tryptophan and rg108
tryptophan has been researched along with rg108 in 59 studies
Research
Studies (59)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (3.39) | 29.6817 |
| 2010's | 47 (79.66) | 24.3611 |
| 2020's | 10 (16.95) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Arimondo, PB; Asgatay, S; Ceccaldi, A; Champion, C; Drujon, T; Erdmann, A; Guianvarc'h, D; Jeltsch, A; Karoyan, P; Lequin, O; Marloie, G; Rajavelu, A; Schambel, P; Senamaud-Beaufort, C | 1 |
| Brueckner, B; Garcia Boy, R; Kliem, HC; Lyko, F; Musch, T; Siedlecki, P; Suhai, S; Wiessler, M; Zielenkiewicz, P | 1 |
| Brueckner, B; Lyko, F; Musch, T; Stopper, H; Stresemann, C | 1 |
| Hamada, S; Miyata, N; Nakagawa, H; Suzuki, T; Tanaka, R | 1 |
| Ashraf, M; Haider, HKh; Pasha, Z | 1 |
| Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M | 1 |
| Borutinskaite, VV; Navakauskiene, R; Savickiene, J; Treigyte, G | 1 |
| Borutinskaite, VV; Jazdauskaite, A; Navakauskiene, R; Savickiene, J; Treigyte, G | 1 |
| Appadurai, DA; Manning, J; May, JM; Mitchell, B; Nganga, V; Pierce, LJ; Shakya, A; Spangrude, GJ; Swanson, PC; Tantin, D; Wang, H | 1 |
| Buzanska, L; Pastwinska, A; Pienkowska-Grela, B; Podobinska, M; Sypecka, J; Szablowska-Gadomska, I; Zayat, V | 1 |
| Chiang, HC; Chiang, WF; Huang, HH; Huang, SK; Wang, HC | 1 |
| He, X; Li, Z; Liu, D; Shi, J; Wu, Z; Xu, W; Yu, B; Zhou, R | 1 |
| Almeida, M; Baptista, T; Graça, I; Henrique, R; Jerónimo, C; Palmeira, C; Ramalho-Carvalho, J; Sousa, EJ | 1 |
| Diao, YF; Han, RX; Jin, DI; Li, XX; Lin, T; Naruse, KJ; Oqani, RK | 1 |
| Chang, PK; Charron, F; Dezsi, G; Gill, R; Huang, TC; Jones, NC; Machnes, ZM; McKinney, RA; O'Brien, TJ; Ozturk, E; Reist, N; Szyf, M | 1 |
| Maddox, SA; Schafe, GE; Watts, CS | 1 |
| Borges, S; Döppler, HR; Storz, P | 1 |
| Bredov, DV; Filatova, TS; Kozyrev, SA; Nikitin, PV; Nikitin, VP; Solntseva, SV | 1 |
| Avrahami, D; Gerber, D; Ronen, M | 1 |
| Levine, A; Sun, Y; Yi, L | 1 |
| Kozyrev, SA; Nikitin, PV; Nikitin, VP; Solntseva, SV | 2 |
| Carell, T; Frede, U; Hackner, B; Hagemeier, C; Maier, B; Penter, L; Truss, M | 1 |
| Creighton, S; Kalisch, BE; Mitchnick, KA; O'Hara, M; Winters, BD | 1 |
| Devine, SE; Hodes, GE; Lenz, KM; Mahurkar, A; McCarthy, MM; Nugent, BM; Russo, SJ; Shetty, AC; Wright, CL | 1 |
| Barbier, E; Borich, A; Goldman, D; Heilig, M; Juergens, N; Pitcairn, C; Schank, JR; Schuebel, K; Sun, H; Tapocik, JD; Vendruscolo, LF; Yuan, Q; Zhou, Z | 1 |
| Day, JJ; Guzman-Karlsson, MC; Hablitz, JJ; Holleman, C; Meadows, JP; Phillips, S; Posey, JL; Sweatt, JD | 1 |
| Cho, GW; Kim, SH; Oh, YS | 1 |
| Fan, C; Li, Z; Shi, L; Sun, L; Tang, B; Zhang, S; Zhang, X | 1 |
