tryptophan has been researched along with kynurenine in 2264 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 624 (27.56) | 18.7374 |
| 1990's | 169 (7.46) | 18.2507 |
| 2000's | 276 (12.19) | 29.6817 |
| 2010's | 662 (29.24) | 24.3611 |
| 2020's | 533 (23.54) | 2.80 |
| Authors | Studies |
|---|---|
| Cherkasov, IA; Churakova, NI; Kravchenko, NA | 1 |
| Sakiyama, F | 1 |
| Badawy, AA | 8 |
| Verjee, ZH | 1 |
| Baker, HF; Cross, AJ; Crow, TJ; Glover, V; Joseph, MH; Killpack, WS; Lofthouse, R; Longden, A; Owen, F; Riley, GJ | 1 |
| Shibata, Y | 1 |
| Eto, T; Masuda, S; Mizuno, K; Sakiyama, F; Tsujita, T; Yamasaki, N | 1 |
| Birnbaum, D; Böttcher, F; König, A; Lutzmann, H; Samsonova, IA | 1 |
| Casida, JE; Engel, JL; Moscioni, AD | 1 |
| Sourkes, TL; St-Arnaud-McKenzie, D; Young, SN | 1 |
| Curtius, HC; Gitzelmann, R; Otten, A; Wegmann, H | 1 |
| Baker, HF; Crow, TJ; Jospeh, MH; Riley, GJ; Risby, D | 1 |
| Kamyshev, NG; Ponomarenko, VV; Smirnova, GP | 1 |
| Bühlen, E; Bühner, R; Byrd, DJ; Kochen, W | 1 |
| Forman, P; Justice, P; Tabahoff, B; Wong, PW | 1 |
| Kimmig, J; Kreysel, HW; Meyerhoff, K | 1 |
| Soda, K; Tanizawa, K; Yamamoto, T | 1 |
| Allegri, G; Costa, C; Crepaldi, G; De Antoni, A; Muggeo, M | 3 |
| Beisel, WR; Dinterman, RE; Powanda, MC; Wannemacher, RW | 1 |
| Grimm, U; Knapp, A; Reddemann, H; Schlenzka, K; Schmitz, KW; Schmitz, W; Schulz, M; Smetan, M | 2 |
| Brenner, A; Wapnir, RA | 1 |
| Annable, L; Chouinard, G; Sourkes, TL; Young, SN | 1 |
| Soda, K; Tanizawa, K | 1 |
| Gaertner, FH; Shetty, AS | 3 |
| Beaudoin, AR | 1 |
| Geuscher, G | 1 |
| Kiely, ME; Sourkes, TL | 1 |
| Gál, EM; Sherman, AD; Young, RB | 1 |
| Annable, L; Chouinard, Q; Sourkes, TL; Young, SN | 1 |
| Savvateeva, EV | 1 |
| Amdisen, A; Møller, SE | 1 |
| Guseĭnova, RS | 1 |
| Bossé, TR; Donald, EA | 1 |
| Muramatsu, S; Suzuki, M; Takahashi, T; Watanabe, M; Yoshida, M | 1 |
| Brown, RR; Wolf, H | 3 |
| Bousquet, B; Civatte, J; Dreux, C; Escande, C; Garnier, JP; Ramelet, AA; Sohier, J | 1 |
| Joseph, MH; Kadam, BV | 1 |
| Lau, S; Yong, S | 1 |
| Allegri, G; Baccichetti, F; Costa, C; De Antoni, A; Vanzan, S | 5 |
| Abdel-Tawab, GA; El-Kholy, ZA; El-Sewedy, SM; El-Zoghby, SM | 1 |
| Kirk, L; Møller, SE | 1 |
| Allegri, G; Costa, C; De Antoni, A | 1 |
| Abdel-Rafea, A; Abdel-Tawab, GA; El-Dardiri, N; El-Kabariti, H; El-Kholy, ZA; Mostafa, MH; Saad, AA | 1 |
| De Bruin, EJ; Hankes, LV; Jansen, CR; Schmaeler, M | 1 |
| Montenero, AS | 1 |
| Kuz'mina, LA; Lopatina, NG; Ponomarenko, VV | 1 |
| VON Riesen, VL | 1 |
| Fokkens, W; Haije, WG; Hop, WC; Peters, HA; Portengen, H; Teulings, FA; van der Werf-Messing, B | 1 |
| Bell, ED | 1 |
| Reddi, OS; Reddy, KR; Reddy, MV | 1 |
| Bloomfield, MR; Green, AR; Seed, M; Woods, HF | 1 |
| Joseph, MH | 1 |
| Fujiwara, M; Hayaishi, O; Hirata, F; Mizuno, N; Nukiwa, T; Shibata, M; Watanabe, Y | 1 |
| Davis, M; Labadarios, D; Rossouw, JE; Williams, R | 1 |
| Curtius, HC; Redweik, U; Wegmann, H | 1 |
| Gorbacheva, LN | 1 |
| Hall-Tipping, DL; Joseph, MH | 1 |
| Howells, AJ; Summers, KM | 2 |
| Hullin, RP | 1 |
| Bouknight, RR; Sadoff, HL | 2 |
| Howells, AJ; Ryall, RL | 1 |
| Lexa, D; Redpath, JL; Santus, R; Walrant, P | 1 |
| Arend, RA; Brown, RR; Huang, T; Kuntz, RE; Moore, JA | 1 |
| Fremming, KH; Kirk, L; Moller, SE | 1 |
| Brown, RR; Yeh, JK | 2 |
| De Bruin, E; Hankes, LV; Jansen, CR; Schmaeler, M; Vorster, L | 1 |
| Binazzi, M | 1 |
| Hankes, LV; Jansen, CR | 1 |
| Bender, DA; Humm, RP; Smith, WR | 1 |
| Matsushima, M | 1 |
| Knapp, A; Teichmann, E; Teichmann, W | 1 |
| Natsuki, R; Sakiyama, F | 1 |
| Brown, RR; Leklem, JE | 2 |
| Narita, K; Sakiyama, F; Tsujita, T; Yamasaki, N | 1 |
| Kurbanov, Kh | 1 |
| Churakova, NI; Kaverzneva, ED; Kravchenko, NA; Serebriakov, EP | 1 |
| Cholnoky, P; Horváth, K; Szabó, L | 1 |
| Clark, JA; Clark, MS; Palfreyman, ES; Palfreyman, MG | 1 |
| Abdel-Tawab, GA; el-Kabariti, HS; el-Zoghby, SM; Girgis, LH; Moursi, GE; Zeitoun, R | 1 |
| Arend, RA; Brown, RR; Leklem, JE; Linkswiler, H; Rose, DP | 1 |
| Brown, RR; Hankes, LV; Jansen, CR; Leklem, JE | 1 |
| Green, AR; Sourkes, TL; Young, SN | 1 |
| Ionascu, L; Ionescu, G; Romas, NA; Sholem, S; Veenema, RJ | 1 |
| Hankes, LV; Schmaeler, M | 1 |
| Joseph, MH; Risby, D | 1 |
| Barlow, GB; Wilkinson, AW | 2 |
| Costa, E; Foldes, A | 1 |
| Green, AR; Joseph, MH; Woods, HF | 2 |
| Korkhov, VV | 1 |
| Kuroda, M; Narita, K; Sakiyama, F | 1 |
| Grimm, U; Knapp, A; Machill, G; Reddemann, H; Schlenzka, K; Schmitz, KW; Schmitz, W; Schulz, M; Smetan, M | 1 |
| Badawy, AA; Evans, M | 3 |
| Bell, ED; Bulbrook, RD; Hayward, JL; Tong, D | 1 |
| Brown, RR; Nyholm, K; Wolf, H | 1 |
| Brown, RR | 1 |
| Coppini, D; Mauri, C; Plessi, M; Silingardi, V | 1 |
| Allegri, G; Costa, C; De Antoni, A; Rubaltelli, FF | 2 |
| Brown, RR; Leklem, JE; Linkswiler, HM; Rose, DP | 1 |
| Calandra, P | 3 |
| Binazzi, M; Calandra, P | 5 |
| Bührlen, E; Byrd, DJ; Kochen, W | 1 |
| Nishimoto, Y; Shibata, Y; Takeuchi, F; Tatsuma, Y | 1 |
| Azhar, S; Krishna Murti, CR; Srivastava, AK | 1 |
| Moon, RJ; Morris, KM | 3 |
| Budny, JA; Henderson, LM; Swan, PB; Triebwasser, KC | 1 |
| Pewnim, T; Seifert, J | 2 |
| Koppenol, WH; Maskos, Z; Rush, JD | 1 |
| Beal, MF; Bird, ED; Matson, WR; Milbury, P; Ogawa, T; Ryan, EA; Storey, E | 1 |
| Mori, A; Suzuki, S | 1 |
| Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM | 1 |
| Egawa, B; Horiguchi, K; Kaku, A; Yamada, K; Yamamoto, H | 1 |
| Heyes, MP; Markey, SP; Saito, K | 2 |
| Bermes, EW; Flanigan, RC; Holmes, EW; Kinzler, GJ; Reckard, CR; Russell, PM; Thompson, KD | 1 |
| Eguchi, K; Kamimura, S; Kudo, T; Mitsui, Y; Mizutani, Y; Yonezawa, M | 1 |
| Beal, MF; Bird, ED; Matson, WR; Milbury, P; Myers, RH; Ogawa, T; Saso, S | 1 |
| Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE | 1 |
| Wachter, H; Weiss, G; Werner, ER; Werner-Felmayer, G | 1 |
| Heyes, MP; Maize, JC; Quearry, B; Silver, RM; Sternberg, EM; Vionnet-Fuasset, M | 1 |
| Bonkovsky, HL; Gerron, GG; Healey, JF; Lourie, AN | 1 |
| Nagayama, F; Serrano, AE | 1 |
| Fathi, M; Mainetti, C; Saurat, JH | 1 |
| Beams, RM; Critchley, MA; Hodson, HF; Iyer, R; Knowles, RG; Madge, DJ; Pogson, CI; Salter, M | 1 |
| Borden, EC; Brown, RR; Datta, SP; Malone, DG; Ozaki, Y; Sondel, PM | 1 |
| Bender, DA; Njagi, EN | 2 |
| Demisch, L; Kaczmarczyk, P | 1 |
| Heyes, MP; Quearry, BJ | 1 |
| Milovanović, DD; Milovanović, L; Radulović, D; Stanković, B | 1 |
| Hashizume, T; Kinae, N; Kosaka, K; Ozawa, T; Santo, H; Tsujisawa, H; Yamashita, M | 1 |
| Hino, T; Nakagawa, M | 1 |
| Clarkson, NA; Duch, DS; Edelstein, MP; Knowles, RG; Pogson, CI; Salter, M | 1 |
| Kido, R; Okuno, E | 1 |
| Savvateeva, E | 1 |
| Peters, JC | 1 |
| Bender, DA; Danielian, PS; Njagi, EN | 1 |
| Habara-Ohkubo, A; Takikawa, O; Yoshida, R | 1 |
| Elderfield, A; Truscott, R | 1 |
| Baran, H; Schwarcz, R | 1 |
| Fujimoto, H; Haneda, M; Nakatsuka, M; Nisimoto, Y; Nomura, S; Ohta, T; Shibata, Y; Takeuchi, F; Tamai, T; Tsubouchi, R | 1 |
| Ishiguro, I; Nagamura, Y; Naito, J; Ogawa, H | 2 |
| Gromm, V; Martinsons, A; Rudzite, V | 1 |
| Dalmane, A; Liepina, D; Rudzite, V; Sileniece, G; Zirne, R | 1 |
| Abramson, FP; Bacher, JD; Boni, RL; Heyes, MP; Ji, XD; Markey, SP; Yergey, JA | 1 |
| Bender, DA | 2 |
| During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Matson, WR; Roth, RH; Swartz, KJ | 1 |
| Eguchi, K; Kamimura, S; Sekiba, K | 1 |
| Feng, GS; Taylor, MW | 1 |
| Dierich, MP; Fuchs, D; Möller, AA; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 1 |
| Sano, K; Shin, M; Umezawa, C | 2 |
| Gamache, PH; Godefroy, F; Matson, WR; Weil-Fugazza, J | 1 |
| Rajurkar, V; Shastri, NV | 1 |
| Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV | 1 |
| Beal, MF; Bird, ED; Gamache, PH; Matson, WR; Swartz, KJ | 1 |
| Fuchs, D; Möller, AA; Reibnegger, G; Stöckle, E; Wachter, H; Werner, ER | 1 |
| Beal, MF; During, MJ; Freese, A; Swartz, KJ | 1 |
| During, MJ; Freese, A; Martin, JB; Swartz, KJ | 1 |
| Connolly, SM; Griffing, WL; Quimby, SR; Winkelmann, RK | 1 |
| Adachi, N; Nishijima, M; Ogasawara, T | 1 |
| Chang, CC; Hayashi, K; Kawata, Y; Sakiyama, F | 1 |
| Brady, LS; Crofford, LJ; Dalakas, MC; Gold, PW; Heyes, MP; Hill, RH; Needham, LL; Page, SW; Rader, JI; Wilder, RL | 1 |
| Franke, G; Grimm, U; Knapp, A; Mellenthin, R; Seidlitz, G | 1 |
| Schwarcz, R; Speciale, C | 1 |
| Christen, S; Peterhans, E; Stocker, R | 1 |
| Chakrabarti, B; Ueno, N | 1 |
| Kimbrough, TD; Llewellyn, GC; Weekley, LB | 1 |
| Hayaishi, O; Kido, R; Takikawa, O; Yoshida, R | 1 |
| Heyes, MP; Markey, SP; Quearry, BJ | 1 |
| Fuchs, D; Hausen, A; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 1 |
| Aune, TM; Pogue, SL | 1 |
| Pearson, SJ; Reynolds, GP | 1 |
| Grimm, U; Knapp, A; Wich, H | 1 |
| Izuta, S; Shibata, Y; Takeuchi, F; Tsubouchi, R | 1 |
| Anderson, GH; Hrboticky, N; Leiter, LA | 1 |
| Brown, RR; Hank, JA; Kohler, PC; Lee, CM; Sondel, PM; Storer, BE | 1 |
| Battaini, F; Caimi, BR; Govoni, S; Ossi, C; Pinelli, A; Trivulzio, S | 1 |
| Abdel-Hamied, HA; Abdel-Tawab, GA; Aboul-Azm, T; Ebied, SA; el-Kholy, ZA; el-Sharaky, AS; el-Toukhy, MA | 1 |
| Killian, W; Rett, A; Riederer, P; Schmidt, B; Weiser, M; Wichart, I | 1 |
| Turco, J; Winkler, HH | 1 |
| Byrne, GI; Landry, GJ; Lehmann, LK | 1 |
| Eckel, M; Pfefferkorn, ER; Rebhun, S | 1 |
| Borden, EC; Brown, RR; Byrne, GI; Kirschbaum, JG; Lee, CM; Lehmann, LK | 1 |
| Duch, DS; Edelstein, MP; Ozaki, Y | 1 |
| Fuchs, D; Hausen, A; Hirsch-Kauffmann, M; Reibnegger, G; Schweiger, M; Wachter, H; Werner, ER | 1 |
| Dierich, MP; Fuchs, D; Hausen, A; Jaeger, H; Reibnegger, G; Wachter, H; Werner, ER; Werner-Felmayer, G | 1 |
| Buzdin, VV; Ivanova, NA; Nikitina, ZS; Ryzhov, IV | 1 |
| Aramsombatdee, E; Branchey, M; Buydens-Branchey, L; Lieber, CS; Worner, TM; Zucker, D | 1 |
| Brown, SJ; Friedman, MJ; Krstulovic, AM; Severinghaus, JM | 1 |
| Jirgensone, S; Jirgensons, J; Jurika, E; Rudzite, V; Sileniece, G; Zirne, R | 1 |
| Ibrahim, M; Lohmann, C; Lohmann, W | 1 |
| Bloomer, WD; Brown, RR; Dalton, J; Kalnicki, S; Lee, CM; Lehrer, S; Lipsztein, R; Song, HK | 1 |
| Alvarado, A; Bonkovsky, HL; Lincoln, BC; Setty, N | 1 |
| Chang, CC; Kawata, Y; Sakiyama, F | 1 |
| Hynninen, PH; Sainio, EL | 1 |
| Evangelista, SJ; Rogers, KS | 1 |
| Annable, L; Chouinard, G; Young, SN | 1 |
| Gu, JF; Guo, JS; Hou, XC | 1 |
| Shirasawa, E; Tomoda, A; Yoneyama, Y | 1 |
| Dillon, J; Roy, D; Spector, A | 1 |
| Ashley, DV; Leathwood, PD; Liardon, R | 1 |
| Palmieri, F; Quagliariello, E | 1 |
| Denisov, BE; Kniazev, IuA; Marchenko, LF; Vakhrusheva, LL | 1 |
| Lester, G | 1 |
| Wheelis, ML | 1 |
| Jérome, H; Kamoun, P; Lemoyne, C | 1 |
| Beattie, EJ; Grabstald, H; Lieberman, PH; Linker, DG; Melamed, MR; Watson, RC | 1 |
| Kido, R; Minatogawa, Y; Noguchi, T | 1 |
| Kido, R; Nakamura, J; Noguchi, T | 1 |
| Grimm, U; Knapp, A; Schmitz, KW; Schmitz, W; Schulz, M; Smetan, M | 1 |
| Berry, LJ | 1 |
| Beaven, V; Katz, E; Redfield, BG; Weissbach, H | 1 |
| Rose, DP | 3 |
| Glenner, GG; Hopsu, VK; Santti, R | 1 |
| Lapin, IP; Oxenkrug, GF | 1 |
| Chruściel, M | 1 |
| Brown, RR; Madsen, PO; Price, JM; Wolf, H | 1 |
| Chalmers, JG | 1 |
| Hayashi, K; Ota, M | 1 |
| Benson, EM; Edwards, MA; Miller, LT; Young, J | 1 |
| Brown, RR; Hankes, LV; Lippincott, S; Schmaeler, M | 2 |
| Arakawa, T; Morikawa, T; Tada, K | 1 |
| Pasquariello, G; Tenconi, LT | 2 |
| Colombo, JP; Gloor, RD; Rossi, E; Vassella, F | 1 |
| Brown, RR; Hankes, LV; Schiffer, L; Schmaeler, M | 1 |
| Brown, RR; Leklem, JE; Woodford, J | 1 |
| Colombini, C; Ebadi, M; McCoy, EE | 1 |
| Brown, RR; Price, JM; Rose, DP; Wolf, H | 1 |
| Bianchi-Donnasibilla, L; Curró, F; Luvara, A | 1 |
| Hochberg, K; Kochen, W | 1 |
| Brown, RR; Burney, SW; Friedell, GH; Price, JM | 1 |
| Hardy, J; Heeley, AF; Heeley, ME; Soothill, JF | 1 |
| Brown, RR; Hankes, LV; Leklem, JE; Schmaeler, M | 2 |
| Brune, GG; Brune, RM; Wiskemann, A | 1 |
| Leklem, JE | 1 |
| Brown, RR; Hankes, LV; Leklem, JE; Mekel, RC | 2 |
| Curzon, G; Green, AR | 1 |
| Berg, CP; Loh, HH | 4 |
| Alperovitch, A; Bohuon, C; Chabenat, C; Flamant, R | 1 |
| Birnbaum, D; Böttcher, F; Samsonova, IA | 1 |
| Chiancone, FM | 2 |
| Houpt, JB; Hunt, M; Ogryzlo, MA | 1 |
| Turner, JR | 1 |
| Lester, G; Russell, PJ; Schlitt, SC | 1 |
| Chen, J; Matchett, WH | 1 |
| Wolf, H | 2 |
| Kuntze, I; Schievelbein, H | 1 |
| Mandell, AJ; Rubin, RT | 1 |
| Hayaishi, O; Higuchi, K | 1 |
| McGinty, F; Rose, DP | 2 |
| Abdel-Daim, MH; Abdel-Tawab, GA; Amer, MS | 3 |
| Raine, DN | 1 |
| Brown, AT; Wagner, C | 1 |
| Braidman, IP; Rose, DP | 1 |
| Manning, B; Mason, M | 1 |
| Cole, KW; Gaertner, FH; Welch, GR | 1 |
| Brown, RR; Hankes, LV; Jansen, CR; Leklem, J; Mekel, RC | 1 |
| Scholz, G; Streffer, C | 1 |
| Streffer, C | 3 |
| Erge, D; Floss, HG; Gröger, D | 1 |
| Bückmann, D; Linzen, B; Willig, A | 1 |
| Eichelberg, D; Wessing, A | 1 |
| Eichelberg, D | 1 |
| Kim, JH; Miller, LL | 1 |
| Bonse, A | 1 |
| Dawkins, PD; McArthur, JN | 1 |
| Ford, J; Mason, M; Wu, HL | 1 |
| Beisel, WR; Rapoport, MI | 2 |
| Hardeland, R | 1 |
| Brody, S | 1 |
| Karczewski, P; Teuscher, G; Weide, H | 1 |
| Abdel-Tawab, GA; el-Sewedy, SM; el-Zoghby, SM; Mostafa, MH; Shalaby, SM; Zeitoun, R | 1 |
| Linkswiler, HM; Shin, HK | 1 |
| Ricós, C; Sabater, J | 1 |
| Grimm, U; Knapp, A; Reddemann, H; Schlenska, K; Schmitz, KW; Schulz, M; Smetan, M | 1 |
| Kido, R; Morimoto, M; Nakatani, M; Noguchi, T | 1 |
| Binazzi, M; Calandra, P; Lisi, P | 1 |
| Allegri, G; De Antoni, A | 1 |
| Chen, NC; Gholson, RK | 1 |
| Kostellow, AB; Morrill, GA | 2 |
| Jaffe, IA | 2 |
| Kruglov, BV; Lebedev, VP; Levitina, NO; Tabolin, VA | 1 |
| Mabuchi, H; Miyamoto, S; Okamoto, H; Takeda, R; Yoneyama, Y | 1 |
| Brown, RR; Karp, WB; Robertson, AF; Schuerger, GS | 1 |
| Brown, RR; Leklem, JE; Rose, DP | 1 |
| Otani, S; Perlman, D; Perlman, KL; Walker, JE | 1 |
| Elias, EG; Ezdinli, E; Gailani, S; Nussbaum, A; Silvernail, P | 1 |
| Heinmets, F | 1 |
| Lapin, IP | 1 |
| Forrest, HS; Kulkarni, AD; Phillips, JP | 1 |
| Carlson, JR; Yang, JN | 1 |
| Laborit, H; Sallé, J | 1 |
| Abdel-Tawab, GA; Kelada, FS; Konbar, AA; Moustafa, MH | 1 |
| Grimm, U; Knapp, A; Schmitz, W; Schulze, M; Wolfram, G | 1 |
| Jablonska, S; Stachow, A | 1 |
| Abul-Fadl, M; Hamza, S; Khalafallah, A; Khattab, M | 1 |
| Calandra, P; Rampichini, L; Severini, M | 1 |
| Grillo, G; Mainardi, L | 1 |
| Cruz, M; Rodríguez-Hierro, F; Torralba, A | 1 |
| Ehrhart, H | 1 |
| Bühner, R; Bührlen, E; Byrd, D; Kochen, W | 1 |
| Rose, DP; Toseland, PA | 1 |
| Czeto, AR; Morgan, RS; Strother, GK | 1 |
| Gailani, S; Kenny, G; Murphy, G; Nussbaum, A; Silvernail, P | 1 |
| Brown, RR; Carlson, IH; Davis, HL; Leklem, J | 1 |
| Grimm, U; Grosser, V; Knapp, A; Lubs, H; Wolfram, G | 1 |
| Frazer, A; Mendels, J; Pandey, GN | 1 |
| Kurzel, RB; Wolbarsht, ML; Yamanashi, BS | 1 |
| Van Heyningen, R | 1 |
| Griess, G; Schultz, J; Yulo, T; Zigman, S | 1 |
| Kondrat'ev, VG; Kontsevaia, NG; Koval'skiĭ, GS; Kureeva, RIa; Shapiro, SE | 1 |
| Nath, MC; Shastri, NV | 4 |
| Winston, F | 1 |
| Holt, LA; Milligan, B | 1 |
| Berg, CP; Rodden, FA | 1 |
| Dilley, KJ; Pirie, A | 1 |
| Payne, IR; Walsh, EM; Whittenburg, EJ | 1 |
| Lu, GH; Meyer, K; Payne, IR | 1 |
| Hankes, LV; Kido, R; Schmaeler, M | 1 |
| Allegri, G; Bordin, F; Costa, C; De Antoni, A | 1 |
| Santus, R; Walrant, P | 1 |
| Al-Hadithi, NA | 1 |
| Ikeno, T; Ishiguro, I; Matsubara, H | 1 |
| Faurbye, A | 1 |
| Linzen, B | 1 |
| Hasegawa, F; Jo, Y; Makino, K; Murakami, K; Murakami, Y | 1 |
| Abe, M; Kotake, Y; Murakami, E | 1 |
| Price, JM | 1 |
| Curzon, G | 1 |
| Bryan, GT | 1 |
| DeMoss, RD; Hoch, JA; Simpson, FJ | 1 |
| Guerdoux, JL | 1 |
| Beisel, WR; Hornick, RB; Rapoport, MI | 1 |
| Prasad, C; Srinivasan, VR | 1 |
| Kochen, W | 1 |
