Compounds > tryptophan

tryptophan and rg108

tryptophan has been researched along with rg108 in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (3.39)29.6817
2010's47 (79.66)24.3611
2020's10 (16.95)2.80

Authors

AuthorsStudies
Arimondo, PB; Asgatay, S; Ceccaldi, A; Champion, C; Drujon, T; Erdmann, A; Guianvarc'h, D; Jeltsch, A; Karoyan, P; Lequin, O; Marloie, G; Rajavelu, A; Schambel, P; Senamaud-Beaufort, C1
Brueckner, B; Garcia Boy, R; Kliem, HC; Lyko, F; Musch, T; Siedlecki, P; Suhai, S; Wiessler, M; Zielenkiewicz, P1
Brueckner, B; Lyko, F; Musch, T; Stopper, H; Stresemann, C1
Hamada, S; Miyata, N; Nakagawa, H; Suzuki, T; Tanaka, R1
Ashraf, M; Haider, HKh; Pasha, Z1
Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M1
Borutinskaite, VV; Navakauskiene, R; Savickiene, J; Treigyte, G1
Borutinskaite, VV; Jazdauskaite, A; Navakauskiene, R; Savickiene, J; Treigyte, G1
Appadurai, DA; Manning, J; May, JM; Mitchell, B; Nganga, V; Pierce, LJ; Shakya, A; Spangrude, GJ; Swanson, PC; Tantin, D; Wang, H1
Buzanska, L; Pastwinska, A; Pienkowska-Grela, B; Podobinska, M; Sypecka, J; Szablowska-Gadomska, I; Zayat, V1
Chiang, HC; Chiang, WF; Huang, HH; Huang, SK; Wang, HC1
He, X; Li, Z; Liu, D; Shi, J; Wu, Z; Xu, W; Yu, B; Zhou, R1
Almeida, M; Baptista, T; Graça, I; Henrique, R; Jerónimo, C; Palmeira, C; Ramalho-Carvalho, J; Sousa, EJ1
Diao, YF; Han, RX; Jin, DI; Li, XX; Lin, T; Naruse, KJ; Oqani, RK1
Chang, PK; Charron, F; Dezsi, G; Gill, R; Huang, TC; Jones, NC; Machnes, ZM; McKinney, RA; O'Brien, TJ; Ozturk, E; Reist, N; Szyf, M1
Maddox, SA; Schafe, GE; Watts, CS1
Borges, S; Döppler, HR; Storz, P1
Bredov, DV; Filatova, TS; Kozyrev, SA; Nikitin, PV; Nikitin, VP; Solntseva, SV1
Avrahami, D; Gerber, D; Ronen, M1
Levine, A; Sun, Y; Yi, L1
Kozyrev, SA; Nikitin, PV; Nikitin, VP; Solntseva, SV2
Carell, T; Frede, U; Hackner, B; Hagemeier, C; Maier, B; Penter, L; Truss, M1
Creighton, S; Kalisch, BE; Mitchnick, KA; O'Hara, M; Winters, BD1
Devine, SE; Hodes, GE; Lenz, KM; Mahurkar, A; McCarthy, MM; Nugent, BM; Russo, SJ; Shetty, AC; Wright, CL1
Barbier, E; Borich, A; Goldman, D; Heilig, M; Juergens, N; Pitcairn, C; Schank, JR; Schuebel, K; Sun, H; Tapocik, JD; Vendruscolo, LF; Yuan, Q; Zhou, Z1
Day, JJ; Guzman-Karlsson, MC; Hablitz, JJ; Holleman, C; Meadows, JP; Phillips, S; Posey, JL; Sweatt, JD1
Cho, GW; Kim, SH; Oh, YS1