| Eschenhagen, T; Hübner, F; Reichenspurner, H; Schaefer, A; Schneeberger, Y; Stenzig, J | 1 |
| Biergans, SD; Claudianos, C; Giovanni Galizia, C; Reinhard, J | 1 |
| Blasiak, J; Kaarniranta, K; Tokarz, P | 1 |
| Eskow Jaunarajs, KL; Figge, DA; Standaert, DG | 1 |
| Jiang, JR; Liu, QY; Lu, FH; Meng, LN; Shi, DS; Sun, HL; Zhao, X | 1 |
| Dikmen, M | 1 |
| Chen, X; Fu, X; Luo, J; Peng, X; Wang, L; Wang, X; Xiao, Z; Zhou, JX; Zhu, B | 1 |
| Arimondo, PB; Dubois, J; Faux, C; Fleury, L; Masson, V; Rondelet, G; Willems, L; Wouters, J | 1 |
| Cui, XH; Hou, J; Lv, YW; Suo, LN; Yang, L | 1 |
| Liu, C; Lu, X; Lu, Z; Ou, Y; Tang, Y; Zhang, Q; Zhou, X | 1 |
| Eschenhagen, T; Foo, RS; Geertz, B; Hirt, MN; Höppner, G; Löser, A; Ng, SL; Peters, BS; Reichenspurner, H; Schaefer, A; Schneeberger, Y; Stenzig, J; Tan, W; Wong, E; Zhao, RR | 1 |
| Chen, SJ; Li, GS; Li, SY; Mai, HF; Wu, HC; Zhen, JX | 1 |
| Bao, Y; Chen, X; Fu, X; Wang, L; Wang, X; Xiao, Z; Zhou, J | 1 |
| An, X; Li, Q; Li, Z; Ma, X; Su, L; Yao, G; Yu, H; Zhai, Y; Zhang, S; Zhang, Z | 1 |
| Dong, E; Gatta, E; Grayson, DR; Guidotti, A; Locci, V | 1 |
| Kozyrev, SA; Nikitin, VP; Solntseva, SV | 1 |
| Andia, DC; Assis, RIF; Casati, MZ; da Silva, RA; Feltran, GDS; Nociti, FH; Sallum, EA; Silvério, KG; Wiench, M | 1 |
| Argyrousi, EK; de Nijs, L; Joca, SRL; Lagatta, DC; Prickaerts, J; Schlütter, A; van den Hove, DLA; van Goethem, NP; Weidner, MT; Zöller, J | 1 |
| Adachi, H; Hashizume, A; Iida, M; Kataoka, M; Katsuno, M; Koike, H; Kondo, N; Kondo, Y; Nakatsuji, H; Sahashi, K; Shinjo, K; Sobue, G; Tohnai, G; Tsutsumi, Y | 1 |
| Ashurov, D; Cunha, C; Mayilvahanan, K; Todorov, G | 1 |
| Dai, JJ; Liu, Y; Sun, L; Wu, CF; Zhang, DF; Zhang, S | 1 |
| Chen, X; Dai, L; Gao, H; Gao, S; Han, Y; Lei, Z; Wang, X; Wang, Z; Wu, H | 1 |
| Bai, J; Fan, L; Gao, Z; Guo, L; Ning, B; Peng, Y; Wei, H | 1 |
| An, X; Li, Q; Man, X; Zhai, Y; Zhang, S | 1 |
| Cao, Z; Cheng, Q; Gong, C; Ruan, M; Xu, L; Zhang, Q | 1 |
| Abreu, K; Cao, Q; Cheng, J; Chitaman, JM; Dietz, DM; Duffney, LJ; Feng, J; Jasrotia, RS; Liu, A; Pang, X; Waddell, NJ; Wang, ZJ; Wei, J; Yan, Z; Zhang, J | 1 |
| Cai, C; He, Y; Li, W; Liu, C; Nie, G; Zeng, S; Zhao, L; Zheng, Z | 1 |
| Andia, DC; Assis, RIF; da Silva, RA; Nociti, FH; Pecorari, VG; Racca, F; Schmidt, AG; Silvério, KG; Wiench, M; Zambuzzi, WF | 1 |
| Beizer, A; Belitsky, G; Bugaeva, P; Fedorov, D; Katz, R; Kirsanov, K; Lesovaya, E; Lizogub, O; Maksimova, V; Shalginskikh, N; Usalka, O; Vlasova, O; Yakubovskaya, M | 1 |
| Dikmen, M; Kaya-Tilki, E | 1 |
Other Studies
59 other study(ies) available for tryptophan and rg108
| Article | Year |
|---|---|
Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.
