Page last updated: 2024-08-17

tubercidin and adenosine kinase

tubercidin has been researched along with adenosine kinase in 95 studies

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-199024 (25.26)18.7374
1990's36 (37.89)18.2507
2000's25 (26.32)29.6817
2010's9 (9.47)24.3611
2020's1 (1.05)2.80

Authors

AuthorsStudies
Gupta, RS; Siminovitch, L1
Townsend, LB; Wotring, LL1
Berne, RM; Coleman, SD; Ely, SW; Matherne, GP1
Duley, JA; Montero, C; Simmonds, HA; Smolenski, RT1
de Jong, JW; Den Boer, PJ; Grootegoed, JA; Mackenbach, P1
Bontemps, F; van den Berghe, G1
Kather, H1
Barankiewicz, J; Gruber, HE; Jimenez, R; Ronlov, G1
Meghji, P; Middleton, KM; Newby, AC1
Bhaumik, D; Datta, AK1
Gupta, RS; Mehta, KD5
Gupta, RS; Singh, B; Stetsko, DK1
Fox, IH; Hurley, MC; Lin, B1
Baird-Lambert, J; Davies, LP; Marwood, JF1
Allan, PW; Bennett, LL; Brockman, RW; Rose, LM; Shaddix, SC1
Basuyau, JP; Chedeville, A; Claeyssens, S; Hamet, M; Lavoinne, A1
Dovey, HF; McKerrow, JH; Wang, CC1
Berens, RL; LaFon, SW; Marr, JJ; Nelson, DJ1
Holmquist, CA; Newby, AC1
Dalke, P; Lyda, TS; Magill, CW; Magill, JM1
Plagemann, PG; Wohlhueter, RM2
Lobelle-Rich, PA; Reeves, RE1
Baird-Lambert, JA; Davies, LP; Jamieson, DD; Kazlauskas, R1
Cass, CE; Phillips, JR; Selner, M1
Holmquist, CA; Illingworth, J; Newby, AC; Pearson, JD1
Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Node, K; Takeda, H1
Corsi, C; Fratti, S; Pazzagli, M; Pedata, F; Pepeu, G1
Fredholm, BB; Lloyd, HG1
el Kouni, MH; Iltzsch, MH; Tankersley, KO; Uber, SS1
Decking, UK; Haas, HL; Pak, MA; Schrader, J1
Bullough, DA; Montag, A; Mullane, KM; Young, MA; Zhang, C1
Bollen, M; Massillon, D; Stalmans, W; van de Werve, G1
Carson, DA; Cottam, HB; Di Pasquale, G; Raychaudhuri, A; Shih, HC; Wasson, DB1
Phillis, JW; Smith-Barbour, M1
Bontemps, F; Van den Berghe, G; Vincent, MF1
Sciotti, VM; Van Wylen, DG1
Bading, B; Deussen, A; Kelm, M; Schrader, J1
Flückiger-Isler, RE; Walter, P1
Geiger, JD; Parkinson, FE1
Hrnjez, BJ; Matthews, JB; Mun, EC; Smith, JA; Tally, KJ1
Gupta, RS1
Golembiowska, K; Sawynok, J; White, TD1
Cook, AF; Davies, LP1
Kroll, K; Stepp, DW1
DaRe, J; Foster, AC; Jelovich, LA; Miller, LP; Ugarkar, B; Yao, L1
Chopp, M; Jiang, N; Kowaluk, EA; Lee, CH; Mazdiyasni, H1
Dubey, RK; Gillespie, DG; Jackson, EK; Mi, Z1
Kalsi, KK; Kochan, Z; Smolenski, RT; Yacoub, MH; Zych, M1
Manthei, SA; Reiling, CM; Van Wylen, DG1
Hebb, MO; White, TD1
Gordon, PB; Grotterød, EM; Kovács, AL; Seglen, PO1
Jarvis, MF; Kowaluk, EA; Lynch, JJ1
Deussen, A; Kelm, M; Schäfer, S; Stappert, M1
Barankiewicz, J; Castellino, AJ; Dumas, DP; Erion, MD; Foster, AC; Gruber, HE; Ugarkar, BG; Wiesner, JB1
Britton, DR; Jarvis, MF; Kowaluk, EA; Lee, CH; Mikusa, J; Williams, M1
Dubey, RK; Gillespie, DG; Jackson, EK; Shue, H1
Brennan, RG; Ealick, SE; Mathews, II; Roos, DS; Schumacher, MA; Scott, DM; Ullman, B2
Abbracchio, MP; Camurri, A; Ceruti, S; Falzano, L; Fiorentini, C; Frank, C; Giammarioli, AM; Malorni, W; Rufini, S1
Browne, CE; DaRe, JM; Erion, MD; Kopcho, JJ; Schanzer, JM; Ugarkar, BG; Wiesner, JB1
Castellino, AJ; DaRe, JM; Erion, MD; Kopcho, JJ; Schanzer, JM; Ugarkar, BG; Wiesner, JB1
Gołembiowska, K; Zylewska, A1
Cerniway, RJ; Headrick, JP; Matherne, GP; Peart, J1
Baldwin, SA; Cass, CE; LaRivière, CG; Parkinson, FE; Powell, AE; Sinclair, CJ; Xiong, W; Young, JD1
Gray, CC; Kalsi, KK; Kochan, Z; Smolenski, RT; Yacoub, MH; Zych, M1
Cioroch, M; Makarewicz, W; Skladanowski, AC; Tkacz, K1
Benton, HP; Kollias-Baker, C; MacDonald, MH; Tesch, AM1
Kumar, R; Sharma, BK; Singh, P1
Boison, D; Fritschy, JM; Gouder, N; Scheurer, L1
Benton, HP; MacDonald, MH; Petrov, R; Tesch, AM1
Boison, D; Crestani, F; Fedele, DE; Gabernet, L; Gouder, N; Güttinger, M; Rülicke, T; Scheurer, L1
Boyer, SH; Erion, MD; Gomez-Galeno, JE; Kopcho, J; Matelich, MC; Mendonca, R; Nagahisa, A; Nakane, M; Ollis, K; Solbach, J; Tsuchiya, M; Ugarkar, BG; Wiesner, JB1
Chambers, MG; Mason, RM; Mistry, D1
Boison, D; Pignataro, G; Simon, RP1
Allan, PW; Liu, MC; Long, MC; Luo, MZ; Parker, WB; Sartorelli, AC1
Bhagwat, SS; Cowart, MD; Gomtsyan, A; Jakob, CL; Jarvis, MF; Kowaluk, EA; Lee, CH; Matulenko, MA; Muchmore, SW; Severin, JM; Smith, RA; Stewart, AO; Yu, H1
Brdar, B; Reich, E1
Carneiro, FS; Carneiro, ZN; Giachini, FRC; Inscho, EW; Leite, R; Lima, VV; Tostes, RC; Webb, RC1
Cho, CY; Geierstanger, BH; Ginsberg, MH; Goldfinger, LE; Hong, J; Lee, J; Nam, TG; Orth, AP; Peters, EC; Schultz, PG1
Boison, D; Dale, N; Etherington, LA; Frenguelli, BG; Irving, AJ; Meechan, L; Patterson, GE1
Boison, D; Li, T; Shen, HY1
Fukuda, M; Hino, H; Ishii, E; Kuzume, K; Morimoto, T; Suzuki, Y1
Bhutoria, S; Ghoshal, N1
Agarwal, T; Cui, XA; Gupta, RS; Singh, B1
Birkus, G; Bourderioux, A; Cihlar, T; Dzubák, P; Feng, JY; Hajdúch, M; Hocek, M; Konecný, P; Naus, P; Perlíková, P; Pichová, I; Pohl, R; Ray, AS; Stray, KM; Votruba, I; Wang, T1
Boison, D; Granja, TF; Köhler, D; Morote-García, JC; Rosenberger, P; Schneider, M; Straub, A; Streienberger, A1
Boison, D; Ciancetta, A; Jacobson, KA; Osborne, D; Toti, KS1
Acharya, MM; Allen, BD; Baddour, AA; Baulch, JE; Giedzinski, E; Kawashita, T; Nguyen, TH; Parihar, VK; Syage, AR; Yoon, N; Yu, L1
Bigej, R; Boison, D; Friedman, JL; Saleumvong, B; Sandau, US; Yahya, M1
Ashraf, O; Boison, D; Chitravanshi, V; Fedele, DE; Huynh, T; Murugan, M; Purnell, BS1

