tryptophan methyl ester has been researched along with tryptophan in 106 studies
| Studies (tryptophan methyl ester) | Trials (tryptophan methyl ester) | Recent Studies (post-2010) (tryptophan methyl ester) | Studies (tryptophan) | Trials (tryptophan) | Recent Studies (post-2010) (tryptophan) |
|---|---|---|---|---|---|
| 115 | 1 | 35 | 32,762 | 936 | 7,183 |
| Protein | Taxonomy | tryptophan methyl ester (IC50) | tryptophan (IC50) |
|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | 2.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (19.81) | 18.7374 |
| 1990's | 15 (14.15) | 18.2507 |
| 2000's | 34 (32.08) | 29.6817 |
| 2010's | 34 (32.08) | 24.3611 |
| 2020's | 2 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Diksic, M; Nagahiro, S; Riml, H; Yamamoto, YL | 1 |
| Dillon, D; Macleod, H; Stadler, D | 1 |
| Gollnick, P; Horn, V; Yanofsky, C | 1 |
| Bogitsh, BJ; Davenport, GR | 1 |
| Bender, SL; Brzovic, P; Dunn, MF; Phillips, RS | 1 |
| Floss, HG; Frenzel, T; Zhou, P | 1 |
| Diksic, M; Nagahiro, S; Sourkes, TL | 1 |
| Beale, JM; Floss, HG; Rohr, J | 1 |
| Kuhn, AO; Lederer, M; Sinibaldi, M | 1 |
| Ahmed, S; Bisby, RH; Cundall, RB; Thomas, EW | 1 |
| Bandow, H; Iizuka, T; Ishimura, Y; Makino, R; Sakaguchi, K; Uchida, K | 1 |
| Baker, ME; Fanestil, DD; Morris, CS | 1 |
| Erge, D; Gröger, D; Schumann, B | 1 |
| Bridger, WH; Broderick, PA | 1 |
| Baker, ME; Kimlinger, WR | 1 |
| Lacko, L; Wittke, B | 1 |
| Baker, ME; Fanestil, DD; Vaughn, DA | 1 |
| Diksic, M; Mzengeza, S; Venkatachalam, TK | 1 |
| Barjavel, MJ; Bhargava, HN; Thorat, SN | 1 |
| Baker, ME; Brtko, J; Knopp, J | 1 |
| Beaudet, A; Cohen, Z; Diksic, M; Hamel, E; Takada, A; Tsuiki, K | 1 |
| Fanali, S; Kilár, F | 1 |
| Attwood, JT; Bondarev, I; Brown, C; Conway, SJ; Marshall, B; Mellor, AL; Munn, DH; Zhou, M | 1 |
| Gura, T | 1 |
| Attwood, JT; Bondarev, I; Mellor, AL; Munn, DH; Pashine, A; Shafizadeh, E | 1 |
| Chugani, DC; Muzik, O | 1 |
| Chao, W; Dongmei, H; Ming, Z; Shiqi, P | 1 |
| Ganesan, A; Wang, H | 1 |
| Khanna, P; Schuman Jorns, M | 2 |
| Asano, E; Behen, M; Chakraborty, PK; Chugani, DC; Chugani, HT; Janisse, J; Mangner, TJ; Muzik, O; Rothermel, R | 1 |
| Blier, P; Diksic, M; Okazawa, H; Yamane, F | 1 |
| Alexander, IE; Earl, JW; Logan, GJ; Rowe, PB; Smyth, CM; Smythe, JA; Zaikina, I | 1 |
| Baran, PS; Corey, EJ | 1 |
| Alsarraj, M; Antonia, SJ; Cantor, A; Dessureault, S; Extermann, M; Friberg, M; Jennings, R; Mellor, AL; Munn, DH | 1 |
| Cook, JM; Liao, X; Yu, J | 1 |
| Chugani, DC; Chugani, HT | 1 |
| CLARK, PF; ELVEHJEM, CA; RASMUSSEN, AF; WEAVER, RW | 1 |
| BOLLAG, W; KOSZEWSKI, BJ | 1 |
| KESSLER, B | 1 |
| LESTER, G | 2 |
| KATZ, E; SIVAK, A | 1 |
| TURNOCK, G; WILD, DG | 1 |
| FLOSS, HG; GROEGER, D | 1 |
| NEWTON, WA; SNELL, EE | 1 |
| FLEISHER, GA; ISHIMARU, T; RAMACHANDER, G; ZELLER, EA; ZELLER, V | 1 |
| Asano, E; Chakraborty, PK; Chugani, DC; Chugani, HT; Juhász, C; Mangner, TJ; Muzik, O; Padhye, UN; Shah, A; Sood, S | 1 |
| Boyd, CA; Hara, T; Katsuki, T; Kudo, Y; Ohama, K; Redman, CW; Sargent, IL; Spyropoulou, I; Takikawa, O | 1 |
| Bellocchio, S; Bozza, S; Fallarino, F; Montagnoli, C; Mosci, P; Pitzurra, L; Puccetti, P; Romani, L; Vacca, C; Zelante, T | 1 |
| Chrastil, J; Dou, H; Gendelman, HE; Heilman, D; Knipe, B; Munn, DH; Persidsky, Y; Poluektova, L; Potula, R; Takikawa, O | 1 |
| Elek, J; Heyden, YV; Iványi, T; Lázár, I; Mangelings, D | 1 |
| Bertoldi, M; Cellini, B; Maras, B; Voltattorni, CB | 1 |
| Matthijs, N; Vander Heyden, Y | 1 |
| Himeno, K; Hisaeda, H; Tetsutani, K; To, H; Torii, M | 1 |
| Benkelfat, C; Diksic, M; Leyton, M; Morais, JA; Rosa-Neto, P; Sakai, Y | 1 |
| Germenis, AE; Karanikas, V; Zamanakou, M | 1 |