| Abdel-Daim, MH; Abdel-Tawab, GA; el-Sawy, MF; el-Sewedy, SM | 1 |
| Adams, PW; Rose, DP | 1 |
| Adams, PW; Harding, PE; Rose, DP; Strong, R | 1 |
| Price, SA; Rose, DP; Toseland, PA | 1 |
| Goĭkhberg, MI; Kartasheva, LA; Klimenko, IA; Martynenko, AG | 1 |
| Bruckner, FE; Chamberlain, MA; Lakatos, C; Smith, HG | 1 |
| Bois-Joyeux, B; Gaudin-Harding, F | 1 |
| Randall, ZC; Rose, DP | 1 |
| Brown, RR; Hankes, LV; Jesseph, J; Leklem, J; Schmaeler, M | 1 |
| Jori, G; Saccomani, G; Scatturin, A; Tamburro, AM; Vidali, G | 1 |
| Diethelm, L; Ladner, HA | 1 |
| Bühner, R; Kochen, W; Otting, W | 1 |
| Lardy, HA | 1 |
| Chabner, BA; DeVita, VT; Livingston, DM; Oliverio, VT | 2 |
| Albro, PW; Fishbein, L | 1 |
| Galiazzo, G; Gennari, G; Jori, G; Scoffone, E | 1 |
| Kondrat'ev, VG; Kontsevaia, NG | 1 |
| Bell, ED; Waring, WI | 1 |
| Asquith, RS; Rivett, DE | 1 |
| Pirie, A | 1 |
| Abe, M | 1 |
| Gibbs, K; Walshe, JM | 1 |
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| DALGLIESH, CE; TEKMAN, S | 1 |
| CAVALLINI, D; TENTORI, L | 1 |
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| CALLERI, A; GIOVANNINI, M; TERZOLI, S | 1 |
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| Capuron, L; Frick, B; Fuchs, D; Lawson, DH; Miller, AH; Musselman, DL; Nemeroff, CB; Schröcksnadel, K | 1 |
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| Rho, JM | 1 |
| Frick, B; Fuchs, D; Leblhuber, F; Neurauter, G; Schroecksnadel, K | 1 |
| Austin, CJ; Jamie, JF; Kosim-Satyaputra, P; Matin, A; Mizdrak, J; Parker, MW; Polekhina, G; Roberts, TH; Sirijovski, N; Truscott, RJ; Willows, RD | 1 |
| Chugani, DC | 2 |
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| Christofides, J; Darlington, LG; Egerton, M; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N | 3 |
| Fuchs, D; Schennach, H; Schroecksnadel, K; Winkler, C; Wirleitner, B | 3 |
| Fuchs, D; Greinix, H; Hainz, U; Heitger, A; Ladisch, S; Lawitschka, A; Obexer, P; Pötschger, U; Sedlmayr, P; Takikawa, O; Winkler, C | 1 |
| Fleming, AW; Fuchs, D; Neurauter, G; Pellegrin, K; Peterson, VM; Wirleitner, B | 1 |
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| Fuchs, D; Fuith, LC; Schroecksnadel, K; Winkler, C | 1 |
| Fuchs, D; Huber, R; Kemmler, G; Kohl, C; Neurauter, G; Schröcksnadel, H; Sölder, E; Sperner-Unterweger, B; Walch, T | 1 |
| Allegri, G; Bertazzo, A; Comai, S; Costa, CV; Ragazzi, E | 1 |
| Arbatova, J; D'Amato, E; Reeben, M; Vaarmann, A; Zharkovsky, A | 1 |
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| Fuchs, D; Schröcksnadel, K; Winkler, C; Wirleitner, B | 1 |
| Helin, H; Hurme, M; Oja, SS; Pertovaara, M; Pukander, J; Raitala, A; Uusitalo, H | 1 |
| Duftner, C; Fuchs, D; Schirmer, M; Schroecksnadel, K; Winkler, C; Wirleitner, B | 1 |
| Coyle, JT | 1 |
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| Alegre, E; Carosella, E; González, A; LeMaoult, J; López, AS | 1 |
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| Beadle, GW; Mitchell, HK; Nyc, JF | 1 |
| Aigner, F; Brandacher, G; Fuchs, D; Margreiter, R; Schroecksnadel, K; Schwelberger, H; Weiss, HG; Winkler, C | 1 |
| Belladonna, ML; Bianchi, R; Cavener, DR; Fallarino, F; Fioretti, MC; Grohmann, U; McGrath, BC; Orabona, C; Puccetti, P; Santamaria, P; Vacca, C; Volpi, C; You, S | 1 |
| Belladonna, ML; Bianchi, R; Fallarino, F; Fioretti, MC; Grohmann, U; Guidetti, P; Puccetti, P; Schwarcz, R; Volpi, C | 1 |
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| Forbes, MD; Sherin, PS; Snytnikova, OA; Tsentalovich, YP | 1 |
| Aldinucci, A; Biagiotti, T; Carpendo, R; Cozzi, A; Giannini, C; Laffi, G; Monti, M; Moroni, F; Rosselli, M; Zignego, AL | 1 |
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| Amori, L; Costantino, G; Guidetti, P; Marinozzi, M; Pellicciari, R; Rizzo, RC; Schwarcz, R; Wu, HQ | 1 |
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| Evans, AK; Lightman, SL; Lowry, CA; Nutt, DJ; Rook, GA; Ruddick, JP | 1 |
| Kim, YK; Leonard, B; Myint, AM; Scharpé, S; Steinbusch, H; Verkerk, R | 2 |
| Darlington, LG; Forrest, CM; Mackay, GM; Oxford, L; Stone, TW; Stoy, N | 1 |
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| Cornelio, AR; de Souza Wyse, AT; Dutra-Filho, CS; Rech, VC; Rodrigues-Junior, Vda S; Wajner, M; Wannmacher, CM | 1 |
| Bonatti, H; Bösmüller, C; Brandacher, G; Cakar, F; Fuchs, D; Margreiter, R; Obrist, P; Schneeberger, S; Werner, ER; Werner-Felmayer, G; Winkler, C | 1 |
| Anderson, SA; Boasso, A; Dolan, MJ; Fuchs, D; Hardy, AW; Herbeuval, JP; Shearer, GM | 1 |
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| Fallarino, F; Gizzi, S; Grohmann, U; Mosci, P; Puccetti, P | 1 |
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| Belladonna, ML; Fallarino, F; Fioretti, MC; Gizzi, S; Grohmann, U; Orabona, C; Pallotta, MT; Puccetti, P; Vacca, C; Volpi, C | 1 |
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| Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N | 1 |
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| Fuchs, D; Kemmler, G; Mumelter, B; Sarcletti, M; Schroecksnadel, K; Weiss, G; Winkler, C; Zangerle, R | 1 |
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| Austin, CJ; Ball, HJ; Hunt, NH; Weiser, S; Yuasa, HJ | 1 |
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| De Luca, A; Fallarino, F; Puccetti, P; Romani, L; Zelante, T | 1 |
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| Ball, HJ; Funakoshi, H; Hunt, NH; Kanai, M; McGregor, IS; McQuillan, JA; Nakamura, T; Too, LK | 1 |
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| Ando, M; Nishikawa, M; Saito, K; Takahashi, Y; Takakura, Y; Watanabe, Y; Watcharanurak, K; Yamamoto, Y; Yoshinaga, K; Zang, L | 1 |
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| Chaker, H; Genestet, C; Guery, B; Le Gouellec, A; Polack, B; Stasia, MJ; Toussaint, B | 1 |
| Berta, L; Grozdics, E; Gyarmati, B; Szalárdy, L; Toldi, G; Tulassay, T; Vécsei, L; Veres, G; Zádori, D | 1 |
| Chang, YM; El-Zaatari, M; Franz, M; Grasberger, H; Huffnagle, GB; Kamada, N; Kao, JY; Lutter, R; McDermott, AJ; Shreiner, A; van der Sluijs, KF; Young, VB; Zhang, M | 1 |
| Feng, J; Gruia, F; Li, Y; Polozova, A | 1 |
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| Darlington, LG; Forrest, CM; Khalil, OS; McNair, K; Pisar, M; Qasem, S; Stone, TW; Vincenten, MC | 1 |
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| Cai, R; Chen, J; Liu, L; Lu, H; Qi, T; Shao, J; Shen, Y; Zhang, R | 1 |
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| Berstad, A; Raa, J; Valeur, J | 1 |
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| Lin, N; Liu, S; Liu, Z; Pi, Z; Qi, Y; Song, F | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE | 1 |
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| Hashimoto, K; Shi, JY; Wang, N; Yang, C; Yang, JJ; Yu, HY | 1 |
| Eussen, SJ; Hustad, S; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE | 1 |
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| Allison, DJ; Ditor, DS | 1 |
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| Barger, GR; Chakraborty, PK; Juhász, C; Kamson, DO; Lee, TJ; Mittal, S; Muzik, O; Robinette, NL; Snyder, M; Varadarajan, K | 1 |
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| Farzi, A; Fröhlich, EE; Hassan, AM; Holzer, P; Jain, P; Mayerhofer, R; Meinitzer, A; Painsipp, E; Reichmann, F; Rinner, B; Wagner, K | 1 |
| Ballesteros, I; Cuartero, MI; de la Parra, J; García-Culebras, A; Lizasoain, I; Moro, MÁ | 1 |
| Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK | 1 |
| Cai, Z; Chen, LL; Chua, KK; Li, M; Liu, LF; Luan, H; Meng, N; Mok, VC; Song, JX; Tang, Z; Xie, LX | 1 |
| Fukuwatari, T; Ohno, T; Sano, M; Shibata, K | 1 |
| Allen, AP; Clarke, G; Cryan, JF; Dinan, TG; Kennedy, PJ; O'Neill, A; Quigley, EM | 1 |
| Chong, BH; Holmdahl, R; Maghzal, GJ; Stocker, R; Winter, S; Wurzer, B | 1 |
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| Adams, S; Braidy, N; Brew, BJ; Bustamante, S; Guillemin, GJ; Lim, CK; McDonald, KL; Sundaram, G; Teo, C; Zinger, A | 1 |
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| Abdelmoaty, S; Bhat, M; Dahl, ML; Engberg, G; Erhardt, S; Finn, A; Kegel, ME; Larsson, MK; Lundberg, K; Orhan, F; Samuelsson, M; Schuppe-Koistinen, I; Schwieler, L; Sellgren, C; Skogh, E; Svensson, C | 1 |
| Austin, CJ; Rendina, LM | 1 |
| Becker, K; Fuchs, D; Ganzera, M; Geisler, S; Gostner, JM; Schennach, H; Schroecksnadel, S; Überall, F | 1 |
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| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
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| Garg, R; Landi, A; Schulz, S; van Drunen Littel-van den Hurk, S; Wilson, JA | 1 |
| Ahmad, A; Allam, O; Ancuta, P; Baril, JG; Costiniuk, CT; El-Far, M; Jenabian, MA; Kanagaratham, C; Kema, I; LeBlanc, R; Lebouché, B; Radzioch, D; Routy, JP; Thomas, R; Tremblay, C; Vyboh, K | 1 |
| Braidy, N; Bustamante, S; Grant, R; Guillemin, GJ; Lovejoy, D; Sheipouri, D | 1 |
| Bramness, JG; Hestad, K; Lien, L; Martinez, P; Neupane, SP | 1 |
| Breukelman, H; Deelman, LE; Henning, RH; Kema, IP; Sandovici, M; Seelen, MA; Van den Eynde, BJ; van der Heuvel, MC; van Goor, H; Vavrincova-Yaghi, D | 1 |
| Beconi, M; Bonelli, F; Caretti, F; Chan, K; Dominguez, C; Herbst, T; Lyons, K; Monteagudo, E; Munoz-Sanjuan, I; Orsale, MV; Orsatti, L; Speziale, R; Toledo-Sherman, L; Veneziano, M; Zini, M | 1 |
| Dąbrowski, R; Hagman, R; Kocki, T; Pastor, J; Turski, WA; Tvarijonaviciute, A | 1 |
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| Arts, B; Drukker, M; Guloksuz, S; Kenis, G; Myint, AM; Ponds, R; Rodriguez, L; Rutten, BP; Schwarz, MJ; van Os, J; Walter, S | 1 |
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| Iida, S; Inagaki, A; Inagaki, H; Ishida, T; Ito, A; Kinoshita, S; Komatsu, H; Kusumoto, S; Maeda, Y; Masaki, A; Narita, T; Niimi, A; Ogura, H; Ri, M; Suzuki, S; Takino, H; Totani, H; Ueda, R; Utsunomiya, A; Yoshida, T | 1 |
| Brody, LC; Brosnan, JT; Brosnan, ME; Deac, OM; Fan, R; Gibney, ER; Laird, E; Midttun, Ø; Mills, JL; Molloy, AM; Shane, B; Ueland, PM; Wang, Y | 1 |
| Engin, A; Engin, AB; Karahalil, B; Karakaya, AE | 1 |
| Alonso, CM; Bradley, KA; Case, JA; Gabbay, V; Hanna, A; Khan, O; Ricart, T | 1 |
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| Ahmed, S; Cunningham, C; Griffin, ÉW; Harkin, A; Lyons, A; Murray, C; O'Loughlin, E; Sherwin, E; Stevenson, NJ | 1 |
| Ching, LM; Flanagan, JU; Kendall, JD; Palmer, BD; Tomek, P | 1 |
| da Cunha, DF; Maltos, AL; Monteiro, MC; Moraes, GV; Portari, GV; Vannucchi, H | 1 |
| Liu, D; Song, P; Wang, Q; Zou, MH | 1 |
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| Davis, I; Liu, A | 1 |
| Frugier, T; Guillemin, GJ; Heng, B; Lim, CK; Morganti-Kossmann, MC; Rosenfeld, JV; Sundaram, G; Tan, M; Walker, DW; Yan, EB | 1 |
| Ding, G; Sun, W; Wei, L; Zhang, L | 1 |
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| Horváth, Z; Tuka, B; Vécsei, L | 1 |
| Bangsberg, DR; Bennett, J; Bwana, BM; Byakwaga, H; Dollard, SC; Glidden, DV; Huang, Y; Hunt, PW; Laker-Oketta, M; Martin, JN; Mbidde, EK; Mocello, AR; Walusansa, V | 1 |
| King, NJ; Terentis, AC; Thomas, SR; Yeung, AW | 1 |
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| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Ralat, M; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
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| Asor, E; Avital, A; Ben-Shachar, D; Klein, E; Ruppin, E; Stempler, S | 1 |
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| Adamski, J; Boulet, MM; Chevrier, G; Grenier-Larouche, T; Marette, A; Nadeau, M; Pelletier, M; Prehn, C; Scarpa, J; Tchernof, A | 1 |
| Galba, J; Kovac, A; Michalicova, A; Novak, M; Parrak, V | 1 |
| Fites, JS; Minbiole, KP; Reinert, LK; Rollins-Smith, LA; Shiakolas, AR; Umile, TP | 1 |
| Aversa, F; Pieraccini, G; Romani, L; Scaringi, L; Zelante, T | 1 |
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| Costiniuk, CT; Jenabian, MA; Kema, I; Klein, MB; Mehraj, V; Paulino Ramirez, R; Rollet, K; Routy, JP; Vyboh, K | 1 |
| Arik Yilmaz, E; Baydar, T; Birben, E; Buyuktiryaki, B; Cavkaytar, O; Cetin, C; Girgin, G; Kalayci, O; Sackesen, C; Sahiner, UM; Soyer, OU; Yavuz, ST | 1 |
| Bergink, V; Burgerhout, KM; Drexhage, HA; Hoogendijk, WJ; Kushner, SA; Myint, AM; Schütze, G; Schwarz, MJ; Veen, C | 1 |
| Becker, K; Hunt, NH; Ihmels, H; Isernhagen, A; Jortzik, E; Mailu, BM; Rahlfs, S; Viola, G; Wittlin, S; Zocher, K | 1 |
| Gaardbo, JC; Midttun, Ø; Nielsen, SD; Stiksrud, B; Trøsied, M; Ueland, PM; Ullum, H | 1 |
| Dierkes, J; Drevon, CA; Gudbrandsen, OA; Karlsson, T; Midttun, Ø; Nygård, O; Pedersen, ER; Strand, E; Ueland, PM; Øyen, J | 1 |
| Gao, R; Kan, MQ; Wang, SG; Yang, RH; Zhang, SG | 1 |
| Basran, J; Booth, ES; Handa, S; Lee, M; Raven, EL | 1 |
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| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Fuchs, D; Greilberger, J; Greilberger, M; Leblhuber, F; Rommer, PS; Schroth, R; Tafeit, E | 1 |
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| Anderson, G; Bellivier, F; Geoffroy, PA; Jacob, A | 1 |
| de Bie, J; Grant, R; Guest, J; Guillemin, GJ | 1 |
| Brandão, ML; Carabelli, B; Cunha, JM; Cunha, TM; da Silva Dias, IC; de Carvalho, MC; de Morais, H; Ferraz, AC; Ishii, DK; Rizzo de Souza, LE; Zanata, SM; Zanoveli, JM | 1 |
| Azzinnari, D; Bergamini, G; Cathomas, F; Ceci, A; Fuertig, R; Hengerer, B; Luippold, A; Pryce, CR; Seifritz, E; Sigrist, H; Vavassori, S | 1 |
| Fujigaki, H; Saito, K; Yamamoto, Y | 1 |
| Dabrowska, M; Jasiewicz, M; Kaminski, KA; Kazimierczyk, R; Knapp, M; Moniuszko, M; Musial, WJ; Pawlak, D; Rusak, M | 1 |
| Kaminski, T; Michalowska, M; Oksztulska-Kolanek, E; Pawlak, D; Znorko, B | 1 |
| De Picker, L; Dedeurwaerdere, S; Kosten, L; Staelens, S; Stroobants, S; Thomae, D; Van Eetveldt, A; Verhaeghe, J; Verkerk, R; Wyffels, L | 1 |
| Alyanakian, MA; Aouba, A; Bachmeyer, C; Barète, S; Bonin, B; Chandesris, MO; Chauvet-Gelinier, JC; Côté, F; Damaj, G; Dubreuil, P; Gaillard, R; Georgin-Lavialle, S; Grandpeix-Guyodo, C; Haffen, E; Hermine, O; Launay, JM; Lortholary, O; Moura, DS; Salvador, A; Soucié, E; Teyssier, JR; Trojak, B; Vandel, P | 1 |
| Aznar-Laín, G; Gonzalez-Sepulveda, M; Gracia-Rubio, I; Marcos, J; Pérez-Jurado, LA; Pozo, OJ; Renau, N; Segura, J; Valverde, O; Ventura, R | 1 |
| Eussen, SJ; Meyer, K; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE; Zuo, H | 1 |
| Barète, S; Canioni, D; Chandesris, MO; Côté, F; Damaj, G; Dubreuil, P; Georgin-Lavialle, S; Hanssens, K; Hermine, O; Launay, JM; Lortholary, O; Moura, DS; Sokol, H; Soria, A; Soucié, E | 1 |
| Fukushima, T; Ichiba, H; Iizuka, H; Kuwabara, R; Miyagi, A; Naito, Y; Onozato, M; Sakamoto, T; Takahashi, S | 1 |
| Becker, K; Fuchs, D; Gostner, JM; Strasser, B | 1 |
| Bhat, M; Erhardt, S; Frye, MA; Johansson, AG; Jungholm, O; Landén, M; Samuelsson, M; Schuppe-Koistinen, I; Schwieler, L; Sellgren, CM | 1 |
| Bassett, E; Chakravarti, A; Fischer, SM; Gordon, N; Jacob, JR; Kanji, S; Lautenschlaeger, T; Litzenberg, KT; Palanichamy, K; Patel, D; Ramasubramanian, B; Ray-Chaudhury, A; Sebastian, N; Singh, R; Thirumoorthy, K | 1 |
| Antunes, MS; Boeira, SP; de Oliveira Espinosa, D; Donato, F; Giacomeli, R; Gomes, NS; Jesse, CR; Ruff, JR; Souza, LC | 1 |
| Brew, BJ; Guillemin, GJ; Jacobs, K; Lennon, MJ; Lim, CK; Lovelace, MD; Sundaram, G; Varney, B | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M | 1 |
| Grzegorzewski, WJ; Kozlowska, A; Lepiarczyk, E; Majewski, M; Thoene, M | 1 |
| Dursun, A; Engin, A; Engin, AB; Gonul, II; Karamercan, A; Sepici Dincel, A | 1 |
| Byakwaga, H; Haas, DW; Huang, Y; Hunt, PW; Kroetz, DL; Kubo, M; Lee, SA; Martin, JN; Mclaren, PJ; Mefford, JA; Mushiroda, T; Witte, JS | 1 |
| Dhandapani, H; Hascitha, J; Jayavelu, S; Priya, R; Rajkumar, T; Selvaluxmy, G; Sunder Singh, S | 1 |
