tryptophan has been researched along with sapropterin in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (30.56) | 18.7374 |
| 1990's | 10 (27.78) | 18.2507 |
| 2000's | 11 (30.56) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 2 |
| Diksic, M; Sourkes, TL | 1 |
| Koshimura, K; Lee, K; Miwa, S; Ohue, T; Watanabe, Y | 1 |
| Hayashi, T; Nakane, A; Naruse, H; Takesada, M; Yamazaki, K | 1 |
| Bushnell, IW; McIntosh, MJ; Moore, MR | 1 |
| Nichol, CA; Ozaki, Y; Reinhard, JF | 1 |
| Lee, EH; Mandell, AJ | 1 |
| Baumann, P | 1 |
| Hayaishi, O; Miwa, S; Watanabe, Y | 1 |
| Knapp, S; Mandell, AJ; Russo, PV; Stewart, KD; Vitto, A | 1 |
| Knapp, S; Mandell, AJ | 1 |
| Kaufman, S; Parniak, MA; Phillips, RS | 1 |
| Kuhn, DM; Lovenberg, W | 1 |
| Haavik, J; Knappskog, PM | 1 |
| Apelqvist, G; Bengtsson, F; Bergqvist, PB; Bugge, M; Wachter, H; Werner, ER | 1 |
| Hartvig, P; Långström, B; Lindner, KJ; Tsukada, H | 1 |
| Heyes, MP; Kaufman, S; Milstien, S; Saito, K; Sakai, N | 1 |
| Cotton, RG; Dianzani, I; Howells, DW; Ponzone, A; Saleeba, JA; Smooker, PM | 1 |
| Arthur, RE; D'Sa, CM; Kuhn, DM; States, JC | 1 |
| Abou-Saleh, MT; Anderson, DN; Ghubash, R; Karim, L; Krymski, M | 1 |
| Crawley, J; Dobbie, M; Marsh, K; Surtees, R; Waruiru, C | 1 |
| Daff, S; Sagami, I; Sato, Y; Shimizu, T | 1 |
| Ghosh, S; Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Aoyagi, M; Arvai, AS; Getzoff, ED; Ghosh, S; Stuehr, DJ; Tainer, JA | 1 |
| Watanabe, Y | 1 |
| Coleman, CM; Neckameyer, WS | 1 |
| Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Aghajanian, GK; Lambe, EK; Liu, RJ | 1 |
| Hasegawa, H; Hirose, S; Lin, QS; Nakamura, K; Nishimura, H; Ohashi, A; Ohtsuji, M; Sawabe, K; Sugawara, Y; Tsurui, H; Xiu, Y | 1 |
| Artuch, R; Campistol, J; Gómez, L; Lambruschini, N; Ormazabal, A; Pérez-Dueñas, B; Vilaseca, MA | 1 |
| Lee, KH; Lee, SY; Park, SO; Park, YS; Seo, KH; Supangat, S | 1 |
| Bailey, J; Batchelor, H; Benson, MA; Bhattacharya, S; Channon, KM; Chuaiphichai, S; Crabtree, MJ; Stuehr, DJ; Zhu, H | 1 |
| Anikster, Y; Ben-Zeev, B; Benoist, JF; Berutti, R; Blau, N; Bruggmann, R; Cremer, K; Dorboz, I; Engels, H; Gahl, WA; Gemperle-Britschgi, C; Guarani, V; Haack, TB; Harper, JW; Heimer, G; Hoffmann, GF; Huttlin, EL; Imbard, A; Keller, I; Landau, Y; Malicdan, MCV; Marek-Yagel, D; Martinez, A; Mayatepek, E; Meili, D; Meissner, T; Meitinger, T; Mullikin, JC; Opladen, T; Paulo, JA; Pode-Shakked, B; Prokisch, H; Schiff, M; Schwartz, G; Shen, N; Strom, TM; Thöny, B; Trefz, FK; Vilboux, T; Ziv-Strasser, L | 1 |
| Christensen, HEM; Harris, P; Peters, GH; Stensgaard, E; Tidemand, KD | 1 |
| Feist, AM; Herrgard, M; Kim, SH; Luo, H; Palsson, BØ; Wulff, T; Yang, L | 1 |
4 review(s) available for tryptophan and sapropterin
| Article | Year |
|---|---|
The neurotoxicology of lead.
Topics: Amino Acids; Aminolevulinic Acid; Animals; Biopterins; Brain; Child; Energy Metabolism; gamma-Aminobutyric Acid; Humans; Lead; Lead Poisoning; Nervous System; Norepinephrine; Prospective Studies; Tryptophan; Tyrosine 3-Monooxygenase | 1986 |
Substrate regulation of serotonin synthesis.
Topics: Animals; Biopterins; Nervous System; Oxygen Consumption; Rats; Serotonin; Tryptophan | 1982 |
Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine.
Topics: Animals; Arginine; Biopterins; Cell Line; Cells, Cultured; Cytokines; Humans; Hydroxylation; Interferon-gamma; Macrophages; Mice; Mice, Inbred C57BL; Models, Biological; Monocytes; Nitric Oxide; Pterins; Skin; Tryptophan; Tumor Necrosis Factor-alpha | 1993 |
[Neural and molecular mechanisms of fatigue and recovery from fatigue].
