tryptophan has been researched along with piperidines in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (32.76) | 18.7374 |
| 1990's | 10 (17.24) | 18.2507 |
| 2000's | 14 (24.14) | 29.6817 |
| 2010's | 12 (20.69) | 24.3611 |
| 2020's | 3 (5.17) | 2.80 |
| Authors | Studies |
|---|---|
| Lassen, JB; Squires, RF | 1 |
| Baran, L; Maj, J; Palider, W | 1 |
| Badawy, AA; Morgan, CJ | 1 |
| Bech, P; Bjerrum, H; Butler, B; Bøjholm, S; Folker, H; Gram, LF; Larsen, JK; Lauritzen, L; Loldrup, D; Møller, SE | 1 |
| Azorin, JM; Bovier, P; Jeanningros, R; Tissot, R; Widmer, J | 1 |
| Ashkenazi, R; Youdim, MB | 1 |
| Baumann, PA; Bischoff, S; Bittiger, H; Hauser, K; Maître, L; Paioni, R; Waldmeier, PC | 1 |
| Bethea, CL; Richardson, KD; Urban, JH; Van de Kar, LD | 1 |
| Magnussen, I | 1 |
| Cowen, PJ; Idzikowski, C; Mills, FJ; Nutt, D | 1 |
| Richardson, KD; Urban, JH; Van de Kar, LD | 1 |
| Engel, J; Lundborg, P | 1 |
| McConnell, HM; Morrisett, JD; Wien, RW | 1 |
| Misharin, AY; Polyanovsky, OL; Shaduri, MI; Timofeev, VP; Volkenstein, MV | 1 |
| Andén, NE; Corrodi, H; Fuxe, K | 1 |
| Denda, A; Ito, N; Kani, T; Matayoshi, K; Matsumura, K | 1 |
| Leonard, BE; Tonge, SR | 1 |
| Baumann, PA; Waldmeier, PC | 1 |
| Algeri, S; Ceci, A; Garattini, S; Gobbi, M; Liu, GQ; Murai, S | 1 |
| Grahame-Smith, DG; Green, AR; Hammond, M; O'Shaughnessy, K; Schächter, M | 1 |
| Cascieri, MA; Fong, TM; Hardwicke, S; Lewis, RT; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Sadowski, S; Shepheard, S | 1 |
| Breier, A | 1 |
| Maggio, R; Nanavati, S; Vogel, Z; Wess, J | 1 |
| Amano, Y; Fukami, T; Fukuroda, T; Ihara, M; Ishikawa, K; Kanda, F; Kojima, H; Niiyama, K; Ozaki, S; Yamakawa, T; Yano, M | 1 |
| Artigas, F; Bel, N; Casanovas, JM; Romero, L | 1 |
| Boks, GJ; Kroon, J; Tollenaere, JP | 1 |
| Bonn, G; Fiechtner, B; Glossmann, H; Huck, CW; Moebius, FF; Soellner, KE | 1 |
| Daenens, P; Tytgat, J; Ulens, C; Van Boven, M | 1 |
| Joshi, P; Kirschbaum, KS; Muthalagi, M; Parihar, HS; Schulte, MK; Venkatachalan, SP; Venkataraman, P | 1 |
| Bredesen, DE; Castro-Obregón, S; Chen, SF; Del Rio, G; Frankowski, H; Nicholls, DG; Rao, RV; Stoka, V; Swanson, RA; Vesce, S | 1 |
| El-Mahmoudy, A; Khalifa, M; Matsuyama, H; Shimizu, Y; Takewaki, T | 1 |
| ARIENS, EJ; HURKMANS, JA; van der SCHOOT, J; van ROSSUM, J | 1 |
| LEETE, E | 1 |
| Fujii, Y; Hossen, MA; Kamei, C; Kayasuga, R; Sugimoto, Y | 1 |
| Bender, D; Cumming, P; Marthi, MK; Olsen, AK; Smith, DF | 1 |
| Boudaka, A; Kobayashi, H; Neuhuber, WL; Shiina, T; Shimizu, Y; Takewaki, T; Wörl, J | 1 |
| Forouhar, F; Khan, JA; Tao, X; Tong, L | 1 |
| Coveñas, R; González-Moles, MA; Montero, I; Muñoz, M; Robles, MJ; Rosso, M | 1 |
| Aguilar, FJ; Esteban, F; González-Moles, MA; Muñoz, M; Redondo, M; Rosso, M | 1 |