Fan, C; Li, Z; Shi, L; Sun, L; Tang, B; Zhang, S; Zhang, X1
Eschenhagen, T; Hübner, F; Reichenspurner, H; Schaefer, A; Schneeberger, Y; Stenzig, J1
Biergans, SD; Claudianos, C; Giovanni Galizia, C; Reinhard, J1
Blasiak, J; Kaarniranta, K; Tokarz, P1
Eskow Jaunarajs, KL; Figge, DA; Standaert, DG1
Jiang, JR; Liu, QY; Lu, FH; Meng, LN; Shi, DS; Sun, HL; Zhao, X1
Dikmen, M1
Chen, X; Fu, X; Luo, J; Peng, X; Wang, L; Wang, X; Xiao, Z; Zhou, JX; Zhu, B1
Arimondo, PB; Dubois, J; Faux, C; Fleury, L; Masson, V; Rondelet, G; Willems, L; Wouters, J1
Cui, XH; Hou, J; Lv, YW; Suo, LN; Yang, L1
Liu, C; Lu, X; Lu, Z; Ou, Y; Tang, Y; Zhang, Q; Zhou, X1
Eschenhagen, T; Foo, RS; Geertz, B; Hirt, MN; Höppner, G; Löser, A; Ng, SL; Peters, BS; Reichenspurner, H; Schaefer, A; Schneeberger, Y; Stenzig, J; Tan, W; Wong, E; Zhao, RR1
Chen, SJ; Li, GS; Li, SY; Mai, HF; Wu, HC; Zhen, JX1
Bao, Y; Chen, X; Fu, X; Wang, L; Wang, X; Xiao, Z; Zhou, J1
An, X; Li, Q; Li, Z; Ma, X; Su, L; Yao, G; Yu, H; Zhai, Y; Zhang, S; Zhang, Z1
Dong, E; Gatta, E; Grayson, DR; Guidotti, A; Locci, V1
Kozyrev, SA; Nikitin, VP; Solntseva, SV1
Andia, DC; Assis, RIF; Casati, MZ; da Silva, RA; Feltran, GDS; Nociti, FH; Sallum, EA; Silvério, KG; Wiench, M1
Argyrousi, EK; de Nijs, L; Joca, SRL; Lagatta, DC; Prickaerts, J; Schlütter, A; van den Hove, DLA; van Goethem, NP; Weidner, MT; Zöller, J1
Adachi, H; Hashizume, A; Iida, M; Kataoka, M; Katsuno, M; Koike, H; Kondo, N; Kondo, Y; Nakatsuji, H; Sahashi, K; Shinjo, K; Sobue, G; Tohnai, G; Tsutsumi, Y1
Ashurov, D; Cunha, C; Mayilvahanan, K; Todorov, G1
Dai, JJ; Liu, Y; Sun, L; Wu, CF; Zhang, DF; Zhang, S1
Chen, X; Dai, L; Gao, H; Gao, S; Han, Y; Lei, Z; Wang, X; Wang, Z; Wu, H1
Bai, J; Fan, L; Gao, Z; Guo, L; Ning, B; Peng, Y; Wei, H1
An, X; Li, Q; Man, X; Zhai, Y; Zhang, S1
Cao, Z; Cheng, Q; Gong, C; Ruan, M; Xu, L; Zhang, Q1
Abreu, K; Cao, Q; Cheng, J; Chitaman, JM; Dietz, DM; Duffney, LJ; Feng, J; Jasrotia, RS; Liu, A; Pang, X; Waddell, NJ; Wang, ZJ; Wei, J; Yan, Z; Zhang, J1
Cai, C; He, Y; Li, W; Liu, C; Nie, G; Zeng, S; Zhao, L; Zheng, Z1
Andia, DC; Assis, RIF; da Silva, RA; Nociti, FH; Pecorari, VG; Racca, F; Schmidt, AG; Silvério, KG; Wiench, M; Zambuzzi, WF1
Beizer, A; Belitsky, G; Bugaeva, P; Fedorov, D; Katz, R; Kirsanov, K; Lesovaya, E; Lizogub, O; Maksimova, V; Shalginskikh, N; Usalka, O; Vlasova, O; Yakubovskaya, M1
Dikmen, M; Kaya-Tilki, E1

