tryptophan has been researched along with methotrexate in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (38.89) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bertino, JR; Greenfield, NJ; Gupta, SV; Makulu, DR; Moroson, BA; Poe, M; Williams, MN | 1 |
| Matthews, DA | 1 |
| Williams, MN | 1 |
| Bitar, KG; Dunlap, RB; Ericsson, LH; Freisheim, JH; Reddy, AV | 1 |
| Capel, ID; Pinnock, MH; Williams, DC | 1 |
| Howells, DW; Hyland, K; Smith, I; Strobel, S | 1 |
| Gross, WL; Reinhold-Keller, E; Schnabel, A; Wolff, HH | 1 |
| Brown, KA; Farnum, MF; Howell, EE; Kraut, J; Warren, MS | 1 |
| McIvor, RS; Simonsen, CC | 1 |
| Dunlap, RB; Liu, JK | 1 |
| Little, JR; Rubenstein, WA | 1 |
| Krakoff, IH | 1 |
| Gal, EM; Marshall, FD; Morgan, M | 1 |
| Dayton, PG; Kinkade, JM; Vogler, WR | 1 |
| Lin, MS; Winchell, HS | 1 |
| Blakley, RL; Cocco, L; Groff, JP; London, RE | 1 |
| Delcamp, TJ; Freisheim, JH; Li, H; Meiering, EM; Wagner, G | 1 |
| Frieden, C; Hoeltzli, SD | 1 |
| Adams, J; Evenson, DA; McIvor, RS; Wagner, CR | 1 |
| Gerig, JT; Lau, EY | 1 |
| Dietrich, A; Ehrlich, W; Grätz, R; Kröger, H; Wild, A | 1 |
| Cole, SP; Deeley, RG; Ito, K; Oleschuk, CJ; Vasa, MZ; Westlake, C | 1 |
| Cole, SP; Deeley, RG; Oleschuk, CJ | 1 |
| CUTTS, JH | 1 |
| Darlington, LG; Forrest, CM; Kennedy, A; Stone, TW; Stoy, N | 1 |
| Lee, AL; Mauldin, RV | 1 |
| Alapa, MT; Goodey, NM; Hagmann, DF; Hall, SM; Korunow, SG; Kwon, KS; Mauro, AK | 1 |
| Kwon, I; Zheng, S | 1 |
| DuHadaway, JB; Gilmour, S; Mandik-Nayak, L; Muller, AJ; Pigott, E; Prendergast, GC | 1 |
| Gan, F; Meng, F; Ye, G | 1 |
36 other study(ies) available for tryptophan and methotrexate
| Article | Year |
|---|---|
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.
Topics: Animals; Chromatography, Affinity; Circular Dichroism; Drug Resistance; Leukemia L1210; Methotrexate; Molecular Weight; NADP; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Tryptophan | 1977 |
Interpretation of nuclear magnetic resonance spectra for Lactobacillus casei dihydrofolate reductase based on the X-ray structure of the enzyme-methotrexate-NADPH complex.
Topics: Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tryptophan; X-Ray Diffraction | 1979 |
Effect of N-bromosuccinimide modification on dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli. Activity, spectrophotometric, fluorescence and circular dichroism studies.
Topics: Amino Acids; Binding Sites; Circular Dichroism; Drug Resistance, Microbial; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methotrexate; NADP; Oxidation-Reduction; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides; Sulfhydryl Compounds; Tetrahydrofolate Dehydrogenase; Tryptophan | 1975 |
An active center tryptophan residue in dihydrofolate reductase: chemical modification, sequence surrounding the critical residue, and structural homology considerations.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Bromosuccinimide; Drug Resistance, Microbial; Lacticaseibacillus casei; Methotrexate; Tetrahydrofolate Dehydrogenase; Tryptophan | 1977 |
An in vitro assessment of the effect of cytotoxic drugs upon the intestinal absorption of nutrients in rats.