| Fedorov, A; Hemminga, MA; Hesselink, RW; Prieto, M | 1 |
| Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH | 1 |
| Kanojia, M; Seedher, N | 1 |
| Hayes, D; Lee, LY; Lin, RL | 1 |
| Chen, YL; Huang, TT; Lai, MD; Lin, CC; Lin, CM; Weng, TY; Wu, CL; Yang, HJ; Yen, MC | 1 |
| Coveñas, R; González-Ortega, A; Muñoz, M | 1 |
| Hayashi, H; Nishimoto, S; Oh-ishi, T; Onaga, T; Shimoda, T | 1 |
| Charlip, A; Chu, T; Gallinetti, J; Mejia, P; Mitchell, JR; Peng, W; Robertson, L; Vose, S | 1 |
| Thornton, E; Vink, R | 1 |
| Hayashi, H; Oh-ishi, T; Onaga, T; Shimoda, T | 1 |
| Carranza, A; Coveñas, R; González-Ortega, A; Muñoz, M; Robles-Frias, MJ; Rosso, M; Salinas-Martín, MV | 1 |
| Brański, P; Pałucha-Poniewiera, A; Pilc, A; Stachowicz, K; Sławińska, A; Wierońska, JM | 1 |
| Almendro, V; Carranza, A; Coveñas, R; Garcia-Recio, S; González-Ortega, A; Muñoz, M; Salinas-Martín, MV | 1 |
| Hsu, CC; Lee, LY; Tapia, RJ | 1 |
| Ben Haj Salah, K; Buckinx, A; Cottone, E; De Bundel, D; Fehrentz, JA; Kooijman, R; Pierre, A; Smolders, I; Van Den Herrewegen, Y | 1 |
| Antoniadi, G; Eleftheriadis, T; Golfinopoulos, S; Liakopoulos, V; Nikolaou, E; Pissas, G; Stefanidis, I | 1 |
| Bhatti, R; Kaur, J; Kaur, S; Kumari, P; Singh, P | 1 |
| Bidlingmaier, M; Delahaut, P; Fichant, E; Görgens, C; Lange, T; Schilbach, K; Thevis, M; Thomas, A | 1 |
| Chen, L; Cui, L; Li, G; Liu, D; Qiu, J; Song, X; Sun, Y; Wang, C; Wang, J | 1 |
3 review(s) available for tryptophan and piperidines
| Article | Year |
|---|---|
Serotonin, schizophrenia and antipsychotic drug action.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Humans; Isoxazoles; Piperazines; Piperidines; Risperidone; Schizophrenia; Serotonin; Tryptophan | 1995 |
BIOSYNTHESIS OF ALKALOIDS.
Topics: Alkaloids; Enzymes; Metabolism; Niacin; Nicotinic Acids; Piperidines; Pyridines; Research; Tryptophan | 1965 |
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Cyclic ADP-Ribose; DNA Damage; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Mice; NAD; Neoplasms; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sirtuins; Tryptophan | 2007 |
1 trial(s) available for tryptophan and piperidines
| Article | Year |
|---|---|
Plasma ratio tryptophan/neutral amino acids in relation to clinical response to paroxetine and clomipramine in patients with major depression.
Topics: Adult; Aged; Amino Acids; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Paroxetine; Piperidines; Serotonin Antagonists; Tryptophan | 1990 |
54 other study(ies) available for tryptophan and piperidines
| Article | Year |
|---|---|
Potentiation of nialamide-induced hypermotility in mice by lithium and the 5-HT uptake inhibitors chlorimipramine and FG 4963.
