tryptophan has been researched along with nadp in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (50.00) | 18.7374 |
| 1990's | 24 (17.39) | 18.2507 |
| 2000's | 25 (18.12) | 29.6817 |
| 2010's | 15 (10.87) | 24.3611 |
| 2020's | 5 (3.62) | 2.80 |
| Authors | Studies |
|---|---|
| Badawy, AA; Evans, M | 2 |
| Obrebska, M; Wrońska-Nofer, T | 1 |
| Brochon, JC; Iwatsubo, M; Jallon, JM; Wahl, PH | 1 |
| Dalziel, K; Macfarlane, N; Mathews, B | 1 |
| Bertino, JR; Greenfield, NJ; Gupta, SV; Makulu, DR; Moroson, BA; Poe, M; Williams, MN | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Griffiths, DV; Kimber, BJ; King, RW; Roberts, GC; Scudder, P | 1 |
| Badawy, AA | 2 |
| Brochon, JC; Iwatsubo, M; Jallon, JM; Wahl, P | 1 |
| Verjee, ZH | 1 |
| Matthews, DA | 1 |
| Shibata, Y | 1 |
| Badawy, AA; Evans, M; Punjani, NF | 1 |
| Williams, MN | 1 |
| Berry, A; Deonarain, MP; Perham, RN; Scrutton, NS | 1 |
| Rao, CM; Zigler, JS | 1 |
| Amino, N; Asari, S; Fushimi, R; Hayashi, S; Kimura, S; Miyai, K; Yamaguchi, Y | 1 |
| Bender, DA | 2 |
| Brown, KA; Farnum, MF; Howell, EE; Kraut, J; Warren, MS | 1 |
| Appleman, JR; Beard, WA; Blakley, RL; Delcamp, TJ; Freisheim, JH; Huang, SM | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K | 1 |
| Davis, DJ | 1 |
| Fu, CS; Jacob, RA; McKee, RW; Swendseid, ME | 1 |
| Aoki, N; Inoue, K; Sanada, H; Wada, O | 1 |
| Bender, DA; Olufunwa, R | 1 |
| Birdsall, B; Feeney, J; Hammond, SJ; Roberts, GC; Searle, MS | 1 |
| Bulger, WH; Kupfer, D; Nanni, FJ | 1 |
| Kanoh, T; Mizoguchi, I; Suzuki, T | 1 |
| Armenian, AG; Gasparian, VK; Mardanian, SS | 1 |
| Mardanian, SS; Sarkisova, EG | 1 |
| Frydman, B; Frydman, RB; Tomaro, ML | 2 |
| Orrenius, S; Schenkman, JB; von Bahr, C; Wilson, BJ | 1 |
| Holmgren, A | 1 |
| Nath, MC; Shastri, NV | 1 |
| Dunlap, RB; Liu, JK | 1 |
| Grimm, U; Knapp, A; Schmitz, KW; Schmitz, W; Schulz, M; Smetan, M | 1 |
| Oguri, S | 1 |
| Kaseda, H; Kido, R; Ora, H | 1 |
| Berry, LJ | 1 |
| Maayan, ML; Rosenberg, IN | 1 |
| Sawyer, B; Slater, TF; Sträuli, U | 1 |
| Haljasmaa, O; Ross, SB | 1 |
| Cho-Chung, YS; Pitot, HC | 1 |
| DeMoss, RD; Jean, M | 1 |
| Kindl, H | 1 |
| Ceauşi, G; Dumitrescu, C | 1 |
| Gholson, RK | 1 |
| Greengard, P; Kalinsky, H; Manning, TJ; Zak, SB | 1 |
| Kulberg, AY; Schanin, SS; Tarkchanova, IA | 1 |
| Freisheim, JH; Huennekens, FM | 1 |
| Masana, Y; Nakagawa, I; Suzuki, T; Takahashi, T | 1 |
| Anderson, JA; Hsu, JC | 1 |
| Sourkes, TL | 1 |
| D'Souza, L; Freisheim, JH | 1 |
| Powanda, MC; Wannemacher, RW | 1 |
| Jansson, I; Orrenius, S; Ramstad, E; Wilson, BJ | 1 |
| Teuscher, G | 1 |
| Friedrich, B; Schlegel, HG | 1 |
| Friedman, PA; Kappelman, AH; Kaufman, S | 1 |
| Cross, DG; Fisher, HF; McGregor, LL | 1 |
| Brody, S | 1 |
| Ohguri, S | 1 |
| Sano, K; Shin, M; Umezawa, C | 2 |
| Bender, DA; Magboul, BI | 1 |
| Bender, DA; Totoe, L | 1 |
| Rao, BS; Satyanarayana, U | 1 |
| Babu, P; Siddiqui, SS | 1 |
| Marquardt, RR; Park, IK | 1 |
| Blakley, RL; Cocco, L; Groff, JP; London, RE | 1 |
| Delcamp, TJ; Freisheim, JH; Li, H; Meiering, EM; Wagner, G | 1 |
| Bohren, KM; Ehrig, T; Gabbay, KH; Prendergast, FG | 1 |
| Chatterjee, IB; Mukhopadhyay, CK | 1 |
| Frieden, C; Hoeltzli, SD | 2 |
| Baker, DH; Oduho, GW | 1 |
| Rao, MB; Rawat, UB | 1 |
| Li, B; Lin, SX | 1 |
| Jez, JM; Penning, TM; Schlegel, BP | 1 |
| Chekulayev, V; Chekulayeva, L; Kahru, A; Shevchuk, I | 1 |
| Vekshin, NL | 1 |
| Ma, H; Penning, TM; Ratnam, K | 1 |
| Adak, S; Crane, BR; Crooks, C; Getzoff, ED; Stuehr, DJ; Tainer, JA; Wang, Q | 1 |
| Cotton, NP; Jackson, JB; Peake, SJ; Venning, JD | 1 |
| Bradrick, TD; Howell, EE; Seo, HS; West, FW | 1 |
| Daff, S; Sagami, I; Sato, Y; Shimizu, T | 1 |
| Iwakura, M; Maki, K; Nakamura, T; Yamane, C | 1 |
| Feyereisen, R; Murataliev, MB | 1 |
| Doehr, O; Gutierrez, A; Paine, M; Roberts, GC; Scrutton, NS; Wolf, CR | 1 |
| Jackson, JB; Quirk, PG; Rodrigues, DJ; Venning, JD | 1 |
| Hubbard, PA; Kasper, CB; Kim, JJ; Paschke, R; Shen, AL | 1 |
| Fukuwatari, T; Shibata, K; Sugimoto, E | 1 |
| Fukuwatari, T; Fushiki, T; Ishihara, K; Shibata, K; Sugimoto, E | 1 |
| Casaus, JL; De la Rosa, MA; Gómez-Moreno, C; Hervás, M; Lostao, A; Medina, M; Navarro, JA; Sancho, J | 1 |
| Fukuwatari, T; Shibata, K; Sugimoto, E; Suzuki, Y | 1 |
| Fukuwatari, T; Morikawa, Y; Shibata, K; Sugimoto, E | 1 |
| Broos, J; Gabellieri, E; Jackson, JB; Strambini, GB; van Boxel, GI | 1 |
| NEMETH, AM | 1 |
| HJELT, L; LAHIKAINEN, T; OHMAN, S; VISAKORPI, JK | 1 |
| BROWN, FC | 1 |
| Harper, AE; Savage, JR | 1 |
| HATANAKA, M; HAYAISHI, O; KUNO, S; KURIHARA, N; NAKAJIMA, M; TANIUCHI, H | 1 |
| GREENGARD, P; QUINN, GP; REID, MB | 1 |
| Fukuwatari, T; Sasaki, R; Shibata, K; Wada, H | 1 |
| Dick, RA; Kensler, TW | 1 |
| Munro, AW; Neeli, R; Roitel, O; Scrutton, NS | 1 |
| Barbier, GG; Campbell, WH; Fischer, K; Hecht, HJ; Mendel, RR; Schwarz, G | 1 |
| Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Finazzi, G; Hippler, M; Sommer, F | 1 |
| Fukuwatari, T; Kimtjra, N; Ohta, M; Sasaki, R; Shibata, K | 1 |
| van der Donk, WA; Woodyer, R; Zhao, H | 1 |
| Denev, ID; Minkov, IN; Sundqvist, C; Yahubyan, GT | 1 |
| Ellis, EM; Lapthorn, AJ; Zhu, X | 1 |
| Bhakuni, V; Singh, K | 1 |
| Fukuwatari, T; Okuno, A; Shibata, K; Takahashi, K | 1 |
| Lee, AL; Mauldin, RV | 1 |
| Breicha, K; Hummel, W; Niefind, K; Richter, N | 1 |
| Gustafsson, FS; Meints, CE; Scrutton, NS; Wolthers, KR | 1 |
| Bhattacharyya, S; Das, AK; Dutta, D | 1 |
| Kawagoe, Y; Makino, Y; Oshita, S; Oto, N; Sugiyama, J; Yoshimura, M | 1 |
| Meints, CE; Simtchouk, S; Wolthers, KR | 1 |
| Badieyan, S; Ellerbrock, J; Han, A; Robinson, RM; Sobrado, P | 1 |
| Doi, K; Mutaguchi, Y; Ogura, R; Ohshima, T; Wakamatsu, T | 1 |
| Chandra, S; Doharey, PK; Saxena, JK; Siddiqi, MI; Suthar, MK; Verma, A | 1 |
| Louder, A; Meints, CE; Mothersole, RG; Wolthers, KR | 1 |
| Essen, LO; Geisselbrecht, Y; Ignatz, E; Kiontke, S | 1 |
| Banerjee, D; Immanuel, SRC; Raghunathan, A; Rajankar, MP | 1 |
| Gadhave, K; Giri, R; Kalita, P; Shukla, H; Tripathi, T | 1 |
| Cao, R; Periasamy, A; Rehman Alam, S; Siller, K; Wallrabe, H | 1 |
| Ding, Y; Zuo, R | 1 |
| Arnold, JM; Bader, DA; Cao, Q; Coarfa, C; Devarakonda, V; Donepudi, SR; Dubrulle, J; Jain, AK; Karanam, B; Kavuri, SM; Lotan, Y; Ma, J; Maity, S; McGuire, SE; Putluri, N; Putluri, V; Rajapakshe, K; Sikora, AG; Sreekumar, A; Stossi, F; Vantaku, V; Villanueva, H; von Rundstedt, FC | 1 |
| Anderson, JF; Dahmani, M; Neelakanta, G; Sultana, H | 1 |
| Fabara, AN; Fraaije, MW | 1 |
| Aleksandrov, A; Seo, D; Vos, MH; Zhuang, B | 1 |
| Chailyan, SG; Danielyan, KE; Ginosyan, SV; Grabski, HV; Tiratsuyan, SG | 1 |
4 review(s) available for tryptophan and nadp
| Article | Year |
|---|---|
The functions and regulation of tryptophan pyrrolase.
Topics: Allosteric Regulation; Aminolevulinic Acid; Animals; Dactinomycin; Feedback; Gluconeogenesis; Heme; Kinetics; Kynurenine; Liver; NAD; NADP; Rats; Tryptophan; Tryptophan Oxygenase | 1977 |
On the significance of drug-induced spectral changes in liver microsomes.
Topics: Alkaloids; Amphetamine; Aniline Compounds; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Desipramine; Hexobarbital; Hydroxylation; Microsomes, Liver; NADP; Nortriptyline; Oxidoreductases; Phenacetin; Rats; Spectrum Analysis; Testosterone; Tryptophan | 1972 |
[Physiopathology of the nutritional imbalance caused by deficiency of vitamin PP].
Topics: Amino Acids; Animals; Avitaminosis; Humans; NAD; NADP; Niacinamide; Pellagra; Tryptophan | 1968 |
Tryptophan and niacin nutrition--is there a problem?
Topics: Adult; Animals; Cognition Disorders; Environmental Exposure; Humans; Hydrolases; Iron Deficiencies; Kynurenine 3-Monooxygenase; Lead Poisoning; Liver; Mixed Function Oxygenases; NAD; NADP; Neoplasms; Niacin; Nutritional Requirements; Oxidative Stress; Trace Elements; Tryptophan; Zinc | 1996 |
134 other study(ies) available for tryptophan and nadp
| Article | Year |
|---|---|
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.
Topics: Animals; Cycloheximide; Dactinomycin; Ethanol; Humans; Hydrocortisone; Liver; Male; Morphine; NADP; Nicotinyl Alcohol; Phenobarbital; Premedication; Pyridines; Rats; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1975 |
Studies on the rate of incorporation of tryptophan into nicotinamide-adenine dinucleotides in rats chronically exposed to carbon disulphide.
Topics: Animals; Carbon Disulfide; Kinetics; Liver; NAD; NADP; Rats; Tryptophan | 1976 |
Pulse fluorimetry study of beef liver glutamate dehydrogenase reduced nicotinamide adenine dinucleotide phosphate complexes.
Topics: Animals; Binding Sites; Cattle; Glutamate Dehydrogenase; Guanosine Triphosphate; Liver; Macromolecular Substances; NADP; Protein Binding; Spectrometry, Fluorescence; Tryptophan | 1976 |
The purification and properties of NADP-dependent isocitrate dehydrogenase from ox-heart mitochondria.
Topics: Amino Acids; Animals; Cattle; Isocitrate Dehydrogenase; Kinetics; Mitochondria, Muscle; Molecular Weight; Myocardium; NADP; Spectrometry, Fluorescence; Tryptophan | 1977 |
Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.
Topics: Animals; Chromatography, Affinity; Circular Dichroism; Drug Resistance; Leukemia L1210; Methotrexate; Molecular Weight; NADP; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Tryptophan | 1977 |
19 Fnuclear magnetic resonance studies of ligand binding to 3-fluorotyrosine-and 6-fluorotryptophan-containing dihydrofolate reductase from Lactobacillus casei.
Topics: Binding Sites; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; NADP; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tryptophan; Tyrosine | 1977 |
Pulse fluorimetry study of energy transfers between tryptophan residues and NADPH in beef liver glutamate dehydrogenase complexes.