| Bertazzo, A; Comai, S; Côté, G; Daigle, M; Gobbi, G; Toupin, J; Turecki, G; Vachon, J | 1 |
| Burtscher, M; Fuchs, D; Gatterer, H; Geiger, D; Schauer, M; Strasser, B | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M | 1 |
| Can, A; Chiappelli, J; Du, X; Fuchs, D; Hong, LE; Kochunov, P; Lowry, CA; Postolache, TT; Rowland, LM; Savransky, A; Shukla, DK; Tagamets, M; Wijtenburg, SA | 1 |
| Guastella, AR; Juhász, C; Klinger, NV; Kupsky, WJ; Michelhaugh, SK; Mittal, S; Muzik, O; Polin, LA | 1 |
| Fukuwatari, T; Kuroki, Y; Mori, N; Sekine, A; Urata, T | 1 |
| Fülöp, F; Klivényi, P; Szalárdy, L; Toldi, J; Vécsei, L; Veres, G; Zádori, D | 1 |
| Brechbiel, MW; Donahue, RN; Fantini, M; Fernando, RI; Grenga, I; Gulley, JL; Heery, CR; Hodge, JW; Jochems, C; Kim, YS; Kwilas, AR; Lepone, LM; Madan, RA; Newton, R; Schlom, J; Tsang, KY | 1 |
| Birner, CM; Bouazzaoui, A; Endemann, DH; Holler, E; Maier, LS; Schach, C; Schmid, K; Schmid, PM | 1 |
| Budac, DP; Elfving, B; Eskelund, A; Sanchez, C; Wegener, G | 1 |
| Dekker, FW; Franssen, CF; Haverkamp, GL; Honig, A; Kema, IP; Loosman, WL; Siegert, CE; van Diepen, M | 1 |
| Håberg, SE; Karlstad, Ø; London, SJ; Magnus, MC; Midtun, Ø; Nafstad, P; Nilsen, RM; Nystad, W; Parr, CL; Tunheim, G; Ueland, PM | 1 |
| Braidy, N; Brew, BJ; Guillemin, GJ; Lee, JM; Lovejoy, D; Rowe, DB; Tan, V | 1 |
| Alonso, J; Aryee, DN; Erhardt, S; Fuchs, D; Goiny, M; Katschnig, AM; Kauer, MO; Kovar, H; Kromp, F; Mutz, CN; Schwentner, R | 1 |
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| Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R | 1 |
| Allorge, D; Caiazzo, R; Favennec, M; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Raverdy, V; Verbanck, M; Verkindt, H; Yengo, L | 1 |
| Badawy, AA; Moffett, JR; Namboodiri, AM | 1 |
| Brenner, LA; Cook, TB; Eaton, WW; Friedl, M; Fuchs, D; Giegling, I; Groer, M; Hartmann, AM; Hoisington, AJ; Kelly, DL; Konte, B; Lowry, CA; Okusaga, O; Pandey, JP; Postolache, TT; Reeves, G; Rujescu, D; Stearns-Yoder, KA | 1 |
| Kubo, H; Ohashi, K; Ohta, Y; Saito, K; Tsuzuki, Y; Wada, N; Yamamoto, Y; Yashiro, K | 1 |
| Brunet-Vega, A; Calvet, X; Gombau, L; Junquera, F; Kuligowski, J; Lario, S; Pericay, C; Quintás, G; Ramírez-Lázaro, MJ; Sanjuan-Herráez, D; Vázquez-Sánchez, MA | 1 |
| Allorge, D; Bortolotti, P; Dessein, R; Faure, E; Faure, K; Grandjean, T; Guery, BP; Hennart, B; Jausions, G; Kipnis, E; Le Gouellec, A; Thepaut, M; Thieffry, C; Toussaint, B | 1 |
| Engberg, G; Erhardt, S; Goiny, M; Liu, XC; Mathé, AA | 1 |
| Fujigaki, H; Imamura, Y; Ishibashi, T; Kim, HC; Kubo, H; Mamiya, T; Mitani, S; Murakami, Y; Nabeshima, T; Nishikawa, M; Ohta, Y; Saito, K; Takahashi, Y; Takakura, Y; Tashiro, T; Tomita, E; Watcharanurak, K; Yamamoto, Y | 1 |
| Caruso, JA; Deepe, GS; George, MM; Landero Figueroa, JA; Subramanian Vignesh, K | 1 |
| Celik, H; Huysal, K; Kahvecioglu, S; Kivrak, I; Kivrak, S; Ustundag, Y; Yilmaz, N | 1 |
| Challa, S; Madigubba, S; Panigrahi, M; Phanithi, PB; Talari, NK | 1 |
| Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM | 1 |
| Genet, M; Gritsina, G; James, CD; Ladomersky, E; Lauing, KL; Wainwright, DA; Wu, M; Zhai, L | 1 |
| Guo, J; Han, JF; Pan, W; Sun, KJ; Wang, J; Xie, ZM; Yang, JJ; Zhang, GF | 1 |
| Asayag, CR; Bream, JH; Caulfield, LE; Gratz, J; Kosek, MN; Kosek, PS; Lee, GO; Mduma, E; Olortegui, MP; Pan, WKY; Patil, C; Sanchez, GM; Svensen, E; Yori, PP | 1 |
| Bezard, E; Camus, SM; Ceci, A; Fuertig, R; Hengerer, B; Luippold, AH | 1 |
| Fuchs, D; Gostner, JM; Gualdoni, GA; Zlabinger, GJ | 1 |
| Bahonjic, A; Doehner, W; Fritschi, N; Fusch, G; Pschowski, R; Schefold, JC; Schroeder, T; Storm, C; von Haehling, S | 1 |
| Hu, JQ; Hu, LJ; Huang, XN; Li, XF; Lin, CX; Lu, HY; Ni, XJ; Shang, DW; Wang, JJ; Wen, YG | 1 |
| Bhat, M; Erhardt, S; Orhan, F; Piehl, F; Sandberg, K; Schwieler, L; Ståhl, S; Svensson, C | 1 |
| Antunes, M; Boeira, SP; de Gomes, MG; Del Fabbro, L; Donato, F; Filho, CB; Giacomeli, R; Goes, ATR; Jesse, CR; Luchese, C; Roman, SS; Souza, LC | 1 |
| Aldajani, WA; Ghaemmaghami, AM; Knox, A; Salazar, F; Sewell, HF | 1 |
| Benedetti, F; Bollettini, I; Colombo, C; Grillitsch, D; Locatelli, C; Mazza, E; Myint, AM; Poletti, S; Schüetze, G; Schwarz, M | 1 |
| Cobb, SR; Dalton, RN; Darlington, LG; Forrest, CM; Kennedy, PG; Rodgers, J; Stone, TW; Turner, C | 1 |
| Barat, P; Brossaud, J; Capuron, L; Corcuff, JB; Fuchs, D; Meiffred, MC; Thibault, H | 1 |
| Kim, YK; Won, E | 1 |
| Imamura, Y; Mouri, A; Murakami, Y; Nabeshima, T; Saito, K; Tashiro, T; Yamamoto, Y | 1 |
| Albini, E; Antognelli, C; Belladonna, ML; Bianchi, R; Fallarino, F; Gargaro, M; Grohmann, U; Macchiarulo, A; Mondanelli, G; Orabona, C; Pallotta, MT; Puccetti, P; Rosini, V; Vacca, C; Volpi, C | 1 |
| Batabyal, D; Chiang, BY; Correia, MA; Forouhar, F; Hussain, M; Karkashon, S; Kim, SM; Lew, S; Lewis-Ballester, A; Seetharaman, J; Tong, L; Wang, Y; Yeh, SR | 1 |
| Al-Dhabi, NA; Bai, M; Duraipandiyan, V; Liu, G; Liu, H; Oso, AO; Tossou, MC; Wu, X; Xi, Q; Xu, K; Yin, Y | 1 |
| Barone, PR; Belzung, C; Callebert, J; Guillemin, GJ; Laugeray, A; Launay, JM; Mutlu, O | 1 |
| Hrydziuszko, O; Kirwan, J; Laing, R; Mirza, DF; Murphy, N; Perera, MT; Richards, DA; Silva, MA; Viant, MR | 1 |
| Barar, J; Johari-Ahar, M; Karami, P; Majidi, MR; Omidi, Y | 1 |
| Bamford, DH; Bugai, A; De Brabander, J; Fu, Y; Gaelings, L; Hukkanen, V; Julkunen, I; Kainov, DE; Kuisma, M; Le Goffic, R; Lorey, MB; Marjomäki, V; Matikainen, S; Miller, MS; Nandania, J; Nyman, TA; Paavilainen, H; Saelens, X; Schepens, B; Söderholm, S; Tynell, J; Vande Ginste, L; Velagapudi, V | 1 |
| Burtscher, M; Fuchs, D; Gatterer, H; Geiger, D; Gostner, JM; Schauer, M; Strasser, B | 1 |
| Huston, WM; Katouli, M; Taing, K; Timms, P; Ziklo, N | 1 |
| Avelino-Silva, VI; Caiaffa-Filho, HH; Cerqueira, NB; Costa, DA; Dias, JZ; Freire, MS; Hong, MA; Huang, Y; Hunt, PW; Kallas, EG; Lima, SB; Miyaji, KT; Nishiya, AS; Sabino, EC; Sartori, AM; Simoes, M | 1 |
| Bowman, KJ; Chen, X; Leopold, L; Maleski, J; Shi, JG; Yeleswaram, S | 1 |
| Dalton, RN; Forrest, CM; Kennedy, PGE; Rodgers, J; Sternberg, JM; Stone, TW; Turner, C | 1 |
| Bernasconi, L; Christ-Crain, M; Henzen, C; Hoess, C; Huber, A; Meier, MA; Mueller, B; Ottiger, M; Schuetz, P; Steuer, C; Thomann, R; Vögeli, A; Zimmerli, W | 2 |
| Alexeev, EE; Battista, KD; Colgan, SP; Curtis, VF; Gerich, ME; Glover, LE; Kao, DJ; Kitzenberg, DA; Kominsky, DJ; Lanis, JM | 1 |
| Culig, Z; Fritz, J; Fuchs, D; Heidegger, I; Klocker, H; Pichler, R; Steiner, E | 1 |
| Barik, S; Rabbani, MAG | 1 |
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| Boergeling, Y; Ludwig, S | 1 |
| Boeira, SP; de Gomes, MG; Jesse, CR; Mattos, E; Silva, NC; Souza, LC; Viana, CE | 1 |
| Bartosiewicz, J; Kaminski, T; Karbowska, M; Pawlak, D; Pawlak, K; Tankiewicz-Kwedlo, A | 1 |
| Dušková, M; Humlová, Z; Klamová, H; Kujovská-Krčmová, L; Petráčková, M; Procházka, B; Vonka, V | 1 |
| Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Kapfhammer, HP; Maget, A; Mangge, H; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, B; Reininghaus, EZ; Schütze, G; Schwarz, M; Zelzer, S | 1 |
| Bannert, E; Breves, G; Dänicke, S; Frahm, J; Hüther, L; Kahlert, S; Kersten, S; Kluess, J; Renner, L; Rothkötter, HJ; Tesch, T | 1 |
| Ramprasath, T; Song, P; Wang, H; Zou, MH | 1 |
| Bangsberg, DR; Boum, Y; Burdo, TH; Byakwaga, H; Cao, H; Haberer, JE; Huang, Y; Hunt, PW; Kembabazi, A; Lederman, MM; Lee, S; Martin, JN; Tracy, RP; Williams, KC | 1 |
| Beaufils, B; Binnie, M; Bouillot, A; Denis, AA; Hann, MM; Haslam, CP; Holmes, DS; Hutchinson, JP; Kranz, M; Liddle, J; McBride, A; Mirguet, O; Mole, DJ; Mowat, CG; Pal, S; Rowland, P; Trottet, L; Uings, IJ; Walker, AL; Webster, SP | 1 |
| Cheng, J; Gao, X; Hou, X; Jin, H; Lv, J; Zheng, G | 1 |
| Abautret-Daly, Á; Connor, TJ; de Francisco-García, R; Dempsey, E; Harkin, A; Medina, C; Parra-Blanco, A; Riestra, S; Rodrigo, L | 1 |
| Brown, J; Finkelstein, FO; Garimella, PS; Handelman, GJ; Ikizler, A; Ix, JH; Kooman, J; Kotanko, P; Levin, NW; Malhotra, R; Persic, V; Rosales, L; Tao, X; Thijssen, S; Unruh, ML; Zhang, W | 1 |
| Chen, S; Liu, G; Teng, K; Yin, Y; Zhong, J | 1 |
| Levy, HL; Murali, SG; Nair, N; Ney, DM; Rohr, F; Sawin, EA; Stroup, BM | 1 |
| Boulet, L; Ducros, V; Faure, P; Flore, P; Montérémal, J | 1 |
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| Boeira, SP; de Gomes, MG; Del Fabbro, L; Donato, F; Filho, CB; Goes, AR; Jesse, CR; Puntel, RL; Souza, LC | 1 |
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| Carrillo Mora, P; García Muñoz, I; García-Juárez, B; Gómez-Manzo, S; González-Esquivel, D; Jiménez Herrera, B; Marcial-Quino, J; Pérez de la Cruz, G; Pérez de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Ramos-Chávez, LA; Ríos, C; Roldán-Roldán, G; Sánchez Chapul, L | 1 |
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| Ait-Belkacem, R; Gomes, B; Marillier, R; Poncelet, L; Stauber, J | 1 |
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| Chang, HS; Hu, KL; Li, LN; Lu, Y; Wang, PP; Yu, X; Zhang, B | 1 |
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| Albanes, D; Alcala, K; Arslan, AA; Blot, WJ; Brennan, P; Buring, JE; Cai, Q; Caporaso, NE; Fanidi, A; Freedman, ND; Gao, YT; Gaziano, JM; Giles, GG; Grankvist, K; Haiman, CA; Han, J; Hodge, AM; Huang, JY; Hveem, K; Johansson, M; Koh, WP; Lan, Q; Langhammer, A; Larose, TL; Le Marchand, L; Lee, IM; Li, HL; Luu, HN; Manjer, J; Midttun, Ø; Pettinger, M; Prentice, RL; Purdue, MP; Relton, C; Sesso, HD; Severi, G; Shu, XO; Stampfer, MJ; Stevens, VL; Thomson, CA; Ueland, PM; Ulvi, A; Visvanathan, K; Wang, R; Weinstein, SJ; Wilkens, LR; Wu, J; Xiang, YB; Yuan, JM; Zeleniuch-Jacquotte, A; Zhang, X; Zheng, W; Ziegler, RG | 1 |
| Han, XM; Lu, YN; Qin, YJ; Rang, Y; Wang, NX; Zhai, XJ; Zhang, XL; Zhu, Y | 1 |
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| Brix, S; Chen, C; Chen, Y; Dang, Y; Fan, Y; Gao, C; Guo, L; Guo, R; He, X; Jia, H; Jie, Z; Ju, Y; Kristiansen, K; Liu, B; Ma, Q; Ma, X; Madsen, L; Sun, Q; Wang, J; Wang, Q; Wang, W; Xiao, L; Xie, Y; Xu, X; Yang, H; Yang, L; Yang, Z; Zhang, T; Zhao, B; Zhu, F | 1 |
| Coppens, V; de Boer, P; Fransen, E; Lai, FY; Morrens, M; Sabbe, B; Schuermans, J; Timmers, M; van den Ameele, S; van Diermen, L; van Nuijs, AL; Verkerk, R | 1 |
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| Däbritz, J; Günther, J; Wirthgen, E | 1 |
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| Fujigaki, H; Hoshi, M; Kunisawa, K; Mouri, A; Nabeshima, T; Nakamoto, K; Saito, K; Yamamoto, Y; Yamasuge, W | 1 |
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| Bellmann-Weiler, R; Fuchs, D; Kurz, K; Pizzini, A; Santifaller, J; Theurl, I; Tschurtschenthaler, C; Weiss, G | 1 |
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| Abdalla, A; Brooks, EL; Mutengwa, VS; Patel, BA; Yeoman, MS | 1 |
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| McCann, A; Meyer, K; Midttun, Ø; Nygård, O; Tell, G; Ueland, PM; Ulvik, A | 1 |
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| Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM | 1 |
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| Laury-Kleintop, L; Prendergast, GC; Thomas, S | 1 |
| Bell, A; Cardoza, K; Dussold, C; Ladomersky, E; Lauing, KL; Qian, J; Wainwright, DA; Zhai, L | 1 |
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| Ballard, ED; Deng, ZD; Farmer, CA; Gold, PW; Henter, ID; Kadriu, B; Kraus, C; Machado-Vieira, R; Moaddel, R; Park, LT; Shovestul, B; Yuan, P; Zarate, CA | 1 |
| Fulzele, S; Hamrick, MW; Isales, CM; Johnson, M; Kaiser, H; McGee-Lawrence, ME; Mendhe, B; Pandya, C; Yu, K | 1 |
| Erhardt, S; Goiny, M; Imbeault, S; Liu, X | 1 |
| Kim, BJ; Koh, JM; Lee, SH | 1 |
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| Boros, FA; Vécsei, L | 2 |
| Hamrick, MW; Kaiser, H; Parker, E | 1 |
| Dos Santos, RO; Ferreira, MU; Gonçalves-Lopes, RM; Lalwani, P; Lima, NF; Scopel, KKG | 1 |
| Hinterwimmer, L; Jaschinski, F; Klar, R; Michel, S; Schell, M; Zippelius, A | 1 |
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| Crosignani, S; Driessens, G; Frederix, K; Hoffmann, D; Pilotte, L; Preillon, J; Schramme, F; Stroobant, V; Van den Eynde, BJ | 1 |
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| Farzi, A; Gao, K; Mu, CL; Zhu, WY | 1 |
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| Bollag, WB; Davis, C; Hamrick, MW; Hill, WD; Isales, CM; Johnson, MH; Kaiser, H; Kendall, RK; McGee-Lawrence, ME; Pierce, JL; Roberts, RL; Yu, K | 1 |
| Dietze, J; Heiland, I; Mohapatra, SR; Opitz, CA; Poschet, G; Sadik, A; Tykocinski, LO | 1 |
| Clanchy, FI; Huang, YS; Ogbechi, J; Stone, TW; Topping, LM; Williams, RO | 1 |
| Mroczka, R; Sadok, I; Staniszewska, M; Tyszczuk-Rotko, K | 1 |
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| Baer, W; Felger, JC; Goldsmith, DR; Haroon, E; Miller, AH; Patel, T; Welle, JR; Woolwine, BJ | 1 |
| Lee, AY; Lee, CH; Lee, WL; Park, HG; Park, SA; Son, SY | 1 |
| Castro-Portuguez, R; Sutphin, GL | 1 |
| Chen, X; Chen, Y; Gui, S; Liu, L; Liu, Y; Pu, J; Ran, Y; Song, X; Tian, L; Wang, H; Xie, P; Xu, S; Yang, L; Yu, Y; Zhang, H; Zheng, P; Zhong, X | 1 |
| Albini, E; Annunziato, L; Belladonna, ML; Bianchi, R; Boscia, F; Calabresi, P; Carvalho, A; Coletti, A; Cunha, C; Di Filippo, M; Fallarino, F; Gaetani, L; Gargaro, M; Greco, FA; Grohmann, U; Iacono, A; Iamandii, IM; Macchiarulo, A; Maciel, P; Manni, G; Matino, D; Mondanelli, G; Orabona, C; Pallotta, MT; Panfili, E; Peppelenbosch, M; Proietti, E; Puccetti, P; Santambrogio, L; Vacca, C; Volpi, C | 1 |
| Bellet, MM; Borghi, M; Cellini, B; Costantini, C; Keller, N; Pariano, M; Renga, G; Romani, L; Stincardini, C; Zelante, T | 1 |
| Classen, CF; Domanska, G; Gesche, J; Irmscher, N; Junghanss, C; Kehnscherper, H; Maletzki, C; Riess, C; Schneider, B; Shokraie, F; Strüder, D; Wirthgen, E; Zimpfer, A | 1 |
| Chen, JP; Deng, CZ; Guo, SJ; Han, H; Huang, KB; Li, YH; Li, ZS; Liu, RY; Liu, TY; Liu, ZW; Lu, JB; Qin, ZK; Yao, K; Ye, YL; Zhou, FJ; Zhou, QH | 1 |
| Fong, SSM; Kwok, MK; Li, M; Schooling, CM | 1 |
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| Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R | 1 |
| Egger, EM; Fuchs, D; Kink, P; Kurz, K; Lanser, L; Weiss, G; Willenbacher, W | 1 |
| Dashti, S; Ghafouri-Fard, S; Kholghi Oskooei, V; Samsami, M; Taheri, M; Taherian-Esfahani, Z | 1 |
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| Grishanova, AY; Perepechaeva, ML | 1 |
| Avagliano, C; Cervenka, S; Erhardt, S; Häggkvist, J; Johnström, P; Kondrashov, M; Krasikova, R; Petukhov, M; Revunov, E; Schou, M; Tari, L; Tóth, M; Vazquez-Romero, A | 1 |
| Fan, N; Lu, H; Luo, Y; Ni, X; Wen, Y; Zhang, M; Zhang, Z | 1 |
| Araos, P; Colado, MI; Flores-López, M; García-Marchena, N; O'Shea, E; Pavón, FJ; Requena-Ocaña, N; Rodríguez de Fonseca, F; Rubio, G; Serrano, A; Suárez, J; Vidal, R | 1 |
| Bédos, JP; Bruneel, F; Henry-Lagarrigue, M; Legriel, S; Soppelsa, F; Spreux-Varoquaux, O; Troché, G; Yehia, A | 1 |
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| Alekar, S; Cloughesy, T; Desjardins, A; Lassman, AB; Li, R; Reardon, DA; Rixe, O; Taylor, CT; Williams, JH | 1 |
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| Jones, DP; Liang, Y; Liu, KH; Ma, C; Nellis, M; Tran, V; Uppal, K; Walker, DI | 1 |
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| Bertolone, L; D'Alessandro, A; Francis, RO; Hansen, KC; Hod, EA; Hudson, KE; Nemkov, T; Reisz, JA; Spitalnik, SL; Stefanoni, D; Thomas, T; Zimring, JC | 1 |
| Anderson, JF; Dahmani, M; Neelakanta, G; Sultana, H | 1 |
| Chen, S; Jiang, S; Jin, R; Jin, Z; Li, H; Li, W; Liu, J; Liu, LL; Piao, L; Ren, J; Shao, Y; Wang, H; Wu, B; Zhang, Y; Zhong, S | 1 |