Topics: Animals; Ascorbic Acid; Biological Transport, Active; Fluorouracil; Glucose; Intestinal Absorption; Male; Methotrexate; Palmitic Acids; Rats; Tryptophan; Vitamin A | 1979 |
Tryptophan and serotonin metabolism in familial erythrophagocytic lymphohistiocytosis.
Topics: Aging; Amino Acids; Biopterins; Child, Preschool; Etoposide; Histiocytosis, Non-Langerhans-Cell; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Male; Methotrexate; Neopterin; Prednisolone; Serotonin; Tryptophan | 1992 |
[Tryptophan-induced fasciitis-scleroderma-eosinophilia syndrome].
Topics: Aged; Creatine Kinase; Diagnosis, Differential; Eosinophilia; Fasciitis; Female; Fructose-Bisphosphate Aldolase; Glucocorticoids; Humans; Hydroxychloroquine; Methotrexate; Middle Aged; Scleroderma, Systemic; Skin; Syndrome; Time Factors; Tryptophan | 1991 |
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
Topics: Coenzymes; Deuterium; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tryptophan | 1991 |
Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Line; Cloning, Molecular; Cricetinae; DNA; Drug Resistance; Gene Expression Regulation; Methotrexate; Mice; Molecular Sequence Data; Phenylalanine; Plasmids; Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Transfection; Tryptophan | 1990 |
Talking turkey.
Topics: Animals; Diet Therapy; Food Analysis; Humans; Methotrexate; Prednisone; Psoriasis; Remission, Spontaneous; Triamcinolone; Tryptophan; Turkeys | 1971 |
Implication of a tryptophyl residue in the active site of dihydrofolate reductase.
Topics: Amino Acids; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Dialysis; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Lacticaseibacillus casei; Methotrexate; NADP; Oxidation-Reduction; Protein Denaturation; Spectrophotometry, Ultraviolet; Succinimides; Tetrahydrofolate Dehydrogenase; Tryptophan; Urea | 1974 |
Properties of the active sites of antibodies specific for folic acid.
Topics: Animals; Antibodies; Binding Sites; Cattle; Cross Reactions; Depression, Chemical; Dialysis; Epitopes; Fluorescence; Fluorescent Antibody Technique; Folic Acid; gamma-Globulins; Glutamates; Haptens; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunization; Immunoelectrophoresis; Liver; Methotrexate; Oxidation-Reduction; Precipitin Tests; Pyrrolidinones; Rabbits; Serum Albumin; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium; Tryptophan; Ultraviolet Rays | 1970 |
Increase in uric acid biosynthesis produced by 2-substituted thiadiazoles.
Topics: Azaserine; Azoles; Diazooxonorleucine; Mercaptopurine; Methotrexate; Niacinamide; Nicotinic Acids; Tryptophan; Uric Acid | 1965 |
Studies on the metabolism of 5-hydroxytryptamine (serotonin). IV. The effect of various drugs on the in vivo hydroxylation of tryptophan by the brain tissue.
Topics: Animals; Birds; Brain; Chromatography; Hydrazines; In Vitro Techniques; Intestine, Small; Kidney; Liver; Methotrexate; Methyldopa; Mixed Function Oxygenases; Myocardium; Rats; Reserpine; Serotonin; Tryptophan | 1965 |
Plasma levels of methotrexate in cancer patients as studied by an improved spectrophotofluorometric method.
Topics: Adult; Aged; Chromatography, Ion Exchange; Creatinine; Cytarabine; Diatrizoate; Female; Folic Acid; Heparin; Humans; Hydrogen-Ion Concentration; Male; Methods; Methotrexate; Middle Aged; Neoplasms; Oxidation-Reduction; Potassium Permanganate; Spectrometry, Fluorescence; Time Factors; Triamterene; Tritium; Tryptophan; Tungsten | 1974 |
Kinetics of amino acid transport across bone marrow cell membranes.