Other Studies

95 other study(ies) available for tubercidin and adenosine kinase

ArticleYear
Genetic and biochemical studies with the adenosine analogs toyocamycin and tubercidin: mutation at the adenosine kinase locus in Chinese hamster cells.
    Somatic cell genetics, 1978, Volume: 4, Issue:6

    Topics: Adenosine Kinase; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Female; Mutation; Ovary; Phenotype; Phosphotransferases; Ribonucleosides; Toyocamycin; Tubercidin

1978
Study of the cytotoxicity and metabolism of 4-amino-3-carboxamido-1-(beta-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine using inhibitors of adenosine kinase and adenosine deaminase.
    Cancer research, 1979, Volume: 39, Issue:8

    Topics: Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Leukemia L1210; Mice; Nucleoside Deaminases; Phosphotransferases; Ribonucleosides; Tubercidin

1979
Inhibition of adenosine metabolism increases myocardial interstitial adenosine concentrations and coronary flow.
    Journal of molecular and cellular cardiology, 1992, Volume: 24, Issue:11

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Coronary Circulation; Extracellular Space; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Myocardium; Perfusion; Tubercidin; Vascular Resistance

1992
Effects of adenosine analogues on ATP concentrations in human erythrocytes. Further evidence for a route independent of adenosine kinase.
    Biochemical pharmacology, 1991, Oct-09, Volume: 42, Issue:9

    Topics: Adenine Phosphoribosyltransferase; Adenosine Kinase; Adenosine Triphosphate; Erythrocytes; Humans; Hypoxanthine; Hypoxanthines; Pentostatin; Tubercidin

1991
Effects of glucose and adenosine on the ATP content of hamster spermatids.
    Reproduction, fertility, and development, 1990, Volume: 2, Issue:2

    Topics: Adenine; Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cricetinae; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Fructose; Galactose; Glucose; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Male; Mannose; Spermatids; Tubercidin