Topics: Chemical Phenomena; Chemistry; Energy Transfer; Fluorometry; Glutamate Dehydrogenase; In Vitro Techniques; Liver; Mathematics; NADP; Tryptophan | 1977 |
Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency.
Topics: 11-Hydroxycorticosteroids; Animals; Erythrocytes; Haplorhini; Kynurenine; Male; NAD; NADP; Papio; Riboflavin Deficiency; Tryptophan; Vitamin B 6 Deficiency | 1975 |
Interpretation of nuclear magnetic resonance spectra for Lactobacillus casei dihydrofolate reductase based on the X-ray structure of the enzyme-methotrexate-NADPH complex.
Topics: Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tryptophan; X-Ray Diffraction | 1979 |
On the regulation of tryptophan metabolism "via" kynurenine.
Topics: Animals; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenine; Mixed Function Oxygenases; NAD; NADP; Nicotinic Acids; ortho-Aminobenzoates; Phenylalanine; Rats; Serotonin; Solubility; Tryptophan; Xanthurenates | 1978 |
Prevention by pyrazole of the effects of chronic ethanol administration on the redox states of the hepatic nicotinamide--adenine dinucleotide (phosphate) couples and on liver and brain tryptophan metabolism in the rat.
Topics: Animals; Brain; Ethanol; Liver; Male; NAD; NADP; Oxidation-Reduction; Pyrazoles; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1979 |
Effect of N-bromosuccinimide modification on dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli. Activity, spectrophotometric, fluorescence and circular dichroism studies.
Topics: Amino Acids; Binding Sites; Circular Dichroism; Drug Resistance, Microbial; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methotrexate; NADP; Oxidation-Reduction; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides; Sulfhydryl Compounds; Tetrahydrofolate Dehydrogenase; Tryptophan | 1975 |
Cooperativity induced by a single mutation at the subunit interface of a dimeric enzyme: glutathione reductase.
Topics: Base Sequence; Binding Sites; Escherichia coli; Genes, Bacterial; Glutathione; Glutathione Reductase; Glycine; Kinetics; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; NADP; Plasmids; Protein Multimerization; Tryptophan | 1992 |
Levels of reduced pyridine nucleotides and lens photodamage.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Lens, Crystalline; NAD; NADP; Oxidation-Reduction; Rabbits; Rana catesbeiana; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Tryptophan; Ultraviolet Rays; Xenopus | 1992 |
New enzymatic method with tryptophanase for determining potassium in serum.
Topics: Ammonia; Escherichia coli; Glutamate Dehydrogenase; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ketoglutaric Acids; NADP; Potassium; Pyridoxal Phosphate; Tryptophan; Tryptophanase | 1992 |
Inhibition of tryptophan----niacin metabolism by dietary leucine and by leucine and 2-oxo-isocaproate in vitro.
Topics: Animals; Cells, Cultured; Depression, Chemical; Dietary Proteins; Keto Acids; Kynurenine; Leucine; Liver; NADP; Niacin; Niacinamide; Pellagra; Rats; Tryptophan; Xanthurenates | 1991 |
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Topics: Coenzymes; Deuterium; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tryptophan | 1991 |
Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis.
Topics: Allosteric Regulation; Apoenzymes; Binding Sites; Humans; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Ligands; Mutation; NADP; Phenylalanine; Protein Denaturation; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tryptophan | 1991 |
Neurotoxicity of tryptophan metabolites.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Kynurenic Acid; Male; NADP; Nervous System Diseases; Neurons; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1990 |
Tryptophan fluorescence studies of ferredoxin:NADP reductase indicate the presence of tryptophan in or near the ferredoxin binding site.
Topics: Binding Sites; Ferredoxin-NADP Reductase; Ferredoxins; Kinetics; NADH, NADPH Oxidoreductases; NADP; Plants; Spectrometry, Fluorescence; Tryptophan | 1990 |
Biochemical markers for assessment of niacin status in young men: levels of erythrocyte niacin coenzymes and plasma tryptophan.
Topics: Adult; Biomarkers; Diet; Erythrocytes; Food, Fortified; Humans; Leucine; Male; NAD; NADP; Niacin; Nutritional Status; Tryptophan | 1989 |
Effects of dietary pyrazinamide, tryptophan, or nicotinic acid and gamma-ray irradiation on levels of NAD and NADP in various organs of mice.
Topics: Animals; Eating; Female; Gamma Rays; Mice; Mice, Inbred C3H; NAD; NADP; Niacin; Organ Specificity; Pyrazinamide; Thymus Gland; Tryptophan | 1989 |
Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; In Vitro Techniques; Liver; Male; NAD; NADP; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan | 1988 |
Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes.
Topics: Amino Acid Sequence; Histidine; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Models, Molecular; NADP; Phenylalanine; Protein Conformation; Protons; Tetrahydrofolate Dehydrogenase; Tryptophan; Tyrosine | 1986 |
Characteristics of the active oxygen in covalent binding of the pesticide methoxychlor to hepatic microsomal proteins.
Topics: Benzoates; Benzoic Acid; beta Carotene; Butanols; Carotenoids; Catalase; Deferoxamine; Edetic Acid; Ethanol; Histidine; Hydrogen Peroxide; Mannitol; Methoxychlor; Microsomes, Liver; NADP; Oxygen; Pentetic Acid; Proteins; Salicylates; Superoxide Dismutase; Superoxides; tert-Butyl Alcohol; Tryptophan; Zinc | 1986 |
Increased urinary excretion of tryptophan metabolites in rats exposed to nitrogen dioxide.
Topics: Animals; Body Weight; Kynurenic Acid; Liver; Male; NAD; NADP; Nitrogen Dioxide; Pyridoxal Phosphate; Rats; Rats, Inbred F344; Tryptophan; Xanthurenates | 1988 |
[Localization of tryptophan residues in NADPH-adrenodoxin reductase with respect to the NADPH-binding center].
Topics: Adrenal Cortex; Animals; Binding Sites; Bromosuccinimide; Ferredoxin-NADP Reductase; Mitochondria; NADH, NADPH Oxidoreductases; NADP; Spectrometry, Fluorescence; Tryptophan | 1987 |
[The role of tryptophan residues of NADPH-adrenodoxin reductase in the formation of complex with adrenodoxin].
Topics: Adrenal Cortex; Adrenodoxin; Animals; Bromosuccinimide; Catalysis; Cattle; Electron Transport; Ferredoxin-NADP Reductase; Kinetics; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Tryptophan | 1987 |
Pyrrolooxygenases: isolation, properties, and products formed.
Topics: Ammonium Sulfate; Animals; Arylformamidase; Chemical Phenomena; Chemical Precipitation; Chemistry; Chloroplasts; Chromatography, DEAE-Cellulose; Chromatography, Gel; Drug Stability; Hot Temperature; Indoles; Light; Liver; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Oxygen; Plants; Radiation Effects; Rats; Skatole; Structure-Activity Relationship; Sulfites; Tryptophan | 1972 |
Effects of oxidation of tryptophan residues in thioredoxin from Escherichia coli by N-bromosuccinimide.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Bacterial Proteins; Chemical Phenomena; Chemistry; Chromatography, Gel; Cross Reactions; Electron Transport; Escherichia coli; Immunodiffusion; Indoles; NADP; Oxidation-Reduction; Oxidoreductases; Precipitin Tests; Pyrrolidinones; Rabbits; Ribonucleotides; Spectrometry, Fluorescence; Structure-Activity Relationship; Succinimides; Tryptophan | 1973 |
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.
