tubastatin-a has been researched along with ebselen* in 1 studies
1 other study(ies) available for tubastatin-a and ebselen
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease.
A series of hybrids containing the pharmacophores of the histone deacetylase (HDAC) inhibitor, SAHA, and the antioxidant ebselen were designed and synthesized as multi-target-directed ligands against Alzheimer's disease. An in vitro assay indicated that some of these molecules exhibit potent HDAC inhibitory activity and ebselen-related pharmacological effects. Specifically, the optimal compound 7f was found to be a potent HDAC inhibitor (IC Topics: Alzheimer Disease; Animals; Azoles; Biomimetic Materials; Drug Design; Free Radical Scavengers; Glutathione Peroxidase; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Isoindoles; Organoselenium Compounds; PC12 Cells; Rats; Vorinostat | 2018 |