1990
Adenine nucleotide catabolism in human erythrocytes: pathways and regulation.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:2-3

    Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Monophosphate; Erythrocytes; Humans; Hydrolysis; Hypoxanthines; Kinetics; Nucleotidases; Pentostatin; Phosphorylation; Tubercidin

1990
Pathways of purine metabolism in human adipocytes. Further evidence against a role of adenosine as an endogenous regulator of human fat cell function.
    The Journal of biological chemistry, 1990, Jan-05, Volume: 265, Issue:1

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Adipose Tissue; Glycerophosphates; Humans; Hypoxanthine; Hypoxanthines; Inosine; Inosine Monophosphate; Isoproterenol; Lipolysis; Pentostatin; Purines; Tubercidin

1990
Selective adenosine release from human B but not T lymphoid cell line.
    The Journal of biological chemistry, 1990, Sep-15, Volume: 265, Issue:26

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; B-Lymphocytes; Cell Line; Deoxyglucose; Hypoxanthine; Hypoxanthines; Inosine; Kinetics; Models, Biological; Pentostatin; Rats; T-Lymphocytes; Tubercidin

1990
Absolute rates of adenosine formation during ischaemia in rat and pigeon hearts.
    The Biochemical journal, 1988, Feb-01, Volume: 249, Issue:3

    Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase; Adenosine Kinase; Adult; AMP Deaminase; Animals; Columbidae; Coronary Disease; Female; Heart; Histocytochemistry; Humans; Male; Middle Aged; Myocardium; Nucleotidases; Nucleotides; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Species Specificity; Tubercidin

1988
Reaction kinetics and inhibition of adenosine kinase from Leishmania donovani.
    Molecular and biochemical parasitology, 1988, Volume: 28, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Kinetics; Leishmania donovani; Methylthioinosine; Phosphotransferases; Substrate Specificity; Tubercidin

1988
Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells.
    Biochemical and biophysical research communications, 1985, Jul-31, Volume: 130, Issue:2

    Topics: Adenosine; Adenosine Kinase; Amides; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Drug Resistance; Female; Formycins; Methylthioinosine; Mutation; Ovary; Phosphorylation; Phosphotransferases; Pyrazoles; Ribonucleosides; Ribose; Toyocamycin; Tubercidin

1985
Inhibition of metabolic cooperation by phorbol esters in a cell culture system based on adenosine kinase deficient mutants of V79 cells.
    Carcinogenesis, 1985, Volume: 6, Issue:9

    Topics: Adenosine; Adenosine Kinase; Animals; Cell Communication; Cell Count; Cell Line; Cricetinae; Cricetulus; Diphtheria Toxin; Dose-Response Relationship, Drug; Drug Resistance; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Phorbol Esters; Phorbols; Phosphorylation; Phosphotransferases; Tetradecanoylphorbol Acetate; Tubercidin

1985
Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.
    The Journal of biological chemistry, 1985, Dec-15, Volume: 260, Issue:29

    Topics: Adenosine Diphosphate; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Deoxyadenosines; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Methylthioinosine; Nucleosides; Nucleotides; Phosphorylation; Phosphotransferases; Placenta; Potassium Chloride; Pregnancy; Tubercidin; Vidarabine

1985
Novel mutants of CHO cells resistant to adenosine analogs and containing biochemically altered form of adenosine kinase in cell extracts.
    Somatic cell and molecular genetics, 1986, Volume: 12, Issue:1

    Topics: Adenosine; Adenosine Kinase; Animals; Antibiotics, Antineoplastic; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Formycins; Genetic Markers; Hybrid Cells; Mutation; Phenotype; Phosphorylation; Phosphotransferases; Tubercidin

1986
Immunological studies with different classes of mutants affected at the adenosine kinase locus in CHO cells.
    Somatic cell and molecular genetics, 1986, Volume: 12, Issue:3

    Topics: Adenosine Kinase; Amides; Animals; Antibody Specificity; Cell Line; Cricetinae; Cricetulus; Cross Reactions; Drug Resistance; Female; Formycins; Immunosorbent Techniques; Methylthioinosine; Mutation; Ovary; Phosphotransferases; Pyrazoles; Ribonucleosides; Ribose; Toyocamycin; Tubercidin

1986
Studies on several pyrrolo[2,3-d]pyrimidine analogues of adenosine which lack significant agonist activity at A1 and A2 receptors but have potent pharmacological activity in vivo.
    Biochemical pharmacology, 1986, Sep-15, Volume: 35, Issue:18

    Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Brain; Cyclic AMP; Guanosine; Guinea Pigs; Heart Rate; Male; Mice; Muscle Relaxation; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Tubercidin

1986
Genetic and biochemical characteristics of three different types of mutants of mammalian cells affected in adenosine kinase.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Adenosine Kinase; Animals; Binding, Competitive; Biological Transport; Cell Line; Cricetinae; Cross Reactions; Drug Resistance; Formycins; Mutation; Phosphotransferases; Purine Nucleosides; Structure-Activity Relationship; Tubercidin

1986
Alterations in nucleotide pools induced by 3-deazaadenosine and related compounds. Role of adenylate deaminase.
    Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7

