tryptophan and substance p

tryptophan has been researched along with substance p in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (9.26)	18.7374
1990's	12 (22.22)	18.2507
2000's	17 (31.48)	29.6817
2010's	19 (35.19)	24.3611
2020's	1 (1.85)	2.80

Authors

Authors	Studies
Werle, E	1
Felder, M	1
Koegel, A; Mangel, AW	1
Dun, NJ; Kiraly, M; Ma, RC	1
D'Orléans-Juste, P; Dion, S; Drapeau, G; Escher, E; Mizrahi, J; Regoli, D	1
Ber, E; Cascieri, MA; Macleod, AM; Merchant, KJ; Sadowski, S; Shiao, LL; Strader, CD; Swain, CJ; Underwood, D; Yu, H	1
Chan, MY; Tang, F	1
Ber, E; Brookfield, F; Casiceri, MA; Kelleher, F; MacLeod, AM; Merchant, KJ; Owens, AP; Sadowski, S; Stevenson, G; Swain, CJ	1
Barrow, CJ; Brownell, JE; Gillum, AM; Hong, A; Houck, DR; Sedlock, DM	1
Cummings, J; Langdon, SP; MacLellan, A; Rozengurt, E; Smyth, JF	1
Cascieri, MA; Fong, TM; Hardwicke, S; Lewis, RT; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Sadowski, S; Shepheard, S	1
Isobe, T; Okuyama, T; Shinoda, T; Yamaki, S	1
Field, MJ; Hughes, J; Kuo, BS; Naylor, RJ; Singh, L; Suman-Chauhan, N; Tuladhar, BR; Wright, DS	1
Boudon, A; Fauchère, JL; Jacoby, E; Kucharczyk, N; Michel, A	1
Field, MJ; Gonzalez, MI; Holloman, EF; Hughes, J; Oles, RJ; Singh, L	1
Nowicki, PT	1
Ackenheil, M; Bondy, B; Müller-Bardorff, H; Pongratz, DE; Schwarz, MJ; Späth, M	1
Ganesan, A; Wang, H	1
Hwang, KH; Kuo, HP; Lin, HC; Lu, LC; Wang, CH	1
Cahill, CM; Coderre, TJ	1
Khoo, HE; Low, KS; Sung, JM	1
Bredesen, DE; Castro-Obregón, S; Chen, SF; Del Rio, G; Frankowski, H; Nicholls, DG; Rao, RV; Stoka, V; Swanson, RA; Vesce, S	1
El-Mahmoudy, A; Khalifa, M; Matsuyama, H; Shimizu, Y; Takewaki, T	1
Cernak, I; Cruz, MI; Donkin, JJ; Nimmo, AJ; Vink, R	1
Liu, H; Wang, L; Zhang, G; Zhang, J	1
Howe, HE; Sladek, CD; Somponpun, SJ	1
Gardell, LR; Hruby, VJ; Hunt, SP; King, T; Lai, J; Malan, PT; Ossipov, MH; Porreca, F; Vanderah, TW; Vardanyan, A; Wang, R	1
Inoue, T; Kamei, C; Rahman, MA	1
Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M	1
Arreola, JL; Chávez, J; Flores-Soto, E; Montaño, LM; Segura, P; Vargas, MH	1
Coveñas, R; González-Moles, MA; Montero, I; Muñoz, M; Robles, MJ; Rosso, M	1
Aguilar, FJ; Esteban, F; González-Moles, MA; Muñoz, M; Redondo, M; Rosso, M	1
Choi, JY; Hanrahan, JW; Ianowski, JP; Wine, JJ	1
Blumbergs, PC; Cernak, I; Donkin, JJ; Nimmo, AJ; Vink, R	1
Bullens, DM; Cadot, P; Callebaut, I; Ceuppens, JL; Hellings, PW; Hens, G; Meyts, I; Nemery, B; Raap, U; Vanaudenaerde, BM; Vanoirbeek, J; Verbinnen, B	1
Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K	1
Coveñas, R; González-Ortega, A; Muñoz, M	1
Barry, CM; den Heuvel, Cv; Helps, SC; Vink, R	1
Helps, SC; Thornton, E; Turner, RJ; Vink, R	1
Janicki, JS; Law, BA; Levick, SP; Li, J; Meléndez, GC; Supowit, SC	1
Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N	1
Thornton, E; Vink, R	1
Carthew, HL; Vink, R; Ziebell, JM	1
Corrigan, F; Ghabriel, M; Leonard, A; Van Den Heuvel, C; Vink, R	1
Hayashi, H; Oh-ishi, T; Onaga, T; Shimoda, T	1
Carranza, A; Coveñas, R; González-Ortega, A; Muñoz, M; Robles-Frias, MJ; Rosso, M; Salinas-Martín, MV	1
Bienenstock, J; El Aidy, S; Kleerebezem, M; Kunze, W	1
Chen, T; Ji, W; Li, H; Li, YQ; Pei, LY; Wang, W; Wu, SX; Zhang, MM; Zhang, T	1
Leonard, AV; Thornton, E; Vink, R	1
Almendro, V; Carranza, A; Coveñas, R; Garcia-Recio, S; González-Ortega, A; Muñoz, M; Salinas-Martín, MV	1
Dai, GH; Deng, WT; Guo, XD; Huang, KB; Luo, GQ; Pan, SY; Peng, KR; Qian, NS; Wu, XN; Xiang, W; Yang, HJ; Zhang, T	1
Friedlander, RM; Jiang, J; Li, W; Mao, LL; Sirianni, AC; Sugarbaker, P; Wang, X; Zeng, J; Zhang, X; Zhou, S	1
Aicher, B; Banères, JL; Blayo, AL; Damian, M; Denoyelle, S; Fehrentz, JA; Gagne, D; Günther, E; M'Kadmi, C; Maingot, M; Marie, J; Martinez, J; Mary, S; Müller, G; Sanchez, P; Schmidt, P; Teifel, M	1
Lipiński, PFJ; Matalińska, J	1