Topics: Catalytic Domain; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Humans; Molecular Docking Simulation; Phthalic Acids; Phthalimides; Stereoisomerism; Structure-Activity Relationship; Tryptophan | 2014 |
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.
Topics: Binding Sites; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HCT116 Cells; Humans; Indoles; Phthalimides; Propionates; Tryptophan | 2005 |
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Topics: Azacitidine; Catechin; Cell Line, Tumor; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Humans; Indoles; Jurkat Cells; Phthalimides; Procaine; Propionates; Tryptophan | 2006 |
Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors.
Topics: Crystallography, X-Ray; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Design; Humans; Indoles; Maleimides; Phthalimides; Propionates; Protein Binding; Tryptophan | 2010 |
Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells.
Topics: Animals; Biomarkers; Cell Differentiation; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Embryonic Stem Cells; Heart Function Tests; Indoles; Induced Pluripotent Stem Cells; Male; Mice; MicroRNAs; Myoblasts, Skeletal; Myocardial Contraction; Myocardial Infarction; Myocardium; Oligonucleotide Array Sequence Analysis; Phthalimides; Propionates; Stem Cell Transplantation; Teratoma; Tryptophan; Ventricular Remodeling; Viruses | 2011 |
Epigenetic regulation of motor neuron cell death through DNA methylation.
Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation | 2011 |
Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells.
Topics: Acetylation; Cadherins; CD11b Antigen; Cell Differentiation; Cell Proliferation; CpG Islands; Cytidine; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; HL-60 Cells; Humans; Indoles; Leukemia, Promyelocytic, Acute; Methylation; Phthalimides; Promoter Regions, Genetic; Propionates; Tretinoin; Tryptophan | 2012 |
DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling.
Topics: Anilides; Biomarkers; Cadherins; CD11b Antigen; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chromatin Assembly and Disassembly; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Granulocytes; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Indoles; Phenylbutyrates; Phthalimides; Propionates; Time Factors; Transcriptional Activation; Tretinoin; Tryptophan | 2012 |
Vitamin C promotes maturation of T-cells.
Topics: Animals; Ascorbic Acid; Azepines; Cells, Cultured; Culture Media; Epigenesis, Genetic; Gene Expression; Gene Rearrangement, T-Lymphocyte; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Immunologic Factors; Methylation; Mice; Mice, Inbred C57BL; Phthalimides; Protein Processing, Post-Translational; Quinazolines; Receptors, Antigen, T-Cell; T-Lymphocytes; Tryptophan | 2013 |
Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood.
Topics: Cell Differentiation; Cells, Cultured; Cellular Reprogramming; DNA Methylation; Enzyme Inhibitors; Fetal Blood; Gene Expression Regulation; Germ Layers; Humans; Hydroxamic Acids; Indoles; Induced Pluripotent Stem Cells; Karyotyping; Oxygen; Phthalimides; Pluripotent Stem Cells; Propionates; Time Factors; Transcription Factors; Transfection; Tryptophan | 2012 |
Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells.