| Behen, M; Chugani, HT; Helder, E; Ho, A; Juhász, C; Maqbool, M; Muzik, O; Perry, J; Rothermel, RD | 1 |
| Ames, MM; Buhrow, SA; Jia, L; Munn, DH; Noker, PE; Page, JG; Reid, JM; Schweikart, K; Tomaszewski, J | 1 |
| PILGRIM, FJ; SNYDER, HR | 1 |
| Achiwa, Y; Hasegawa, K; Kato, T; Kurahashi, H; Nishizawa, H; Saito, K; Suzuki, M; Udagawa, Y | 1 |
| Aubé, M; Diksic, M; Dobson, C; Hamel, E; Sakai, Y | 1 |
| Akhtari, M; Bragin, A; Brenker, F; Cohen, M; Engel, J; Lynch, MD; Moats, R; Vinters, HV | 1 |
| Du, C; Guan, Q; Jevnikar, AM; Mellor, AL; Mohib, K; Sun, H; Wang, S | 1 |
| Andersen, OS; Greathouse, DV; Koeppe, RE; Sun, H | 1 |
| Dahlke, MH; Eggenhofer, E; Geissler, EK; Kaspar, H; Lang, SA; Piso, P; Popp, FC; Renner, P; Schlitt, HJ; Slowik, P | 1 |
| Metcalf, JL; Osborne, AS; Phillips, RS; Som, P | 1 |
| Akiyama, Y; Hara, N; Miyazaki, T; Moritake, K; Osago, H; Shibata, T; Tsuchiya, M; Yamada, K | 1 |
| Chandra, H; Chaturvedi, S; Chuttani, K; Mishra, AK; Shukla, G; Sinha, D; Tiwari, AK | 1 |
| Andersen, MH; Sørensen, RB; thor Straten, P | 1 |
| Arthur, JW; Austin, CJ; Ball, HJ; Becker, K; Hunt, NH; Maghzal, GJ; Mailu, BM; Rahlfs, S; Sanchez-Perez, A; Stocker, R; Yuasa, HJ; Zocher, K | 1 |
| Austin, CJ; Ball, HJ; Hunt, NH; Yuasa, HJ | 1 |
| Kaledin, VI; Lushnikova, EL; Nikolin, VP; Popova, NA; Vasil'eva, ED | 1 |
| Brew, BJ; Chen, Y; Guillemin, GJ | 1 |
| Boor, PP; Jonge, Sd; Kwekkeboom, J; Mancham, S; Metselaar, HJ; van der Laan, LJ | 1 |
| Benkelfat, C; Booij, L; Diksic, M; Gravel, P; Leyton, M; Lopez De Lara, C; Turecki, G | 1 |
| AbdelRahman, YM; Aiyar, AA; Beatty, WL; Belland, RJ; Ibana, JA; Nagamatsu, T; Quayle, AJ; Schust, DJ; Tate, DJ; Zea, AH | 1 |
| Chakraborty, PK; Chugani, HT; Kumar, A; Tiwari, VN | 1 |
| Alam, S; Antus, S; Duddeck, H; Hasan, M; Kenéz, A; Khan, KM; Khan, N; Kurtán, T; Pescitelli, G; Rashid, N | 1 |
| Deeks, SG; Dunham, RM; Franchini, G; Gordon, SN; Huang, Y; Lifson, J; McCune, JM; Piatak, M; Vaccari, M | 1 |
| Baydemir, G; Denizli, A; Ergün, B; Perçin, I | 1 |
| Buth, A; Chugani, DC; Chugani, HT; Juhász, C; Kupsky, WJ; Mittal, S; Shah, AK | 1 |
| Choi, KM; Jung, ID; Kang, YK; Kim, B; Lee, MG; Park, YM; Yim, HS | 1 |
| Asano, E; Chugani, HT; Govindan, R; Kumar, A; Luat, AF; Pawlik, K | 1 |
| Fort, PE; Green, KM; Nagaraj, RH; Nahomi, RB; Palmer, A | 1 |
| Wang, C; Wang, H | 1 |
| Boesen, EI; Gardner, JR; Ghaffari, A; Harbarger, R; Kitamura, E; Mellor, A; Merchen, TD; Nahman, NS; Podolsky, R; Pollock, DM | 1 |
| Ball, HJ; Mowat, CG; Pantouris, G; Serys, M; Yuasa, HJ | 1 |
| Barger, GR; Chakraborty, PK; Juhász, C; Kamson, DO; Lee, TJ; Mittal, S; Muzik, O; Robinette, NL; Snyder, M; Varadarajan, K | 1 |
| Aparício, JL; Duhalde Vega, M; Retegui, LA | 1 |
| Agardh, H; Assinger, A; Bäck, M; Baumgartner, R; Berg, M; Gisterå, A; Hansson, GK; Ketelhuth, DF; Laguna-Fernandez, A; Ovchinnikova, O; Pirault, J; Polyzos, KA | 1 |
| Bellina, B; Kresin, VV; Merthe, DJ | 1 |
| Ding, G; Sun, W; Wei, L; Zhang, L | 1 |
| Choi, EY; Lee, YK; Shin, DM; Shin, JH; Shon, WJ | 1 |
| Bieback, K; Ho, AD; Hong, J; Hueckelhoven, A; Kleist, C; Schmitt, A; Schmitt, M; Tabarkiewicz, J; Wang, L; Wuchter, P | 1 |
| Balzarini, J; Camarasa, MJ; Flores, A; Leyssen, P; Liekens, S; Martínez-Gualda, B; Mirabelli, C; Neyts, J; Noppen, S; Quesada, E; Rivero-Buceta, E; San-Félix, A; Schols, D; Sun, L | 1 |
| Fan, D; Lu, Y; Xiong, D; Yang, Y; Ye, Z; Zhang, L; Zhang, Q; Zhang, X; Zhang, Y | 1 |
| Fei, H; Feng, H; Giglio, BC; He, L; Li, Z; Lu, H; Wang, H; Wang, M; Wu, Z | 1 |
| Baik, SK; Choi, SI; Eom, YW; Lee, JI; Oh, JE; Shim, KY | 1 |
| Hwang, WB; Kim, DJ; Lee, EJ; Lee, JM; Park, JH | 1 |
| Ahlstedt, J; Ceberg, C; Chakwizira, A; Nittby Redebrandt, H | 1 |