Other Studies

59 other study(ies) available for tryptophan and rg108

ArticleYear
Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.
    Journal of medicinal chemistry, 2014, Jan-23, Volume: 57, Issue:2

    Topics: Catalytic Domain; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Humans; Molecular Docking Simulation; Phthalic Acids; Phthalimides; Stereoisomerism; Structure-Activity Relationship; Tryptophan

2014
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.
    Cancer research, 2005, Jul-15, Volume: 65, Issue:14

    Topics: Binding Sites; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HCT116 Cells; Humans; Indoles; Phthalimides; Propionates; Tryptophan

2005
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
    Cancer research, 2006, Mar-01, Volume: 66, Issue:5

    Topics: Azacitidine; Catechin; Cell Line, Tumor; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Humans; Indoles; Jurkat Cells; Phthalimides; Procaine; Propionates; Tryptophan

2006
Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors.
    Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3

    Topics: Crystallography, X-Ray; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Design; Humans; Indoles; Maleimides; Phthalimides; Propionates; Protein Binding; Tryptophan

2010
Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Animals; Biomarkers; Cell Differentiation; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Embryonic Stem Cells; Heart Function Tests; Indoles; Induced Pluripotent Stem Cells; Male; Mice; MicroRNAs; Myoblasts, Skeletal; Myocardial Contraction; Myocardial Infarction; Myocardium; Oligonucleotide Array Sequence Analysis; Phthalimides; Propionates; Stem Cell Transplantation; Teratoma; Tryptophan; Ventricular Remodeling; Viruses

2011
Epigenetic regulation of motor neuron cell death through DNA methylation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation

2011
Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells.
    Cellular & molecular biology letters, 2012, Volume: 17, Issue:4

    Topics: Acetylation; Cadherins; CD11b Antigen; Cell Differentiation; Cell Proliferation; CpG Islands; Cytidine; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; HL-60 Cells; Humans; Indoles; Leukemia, Promyelocytic, Acute; Methylation; Phthalimides; Promoter Regions, Genetic; Propionates; Tretinoin; Tryptophan

2012
DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling.
    Cell biology international, 2012, Nov-01, Volume: 36, Issue:11

    Topics: Anilides; Biomarkers; Cadherins; CD11b Antigen; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chromatin Assembly and Disassembly; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Granulocytes; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Indoles; Phenylbutyrates; Phthalimides; Propionates; Time Factors; Transcriptional Activation; Tretinoin; Tryptophan

2012
Vitamin C promotes maturation of T-cells.
    Antioxidants & redox signaling, 2013, Dec-10, Volume: 19, Issue:17

    Topics: Animals; Ascorbic Acid; Azepines; Cells, Cultured; Culture Media; Epigenesis, Genetic; Gene Expression; Gene Rearrangement, T-Lymphocyte; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Immunologic Factors; Methylation; Mice; Mice, Inbred C57BL; Phthalimides; Protein Processing, Post-Translational; Quinazolines; Receptors, Antigen, T-Cell; T-Lymphocytes; Tryptophan

2013
Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood.
    Acta neurobiologiae experimentalis, 2012, Volume: 72, Issue:4

    Topics: Cell Differentiation; Cells, Cultured; Cellular Reprogramming; DNA Methylation; Enzyme Inhibitors; Fetal Blood; Gene Expression Regulation; Germ Layers; Humans; Hydroxamic Acids; Indoles; Induced Pluripotent Stem Cells; Karyotyping; Oxygen; Phthalimides; Pluripotent Stem Cells; Propionates; Time Factors; Transcription Factors; Transfection; Tryptophan

2012
Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2013, Volume: 115, Issue:3

    Topics: Blotting, Western; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tumor; Cells, Cultured; CpG Islands; DNA Methylation; Down-Regulation; Exons; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Vectors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Indoles; Keratinocytes; Molecular Chaperones; Mouth Mucosa; Mouth Neoplasms; Phthalimides; Plasmids; Promoter Regions, Genetic; Propionates; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tryptophan

2013
Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Animals; Biomarkers; Blastocyst; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histone Deacetylases; Homeodomain Proteins; Hydroxylamines; Indoles; Nuclear Transfer Techniques; Phthalimides; Propionates; Quinolines; RNA, Long Noncoding; Swine; Transcription, Genetic; Tryptophan

2013
Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.
    Current pharmaceutical design, 2014, Volume: 20, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Phthalimides; Promoter Regions, Genetic; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tryptophan

2014
Treatment of fetal fibroblasts with DNA methylation inhibitors and/or histone deacetylase inhibitors improves the development of porcine nuclear transfer-derived embryos.
    Animal reproduction science, 2013, Volume: 141, Issue:3-4

    Topics: Animals; Cloning, Organism; Cytidine; DNA Methylation; Embryo Culture Techniques; Embryonic Development; Epigenomics; Fibroblasts; Histone Deacetylase Inhibitors; Nuclear Transfer Techniques; Phthalimides; Swine; Tryptophan