Topics: Animals; Depression, Chemical; Ethanol; Humans; Hydrocortisone; Injections, Intraperitoneal; Kynurenine; Liver; NAD; NADP; Phenobarbital; Rats; Sodium Chloride; Sodium Salicylate; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
Effect of acetoacetate on liver and blood pyridine nucleotides in rats.
Topics: Acetoacetates; Administration, Oral; Animals; Deficiency Diseases; Depression, Chemical; Liver; Male; NAD; NADP; Nicotinic Acids; Rats; Tryptophan | 1973 |
Implication of a tryptophyl residue in the active site of dihydrofolate reductase.
Topics: Amino Acids; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Dialysis; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Lacticaseibacillus casei; Methotrexate; NADP; Oxidation-Reduction; Protein Denaturation; Spectrophotometry, Ultraviolet; Succinimides; Tetrahydrofolate Dehydrogenase; Tryptophan; Urea | 1974 |
[Studies on tryptophan metabolism in oligophrenic children. 2. Vitamin-dependent enzyme patterns (B1, B2, B6) and excretion of the tryptophan metabolites kynurenin, xanthurenic acid, trigonellinamide, and N-methylpyridone].
Topics: Child; Female; Humans; Hydrolases; Intellectual Disability; Kynurenine; Liver; Male; NADP; Pyridoxine; Riboflavin; Thiamine; Tryptophan; Xanthurenates | 1974 |
The relation between urinary excretion of tryptophan and niacin metabolites and pyridine nucleotides in the liver in rats fed a tryptophan-deficient diet.
Topics: Adenine Nucleotides; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Deficiency Diseases; Female; Liver; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Organ Size; Pyridones; Rats; Tryptophan | 1974 |
Enzymic demethylation of a carcinogenic tryptophan metabolite, 8-methoxykynurenic acid.
Topics: Animals; Carcinogens; Kidney; Kinetics; Kynurenic Acid; Liver; NAD; NADP; Organ Specificity; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Rats; Tryptophan | 1974 |
Effect of endotoxin on metabolic regulation in mice.
Topics: Animals; Carbon Radioisotopes; Cortisone; Cyproheptadine; Drug Antagonism; Endotoxins; Energy Metabolism; Enzyme Induction; Injections, Intraperitoneal; Injections, Intravenous; Kynurenine; Lethal Dose 50; Leucine; Liver; Mice; NAD; NADP; Orotic Acid; Protein Biosynthesis; RNA; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase | 1973 |
Pyridine nucleotides in the thyroid gland. II. Effect of nicotinamide, nicotinic acid and L-tryptophan administration.
Topics: Animals; Kinetics; Male; NAD; NADP; Niacin; Niacinamide; Oxidation-Reduction; Rats; Thyroid Gland; Tryptophan | 1968 |
An assay procedure for nicotinamide-adenine dinucleotides in rat liver and other tissues.
Topics: Alcohol Oxidoreductases; Animals; Buffers; Chemistry Techniques, Analytical; Edetic Acid; Ethanol; Glucosephosphate Dehydrogenase; In Vitro Techniques; Indicators and Reagents; Liver; NAD; NADP; Niacinamide; Phenazines; Phenols; Phosphates; Rats; Spectrophotometry; Subcellular Fractions; Tryptophan | 1964 |
Inhibition of liver phenylalanine and tryptophan hydroxylating enzyme systems in vitro and in vivo.
Topics: Aminopterin; Animals; Brain Chemistry; Coumarins; Enzyme Induction; Enzymes; Flavonoids; In Vitro Techniques; Liver; Liver Extracts; Methyldopa; Mice; Mixed Function Oxygenases; NAD; NADP; Phenylacetates; Phenylalanine; Rats; Serotonin; Tryptophan | 1966 |
Feedback control of rat liver tryptophan pyrrolase. I. End product inhibition of trytophan pyrrolase activity.
Topics: Animals; Buffers; Chromatography; Electrophoresis; Enzymes; Hot Temperature; Kinetics; Liver; Molecular Weight; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Oxidoreductases; Rats; Tryptophan; Ultracentrifugation | 1967 |
Indolelactate dehydrogenase from Clostridium sporogenes.
Topics: Clostridium; Indoles; Kinetics; L-Lactate Dehydrogenase; NAD; NADP; Tryptophan | 1968 |
[Oxidases and oxygenases in higher plants, I. On the occurrence of indolyl-(3)-acetaldehyde oxime and its formation from L-tryptophan].
Topics: Acetaldehyde; Carbon Isotopes; NADP; Oxidoreductases; Oximes; Oxygenases; Plants; Tryptophan | 1968 |
Regulation of NAD biosynthesis via the pyridine nucleotide cycle.
Topics: Adenosine Triphosphate; Animals; Bacillus; Carbon Isotopes; Escherichia coli; Hypophysectomy; In Vitro Techniques; Liver; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Pyridines; Pyrophosphatases; Rats; Transferases; Tryptophan; Tryptophan Oxygenase | 1968 |
Prevention and remission by adrenocortical steriods of nicotinamide deficiency disease. II. A study of the mechanism.
Topics: Adrenal Cortex Hormones; Animals; Corticosterone; Deficiency Diseases; NAD; NADP; Niacinamide; Nucleotides; Pyridines; Rats; Tryptophan | 1968 |
The loss of antigen(or hapten)-binding activity of Fab fragments of antibodies after irradiation by monochromatic ultraviolet light at 289 nm.
Topics: Animals; Antibodies; Antigen-Antibody Reactions; Binding Sites; Dinitrophenols; Fluorometry; Immune Sera; NADP; Rabbits; Radiation Effects; Spectrum Analysis; Tryptophan; Ultraviolet Rays | 1969 |
Effect of N-bromosuccinimide on dihydrofolate reductase.
Topics: Animals; Benzoates; Binding Sites; Bromine; Chemical Phenomena; Chemistry; Chickens; Hydrogen-Ion Concentration; Imides; Liver; Mercury; Molecular Weight; NADP; Pyrrolidinones; Spectrophotometry; Succinates; Sulfhydryl Compounds; Tetrahydrofolate Dehydrogenase; Tryptophan | 1969 |
Effect in man of the addition of tryptophan oniacin to the diet on the excretion of their metabolites.
Topics: Creatinine; Diet; Female; Humans; Kynurenic Acid; NAD; NADP; Niacinamide; Nicotinic Acids; Nitrogen; Pyridones; Tryptophan; Urea; Xanthurenates | 1969 |
Agroclavine hydroxylase of Claviceps purpurea.
Topics: Aminopterin; Ascomycota; Carbon Isotopes; Chromatography, Thin Layer; Cyanides; Edetic Acid; Ergot Alkaloids; Hydrogen-Ion Concentration; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygenases; Spectrophotometry; Tritium; Tryptophan | 1971 |
Effects of amino acid derivatives and drugs on the metabolism of tryptophan.