Topics: Blotting, Western; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tumor; Cells, Cultured; CpG Islands; DNA Methylation; Down-Regulation; Exons; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Vectors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Indoles; Keratinocytes; Molecular Chaperones; Mouth Mucosa; Mouth Neoplasms; Phthalimides; Plasmids; Promoter Regions, Genetic; Propionates; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tryptophan | 2013 |
Effects of DNMT1 and HDAC inhibitors on gene-specific methylation reprogramming during porcine somatic cell nuclear transfer.
Topics: Animals; Biomarkers; Blastocyst; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histone Deacetylases; Homeodomain Proteins; Hydroxylamines; Indoles; Nuclear Transfer Techniques; Phthalimides; Propionates; Quinolines; RNA, Long Noncoding; Swine; Transcription, Genetic; Tryptophan | 2013 |
Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Phthalimides; Promoter Regions, Genetic; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tryptophan | 2014 |
Treatment of fetal fibroblasts with DNA methylation inhibitors and/or histone deacetylase inhibitors improves the development of porcine nuclear transfer-derived embryos.
Topics: Animals; Cloning, Organism; Cytidine; DNA Methylation; Embryo Culture Techniques; Embryonic Development; Epigenomics; Fibroblasts; Histone Deacetylase Inhibitors; Nuclear Transfer Techniques; Phthalimides; Swine; Tryptophan | 2013 |
DNA methylation mediates persistent epileptiform activity in vitro and in vivo.
Topics: 5' Flanking Region; Animals; Cell Line; CpG Islands; DNA Methylation; Epilepsy; Gene Order; Genetic Association Studies; Hippocampus; Humans; Kainic Acid; Male; Membrane Potentials; Mice; Neurons; Phenotype; Phthalimides; Promoter Regions, Genetic; Rats; Receptors, AMPA; Seizures; Tryptophan | 2013 |
DNA methyltransferase activity is required for memory-related neural plasticity in the lateral amygdala.
Topics: Acoustic Stimulation; Amygdala; Animals; Azacitidine; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Fear; Male; Memory; Mental Recall; Neuronal Plasticity; Phthalimides; Rats; Rats, Sprague-Dawley; Tryptophan | 2014 |
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Nude; Neoplasm Invasiveness; Phthalimides; Reverse Transcriptase Polymerase Chain Reaction; Suramin; Tryptophan; Xenograft Model Antitumor Assays | 2014 |
Processes of DNA methylation are involved in the mechanisms of amnesia induction and conditioned food aversion memory reconsolidation.
Topics: Amnesia; Animals; Conditioning, Psychological; Cytidine; Dizocilpine Maleate; DNA Methylation; DNA-Cytosine Methylases; Helix, Snails; Learning; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2014 |
A sensitive microfluidic platform for a high throughput DNA methylation assay.
Topics: Aminoquinolines; Bacterial Proteins; DNA; DNA Methylation; DNA-Cytosine Methylases; Epigenesis, Genetic; Microfluidic Analytical Techniques; Phthalimides; Pyrimidines; Tryptophan | 2014 |
Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells.
Topics: Animals; Anticarcinogenic Agents; Azacitidine; Catechin; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neoplasm Transplantation; Phthalimides; Tryptophan; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
The role of DNA methylation in the mechanisms of memory reconsolidation and development of amnesia.
Topics: Amnesia; Animals; Avoidance Learning; Cytidine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Helix, Snails; Memory, Long-Term; Phthalimides; Tryptophan | 2015 |
A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.
Topics: Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Modification Methylases; Doxorubicin; Drug Synergism; Enzyme Inhibitors; F-Box Proteins; HEK293 Cells; Humans; Molecular Targeted Therapy; Naphthoquinones; Neuroblastoma; Phthalimides; Pyrimidines; RNA, Small Interfering; Tryptophan | 2015 |
Differential contributions of de novo and maintenance DNA methyltransferases to object memory processing in the rat hippocampus and perirhinal cortex--a double dissociation.