| Doorenbos, AZ; Heinsberg, LW; Jang, MK; Li, H; Liu, T; Lockwood, MB; Wainwright, DA | 1 |
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| Benkowitz, P; Cheng, Y; Köttgen, A; Lamina, C; Li, Y; Sekula, P | 1 |
| Carrico, AW; Chahine, A; Cohn, M; Dilworth, SE; Fuchs, D; Gouse, H; Lee, J; Lee, JY; Magidson, JF; Meade, CS | 1 |
| Allwright, M; Austin, PJ; Bailey, D; Fiore, NT; Georgius, P; Guennewig, B; Guillemin, GJ; Heng, B; Latini, A; Pires, AS; Russo, MA; Santarelli, DM; Tan, VX | 1 |
| Chen, ST; Hong, ZK; Li, SY; Quan, S; Wang, PC; Yang, ZM; Yang, ZS | 1 |
| Engblom, J; Gjörloff Wingren, A; Gustafsson, A; Jankovskaja, S; Ohlsson, L; Prgomet, Z; Ruzgas, T | 1 |
| Baumgartner, R; Berg, M; Forteza, MJ; Hansson, GK; Hedin, U; Hjorth, SA; Ketelhuth, DFJ; Matic, L; Paulsson-Berne, G; Polyzos, KP; Schwartz, TW | 1 |
| Chan, ECY; Chen, KW; Chia, JY; Chiong, E; Chionh, BJ; Choo, SN; Esuvaranathan, K; Goh, BYS; Kioh, DYQ; Lee, SH; Lim, YX; Mahendran, R; Mallari, JZ; Periaswami, R; Raman, L; Tay, MHW; Tham, SM; Thamboo, TP; Tsang, WC; Wu, QH | 1 |
| Adu-Gyamfi, CG; Chaisson, R; Darboe, F; Fisher, M; George, JA; Hoffmann, C; Makhathini, L; Martinson, N; Otwombe, K; Penn-Nicholson, A; Savulescu, D; Scriba, TJ; Snyman, T; Suchard, MS | 1 |
| Abadir, PM; Chung, T; de Cabo, R; Ferrucci, L; Hoke, A; Joca, H; Khadeer, M; Le, A; Lovett, J; Moaddel, R; Tian, J; Walston, J; Ward, C; Westbrook, R; Xue, QL; Yang, H | 1 |
| Cylwik, B; Domaniewski, T; Kalaska, B; Mor, A; Pawlak, D; Pawlak, K; Sieklucka, B; Zieminska, M | 1 |
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| Cuellar Leal, VA; Dantzer, R; de Dios, C; Hunt, C; Macedo E Cordeiro, T; Selvaraj, S; Soares, JC; Suchting, R; Teixeira, AL | 1 |
| Aslamkhan, AG; Bass, A; Bhatt, B; Garfinkel, I; Glaab, WE; LaFranco-Scheuch, L; Li, N; Loughlin, A; Miller, JR; Pacchione, S; Pearson, K; Reynolds, S; Solban, N; Styring, TG; Vu, H; Xu, Q; Zhou, H | 1 |
| Davidson, JA; DiMaria, MV; Frank, BS; Khailova, L; Klawitter, J; Mitchell, MB; Morgan, GJ; Sabapathy, D; Silveira, L; Twite, M | 1 |
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| Gerli, R; Grohmann, U; Pallotta, MT; Panfili, E | 1 |
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| Kocki, T; Komsta, Ł; Skibiński, R; Turski, WA; Wicha-Komsta, K | 1 |
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| Cho, SJ; Choi, AMK; Harris, R; Hong, KS; Lee, S; Schenck, E; Stout-Delgado, H; Yang, J | 1 |
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| Chan, LY; Chiu, YC; Chou, YH; Hu, LY; Liou, YJ; Liu, MN; Yang, BH; Yang, KC | 1 |
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| Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C | 1 |
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| Bao, W; Boerwinkle, E; Burk, RD; Cai, J; Chai, JC; Chen, GC; Clish, CB; Daviglus, ML; Dupuis, J; Feofanova, EV; Gerszten, RE; Grove, ML; Hu, FB; Hu, J; Kaplan, RC; Knight, R; Li, J; Manson, JE; Martínez-González, MA; Meigs, JB; Merino, J; Moon, JY; Nguyen, NQ; Perkins, DL; Porneala, BC; Qi, Q; Rebholz, C; Rexrode, KM; Ruiz-Canela, M; Salas-Salvadó, J; Selvin, E; Thyagarajan, B; Usyk, M; Wang, T; Wang, TJ; Wang, W; Wang, Z; Yu, B | 1 |
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| Bencsik, K; Fricska-Nagy, Z; Sandi, D; Vécsei, L | 1 |
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| Fu, J; Hu, B; Jiang, YH; Liu, CL; Qin, WH; Wang, HY | 1 |
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| Alonso-Gómez, A; Aros, F; Clish, CB; Corella, D; Dennis, C; Estruch, R; Fiol, M; Fitó, M; Gómez-Gracia, E; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Lapetra, J; Li, J; Liang, L; Martínez-González, MA; Razquin, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Serra-Majem, L; Toledo, E; Wittenbecher, C | 1 |
| Bagheri, M; Davis, LK; Ferguson, JF; Gerszten, RE; Hebbring, S; Jarvik, GP; Manouchehri, A; Mosley, JD; Murphy, MB; Murray, KT; Reilly, MP; Shaffer, CM; Shi, M; Singh, K; Stanaway, IB; Wang, C; Wang, TJ | 1 |
| Abusoglu, G; Abusoglu, S; Albayrak Gezer, I; Eryavuz Onmaz, D; Humeyra Yerlikaya, F; Isik, K; Sivrikaya, A; Tezcan, D; Unlu, A | 1 |
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| Grondin, JA; Haq, S; Khan, WI | 1 |
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| Chang, Y; Jia, C; Li, S; Wang, X; Wang, Y; Wei, W; Yang, X; Zhang, B; Zhao, Y | 2 |
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| Basran, J; Booth, ES; Campbell, LP; Clayden, J; Jesani, MH; Kwon, H; Moody, PCE; Mowat, CG; Raven, EL; Thackray, SJ | 1 |
| Akpan, IJ; Buehler, PW; Cendali, FI; D'Alessandro, A; Francis, RO; Gamboni, F; Hod, EA; Hudson, KE; Kahn, S; Katneni, U; Moriconi, C; Nemkov, T; Reisz, JA; Roh, D; Spitalnik, SL; Tanaka, K; Thangaraju, K; Thomas, T; Valk, JE; Wei, AZ; Zimring, JC | 1 |
| Fukushima, T; Kohwi-Shigematsu, T; Kondo, M; Mikami, T; Onozato, M; Tanaka, Y | 1 |
| Blasiak, J; Chojnacki, C; Chojnacki, J; Fila, M; Pawlowska, E; Szczepanska, J | 1 |
| Bollag, WB; Cantu, N; Fulzele, S; Hamrick, MW; Hill, WD; Isales, CM; Kolhe, R; Kumar, S; McGee-Lawrence, ME; Vyavahare, S | 1 |
| Boeldt, DS; Lei, W; Li, HH; Wang, K; Wei, YY; Zhao, YJ; Zheng, J; Zhou, C | 1 |
| Luo, Y; Möhn, N; Peßler, F; Senel, M; Skripuletz, T; Stangel, M; Sühs, KW; Tumani, H | 1 |
| Coppens, V; De Picker, L; Leboyer, M; Morrens, M; Müller, N; Skorobogatov, K; Verkerk, R | 1 |
| Han, YM; Ramprasath, T; Yu, CJ; Zhang, D; Zou, MH | 1 |
| Averill, LW; Falchek, SJ; Kandula, VVR; Kecskemethy, HH; Langhans, SA; Nikam, RM; Yue, X | 1 |
| Handy, DE; He, H; Lee, LY; Loscalzo, J; Mulhern, R; Oldham, WM; Wang, R | 1 |
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| Chen, W; Fang, J; Feng, C; Han, Y; Hou, P; Liu, Z; Melino, G; Shao, C; Shi, Y; Verkhratsky, A; Wang, Y; Xu, C; Zuo, M | 1 |
| Amacher, SA; Beck, K; Becker, C; Bernasconi, L; Gross, S; Hochstrasser, S; Hunziker, S; Loretz, N; Marsch, S; Metzger, K; Mueller, J; Neyer, P; Pargger, H; Schuetz, P; Sutter, R; Tisljar, K; Vincent, A | 1 |
| Ciapała, K; Mika, J; Rojewska, E | 1 |
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| Barros, SBM; Campa, A; Castilho, GA; Cavalcante, J; Clara, RO; Ferreira Branquinho, MS; Maria-Engler, SS; Silva, MBB | 1 |
| Arinze, N; Belghasem, M; Chitalia, VC; Dember, LM; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Ravid, K; Richards, S; Russell, TL; Walker, JA; Whelan, SA; Yoo, SB | 1 |
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| Anderson, S; Arinze, NV; Belghasem, M; Chitalia, VC; Farber, A; Francis, J; Hamburg, NM; Hassan Kamel, M; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Rahimi, N; Ravid, JD; Richards, S; Sherr, D; Siracuse, JJ; Walker, JA; Whelan, SA; Yin, W | 1 |
| Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T | 1 |
| Ataei, S; Azcarate-Peril, A; Carroll, I; Fransson, E; Jin, W; Kimmel, M; Knickmeyer, R; Lun, K; Meltzer-Brody, S; Plantinga, A; Rackers, H; Wu, M; Xia, K | 1 |
| Butler, MI; Clarke, G; Cryan, JF; Dinan, TG; Long-Smith, C; Moloney, GM; Morkl, S; O'Mahony, SM | 1 |
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| Adams, RJ; Cohen, RL; Drewes, JL; Freeman, ZT; Graham, DR; Hutchinson, EK; Pate, KM; Queen, SE | 1 |
| Affatato, R; De Giorgio, D; Fracasso, C; Fumagalli, F; Garattini, S; Gobbi, M; Latini, R; Lucchetti, J; Magliocca, A; Motta, F; Novelli, D; Olivari, D; Passoni, A; Perego, C; Ristagno, G; Staszewsky, L | 1 |
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| Bugiani, M; Dijkhuis, A; Duitman, JW; Geeraerts, Z; Guo, L; Lutter, R; Nossent, EJ; Roos, E; Schurink, B; van der Valk, P; van Vught, L; Vaz, FM; Vlaar, AP; Yeh, SR | 1 |
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| Chang, Y; Han, P; Jia, C; Li, S; Wang, X; Wang, Y; Wei, W; Yang, X; Zhang, B; Zhao, Y | 1 |
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| Ashrafian, H; Darzi, A; Holmes, E; Lewis, MR; Penney, N; Purkayastha, S; Whiley, L; Yeung, KTD | 1 |
| Bottino-Rojas, V; Carballar-Lejarazú, R; Feng, X; Ferreira-Almeida, I; Gantz, V; James, AA; Kelsey, A; Nunes, RD; Oliveira, PL; Pham, TB | 1 |
| Anesi, A; Aouizerate, B; Aubert, A; Beau, C; Capuron, L; Cussotto, S; Delgado, I; Dexpert, S; Forestier, D; Ledaguenel, P; Magne, E; Mattivi, F | 1 |
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| Liu, A; Miller, A; Patel, VD; Shamsi, SA | 1 |
| Di Tommaso, M; Parenti, A; Seravalli, V; Silvano, A; Strambi, N; Tofani, L; Vallario, A | 1 |
| Chang, Q; Jiang, N; Li, CC; Liu, XM; Pan, RL; Xu, CX; Ye, F | 1 |
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| Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J | 1 |
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| Azimnasab-Sorkhabi, P; Kfoury Junior, JR; Massoco, CO; Soltani-Asl, M; Yoshinaga, TT; Zaidan Dagli, ML | 1 |
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| Campi-Azevedo, AC; Candiani, TMS; Cassiano, LMG; Coimbra, RS; de Oliveira, DB; Kohlhoff, M; Kroon, EG; Martins-Filho, OA | 1 |
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| Akan, S; Biçer, C; Erten, Ş; Serdar, MA; Yurt, EF | 1 |
| Allen-Davidian, Y; Bracken, SG; Brew, BJ; Byrne, A; Chow, S; Cysique, LA; Darley, DR; Dehhaghi, M; Dore, GJ; Guillemin, GJ; Heng, B; Jakabek, D; Kelleher, A; Matthews, GV; Phetsouphanh, C; Staats Pires, A | 1 |
| Krčmová, LK; Mrštná, K; Švec, F | 1 |
| Huang, S; Li, L; Shang, D; Wang, Z; Wen, Y | 1 |
| Du, W; Geng, L; Gong, S; Huang, L; Liang, X; Pan, W; Xiang, L; Xie, Y; Xu, W; Yang, F; Zheng, F | 1 |
| De Plaen, E; Frédérick, R; Holfelder, P; Klaessens, S; Lamy, J; Naulaerts, S; Opitz, CA; Pilotte, L; Sers, C; Solvay, M; Spillier, Q; Stroobant, V; Van den Eynde, BJ; Zhu, J | 1 |
| Gezer, U; Hakan, MT; Horozoglu, C; Kulle, CB; Özgür, E; Yaylim, I; Yörüker, EE; Zor, DS | 1 |
| Bao, Z; Chu, Q; Gu, X; Li, G; Li, L; Lu, J; Shi, Q; Su, Y; Xue, C; Yuan, X; Zheng, Q | 1 |
| Chen, J; Fang, X; Ling, Y; Liu, S; Su, KP; Tang, W; Wang, G; Wang, Y; Yang, Y; Zhang, C; Zhang, X; Zhou, C | 1 |
| Chenaux-Repond, N; Dorochow, E; Geisslinger, G; Gurke, R; Hahnefeld, L; Klein, S; Kolbinger, A; Kraus, N; Ortiz, C; Pierre, S; Scholich, K; Trebicka, J; Welsch, C | 1 |
| Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M | 1 |
| Chen, Z; Cheng, J; Dai, C; Deng, Y; Fu, Y; Li, B; Li, H; Shen, J; Shi, D; Zhao, L; Zhao, W | 1 |
| Beedu, SR; Chintaluri, S; Jaggaiahgari, S; Jakkampudi, A; Koutarapu, C; Naik, P; Patil, A; Prasanna, A; Reddy, DN; Sarkar, P; Sarkar, S; Talukdar, R; Unnisa, M | 1 |
| Churchman, M; Dey, P; Dong, B; Edge, S; Hsiao, HH; Ibrahimi, S; Isenhart, E; Kalinski, P; Kolesar, JM; Liu, S; McDonald, PH; Monjazeb, AM; Mukherjee, S; Murphy, WJ; Owen, DH; Rosario, SR; Siegel, EM; Spakowicz, DJ; Tabung, FK; Vadehra, D; Wang, J; Yendamuri, S; Zhang, Y | 1 |
| Chabat-Courrède, C; Ducroq, S; Duplus, E; Grange-Messent, V; L'honoré, A; Mhaouty-Kodja, S; Nemazanyy, I; Penalva-Mousset, L; Petropoulos, I; Trivelloni, F | 1 |
| Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y | 1 |
| Chai, X; Chen, S; Li, L; Liu, YX; Sun, P; Wang, M; Zhao, S; Zheng, W; Zhu, X | 1 |
| Abusoglu, S; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Unlu, A | 1 |
| Bruckner, T; Deisenhammer, EA; Egeter, J; Galffy, M; Giesinger, JM; Gostner, JM; Holzner, B; Hüfner, K; Lehmann, J; Nelles, P; Oberhammer, M; Rockenschaub, J; Sacher, M; Sperner-Unterweger, B; Tymoszuk, P; Vedova, S | 1 |
| Cheng, J; Jiao, L; Nie, D; Song, J; Wang, CY; Wang, DW; Wang, F; Wang, Y; Wang, Z; Wen, Z; Wu, J; Yu, K; Yu, Q; Zhang, S; Zhao, C; Zhou, L | 1 |
| Duan, X; Gou, M; Li, Q; Luan, Y; Pang, Y; Su, P; Wang, Y; Zhang, W | 1 |
| Appelman, B; Brinkman, P; Bugiani, M; Dekker, T; Dijkhuis, A; Duitman, JW; Guo, L; Houtkooper, RH; Lavell, HAA; Lutter, R; Mooij-Kalverda, K; Sikkens, JJ; Smids, BS; van Vugt, M; van Weeghel, M; Vaz, FM; Wüst, RCI | 1 |
| Ballesteros, J; Duque, G; Rivas, D | 1 |
| Hemmings, SMJ; Malan-Muller, S; Pretorius, E; Rust, C; Seedat, S; Tonge, D; van den Heuvel, LL | 1 |
| Akdoğan, N; Balci, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, CC; Serdar, MA | 1 |
| Deuschle, M; Fornal, E; Gilles, M; Kozub, A; Lamadé, EK; Marszalek-Grabska, M; Pedraz-Petrozzi, B; Stachniuk, A; Szalaj, K; Trzpil, A; Turski, WA | 1 |
| Abed, AK; Al-Hakeim, HK; Almulla, AF; Maes, M; Rouf Moustafa, S | 1 |
| Liu, Z; Mu, C; Zhu, W | 1 |
| Abraham, I; Chung, SW; Kim, HJ; Moon, JH | 1 |
| Boyer, TG; Bulun, SE; Chakravarti, D; Coon, JS; Dai, Y; Dotts, AJ; Huang, Y; Iizuka, T; Liu, S; Saini, P; Sotos, O; Wei, H; Wu, O; Yin, P; Zuberi, A | 1 |
| Bernard, JJ; Diedrich, JD; Ensink, E; Gonzalez-Pons, R; Liby, KT; Lunt, SY; Medeiros, HCD; Wellberg, EA | 1 |
| Bibb, JA; Chakraborti, A; Funakoshi, H; Kanai, M; Kawahara, Y; Kuroiwa, M; Murakami, Y; Nishi, A; Ohnishi, YN; Shuto, T; Sin, R; Sotogaku, N; Sugiyama, K | 1 |
| Niklas, K; Rutkowski, R; Samborski, W; Sikorska, D; Witoszyńska-Sobkowiak, J; Żychowska, I | 1 |
| Hong, J; Liao, G; Liu, Q; Liu, X; Lu, X; Shi, Y; Tang, H; Zhang, J | 1 |
| Bechmann, N; Fröbel, D; Langner, M; Peitzsch, M; Stanke, D; Žygienė, G | 1 |
| Guo, S; Han, M; Hui, Y; Ning, X; Qin, Y; Sun, S; Wang, A; Wang, Y; Xing, Y; Yu, Z; Yuan, J; Zhang, Y; Zhao, J; Zhao, Y | 1 |
| Chan, A; Eliassen, AH; Hu, FB; Hu, Y; Huttenhower, C; Ivey, KL; Lee, KH; Li, J; Li, Y; Qi, Q; Rimm, EB; Sun, Q; Wang, B; Zhu, L | 1 |
| Belin de Chantemèle, E; Bensreti, H; Elengickal, A; Hamrick, MW; McGee-Lawrence, ME; Sultana, S | 1 |
| Bessede, A; Cabart, M; Chomy, F; Cousin, S; Guegan, JP; Italiano, A; Lara, O; Le Moulec, S; Nafia, I; Odin, O; Peyraud, F; Rey, C | 1 |
| Antosiewicz, J; Babińska, A; Bidzan-Bluma, I; Jaworska, J; Juhas, U; Kortas, JA; Lombardi, G; Micielska, K; Rodziewicz-Flis, E; Ziemann, E; Żychowska, M | 1 |
| Bjørke-Monsen, AL; Ebbing, C; Sakkestad, ST; Ueland, PM; Ulvik, A; Varsi, K | 1 |
| Betancur, C; Callebert, J; Gautron, S; Gruszczynski, C; Guiard, BP; Launay, JM; Louis, F; Manta, S; Orrico-Sanchez, A; Paccard, A; Vialou, V | 1 |
| Kim, WJ; Nah, Y; Park, J | 1 |
| Ang, K; Ching, J; Gurung, RL; Kestenbaum, BR; Kovalik, JP; Lee, J; Lee, LS; Lim, SC; Liu, JJ; Liu, S; M, Y; Shao, YM; Sharma, K; Subramaniam, T; Sum, CF; Wee, HN; Zheng, H | 1 |
| Aprile, S; Del Grosso, E; Di Martino, RMC; Fallarini, S; Rezzi, SJ; Villani, S | 1 |
| Berkecz, R; Domoki, F; Körmöczi, T; Kovács, V; Remzső, G; Tóth-Szűki, V; Vécsei, L | 1 |
| Al-Hakeim, HK; Jasim, ZA; Stanek, A; Zolghadri, S | 1 |
| Kolks, N; Neumaier, B; Neumaier, F; Zlatopolskiy, BD | 1 |
| Berger, F; Duchesne Blanes, IL; Fulzele, S; Gupta, SK; Isales, C; Vyavahare, S | 1 |
| de Vries, BEK; de Vries, IEJ; Kooij, JJS; Nutma, I; Rus, CP | 1 |
| Bours, MJL; Breukink, SO; Eussen, SJPM; Gsur, A; Holthuijsen, DDB; Janssen-Heijnen, MLG; Keulen, ETP; Kok, DE; Ueland, PM; Ulvik, A; van Roekel, EH; Weijenberg, MP | 1 |
| Mangoni, AA; Zinellu, A | 1 |
| Bader, B; Batra, AS; Baumann, D; Carretero, R; Cichon, F; Elmadany, N; Gorjánácz, M; Gutcher, I; Hartung, IV; Irlbacher, H; Kober, C; Kreft, B; Leder, G; Lefranc, J; Lesche, R; Oezcan-Wahlbrink, M; Oezen, I; Offringa, R; Olesch, C; Opitz, CA; Platten, M; Prinz, F; Roehn, U; Roese, L; Roewe, J; Roider, HG; Sadik, A; Sahm, K; Schmees, N; Stoeckigt, D; Weinmann, H | 1 |
| Conacci-Sorrell, M; DeBerardinis, RJ; Gao, B; Mendelson, CR; Minna, JD; Nawas, AF; Solmonson, A | 1 |
| Duarte-Guterman, P; Eid, RS; Galea, LAM; Lamers, Y; Lieblich, SE; Richard, JE | 1 |
| Jędruchniewicz, K; Sadok, I | 1 |
| Gan, H; Guo, B; Liao, Y; Lin, R; Liu, M; Lyu, J; Sun, B; Xue, M; Zhang, T; Zheng, P | 1 |
| Sordillo, LA; Sordillo, PP | 1 |
| Goldman, S; Henrottin, J; Laurent, S; Lemaire, C; Luxen, A; Plenevaux, A; Sapunaric, F; Van den Eynde, B; Zervosen, A | 1 |
283 review(s) available for tryptophan and kynurenine
| Article | Year |
|---|---|
The functions and regulation of tryptophan pyrrolase.