2013
DNA methylation mediates persistent epileptiform activity in vitro and in vivo.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: 5' Flanking Region; Animals; Cell Line; CpG Islands; DNA Methylation; Epilepsy; Gene Order; Genetic Association Studies; Hippocampus; Humans; Kainic Acid; Male; Membrane Potentials; Mice; Neurons; Phenotype; Phthalimides; Promoter Regions, Genetic; Rats; Receptors, AMPA; Seizures; Tryptophan

2013
DNA methyltransferase activity is required for memory-related neural plasticity in the lateral amygdala.
    Neurobiology of learning and memory, 2014, Volume: 107

    Topics: Acoustic Stimulation; Amygdala; Animals; Azacitidine; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Fear; Male; Memory; Mental Recall; Neuronal Plasticity; Phthalimides; Rats; Rats, Sprague-Dawley; Tryptophan

2014
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
    Breast cancer research and treatment, 2014, Volume: 144, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Nude; Neoplasm Invasiveness; Phthalimides; Reverse Transcriptase Polymerase Chain Reaction; Suramin; Tryptophan; Xenograft Model Antitumor Assays

2014
Processes of DNA methylation are involved in the mechanisms of amnesia induction and conditioned food aversion memory reconsolidation.
    Bulletin of experimental biology and medicine, 2014, Volume: 156, Issue:4

    Topics: Amnesia; Animals; Conditioning, Psychological; Cytidine; Dizocilpine Maleate; DNA Methylation; DNA-Cytosine Methylases; Helix, Snails; Learning; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan

2014
A sensitive microfluidic platform for a high throughput DNA methylation assay.
    Lab on a chip, 2014, Jul-07, Volume: 14, Issue:13

    Topics: Aminoquinolines; Bacterial Proteins; DNA; DNA Methylation; DNA-Cytosine Methylases; Epigenesis, Genetic; Microfluidic Analytical Techniques; Phthalimides; Pyrimidines; Tryptophan

2014
Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells.
    Oncotarget, 2014, Oct-15, Volume: 5, Issue:19

    Topics: Animals; Anticarcinogenic Agents; Azacitidine; Catechin; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neoplasm Transplantation; Phthalimides; Tryptophan; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2014
The role of DNA methylation in the mechanisms of memory reconsolidation and development of amnesia.
    Behavioural brain research, 2015, Feb-15, Volume: 279

    Topics: Amnesia; Animals; Avoidance Learning; Cytidine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Helix, Snails; Memory, Long-Term; Phthalimides; Tryptophan

2015
A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.
    Targeted oncology, 2015, Volume: 10, Issue:4

    Topics: Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Modification Methylases; Doxorubicin; Drug Synergism; Enzyme Inhibitors; F-Box Proteins; HEK293 Cells; Humans; Molecular Targeted Therapy; Naphthoquinones; Neuroblastoma; Phthalimides; Pyrimidines; RNA, Small Interfering; Tryptophan

2015
Differential contributions of de novo and maintenance DNA methyltransferases to object memory processing in the rat hippocampus and perirhinal cortex--a double dissociation.
    The European journal of neuroscience, 2015, Volume: 41, Issue:6

    Topics: Animals; Cerebral Cortex; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Modification Methylases; Hippocampus; Male; Memory, Long-Term; Phthalimides; Rats; Rats, Long-Evans; Tryptophan

2015
Brain feminization requires active repression of masculinization via DNA methylation.
    Nature neuroscience, 2015, Volume: 18, Issue:5

    Topics: Animals; Brain; Copulation; CpG Islands; Cytidine; Disorders of Sex Development; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA, Intergenic; Estradiol; Female; Gene Expression Regulation, Developmental; Male; Mice; Microfilament Proteins; Nerve Tissue Proteins; Phthalimides; Preoptic Area; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation; Testosterone; Tryptophan

2015
DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-15, Volume: 35, Issue:15

    Topics: Alcoholism; Animals; Choice Behavior; Conditioning, Operant; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Ethanol; Gene Expression Profiling; Male; Methyltransferases; Nerve Tissue Proteins; Neuronal Plasticity; Phthalimides; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Statistics, Nonparametric; Synaptotagmin II; Transduction, Genetic; Tryptophan

2015
DNA methylation regulates neuronal glutamatergic synaptic scaling.
    Science signaling, 2015, Jun-23, Volume: 8, Issue:382