Topics: Animals; Cerebral Cortex; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Modification Methylases; Hippocampus; Male; Memory, Long-Term; Phthalimides; Rats; Rats, Long-Evans; Tryptophan | 2015 |
Brain feminization requires active repression of masculinization via DNA methylation.
Topics: Animals; Brain; Copulation; CpG Islands; Cytidine; Disorders of Sex Development; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA, Intergenic; Estradiol; Female; Gene Expression Regulation, Developmental; Male; Mice; Microfilament Proteins; Nerve Tissue Proteins; Phthalimides; Preoptic Area; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation; Testosterone; Tryptophan | 2015 |
DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.
Topics: Alcoholism; Animals; Choice Behavior; Conditioning, Operant; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Ethanol; Gene Expression Profiling; Male; Methyltransferases; Nerve Tissue Proteins; Neuronal Plasticity; Phthalimides; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Statistics, Nonparametric; Synaptotagmin II; Transduction, Genetic; Tryptophan | 2015 |
DNA methylation regulates neuronal glutamatergic synaptic scaling.
Topics: Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Gene Knockdown Techniques; Neurons; Phthalimides; Rats; Synapses; Synaptic Potentials; Tetrodotoxin; Transcription, Genetic; Tryptophan | 2015 |
Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.
Topics: Amyotrophic Lateral Sclerosis; Cell Differentiation; Cell Movement; Cellular Senescence; DNA Modification Methylases; Humans; Mesenchymal Stem Cells; Neurons; Neuroprotection; Phthalimides; Tryptophan | 2016 |
Effect of DNMT inhibitor on bovine parthenogenetic embryo development.
Topics: Animals; Apoptosis; Cattle; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryonic Development; Enzyme Inhibitors; Female; Homeodomain Proteins; In Vitro Techniques; Parthenogenesis; Phthalimides; Pregnancy; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic; Tryptophan | 2015 |
Pharmacokinetics of the Experimental Non-Nucleosidic DNA Methyl Transferase Inhibitor N-Phthalyl-L-Tryptophan (RG 108) in Rats.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; DNA Modification Methylases; Enzyme Inhibitors; Half-Life; Inhibitory Concentration 50; Injections, Subcutaneous; Male; Mass Spectrometry; Phthalimides; Rats; Rats, Wistar; Time Factors; Tryptophan | 2016 |
Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees.
Topics: Animals; Bees; Cyclic AMP Response Element-Binding Protein; Cytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Memory, Long-Term; Phthalimides; Smell; Tryptophan; Up-Regulation | 2015 |
Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes.
Topics: Antioxidants; Cell Line; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Repair; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; M Phase Cell Cycle Checkpoints; Oxidative Stress; Phthalimides; Reactive Oxygen Species; Retinal Pigment Epithelium; Time Factors; Tryptophan; Valproic Acid | 2016 |
Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Corpus Striatum; Dioxygenases; Disease Models, Animal; DNA Methylation; Dopamine; Dyskinesia, Drug-Induced; Enzyme Inhibitors; GADD45 Proteins; Gene Expression Regulation; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Phthalimides; Rats; Rats, Sprague-Dawley; Tryptophan | 2016 |
Effects of DNA methyltransferase inhibitor RG108 on methylation in buffalo adult fibroblasts and subsequent embryonic development following somatic cell nuclear transfer.
Topics: Animals; Blastocyst; Breeding; Buffaloes; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Epigenesis, Genetic; Female; Fertilization in Vitro; Fibroblasts; Male; Nuclear Transfer Techniques; Oocytes; Phthalimides; Pregnancy; Spermatozoa; Tryptophan | 2016 |
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth.
Topics: Animals; Cell Differentiation; Curcumin; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; GAP-43 Protein; Gene Expression; Nerve Growth Factor; Neurites; Neuronal Outgrowth; PC12 Cells; Phthalimides; Rats; Tryptophan; Tubulin | 2017 |
Association of RASgrf1 methylation with epileptic seizures.