Topics: Allosteric Regulation; Aminolevulinic Acid; Animals; Dactinomycin; Feedback; Gluconeogenesis; Heme; Kinetics; Kynurenine; Liver; NAD; NADP; Rats; Tryptophan; Tryptophan Oxygenase | 1977 |
Metabolism of indole amines in depression.
Topics: Animals; Brain; Depression; Fatty Acids, Nonesterified; Female; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Kynurenine; Male; Monoamine Oxidase Inhibitors; Rats; Serotonin; Tryptamines; Tryptophan | 1976 |
Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Autoimmune Diseases; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Inducers; Interferon-gamma; Interferons; Interleukin-2; Kynurenine; Male; Neoplasms; Niacin; Serotonin; Tryptophan; Tryptophan Oxygenase | 1991 |
Tryptophan and related alkaloids.
Topics: Alkaloids; Indoles; Kynurenine; Molecular Structure; Oxidation-Reduction; Oxygen; Photochemistry; Tryptophan | 1991 |
Tryptophan nutrition and metabolism: an overview.
Topics: Animals; Behavior; Behavior, Animal; Brain; Dietary Proteins; Humans; Kynurenine; Niacin; Nutritional Requirements; Oxidation-Reduction; Protein Biosynthesis; Rats; Serotonin; Tryptophan | 1991 |
Comparison of tryptophan metabolism in vivo and in isolated hepatocytes from vitamin B6 deficient mice.
Topics: Adrenalectomy; Adult; Animals; Cells, Cultured; Child; Female; Humans; Hydrolases; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Middle Aged; Mixed Function Oxygenases; NAD; Ovariectomy; Oxidation-Reduction; Rats; Tryptophan; Tryptophan Oxygenase; Vitamin B 6 Deficiency | 1991 |
Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism.
Topics: Animals; Chlamydia trachomatis; Enzyme Induction; Fibroblasts; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Pteridines; Toxoplasma; Tryptophan; Tryptophan Oxygenase | 1991 |
Kynurenine metabolites of tryptophan: implications for neurologic diseases.
Topics: Animals; Brain; Humans; Kynurenine; Nervous System Diseases; Tryptophan | 1990 |
Quantitative aspects of tryptophan metabolism in humans and other species: a review.
Topics: Age Factors; Amides; Animals; Carbon Isotopes; Cats; Dogs; Female; Glucuronates; Glycine; Hippurates; Humans; Hydroxyindoleacetic Acid; Indican; Kynurenic Acid; Kynurenine; Lysine; Male; Mice; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Pyridones; Pyridoxine; Rats; Serotonin; Sex Factors; Species Specificity; Swine; Time Factors; Tryptophan; Xanthurenates | 1971 |
Excretion of tryptophan metabolites as affected by pregnancy, contraceptive steroids, and steroid hormones.
Topics: Androsterone; Animals; Contraceptives, Oral; Enzyme Induction; Estradiol; Female; Humans; Hydrocortisone; Kynurenine; Liver; Male; Megestrol; NAD; Niacinamide; ortho-Aminobenzoates; Pregnancy; Pyridoxine; Rats; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1971 |
The antivitamin B 6 effect of penicillamine: clinical and immunological implications.
Topics: Antibody Formation; Arthritis, Rheumatoid; Drug Antagonism; Drug Interactions; Humans; Immunosuppression Therapy; Kynurenine; Penicillamine; Precipitin Tests; Pyridoxine; Rheumatoid Factor; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
[Chief clinical syndromes in children with tryptophan metabolism disorders (literature survey)].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Carboxy-Lyases; Child; Child, Preschool; Diabetes Mellitus; Glutamates; Hartnup Disease; Humans; Hydrolases; Intestinal Absorption; Intestinal Mucosa; Kidney; Kynurenine; Liver; Metabolic Diseases; Neurologic Manifestations; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxal; Pyridoxine; Skin Manifestations; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
Kynurenines as probable participants of depression.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Behavior; Blood Pressure; Body Temperature; Depression; Dopamine; Drug Interactions; Drug Synergism; Humans; Kynurenine; Mice; Motor Activity; Norepinephrine; ortho-Aminobenzoates; Rats; Serotonin; Serotonin Antagonists; Species Specificity; Sympathetic Nervous System; Tryptamines; Tryptophan | 1973 |
The role of amines in the etiology of schizophrenia.
Topics: Adrenochrome; Amines; Amphetamine; Brain Chemistry; Dopamine; Epinephrine; Humans; Indoles; Kynurenine; Mescaline; Monoamine Oxidase Inhibitors; Norepinephrine; Phenethylamines; Phenylalanine; Psychoses, Substance-Induced; Schizophrenia; Serotonin; Tryptamines; Tryptophan | 1968 |
[On the biochemistry of ommochromes. Breakdown, occurrence, biosynthesis and physiologic correlates].
Topics: Animals; Eye; Insecta; Kynurenine; Metamorphosis, Biological; Pigments, Biological; Tryptophan; Tryptophan Oxygenase | 1967 |
5-hydroxykynuramine (mausamine).
Topics: Amines; Animals; Chemical Phenomena; Chemistry; Chromatography; Fluorometry; Humans; Kynurenine; Monoamine Oxidase; Tryptophan | 1968 |
Xanthurenic acid and xanthurenic acid-8-methyl ether.
Topics: Animals; Blood Glucose; Ethers; Insulin; Kynurenine; Pyridoxal Phosphate; Time Factors; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1968 |
Factors which alter the metabolism of tryptophan.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Contraceptives, Oral; Female; Humans; Kynurenine; Nicotinic Acids; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1968 |
Tryptophan pyrrolase--a biochemical factor in depressive illness?
Topics: Animals; Brain; Cats; Depression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Pituitary-Adrenal System; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1969 |
The role of urinary tryptophan metabolites in the etiology of bladder cancer.
Topics: Alcohols; Amino Acids; Animals; Carcinogens; Ethers; Female; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Mice; Mucous Membrane; ortho-Aminobenzoates; Phenylbutyrates; Quinolines; Rats; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xanthurenates | 1971 |
L-kynurenine: its synthesis and possible regulatory function in brain.
Topics: Animals; Arylformamidase; Brain; Decarboxylation; Humans; Hydroxyindoleacetic Acid; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Oxygenases; Serotonin; Tryptophan; Tryptophan Oxygenase | 1980 |
Photochemistry of proteins: a review.
Topics: Animals; Crystallins; Free Radicals; In Vitro Techniques; Infrared Rays; Kynurenine; Lens, Crystalline; Light; Photochemistry; Tryptophan; Tyrosine; Ultraviolet Rays | 1984 |
Clinical chemistry of vitamin B6.
Topics: Animals; Biological Assay; Biological Availability; Biological Transport; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Humans; Infections; Intestinal Absorption; Kynurenine; Lactation; Liver; Models, Biological; Nutritional Requirements; Oxidation-Reduction; Phosphorylation; Pregnancy; Pyridoxal; Pyridoxal Phosphate; Pyridoxic Acid; Pyridoxine; Radioimmunoassay; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1983 |
Endogenous kynurenine derivatives and pain.
Topics: Analgesia; Animals; Brain; Humans; Kynurenine; Models, Neurological; Neurons; Nociceptors; Pain; Serotonin; Spinal Cord; Tryptophan | 1996 |
[Microanalysis of tryptophan metabolites].
Topics: 3-Hydroxyanthranilic Acid; Animals; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Mice; Microchemistry; Tryptophan; Ultraviolet Rays; Urinary Bladder Neoplasms | 1997 |
Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Hydrolases; Indoles; Kynurenine; Receptors, N-Methyl-D-Aspartate; Tryptophan | 1999 |
Alpha[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism.
Topics: Brain; Carbon Radioisotopes; Humans; Kynurenine; Serotonin; Tomography, Emission-Computed; Tryptophan | 2000 |
Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway.
Topics: Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxidation-Reduction; Tryptophan; Tryptophan Oxygenase | 1999 |
[Kinurenin degradation pathway in eye: present state of knowledge].
Topics: Eye; Kynurenine; Tryptophan | 1999 |
[Kynurenic pathway in health and disease].
Topics: Animals; Brain; Brain Diseases; Humans; Kidney Diseases; Kynurenine; Liver Diseases; Nervous System; Tryptophan | 2000 |
Endogenous neurotoxins from tryptophan.
Topics: Animals; Humans; Kynurenine; Nervous System Diseases; Neurotoxins; Quinolinic Acid; Tryptophan | 2001 |
[Enzymes of the kynurenine pathway].
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Amidohydrolases; Antidepressive Agents, Second-Generation; Biomarkers; Dioxygenases; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Oxygenases; Pentosyltransferases; Picolinic Acids; Transaminases; Tryptophan; Tryptophan Oxygenase | 2001 |
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2002 |
Endogenous kynurenines as targets for drug discovery and development.
Topics: Animals; Drug Delivery Systems; Drug Design; Humans; Kynurenic Acid; Kynurenine; Signal Transduction; Technology, Pharmaceutical; Tryptophan | 2002 |
Tolerance, DCs and tryptophan: much ado about IDO.
Topics: Animals; Dendritic Cells; Female; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Pregnancy; Signal Transduction; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan and the immune response.
Topics: Animals; Dendritic Cells; Dioxygenases; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxygenases; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; Kynurenine; Quinolinic Acid; Tryptophan | 2003 |
ASPECTS OF DISORDERS OF THE KYNURENINE PATHWAY OF TRYPTOPHAN METABOLISM IN MAN.
Topics: Amino Acids; Diabetes Mellitus; Fluids and Secretions; Geriatrics; Hodgkin Disease; Humans; Kidney Calculi; Kynurenine; Leukemia; Liver Diseases; Lymphoma; Metabolic Diseases; Pregnancy; Schizophrenia; Seizures; Tryptophan; Urine; Urologic Diseases; Vitamin B 6 Deficiency; Xanthurenates | 1964 |
The kynurenine pathway of tryptophan degradation as a drug target.
Topics: Animals; Humans; Kynurenine; Metabolism; Tryptophan | 2004 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan | 2004 |
Serotonin in autism and pediatric epilepsies.
Topics: Animals; Autistic Disorder; Brain; Child; Electroencephalography; Epilepsy; Humans; Kynurenine; Magnetic Resonance Imaging; Mice; Positron-Emission Tomography; Serotonin; Tryptophan | 2004 |
[Metabolism of tryptophan via the kynurenine pathway in saliva].
Topics: Humans; Kynurenine; Periodontal Diseases; Saliva; Tryptophan | 2005 |
Monitoring tryptophan metabolism in chronic immune activation.
Topics: Autoimmune Diseases; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infections; Kynurenine; Neoplasms; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase | 2006 |
Glial metabolites of tryptophan and excitotoxicity: coming unglued.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Humans; Kainic Acid; Kynurenine; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuroglia; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2006 |
Tryptophan metabolism in the central nervous system: medical implications.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Central Nervous System; Humans; Kynurenine; Tryptamines; Tryptophan | 2006 |
Tryptophan catabolism in IDO+ plasmacytoid dendritic cells.
Topics: Animals; Apoptosis; Dendritic Cells; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; T-Lymphocytes; Tryptophan | 2007 |
Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines.
Topics: Animals; Anti-Infective Agents; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2007 |
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Cyclic ADP-Ribose; DNA Damage; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Mice; NAD; Neoplasms; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sirtuins; Tryptophan | 2007 |
IDO expression in the brain: a double-edged sword.
Topics: Animals; Brain; Candidiasis; Cytomegalovirus Infections; Encephalomyelitis, Autoimmune, Experimental; HIV Infections; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Multiple Sclerosis; Neurons; Tryptophan | 2007 |
Interferon-induced depression: mechanisms and management.
Topics: Cyclooxygenase 2; Depressive Disorder; Female; Humans; Hypothalamo-Hypophyseal System; Interferon-alpha; Kynurenine; Male; Nervous System Diseases; Tryptophan | 2007 |
Tumor immune escape mediated by indoleamine 2,3-dioxygenase.
Topics: Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; T-Lymphocytes; Tryptophan; Tumor Escape | 2007 |
Tryptophan, adenosine, neurodegeneration and neuroprotection.
Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Tryptophan | 2007 |
Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging.
Topics: Aging; Animals; Cognition Disorders; Cytokines; Depressive Disorder, Major; Hormones; Humans; Kynurenine; Models, Biological; Nitric Oxide Synthase Type II; Tryptophan | 2007 |
Indoleamine 2,3-dioxygenase in transplantation.
Topics: Abatacept; Animals; Antioxidants; Dendritic Cells; Humans; Immune Tolerance; Immunoconjugates; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphocyte Subsets; Macrophages; T-Lymphocytes, Regulatory; Transplantation Immunology; Transplantation Tolerance; Tryptophan | 2008 |
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway.
Topics: Animals; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Liver; Male; Mice; Reproduction; Substrate Specificity; Tryptophan; Tryptophan Oxygenase | 2009 |
Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species.
Topics: Animals; Antioxidants; Carcinogens; Humans; Kynuramine; Kynurenine; Melatonin; Mutagens; Nitric Oxide Donors; Nitrogen Dioxide; Nitroso Compounds; Oxidation-Reduction; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Serotonin; Stress, Physiological; Tryptophan | 2008 |
IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi.
Topics: Animals; Cytokines; Fungi; Humans; Immune Reconstitution Inflammatory Syndrome; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-17; Interleukin-23; Kynurenine; Mycoses; T-Lymphocytes, Regulatory; Tryptophan | 2008 |
A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Cytokines; Depression; Depressive Disorder, Major; Humans; Hypothalamo-Hypophyseal System; Kynurenine; Metabolic Networks and Pathways; Models, Biological; Pituitary-Adrenal System; Serotonin; Stress, Psychological; Tryptophan | 2008 |
Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease.
Topics: Animals; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Isoenzymes; Kynurenine; Models, Molecular; Molecular Structure; Neoplasms; Protein Conformation; Substrate Specificity; Tryptophan | 2009 |
IDO: a double-edged sword for T(H)1/T(H)2 regulation.
Topics: Animals; Cell Differentiation; Dendritic Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Th1 Cells; Th2 Cells; Toll-Like Receptors; Tryptophan; Up-Regulation | 2008 |
Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.
Topics: Animals; Fungi; Host-Pathogen Interactions; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mycoses; Tryptophan | 2009 |
Neuropsychiatric disorders related to interferon and interleukins treatment.
Topics: Animals; Brain; Brain Diseases, Metabolic; Cytokines; Encephalitis; Humans; Interferons; Interleukins; Kynurenine; Mental Disorders; Tryptophan | 2009 |
New promises for manipulation of kynurenine pathway in cancer and neurological diseases.
Topics: Animals; Drug Delivery Systems; Drug Discovery; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Schizophrenia; Tryptophan | 2009 |
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kynurenine; Mice; Mutation; Peptides; Quinolinic Acid; Rats; Receptors, Glutamate; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2010 |
Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function.
Topics: Animals; Bacteria; Digestive System Physiological Phenomena; Gastrointestinal Diseases; Humans; Intestines; Kynurenine; Nutritional Physiological Phenomena; Serotonin; Tryptophan | 2009 |
Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds.
Topics: Animals; Autoimmunity; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Patents as Topic; Stereoisomerism; T-Lymphocytes; Tryptophan | 2010 |
Kynurenines, neurodegeneration and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Structure; Nerve Degeneration; Plaque, Amyloid; Quinolinic Acid; Tryptophan | 2010 |
Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism.
Topics: Aging; Animals; Endocrine System Diseases; Humans; Kynurenine; Metabolic Syndrome; Nervous System Diseases; Tryptophan | 2010 |
Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.
Topics: Adrenal Cortex Hormones; Animals; Biosynthetic Pathways; Cytokines; Depressive Disorder, Major; Environment; Genetic Predisposition to Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Serotonin; Stress, Psychological; Tryptophan; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
Possible roles of excess tryptophan metabolites in cancer.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Damage; Dogs; Humans; Kynurenine; Liver Neoplasms; Male; Mice; Mutagens; Rats; Serotonin; Tryptophan; Urinary Bladder Neoplasms | 2011 |
Tryptophan metabolism, from nutrition to potential therapeutic applications.
Topics: Animals; Drug Therapy; Humans; Infections; Inflammation; Kynurenine; Nutritional Status; Tryptophan | 2011 |
Kynurenine metabolism in health and disease.
Topics: Animals; Humans; Immune System; Immunity; Kynurenine; Tryptophan | 2011 |
Mechanism of acute tryptophan depletion: is it only serotonin?
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cerebrovascular Disorders; Cognition; Eating; Humans; Kynurenine; Mental Disorders; Models, Biological; Serotonin; Tryptophan | 2011 |
Structure and reaction mechanism in the heme dioxygenases.
Topics: Animals; Biocatalysis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Models, Molecular; Molecular Structure; Protein Structure, Tertiary; Tryptophan; Tryptophan Oxygenase | 2011 |
Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects.
Topics: Animals; Anti-Inflammatory Agents; Antipsychotic Agents; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Mice; Molecular Targeted Therapy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Tryptophan | 2011 |
Biochemical properties of indoleamine 2,3-dioxygenase: from structure to optimized design of inhibitors.
Topics: Animals; Crystallography, X-Ray; Enzyme Inhibitors; Gene Expression; Heme; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Models, Molecular; Protein Conformation; Tryptophan | 2011 |
The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?
Topics: Animals; Humans; Kynurenine; Migraine Disorders; Pain; Pain Perception; Signal Transduction; Tryptophan | 2011 |
Altered tryptophan metabolism in Parkinson's disease: a possible novel therapeutic approach.
Topics: Antiparkinson Agents; Humans; Kynurenine; Levodopa; Parkinson Disease; Tryptophan | 2011 |
α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.
Topics: Biomarkers; Brain; Epilepsy; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Positron-Emission Tomography; Serotonin; Tryptophan | 2011 |
The role of the kynurenine metabolism in major depression.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Tryptophan | 2012 |
Immunological treatment options for schizophrenia.
Topics: Animals; Antipsychotic Agents; Astrocytes; Cyclooxygenase 2 Inhibitors; Humans; Kynurenine; Microglia; Schizophrenia; Tryptophan | 2012 |
Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: medicinal chemistry aspects.
Topics: Animals; Chemistry, Pharmaceutical; Humans; Kynurenine; Mitochondria; Neurodegenerative Diseases; Tryptophan | 2012 |
Inflammation in schizophrenia.
Topics: Antipsychotic Agents; Brain; Humans; Inflammation; Kynurenine; Macrophages; Microglia; Monocytes; Schizophrenia; Tryptophan | 2012 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2012 |
Emerging concepts on inhibitors of indoleamine 2,3-dioxygenase in rheumatic diseases.
Topics: Animals; Arthritis, Rheumatoid; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lupus Erythematosus, Systemic; Rheumatic Diseases; Scleroderma, Systemic; Sjogren's Syndrome; Tryptophan | 2012 |
Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.
Topics: Animals; Autoimmunity; Cell Lineage; Dendritic Cells; Gene Expression Regulation; Humans; Immune Tolerance; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Neoplasms; Signal Transduction; Tryptophan | 2012 |
Host indoleamine 2,3-dioxygenase: contribution to systemic acquired tumor tolerance.