| Antoni, G; Eriksson, J; Gustavsson, SÅ; Nordeman, P; Wilking, H; Yngve, U | 1 |
| Feng, Y; Feng, Z; Guo, J; Guo, M; Jia, H; Ren, W; Song, X; Tian, Z; Wang, H; Wang, M; Wei, T; Zhao, J; Zhao, T | 1 |
| Argolo, DS; Arruda, MR; Bispo-da-Silva, A; Costa, MFD; Costa, SL; El-Bachá, RS; Grangeiro, MS; Jesus, EEV; Jesus, LB; Pinheiro, AM; Santos, AB; Santos, RGD | 1 |
| Dehpour, AR; Faghir-Ghanesefat, H; Guillemin, GJ; Mani, AR; Rashidian, A; Shayesteh, S; Tavangar, SM | 1 |
| Eleftheriadis, T; Filippidis, G; Liakopoulos, V; Pissas, G; Stefanidis, I | 1 |
2 review(s) available for tryptophan methyl ester and tryptophan
| Article | Year |
|---|---|
Alpha[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism.
Topics: Brain; Carbon Radioisotopes; Humans; Kynurenine; Serotonin; Tomography, Emission-Computed; Tryptophan | 2000 |
Tumor immune escape mediated by indoleamine 2,3-dioxygenase.
Topics: Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; T-Lymphocytes; Tryptophan; Tumor Escape | 2007 |
1 trial(s) available for tryptophan methyl ester and tryptophan
| Article | Year |
|---|---|
Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis.
Topics: Adult; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebral Cortex; Feedback, Physiological; Female; Humans; Male; Middle Aged; Migraine Disorders; Pain Measurement; Positron-Emission Tomography; Serotonin; Serotonin Receptor Agonists; Sumatriptan; Synaptic Transmission; Treatment Outcome; Tryptophan; Up-Regulation | 2008 |
103 other study(ies) available for tryptophan methyl ester and tryptophan
| Article | Year |
|---|---|
Non-invasive in-vivo autoradiographic method to measure axonal transport in serotoninergic neurons in the rat brain.
Topics: Animals; Autoradiography; Axonal Transport; Female; Medial Forebrain Bundle; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1990 |
Spontaneous mutation at the mtr locus of Neurospora: the spectrum of mutant types.
Topics: Aminoacridines; Cloning, Molecular; Genes, Fungal; Membrane Transport Proteins; Multigene Family; Mutation; Neurospora; Nitrogen Mustard Compounds; Nitrosoguanidines; Restriction Mapping; Tryptophan | 1991 |
Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli.
Topics: Amino Acid Transport Systems; Biological Transport; Carbon; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genotype; Indoles; Lac Operon; Membrane Transport Proteins; Mutation; Operon; Protein Biosynthesis; Recombination, Genetic; Saccharomyces cerevisiae Proteins; Tryptophan; Tryptophanase | 1991 |
The in vitro effects of various lysosomotropic agents on the gut of Schistosoma mansoni schistosomula.
Topics: Acridine Orange; Alanine; Amino Acids; Ammonium Chloride; Animals; Chloroquine; Dipeptides; Esters; Hydrogen-Ion Concentration; Leucine; Microscopy, Electron; Microscopy, Fluorescence; Schistosoma mansoni; Tryptophan | 1991 |
Mechanism of binding of substrate analogues to tryptophan indole-lyase: studies using rapid-scanning and single-wavelength stopped-flow spectrophotometry.
Topics: Alanine; Aminobutyrates; Bacterial Proteins; Escherichia coli; Kinetics; Oxindoles; Protein Binding; Spectrophotometry; Substrate Specificity; Tryptophan; Tryptophanase | 1990 |
Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase.
Topics: Anti-Bacterial Agents; Kinetics; Methyltransferases; Streptomyces; Substrate Specificity; Thiostrepton; Tryptophan | 1990 |
Biological model for the in vivo measurement of rate of serotonin synthesis in the brain.
Topics: Animals; Autoradiography; Brain; Female; Models, Neurological; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1990 |
Urdamycins, new angucycline antibiotics from Streptomyces fradiae. IV. Biosynthetic studies of urdamycins A-D.