    Topics: Adenine; Adenosine Kinase; Alanine; Aminoglycosides; AMP Deaminase; Animals; Anti-Bacterial Agents; Cell Survival; Coformycin; Hypoxanthine; Hypoxanthines; Mice; Nucleotide Deaminases; Nucleotides; Time Factors; Tubercidin

1988
Influence of 2-chloroadenosine on the nucleotide content of isolated rat hepatocytes.
    FEBS letters, 1988, May-23, Volume: 232, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Diphosphate; Adenosine Kinase; Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Kinetics; Liver; Male; Nucleotides; Phosphorylation; Piperazines; Rats; Rats, Inbred Strains; Spectrophotometry; Tubercidin

1988
Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules.
    Molecular and biochemical parasitology, 1985, Volume: 16, Issue:2

    Topics: Adenosine; Adenosine Kinase; Adenosine Monophosphate; Animals; Antibiotics, Antineoplastic; Formycins; Movement; Nucleotides; Purine-Nucleoside Phosphorylase; Ribonucleosides; Schistosoma mansoni; Substrate Specificity; Tubercidin; Vidarabine

1985
Inosine analogs. Their metabolism in mouse L cells and in Leishmania donovani.
    The Journal of biological chemistry, 1985, Aug-15, Volume: 260, Issue:17

    Topics: Adenosine Kinase; Adenosine Triphosphate; Animals; Cell Line; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Fibroblasts; Guanosine Triphosphate; Inosine; Inosine Triphosphate; Leishmania; Mice; Tubercidin

1985
Adenosine production inside rat polymorphonuclear leucocytes.
    The Biochemical journal, 1981, Nov-15, Volume: 200, Issue:2

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Chromatography, High Pressure Liquid; Coformycin; Neutrophils; Nucleotidases; Pentostatin; Rats; Tubercidin

1981
Adenosine kinase-deficient mutant of Neurospora crassa.
    Journal of bacteriology, 1982, Volume: 152, Issue:3

    Topics: Adenosine; Adenosine Kinase; Kinetics; Mutation; Neurospora; Neurospora crassa; Phosphotransferases; Purine Nucleosides; Purine Nucleotides; Tubercidin

1982
Adenosine metabolism in wild-type and enzyme-deficient variants of Chinese hamster ovary and Novikoff rat hepatoma cells.
    Journal of cellular physiology, 1983, Volume: 116, Issue:2

    Topics: 2-Aminopurine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Animals; Cell Division; Cell Line; Cell-Free System; Coformycin; Cricetinae; Female; Kinetics; Liver Neoplasms, Experimental; Ovary; Pentostatin; Phosphorylation; Phosphotransferases; Purine-Nucleoside Phosphorylase; Rats; Tubercidin

1983
Formycin B-resistant mutants of Chinese hamster ovary cells: novel genetic and biochemical phenotype affecting adenosine kinase.
    Molecular and cellular biology, 1983, Volume: 3, Issue:8

    Topics: Adenosine; Adenosine Kinase; Animals; Antibiotics, Antineoplastic; Biological Transport; Cell Line; Cells, Cultured; Cricetinae; Drug Resistance; Formycins; Mutation; Phosphotransferases; Toyocamycin; Tubercidin

1983
The partial purification and characterization of adenosine kinase from Entamoeba histolytica.
    The American journal of tropical medicine and hygiene, 1983, Volume: 32, Issue:5

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Chromatography, Affinity; Entamoeba histolytica; Glycerol; Kinetics; Phosphotransferases; Substrate Specificity; Tubercidin; Vidarabine

1983
Halogenated pyrrolopyrimidine analogues of adenosine from marine organisms: pharmacological activities and potent inhibition of adenosine kinase.
    Biochemical pharmacology, 1984, Feb-01, Volume: 33, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Adenosine Kinase; Adenylyl Cyclases; Animals; Brain; Bronchodilator Agents; Cardiovascular System; Central Nervous System; Guinea Pigs; In Vitro Techniques; Male; Marine Biology; Mice; Phosphotransferases; Rats; Ribonucleosides; Theophylline; Tubercidin

1984
Resistance to 9-beta-D-arabinofuranosyladenine in cultured leukemia L 1210 cells.
    Cancer research, 1983, Volume: 43, Issue:10

    Topics: Adenosine Kinase; Animals; Cell Division; Coformycin; DNA Replication; Drug Resistance; Leukemia L1210; Mice; Pentostatin; Tubercidin; Vidarabine

1983
The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat.
    The Biochemical journal, 1983, Aug-15, Volume: 214, Issue:2

    Topics: Adenosine; Adenosine Kinase; Animals; Cells, Cultured; Coformycin; Heart; In Vitro Techniques; Male; Myocardium; Neutrophils; Pentostatin; Perfusion; Rats; Rats, Inbred Strains; Tubercidin

1983
Adenosine and tubercidin binding and transport in Chinese hamster ovary and Novikoff rat hepatoma cells.
    Journal of cellular physiology, 1983, Volume: 116, Issue:2

    Topics: Adenosine; Adenosine Kinase; Animals; Biological Transport; Cell Line; Cricetinae; Female; Kinetics; Liver Neoplasms, Experimental; Ovary; Phosphorylation; Rats; Ribonucleosides; Thymidine; Tubercidin; Uridine

1983
Activation of protein kinase C increases adenosine production in the hypoxic canine coronary artery through the extracellular pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 1995, Volume: 15, Issue:12