Topics: Animals; Antineoplastic Agents; Dendritic Cells; Enzyme Inhibitors; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Mice; Neoplasms; Signal Transduction; T-Lymphocytes, Regulatory; Tryptophan | 2012 |
An expanding range of targets for kynurenine metabolites of tryptophan.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Oxidation-Reduction; Quinolinic Acid; Tryptophan | 2013 |
Reactive oxygen and oxidative stress: N-formyl kynurenine in photosystem II and non-photosynthetic proteins.
Topics: Animals; Biomarkers; Kynurenine; Models, Animal; Models, Molecular; Oxidative Stress; Photosystem II Protein Complex; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Subunits; Reactive Oxygen Species; Ribulose-Bisphosphate Carboxylase; Tryptophan; Ultraviolet Rays | 2012 |
Kynurenines in the CNS: recent advances and new questions.
Topics: Animals; Autoimmune Diseases; Central Nervous System Diseases; Drug Design; Drug Evaluation, Preclinical; Humans; Immune Tolerance; Kynurenine; Migraine Disorders; Neurodegenerative Diseases; Pain; Tryptophan | 2013 |
Kynurenines in cognitive functions: their possible role in depression.
Topics: Cognition; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Signal Transduction; Tryptophan | 2012 |
[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Topics: Humans; Hydroxyindoleacetic Acid; Kynurenine; Mental Disorders; Psychotic Disorders; Tryptophan; Xanthurenates | 2013 |
Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways.
Topics: Biomarkers; Humans; Insulin Resistance; Kynurenine; Metabolic Networks and Pathways; NAD; Tryptophan | 2013 |
[Immune modulation by tryptophan metabolism: relevance for autoimmune and tumor diseases].
Topics: Animals; Autoimmune Diseases; Brain; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Immune Tolerance; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Neoplasms; Serotonin; Treatment Outcome; Tryptophan | 2013 |
Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing.
Topics: Cystic Fibrosis; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydrolases; Immune Evasion; Kynurenic Acid; Kynurenine; Neutrophils; Oxygen Consumption; Pseudomonas aeruginosa; Pseudomonas Infections; Reactive Oxygen Species; Tryptophan | 2014 |
The common inflammatory etiology of depression and cognitive impairment: a therapeutic target.
Topics: Animals; Cognition Disorders; Depression; Humans; Inflammation; Kynurenine; Signal Transduction; Tryptophan | 2014 |
The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.
Topics: Acute Disease; Brain Ischemia; Chronic Disease; Humans; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2016 |
Targeting key dioxygenases in tryptophan-kynurenine metabolism for immunomodulation and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Catalytic Domain; Dioxygenases; Drug Discovery; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Structure-Activity Relationship; Tryptophan; Tryptophan Oxygenase | 2015 |
The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field.
Topics: Animals; Atherosclerosis; Humans; Kynurenine; Models, Cardiovascular; Plaque, Atherosclerotic; Signal Transduction; Tryptophan | 2015 |
The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment.
Topics: Animals; Cell Proliferation; Dendritic Cells; Humans; Immunity, Cellular; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neoplasms; T-Lymphocytes; Tryptophan | 2015 |
The kynurenine pathway and neurodegenerative disease.
Topics: Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Neurodegenerative Diseases; Tryptophan | 2015 |
Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation.
Topics: Adult; Aged; Animals; Cardiovascular Diseases; Female; Humans; Immune System Diseases; Inflammation; Kidney Diseases; Kynurenine; Male; Mammals; Metabolic Networks and Pathways; Middle Aged; Oxidative Stress; Rabbits; Rats; Tryptophan; Young Adult | 2015 |
[Indoleamine 2,3-dioxygenase in oncology and psychiatry].
Topics: Brain; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mental Disorders; Neoplasms; Tryptophan | 2015 |
OLD AND NEW NEUROENDOCRINE MOLECULES: SOMATOSTATIN, CYSTEAMINE, PANTETHINE AND KYNURENINE.
Topics: Animals; Cysteamine; History, 20th Century; Humans; Kynurenine; Neuroendocrinology; Neurosecretory Systems; Pantetheine; Rats; Signal Transduction; Somatostatin; Tryptophan | 2014 |
Role of indoleamine 2,3-dioxygenase in health and disease.
Topics: Animals; Bacterial Infections; Catalysis; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Models, Biological; Neoplasms; Nervous System Diseases; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Signal Transduction; Substrate Specificity; Tryptophan | 2015 |
Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.
Topics: Colon; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Signal Transduction; Tryptophan | 2016 |
Learning from other diseases: protection and pathology in chronic fungal infections.
Topics: Animals; Disease Resistance; Disease Susceptibility; Fungi; Host-Pathogen Interactions; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Metabolic Networks and Pathways; Metagenome; Metagenomics; Mycoses; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan | 2016 |
Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease.
Topics: Alzheimer Disease; Animals; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Parkinson Disease; Signal Transduction; Tryptophan | 2015 |
Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements.
Topics: Aging; Animals; Diet; Dietary Supplements; Exercise; Humans; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2017 |
Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways.
Topics: Animals; Bipolar Disorder; Humans; Kynurenine; Melatonin; Signal Transduction; Tryptophan | 2016 |
L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences.
Topics: Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Nervous System Diseases; Tryptophan | 2017 |
New insights into tryptophan and its metabolites in the regulation of bone metabolism.
Topics: Animals; Bone and Bones; Humans; Kynurenine; Melatonin; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates | 2015 |
Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions.
Topics: Animals; Humans; Immune System Diseases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mental Disorders; Metabolic Networks and Pathways; Tryptophan | 2017 |
Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases.
Topics: Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Nervous System Diseases; Tryptophan | 2017 |
Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.
Topics: Animals; Humans; Hydrolases; Kynurenine; Minerals; Signal Transduction; Transaminases; Tryptophan; Vitamins | 2016 |
Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).
Topics: Animals; Central Nervous System Neoplasms; Cognition Disorders; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Neurodegenerative Diseases; Patents as Topic; Structure-Activity Relationship; Tryptophan | 2016 |
Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Quinolinic Acid; Tryptophan | 2017 |
Kynurenines and Glutamate: Multiple Links and Therapeutic Implications.
Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenine; Tryptophan | 2016 |
The end of the road for the tryptophan depletion concept in pregnancy and infection.
Topics: Antigen-Presenting Cells; Communicable Diseases; Female; Fetus; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxidative Stress; Pregnancy; Pregnancy Complications; Protein Binding; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2016 |
Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression.
Topics: Animals; Autonomic Nervous System; Depressive Disorder, Major; Humans; Kynurenine; Stress, Psychological; Tryptophan | 2016 |
A review of the immunomodulatory role of dietary tryptophan in livestock and poultry.
Topics: Animal Feed; Animals; Dietary Supplements; Humans; Immunity, Innate; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Livestock; Lymphocytes; Melatonin; Poultry; Quinolinic Acid; Serotonin; Swine; Tryptophan | 2017 |
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases.
Topics: Aging; Animals; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus; Drug Discovery; Endothelial Cells; Enzyme Inhibitors; Humans; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Obesity; Signal Transduction; Transaminases; Tryptophan | 2017 |
Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications.
Topics: Cardiovascular Diseases; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Liver; Signal Transduction; Tryptophan | 2017 |
The Kynurenine Pathway: A Primary Resistance Mechanism in Patients with Glioblastoma.
Topics: Animals; Antineoplastic Agents; Cytokines; Drug Resistance, Neoplasm; Glioblastoma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2017 |
The interplay between metabolic remodeling and immune regulation in glioblastoma.
Topics: Glioblastoma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2017 |
Chromatographic analysis of tryptophan metabolites.
Topics: Chromatography; Humans; Kynurenine; Tryptophan | 2017 |
Phytochemical treatments target kynurenine pathway induced oxidative stress.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan | 2018 |
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
Topics: Brain; Depression; Exercise; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Inflammation; Kynurenine; Liver; Mental Disorders; Mental Health; Muscle, Skeletal; Neoplasms; Signal Transduction; Tryptophan | 2017 |
The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis.
Topics: Adaptive Immunity; Animals; Atherosclerosis; Cardiovascular Diseases; Cytokines; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2019 |
Mechanisms of poststroke fatigue.
Topics: Fatigue; Humans; Inflammation; Kynurenine; Signal Transduction; Stroke; Tryptophan | 2018 |
Inflammation-induced depression: Its pathophysiology and therapeutic implications.
Topics: Animals; Depression; Humans; Inflammation; Kynurenine; Serotonin; Tryptophan | 2017 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progression; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide Synthase; Nitrosative Stress; Oxidative Stress; Quality of Life; Quinolinic Acid; Tryptophan | 2017 |
The role of tryptophan metabolism in postpartum depression.
Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2018 |
Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects.
Topics: Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Stroke; Tryptophan | 2018 |
Current evidence linking diet to gut microbiota and brain development and function.
Topics: Animals; Biological Availability; Brain; Carbohydrate Metabolism; Diet; Fermentation; Gastrointestinal Microbiome; Gastrointestinal Tract; Host Microbial Interactions; Humans; Indoles; Kynurenine; Lipid Metabolism; Microbial Viability; Nervous System; Neurotransmitter Agents; Polyphenols; Proteins; Serotonin; Tryptophan | 2019 |
Targeting tryptophan availability to tumors: the answer to immune escape?
Topics: Albumins; Animals; Biomarkers; Fatty Acids; Humans; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Neoplasms; Tryptophan; Tumor Escape | 2018 |
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Indoles; Inflammatory Bowel Diseases; Kynurenine; Metabolic Syndrome; Obesity; Serotonin; Short Bowel Syndrome; Tryptophan | 2018 |
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan | 2018 |
Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis.
Topics: Cell Differentiation; Fibroblasts; Fibrosis; Humans; Kynurenine; Receptors, Aryl Hydrocarbon; Serotonin; Signal Transduction; Transforming Growth Factor beta; Tryptophan | 2018 |
Acute and chronic effects of exercise on the kynurenine pathway in humans - A brief review and future perspectives.
Topics: Exercise; Humans; Kynurenine; Signal Transduction; Tryptophan | 2018 |
Metabolomics in patients with psychosis: A systematic review.
Topics: 3-Hydroxybutyric Acid; Aspartic Acid; Biomarkers; Bipolar Disorder; Creatine; Female; Glutamic Acid; Glutathione; Humans; Kynurenine; Lactic Acid; Linoleic Acid; Male; Metabolome; Metabolomics; Psychotic Disorders; Schizophrenia; Serine; Tryptophan | 2018 |
[The importance of the kynurenine pathway in depressive disorders].
Topics: Antidepressive Agents; Depressive Disorder; Humans; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2018 |
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Illness Behavior; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukins; Kynurenine; Models, Neurological; Models, Psychological; Neuroglia; Peripheral Nervous System; Pituitary-Adrenal System; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Social Isolation; Stress, Psychological; Toll-Like Receptor 4; Tryptophan; Vaccines | 2018 |
Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan-Kynurenine-Aryl Hydrocarbon Axis.
Topics: Cell Line, Tumor; Computational Biology; Enzyme Inhibitors; Gene Expression Profiling; Humans; Immunomodulation; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Models, Biological; Neoplasms; Receptors, Aryl Hydrocarbon; Signal Transduction; Transcriptome; Tryptophan | 2019 |
Emerging role for kynurenines in metabolic pathologies.
Topics: Aging; Animals; Atherosclerosis; Biomarkers; Diabetes Mellitus; Homeostasis; Humans; Islets of Langerhans; Kynurenine; Metabolic Diseases; Metabolic Networks and Pathways; Obesity; Tryptophan | 2019 |
Symposium review: Immunological detection of the bovine conceptus during early pregnancy.
Topics: Animals; Cattle; Embryo, Mammalian; Endometrium; Female; Gene Expression; Gestational Age; Immune Tolerance; Interleukin-10; Interleukin-15; Kynurenine; Lymphocytes; Pregnancy; RNA, Messenger; Tryptophan | 2019 |
Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia.
Topics: Animals; Brain; Humans; Kynurenine; Phencyclidine; Schizophrenia; Signal Transduction; Tryptophan | 2019 |
RETRACTED: Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.
Topics: Diabetes, Gestational; Embryonic Development; Female; Fetal Development; Homeostasis; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Obesity, Maternal; Placenta; Pregnancy; Pregnancy Complications; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2020 |
The 'Yin' and the 'Yang' of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders.
Topics: Animals; Brain; Cytokines; Depressive Disorder, Major; Excitatory Amino Acid Agents; Humans; Hypothalamo-Hypophyseal System; Inflammation; Kynurenine; Neurodegenerative Diseases; Neuroprotection; Pituitary-Adrenal System; Tryptophan | 2019 |
The kynurenine pathway: a finger in every pie.
Topics: Aging; Animals; Energy Metabolism; Humans; Kynurenine; Mental Disorders; NAD; Neurodegenerative Diseases; Signal Transduction; Tryptophan | 2020 |
Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment.
Topics: Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasm Proteins; Neoplasms; Signal Transduction; Tryptophan | 2019 |
Hypothesis: Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Allopurinol; Animals; Enzyme Induction; Enzyme Inhibitors; Fasting; Feedback, Physiological; Gene Silencing; Glucose; Guinea Pigs; Heme; Humans; Kynurenine; Liver; Models, Biological; Molecular Targeted Therapy; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Porphyrias, Hepatic; Rodentia; Species Specificity; Tryptophan; Tryptophan Oxygenase | 2019 |
Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis.
Topics: Animals; Brain; Gastrointestinal Microbiome; Humans; Indoles; Kynurenine; Mental Disorders; Tryptophan | 2019 |
Kynurenine pathway and human systems.
Topics: Aging; Cytokines; Humans; Kynurenine; Tryptophan | 2020 |
Clinical insights into the kynurenine pathway in age-related diseases.
Topics: Aged; Aging; Animals; Biomarkers; Frailty; Humans; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2020 |
Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway.
Topics: Animals; Biomarkers; Disease Susceptibility; Gene Expression Regulation, Enzymologic; Genetic Variation; Host-Pathogen Interactions; Humans; Immunity; Immunomodulation; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2019 |
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan.
Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Humans; Inflammation; Kynurenine; Longevity; Mice; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan | 2020 |
The therapeutic potential of targeting tryptophan catabolism in cancer.
Topics: Animals; Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neoplasms; Tryptophan; Tryptophan Oxygenase | 2020 |
Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain.
Topics: Animals; Brain; Gastrointestinal Microbiome; Humans; Kynurenine; Neurotransmitter Agents; Tryptophan | 2020 |
IDO activation, inflammation and musculoskeletal disease.
Topics: Animals; Arthritis, Rheumatoid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Musculoskeletal Diseases; Osteoporosis; Rats; Tryptophan | 2020 |
Kynurenine pathway, NAD
Topics: Aging; Animals; Brain; Humans; Kynurenine; Longevity; Metabolic Networks and Pathways; Mice; Mitochondria; Mitophagy; NAD; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Tryptophan | 2020 |
An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder.
Topics: Antidepressive Agents; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 2021 |
Effects of tryptophan, serotonin, and kynurenine on ischemic heart diseases and its risk factors: a Mendelian Randomization study.
Topics: Humans; Kynurenine; Mendelian Randomization Analysis; Myocardial Ischemia; Polymorphism, Single Nucleotide; Risk Factors; Serotonin; Tryptophan | 2020 |
Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer.
Topics: Anemia; Animals; Depression; Fatigue; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neoplasms; Tryptophan | 2020 |
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain.
Topics: Brain; Central Nervous System; Exercise; Homeostasis; Humans; Immune System; Kynurenine; Metabolic Networks and Pathways; Metabolism; Muscle, Skeletal; PPAR gamma; Tryptophan | 2020 |
Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Biomarkers; Cytokines; Humans; Huntington Disease; Inflammation; Kynurenine; Neurodegenerative Diseases; Parkinson Disease; Reactive Oxygen Species; Tryptophan | 2020 |
The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Disease Management; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Humans; Kynurenine; Ligands; Metabolic Networks and Pathways; Molecular Targeted Therapy; Nervous System; Nervous System Neoplasms; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan | 2020 |
Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cancer Survivors; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Neoplasms; Tryptophan | 2020 |
The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents.
Topics: Analgesics; Animals; Chronic Pain; Depression; Headache; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Molecular Targeted Therapy; Neuralgia; Species Specificity; Tryptophan | 2020 |
Effect of immune activation on the kynurenine pathway and depression symptoms - A systematic review and meta-analysis.
Topics: Depression; Humans; Kynurenic Acid; Kynurenine; Prospective Studies; Tryptophan | 2020 |
Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?
Topics: Animals; Arginine; Arthritis, Rheumatoid; Humans; Kynurenine; Microbiota; Serotonin; Tryptophan | 2020 |
Trial watch: IDO inhibitors in cancer therapy.
Topics: Animals; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Tryptophan | 2020 |
Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia.
Topics: Antineoplastic Agents; Cell Differentiation; Dendritic Cells; Disease Progression; Gene Expression Regulation, Leukemic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Myeloid, Acute; Prognosis; Progression-Free Survival; Protein Processing, Post-Translational; Survival Rate; T-Lymphocytes, Regulatory; Tryptophan; Tumor Escape; Tumor Microenvironment; Up-Regulation | 2020 |
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis.
Topics: Aged; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2020 |
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinolinic Acid; Tryptophan | 2021 |
Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases.
Topics: Adjuvants, Immunologic; Humans; Immune System Diseases; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Tryptophan; Tumor Microenvironment | 2022 |
Gut microbiota, kynurenine pathway and mental disorders - Review.
Topics: Animals; Brain; Brain-Gut Axis; Gastrointestinal Microbiome; Humans; Kynurenine; Mental Disorders; Probiotics; Signal Transduction; Tryptophan | 2021 |
An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease.
Topics: Colitis, Ulcerative; Gastrointestinal Microbiome; Humans; Indoles; Inflammatory Bowel Diseases; Kynurenine; Serotonin; Tryptophan | 2021 |
The Uniqueness of Tryptophan in Biology: Properties, Metabolism, Interactions and Localization in Proteins.
Topics: Animals; Codon; Dipeptides; Humans; Hydrophobic and Hydrophilic Interactions; Indolequinones; Indoles; Kynurenine; Protein Biosynthesis; Protein Interaction Domains and Motifs; Proteins; Serotonin; Structure-Activity Relationship; Thermodynamics; Tryptophan | 2020 |
Tryptophan Metabolism as a Pharmacological Target.
Topics: Humans; Kynurenine; Tryptophan; Tryptophan Oxygenase | 2021 |
Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway.
Topics: Animals; Biomarkers; Brain; Gastrointestinal Microbiome; Humans; Kynurenine; Neurodegenerative Diseases; Tryptophan | 2020 |
Role of tryptophan metabolism in cancers and therapeutic implications.
Topics: Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasm Proteins; Neoplasms; Tryptophan; Tryptophan Oxygenase; Tumor Microenvironment | 2021 |
Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis.
Topics: Humans; Kynurenine; Prebiotics; Probiotics; Tryptophan | 2021 |
A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes.
Topics: Animals; Carbazoles; Chloracne; Dermatitis, Atopic; Humans; Hyperpigmentation; Kynurenic Acid; Kynurenine; Ligands; Melanoma; Mice; Microbiota; Oxidative Stress; Psoriasis; Receptors, Aryl Hydrocarbon; Skin; Skin Diseases; Skin Neoplasms; Skin Physiological Phenomena; Tryptophan; Vitiligo | 2021 |
Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis.
Topics: Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
Topics: Animals; Cognition; COVID-19; Humans; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Neuroprotective Agents; Signal Transduction; Sulfonamides; Thiazoles; Tryptophan | 2021 |
Kynurenine induces an age-related phenotype in bone marrow stromal cells.
Topics: Autophagy; Bone Marrow Cells; Cellular Senescence; Humans; Kynurenine; Musculoskeletal Physiological Phenomena; Osteogenesis; Osteoporosis; Signal Transduction; Stromal Cells; Tryptophan | 2021 |
Latest developments in tryptophan metabolism: Understanding its role in B cell immunity.
Topics: B-Lymphocytes; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2021 |
Tryptophan Metabolism via Kynurenine Pathway: Role in Solid Organ Transplantation.
Topics: Animals; Biomarkers; Graft Rejection; Graft Survival; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Organ Transplantation; Reperfusion Injury; Transplantation, Homologous; Tryptophan | 2021 |
Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Molecular Targeted Therapy; Neoplasms; Tryptophan; Tryptophan Oxygenase; Tumor Escape; Tumor Microenvironment | 2021 |
Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.
Topics: Antineoplastic Agents; Cell Proliferation; Gene Expression Regulation, Leukemic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Myeloid, Acute; Prognosis; Progression-Free Survival; Randomized Controlled Trials as Topic; T-Lymphocytes, Regulatory; Tryptophan; Tumor Escape; Tumor Microenvironment | 2021 |
Tryptophan Metabolism and Gut-Brain Homeostasis.
Topics: Brain; Colon; Enteric Nervous System; Gastrointestinal Microbiome; Homeostasis; Humans; Hunger; Kynurenine; Pain; Serotonin; Sleep; Tryptophan | 2021 |
Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer.
Topics: Basic Helix-Loop-Helix Transcription Factors; Carcinogenesis; Colon; Colonic Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Gastrointestinal Microbiome; Host Microbial Interactions; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Intestinal Mucosa; Kynurenine; Metabolic Networks and Pathways; Probiotics; Proto-Oncogene Proteins c-myc; Receptors, Aryl Hydrocarbon; Symbiosis; Tryptophan; Tumor Escape; Tumor Microenvironment | 2021 |
The therapeutic potential of diet on immune-related diseases: based on the regulation on tryptophan metabolism.
Topics: 3-Hydroxyanthranilic Acid; Diet; Indoles; Kynurenine; Tryptophan | 2022 |
Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis.
Topics: Bipolar Disorder; Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2021 |
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Prognosis; Quality of Life; Quinolinic Acid; Signal Transduction; Tryptophan | 2021 |
Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme.
Topics: Immune Tolerance; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism.