Topics: Animals; Anisoles; Clomipramine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Female; Fenclonine; Lithium; Mice; Mice, Inbred Strains; Motor Activity; Nialamide; Piperidines; Serotonin; Stimulation, Chemical; Time Factors; Tryptophan | 1976 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State; Fenfluramine; Hindlimb; Lysergic Acid Diethylamide; Male; Metergoline; Muscle Contraction; p-Chloroamphetamine; Piperidines; Rats; Reflex; Serotonin; Tryptophan | 1976 |
Effects of acute paroxetine administration on tryptophan metabolism and disposition in the rat.
Topics: Administration, Oral; Animals; Antidepressive Agents; Brain; Corticosterone; Enzyme Induction; Hydrocortisone; In Vitro Techniques; Liver; Male; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1991 |
L-tyrosine and L-tryptophan membrane transport in erythrocytes and antidepressant drug choice.
Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Erythrocyte Membrane; Female; Fluvoxamine; Humans; Imipramine; Male; Mianserin; Middle Aged; Monoamine Oxidase Inhibitors; Oximes; Piperidines; Receptors, Adrenergic; Receptors, Serotonin; Tryptophan; Tyrosine | 1990 |
Serotonergic involvement in pharmacological action of the anxiolytic-sedatives thalidomide and supidimide.
Topics: Animals; Anti-Anxiety Agents; Brain; Catecholamines; Clorgyline; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Methoxydimethyltryptamines; Monoamine Oxidase; Motor Activity; p-Chloroamphetamine; Piperidines; Platelet Aggregation; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Thalidomide; Tranylcypromine; Tryptophan | 1985 |
Ifoxetine, a compound with atypical effects on serotonin uptake.
Topics: Animals; Blood Platelets; Brain Chemistry; Corpus Striatum; Haloperidol; In Vitro Techniques; Myocardium; Nalidixic Acid; Naphthyridines; Neurotransmitter Agents; Norepinephrine; Piperidines; Rats; Serotonin; Synaptosomes; Tryptophan; Tyramine; Tyrosine | 1986 |
Pharmacological studies on the serotoninergic and nonserotonin-mediated stimulation of prolactin and corticosterone secretion by fenfluramine. Effects of pretreatment with fluoxetine, indalpine, PCPA, and L-tryptophan.
Topics: Animals; Antidepressive Agents; Corticosterone; Fenclonine; Fenfluramine; Fluoxetine; Kinetics; Male; Piperidines; Prolactin; Propylamines; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1985 |
p,p'-DDT-induced myoclonus in mice: the effect of enhanced 5-HT neurotransmission.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; DDT; Female; Mice; Mice, Inbred Strains; Myoclonus; Paroxetine; Piperidines; Serotonin; Synaptic Transmission; Tryptophan | 1985 |
The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to L-tryptophan.
Topics: Adult; Binding, Competitive; Growth Hormone; Humans; Lysergic Acid Diethylamide; Male; Neurosecretory Systems; Piperidines; Prolactin; Radioimmunoassay; Ritanserin; Sleep; Sleep Stages; Tryptophan | 1987 |
Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats.
Topics: Animals; Blood Pressure; Desipramine; Dose-Response Relationship, Drug; Fenclonine; Fenfluramine; Fluoxetine; Heart Rate; Male; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Renin; Serotonin; Serotonin Antagonists; Time Factors; Tryptophan | 1985 |
Regional changes in monoamine levels and in the rate of tyrosine and tryptophan hydroxylation in 4 week old offspring of nursing mothers treated with the neuroleptic drug penfluridol.
Topics: 5-Hydroxytryptophan; Age Factors; Animals; Animals, Newborn; Biogenic Amines; Body Weight; Brain; Brain Chemistry; Brain Stem; Breast Feeding; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Female; Hydrocarbons, Halogenated; Hydroxylation; Limbic System; Neurons; Norepinephrine; Organ Size; Piperidines; Pregnancy; Rats; Serotonin; Toluene; Tranquilizing Agents; Tryptophan; Tyrosine | 1974 |
Spin-label-induced nuclear relaxation. Distances between bound saccharides, histidine-15, and tryptophan-123 on lysozyme in solution.