Topics: Acetates; Aminoglycosides; Anthraquinones; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Fermentation; Glucose; Glycerol; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Streptomyces; Tryptophan; Tyrosine | 1989 |
Adsorption chromatography on cellulose. IV. Separation of D- and L-tryptophan and D- and L-methyltryptophan on cellulose with aqueous solvents.
Topics: Chemical Phenomena; Chemistry; Chromatography, Paper; Solvents; Tryptophan | 1989 |
Free radical reactions with alpha-tocopherol and N-stearoyl tryptophan methyl ester in micellar solutions.
Topics: Free Radicals; Micelles; Pulse Radiolysis; Tryptophan; Vitamin E | 1986 |
Infrared spectra of carbon monoxide complexes of indoleamine 2,3-dioxygenase and L-tryptophan 2,3-dioxygenases. Effects of substrates on the CO-stretching frequencies.
Topics: Animals; Carbon Monoxide; Intestine, Small; Liver; Male; Oxygenases; Pseudomonas; Rabbits; Rats; Rats, Inbred Strains; Skatole; Spectrophotometry, Infrared; Tryptophan; Tryptophan Oxygenase | 1985 |
Binding of the chymotrypsin substrate, tryptophan methyl ester, by rat alpha-fetoprotein.
Topics: alpha-Fetoproteins; Animals; Chymotrypsin; Estrone; Kinetics; Protein Binding; Rats; Tryptophan | 1980 |
Influence of tryptophan and related compounds on ergot alkaloid formation in Claviceps purpurea (FR.) Tul.
Topics: Chemical Phenomena; Chemistry; Claviceps; Culture Media; Ergolines; Ergot Alkaloids; Mutation; Phosphates; Stereoisomerism; Tryptophan | 1984 |
A comparative study of the effect of L-tryptophan and its acetylated derivative N-acetyl-L-tryptophan on rat muricidal behavior.
Topics: Aggression; Agonistic Behavior; Animals; Dose-Response Relationship, Drug; Humans; Male; Rats; Reaction Time; Tryptophan | 1984 |
Protease substrates inhibit binding of 3H-R5020 to the G-fragment in chick oviduct cytosol.
Topics: Animals; Arginine; Cytosol; Kinetics; Molecular Weight; Norpregnadienes; Oviducts; Promegestone; Receptors, Progesterone; Time Factors; Tosylarginine Methyl Ester; Tryptophan | 1982 |
The competitive inhibition of glucose transport in human erythrocytes by compounds of different structures.
Topics: Binding, Competitive; Blood Glucose; Blood Proteins; Carrier Proteins; Erythrocytes; Ethanol; Humans; In Vitro Techniques; Kinetics; Maltose; Models, Chemical; Tryptophan | 1982 |
Competitive inhibition of dexamethasone binding to the glucocorticoid receptor in HTC cells by tryptophan methyl ester.
Topics: Animals; Binding, Competitive; Cells, Cultured; Dexamethasone; Liver Neoplasms, Experimental; Rats; Receptors, Glucocorticoid; Receptors, Steroid; Tryptophan | 1980 |
Asymmetric radiosynthesis of alpha-[11C]methyl-L-tryptophan for PET studies.
Topics: Carbon Radioisotopes; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Tomography, Emission-Computed; Tryptophan | 1995 |
Enhancement of a kappa-opioid receptor agonist-induced analgesia by L-tyrosine and L-tryptophan.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Tryptophan; Tyrosine | 1994 |
Inhibition of 3,5,3'-triiodothyronine binding to its receptor in rat liver by protease inhibitors and substrates.
Topics: Animals; Liver; Male; Molecular Structure; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Protein Binding; Rats; Rats, Wistar; Receptors, Thyroid Hormone; Structure-Activity Relationship; Sulfones; Tosylarginine Methyl Ester; Tosylphenylalanyl Chloromethyl Ketone; Triiodothyronine; Tryptophan; Tyrosine | 1993 |
In vivo-synthesized radioactively labelled alpha-methyl serotonin as a selective tracer for visualization of brain serotonin neurons.
Topics: Animals; Brain; Corpus Striatum; Hippocampus; Immunohistochemistry; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains; Serotonin; Time Factors; Tryptophan | 1995 |
Separation of tryptophan-derivative enantiomers with iron-free human serum transferrin by capillary zone electrophoresis.
Topics: Alkanesulfonic Acids; Buffers; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Isoelectric Point; Morpholines; Osmolar Concentration; Stereoisomerism; Transferrin; Tryptophan | 1995 |
Prevention of allogeneic fetal rejection by tryptophan catabolism.
Topics: Animals; Enzyme Inhibitors; Female; Fetus; Genes, MHC Class I; Genes, RAG-1; H-2 Antigens; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta; Pregnancy; T-Lymphocytes; Transgenes; Trophoblasts; Tryptophan; Tryptophan Oxygenase | 1998 |
How embryos may avoid immune attack.
Topics: Animals; Embryo, Mammalian; Enzyme Inhibitors; Female; Humans; Immune Tolerance; Male; Mice; Placenta; Pregnancy; T-Lymphocytes; Trophoblasts; Tryptophan; Tryptophan Oxygenase | 1998 |
Inhibition of T cell proliferation by macrophage tryptophan catabolism.
Topics: Cell Cycle; Cell Division; Cells, Cultured; Coculture Techniques; Culture Media; DNA; G1 Phase; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocyte Activation; Macrophage Colony-Stimulating Factor; Macrophages; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 1999 |
Synthesis and analgesic activity of N,N'-dicarbonyltryptamines.