Reviews

2 review(s) available for tryptophan and substance p

Article	Year
[Tissue hormones. A review]. Arztliche Forschung, 1968, Jan-10, Volume: 22, Issue:1 Topics: Acetylcholine; Amines; Aminobutyrates; Angiotensin II; Animals; Bradykinin; Cholecystokinin; Dopamine; Epinephrine; Gastrins; Gastrointestinal Hormones; Histamine; Hormones; Kallidin; Kallikreins; Norepinephrine; Peptides; Prostaglandins; Renin; Secretin; Serotonin; Substance P; Tryptophan; Vasopressins	1968
[The fibrositis syndrome (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1980, Feb-05, Volume: 69, Issue:5 Topics: Adult; Behavior Therapy; Chlorpromazine; Edema; Endorphins; Female; Fibromyalgia; Humans; Male; Middle Aged; Neurotic Disorders; Obesity; Pain; Pain Management; Sleep Wake Disorders; Substance P; Syndrome; Tryptophan	1980

Other Studies

52 other study(ies) available for tryptophan and substance p

Article	Year
Effects of peptides on gastric emptying. The American journal of physiology, 1984, Volume: 246, Issue:4 Pt 1 Topics: Animals; Gastric Emptying; Male; Neurotensin; Phenylalanine; Rats; Sincalide; Substance P; Tryptophan; Vasoactive Intestinal Peptide	1984
Evidence for a serotonin-mediated slow excitatory potential in the guinea-pig coeliac ganglia. The Journal of physiology, 1984, Volume: 351 Topics: Action Potentials; Animals; Calcium; Cell Membrane; Cyproheptadine; Fluoxetine; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Magnesium; Membrane Potentials; Neurons; Parasympatholytics; Serotonin; Substance P; Tryptophan	1984
A substance P antagonist not containing D-tryptophan. European journal of pharmacology, 1984, Oct-15, Volume: 105, Issue:3-4 Topics: Animals; Cricetinae; Dogs; Guinea Pigs; Ileum; In Vitro Techniques; Peptide Fragments; Rats; Substance P; Tryptophan; Urinary Bladder	1984
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. The Journal of biological chemistry, 1994, Mar-04, Volume: 269, Issue:9 Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Histidine; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Protein Conformation; Quinuclidines; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Transfection; Tryptophan	1994
Brain cholecystokinin octopeptide (CCK-8) concentrations: effect of tryptophan and other serotonergic agents. Neuropeptides, 1994, Volume: 26, Issue:1 Topics: Animals; Brain Chemistry; Corpus Striatum; Cyproheptadine; Drug Interactions; Dynorphins; Hippocampus; Hydroxyindoleacetic Acid; Hypothalamus; Imipramine; Male; Proglumide; Rats; Serotonin; Serotonin Receptor Agonists; Sincalide; Substance P; Tryptophan	1994
Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. Journal of medicinal chemistry, 1994, Apr-29, Volume: 37, Issue:9 Topics: Acylation; Amino Acid Sequence; Animals; CHO Cells; Computer Simulation; Cricetinae; Dermatitis, Contact; Guinea Pigs; Humans; Male; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Recombinant Proteins; Structure-Activity Relationship; Substance P; Tryptophan	1994
WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. I. Fermentation and isolation. The Journal of antibiotics, 1994, Volume: 47, Issue:4 Topics: Aspergillus; Astrocytoma; Binding Sites; Chromatography, High Pressure Liquid; Culture Media; Fermentation; Humans; Indoles; Piperazines; Spectrometry, Mass, Fast Atom Bombardment; Substance P; Tryptophan; Tumor Cells, Cultured	1994
Determination of two neuropeptide growth factor antagonists, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P and [Arg6,D-Trp7,9,N-MePhe8]- substance P(6-11), by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical applications, 1994, Mar-04, Volume: 653, Issue:2 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Electrochemistry; Growth Inhibitors; Humans; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Transplantation; Peptide Fragments; Substance P; Tryptophan	1994
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan. Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6 Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan	1995
Reversed-phase liquid chromatography on a microspherical carbon column at high temperature. Journal of chromatography. A, 1996, Mar-29, Volume: 728, Issue:1-2 Topics: Amino Acid Sequence; Amino Acids; Angiotensin I; Carbon; Chromatography, High Pressure Liquid; Drug Stability; Hot Temperature; Hydrogen-Ion Concentration; Microspheres; Molecular Sequence Data; Substance P; Tryptophan	1996