Topics: Amino Acids; Animals; Biological Transport, Active; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Membrane; DNA; Dogs; Extracellular Space; Glucagon; Glutamates; Histidine; Imidazoles; Insulin; Kinetics; Methionine; Methotrexate; Models, Biological; Serine; Time Factors; Tryptophan | 1970 |
Nuclear magnetic resonance study of interaction of ligands with streptococcus faecium dihydrofolate reductase labeled with [gamma-13C]tryptophan.
Topics: Adenosine Diphosphate Ribose; Carbon Isotopes; Folic Acid; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Pteroylpolyglutamic Acids; Pyrimidines; Spin Labels; Streptococcus; Tetrahydrofolate Dehydrogenase; Tryptophan | 1982 |
Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.
Topics: Amino Acid Sequence; Glutamic Acid; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tryptophan; Water | 1995 |
19F NMR spectroscopy of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase: equilibrium folding and ligand binding studies.
Topics: Base Sequence; Binding Sites; DNA Primers; Escherichia coli; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Protein Conformation; Protein Folding; Tetrahydrofolate Dehydrogenase; Tryptophan; Urea | 1994 |
Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan.
Topics: Animals; Crystallography, X-Ray; Folic Acid Antagonists; Kinetics; Methotrexate; Mice; Mutagenesis, Site-Directed; Phenylalanine; Serine; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 1996 |
Effects of fluorine substitution on the structure and dynamics of complexes of dihydrofolate reductase (Escherichia coli).
Topics: Amides; Amino Acid Sequence; Binding Sites; Computer Simulation; Escherichia coli; Fluorine; Folic Acid; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Models, Chemical; Models, Structural; Protein Binding; Protein Conformation; Protein Structure, Secondary; Software; Tetrahydrofolate Dehydrogenase; Time Factors; Tryptophan | 1997 |
The effect of tryptophan plus methionine, 5-azacytidine, and methotrexate on adjuvant arthritis of rat.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Azacitidine; Body Weight; Drug Therapy, Combination; Freund's Adjuvant; Male; Methionine; Methotrexate; Rats; Tryptophan | 1999 |
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
Topics: Amino Acid Sequence; Base Sequence; Biological Transport; Cell Line; DNA Primers; Estradiol; Glucuronides; Humans; Leukotriene C4; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Sequence Homology, Amino Acid; Substrate Specificity; Sulfinpyrazone; Tryptophan | 2001 |
Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3.
Topics: Amino Acid Substitution; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Line; Estradiol; Genetic Vectors; Humans; Hydroxysteroid Dehydrogenases; Kidney; Leucovorin; Leukotriene C4; Membrane Glycoproteins; Membranes; Methotrexate; Mutagenesis, Site-Directed; Peptide Fragments; Substrate Specificity; Taurocholic Acid; Transfection; Tryptophan | 2003 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine | 1964 |
Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Etidronic Acid; Female; Humans; Kynurenine; Methotrexate; Neopterin; Osteoporosis; Prednisolone; Raloxifene Hydrochloride; Receptors, Glutamate; Tryptophan | 2003 |
Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli Proteins; Methionine; Methotrexate; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 2010 |
Development of a fluorescently labeled thermostable DHFR for studying conformational changes associated with inhibitor binding.
Topics: Enzyme Stability; Fluorescence; Fluorescent Dyes; Folic Acid Antagonists; Geobacillus stearothermophilus; Methotrexate; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tryptophan | 2011 |
Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Computer Simulation; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Naphthalenes; Phenylalanine; Protein Binding; Protein Engineering; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Tryptophan | 2013 |
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase | 2014 |
Bimetallic gold/silver nanoclusters as a fluorescent probe for detection of methotrexate and doxorubicin in serum.
Topics: Antineoplastic Agents; Doxorubicin; Fluorescent Dyes; Gold; Humans; Limit of Detection; Metal Nanoparticles; Methotrexate; Silver; Spectrometry, Fluorescence; Tryptophan | 2019 |