Topics: 5-Methoxytryptamine; Acylation; Analgesics; Animals; Male; Malonates; Mice; Mice, Inbred ICR; Molecular Conformation; Pain Measurement; Structure-Activity Relationship; Succinic Anhydrides; Tryptamines; Tryptophan | 2000 |
A biomimetic total synthesis of (-)-spirotryprostatin B and related studies.
Topics: Alkaloids; Aspergillus fumigatus; Cell Cycle; Cyclization; Piperazines; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Tryptophan | 2000 |
Characterization of the FAD-containing N-methyltryptophan oxidase from Escherichia coli.
Topics: Anaerobiosis; Benzoates; Binding Sites; Enzyme Stability; Escherichia coli; Escherichia coli Proteins; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Indazoles; Ligands; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Photochemistry; Recombinant Proteins; Riboflavin; Sarcosine Oxidase; Spectrophotometry; Substrate Specificity; Tryptophan | 2001 |
N-methyltryptophan oxidase from Escherichia coli: reaction kinetics with N-methyl amino acid and carbinolamine substrates.
Topics: Amines; Anaerobiosis; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Formaldehyde; Glycine; Hydrogen-Ion Concentration; Imines; Kinetics; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Reducing Agents; Sarcosine; Substrate Specificity; Thioglycolates; Tryptophan | 2001 |
Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction.
Topics: Adolescent; Autistic Disorder; Carbon Radioisotopes; Cerebellar Nuclei; Cerebral Cortex; Child; Child, Preschool; Female; Fluorodeoxyglucose F18; Glucose; Humans; Infant; Male; Radiopharmaceuticals; Spasms, Infantile; Tomography, Emission-Computed; Tryptophan; Tuberous Sclerosis | 2001 |
Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2).
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Carrier Proteins; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2001 |
HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.
Topics: B7-1 Antigen; Cell Division; Coculture Techniques; Drug Resistance, Bacterial; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-2; Lymphocytes; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tryptophan; Tryptophan Oxygenase | 2002 |
A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole --> dihydroindoloazocine cyclization.
Topics: Azocines; Indoles; Palladium; Stereoisomerism; Tryptophan | 2002 |
Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.
Topics: Animals; Cell Division; Flow Cytometry; Immune Tolerance; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2002 |
Stereospecific, enantiospecific total synthesis of the sarpagine indole alkaloids (E)16-epiaffinisine, (E)16-epinormacusine B, and dehydro-16-epiaffinisine.
Topics: Alkaloids; Indole Alkaloids; Indoles; Plants, Medicinal; Stereoisomerism; Trees; Tryptophan | 2002 |
Does serotonin have trophic effects in temporal lobe epilepsy?
Topics: Brain Stem; Cerebral Cortex; Epilepsy, Temporal Lobe; Glucose; Hippocampus; Humans; Serotonin; Thalamus; Tomography, Emission-Computed; Tryptophan | 2003 |
Influence of low tryptophan diets containing 6-methyltryptophan on oral infection with poliomyelitis virus.
Topics: Communicable Diseases; Diet; Poliomyelitis; Poliovirus; Tryptophan | 1953 |
[Experimental kidney damage with methyl-tryptophan].
Topics: Kidney; Kidney Diseases; Tryptophan | 1953 |
Effect of methyltryptophan and thiouracil upon protein and ribonucleic acid synthesis in certain higher plants.
Topics: Plants; Proteins; RNA; Thiouracil; Tryptophan | 1956 |
Repression and inhibition of indole-synthesizing activity in Neurospora crassa.
Topics: Indoles; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Tryptophan | 1961 |
Biosynthesis of the actinomycin chromophore. Influence of alpha-, 4-, 5-, and 6-methyl-DL-tryptophan on actinomycin synthesis.
Topics: Actinomyces; Dactinomycin; Tryptophan | 1962 |
Regulation of early reactions in the biosynthesis of tryptophan in Neurospora crassa.
Topics: Glycerophosphates; Indoleacetic Acids; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Tryptophan | 1963 |
Accumulation of ribonucleic acid in Escherichia coli due to the action of 5-methyl tryptophan.
Topics: Escherichia coli; RNA; RNA, Bacterial; Tryptophan | 1963 |
[ON THE INCORPORATION OF N-ALPHA-METHYL TRYPTOPHAN AND N-OMEGA-METHYL TRYPTAMINE IN ERGOT ALKALOIDS OF THE CLAVIN TYPE].
Topics: Ascomycota; Ergot Alkaloids; Fungal Proteins; Indoles; Ribonucleases; Tryptamines; Tryptophan | 1963 |
FORMATION AND INTERRELATIONSHIPS OF TRYPTOPHANASE AND TRYPTOPHAN SYNTHETASES IN ESCHERICHIA COLI.
Topics: Culture Media; Escherichia coli; Glycerophosphates; Hydro-Lyases; Indoles; Lyases; Neutralization Tests; Pharmacology; Research; Tryptophan; Tryptophan Synthase; Tryptophanase | 1965 |
OPHIDIAN L-AMINO ACID OXIDASE. THE NATURE OF THE ENZYME-SUBSTRATE COMPLEXES.
Topics: Alanine; Amino Acid Oxidoreductases; Amino Acids; Animals; Biochemical Phenomena; Biochemistry; Catalysis; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Glycine; Hydroquinones; Kinetics; L-Amino Acid Oxidase; Phenylalanine; Research; Snakes; Tryptophan; Venoms | 1965 |
Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery.