The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret. European journal of pharmacology, 1997, Feb-26, Volume: 321, Issue:2 Topics: Animals; Antiemetics; Antineoplastic Agents; Behavior, Animal; Brain; CHO Cells; Cisplatin; Cricetinae; Dogs; Female; Ferrets; Gerbillinae; Guinea Pigs; Humans; Male; Mice; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Sensitivity and Specificity; Sheep; Substance P; Swine; Time Factors; Tryptophan; Vomiting	1997
A structural rationale for the design of water soluble peptide-derived neurokinin-1 antagonists. Journal of receptor and signal transduction research, 1997, Volume: 17, Issue:6 Topics: Animals; Biphenyl Compounds; Dipeptides; Drug Design; Humans; In Vitro Techniques; Indoles; Models, Chemical; Models, Molecular; Molecular Mimicry; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Solubility; Substance P; Tetrazoles; Tryptophan; Water	1997
Evaluation of PD 154075, a tachykinin NK1 receptor antagonist, in a rat model of postoperative pain. European journal of pharmacology, 1998, Mar-05, Volume: 344, Issue:2-3 Topics: Anesthetics; Animals; Excitatory Amino Acid Antagonists; Isoflurane; Male; Pain Threshold; Pain, Postoperative; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tryptophan	1998
Postnatal changes in gut hemodynamics: a possible role for substance P. The American journal of physiology, 1998, Volume: 274, Issue:6 Topics: Animals; Animals, Newborn; Endothelium, Vascular; Hemodynamics; Intestines; Kinetics; Mesenteric Arteries; Muscle Denervation; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; omega-N-Methylarginine; Oxygen Consumption; Substance P; Swine; Tryptophan; Vascular Resistance	1998
Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients. Neuroscience letters, 1999, Jan-15, Volume: 259, Issue:3 Topics: Adult; Biomarkers; Female; Fibromyalgia; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Pain; Sleep; Substance P; Tryptophan	1999
Total synthesis of the fumiquinazoline alkaloids: solution-phase studies. The Journal of organic chemistry, 2000, Feb-25, Volume: 65, Issue:4 Topics: Alkaloids; Antineoplastic Agents; Fungi; ortho-Aminobenzoates; Quinazolines; Substance P; Tryptophan	2000
Lipopolysaccharide enhances substance P-mediated neutrophil adherence to epithelial cells and cytokine release. American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:5 Topics: CD18 Antigens; Cell Adhesion; Epithelial Cells; Humans; In Vitro Techniques; Interleukin-1; Lipopolysaccharides; Lung; Macrophage-1 Antigen; Neurokinin-1 Receptor Antagonists; Neutrophils; RNA, Messenger; Serine Proteinase Inhibitors; Substance P; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	2000
Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist. Pain, 2002, Volume: 95, Issue:3 Topics: Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Rats; Rats, Long-Evans; Sciatica; Substance P; Tryptophan	2002
Characterization of the mechanism underlying stonustoxin-mediated relaxant response in the rat aorta in vitro. Biochemical pharmacology, 2002, Mar-15, Volume: 63, Issue:6 Topics: Animals; Aorta; Drug Interactions; Enzyme Inhibitors; Fish Venoms; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Substance P; Thiazines; Tryptophan; Vasodilation	2002
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell death and differentiation, 2002, Volume: 9, Issue:8 Topics: Animals; Annexin A5; Apoptosis; Caspase Inhibitors; Caspases; Cell Size; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fetus; Humans; Immunohistochemistry; Kidney; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Prosencephalon; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tryptophan	2002
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors. Life sciences, 2003, Aug-29, Volume: 73, Issue:15 Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan	2003
A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats. Journal of the American College of Nutrition, 2004, Volume: 23, Issue:5 Topics: Animals; Brain Injuries; Homeostasis; Magnesium; Magnesium Deficiency; Magnetic Resonance Spectroscopy; Male; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan	2004
Substance P promotes sleep in the ventrolateral preoptic area of rats. Brain research, 2004, Dec-03, Volume: 1028, Issue:2 Topics: 3-Mercaptopropionic Acid; Animals; Electroencephalography; Electromyography; Estrenes; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Phosphodiesterase Inhibitors; Polysomnography; Preoptic Area; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Sleep; Substance P; Tryptophan; Wakefulness	2004
Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45 Topics: Acetates; Animals; Catecholamines; Cell Compartmentation; Cell Nucleus; Cytoplasm; Endosomes; Hydralazine; Hypotension; Hypothalamo-Hypophyseal System; Hypothalamus, Anterior; Male; Microinjections; Microscopy, Confocal; Neurons; Oxytocin; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Transcription, Genetic; Tryptophan; Vasopressins	2004
Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain, 2005, Volume: 116, Issue:3 Topics: Animals; Cell Count; Drug Interactions; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Knockout; Morphine; Narcotics; Neurokinin-1 Receptor Antagonists; Pain Measurement; Protein Transport; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission; Time Factors; Touch; Tryptophan	2005
Role of substance P in allergic nasal symptoms in rats. European journal of pharmacology, 2006, Feb-17, Volume: 532, Issue:1-2 Topics: Animals; Antigens; Cyproheptadine; Dibenzazepines; Dibenzoxepins; Dose-Response Relationship, Drug; Electroencephalography; Histamine H1 Antagonists; Hypersensitivity; Imidazoles; Male; Neurokinin-1 Receptor Antagonists; Olopatadine Hydrochloride; Rats; Rats, Wistar; Sneezing; Substance P; Tryptophan	2006
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergology international : official journal of the Japanese Society of Allergology, 2006, Volume: 55, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan	2006
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release. American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4 Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan	2007
Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138. Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:6 Topics: Apoptosis; Blotting, Western; Cell Count; Cell Proliferation; Child, Preschool; Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Retinal Neoplasms; Retinoblastoma; Stereoisomerism; Substance P; Tryptophan; Tumor Cells, Cultured	2007
NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2. Investigational new drugs, 2008, Volume: 26, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Laryngeal Neoplasms; Mitosis; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan	2008
Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands. Pflugers Archiv : European journal of physiology, 2008, Volume: 457, Issue:2 Topics: Animals; Benzoates; Capsaicin; Clotrimazole; Cystic Fibrosis Transmembrane Conductance Regulator; Exocrine Glands; Irritants; Mice; Mice, Inbred CFTR; Mucus; Neurokinin-1 Receptor Antagonists; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Receptors, Neurokinin-1; Respiratory Mucosa; Substance P; Thiazolidines; Time Factors; Trachea; Tryptophan	2008
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:8 Topics: Animals; Brain Edema; Brain Injuries; Capillary Permeability; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Magnetic Resonance Imaging; Male; Microscopy, Confocal; Microscopy, Immunoelectron; Motor Activity; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan	2009
Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness. American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:4 Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Immunization; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nasal Provocation Tests; Neurokinin-1 Receptor Antagonists; Ovalbumin; Receptors, Neurokinin-1; Substance P; Tryptophan; Up-Regulation	2011
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. Neuroscience, 2010, Dec-29, Volume: 171, Issue:4 Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation	2010
The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines. Investigational new drugs, 2012, Volume: 30, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Substance P; Tryptophan	2012
Characterizing the role of the neuropeptide substance P in experimental subarachnoid hemorrhage. Brain research, 2011, May-10, Volume: 1389 Topics: Animals; Brain Edema; Intracranial Hypertension; Male; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Substance P; Tryptophan	2011
A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke. Brain research, 2011, Jun-01, Volume: 1393 Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Infarction, Middle Cerebral Artery; Male; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Recovery of Function; Substance P; Time Factors; Tryptophan	2011
Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells. Cardiovascular research, 2011, Dec-01, Volume: 92, Issue:3 Topics: Animals; Apoptosis; Cell Degranulation; Collagen; Disease Models, Animal; Heart Failure; In Situ Nick-End Labeling; Male; Mast Cells; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha; Ultrasonography; Ventricular Remodeling	2011