Topics: Animals; Brain; Disease Models, Animal; DNA Methylation; Epilepsy; Gene Expression; Genetic Association Studies; Genetic Predisposition to Disease; Male; Mice; Mice, Knockout; Phthalimides; Pyramidal Cells; ras-GRF1; Seizures; Tryptophan | 2017 |
Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.
Topics: Animals; Apoenzymes; Binding Sites; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Fluorometry; Humans; Inhibitory Concentration 50; Maleimides; Mice; Molecular Docking Simulation; Phthalimides; Protein Structure, Tertiary; Recombinant Proteins; Tryptophan | 2017 |
RG108 induces the apoptosis of endometrial cancer Ishikawa cell lines by inhibiting the expression of DNMT3B and demethylation of HMLH1.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Demethylation; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Endometrial Neoplasms; Female; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MutL Protein Homolog 1; Phthalimides; Tryptophan | 2017 |
DNA methylation enzyme inhibitor RG108 suppresses the radioresistance of esophageal cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; DNA Methylation; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phthalimides; Radiation Tolerance; Tryptophan; Tumor Cells, Cultured; X-Rays; Xenograft Model Antitumor Assays | 2018 |
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.
Topics: Analysis of Variance; Animals; Cardiomegaly; CpG Islands; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Fibrosis; Gene Expression Regulation; Heart Failure; Magnetic Resonance Imaging; Male; Myocardium; Myocytes, Cardiac; Phthalimides; Rats; Rats, Wistar; Sequence Analysis, RNA; Thoracic Arteries; Tryptophan; Ventricular Function | 2018 |
Microarray-based analysis of whole-genome DNA methylation profiling in early detection of breast cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Databases, Nucleic Acid; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Early Detection of Cancer; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Homeodomain Proteins; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Middle Aged; Oligonucleotide Array Sequence Analysis; Phthalimides; Signal Transduction; Transcription Factors; Transcriptome; Tryptophan; Up-Regulation | 2019 |
RASgrf1, a Potential Methylatic Mediator of Anti-epileptogenesis?
Topics: Animals; Disease Models, Animal; DNA Methylation; Electroencephalography; Gene Expression; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Phthalimides; Promoter Regions, Genetic; ras-GRF1; Status Epilepticus; Tryptophan | 2018 |
Dynamic Methylation Changes of DNA and H3K4 by RG108 Improve Epigenetic Reprogramming of Somatic Cell Nuclear Transfer Embryos in Pigs.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blastocyst; Cellular Reprogramming; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Histones; Mixed Function Oxygenases; Nuclear Transfer Techniques; Phthalimides; Protein Processing, Post-Translational; Swine; Tryptophan | 2018 |
Topics: Animals; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic Factor; Cell Adhesion Molecules, Neuronal; Chromatin; Chromatin Assembly and Disassembly; Clozapine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Female; Glutamate Decarboxylase; Male; Mental Disorders; Mice; Nerve Tissue Proteins; Phthalimides; Pregnancy; Prenatal Exposure Delayed Effects; Promoter Regions, Genetic; Reelin Protein; Serine Endopeptidases; Tryptophan | 2019 |
Peculiarities of Participation of DNA Methyltransferases in the Mechanisms of Storage, Impairment, and Recovery of Conditioned Food Aversion Memory.
Topics: Amnesia; Animals; DNA Modification Methylases; Helix, Snails; Memory; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan; Valine | 2018 |
RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation.
Topics: Apoptosis; Biomarkers; Cell Survival; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Endoglin; Epigenesis, Genetic; Humans; Mesenchymal Stem Cells; Mixed Function Oxygenases; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phthalimides; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Messenger; Tryptophan | 2018 |
Effects of DNA methyltransferase inhibition on pattern separation performance in mice.
Topics: Animals; Behavior, Animal; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Epigenesis, Genetic; Exploratory Behavior; Gene Expression; Hippocampus; Memory, Long-Term; Memory, Short-Term; Mice; Minute Virus of Mice; Neuronal Plasticity; Phthalimides; Promoter Regions, Genetic; Space Perception; Tryptophan | 2019 |
DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.