Topics: Acetamides; Acetates; Binding Sites; Chemical Phenomena; Chemistry; Cyclic N-Oxides; Deuterium; Electron Spin Resonance Spectroscopy; Glucosamine; Histidine; Magnetic Resonance Spectroscopy; Mathematics; Models, Chemical; Models, Structural; Muramidase; Oligosaccharides; Piperidines; Protein Conformation; Tryptophan | 1972 |
Conformational changes of aspartate aminotransferases in the region of Cys-45 residue observed by means of spin label.
Topics: Alkylation; Amino Acid Sequence; Animals; Aspartate Aminotransferases; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Cyclic N-Oxides; Cysteine; Cytosol; Electron Spin Resonance Spectroscopy; Iodoacetates; Maleates; Myocardium; Peptides; Piperidines; Protein Binding; Protein Conformation; Spin Labels; Swine; Tryptophan | 1973 |
The effect of psychotomimetic glycolate esters on central monoamine neurons.
Topics: Acetamides; Animals; Benzilates; Brain; Brain Chemistry; Catechols; Corpus Striatum; Cyclopentanes; Depression, Chemical; Dopamine; Fluorescence; Hallucinogens; Hypothalamus; Male; Mandelic Acids; Methyltyrosines; Mixed Function Oxygenases; Neurons; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Sensory Receptor Cells; Tryptophan; Tyrosine 3-Monooxygenase | 1972 |
Effect of various carcinogenic and non-carcinogenic substances on development of bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosoamine.
Topics: Acetamides; Acetanilides; Animals; Butanols; Carcinogens; Carcinoma, Papillary; Drug Synergism; Hyperplasia; Male; Morpholines; Neoplasms, Experimental; Nitrosamines; Piperidines; Rats; Succinimides; Thiocyanates; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms | 1974 |
The effect of some hallucinogenic drugs on the amino acid precursors of brain monoamines.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Cyclopentanes; Hallucinogens; Lysergic Acid Diethylamide; Mandelic Acids; Mescaline; Phencyclidine; Piperidines; Rats; Tryptophan; Tyrosine | 1970 |
Effects of CGP 11305 A, a new reversible and selective inhibitor of MAO A, on biogenic amine levels and metabolism in the rat brain.
Topics: Animals; Biogenic Amines; Brain; Brain Chemistry; Clorgyline; Dopamine; Female; Hydroxyindoleacetic Acid; In Vitro Techniques; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; Piperidines; Rats; Serotonin; Tryptophan | 1983 |
Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative.
Topics: Animals; Anticonvulsants; Brain; Corpus Striatum; Hydroxyindoleacetic Acid; Kinetics; Limbic System; Male; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1984 |
Inhibition of 5-hydroxytryptamine-mediated behaviour by the putative 5-HT2 antagonist pirenperone.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Haloperidol; Male; Methamphetamine; Motor Activity; Piperidines; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Tranylcypromine; Tryptophan | 1983 |
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Topics: Amines; Amino Acid Sequence; Animals; Binding Sites; Biphenyl Compounds; Cardiovascular System; CHO Cells; Cricetinae; Esters; Extravasation of Diagnostic and Therapeutic Materials; Female; Ferrets; Guinea Pigs; Heterocyclic Compounds; Humans; Hypnotics and Sedatives; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Solubility; Structure-Activity Relationship; Substance P; Tryptophan | 1995 |
Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Carbachol; Cell Line; Codon; GTP-Binding Proteins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Parasympatholytics; Piperidines; Proline; Protein Conformation; Rats; Receptors, Muscarinic; Recombinant Proteins; Restriction Mapping; RNA; Scopolamine Derivatives; Transfection; Tryptophan | 1993 |
Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity.