Topics: Acetylcarnitine; Ascorbic Acid; Biopterins; Brain; Cytokines; Fatigue; Glutamic Acid; Humans; Nerve Net; Serotonin; Tomography, Emission-Computed; Tryptophan | 2003 |
1 trial(s) available for tryptophan and sapropterin
| Article | Year |
|---|---|
[Metabolic changes in aromatic amino acids and monoamines in infantile autism and development of new treatment related to the finding].
Topics: 5-Hydroxytryptophan; Amino Acids; Autistic Disorder; Biogenic Monoamines; Biopterins; Carbon Isotopes; Child; Child, Preschool; Clinical Trials as Topic; Deuterium; Double-Blind Method; Humans; Levodopa; Phenylalanine; Tryptophan | 1989 |
31 other study(ies) available for tryptophan and sapropterin
| Article | Year |
|---|---|
Relationships between pteridine synthesis and tryptophan degradation.
Topics: Biopterins; Cells, Cultured; Enzyme Induction; Humans; Hydrolases; Interferon-gamma; Macrophages; NAD; Neopterin; Pteridines; Tryptophan; Tryptophan Oxygenase | 1991 |
Autoradiographic measurement of the rate of serotonin synthesis in the rat brain.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Autoradiography; Biopterins; Brain; Brain Chemistry; Kinetics; Models, Biological; Oxygen; Rats; Serotonin; Tryptophan; Tryptophan Hydroxylase | 1991 |
A novel action of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin, a cofactor for hydroxylases of phenylalanine, tyrosine and tryptophan: enhancement of acetylcholine release in vivo in the rat hippocampus.
Topics: Acetylcholine; Animals; Biopterins; Choline; Chromatography, High Pressure Liquid; Dialysis; Hippocampus; Injections, Intraventricular; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Reserpine; Tetrodotoxin; Tryptophan; Tyrosine | 1991 |
Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.
Topics: Biopterins; Coenzymes; Enzyme Activation; Fibroblasts; GTP Cyclohydrolase; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Macrophages; Neopterin; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 1989 |
Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase.
Topics: Animals; Biopterins; Epididymis; Flavin Mononucleotide; Hydrogen-Ion Concentration; Kinetics; Male; Mice; Oxygenases; Tryptophan; Tryptophan Oxygenase | 1986 |
Relationships between drug-induced changes in tetrahydrobiopterin and biogenic amine concentrations in rat brain.
Topics: Animals; Biogenic Amines; Biopterins; Brain Chemistry; Circadian Rhythm; Cocaine; Corticotropin-Releasing Hormone; Dextroamphetamine; Male; Methylphenidate; Pteridines; Rats; Rats, Inbred Strains; Tryptophan; Valine | 1985 |
Transport systems and enzymes involved in the metamorphosis of tryptophan into serotonin.
Topics: Animals; Biopterins; Biotransformation; Brain; Humans; Intestinal Absorption; Kinetics; Oxygenases; Serotonin; Tryptamines; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase | 1985 |
6R-L-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain.
Topics: Animals; Biopterins; Brain; Dopamine; Hydroxylation; Isomerism; Probenecid; Pteridines; Rats; Serotonin; Time Factors; Tryptophan; Tyrosine | 1985 |
Strain differences in kinetic and thermal stability of two mouse brain tryptophan hydroxylase activities.
Topics: Animals; Biopterins; Brain; Hydroxyindoleacetic Acid; Kinetics; Male; Mice; Mice, Inbred Strains; Serotonin; Species Specificity; Temperature; Tryptophan; Tryptophan Hydroxylase | 1981 |
Scattering kinetics in a complex tryptophan hydroxylase preparation from rat brainstem raphe nuclei: statistical evidence that the lithium-induced sigmoid velocity function reflects two states of available catalytic potential.
Topics: Animals; Biopterins; Brain Stem; Catalysis; Kinetics; Lithium; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Statistics as Topic; Tryptophan; Tryptophan Hydroxylase | 1983 |
The interaction of aromatic amino acids with rat liver phenylalanine hydroxylase.
Topics: Amino Acids; Animals; Biopterins; Kinetics; Liver; Male; Phenylalanine; Phenylalanine Hydroxylase; Rats; Rats, Inbred Strains; Stereoisomerism; Tryptophan | 1984 |
Tryptophan fluorescence of human phenylalanine hydroxylase produced in Escherichia coli.
Topics: Acrylamide; Acrylamides; Base Sequence; Biopterins; DNA, Complementary; Escherichia coli; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Phenylalanine Hydroxylase; Polymerase Chain Reaction; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Tryptophan | 1995 |
Brain biopterin metabolism in chronic experimental hepatic encephalopathy.
Topics: Animals; Biopterins; Body Weight; Brain Chemistry; Chronic Disease; Exploratory Behavior; GTP Cyclohydrolase; Hepatic Encephalopathy; Male; Motor Activity; Organ Size; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan | 1995 |
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion.
Topics: Amines; Animals; Biopterins; Corpus Striatum; Dopamine; Extracellular Space; Infusions, Parenteral; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1994 |
Two new mutations in the dihydropteridine reductase gene in patients with tetrahydrobiopterin deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Aspartic Acid; Base Sequence; Biopterins; Conserved Sequence; Dihydropteridine Reductase; DNA Mutational Analysis; Glycine; Humans; Infant; Infant, Newborn; Male; Molecular Sequence Data; Nucleic Acid Heteroduplexes; Point Mutation; Tryptophan | 1993 |
Tryptophan hydroxylase: cloning and expression of the rat brain enzyme in mammalian cells.
Topics: Animals; Antioxidants; Base Sequence; Biopterins; Cell Line; Chromatography, Gel; Cloning, Molecular; Cross Reactions; Deferoxamine; Dopamine; Enzyme Activation; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Iron; Male; Mammals; Mesencephalon; Molecular Sequence Data; Phenylalanine Hydroxylase; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serotonin; Siderophores; Transfection; Tryptophan; Tryptophan Hydroxylase | 1996 |
The role of pterins and related factors in the biology of early postpartum depression.
Topics: Adult; Analysis of Variance; Biopterins; Depression, Postpartum; Female; Folic Acid; Humans; Hydrocortisone; Postpartum Period; Pterins; Tryptophan | 1999 |
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?
Topics: Antimalarials; Biopterins; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Endothelium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Infant; Kenya; Malaria, Cerebral; Microglia; Neopterin; Nitrates; Nitrites; Quinolinic Acid; Tryptophan | 2000 |
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan | 2000 |
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Conserved Sequence; Electron Spin Resonance Spectroscopy; Electrons; Heme; Kinetics; Light; Mice; Models, Chemical; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Protein Binding; Spectrophotometry; Time Factors; Tryptophan | 2001 |
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Topics: Animals; Binding Sites; Biopterins; Catalysis; Conserved Sequence; Crystallography, X-Ray; Dimerization; Electron Transport; Escherichia coli; Heme; Hydrogen Bonding; Mice; Models, Chemical; Models, Molecular; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Binding; Recombinant Proteins; Tryptophan | 2001 |
Substrate regulation of serotonin and dopamine synthesis in Drosophila.
Topics: Animals; Biopterins; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Electrophoresis, Gel, Two-Dimensional; Immunoprecipitation; Iron; Phenylalanine; Phenylalanine Hydroxylase; Phosphorylation; Recombinant Fusion Proteins; Serotonin; Substrate Specificity; Time Factors; Tryptophan; Tryptophan Hydroxylase; Tyrosine | 2004 |
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan | 2005 |
Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Autoreceptors; Biopterins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylephrine; Piperazines; Pyridines; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists; Time Factors; Tryptophan; Tryptophan Hydroxylase | 2005 |
Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.
Topics: Animals; Antidepressive Agents; Biopterins; Brain; Chlorocebus aethiops; COS Cells; Depression; Enzyme Induction; Freezing Reaction, Cataleptic; Gene Expression Regulation, Developmental; Humans; Imipramine; Mice; Mice, Inbred Strains; Paroxetine; Raphe Nuclei; Recombinant Fusion Proteins; RNA, Messenger; Serotonin; Tryptophan; Tryptophan Hydroxylase | 2006 |
Platelet serotonin concentrations in PKU patients under dietary control and tetrahydrobiopterin treatment.
Topics: Adolescent; Adult; Biopterins; Blood Platelets; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diet; Female; Humans; Infant; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Serotonin; Tryptophan; Tryptophan Hydroxylase | 2005 |
Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Biopterins; Chlorobium; Computer Simulation; Enzyme Activation; Enzyme Stability; Models, Chemical; Models, Molecular; Molecular Sequence Data; Phenylalanine; Structure-Activity Relationship; Tryptophan | 2008 |
A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Binding Sites; Biocatalysis; Biopterins; Blotting, Western; Catalytic Domain; Humans; Mice; Models, Molecular; Mutation; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Multimerization; Superoxides; Tryptophan | 2013 |
Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability.
Topics: Alleles; Amino Acid Sequence; Biopterins; Case-Control Studies; Dopamine; Dystonia; Exons; Female; Fibroblasts; Gene Deletion; Genome-Wide Association Study; HSP70 Heat-Shock Proteins; Humans; Intellectual Disability; Male; Pedigree; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Repressor Proteins; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 2017 |
Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase.
Topics: Amino Acid Sequence; Biopterins; Catalytic Domain; Humans; Isoenzymes; Kinetics; Models, Molecular; Sequence Alignment; Substrate Specificity; Tryptophan; Tryptophan Hydroxylase | 2017 |
Directed Metabolic Pathway Evolution Enables Functional Pterin-Dependent Aromatic-Amino-Acid Hydroxylation in
Topics: 5-Hydroxytryptophan; Amino Acids, Aromatic; Biopterins; Dihydroxyphenylalanine; Directed Molecular Evolution; Escherichia coli; GTP Cyclohydrolase; Hydroxylation; Metabolic Networks and Pathways; Mutation; Phenylalanine Hydroxylase; Pterins; Tryptophan | 2020 |