tryptophyl-histidine and aspartyltyrosine

tryptophyl-histidine has been researched along with aspartyltyrosine* in 1 studies

Other Studies

1 other study(ies) available for tryptophyl-histidine and aspartyltyrosine

Article	Year
Heptapeptide mimic of ohmefentanyl binding in the discontinuous mu-opiod receptor. Organic letters, 2005, Jul-07, Volume: 7, Issue:14 [reaction: see text] Ohmefentanyl binds to the rat mu-opiod receptor via two dipeptide sequences (Trp-His and Asp-Tyr) that are separated by 170 residues. A turn-inducing tripeptide, Pro-Aib-Aib, holds the dipeptides in a conformation that binds the narcotic (K(b) = 7.1 x 10(4) M(-)(1)) in THF. Binding is specific for ohmefentanyl over morphine and is accompanied by a conformational change in the heptapeptide host. Control experiments with a Gly-Gly-Gly tripeptide linking the dipeptides show no evidence of binding. Topics: Amino Acid Sequence; Animals; Dipeptides; Fentanyl; Molecular Mimicry; Molecular Structure; Morphine; Peptides; Rats; Receptors, Opioid, mu	2005

Article

Year

Heptapeptide mimic of ohmefentanyl binding in the discontinuous mu-opiod receptor.

Organic letters, 2005, Jul-07, Volume: 7, Issue:14

[reaction: see text] Ohmefentanyl binds to the rat mu-opiod receptor via two dipeptide sequences (Trp-His and Asp-Tyr) that are separated by 170 residues. A turn-inducing tripeptide, Pro-Aib-Aib, holds the dipeptides in a conformation that binds the narcotic (K(b) = 7.1 x 10(4) M(-)(1)) in THF. Binding is specific for ohmefentanyl over morphine and is accompanied by a conformational change in the heptapeptide host. Control experiments with a Gly-Gly-Gly tripeptide linking the dipeptides show no evidence of binding.

Topics: Amino Acid Sequence; Animals; Dipeptides; Fentanyl; Molecular Mimicry; Molecular Structure; Morphine; Peptides; Rats; Receptors, Opioid, mu

2005