Topics: Animals; Drug Design; Endothelin Receptor Antagonists; Humans; Molecular Structure; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Structure-Activity Relationship; Substrate Specificity; Swine; Tryptophan; Vasodilator Agents | 1996 |
Adaptative changes of the serotonergic system after antidepressant treatments.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Clomipramine; Clorgyline; Fluvoxamine; Frontal Lobe; Hydroxyindoleacetic Acid; Imipramine; Microdialysis; Monoamine Oxidase Inhibitors; Piperidines; Pyrimidines; Raphe Nuclei; Rats; Serotonin; Stereotaxic Techniques; Tranylcypromine; Tryptophan | 1996 |
Possible ligand-receptor interactions for NK1 antagonists as observed in their crystal structures.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Isoquinolines; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Conformation; Pyridines; Quinuclidines; Software; Tryptophan | 1997 |
Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol delta 8-delta 7 isomerization.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Asparagine; Carrier Proteins; Cell Membrane; Glutamic Acid; Histidine; Humans; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Peptide Fragments; Piperidines; Saccharomyces cerevisiae; Steroid Isomerases; Threonine; Tryptophan | 1999 |
Interaction of p-fluorofentanyl on cloned human opioid receptors and exploration of the role of Trp-318 and His-319 in mu-opioid receptor selectivity.
Topics: Animals; Cloning, Molecular; Designer Drugs; Fentanyl; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Histidine; Humans; Ligands; Morphine; Mutation; Narcotics; Oocytes; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil; Tryptophan; Xenopus laevis | 2000 |
Functional group interactions of a 5-HT3R antagonist.
Topics: Animals; Arginine; Benzimidazoles; Benzyl Compounds; Cell Line; Humans; Kidney; Mice; Mutagenesis, Site-Directed; Nitrogen; Patch-Clamp Techniques; Piperazine; Piperazines; Piperidines; Protein Binding; Protein Interaction Mapping; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Tryptophan; Tyrosine | 2002 |
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death.
Topics: Animals; Annexin A5; Apoptosis; Caspase Inhibitors; Caspases; Cell Size; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fetus; Humans; Immunohistochemistry; Kidney; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Prosencephalon; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tryptophan | 2002 |
Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan | 2003 |
Phenylisopropylamine derivatives, structure and action.
Topics: Amphetamine; Chlorpromazine; Dibucaine; Diethylpropion; Dihydroxyphenylalanine; Dopamine; Ephedrine; Epinephrine; Hydrazines; Imipramine; Iproniazid; Mephentermine; Methamphetamine; Methylphenidate; Movement; Nialamide; Phenelzine; Phenethylamines; Phenmetrazine; Phenylhydrazines; Piperidines; Reserpine; Tranylcypromine; Tryptophan; Tyramine | 1962 |
Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice.
Topics: Animals; Capillary Permeability; Chlorpheniramine; Diphenhydramine; Evans Blue; Female; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Injections, Intradermal; Injections, Intravenous; Isothiuronium; Mast Cells; Mice; Mice, Mutant Strains; Piperidines; Receptors, Histamine H3; Skin; Thiourea; Tryptophan | 2003 |
PET evaluation of the uptake of N-[11C]methyl CP-643,051, an NK1 receptor antagonist, in the living porcine brain.
Topics: Animals; Brain; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Female; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Neurokinin-1 Receptor Antagonists; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Swine; Tryptophan | 2004 |
Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.
Topics: Alkaloids; Anilides; Animals; Benzodioxoles; Capsaicin; Cinnamates; Cricetinae; Enzyme Inhibitors; Esophagus; Female; Male; Mesocricetus; Mice; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Tachykinin; Species Specificity; TRPV Cation Channels; Tryptophan; Vagus Nerve | 2007 |
Neurokinin-1 receptors located in human retinoblastoma cell lines: antitumor action of its antagonist, L-732,138.
Topics: Apoptosis; Blotting, Western; Cell Count; Cell Proliferation; Child, Preschool; Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Retinal Neoplasms; Retinoblastoma; Stereoisomerism; Substance P; Tryptophan; Tumor Cells, Cultured | 2007 |
NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Laryngeal Neoplasms; Mitosis; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan | 2008 |
Membrane-bound peptides from V-ATPase subunit a do not interact with an indole-type inhibitor.
Topics: Acrylamide; Amino Acid Sequence; Amino Acids; Arginine; Fluorescence Resonance Energy Transfer; Indoles; Lipid Bilayers; Lipids; Membrane Proteins; Molecular Sequence Data; Peptides; Phosphatidylcholines; Phosphatidylglycerols; Piperidines; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Spectrometry, Fluorescence; Spectrophotometry; Tryptophan; Vacuolar Proton-Translocating ATPases | 2008 |
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan | 2008 |
Reversible binding of antidiabetic drugs, repaglinide and gliclazide, with human serum albumin.