Pharmacological characteristics of endokinin C/D-derived peptides in nociceptive and inflammatory processing in rats. Peptides, 2011, Volume: 32, Issue:12 Topics: Amino Acid Sequence; Amino Acids; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Formaldehyde; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Nociceptive Pain; Pain Measurement; Peptide Fragments; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins; Time Factors; Tryptophan	2011
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease. PloS one, 2012, Volume: 7, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cells; Dopaminergic Neurons; Inflammation; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Substance P; Substantia Nigra; Tryptophan	2012
Substance P-induced changes in cell genesis following diffuse traumatic brain injury. Neuroscience, 2012, Jul-12, Volume: 214 Topics: Animals; Brain Injuries; Cell Differentiation; Male; Microglia; Neurogenesis; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tryptophan	2012
A substance P antagonist improves outcome in female Sprague Dawley rats following diffuse traumatic brain injury. CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:6 Topics: Animals; Brain Injuries; Disease Models, Animal; Female; Motor Activity; Rats; Rats, Sprague-Dawley; Substance P; Tryptophan	2012
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep. Neuropeptides, 2013, Volume: 47, Issue:1 Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan	2013
The substance P/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists. Peptides, 2012, Volume: 38, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tryptophan; Tumor Cells, Cultured	2012
The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. Beneficial microbes, 2012, Dec-01, Volume: 3, Issue:4 Topics: Animals; Bacteria; Brain; Colon; Enzyme Activation; Feces; Gene Expression Profiling; Gene Expression Regulation; Germ-Free Life; Homeostasis; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Intestine, Small; Kynuramine; Male; Metagenome; Mice; Mice, Inbred C57BL; Neurons; Stress, Physiological; Substance P; Synaptic Transmission; Time Factors; Tryptophan	2012
Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord. PloS one, 2013, Volume: 8, Issue:3 Topics: Acute Disease; Animals; Colitis; Colon; Formaldehyde; Gene Expression; Lumbosacral Region; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Nociceptive Pain; Protein Transport; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tryptophan	2013
NK1 receptor blockade is ineffective in improving outcome following a balloon compression model of spinal cord injury. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Inflammation; Neurokinin-1 Receptor Antagonists; Protease Inhibitors; Rabbits; Receptors, Neurokinin-1; Spinal Cord Compression; Substance P; Tryptophan	2014
The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer. International journal of oncology, 2014, Volume: 45, Issue:4 Topics: Antineoplastic Agents; Aprepitant; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MCF-7 Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan	2014
Antinociceptive effects of endomorphin-2: suppression of substance P release in the inflammatory pain model rat. Neurochemistry international, 2015, Volume: 82 Topics: Animals; Arthritis, Experimental; Chronic Pain; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociception; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, Presynaptic; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Mechanical; Substance P; Tryptophan	2015
N-acetyl-l-tryptophan, but not N-acetyl-d-tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. Journal of neurochemistry, 2015, Volume: 134, Issue:5 Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Caspases; Cell Line; Cytochromes c; Drug Evaluation, Preclinical; Hybrid Cells; Interleukin-1beta; Mice; Mitochondria; Motor Neurons; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Proteasome Endopeptidase Complex; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Tryptophan	2015
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center. Bioorganic & medicinal chemistry letters, 2016, 05-15, Volume: 26, Issue:10 Topics: Fluorescence Resonance Energy Transfer; Indoles; Inhibitory Concentration 50; Ligands; Receptors, Ghrelin; Structure-Activity Relationship; Substance P; Triazoles; Tryptophan	2016
Correcting a widespread error: Neuroprotectant N-acetyl-L-tryptophan does not bind to the neurokinin-1 receptor. Molecular and cellular neurosciences, 2022, Volume: 120 Topics: Acetylation; Animals; Neuroprotection; Neuroprotective Agents; Rats; Receptors, Neurokinin-1; Substance P; Tryptophan	2022