Topics: Adolescent; Adult; Age Factors; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Male; Neocortex; Quinolinic Acid; Reoperation; Tomography, Emission-Computed; Treatment Failure; Tryptophan | 2004 |
Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta.
Topics: Antiviral Agents; Blastocyst; Cell Division; Culture Techniques; Extraembryonic Membranes; Female; Gene Expression Regulation, Developmental; Humans; Immunohistochemistry; Interferon-gamma; Leukocytes, Mononuclear; Lymphocyte Activation; Macrophages; Maternal-Fetal Exchange; Placenta; Pregnancy; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2004 |
A crucial role for tryptophan catabolism at the host/Candida albicans interface.
Topics: Animals; Candida albicans; Candidiasis; Cells, Cultured; Cytokines; Down-Regulation; Enzyme Inhibitors; Female; Gastritis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Interferon-gamma; Kidney Diseases; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Tryptophan; Tryptophan Oxygenase; Up-Regulation | 2005 |
Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.
Topics: Animals; Basal Ganglia; Blotting, Western; Brain; CD3 Complex; CD8 Antigens; CD8-Positive T-Lymphocytes; Cell Separation; Disease Models, Animal; Encephalitis, Viral; Flow Cytometry; HIV Infections; Humans; Image Processing, Computer-Assisted; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocytes; Macrophages; Male; Mice; Mice, Inbred NOD; Mice, SCID; Monocytes; T-Lymphocytes, Cytotoxic; Time Factors; Tryptophan; Up-Regulation | 2005 |
Enantioselective capillary electrophoretic separation of tryptophane- and tyrosine-methylesters in a dual system with a tetra-oxadiaza-crown-ether derivative and a cyclodextrin.
Topics: Algorithms; Buffers; Combinatorial Chemistry Techniques; Crown Compounds; Cyclodextrins; Electrolytes; Electrophoresis, Capillary; Glycine; Hydrogen-Ion Concentration; Reproducibility of Results; Spectrophotometry, Ultraviolet; Stereoisomerism; Tryptophan; Tyrosine | 2005 |
A quinonoid is an intermediate of oxidative deamination reaction catalyzed by Dopa decarboxylase.
Topics: Animals; Binding Sites; Cattle; Deamination; Dopa Decarboxylase; Molecular Conformation; Molecular Structure; Oxidation-Reduction; Oxygen Consumption; Quinones; Reproducibility of Results; Swine; Tryptophan | 2005 |
Enantiomeric impurity determination in capillary electrophoresis using a highly-sulfated cyclodextrins-based method.
Topics: Atenolol; Chlorpheniramine; Computer Simulation; Cyclodextrins; Electrophoresis, Capillary; Propranolol; Reproducibility of Results; Stereoisomerism; Tryptophan | 2006 |
Malaria parasite induces tryptophan-related immune suppression in mice.
Topics: Animals; Antimalarials; CD4-Positive T-Lymphocytes; Chloroquine; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Plasmodium yoelii; Time Factors; Tryptophan | 2007 |
Brain regional alpha-[11C]methyl-L-tryptophan trapping, used as an index of 5-HT synthesis, in healthy adults: absence of an age effect.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Carbon Radioisotopes; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Models, Statistical; Positron-Emission Tomography; Serotonin; Tryptophan | 2007 |
Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
Topics: Adolescent; Brain; Carbon Radioisotopes; Cerebral Cortex; Child; Child, Preschool; Corpus Striatum; Female; Humans; Male; Positron-Emission Tomography; Serotonin; Severity of Illness Index; Thalamus; Tourette Syndrome; Tryptophan | 2007 |
Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Calibration; Dogs; Half-Life; Injections, Intravenous; Intestinal Absorption; Male; Mice; No-Observed-Adverse-Effect Level; Protein Binding; Rats; Rats, Inbred F344; Rats, Inbred Lew; Tissue Distribution; Tryptophan | 2008 |
A synthesis of 6-methylindole and dl-6-methyltryptophan.
Topics: Tryptophan | 1948 |
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Fetus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Placenta; Pre-Eclampsia; Pregnancy; Tryptophan | 2008 |
Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy.
Topics: Acute Disease; Animals; Blood-Brain Barrier; Chronic Disease; Densitometry; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Magnetics; Magnetoencephalography; Metal Nanoparticles; Rats; Tryptophan | 2008 |
Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury.
Topics: Animals; Epithelial Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Diseases; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reperfusion Injury; Tryptophan; Up-Regulation | 2008 |
The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels.
Topics: Chromatography, Gel; Circular Dichroism; Deuterium; Gramicidin; Ion Channels; Magnetic Resonance Spectroscopy; Membrane Proteins; Methylation; Models, Molecular; Protein Structure, Tertiary; Tryptophan | 2008 |
Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate.
Topics: Animals; Dendritic Cells; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppression Therapy; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mycophenolic Acid; Rats; T-Lymphocytes, Regulatory; Tryptophan | 2008 |
Regioselective nitration of N(alpha),N(1)-bis(trifluoroacetyl)-L-tryptophan methyl ester: efficient synthesis of 2-nitro and 6-nitro-N-trifluoroacetyl-L-tryptophan methyl ester.
Topics: Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Nitrates; Tryptophan | 2008 |
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation.
