Indolizines; Interferon-gamma; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Phenanthrenes; Proto-Oncogene Proteins c-myc; Rats, Sprague-Dawley; RAW 264.7 Cells; RNA, Messenger; Tumor Necrosis Factor-alpha	2020
Design, Synthesis and in Vitro Evaluation of Tylophorine Derivatives as Possible Antitumor Agents. Chemistry & biodiversity, 2020, Volume: 17, Issue:9 Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Indolizines; Molecular Structure; Phenanthrenes; Structure-Activity Relationship; Tylophora	2020
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents. Molecules (Basel, Switzerland), 2021, Jun-01, Volume: 26, Issue:11 Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; CHO Cells; Cricetulus; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Indoles; Indolizines; MCF-7 Cells; Molecular Structure; Phenanthrenes; Phenanthrolines; Prodrugs; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tumor Hypoxia	2021