Topics: Animals; Gastrointestinal Microbiome; Host Microbial Interactions; Humans; Kynurenine; Metabolic Networks and Pathways; Models, Animal; Receptors, Aryl Hydrocarbon; Serotonin; Signal Transduction; Tryptophan | 2021 |
Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Inflammation; Ketamine; Kynurenine; Tryptophan | 2021 |
Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy-Kynurenines Are Important Players.
Topics: Animals; Biomarkers; Disease Progression; Humans; Kynurenine; Molecular Targeted Therapy; Multiple Sclerosis; Neurodegenerative Diseases; Signal Transduction; Tryptophan | 2021 |
Tryptophan Metabolism in Atherosclerosis and Diabetes.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system.
Topics: Colitis; Colorectal Neoplasms; Humans; Indoles; Inflammatory Bowel Diseases; Kynurenine; Serotonin; Th17 Cells; Tryptophan | 2022 |
Tryptophan metabolism and immune regulation in the human placenta.
Topics: Female; Histocompatibility, Maternal-Fetal; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Maternal-Fetal Exchange; Metabolic Networks and Pathways; Placenta; Pregnancy; Tryptophan; Tryptophan Oxygenase | 2021 |
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2021 |
Covid-19 interface with drug misuse and substance use disorders.
Topics: Adaptation, Psychological; Angiotensin-Converting Enzyme 2; Animals; Axons; Comorbidity; COVID-19; Disease Susceptibility; Drug Misuse; Endothelial Cells; Humans; Immunity, Innate; Inflammation; Kynurenine; Neurons; Neurotransmitter Agents; Olfactory Mucosa; Pandemics; SARS-CoV-2; Social Isolation; Stress, Psychological; Substance-Related Disorders; Tryptophan; Viral Tropism | 2021 |
Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.
Topics: Animals; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Serotonin; Signal Transduction; Tryptophan | 2021 |
Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan | 2021 |
Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders.
Topics: Animals; Brain; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Kynurenine; Migraine Disorders; Tryptophan | 2021 |
Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview.
Topics: Animals; Bone Diseases; COVID-19; Humans; Kynurenine; Muscular Diseases; Receptors, Aryl Hydrocarbon; SARS-CoV-2; Signal Transduction; Tryptophan | 2021 |
Brain
Topics: Animals; Biomarkers; Blood-Brain Barrier; Brain; Disease Models, Animal; Disease Susceptibility; Humans; Kynurenine; Mental Disorders; Metabolic Networks and Pathways; Phenotype; Prognosis; Research; Tryptophan | 2021 |
Tryptophan Catabolism and Inflammation: A Novel Therapeutic Target For Aortic Diseases.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Aortic Aneurysm, Abdominal; Aortitis; Atherosclerosis; Humans; Inflammation Mediators; Kynurenine; Signal Transduction; Tryptophan | 2021 |
Redressing the interactions between stem cells and immune system in tissue regeneration.
Topics: Animals; Cell Adhesion Molecules; Cell Differentiation; Cell Proliferation; COVID-19; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin-Like Growth Factor II; Interferon-gamma; Kynurenic Acid; Kynurenine; Macrophages; Mice; Muscles; Oxidative Phosphorylation; Receptors, Aryl Hydrocarbon; Regeneration; Stem Cells; Tryptophan; Tumor Necrosis Factor-alpha | 2021 |
The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives.
Topics: Analgesics; Animals; Biomarkers; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Metabolic Networks and Pathways; Neuralgia; Quinolinic Acid; Tryptophan | 2021 |
Tryptophan and its metabolites in normal physiology and cancer etiology.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2023 |
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Melatonin; Muscle, Skeletal; Sepsis; Serotonin; Tryptophan | 2021 |
The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?
Topics: Animals; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Placenta; Pregnancy; Premature Birth; Tryptophan | 2021 |
Electrochemical Determination of Kynurenine Pathway Metabolites-Challenges and Perspectives.
Topics: Kynurenine; Tryptophan | 2021 |
Small Molecules Originated from Tryptophan and their Clinical Significance as Potential Biomarkers.
Topics: Biomarkers; Humans; Kynurenine; Quality of Life; Serotonin; Tryptophan | 2022 |
Recent advances in clinical trials targeting the kynurenine pathway.
Topics: Humans; Kynurenine; Male; Nervous System Diseases; Quinolinic Acid; Tryptophan | 2022 |
Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism.
Topics: Carcinogenesis; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Liver Neoplasms; Tryptophan; Tryptophan Oxygenase; Tumor Microenvironment | 2021 |
A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.
Topics: Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
The role of indoleamine 2,3-dioxygenase in allergic disorders.
Topics: Humans; Hypersensitivity; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function.
Topics: Animals; Gastrointestinal Microbiome; Intestines; Kynurenine; Mice; Obesity; Tryptophan | 2022 |
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process.
Topics: Aging; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2022 |
Kynurenine Metabolism and Alzheimer's Disease: The Potential Targets and Approaches.
Topics: Alzheimer Disease; HIV Infections; Humans; Kynurenine; Oxidative Stress; Tryptophan | 2022 |
Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives.
Topics: Animals; Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Receptors, Aryl Hydrocarbon; Tryptophan; Tryptophan Oxygenase | 2022 |
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation.
Topics: Adaptive Immunity; Amino Acid Transport Systems, Neutral; Angiotensin-Converting Enzyme 2; Basic Helix-Loop-Helix Transcription Factors; COVID-19; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Receptors, Aryl Hydrocarbon; SARS-CoV-2; Signal Transduction; Tryptophan | 2022 |
Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease.
Topics: Biomarkers; Coronary Artery Disease; Humans; Inflammation; Kynurenine; Tryptophan | 2021 |
Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19.
Topics: COVID-19; Humans; Kynurenine; Leprosy; Peripheral Nervous System Diseases; SARS-CoV-2; Tryptophan | 2022 |
Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease.
Topics: Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Kynurenine; Serotonin; Tryptophan | 2022 |
The Role of Kynurenines Produced by Indolamine-2,3-Dioxygenase 1 in Sepsis.
Topics: Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Sepsis; T-Lymphocytes, Regulatory; Tryptophan | 2022 |
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2022 |
The tryptophan metabolism, kynurenine pathway and oxidative stress - implications for glioma pathobiology.
Topics: Brain Neoplasms; Glioma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxidative Stress; Tryptophan | 2022 |
An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway.
Topics: Animals; Biomarkers; Ecosystem; Inflammation; Kynurenine; Mammals; Tryptophan | 2022 |
The Tryptophan Catabolite or Kynurenine Pathway in Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Topics: Aged; Alzheimer Disease; Brain; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 2022 |
The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis.
Topics: COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases.
Topics: Cytokines; Humans; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid; Tryptophan | 2022 |
IDO/kynurenine pathway in cancer: possible therapeutic approaches.
Topics: Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Male; Tryptophan; Tumor Microenvironment | 2022 |
Tryptophan Metabolism in Depression: A Narrative Review with a Focus on Serotonin and Kynurenine Pathways.
Topics: Depression; Humans; Kynurenine; Metabolic Networks and Pathways; Serotonin; Tryptophan | 2022 |
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information.
Topics: 3-Hydroxyanthranilic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Levodopa; Parkinson Disease; Quinolinic Acid; Tryptophan | 2022 |
Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan-Kynurenine Metabolic System.
Topics: Animals; DNA, Mitochondrial; Humans; Kynurenine; Mitochondria; Mitochondrial Diseases; Tryptophan | 2022 |
Neuroprotective Natural Products' Regulatory Effects on Depression via Gut-Brain Axis Targeting Tryptophan.
Topics: Biological Products; Brain-Gut Axis; Depression; Kynurenine; Neuroprotective Agents; Serotonin; Tryptophan | 2022 |
Role of gut microbiota in depression: Understanding molecular pathways, recent research, and future direction.
Topics: Depression; Gastrointestinal Microbiome; Histones; Humans; Kynurenine; Probiotics; RNA, Untranslated; Tryptophan | 2023 |
The role and mechanism of tryptophan - kynurenine metabolic pathway in depression.
Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2023 |
Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy.
Topics: B7-H1 Antigen; Class I Phosphatidylinositol 3-Kinases; CTLA-4 Antigen; Enzyme Inhibitors; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melanoma; Programmed Cell Death 1 Receptor; Receptors, Aryl Hydrocarbon; Tryptophan; Tryptophan Oxygenase; Tumor Microenvironment | 2022 |
The Role of Tryptophan Metabolites in Neuropsychiatric Disorders.
Topics: Depressive Disorder, Major; Humans; Kynurenine; Proteomics; Serotonin; Tryptophan | 2022 |
Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression.
Topics: Disease Progression; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Neurodegenerative Diseases; Tryptophan | 2022 |
Targeting immunometabolism mediated by the IDO1 Pathway: A new mechanism of immune resistance in endometrial cancer.
Topics: Biomarkers; Endometrial Neoplasms; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
Gut Microbiota Regulation of AHR Signaling in Liver Disease.
Topics: Gastrointestinal Microbiome; Humans; Indoles; Kynurenine; Ligands; Liver Diseases; Receptors, Aryl Hydrocarbon; Tryptophan | 2022 |
The Tryptophan Catabolite or Kynurenine Pathway in a Major Depressive Episode with Melancholia, Psychotic Features and Suicidal Behaviors: A Systematic Review and Meta-Analysis.
Topics: Albumins; Amino Acids; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acids; Suicidal Ideation; Tryptophan | 2022 |
Role of Essential Amino Acids in Age-Induced Bone Loss.
Topics: Aged; Amino Acids, Essential; Bone Density; Cell Differentiation; Humans; Isoleucine; Kynurenine; Lysine; Methionine; Osteoblasts; Osteoporosis; Threonine; Tryptophan | 2022 |
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan | 2022 |
The association of kynurenine pathway metabolites with symptom severity and clinical features of bipolar disorder: An overview.
Topics: Affect; Bipolar Disorder; Humans; Kynurenine; Signal Transduction; Tryptophan | 2022 |
Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review.
Topics: Humans; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2022 |
Linking nervous and immune systems in psychiatric illness: A meta-analysis of the kynurenine pathway.
Topics: Bipolar Disorder; Depressive Disorder, Major; Humans; Immune System; Kynurenic Acid; Kynurenine; Tryptophan | 2023 |
Exploring the Tryptophan Metabolic Pathways in Migraine-Related Mechanisms.
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Migraine Disorders; Pain; Serotonin; Tryptophan | 2022 |
The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway.
Topics: Cytokines; Depression; Humans; Inflammation; Kynurenine; Oxidative Stress; Tryptophan | 2023 |
Kynurenine Pathway in Diabetes Mellitus-Novel Pharmacological Target?
Topics: Animals; Brain; Diabetes Mellitus; Diabetic Retinopathy; Humans; Kynurenine; Nervous System Diseases; Tryptophan | 2023 |
Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response.
Topics: Colitis, Ulcerative; Comorbidity; Depression; Humans; Inflammation; Kynurenine; Tryptophan | 2023 |
PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions.
Topics: Humans; Kynurenine; Melanoma; Peroxisome Proliferator-Activated Receptors; Skin Neoplasms; Tryptophan; Tumor Microenvironment | 2023 |
New Perspective on Anorexia Nervosa: Tryptophan-Kynurenine Pathway Hypothesis.
Topics: Animals; Anorexia Nervosa; Brain; Humans; Kynurenine; Tryptophan | 2023 |
Indoleamine 2,3-dioxygenase 1 in circumventing checkpoint inhibitor responses: Updated.
Topics: Ecosystem; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Tryptophan; Tumor Microenvironment | 2023 |
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases.
Topics: Brain; Female; Gastrointestinal Microbiome; Humans; Immune System Diseases; Kynurenine; Tryptophan | 2023 |
Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders.
Topics: Amino Acids; Female; Humans; Kynurenine; Male; Mental Disorders; Serotonin; Sex Characteristics; Tryptophan | 2023 |
Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials.
Topics: Breast Neoplasms; Female; Humans; Kynurenine; Tryptophan | 2023 |
Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Female; Inflammation; Kynurenine; Mammals; Pregnancy; Tryptophan | 2023 |
IDO/Kynurenine; novel insight for treatment of inflammatory diseases.
Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mammals; Tryptophan; Tumor Necrosis Factor-alpha | 2023 |
IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Oxidoreductases; Tryptophan; Tumor Microenvironment | 2023 |
Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Tryptophan; Tumor Microenvironment | 2023 |
Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
Topics: Autoimmune Diseases; Humans; Inflammation; Kynurenine; T-Lymphocytes; Tryptophan | 2023 |
Advances in kynurenine analysis.
Topics: Biomarkers; Chromatography, Liquid; Humans; Kynurenine; Plasma; Tryptophan | 2023 |
Kynurenine metabolite changes in individuals with alcohol use disorder: A systematic review and meta-analysis.
Topics: Alcoholism; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 2023 |
Tryptophan metabolism in health and disease.
Topics: Dioxygenases; Humans; Kynurenine; Neoplasms; Tryptophan | 2023 |
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis.
Topics: Aged; Aged, 80 and over; Frailty; Humans; Kynurenine; Osteoporosis; Sarcopenia; Tryptophan | 2023 |
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review.
Topics: Blood Platelets; Cytokines; Dysbiosis; Humans; Inflammation; Kynurenine; Neuroinflammatory Diseases; Serotonin; Tryptophan | 2023 |
The Role of Tryptophan Metabolism in the Occurrence and Progression of Acute and Chronic Kidney Diseases.
Topics: Acute Kidney Injury; Humans; Kynurenine; Renal Insufficiency, Chronic; Signal Transduction; Tryptophan | 2023 |
The kynurenine pathway in HIV, frailty and inflammaging.
Topics: Aged; Cytokines; Frailty; HIV Infections; Humans; Kynurenine; Tryptophan | 2023 |
Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease.
Topics: Indoles; Kynurenine; Melatonin; Microbiota; Tryptophan | 2023 |
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.
Topics: C-Reactive Protein; Humans; Kynurenine; Quinolinic Acid; Rheumatic Diseases; Tryptophan | 2023 |
Dietary Kynurenine Pathway Metabolites-Source, Fate, and Chromatographic Determinations.
Topics: Animals; Chromatography; Diet; Humans; Inflammation; Kynurenine; Mammals; Tryptophan | 2023 |
Suppression of Kynurenine 3-Monooxygenase as a Treatment for Triple-negative Breast Carcinoma.
Topics: Brain; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Treatment Outcome; Triple Negative Breast Neoplasms; Tryptophan | 2023 |
76 trial(s) available for tryptophan and kynurenine
| Article | Year |
|---|---|
Tryptophan-nicotinamide, imipramine and their combination in depression. A controlled study.
Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipramine; Kynurenine; Male; Middle Aged; Niacinamide; Psychiatric Status Rating Scales; Tryptophan | 1979 |
A controlled study of tryptophan-benserazide in schizophrenia.
Topics: Adult; Aged; Benserazide; Chlorpromazine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrazines; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Tryptophan | 1978 |
Effect of vitamin or amino acid supplementation on plasma free amino acid levels in South African Blacks.
Topics: Amino Acids; Ascorbic Acid; Black or African American; Black People; Humans; Kynurenine; Leucine; Male; Pyridoxine; Riboflavin; South Africa; Thiamine; Tryptophan; Vitamin B Complex | 1977 |
Metabolism of tryptophan and niacin in oral contraceptives users receiving controlled intakes of vitamin B6.
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Female; Humans; Kynurenic Acid; Kynurenine; Nicotinic Acids; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1975 |
Menstrual cycle effects on the metabolism of tryptophan loads.
Topics: Adult; Amino Acids; Creatinine; Energy Intake; Female; Follicular Phase; Humans; Kynurenine; Luteal Phase; Menstrual Cycle; Methylhistidines; Nutritional Physiological Phenomena; Serotonin; Tryptophan | 1989 |
A controlled clinical trial of L-tryptophan in acute mania.
Topics: Acute Disease; Adolescent; Adult; Bipolar Disorder; Clinical Trials as Topic; Female; Humans; Kinetics; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan | 1985 |
Studies on tryptophan metabolism in male subjects treated with female sex hormones.
Topics: Aminohippuric Acids; Chlorotrianisene; Chromatography, Ion Exchange; Clinical Trials as Topic; Diethylstilbestrol; Glucuronates; Humans; Indican; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Male; Mestranol; Niacinamide; Norethindrone; Norethynodrel; ortho-Aminobenzoates; Progestins; Prostatic Diseases; Prostatic Hyperplasia; Prostatitis; Pyridones; Pyridoxine; Spectrophotometry; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1970 |
Effect of oral contraceptives on urinary metabolite excretions after administration of L-tryptophan or L-kynurenine sulfate.
Topics: Clinical Trials as Topic; Contraceptives, Oral; Ethinyl Estradiol; Ethynodiol Diacetate; Female; Humans; Kynurenine; Mestranol; Norethindrone; Norgestrel; Tryptophan | 1973 |
Tryptophan metabolism during infectious illness in man.
Topics: Administration, Oral; Adult; Aminohippuric Acids; Clinical Trials as Topic; Diazonium Compounds; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Phlebotomus Fever; Rocky Mountain Spotted Fever; Tryptophan; Tularemia; Typhoid Fever; Xanthurenates | 1970 |
Metabolism of an oral tryptophan load. I: Effects of dose and pretreatment with tryptophan.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Protein Binding; Tryptophan | 1980 |
Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group. EORTC Genito-Urinary Tract Cancer Cooperative G
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Transitional Cell; Double-Blind Method; Europe; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Prospective Studies; Pyridoxine; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1995 |
A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: I. Comparisons with healthy control subjects and neuroleptic-treated/unmedicated pairs analyses.
Topics: Adult; Biogenic Amines; Chromatography, High Pressure Liquid; Chronic Disease; Dopamine; Double-Blind Method; Female; Haloperidol; Humans; Kynurenine; Male; Norepinephrine; Schizophrenia; Schizophrenic Psychology; Serotonin; Tryptophan; Tyrosine | 1994 |
A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: II. Correlations with psychopathology.
Topics: Adult; Biogenic Amines; Dopamine; Double-Blind Method; Female; Haloperidol; Humans; Kynurenine; Male; Norepinephrine; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Serotonin; Tryptophan; Tyrosine | 1994 |
Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Tryptophan; Viral Load | 2000 |
Free L-tryptophan plasma levels in antisocial violent offenders.
Topics: Adult; Amino Acids; Brain Chemistry; Crime; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Middle Aged; Serotonin; Tryptophan; Violence | 2001 |
Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hepatitis C, Chronic; Humans; Immunotherapy; Interferon alpha-2; Interferon-alpha; Kynurenine; Male; Middle Aged; Personality Inventory; Receptors, Serotonin; Recombinant Proteins; Serotonin; Tryptophan | 2002 |
Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation.
Topics: Adult; Anxiety; Depression; Female; Humans; Immunity; Inflammation; Interleukin-6; Interleukin-8; Kynurenine; Leukemia Inhibitory Factor Receptor alpha Subunit; Menstrual Cycle; Postpartum Period; Pregnancy; Psychiatric Status Rating Scales; Receptors, Cytokine; Receptors, OSM-LIF; Tryptophan | 2002 |
Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy.
Topics: Adolescent; Adult; Aged; Amygdala; Atrophy; Cerebral Cortex; Epilepsy, Temporal Lobe; Female; Glucose; Hippocampus; Humans; Kynurenine; Male; Middle Aged; Tomography, Emission-Computed; Tryptophan | 2003 |
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; Picolinic Acids; Quinolinic Acid; Retrospective Studies; Tryptophan; Vietnam | 2003 |
Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Depression; Double-Blind Method; Female; Humans; Interferon-alpha; Kynurenine; Male; Melanoma; Middle Aged; Neopterin; Paroxetine; Selective Serotonin Reuptake Inhibitors; Time Factors; Tryptophan | 2003 |
IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity.
Topics: Adult; Depression; Dioxygenases; Female; Follow-Up Studies; Hepatitis C, Chronic; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan | 2005 |
Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients.
Topics: Adjuvants, Immunologic; Adult; Chromatography; Female; Humans; Interferon-beta; Kynurenic Acid; Kynurenine; Male; Mass Spectrometry; Multiple Sclerosis, Relapsing-Remitting; Time Factors; Tryptophan | 2005 |
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.
Topics: Antibodies, Monoclonal; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Dendritic Cells; Female; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferons; Kynurenine; Lymphocyte Activation; Male; Plasma Cells; Tryptophan | 2007 |
Cytokine changes and tryptophan metabolites in medication-naïve and medication-free schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Cytokines; Female; Humans; Kynurenine; Male; Schizophrenia; Time Factors; Tryptophan | 2009 |
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Placebos; Protein Precursors; Quinolinic Acid; Sepsis; Serotonin; Shock, Septic; Treatment Outcome; Tryptophan | 2010 |
Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome.
Topics: Adult; Affect; Amino Acids, Neutral; Case-Control Studies; Dairy Products; Diarrhea; Diet; Female; Humans; Irritable Bowel Syndrome; Kynurenine; Male; Middle Aged; Oxidation-Reduction; Serotonin; Tryptophan; Tryptophan Oxygenase | 2010 |
3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Humans; Kynurenine; Monte Carlo Method; Neuropsychological Tests; Psychotic Disorders; Schizophrenia; Tryptophan; Young Adult | 2011 |
Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients.
Topics: Adult; Antibodies, Neutralizing; Biomarkers; Demography; Dose-Response Relationship, Drug; Female; Humans; Interferon beta-1a; Interferon-beta; Kynurenine; Male; Multiple Sclerosis; Neopterin; Time Factors; Tryptophan | 2011 |
Does acute tryptophan depletion affect peripheral serotonin metabolism in the intestine?
Topics: Adult; Central Nervous System; Double-Blind Method; Female; Humans; Hydroxyindoleacetic Acid; Intestinal Mucosa; Intestines; Kynurenic Acid; Kynurenine; Male; Serotonin; Tryptophan; Young Adult | 2012 |
An increased ratio of dietary tryptophan to lysine improves feed efficiency and elevates plasma tryptophan and kynurenine in the absence of antimicrobials and regardless of infection with enterotoxigenic Escherichia coli in weaned pigs.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Anti-Bacterial Agents; Diet; Enterotoxigenic Escherichia coli; Escherichia coli Infections; Female; Kynurenine; Lysine; Male; Swine; Swine Diseases; Tryptophan | 2012 |
Metabolites of tryptophan catabolism are elevated in sera of patients with myelodysplastic syndromes and inhibit hematopoietic progenitor amplification.