Topics: Antineoplastic Agents; Drug Delivery Systems; Glioma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Tryptophan; Tumor Cells, Cultured | 2009 |
99mTc-DTPA-amino acids conjugate as specific SPECT pharmaceuticals for tumor imaging.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Humans; Mice; Mice, Inbred BALB C; Pentetic Acid; Rabbits; Radiopharmaceuticals; Technetium Tc 99m Pentetate; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tryptophan | 2009 |
Comment on "Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression".
Topics: Animals; CD8-Positive T-Lymphocytes; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Neoplasms; Rats; Tryptophan | 2009 |
Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2.
Topics: Amino Acid Sequence; Animals; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Nitric Oxide; Recombinant Proteins; Sequence Alignment; Tryptophan | 2010 |
1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan.
Topics: Animals; Anura; Chickens; Cloning, Molecular; Enzyme Inhibitors; Fishes; Humans; Hydrogen-Ion Concentration; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Mice; Stereoisomerism; Substrate Specificity; Tryptophan | 2010 |
Inhibitor of indoleamine-2,3-dioxygenase 1-methyl-D-tryptophan can stimulate the growth of immunogenic tumors.
Topics: Animals; Carcinoma, Hepatocellular; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred C3H; Muscle Neoplasms; Neoplasm Transplantation; Tryptophan | 2010 |
Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis.
Topics: Animals; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Interactions; Hydrolases; Interferon-gamma; Iron Chelating Agents; Kynurenine; L-Lactate Dehydrogenase; Mice; Microglia; Motor Neurons; Picolinic Acids; Signal Transduction; Time Factors; Tryptophan; Tryptophan Oxygenase | 2011 |
Human plasmacytoid dendritic cells induce CD8⁺ LAG-3⁺ Foxp3⁺ CTLA-4⁺ regulatory T cells that suppress allo-reactive memory T cells.
Topics: Antigens, CD; CD8 Antigens; Cells, Cultured; CTLA-4 Antigen; Dendritic Cells; Forkhead Transcription Factors; Humans; Immunologic Memory; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Isoantigens; Lymphocyte Activation; Lymphocyte Activation Gene 3 Protein; Lymphocyte Culture Test, Mixed; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Toll-Like Receptor 7; Toll-Like Receptor 9; Tryptophan | 2011 |
Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans.
Topics: Adolescent; Adult; Carbon Radioisotopes; Female; Frontal Lobe; Genotype; Humans; Male; Mental Disorders; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Psychiatric Status Rating Scales; Serotonin; Tryptophan; Tryptophan Hydroxylase | 2012 |
Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Dose-Response Relationship, Drug; Doxycycline; Epithelial Cells; HeLa Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Time Factors; Tryptophan | 2011 |
Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET).
Topics: Adolescent; Anisotropy; Carbon Radioisotopes; Cerebral Cortex; Child; Child, Preschool; Diffusion Tensor Imaging; Epilepsy; Female; Humans; Male; Positron-Emission Tomography; Statistics as Topic; Tryptophan; Tuberous Sclerosis | 2012 |
Cis-diastereoselectivity in pictet-spengler reactions of L-tryptophan and electronic circular dichroism studies.
Topics: Circular Dichroism; Cyclization; Molecular Structure; Stereoisomerism; Tryptophan | 2012 |
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
Topics: Administration, Oral; Animals; Disease Models, Animal; DNA, Viral; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macaca mulatta; Pilot Projects; Plasma; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Treatment Outcome; Tryptophan; Viral Load | 2013 |
Macroporous PHEMA-based cryogel discs for bilirubin removal.
Topics: Adsorption; Bilirubin; Chromatography, Affinity; Cryogels; Humans; Microscopy, Electron, Scanning; Polyhydroxyethyl Methacrylate; Surface Properties; Thermodynamics; Tryptophan | 2013 |
Successful surgical treatment of an inflammatory lesion associated with new-onset refractory status epilepticus.
Topics: Carbon Radioisotopes; Electroencephalography; Encephalitis; Glial Fibrillary Acidic Protein; Humans; Interleukin-1beta; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgery; Positron-Emission Tomography; Status Epilepticus; Temporal Lobe; Tryptophan | 2013 |
Effect of 1-methyl-D-tryptophan and adoptive transfer of dendritic cells on polymicrobial sepsis induced by cecal content injection.
Topics: Adoptive Transfer; Animals; Cecum; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred ICR; Sepsis; Tryptophan | 2013 |
α-[11C]-Methyl-L-tryptophan--PET in 191 patients with tuberous sclerosis complex.
Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Child; Child, Preschool; Female; Humans; Infant; Male; Positron-Emission Tomography; Radiopharmaceuticals; Tryptophan; Tuberous Sclerosis; Young Adult | 2013 |
Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells.
Topics: Apoptosis; Blotting, Western; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Glucose; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Interferon-gamma; Interleukin-1beta; Molecular Chaperones; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Reactive Oxygen Species; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tryptophan; Tumor Necrosis Factor-alpha | 2014 |
[Levo-L-methyl tryptophan induces immune imbalance at maternal-fetal interface in mice].
Topics: Animals; Female; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Mothers; Placenta; Pregnancy; Stereoisomerism; Structure-Activity Relationship; Tryptophan | 2014 |
Indoleamine 2,3-dioxygenase inhibition alters the non-coding RNA transcriptome following renal ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Graft Rejection; Graft Survival; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Transplantation; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Untranslated; Transcriptome; Tryptophan | 2014 |
Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Recombinant Proteins; Substrate Specificity; Tryptophan | 2014 |
Clinical significance of tryptophan metabolism in the nontumoral hemisphere in patients with malignant glioma.