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Arteries; Coronary Vessels; Dogs; Enzyme Activation; Hypoxia; In Vitro Techniques; Pentostatin; Protein Kinase C; Tubercidin

1995
Regulation of extracellular adenosine levels in the striatum of aging rats.
    Brain research, 1995, Jun-26, Volume: 684, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Aging; Amino Acids; Animals; Corpus Striatum; Enzyme Inhibitors; Extracellular Space; Male; Microdialysis; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tubercidin

1995
Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices.
    Neurochemistry international, 1995, Volume: 26, Issue:4

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Basal Metabolism; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Purines; Rats; Tubercidin

1995
Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii.
    Biochemical pharmacology, 1995, May-17, Volume: 49, Issue:10

    Topics: Adenosine; Adenosine Kinase; Animals; Antiprotozoal Agents; Drug Design; Ligands; Purine Nucleosides; Structure-Activity Relationship; Toxoplasma; Tubercidin

1995
Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices.
    Neuropharmacology, 1994, Volume: 33, Issue:9

    Topics: Adenosine; Adenosine Kinase; Animals; Hippocampus; In Vitro Techniques; Inosine; Kinetics; Membrane Potentials; Neurons; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Tubercidin; Xanthines

1994
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo.
    The Journal of clinical investigation, 1994, Volume: 94, Issue:4

    Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Blood Physiological Phenomena; Coronary Thrombosis; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Erythrocytes; Humans; Male; Plasma; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Regional Blood Flow; Ribonucleosides; Theophylline; Tubercidin

1994
Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor.
    The Biochemical journal, 1994, Apr-01, Volume: 299 ( Pt 1)

    Topics: Adenosine Kinase; Animals; Glucagon; Glycogen Synthase; Liver; Male; Peptides; Phosphorylase Kinase; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tubercidin; Vasopressins

1994
New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation.
    Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22

    Topics: Adenosine Kinase; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, Cultured; Drug Evaluation, Preclinical; Humans; Kinetics; Lymphocytes; Pleurisy; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Tubercidin

1993
The adenosine kinase inhibitor, 5-iodotubercidin, is not protective against cerebral ischemic injury in the gerbil.
    Life sciences, 1993, Volume: 53, Issue:6

    Topics: Adenosine Kinase; Animals; Body Temperature; Brain Ischemia; Gerbillinae; Hippocampus; Male; Motor Activity; Tubercidin

1993
Mechanisms of elevation of adenosine levels in anoxic hepatocytes.
    The Biochemical journal, 1993, Mar-15, Volume: 290 ( Pt 3)

    Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Amobarbital; Animals; Carbon Dioxide; Cell Membrane; Liver; Male; Nitrogen; Oxygen; Pentostatin; Phosphoric Monoester Hydrolases; Potassium Cyanide; Rats; Rats, Wistar; Tubercidin

1993
Increases in interstitial adenosine and cerebral blood flow with inhibition of adenosine kinase and adenosine deaminase.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1993, Volume: 13, Issue:2

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Brain; Cerebrovascular Circulation; Dialysis Solutions; Dose-Response Relationship, Drug; Extracellular Space; Hypoxanthine; Hypoxanthines; Inosine; Male; Rats; Rats, Wistar; Tubercidin

1993
Formation and salvage of adenosine by macrovascular endothelial cells.
    The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 2

    Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Calcimycin; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Firefly Luciferin; Kinetics; Luciferases; Microspheres; Phosphorylation; Swine; Tubercidin

1993
Stimulation of rat liver glycogen synthesis by the adenosine kinase inhibitor 5-iodotubercidin.
    The Biochemical journal, 1993, May-15, Volume: 292 ( Pt 1)

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Kinase; Adenosine Triphosphate; Amino Acids; Animals; Cells, Cultured; Liver; Liver Glycogen; Male; Rats; Rats, Wistar; Tubercidin

1993
Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:3

    Topics: Adenosine Kinase; Animals; Cricetinae; Dose-Response Relationship, Drug; Kinetics; Muscle, Smooth; Nucleosides; Radioligand Assay; Tubercidin

1996
Adenosine scavenging: a novel mechanism of chloride secretory control in intestinal epithelial cells.
    Surgery, 1996, Volume: 120, Issue:2

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Biological Transport; Buffers; Cells, Cultured; Chlorides; Chromatography, High Pressure Liquid; Cyclic AMP; Dipyridamole; Enzyme Inhibitors; Humans; Intestinal Mucosa; Membrane Proteins; Nucleosides; Phosphodiesterase Inhibitors; Phosphorylation; Tubercidin; Vasodilator Agents

1996
Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase.
    Biochemistry and molecular biology international, 1996, Volume: 39, Issue:3

    Topics: Adenosine; Adenosine Kinase; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arsenates; Cattle; CHO Cells; Cricetinae; Enzyme Inhibitors; Enzyme Stability; Kinetics; Liver; Magnesium; Mutation; Phosphates; Temperature; Toyocamycin; Tubercidin

1996
Adenosine kinase inhibitors augment release of adenosine from spinal cord slices.
    European journal of pharmacology, 1996, Jun-27, Volume: 307, Issue:2