Topics: Adrenal Glands; Adrenalectomy; Animals; Brain; Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Deficiency Diseases; Depression, Chemical; Hydrocortisone; Hydroxyindoleacetic Acid; Liver; Metabolism; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; NAD; NADP; Oxidation-Reduction; Protein Biosynthesis; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase; Yohimbine | 1971 |
Circular dichroic titration of dihydrofolate reductase with TPNH.
Topics: Chemical Phenomena; Chemistry; Circular Dichroism; NADP; Protein Binding; Streptococcus; Tetrahydrofolate Dehydrogenase; Tryptophan | 1971 |
Tryptophan availability as a control of hepatic pyridine nucleotide concentration in mice.
Topics: Adrenalectomy; Allopurinol; Animals; Depression, Chemical; Hydrocortisone; Kinetics; Liver; Male; Mice; NAD; NADP; Stimulation, Chemical; Tryptophan; Tryptophan Oxygenase | 1971 |
Conversion of agroclavine by mammalian cytochrome P-450.
Topics: Adrenal Glands; Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chromatography, Thin Layer; Cytochromes; Ergot Alkaloids; Guinea Pigs; Isotope Labeling; Male; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity; Spectrophotometry; Tryptophan | 1971 |
[Tryptophan metabolism of streptomycetes. 3. Tryptophan degradation in cell free extracts of Streptomyces cremeus].
Topics: Ammonium Sulfate; Coenzymes; Enzyme Induction; Methylene Blue; NAD; NADP; ortho-Aminobenzoates; Streptomyces; Toluidines; Tryptophan | 1971 |
[Hydroxylation of phenylalanine by Hydrogenomonas eutropha H 16].
Topics: Cell-Free System; Chromatography, Gel; Enzyme Induction; Mixed Function Oxygenases; NAD; NADP; Phenylalanine; Phenylalanine Hydroxylase; Phenylpyruvic Acids; Pseudomonas; Tryptophan; Tyrosine | 1972 |
Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.
Topics: Ammonium Sulfate; Animals; Brain; Calcium Phosphates; Carbon Isotopes; Catalase; Chromatography, Thin Layer; Colorimetry; Decarboxylation; Hydrogen Peroxide; Iron; Kinetics; Mixed Function Oxygenases; NADP; Oxidoreductases; Oxygen; Pteridines; Pterins; Rabbits; Spectrometry, Fluorescence; Spectrophotometry; Structure-Activity Relationship; Tryptophan | 1972 |
Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides.
Topics: Animals; Bromine; Chemical Phenomena; Chemistry; Chromatography, Paper; Chromatography, Thin Layer; Chymotrypsin; Indoles; Liver; Microsomes, Liver; Muramidase; NADP; Oxidation-Reduction; Oxidoreductases; Papain; Pepsin A; Peptides; Plants; Rats; Succinimides; Sulfites; Trypsin Inhibitors; Tryptophan | 1972 |
The binding of -ketoglutarate in a binary complex and in a ternary complex with NADP + by L-glutamate dehydrogenase.
Topics: Animals; Binding Sites; Catalysis; Cattle; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Glutamates; Ketoglutaric Acids; Kinetics; Liver; Mathematics; Molecular Weight; NADP; Niacinamide; Oxidation-Reduction; Protein Binding; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tryptophan | 1972 |
Regulation of pyridine nucleotide levels and ratios in Neurospora crassa.
Topics: Culture Media; Genetics, Microbial; Glucosephosphate Dehydrogenase; Kynurenine; Mixed Function Oxygenases; Mutation; NAD; NADP; Neurospora; Neurospora crassa; Nicotinic Acids; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Tryptophan | 1972 |
Effects of excess leucine on growth and tryptophan and niacin metabolism in rats.
Topics: Animals; Body Weight; Diet; Erythrocytes; Female; Hydroxyindoleacetic Acid; Isoleucine; Leucine; NAD; NADP; Nicotinic Acids; Organ Size; Pellagra; Quinolinic Acids; Rats; Time Factors; Tryptophan; Valine; Vitamin B 6 Deficiency | 1980 |
Effect of L-tryptophan and L-leucine on biosynthesis of niacin-related compounds in Saccharomyces carlsbergensis.
Topics: Culture Media; Leucine; NAD; NADP; Niacin; Niacinamide; Nicotinamidase; Pentosyltransferases; Saccharomyces; Tryptophan | 1982 |
The effects of a dietary excess of leucine on the synthesis of nicotinamide nucleotides in the rat.
Topics: Animals; Diet; Enzyme Activation; Hydrolases; Kynurenine; Leucine; Liver; Male; NADP; Niacin; Niacinamide; Pellagra; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1983 |
Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra.
Topics: Animals; Castration; Estrone; Female; Liver; NAD; NADP; Niacinamide; Pellagra; Rats; Rats, Inbred Strains; Tryptophan | 1984 |
In vivo conversion of tryptophan to nicotinic acid in rats studied by simultaneous incorporation of [3H]-tryptophan and [14C]-nicotinic acid into liver NAD and NADP.
Topics: Animals; Dietary Proteins; Liver; NAD; NADP; Niacin; Rats; Rats, Inbred Strains; Tryptophan; Weaning | 1983 |
Kynurenine hydroxylase mutants of the nematode Caenorhabditis elegans.
Topics: Animals; Caenorhabditis; Chromosome Mapping; Genetic Complementation Test; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Mutation; NAD; NADP; Tryptophan | 1980 |
Effects of niacin deficiency on pyridine nucleotide levels and enzyme activities in various organs of young growing quail.
Topics: Animals; Body Weight; Coturnix; Dose-Response Relationship, Drug; Liver; Muscles; NAD; NADP; Niacin; Nicotinic Acids; Quail; Tryptophan | 1982 |
Nuclear magnetic resonance study of interaction of ligands with streptococcus faecium dihydrofolate reductase labeled with [gamma-13C]tryptophan.
Topics: Adenosine Diphosphate Ribose; Carbon Isotopes; Folic Acid; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Pteroylpolyglutamic Acids; Pyrimidines; Spin Labels; Streptococcus; Tetrahydrofolate Dehydrogenase; Tryptophan | 1982 |
Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver.
Topics: Allopurinol; Animals; Corticosterone; Dactinomycin; Glucose; Liver; Male; NAD; NADP; Propranolol; Rats; Starvation; Stimulation, Chemical; Tryptophan; Tryptophan Oxygenase | 1981 |
Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.
Topics: Amino Acid Sequence; Glutamic Acid; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tryptophan; Water | 1995 |
Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
Topics: Aldehyde Reductase; Base Sequence; Binding Sites; Coenzymes; Isoquinolines; Molecular Sequence Data; Mutation; NADP; Oligodeoxyribonucleotides; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Tryptophan | 1994 |
NADPH-initiated cytochrome P450-mediated free metal ion-independent oxidative damage of microsomal proteins. Exclusive prevention by ascorbic acid.
Topics: Adenosine Diphosphate; Animals; Ascorbic Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Guinea Pigs; Hydrolysis; Iron; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Proteins; Tryptophan; Tyrosine | 1994 |
19F NMR spectroscopy of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase: equilibrium folding and ligand binding studies.