    Topics: Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Gene Knockdown Techniques; Neurons; Phthalimides; Rats; Synapses; Synaptic Potentials; Tetrodotoxin; Transcription, Genetic; Tryptophan

2015
Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.
    Cellular and molecular neurobiology, 2016, Volume: 36, Issue:4

    Topics: Amyotrophic Lateral Sclerosis; Cell Differentiation; Cell Movement; Cellular Senescence; DNA Modification Methylases; Humans; Mesenchymal Stem Cells; Neurons; Neuroprotection; Phthalimides; Tryptophan

2016
Effect of DNMT inhibitor on bovine parthenogenetic embryo development.
    Biochemical and biophysical research communications, 2015, Oct-23, Volume: 466, Issue:3

    Topics: Animals; Apoptosis; Cattle; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryonic Development; Enzyme Inhibitors; Female; Homeodomain Proteins; In Vitro Techniques; Parthenogenesis; Phthalimides; Pregnancy; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic; Tryptophan

2015
Pharmacokinetics of the Experimental Non-Nucleosidic DNA Methyl Transferase Inhibitor N-Phthalyl-L-Tryptophan (RG 108) in Rats.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 118, Issue:5

    Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; DNA Modification Methylases; Enzyme Inhibitors; Half-Life; Inhibitory Concentration 50; Injections, Subcutaneous; Male; Mass Spectrometry; Phthalimides; Rats; Rats, Wistar; Time Factors; Tryptophan

2016
Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees.
    Scientific reports, 2015, Nov-04, Volume: 5

    Topics: Animals; Bees; Cyclic AMP Response Element-Binding Protein; Cytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Memory, Long-Term; Phthalimides; Smell; Tryptophan; Up-Regulation

2015
Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes.
    European journal of pharmacology, 2016, Apr-05, Volume: 776

    Topics: Antioxidants; Cell Line; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Repair; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; M Phase Cell Cycle Checkpoints; Oxidative Stress; Phthalimides; Reactive Oxygen Species; Retinal Pigment Epithelium; Time Factors; Tryptophan; Valproic Acid

2016
Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 06-15, Volume: 36, Issue:24

    Topics: Analysis of Variance; Animals; Antiparkinson Agents; Corpus Striatum; Dioxygenases; Disease Models, Animal; DNA Methylation; Dopamine; Dyskinesia, Drug-Induced; Enzyme Inhibitors; GADD45 Proteins; Gene Expression Regulation; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Phthalimides; Rats; Rats, Sprague-Dawley; Tryptophan

2016
Effects of DNA methyltransferase inhibitor RG108 on methylation in buffalo adult fibroblasts and subsequent embryonic development following somatic cell nuclear transfer.
    Genetics and molecular research : GMR, 2016, Sep-02, Volume: 15, Issue:3

    Topics: Animals; Blastocyst; Breeding; Buffaloes; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Epigenesis, Genetic; Female; Fertilization in Vitro; Fibroblasts; Male; Nuclear Transfer Techniques; Oocytes; Phthalimides; Pregnancy; Spermatozoa; Tryptophan

2016
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth.
    Journal of medicinal food, 2017, Volume: 20, Issue:4

    Topics: Animals; Cell Differentiation; Curcumin; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; GAP-43 Protein; Gene Expression; Nerve Growth Factor; Neurites; Neuronal Outgrowth; PC12 Cells; Phthalimides; Rats; Tryptophan; Tubulin

2017
Association of RASgrf1 methylation with epileptic seizures.
    Oncotarget, 2017, Jul-11, Volume: 8, Issue:28

    Topics: Animals; Brain; Disease Models, Animal; DNA Methylation; Epilepsy; Gene Expression; Genetic Association Studies; Genetic Predisposition to Disease; Male; Mice; Mice, Knockout; Phthalimides; Pyramidal Cells; ras-GRF1; Seizures; Tryptophan

2017
Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.
    Future medicinal chemistry, 2017, Volume: 9, Issue:13

    Topics: Animals; Apoenzymes; Binding Sites; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Fluorometry; Humans; Inhibitory Concentration 50; Maleimides; Mice; Molecular Docking Simulation; Phthalimides; Protein Structure, Tertiary; Recombinant Proteins; Tryptophan

2017
RG108 induces the apoptosis of endometrial cancer Ishikawa cell lines by inhibiting the expression of DNMT3B and demethylation of HMLH1.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:22

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Demethylation; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Endometrial Neoplasms; Female; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MutL Protein Homolog 1; Phthalimides; Tryptophan

2017
DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer.
    Oncology reports, 2018, Volume: 39, Issue:3

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; DNA Methylation; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phthalimides; Radiation Tolerance; Tryptophan; Tumor Cells, Cultured; X-Rays; Xenograft Model Antitumor Assays

2018
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.
    Journal of molecular and cellular cardiology, 2018, Volume: 120

    Topics: Analysis of Variance; Animals; Cardiomegaly; CpG Islands; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Fibrosis; Gene Expression Regulation; Heart Failure; Magnetic Resonance Imaging; Male; Myocardium; Myocytes, Cardiac; Phthalimides; Rats; Rats, Wistar; Sequence Analysis, RNA; Thoracic Arteries; Tryptophan; Ventricular Function

2018
Microarray-based analysis of whole-genome DNA methylation profiling in early detection of breast cancer.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:1

    Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Databases, Nucleic Acid; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Early Detection of Cancer; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Homeodomain Proteins; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Middle Aged; Oligonucleotide Array Sequence Analysis; Phthalimides; Signal Transduction; Transcription Factors; Transcriptome; Tryptophan; Up-Regulation

2019
RASgrf1, a Potential Methylatic Mediator of Anti-epileptogenesis?
    Neurochemical research, 2018, Volume: 43, Issue:10

    Topics: Animals; Disease Models, Animal; DNA Methylation; Electroencephalography; Gene Expression; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Phthalimides; Promoter Regions, Genetic; ras-GRF1; Status Epilepticus; Tryptophan

2018
Dynamic Methylation Changes of DNA and H3K4 by RG108 Improve Epigenetic Reprogramming of Somatic Cell Nuclear Transfer Embryos in Pigs.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 50, Issue:4

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blastocyst; Cellular Reprogramming; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Histones; Mixed Function Oxygenases; Nuclear Transfer Techniques; Phthalimides; Protein Processing, Post-Translational; Swine; Tryptophan

2018
    Molecular pharmacology, 2019, Volume: 95, Issue:1

    Topics: Animals; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic Factor; Cell Adhesion Molecules, Neuronal; Chromatin; Chromatin Assembly and Disassembly; Clozapine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Female; Glutamate Decarboxylase; Male; Mental Disorders; Mice; Nerve Tissue Proteins; Phthalimides; Pregnancy; Prenatal Exposure Delayed Effects; Promoter Regions, Genetic; Reelin Protein; Serine Endopeptidases; Tryptophan

2019
Peculiarities of Participation of DNA Methyltransferases in the Mechanisms of Storage, Impairment, and Recovery of Conditioned Food Aversion Memory.
    Bulletin of experimental biology and medicine, 2018, Volume: 166, Issue:1

    Topics: Amnesia; Animals; DNA Modification Methylases; Helix, Snails; Memory; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan; Valine

2018
RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation.
    PloS one, 2018, Volume: 13, Issue:12

    Topics: Apoptosis; Biomarkers; Cell Survival; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Endoglin; Epigenesis, Genetic; Humans; Mesenchymal Stem Cells; Mixed Function Oxygenases; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phthalimides; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Messenger; Tryptophan

2018
Effects of DNA methyltransferase inhibition on pattern separation performance in mice.
    Neurobiology of learning and memory, 2019, Volume: 159

    Topics: Animals; Behavior, Animal; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Epigenesis, Genetic; Exploratory Behavior; Gene Expression; Hippocampus; Memory, Long-Term; Memory, Short-Term; Mice; Minute Virus of Mice; Neuronal Plasticity; Phthalimides; Promoter Regions, Genetic; Space Perception; Tryptophan

2019
DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.
    EMBO molecular medicine, 2019, Volume: 11, Issue:5

    Topics: Aged; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Humans; Mice, Inbred C57BL; Middle Aged; Models, Biological; Motor Activity; Motor Neurons; Muscular Atrophy, Spinal; Nerve Degeneration; Peptides; Phthalimides; Promoter Regions, Genetic; Receptors, Androgen; Repressor Proteins; Smad2 Protein; Spinal Cord; Tryptophan