Topics: Anilino Naphthalenesulfonates; Binding Sites; Carbamates; Fluorescent Dyes; Gliclazide; Humans; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Models, Biological; Piperidines; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Thermodynamics; Tryptophan | 2008 |
Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents.
Topics: Airway Resistance; Animals; Atropine; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Disease Models, Animal; Drug Combinations; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Hot Temperature; Humidity; Hyperthermia, Induced; Hyperventilation; Male; Neurons, Afferent; Piperidines; Receptors, Tachykinin; Specific Pathogen-Free Organisms; TRPV Cation Channels; Tryptophan | 2009 |
A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity.
Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Drug Therapy, Combination; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Mice, Inbred NOD; Neoplasms, Experimental; Nicotinamide Phosphoribosyltransferase; Piperidines; Tryptophan; Urinary Bladder Neoplasms | 2010 |
The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines.
Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Substance P; Tryptophan | 2012 |
Role of tachykinin and neurokinin receptors in the regulation of ovine omasal contractions.
Topics: Animals; Atropine; Electric Stimulation; Gene Expression; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Omasum; Organ Specificity; Piperidines; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sheep; Tachykinins; Tryptophan | 2012 |
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
Topics: Animals; Dietary Proteins; Humans; Kidney; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Piperidines; Proline; Protein Deficiency; Protein Serine-Threonine Kinases; Quinazolinones; Reperfusion Injury; Stress, Physiological; Tryptophan | 2012 |
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cells; Dopaminergic Neurons; Inflammation; Male; Motor Activity; Neurokinin-1 Receptor Antagonists; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Substance P; Substantia Nigra; Tryptophan | 2012 |
Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.
Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan | 2013 |
The substance P/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists.
Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tryptophan; Tumor Cells, Cultured | 2012 |
The antidepressant-like action of mGlu5 receptor antagonist, MTEP, in the tail suspension test in mice is serotonin dependent.
Topics: Animals; Antidepressive Agents; Citalopram; Diet; Excitatory Amino Acid Antagonists; Fenclonine; Fluoxetine; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Receptors, Kainic Acid; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Thiazoles; Tryptophan | 2014 |
The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer.
Topics: Antineoplastic Agents; Aprepitant; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MCF-7 Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan | 2014 |
Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats.
Topics: Airway Resistance; Analysis of Variance; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Evans Blue; Formoterol Fumarate; Hot Temperature; Male; Ovalbumin; Piperidines; Rats; Respiratory Hypersensitivity; Trachea; Tryptophan | 2015 |
Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling Model.
Topics: Animals; Benzazepines; beta-Arrestins; Brain; Dopamine Agonists; Glycine; Indoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Piperidines; Quinazolinones; Receptors, Ghrelin; Triazoles; Tryptophan | 2019 |
Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition.
Topics: Cells, Cultured; Dialysis Solutions; Epithelial Cells; Epithelial-Mesenchymal Transition; Glucose; Humans; Peritoneal Dialysis; Peritoneum; Piperidines; Primary Cell Culture; Protein Serine-Threonine Kinases; Quinazolinones; Reactive Oxygen Species; Tryptophan | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Formaldehyde; Humans; Hyperalgesia; Inflammation; Molecular Docking Simulation; Molecular Structure; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazines; Tryptophan | 2020 |
Comprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes.
Topics: Animals; Biomarkers; Chromatography, Liquid; Dipeptides; Doping in Sports; Female; Ghrelin; Humans; Indoles; Limit of Detection; Male; Piperidines; Pyrazoles; Rats; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2021 |
Application and prospect of quasi-targeted metabolomics in age-related hearing loss.
Topics: Acetylcholine; Amino Acids; Animals; Arginine; Chromatography, High Pressure Liquid; Coenzyme A; gamma-Aminobutyric Acid; Histamine; Methionine; Mice; Mice, Inbred C57BL; Piperidines; Presbycusis; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |