tryptophyl-histidine and ferulic-acid

tryptophyl-histidine has been researched along with ferulic-acid* in 1 studies

Other Studies

1 other study(ies) available for tryptophyl-histidine and ferulic-acid

ArticleYear
Ferulic acid enhances the vasorelaxant effect of epigallocatechin gallate in tumor necrosis factor-alpha-induced inflammatory rat aorta.
    The Journal of nutritional biochemistry, 2014, Volume: 25, Issue:7

    Previously, we demonstrated synergistic enhancement of vasorelaxation by combination treatment with Trp-His and epigallocatechin gallate (EGCg) in intact rat aorta. The aim of the present study was to determine whether this vasorelaxant synergy could be recapitulated in tumor necrosis factor-alpha (TNF-α)-induced inflammatory rat aorta, and to determine the extent of its modulation by anti-inflammatory phenolic acids. Synergistic enhancement of vasorelaxation in rat aorta by Trp-His and EGCg was significantly attenuated in the presence of TNF-α, an effect that was reversed by the addition of ferulic acid (FA, 250 μM). Moreover, FA markedly enhanced EGCg-induced vasorelaxation, but not Trp-His-induced vasorelaxation, in TNF-α-treated aorta. Structure-activity analysis showed that the unsaturated 2-propenoic moiety and the methoxy group of FA were important for the enhancement of vasorelaxation by EGCg. The stimulation of EGCg-induced vasorelaxation by FA was antagonized by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine acetate, while FA enhanced vasorelaxant properties of the endothelial nitric oxide (NO) synthase activator acetylcholine in TNF-α-treated inflammatory aorta. Moreover, the EGCg-stimulated NO production was also enhanced by FA in TNF-α-treated aorta. These data indicate that stimulation of NO production by FA enhances the vasorelaxant properties of EGCg in TNF-α-induced inflammatory aorta.

    Topics: Animals; Aorta; Arginine; Catechin; Coumaric Acids; Dipeptides; Drug Synergism; Male; Rats, Sprague-Dawley; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Vasodilation

2014