Topics: Aged; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Humans; Mice, Inbred C57BL; Middle Aged; Models, Biological; Motor Activity; Motor Neurons; Muscular Atrophy, Spinal; Nerve Degeneration; Peptides; Phthalimides; Promoter Regions, Genetic; Receptors, Androgen; Repressor Proteins; Smad2 Protein; Spinal Cord; Tryptophan | 2019 |
Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism.
Topics: Animals; Compulsive Behavior; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Mice; Obsessive-Compulsive Disorder; Phthalimides; Tryptophan | 2019 |
Optimizing treatment of DNA methyltransferase inhibitor RG108 on porcine fibroblasts for somatic cell nuclear transfer.
Topics: Animals; Blastocyst; Cellular Reprogramming; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fibroblasts; Histones; Nuclear Transfer Techniques; Phthalimides; Swine; Tryptophan | 2019 |
Epigenetic modulation of glycoprotein VI gene expression by DNA methylation.
Topics: Case-Control Studies; Cells, Cultured; Coronary Disease; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Megakaryocytes; Phthalimides; Platelet Membrane Glycoproteins; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Tryptophan | 2020 |
A tri-functional probe mediated exponential amplification strategy for highly sensitive detection of Dnmt1 and UDG activities at single-cell level.
Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA Probes; DNA, Single-Stranded; Enzyme Assays; Humans; Limit of Detection; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Phthalimides; Single-Cell Analysis; Tryptophan; Uracil-DNA Glycosidase | 2020 |
Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.
Topics: Animals; Apoptosis; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Cellular Senescence; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression Regulation; Mesenchymal Stem Cells; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phthalimides; Real-Time Polymerase Chain Reaction; Swine; Tryptophan | 2020 |
Development of a kind of RG108-Fluorescein conjugates for detection of DNA methyltransferase 1 (DNMT1) in living cells.
Topics: DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Female; Fluorescein; Fluorescent Dyes; HeLa Cells; Humans; Molecular Docking Simulation; Phthalimides; Protein Binding; Protein Processing, Post-Translational; Tryptophan; Uterine Cervical Neoplasms | 2020 |
DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors.
Topics: Animals; Chronic Disease; DNA Methyltransferase 3A; Exploratory Behavior; Locomotion; Male; Mice; Phthalimides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Psychological; Synapses; Tryptophan | 2021 |
Learning against the Background of DNA Methyltransferase Inhibition Leads to the Formation of Memory That Is Resistant to Reactivation and Impairment.
Topics: Animals; Dizocilpine Maleate; Memory; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2021 |
The DNA methylation inhibitor RG108 protects against noise-induced hearing loss.
Topics: Animals; Auditory Threshold; DNA Methylation; Hearing Loss, Noise-Induced; Mice; Phthalimides; Quality of Life; Tryptophan | 2021 |
DNMT1 Inhibitor Restores RUNX2 Expression and Mineralization in Periodontal Ligament Cells.
Topics: Calcification, Physiologic; Cell Nucleus; Core Binding Factor Alpha 1 Subunit; DNA (Cytosine-5-)-Methyltransferase 1; Down-Regulation; Enzyme Inhibitors; Humans; Osteogenesis; Periodontal Ligament; Phthalimides; Tryptophan; Up-Regulation; Young Adult | 2021 |
HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes.
Topics: Azacitidine; Azepines; DNA Methylation; Epigenesis, Genetic; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Phthalimides; Quinazolines; Tryptophan | 2021 |
Neuroprotective effects of some epigenetic modifying drugs' on Chlamydia pneumoniae-induced neuroinflammation: A novel model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Chlamydophila Infections; Chlamydophila pneumoniae; Epigenesis, Genetic; Humans; Hydroxamic Acids; Inflammation; Neuroprotective Agents; Peptide Fragments; Phthalimides; THP-1 Cells; Tryptophan | 2021 |