Topics: Adult; Aged; Brain; Brain Neoplasms; Female; Glioma; Humans; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Prognosis; Proportional Hazards Models; Serotonin; Tryptophan | 2014 |
Levo-1-methyl tryptophan aggravates the effects of mouse hepatitis virus (MHV-A59) infection.
Topics: Alanine Transaminase; Animals; Antibodies, Viral; Aspartate Aminotransferases; Autoantibodies; Cell Line; Coronavirus Infections; Female; Hepatitis, Viral, Animal; HMGB1 Protein; Hydrolases; Hypergammaglobulinemia; Immunoglobulins; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Liver; Mice, Inbred BALB C; Murine hepatitis virus; Tryptophan; Uric Acid | 2015 |
Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice, Knockout; Tryptophan; Tunica Media; Vascular Cell Adhesion Molecule-1 | 2015 |
Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets.
Topics: Dimerization; Electrons; Helium; Histidine; Hydrogen Bonding; Indoles; Mass Spectrometry; Models, Chemical; Protons; Temperature; Tryptophan | 2015 |
[The immunological characteristics of tonsil mesenchymal stem cells].
Topics: Cell Proliferation; Cells, Cultured; Child; Coculture Techniques; Flow Cytometry; Humans; Immunosuppression Therapy; Kynurenine; Leukocytes, Mononuclear; Lymphocyte Culture Test, Mixed; Mesenchymal Stem Cells; Palatine Tonsil; Tryptophan | 2015 |
Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Enzyme Inhibitors; Female; Gene Expression Regulation; Gene Regulatory Networks; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; NF-kappa B; Severity of Illness Index; Signal Transduction; Sodium Dodecyl Sulfate; Toll-Like Receptor 2; Toll-Like Receptor 6; Transcription, Genetic; Transcriptome; Tryptophan | 2015 |
Indoleamine 2,3-dioxygenase mediates inhibition of virus-specific CD8(+) T cell proliferation by human mesenchymal stromal cells.
Topics: CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytomegalovirus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mesenchymal Stem Cells; Tryptophan | 2016 |
Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.
Topics: Amino Acids; Anti-HIV Agents; Antiviral Agents; Dendrimers; Enterovirus A, Human; Enterovirus Infections; HIV Infections; HIV-1; HIV-2; Humans; Structure-Activity Relationship; Tryptophan; Virus Replication | 2017 |
Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor D-1-methyl-tryptophan.
Topics: Animals; Antibodies, Bispecific; Antibodies, Neoplasm; Antibody-Dependent Cell Cytotoxicity; Antigens, CD19; CD3 Complex; Cell Line; Cell Line, Tumor; HEK293 Cells; Heterografts; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; K562 Cells; Lymphoma, B-Cell; Mesenchymal Stem Cells; Mice; Single-Chain Antibodies; T-Lymphocytes; Tryptophan | 2017 |
Synthesis of 5-[
Topics: Animals; Fluorine Radioisotopes; HeLa Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Staining and Labeling; Tryptophan | 2017 |
1-Methyl-L-tryptophan promotes the apoptosis of hepatic stellate cells arrested by interferon-γ by increasing the expression of IFN-γRβ, IRF-1 and FAS.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line; Cell Survival; fas Receptor; Hepatic Stellate Cells; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon gamma Receptor; Interferon Regulatory Factor-1; Interferon-gamma; Liver Cirrhosis; Receptors, Interferon; Signal Transduction; Tryptophan | 2017 |
Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Topics: Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Goblet Cells; HT29 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Receptor, Notch1; Receptors, Aryl Hydrocarbon; Transcription Factor HES-1; Tryptophan; Wnt Signaling Pathway | 2018 |
Mathematical modelling of the synergistic combination of radiotherapy and indoleamine-2,3-dioxygenase (IDO) inhibitory immunotherapy against glioblastoma.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radiation; Glioblastoma; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Models, Theoretical; Rats; Rats, Inbred F344; Tryptophan | 2018 |
Automated GMP-production of α-[
Topics: Automation; Carbon Radioisotopes; Chemistry Techniques, Synthetic; Quality Control; Radioactive Tracers; Radiochemistry; Tryptophan | 2018 |
The enhanced antitumour response of pimozide combined with the IDO inhibitor L‑MT in melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Drug Synergism; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Pimozide; Skin Neoplasms; Tryptophan; Xenograft Model Antitumor Assays | 2018 |
IDO, COX and iNOS have an important role in the proliferation of Neospora caninum in neuron/glia co-cultures.
Topics: Animals; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Host-Parasite Interactions; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indomethacin; Interleukin-10; Neospora; Neuroglia; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Sulfonamides; Tryptophan; Tumor Necrosis Factor-alpha | 2019 |
1-Methyl tryptophan, an indoleamine 2,3-dioxygenase inhibitor, attenuates cardiac and hepatic dysfunction in rats with biliary cirrhosis.
Topics: Animals; Liver Cirrhosis, Biliary; Rats; Tryptophan | 2021 |
The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation.
Topics: Acute Kidney Injury; Animals; Azo Compounds; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; DNA Damage; Enzyme Inhibitors; Epithelial Cells; Humans; Hypoxia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kidney Tubules, Proximal; Mice; Oxygen; Protein Serine-Threonine Kinases; Pyrazoles; Receptors, Aryl Hydrocarbon; Reperfusion Injury; rho GTP-Binding Proteins; Tryptophan | 2021 |