Topics: Base Sequence; Binding Sites; DNA Primers; Escherichia coli; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Protein Conformation; Protein Folding; Tetrahydrofolate Dehydrogenase; Tryptophan; Urea | 1994 |
Quantitative efficacy of niacin sources for chicks: nicotinic acid, nicotinamide, NAD and tryptophan.
Topics: Analysis of Variance; Animal Feed; Animals; Biological Assay; Chickens; Dose-Response Relationship, Drug; Eating; Liver; Male; Muscles; NAD; NADP; Niacin; Niacinamide; Regression Analysis; Tryptophan; Weight Gain | 1993 |
Purification, kinetic characterization and involvement of tryptophan residue at the NADPH binding site of xylose reductase from Neurospora crassa.
Topics: Aldehyde Reductase; Anilino Naphthalenesulfonates; Binding Sites; Bromosuccinimide; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Kinetics; Molecular Weight; NADP; Neurospora crassa; Protein Conformation; Spectrometry, Fluorescence; Tryptophan | 1996 |
Fluorescence-energy transfer in human estradiol 17 beta-dehydrogenase-NADPH complex and studies on the coenzyme binding,.
Topics: Binding Sites; Cold Temperature; Energy Transfer; Estradiol Dehydrogenases; Humans; In Vitro Techniques; Kinetics; Molecular Structure; NADP; Spectrometry, Fluorescence; Tryptophan | 1996 |
Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Animals; Enzyme Inhibitors; Fluorescence; Kinetics; Ligands; Liver; Mutagenesis, Site-Directed; NADP; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Substrate Specificity; Testosterone; Tryptophan | 1996 |
Refolding of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase in the presence of ligand: a stopped-flow NMR spectroscopy study.
Topics: Circular Dichroism; Escherichia coli; Fluorine; Folic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; NADP; Protein Folding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Tryptophan | 1998 |
Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid].
Topics: Animals; Female; Indazoles; Mice; Molecular Structure; NADP; Radiation-Sensitizing Agents; Tryptophan; Tumor Cells, Cultured; Ultraviolet Rays | 1997 |
Resonant energy transfer from proteins to pyridine nucleotides in mitochondria.
Topics: Animals; Energy Transfer; In Vitro Techniques; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Proteins; Rats; Spectrometry, Fluorescence; Tryptophan | 1998 |
The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Arginine; Binding Sites; Kinetics; Liver; Methionine; Mutagenesis, Site-Directed; NAD; NADP; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrometry, Fluorescence; Static Electricity; Time Factors; Tryptophan | 1999 |
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition.
Topics: Escherichia coli; Feedback; Hydrogen Peroxide; Kinetics; Models, Chemical; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Point Mutation; Structure-Activity Relationship; Tryptophan | 1999 |
Evidence for the stabilization of NADPH relative to NADP(+) on the dIII components of proton-translocating transhydrogenases from Homo sapiens and from Rhodospirillum rubrum by measurement of tryptophan fluorescence.
Topics: Animals; Binding Sites; Fluorescence; Hominidae; Humans; Kinetics; NAD; NADP; NADP Transhydrogenases; Oxidation-Reduction; Rhodospirillum rubrum; Tryptophan | 1999 |
Effects of peroxisome-proliferators on the TRP-NAD pathway.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Clofibrate; Female; Liver; Male; NAD; NADP; Niacin; Oxidation-Reduction; Pentosyltransferases; Peroxisome Proliferators; Peroxisomes; Phenothiazines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tryptophan | 1999 |
Effects of single-tryptophan mutations on R67 dihydrofolate reductase.
Topics: Binding Sites; Chromatography, Gel; Circular Dichroism; Energy Transfer; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; NADP; Phenylalanine; Protein Folding; Quantum Theory; R Factors; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Tryptophan | 2000 |
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan | 2000 |
Systematic circular permutation of an entire protein reveals essential folding elements.
Topics: Binding Sites; Circular Dichroism; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; NADP; Peptide Fragments; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Thermodynamics; Titrimetry; Tryptophan; Urea | 2000 |
Functional interactions in cytochrome P450BM3. Evidence that NADP(H) binding controls redox potentials of the flavin cofactors.
Topics: Animals; Bacterial Proteins; Binding, Competitive; Cytochrome P-450 Enzyme System; Electron Transport; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Flavoproteins; Mixed Function Oxygenases; Mutagenesis, Site-Directed; NAD; NADP; NADP Transhydrogenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phosphorus Radioisotopes; Protein Binding; Protein Structure, Tertiary; Protons; Rats; Spectrometry, Fluorescence; Tryptophan | 2000 |
Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases.
Topics: Alanine; Binding Sites; Catalysis; Cytochrome c Group; Enzyme Activation; Flavin-Adenine Dinucleotide; Histidine; Humans; Kinetics; Mutagenesis, Site-Directed; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Protein Structure, Tertiary; Recombinant Proteins; Solubility; Spectrometry, Fluorescence; Thermodynamics; Tryptophan | 2000 |
A change in ionization of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase regulates both hydride transfer and nucleotide release.
Topics: Amino Acid Substitution; Binding Sites; Catalysis; Fluorescence; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Mutation; NADP; NADP Transhydrogenases; Nucleotides; Protein Conformation; Protein Subunits; Protons; Rhodospirillum rubrum; Spectrometry, Fluorescence; Tryptophan | 2001 |
NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.
Topics: Amino Acid Substitution; Animals; Catalysis; Crystallography, X-Ray; Electron Transport; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Humans; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; NADP; NADPH-Ferrihemoprotein Reductase; Niacinamide; Protein Conformation; Rats; Recombinant Proteins; Serine; Spectrophotometry; Tryptophan | 2001 |
Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats.
Topics: Animals; Antitubercular Agents; Diet; Eating; Liver; Male; NAD; NADP; Niacin; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tryptophan; Weight Gain | 2001 |
Elevation of blood NAD level after moderate exercise in young women and mice.
Topics: Adult; Animals; Exercise; Female; Humans; Male; Mice; Mice, Inbred ICR; NAD; NADP; Physical Exertion; Tryptophan | 2001 |
Anabaena sp. PCC 7119 flavodoxin as electron carrier from photosystem I to ferredoxin-NADP+ reductase. Role of Trp(57) and Tyr(94).
Topics: Anabaena; Desulfovibrio vulgaris; Dose-Response Relationship, Drug; Electrons; Ferredoxin-NADP Reductase; Flavodoxin; Kinetics; Microscopy, Fluorescence; Models, Chemical; Mutation; NADP; Photosynthetic Reaction Center Complex Proteins; Protein Binding; Riboflavin; Spectrophotometry; Thermodynamics; Time Factors; Tryptophan; Tyrosine; Ultraviolet Rays | 2002 |
Elucidation of the toxic mechanism of the plasticizers, phthalic acid esters, putative endocrine disrupters: effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in rats.
Topics: Administration, Oral; Animals; Body Weight; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Energy Intake; Liver; NAD; NADP; Niacin; Organ Size; Rats; Tryptophan | 2002 |
Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.
Topics: Animals; Diet; Fats; Fatty Liver; Feeding Behavior; Liver; Male; NAD; NADP; Niacin; Organ Size; Orotic Acid; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Vitamin B Deficiency; Weight Gain | 2002 |
Tryptophan phosphorescence spectroscopy reveals that a domain in the NAD(H)-binding component (dI) of transhydrogenase from Rhodospirillum rubrum has an extremely rigid and conformationally homogeneous protein core.