2019
Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism.
    Scientific reports, 2019, 06-19, Volume: 9, Issue:1

    Topics: Animals; Compulsive Behavior; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Mice; Obsessive-Compulsive Disorder; Phthalimides; Tryptophan

2019
Optimizing treatment of DNA methyltransferase inhibitor RG108 on porcine fibroblasts for somatic cell nuclear transfer.
    Reproduction in domestic animals = Zuchthygiene, 2019, Volume: 54, Issue:12

    Topics: Animals; Blastocyst; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fibroblasts; Histones; Nuclear Transfer Techniques; Phthalimides; Swine; Tryptophan

2019
Epigenetic modulation of glycoprotein VI gene expression by DNA methylation.
    Life sciences, 2020, Jan-15, Volume: 241

    Topics: Case-Control Studies; Cells, Cultured; Coronary Disease; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Megakaryocytes; Phthalimides; Platelet Membrane Glycoproteins; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Tryptophan

2020
A tri-functional probe mediated exponential amplification strategy for highly sensitive detection of Dnmt1 and UDG activities at single-cell level.
    Analytica chimica acta, 2020, Mar-22, Volume: 1103

    Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA Probes; DNA, Single-Stranded; Enzyme Assays; Humans; Limit of Detection; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Phthalimides; Single-Cell Analysis; Tryptophan; Uracil-DNA Glycosidase

2020
Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.
    Cellular reprogramming, 2020, Volume: 22, Issue:2

    Topics: Animals; Apoptosis; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Cellular Senescence; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression Regulation; Mesenchymal Stem Cells; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phthalimides; Real-Time Polymerase Chain Reaction; Swine; Tryptophan

2020
Development of a kind of RG108-Fluorescein conjugates for detection of DNA methyltransferase 1 (DNMT1) in living cells.
    Analytical biochemistry, 2020, 10-15, Volume: 607

    Topics: DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Female; Fluorescein; Fluorescent Dyes; HeLa Cells; Humans; Molecular Docking Simulation; Phthalimides; Protein Binding; Protein Processing, Post-Translational; Tryptophan; Uterine Cervical Neoplasms

2020
DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors.
    Cerebral cortex (New York, N.Y. : 1991), 2021, 03-05, Volume: 31, Issue:4

    Topics: Animals; Chronic Disease; DNA Methyltransferase 3A; Exploratory Behavior; Locomotion; Male; Mice; Phthalimides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Psychological; Synapses; Tryptophan

2021
Learning against the Background of DNA Methyltransferase Inhibition Leads to the Formation of Memory That Is Resistant to Reactivation and Impairment.
    Bulletin of experimental biology and medicine, 2021, Volume: 170, Issue:3

    Topics: Animals; Dizocilpine Maleate; Memory; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan

2021
The DNA methylation inhibitor RG108 protects against noise-induced hearing loss.
    Cell biology and toxicology, 2021, Volume: 37, Issue:5

    Topics: Animals; Auditory Threshold; DNA Methylation; Hearing Loss, Noise-Induced; Mice; Phthalimides; Quality of Life; Tryptophan

2021
DNMT1 Inhibitor Restores RUNX2 Expression and Mineralization in Periodontal Ligament Cells.
    DNA and cell biology, 2021, Volume: 40, Issue:5

    Topics: Calcification, Physiologic; Cell Nucleus; Core Binding Factor Alpha 1 Subunit; DNA (Cytosine-5-)-Methyltransferase 1; Down-Regulation; Enzyme Inhibitors; Humans; Osteogenesis; Periodontal Ligament; Phthalimides; Tryptophan; Up-Regulation; Young Adult

2021
HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes.
    PloS one, 2021, Volume: 16, Issue:6

    Topics: Azacitidine; Azepines; DNA Methylation; Epigenesis, Genetic; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Phthalimides; Quinazolines; Tryptophan

2021
Neuroprotective effects of some epigenetic modifying drugs' on Chlamydia pneumoniae-induced neuroinflammation: A novel model.
    PloS one, 2021, Volume: 16, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Chlamydophila Infections; Chlamydophila pneumoniae; Epigenesis, Genetic; Humans; Hydroxamic Acids; Inflammation; Neuroprotective Agents; Peptide Fragments; Phthalimides; THP-1 Cells; Tryptophan

2021