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Deoxyadenosines; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Pentostatin; Rats; Rats, Sprague-Dawley; Spinal Cord; Tubercidin

1996
Inhibition of adenosine kinase and adenosine uptake in guinea-pig CNS tissue by halogenated tubercidin analogues.
    Life sciences, 1995, Mar-17, Volume: 56, Issue:17

    Topics: Adenosine; Adenosine Kinase; Animals; Cerebral Cortex; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Tubercidin

1995
Adenosine kinetics in canine coronary circulation.
    The American journal of physiology, 1996, Volume: 270, Issue:4 Pt 2

    Topics: Adenosine; Adenosine Kinase; Animals; Biological Transport; Capillaries; Computer Simulation; Coronary Circulation; Dipyridamole; Dogs; Endothelium, Vascular; Female; Hemodynamics; In Vitro Techniques; Indicator Dilution Techniques; Kinetics; Male; Models, Cardiovascular; Nitroglycerin; Tubercidin; Veins

1996
Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats.
    Neuroscience letters, 1996, Dec-13, Volume: 220, Issue:2

    Topics: Adenosine Kinase; Animals; Cerebral Arteries; Cerebral Infarction; Cerebrovascular Disorders; Constriction, Pathologic; Male; Rats; Tubercidin

1996
Adenosine kinase inhibition protects brain against transient focal ischemia in rats.
    European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3

    Topics: Adenosine Kinase; Animals; Arterial Occlusive Diseases; Body Temperature; Body Weight; Brain; Cerebral Infarction; Enzyme Inhibitors; Ischemic Attack, Transient; Male; Neuroprotective Agents; Rats; Rats, Wistar; Tubercidin

1997
Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors.
    Circulation, 1997, Oct-21, Volume: 96, Issue:8

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Cattle; Cell Division; Culture Media; Dipyridamole; DNA Replication; Enzyme Inhibitors; Fibroblasts; Heart; Male; Myocardium; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tubercidin; Xanthines

1997
Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:3

    Topics: Adenine; Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Heart; In Vitro Techniques; Kinetics; Male; Myocardium; Purines; Rats; Rats, Sprague-Dawley; Ribose; Tubercidin; Uridine

1998
Dual cardiac microdialysis to assess drug-induced changes in interstitial purine metabolites: adenosine deaminase inhibition versus adenosine kinase inhibition.
    Cardiovascular research, 1998, Volume: 37, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Chromatography, High Pressure Liquid; Extracellular Space; Hypoxanthine; Inosine; Male; Microdialysis; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Tubercidin

1998
Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex.
    European journal of pharmacology, 1998, Mar-05, Volume: 344, Issue:2-3

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cerebral Cortex; Deoxyadenosines; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Pentostatin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tubercidin

1998
Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP.
    Biological chemistry, 1998, Volume: 379, Issue:11

    Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Monophosphate; Animals; Autophagy; Cells, Cultured; Enzyme Inhibitors; Liver; Male; Pentostatin; Phosphorylation; Rats; Rats, Wistar; Tubercidin

1998
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
    European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3

    Topics: Adenosine Kinase; Animals; Anti-Bacterial Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Morphine; Narcotics; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Streptozocin; Theophylline; Tubercidin

1999
Quantification of extracellular and intracellular adenosine production: understanding the transmembranous concentration gradient.
    Circulation, 1999, Apr-20, Volume: 99, Issue:15

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Biological Transport; Bradykinin; Coronary Circulation; Cytosol; Depression, Chemical; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Extracellular Space; Guinea Pigs; Heart; Models, Biological; Myocardium; Osmolar Concentration; Oxygen; Oxygen Consumption; Piperazines; Thioinosine; Tubercidin

1999
Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Adenosine; Adenosine Kinase; Animals; Anticonvulsants; Cattle; Cells, Cultured; Deoxyadenosines; Electroshock; Endothelium, Vascular; Enzyme Inhibitors; Male; Microcirculation; Motor Activity; Neocortex; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Strains; Recombinant Proteins; Seizures; Structure-Activity Relationship; Tubercidin

1999
Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats.
    Neuroscience letters, 1999, May-07, Volume: 266, Issue:2

    Topics: Adenosine; Adenosine Kinase; Animals; Corpus Striatum; Enzyme Inhibitors; Kainic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Tubercidin

1999
A(2B) receptors mediate antimitogenesis in vascular smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:1 Pt 2

    Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticoagulants; Antihypertensive Agents; Aorta, Abdominal; Becaplermin; Cell Division; Dinucleoside Phosphates; Enzyme Inhibitors; Hyperplasia; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Phenethylamines; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Thymidine; Tritium; Tubercidin; Vasodilator Agents; Xanthines

2000
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
    Journal of molecular biology, 2000, Feb-18, Volume: 296, Issue:2

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Amino Acid Sequence; Animals; Anions; Antiprotozoal Agents; Apoenzymes; Base Sequence; Binding Sites; Catalysis; Conserved Sequence; Crystallography, X-Ray; Humans; Hydrogen Bonding; Magnesium; Models, Molecular; Molecular Sequence Data; Prodrugs; Protein Structure, Secondary; Protein Structure, Tertiary; Toxoplasma; Tubercidin; Water

2000
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
    Journal of molecular biology, 2000, May-19, Volume: 298, Issue:5

    Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Amino Acid Sequence; Animals; Anions; Antiprotozoal Agents; Apoenzymes; Binding Sites; Catalysis; Conserved Sequence; Crystallography, X-Ray; Humans; Hydrogen Bonding; Magnesium; Models, Molecular; Molecular Sequence Data; Prodrugs; Protein Structure, Secondary; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity; Toxoplasma; Tubercidin; Water

2000
Adenosine- and 2-chloro-adenosine-induced cytopathic effects on myoblastic cells and myotubes: involvement of different intracellular mechanisms.
    Neuromuscular disorders : NMD, 2000, Volume: 10, Issue:6

    Topics: 2-Chloroadenosine; Acetylcysteine; Actin Cytoskeleton; Adenosine; Adenosine Kinase; Animals; Apoptosis; Cell Adhesion; Cell Line; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Homocysteine; Intracellular Fluid; Mice; Microscopy, Electron, Scanning; Muscle, Skeletal; Purinergic P1 Receptor Antagonists; Reactive Oxygen Species; Thioinosine; Tubercidin

2000
Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: Adenosine Kinase; Animals; Anticonvulsants; Electroshock; Enzyme Inhibitors; Humans; Male; Rats; Recombinant Proteins; Seizures; Structure-Activity Relationship; Tubercidin

2000
Adenosine kinase inhibitors. 2. Synthesis, enzyme inhibition, and antiseizure activity of diaryltubercidin analogues.
    Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15

    Topics: Adenosine Kinase; Animals; Anticonvulsants; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Rats; Recombinant Proteins; Seizures; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tubercidin

2000
Effect of adenosine kinase, adenosine deaminase and transport inhibitors on striatal dopamine and stereotypy after methamphetamine administration.
    Neuropharmacology, 2000, Aug-23, Volume: 39, Issue:11

    Topics: Adenosine Deaminase; Adenosine Kinase; Animals; Corpus Striatum; Dilazep; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Male; Methamphetamine; Pentostatin; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Tubercidin

2000
Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart.
    Cardiovascular research, 2001, Volume: 52, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Enzyme Inhibitors; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Tubercidin

2001
Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors.
    British journal of pharmacology, 2001, Volume: 134, Issue:5

    Topics: Adenine Nucleotides; Adenosine; Adenosine Kinase; Animals; Carrier Proteins; Deoxyadenosines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Equilibrative Nucleoside Transport Proteins; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Gene Expression; Membrane Proteins; Membrane Transport Proteins; Nucleoside Transport Proteins; Thioinosine; Tritium; Tubercidin; Tumor Cells, Cultured

2001
The effect of adenosine metabolism inhibition and nucleotide precursor supply on adenosine production in human heart endothelial cells.
    Advances in experimental medicine and biology, 2000, Volume: 486

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Triphosphate; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nucleotides; Pentostatin; Phosphates; Ribose; Tubercidin

2000
The cytotoxic effect of purine riboside on COS-7 cells.
    Advances in experimental medicine and biology, 2000, Volume: 486

    Topics: 5'-Nucleotidase; Adenosine Kinase; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Survival; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Humans; Kinetics; Purine Nucleosides; Ribonucleosides; Tubercidin

2000
Effects of an adenosine kinase inhibitor and an adenosine deaminase inhibitor on accumulation of extracellular adenosine by equine articular chondrocytes.
    American journal of veterinary research, 2002, Volume: 63, Issue:11

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cartilage, Articular; Chondrocytes; Enzyme Inhibitors; Horses; Lipopolysaccharides; Nitric Oxide; Nitrites; Tubercidin

2002
Quantitative structure-activity relationship study of 5-iodo- and diaryl-analogues of tubercidin: inhibitors of adenosine kinase.
    Journal of enzyme inhibition and medicinal chemistry, 2003, Volume: 18, Issue:5

    Topics: Adenosine Kinase; Drug Design; Iodine; Molecular Structure; Quantitative Structure-Activity Relationship; Tubercidin

2003
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jan-21, Volume: 24, Issue:3

    Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Brain; Disease Models, Animal; Disease Progression; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Neurons; Tubercidin; Xanthines

2004
Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism.
    Osteoarthritis and cartilage, 2005, Volume: 13, Issue:3

    Topics: Adenosine; Adenosine Kinase; Animals; Cartilage, Articular; Culture Media, Conditioned; Dinoprostone; Enzyme Inhibitors; Glycosaminoglycans; Horses; Interleukin-1; Lipopolysaccharides; Matrix Metalloproteinase 3; Nitric Oxide; Tissue Culture Techniques; Tubercidin

2005
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
    Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 10

    Topics: Adenosine Kinase; Animals; Astrocytes; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Locomotion; Male; Mice; Mice, Transgenic; Neurons; Transgenes; Tubercidin; Up-Regulation

2005
Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues.
    Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20

    Topics: Adenosine; Adenosine Kinase; Administration, Oral; Analgesics; Animals; Area Under Curve; Biological Availability; Callithrix; Dogs; Humans; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tubercidin

2005
The role of adenosine in chondrocyte death in murine osteoarthritis and in a murine chondrocyte cell line.
    Osteoarthritis and cartilage, 2006, Volume: 14, Issue:5

    Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Apoptosis; Cartilage, Articular; Cell Death; Cell Line; Chondrocytes; DNA Fragmentation; Enzyme Inhibitors; Homocysteine; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Tubercidin

2006
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:1

    Topics: Adenosine; Adenosine Kinase; Animals; Brain Ischemia; Cell Death; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Functional Laterality; Hippocampus; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Promoter Regions, Genetic; Pyramidal Cells; Receptor, Adenosine A1; Tubercidin; Ubiquitin

2007
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 59, Issue:1

    Topics: Adenosine Kinase; Antitubercular Agents; Humans; Ligands; Mycobacterium tuberculosis; Structure-Activity Relationship; Substrate Specificity; Tubercidin

2007
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
    Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

    Topics: Adenosine Kinase; Animals; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Morpholines; Protein Binding; Protein Conformation; Pyrimidines; Toxoplasma; Tubercidin

2006
Biochemical and biological properties of 5-bromotubercidin: differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis.
    Bioorganic & medicinal chemistry, 2008, Feb-01, Volume: 16, Issue:3

    Topics: Acids; Adenosine Kinase; Animals; Antiviral Agents; Cell Line; Cell Proliferation; DNA; Hydrogen-Ion Concentration; Kinetics; Liver; Mice; Molecular Structure; Protein Kinase Inhibitors; Rabbits; RNA, Viral; Solubility; Structure-Activity Relationship; Tubercidin

2008
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
    The journal of sexual medicine, 2008, Volume: 5, Issue:5

    Topics: Acetylcholine; Adenosine; Adenosine Kinase; Animals; Diabetes Mellitus, Type 2; Dipyridamole; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Male; Mice; Mice, Mutant Strains; Mice, Obese; Muscle Contraction; Muscle, Smooth; Nitroprusside; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Tubercidin; Vasoconstrictor Agents; Vasodilator Agents

2008
A small molecule inhibitor of alpha4 integrin-dependent cell migration.
    Bioorganic & medicinal chemistry, 2009, Feb-01, Volume: 17, Issue:3

    Topics: Actinin; Adenosine Kinase; Aniline Compounds; Animals; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Humans; Integrin alpha4; Jurkat Cells; RNA Interference; Signal Transduction; Small Molecule Libraries; Tubercidin

2009
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.
    Neuropharmacology, 2009, Volume: 56, Issue:2

    Topics: Adenosine; Adenosine Kinase; Animals; Animals, Newborn; Astrocytes; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Hippocampus; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Seizures; Synapses; Theophylline; Time Factors; Tubercidin

2009
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin

2010
Adenosine A1 receptor blockage mediates theophylline-associated seizures.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Behavior, Animal; Body Temperature; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Hyperthermia, Induced; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Lew; Seizures; Theophylline; Tubercidin

2010
Deciphering ligand dependent degree of binding site closure and its implication in inhibitor design: A modeling study on human adenosine kinase.
    Journal of molecular graphics & modelling, 2010, Feb-26, Volume: 28, Issue:6

    Topics: Adenosine Kinase; Binding Sites; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Protein Conformation; Structural Homology, Protein; Structure-Activity Relationship; Tubercidin; User-Computer Interface

2010
Molecular characterization of Chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics.
    BMC biochemistry, 2011, May-17, Volume: 12

    Topics: Adenosine Kinase; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cricetinae; Cricetulus; Exons; Formycins; Gene Expression Regulation; Humans; Mice; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Protein Isoforms; Protein Structure, Tertiary; Rats; Tubercidin

2011
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
    Journal of medicinal chemistry, 2011, Aug-11, Volume: 54, Issue:15

    Topics: Adenosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cytostatic Agents; Humans; Mice; RNA Polymerase II; Tubercidin

2011
Inhibition of Adenosine Kinase Attenuates Acute Lung Injury.
    Critical care medicine, 2016, Volume: 44, Issue:4

    Topics: Acute Lung Injury; Adenosine Kinase; Animals; B-Lymphocytes; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Lipopolysaccharides; Lung; Mice; Pneumonia; Prospective Studies; Tubercidin

2016
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
    Journal of medicinal chemistry, 2016, 07-28, Volume: 59, Issue:14

    Topics: Adenosine Kinase; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Conformation; Protein Kinase Inhibitors; Structure-Activity Relationship; Tubercidin

2016
Epigenetic determinants of space radiation-induced cognitive dysfunction.
    Scientific reports, 2017, 02-21, Volume: 7

    Topics: 5-Methylcytosine; Adenosine Kinase; Animals; Behavior, Animal; Brain; Dioxygenases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Epigenomics; Hippocampus; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Tubercidin; Whole-Body Irradiation

2017
Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice.
    Epilepsia, 2019, Volume: 60, Issue:4

    Topics: Adenosine Kinase; Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Epilepsy; Male; Mice; Mice, Inbred C57BL; Tubercidin

2019
Suppression of phrenic nerve activity as a potential predictor of imminent sudden unexpected death in epilepsy (SUDEP).
    Neuropharmacology, 2021, 02-15, Volume: 184

    Topics: Adenosine Kinase; Animals; Kainic Acid; Male; Phrenic Nerve; Predictive Value of Tests; Rats; Rats, Wistar; Seizures; Sudden Unexpected Death in Epilepsy; Tubercidin

2021
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