Topics: Acrylamide; Dimerization; Escherichia coli; Glycerol; Kinetics; Luminescent Measurements; Models, Molecular; NAD; NADP; NADP Transhydrogenases; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protons; Rhodospirillum rubrum; Spectrometry, Fluorescence; Spectrophotometry; Temperature; Time Factors; Tryptophan | 2003 |
INITIATION OF ENZYME FORMATION BY BIRTH.
Topics: Animals; Animals, Newborn; Glucose-6-Phosphatase; Guinea Pigs; Liver; NADP; Research; Tryptophan | 1963 |
HARTNUP DISEASE IN TWO SIBLINGS. CLINICAL OBSERVATIONS AND BIOCHEMICAL STUDIES.
Topics: Adolescent; Ataxia; Child; Eczema; Genetics, Medical; Hartnup Disease; Humans; NAD; NADP; Niacin; Nicotinic Acids; Pellagra; Protein Deficiency; Renal Aminoacidurias; Siblings; Tryptophan | 1964 |
NICOTINAMIDE ADENINE DINUCLEOTIDE LEVELS IN RAT BRAIN.
Topics: Brain; Dietary Fats; Metabolism; NAD; NADP; Niacin; Niacinamide; Nicotinic Acids; Pharmacology; Protein Deficiency; Rats; Research; Reserpine; Tryptophan | 1964 |
INFLUENCE OF GELATIN ON GROWTH AND LIVER PYRIDINE NUCLEOTIDE CONCENTRATION OF THE RAT.
Topics: Amino Acids; Caseins; Diet; Gelatin; Glycine; Growth; Liver; NAD; NADP; Niacin; Nicotinic Acids; Nucleotides; Rats; Research; Tryptophan | 1964 |
ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID.
Topics: Benzene; Benzoates; Carbon Isotopes; Catechols; Glycols; Kynurenic Acid; Levulinic Acids; Metabolism; Mixed Function Oxygenases; NAD; NADP; ortho-Aminobenzoates; Oxidoreductases; Pseudomonas; Research; Salicylic Acid; Tryptophan | 1964 |
PITUITARY INFLUENCE OF PYRIDINE NUCLEOTIDE METABOLISM OF RAT LIVER.
Topics: Adrenal Glands; Brain Chemistry; Fluorometry; Hypophysectomy; Intestines; Kidney; Liver; Lung; Metabolism; Muscles; Myocardium; NAD; NADP; Niacin; Niacinamide; Pharmacology; Pituitary Gland; Rats; Research; Spectrophotometry; Spleen; Tryptophan | 1964 |
Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
Topics: Animals; Dose-Response Relationship, Drug; Eating; Liver; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Predictive Value of Tests; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Weaning; Weight Gain | 2004 |
The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Antioxidants; Carbon; Catalysis; Deuterium; Hydrogen; Hydrogen-Ion Concentration; Ketones; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; NADH, NADPH Oxidoreductases; NADP; Oxygen; Phylogeny; Progesterone; Protein Binding; Rats; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Stereoisomerism; Tryptophan; Zinc | 2004 |
Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes.
Topics: Alanine; Amino Acid Substitution; Animals; Bacillus megaterium; Bacterial Proteins; Cytochrome P-450 Enzyme System; Flavin-Adenine Dinucleotide; Histidine; Kinetics; Mixed Function Oxygenases; Mutation; NADP; NADPH-Ferrihemoprotein Reductase; Potentiometry; Protein Structure, Tertiary; Pyridines; Rats; Spectrophotometry; Substrate Specificity; Thermodynamics; Tryptophan | 2005 |
Structural basis of eukaryotic nitrate reduction: crystal structures of the nitrate reductase active site.
Topics: Animals; Arginine; Binding Sites; Body Water; Chickens; Crystallography, X-Ray; Electron Transport Chain Complex Proteins; Eukaryotic Cells; Models, Molecular; Molecular Sequence Data; Molybdenum; NADP; Nitrate Reductases; Nitrates; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Pichia; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Tryptophan | 2005 |
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan | 2005 |
Release of oxidized plastocyanin from photosystem I limits electron transfer between photosystem I and cytochrome b6f complex in vivo.
Topics: Animals; Binding Sites; Chlamydomonas; Cytochrome b6f Complex; Dose-Response Relationship, Drug; Electrons; Glutamic Acid; Glutamine; Kinetics; Mutation; NADP; Oxygen; Phenotype; Photosynthesis; Photosystem I Protein Complex; Plastocyanin; Protein Binding; Serine; Spectrophotometry; Time Factors; Tryptophan | 2005 |
Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes.
Topics: Adult; Diet; Female; Humans; Japan; Male; NAD; NADP; Niacin; Niacinamide; Nutrition Policy; Sex Characteristics; Tryptophan | 2004 |
Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration.
Topics: Deuterium; Escherichia coli Proteins; Kinetics; Mutation; NAD; NADH, NADPH Oxidoreductases; NADP; Protein Structure, Tertiary; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Structural Homology, Protein; Time Factors; Tryptophan; Xylitol | 2005 |
Organization of protochlorophyllide oxidoreductase in prolamellar bodies isolated from etiolated carotenoid-deficient wheat leaves as revealed by fluorescence probes.
Topics: Anilino Naphthalenesulfonates; Carotenoids; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Light; NADP; Oxidoreductases Acting on CH-CH Group Donors; Plant Leaves; Plastids; Protochlorophyllide; Spectrometry, Fluorescence; Spectrophotometry; Temperature; Time Factors; Triticum; Tryptophan | 2005 |
Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Animals; Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Hydrophobic and Hydrophilic Interactions; Hydroxybutyrate Dehydrogenase; Liver; Methionine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Substrate Specificity; Tartrates; Tryptophan | 2006 |
Toxoplasma gondii ferredoxin-NADP+ reductase: Role of ionic interactions in stabilization of native conformation and structural cooperativity.
Topics: Animals; Catalysis; Chromatography, Gel; Circular Dichroism; Enzyme Stability; Ferredoxin-NADP Reductase; Flavin-Adenine Dinucleotide; Guanidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Ions; Models, Biological; Models, Molecular; Molecular Weight; NADP; Protein Binding; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Static Electricity; Temperature; Toxoplasma; Tryptophan | 2008 |
Comparison of the nicotinamide catabolism among rat strains.
Topics: Animals; Body Weight; Eating; Male; NAD; NADP; Niacinamide; Rats; Rats, Inbred Strains; Solubility; Species Specificity; Tryptophan; Vitamins; Water | 2009 |
Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli Proteins; Methionine; Methotrexate; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 2010 |
The three-dimensional structure of AKR11B4, a glycerol dehydrogenase from Gluconobacter oxydans, reveals a tryptophan residue as an accelerator of reaction turnover.
Topics: Amino Acid Sequence; Amino Acid Substitution; Apraxia, Ideomotor; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Gluconobacter oxydans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Static Electricity; Structural Homology, Protein; Substrate Specificity; Sugar Alcohol Dehydrogenases; Tryptophan | 2010 |
Tryptophan 697 modulates hydride and interflavin electron transfer in human methionine synthase reductase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Biocatalysis; Electron Transport; Ferredoxin-NADP Reductase; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Flavoproteins; Humans; Hydrogen; Kinetics; Mutant Proteins; NAD; NADP; Oxidation-Reduction; Protein Binding; Recombinant Proteins; Sequence Alignment; Tryptophan | 2011 |
Crystal structure and fluorescence studies reveal the role of helical dimeric interface of staphylococcal FabG1 in positive cooperativity for NADPH.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; Alcohol Oxidoreductases; Bacterial Proteins; Cloning, Molecular; Crystallization; DNA, Bacterial; Escherichia coli; Fluorescence; NADP; Protein Binding; Protein Interaction Mapping; Protein Multimerization; Protein Structure, Secondary; Spectrometry, Fluorescence; Staphylococcus aureus; Tryptophan | 2012 |
Non-destructive evaluation of ATP content and plate count on pork meat surface by fluorescence spectroscopy.
Topics: Adenosine Triphosphate; Animals; Bacteria; Colony Count, Microbial; Food Microbiology; Food Storage; Least-Squares Analysis; Meat; NADP; Reproducibility of Results; Spectrometry, Fluorescence; Swine; Temperature; Tryptophan | 2013 |
Aromatic substitution of the FAD-shielding tryptophan reveals its differential role in regulating electron flux in methionine synthase reductase and cytochrome P450 reductase.
Topics: Amino Acid Substitution; Amino Acids, Aromatic; Catalysis; Cytochrome c Group; Dinitrocresols; Electron Transport; Escherichia coli; Ferredoxin-NADP Reductase; Flavin-Adenine Dinucleotide; Kinetics; Mutagenesis, Site-Directed; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Plasmids; Protein Structure, Tertiary; Recombinant Proteins; Thermodynamics; Titrimetry; Tryptophan | 2013 |
Tryptophan-47 in the active site of Methylophaga sp. strain SK1 flavin-monooxygenase is important for hydride transfer.
Topics: Amino Acid Sequence; Catalytic Domain; Flavin-Adenine Dinucleotide; Flavins; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Piscirickettsiaceae; Protein Stability; Sequence Alignment; Tryptophan | 2013 |
Biochemical characterization of an L-tryptophan dehydrogenase from the photoautotrophic cyanobacterium Nostoc punctiforme.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Bacterial Proteins; Enzyme Stability; Genes, Bacterial; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Molecular Weight; NAD; NADP; Nostoc; Phylogeny; Recombinant Proteins; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity; Temperature; Tryptophan | 2014 |
NADP⁺ binding effects tryptophan accessibility, folding and stability of recombinant B. malayi G6PD.
Topics: Animals; Brugia malayi; Glucosephosphate Dehydrogenase; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; NADP; Protein Binding; Protein Folding; Protein Stability; Protein Unfolding; Recombinant Proteins; Spectrum Analysis; Tryptophan | 2016 |
Role of active site loop in coenzyme binding and flavin reduction in cytochrome P450 reductase.
Topics: Alanine; Arabidopsis; Arginine; Aspartic Acid; Bacillus megaterium; Catalysis; Catalytic Domain; Chromatography, High Pressure Liquid; Cytochromes c; Flavins; Humans; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Mutation; NADP; NADPH-Ferrihemoprotein Reductase; Protein Binding; Protein Domains; Saccharomyces cerevisiae; Static Electricity; Tryptophan | 2016 |
Nicotinamide Adenine Dinucleotides Arrest Photoreduction of Class II DNA Photolyases in FADH
Topics: Archaeal Proteins; Deoxyribodipyrimidine Photo-Lyase; Electron Transport; Flavin-Adenine Dinucleotide; Kinetics; Light; Methanosarcina; Molecular Conformation; Mutation; NAD; NADP; Oxidation-Reduction; Tryptophan | 2018 |
Integrated constraints based analysis of an engineered violacein pathway in Escherichia coli.
Topics: Escherichia coli; Indoles; Metabolic Engineering; Models, Biological; NADP; Operon; Tryptophan | 2018 |
Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase.
Topics: Animals; Catalysis; Dithionitrobenzoic Acid; Fasciola; Flavin-Adenine Dinucleotide; Glutaredoxins; Helminth Proteins; Multienzyme Complexes; Mutation; NADH, NADPH Oxidoreductases; NADP; Protein Binding; Protein Conformation; Protein Domains; Protein Stability; Protein Unfolding; Thioredoxins; Tryptophan; Urea | 2018 |
Single-cell redox states analyzed by fluorescence lifetime metrics and tryptophan FRET interaction with NAD(P)H.
Topics: Cytosol; Doxorubicin; Energy Metabolism; Flavin-Adenine Dinucleotide; Fluorescence; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Microscopy, Fluorescence, Multiphoton; Mitochondria; NAD; NADP; Optical Imaging; Oxidation-Reduction; Oxidative Phosphorylation; Reactive Oxygen Species; Single-Cell Analysis; Tryptophan | 2019 |
Direct Aromatic Nitration System for Synthesis of Nitrotryptophans in Escherichia coli.
Topics: Arginine; Bacillus subtilis; Biocatalysis; Biosynthetic Pathways; Biotechnology; Escherichia coli; Fermentation; Indoles; Metabolic Engineering; NADP; Nitric Oxide; Nitric Oxide Synthase; Streptomyces; Tryptophan | 2019 |
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.
Topics: Aldehyde Oxidase; Animals; Cell Line, Tumor; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Kynurenine; Male; Metabolomics; Mice; NADP; Neoplasm Invasiveness; Neoplasm Staging; Nucleotides; Pentose Phosphate Pathway; RNA-Seq; Tissue Array Analysis; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2020 |
Rickettsial pathogen uses arthropod tryptophan pathway metabolites to evade reactive oxygen species in tick cells.
Topics: Anaplasma phagocytophilum; Animals; Hemin; Host-Pathogen Interactions; Hydrolases; Ixodes; Kynurenic Acid; Kynurenine; NADP; Reactive Oxygen Species; RNA Interference; Transaminases; Tryptophan; Tryptophan Oxygenase; Up-Regulation; Xanthurenates | 2020 |
Production of indigo through the use of a dual-function substrate and a bifunctional fusion enzyme.
Topics: Biotechnology; Escherichia coli; Indigo Carmine; NADP; Oxygenases; Tryptophan | 2020 |
Characterization of Light-Induced, Short-Lived Interacting Radicals in the Active Site of Flavoprotein Ferredoxin-NADP
Topics: Bacillus subtilis; Catalytic Domain; Electron Transport; Ferredoxin-NADP Reductase; Free Radicals; Light; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; NADP; Protein Binding; Quantum Theory; Tryptophan; Tyrosine | 2021 |
Experimental Clarification of PRPS-1 Structural Essentials.
Topics: Diphosphates; Histidine; Molecular Docking Simulation; NAD; NADP; Nucleotides; Phosphates; Phosphoribosyl Pyrophosphate; Purines; Pyridines; Pyrimidines; Ribose-Phosphate Pyrophosphokinase; Tryptophan | 2022 |