Topics: Adult; Cell Proliferation; Cells, Cultured; Female; Hematopoietic Stem Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Myelodysplastic Syndromes; Tryptophan; Tryptophan Oxygenase | 2013 |
Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Kynurenic Acid; Kynurenine; Niacinamide; ortho-Aminobenzoates; Placebos; Tryptophan; Young Adult | 2013 |
Plasma kynurenic acid/tryptophan ratio: a sensitive and reliable biomarker for the assessment of renal function.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Hypertension; Kidney Function Tests; Kynurenic Acid; Kynurenine; Male; Middle Aged; Renal Insufficiency, Chronic; Tryptophan | 2013 |
Immunomodulation and oxidative stress in denim sandblasting workers: changes caused by silica exposure.
Topics: Adolescent; Adult; Child; Environmental Monitoring; Enzyme Induction; Humans; Immunity, Cellular; Immunomodulation; Kynurenine; Male; Middle Aged; Neopterin; Occupational Diseases; Occupational Exposure; Oxidative Stress; Silicon Dioxide; Silicosis; Superoxide Dismutase; Textile Industry; Tryptophan; Young Adult | 2013 |
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Aged; Cancer Vaccines; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Statistics, Nonparametric; T-Lymphocytes, Regulatory; Treatment Outcome; Tryptophan; Vaccination | 2014 |
Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults.
Topics: Austria; Biomarkers; Body Mass Index; Caloric Restriction; Diet, Reducing; Female; Humans; Inflammation Mediators; Kynurenine; Leptin; Male; Middle Aged; Mood Disorders; Neopterin; Overweight; Phenylalanine; Risk; Tryptophan; Tyrosine; Weight Loss | 2015 |
The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy.
Topics: Adolescent; Affect; Biotransformation; Child; Child, Preschool; Double-Blind Method; Drug Resistance; Electrodes, Implanted; Epilepsy; Female; Humans; Kynurenine; Male; Metabolic Networks and Pathways; ortho-Aminobenzoates; Seizures; Treatment Outcome; Tryptophan; Vagus Nerve Stimulation | 2014 |
Elevated levels of interleukin 17A and kynurenine in candidemic patients, compared with levels in noncandidemic patients in the intensive care unit and those in healthy controls.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Candida; Candidiasis; Case-Control Studies; Female; Humans; Intensive Care Units; Interferon-gamma; Interleukin-17; Kynurenine; Lectins, C-Type; Male; Middle Aged; Prospective Studies; T-Lymphocytes, Regulatory; Toll-Like Receptor 2; Toll-Like Receptor 4; Tryptophan; Young Adult | 2015 |
Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Female; Hippocampus; Humans; Irritable Bowel Syndrome; Kynurenine; Memory Disorders; Photic Stimulation; Psychomotor Performance; Treatment Outcome; Tryptophan; Young Adult | 2015 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Metabolome; Pyridoxal Phosphate; Tryptophan; United States; Vitamin B 6; Vitamin B 6 Deficiency | 2015 |
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement.
Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Ezetimibe; Female; Healthy Volunteers; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; NF-kappa B; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Taurine; Triglycerides; Tryptophan; Uric Acid | 2015 |
Effect of increasing the dietary tryptophan to lysine ratio on plasma levels of tryptophan, kynurenine and urea and on production traits in weaner pigs experimentally infected with an enterotoxigenic strain of Escherichia coli.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Bacterial Shedding; Body Weight; Diarrhea; Diet; Dose-Response Relationship, Drug; Enterotoxigenic Escherichia coli; Escherichia coli Infections; Feces; Kynurenine; Lysine; Swine; Swine Diseases; Tryptophan; Urea | 2015 |
Early Posttransplant Tryptophan Metabolism Predicts Long-term Outcome of Human Kidney Transplantation.
Topics: Biomarkers; Biopsy; Creatinine; Early Diagnosis; Female; Humans; Immunohistochemistry; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Diseases; Kidney Function Tests; Kidney Transplantation; Kynurenine; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Time Factors; Treatment Outcome; Tryptophan | 2015 |
Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease.
Topics: Age Factors; Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Dietary Supplements; Discriminant Analysis; Female; Folic Acid; Humans; Kynurenine; Male; Mental Status Schedule; Middle Aged; ROC Curve; Thiamine; Treatment Outcome; Tryptophan; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2016 |
Tryptophan metabolism, growth responses, and postprandial insulin metabolism in weaned piglets according to the dietary provision of niacin (vitamin B) and tryptophan.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet; Dietary Supplements; Insulin; Kynurenine; Male; Niacin; Postprandial Period; Swine; Tryptophan; Vitamins | 2016 |
Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.
Topics: Adult; Athletes; Austria; Biomarkers; Double-Blind Method; Female; Gastrointestinal Microbiome; Health Status; Humans; Kynurenine; Male; Neopterin; Phenylalanine; Physical Conditioning, Human; Physical Endurance; Physical Fitness; Probiotics; Respiratory Tract Infections; Risk Factors; Seasons; Time Factors; Tryptophan; Tyrosine; Young Adult | 2016 |
Population Pharmacokinetic and Pharmacodynamic Modeling of Epacadostat in Patients With Advanced Solid Malignancies.
Topics: Adult; Aged; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Models, Biological; Neoplasms; Oximes; Sulfonamides; Tryptophan | 2017 |
Metabolomic changes demonstrate reduced bioavailability of tyrosine and altered metabolism of tryptophan via the kynurenine pathway with ingestion of medical foods in phenylketonuria.
Topics: Adolescent; Adult; Amino Acids; Biological Availability; Caseins; Catecholamines; Cross-Over Studies; Diet; Female; Food, Formulated; Gastrointestinal Microbiome; Humans; Kynurenine; Male; Melatonin; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Peptide Fragments; Phenylketonurias; Prebiotics; Serotonin; Tryptophan; Tyrosine; Young Adult | 2017 |
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyperparathyroidism, Primary; Inflammation; Kynurenine; Male; Quinolinic Acid; Tryptophan; Ventricular Remodeling | 2017 |
Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training.
Topics: Adult; Endurance Training; Exercise Therapy; Female; Humans; Kynurenine; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Tryptophan | 2018 |
No augmentation of indoleamine 2,3-dioxygenase (IDO) activity through belatacept treatment in liver transplant recipients.
Topics: Abatacept; Dendritic Cells; Female; Humans; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver Transplantation; Male; Middle Aged; Prospective Studies; Tacrolimus; Tryptophan; Up-Regulation | 2018 |
Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial.
Topics: Adrenal Insufficiency; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fatigue; Female; Humans; Hydrocortisone; Kynurenine; Male; Middle Aged; Quality of Life; Signal Transduction; Treatment Outcome; Tryptophan | 2018 |
Ileal digestibility of intrinsically labeled hen's egg and meat protein determined with the dual stable isotope tracer method in Indian adults.
Topics: Adolescent; Adult; Amino Acids; Animals; Chickens; Cooking; Dietary Proteins; Digestion; Egg Proteins; Eggs; Female; Food Analysis; Humans; Ileum; India; Isotopes; Kynurenine; Male; Meals; Meat; Meat Proteins; Middle Aged; Tryptophan; Young Adult | 2018 |
Phase I study of the indoleamine 2,3-dioxygenase 1 inhibitor navoximod (GDC-0919) as monotherapy and in combination with the PD-L1 inhibitor atezolizumab in Japanese patients with advanced solid tumours.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Asian People; B7-H1 Antigen; Female; Humans; Imidazoles; Immune Checkpoint Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Male; Middle Aged; Neoplasms; Tryptophan | 2020 |
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha | 2019 |
Nocturnal Gamma-Hydroxybutyrate Reduces Cortisol-Awakening Response and Morning Kynurenine Pathway Metabolites in Healthy Volunteers.
Topics: Adolescent; Adult; Affect; Biomarkers; Brain-Derived Neurotrophic Factor; Cross-Over Studies; Darkness; Double-Blind Method; Healthy Volunteers; Humans; Hydrocortisone; Hydroxybutyrates; Kynurenine; Male; Serotonin; Signal Transduction; Time Factors; Tryptophan; Wakefulness; Young Adult | 2019 |
Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Cohort Studies; Cross-Sectional Studies; Female; Humans; Kynurenine; Male; Middle Aged; Pyridoxal Phosphate; Tryptophan; Vitamin B 6 | 2020 |
Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging.
Topics: Bicarbonates; C-Reactive Protein; Cross-Over Studies; Down-Regulation; Female; Hemodiafiltration; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Membranes, Artificial; Middle Aged; Nitric Oxide; Renal Dialysis; Tryptophan; Vitamin E; Vitamins | 2019 |
Metabolite Profiling Revealed That a Gardening Activity Program Improves Cognitive Ability Correlated with BDNF Levels and Serotonin Metabolism in the Elderly.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain-Derived Neurotrophic Factor; Cognition; Female; Gardening; Humans; Kynurenine; Male; Metabolomics; Serotonin; Tryptophan | 2020 |
Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
Topics: Adult; Cross-Over Studies; Endurance Training; Exercise; Humans; Hydrocortisone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Male; Quinolinic Acid; Resistance Training; Transaminases; Tryptophan | 2020 |
A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; Female; Glioma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Male; Middle Aged; Neoplasm Recurrence, Local; Succinimides; Treatment Outcome; Tryptophan; Young Adult | 2020 |
Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients.
Topics: Biomarkers; Disease Progression; Down-Regulation; Humans; Interleukin-6; Kynurenine; Metabolic Networks and Pathways; Middle Aged; Pancreatic Neoplasms; Resistance Training; Tryptophan | 2021 |
Pattern of postruminal administration of l-tryptophan affects blood serotonin in cattle.
Topics: Animals; Cattle; Drug Administration Routes; Hydroxyindoleacetic Acid; Kynurenine; Male; Serotonin; Tryptophan | 2021 |
Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Exercise; Exercise Therapy; Female; Humans; Kynurenine; Male; Middle Aged; Multiple Sclerosis; Neurofilament Proteins; Prospective Studies; Single-Blind Method; Tryptophan | 2021 |
Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV.
Topics: Adult; Anti-HIV Agents; Aprepitant; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; Humans; Kynurenine; Male; Mood Disorders; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Ritonavir; Treatment Outcome; Tryptophan | 2021 |
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.
Topics: Administration, Intravenous; Adolescent; Adult; C-Reactive Protein; Cross-Over Studies; Humans; Inflammation; Interleukin-6; Kynurenine; Lipopolysaccharides; Male; Placebos; Prospective Studies; Research Subjects; Single-Blind Method; Tryptophan | 2021 |
Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet.
Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Diet, Mediterranean; Female; Heart Failure; Humans; Kynurenine; Logistic Models; Male; Metabolomics; Middle Aged; Prospective Studies; Risk Factors; Tryptophan | 2021 |
Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
Topics: Acute-On-Chronic Liver Failure; Carnitine; Humans; Kynurenine; Liver Cirrhosis; Metabolomics; Rifaximin; Simvastatin; Tryptophan | 2022 |
Metabolomic analysis of Gyejibongnyeong-Hwan for shoulder pain: A randomized, wait-list controlled pilot trial.
Topics: Arginine; Humans; Kynurenine; Metabolomics; Pilot Projects; Shoulder Pain; Tryptophan | 2022 |
Citalopram Neuroendocrine Challenge Shows Altered Tryptophan and Kynurenine Metabolism in Migraine.
Topics: Citalopram; Double-Blind Method; Female; Humans; Kynurenine; Migraine Disorders; Serotonin; Tryptophan | 2022 |
Effects of RIPC on the Metabolome in Patients Undergoing Vascular Surgery: A Randomized Controlled Trial.
Topics: Biomarkers; Cystatin C; Humans; Ischemic Preconditioning; Kynurenine; Metabolome; Troponin T; Tryptophan; Vascular Surgical Procedures | 2022 |
Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial.
Topics: Aged; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycemic Control; Humans; Insulin; Kynurenine; Muscle, Skeletal; Prospective Studies; Soybean Proteins; Tryptophan | 2022 |
Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism.
Topics: Central Nervous System; Dietary Supplements; Humans; Kynurenine; Tryptophan; Vitamin D | 2022 |
Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
Topics: Child; Crohn Disease; Diet; Humans; Kynurenine; Melatonin; Prospective Studies; Quinolinic Acid; Remission Induction; Serotonin; Tryptophan | 2023 |
The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome.
Topics: Chromatography, Liquid; Diarrhea; Diet; Fermentation; FODMAP Diet; Humans; Irritable Bowel Syndrome; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2023 |
Tryptophan challenge in individuals with schizophrenia and healthy controls: acute effects on circulating kynurenine and kynurenic acid, cognition and cerebral blood flow.
Topics: Animals; Cerebrovascular Circulation; Cognition; Cross-Over Studies; Humans; Kynurenic Acid; Kynurenine; Rats; Rats, Wistar; Schizophrenia; Tryptophan | 2023 |
1905 other study(ies) available for tryptophan and kynurenine
| Article | Year |
|---|---|
[The role of the tryptophan-62 residue in the structure and function of lysozyme].
Topics: Chemical Phenomena; Chemistry; Drug Stability; Eggs; Hydrogen-Ion Concentration; Kynurenine; Muramidase; Protein Binding; Protein Conformation; Thermodynamics; Tryptophan | 1977 |
Selective chemical cleavage of the peptide bond at N'-formylkynurenine in ozone-oxidized hen egg-white lysozyme.
Topics: Amino Acids; Animals; Chickens; Egg White; Hydrogen-Ion Concentration; Kynurenine; Muramidase; Oxidation-Reduction; Ozone; Peptide Fragments; Spectrophotometry, Ultraviolet; Tryptophan | 1977 |
Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency.
Topics: 11-Hydroxycorticosteroids; Animals; Erythrocytes; Haplorhini; Kynurenine; Male; NAD; NADP; Papio; Riboflavin Deficiency; Tryptophan; Vitamin B 6 Deficiency | 1975 |
Monoamine mechanisms in chronic schizophrenia: post-mortem neurochemical findings.
Topics: Aged; Brain Chemistry; Catechol O-Methyltransferase; Chronic Disease; Dopamine; Dopamine beta-Hydroxylase; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Monoamine Oxidase; Norepinephrine; Phenylacetates; Schizophrenia; Serotonin; Tryptophan; Tyrosine 3-Monooxygenase | 1979 |
On the regulation of tryptophan metabolism "via" kynurenine.
Topics: Animals; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenine; Mixed Function Oxygenases; NAD; NADP; Nicotinic Acids; ortho-Aminobenzoates; Phenylalanine; Rats; Serotonin; Solubility; Tryptophan; Xanthurenates | 1978 |
Preparation and characterization of an active lysozyme derivative: Kyn 62-lysozyme.
Topics: Amino Acids; Egg White; Hydrogen-Ion Concentration; Kinetics; Kynurenine; Muramidase; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Temperature; Tryptophan | 1979 |
[De novo biosynthesis of nicotinic acid in candida lipolytica].
Topics: 3-Hydroxyanthranilic Acid; Arylformamidase; Candida; Hydrolases; Kynurenine; Methylnitronitrosoguanidine; Mixed Function Oxygenases; Mutagens; Mutation; Nicotinic Acids; Rhodotorula; Tryptophan; Tryptophan Oxygenase | 1975 |
Kynurenine formamidase inhibition as a possible mechanism for certain teratogenic effects of organophosphorus and methylcarbamate insecticides in chicken embryos.
Topics: Amidohydrolases; Animals; Arylformamidase; Carbamates; Chick Embryo; Chickens; In Vitro Techniques; Insecticides; Kynurenine; Liver; Male; Mice; NAD; Organophosphorus Compounds; Structure-Activity Relationship; Teratogens; Tryptophan; Tryptophan Oxygenase | 1977 |
Importance of tryptophan pyrrolase and aromatic amino acid decarboxylase in the catabolism of tryptophan.
Topics: Amino Acids; Animals; Arylformamidase; Benserazide; Carbon Dioxide; Carboxy-Lyases; Kynurenine; Liver; Male; Rats; Time Factors; Tryptophan; Tryptophan Oxygenase | 1978 |
Nutritive value of N-acetyl-L-tryptophan in man.
Topics: Blood Proteins; Deuterium; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Nutritive Value; Tryptophan | 1979 |
Brain tryptophan metabolism in schizophrenia: a post mortem study of metabolites of the serotonin and kynurenine pathways in schizophrenic and control subjects.
Topics: Aged; Aging; Brain; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Middle Aged; Myocardial Infarction; Postmortem Changes; Schizophrenia; Serotonin; Sex Factors; Tryptophan | 1979 |
[Motor activity of tryptophan--xanthommatin metabolic pathway mutants in Drosophila melanogaster].
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Drosophila melanogaster; Kynurenine; Metamorphosis, Biological; Motor Activity; Mutation; Tryptophan | 1979 |
[Studies on tryptophan metabolism in untreated phenylketonuric patients].
Topics: Acetophenones; Adolescent; Adult; Biotransformation; Child; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Thin Layer; Female; Humans; Kynurenic Acid; Kynurenine; Male; Mass Spectrometry; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Phenylalanine; Phenylketonurias; Quinolines; Tryptophan; Xanthurenates | 1975 |
A defect in tryptophan metabolism.
Topics: Cerebellar Ataxia; Child; Chromatography, Paper; Drug Eruptions; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Clearance Rate; Metabolism, Inborn Errors; Nicotinic Acids; Photosensitivity Disorders; Tryptophan; Xanthurenates | 1976 |
[Tryptophan-load in progressive scleroderma (author's transl)].
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Male; Niacinamide; Scleroderma, Systemic; Serotonin; Skin; Tryptamines; Tryptophan; Xanthurenates | 1976 |
Crystalline inducible kynureninase of Neurospora crassa.
Topics: Crystallization; Enzyme Induction; Hydrolases; Kynurenine; Neurospora; Neurospora crassa; Pseudomonas; Species Specificity; Tryptophan | 1976 |
Tryptophan metabolism "via" nicotimic acid in patients with scleroderma.
Topics: Adult; Aged; Female; Humans; Kynurenine; Middle Aged; Niacinamide; Nicotinic Acids; Pyridoxine; Scleroderma, Localized; Scleroderma, Systemic; Tryptophan | 1976 |
Tryptophan metabolism in relation to amino acid alterations during typhoid fever.
Topics: Amino Acids; Humans; Kynurenine; Liver; Niacinamide; Tryptophan; Typhoid Fever; Xanthurenates | 1975 |
[Tryptophan metabolism and oligophrenia (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Down Syndrome; Epilepsy; Hartnup Disease; Humans; Intellectual Disability; Kynurenine; Pyridoxine; Tryptophan; Xanthurenates | 1978 |
A pyridoxine-dependent behavioral disorder unmasked by isoniazid.
Topics: Child Behavior Disorders; Child, Preschool; Female; Humans; Hyperkinesis; Isoniazid; Kynurenine; Niacinamide; Pyridoxine; Substance Withdrawal Syndrome; Tryptophan | 1978 |
Comparison of inducible and constitutive kynureninases of Neurospora crassa.
Topics: Enzyme Induction; Hydrolases; Immune Sera; Immunoassay; Immunodiffusion; Kynurenine; Neurospora; Neurospora crassa; Species Specificity; Tryptophan | 1979 |
Kynureninase-Type enzymes of Penicillum roqueforti, Aspergillus niger, Rhizopus stolonifer, and Pseudomonas fluorescens: further evidence for distinct kynureninase and hydroxykynureninase activities.
Topics: Ammonium Sulfate; Aspergillus; Cell Fractionation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Induction; Hydrolases; Hydroxylation; Kynurenine; NAD; ortho-Aminobenzoates; Penicillium; Protamines; Pseudomonas fluorescens; Rhizopus; Species Specificity; Tryptophan | 1975 |
NAD precursors as antiteratogens against aminothiadiazole.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Resorption; Gestational Age; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; Pregnancy; Quinolinic Acids; Rats; Teratogens; Thiadiazoles; Tryptophan | 1976 |
[Studies of tryptophan metabolism of streptomycetes. IV. Studies of the inhibition of enzyme of tryptophan metabolism].
Topics: Azides; Cell-Free System; Cyanides; Ditiocarb; Kynurenine; ortho-Aminobenzoates; Phenanthrolines; Streptomyces; Tryptophan; Tryptophan Oxygenase | 1975 |
Kynureninase-type enzymes and the evolution of the aerobic tryptophan-to-nicotinamide adenine dinucleotide pathway.
Topics: Animals; Anura; Biological Evolution; Chickens; Fungi; Hydrolases; Kynurenine; Liver; Mice; NAD; Pseudomonas fluorescens; Species Specificity; Trout; Tryptophan; Turtles; Xanthomonas | 1977 |
[Tryptophan metabolism and oligophrenia. Part 2: Personal studies].
Topics: Adolescent; Adult; Child; Humans; Intellectual Disability; Kynurenine; Pyridoxine; Serotonin; Tryptophan; Xanthurenates | 1978 |
Structural specificity of the carrier for L-tryptophan in rat cerebral cortex slices.
Topics: Animals; Biological Transport, Active; Cerebral Cortex; In Vitro Techniques; Isoleucine; Kynurenine; Leucine; Phenylalanine; Rats; Tryptophan; Tyrosine; Valine | 1979 |
Tryptophan loading: consequent effects on the synthesis of kynurenine and 5-hydroxyindoles in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Fasting; Hydroxyindoleacetic Acid; Kynurenine; Male; Rats; Serotonin; Tryptophan | 1978 |
[Excitability of the neuromuscular apparatus of strains of Drosophila melanogaster with mutant genes controlling the kynurenine pathway of tryptophan metabolism].
Topics: Animals; Drosophila melanogaster; Kynurenine; Mutation; Neuromuscular Junction; Tryptophan | 1977 |
Plasma neutral amino acids in mania and depression: variation during acute and prolonged treatment with L-tryptophan.
Topics: Amino Acids; Bipolar Disorder; Female; Humans; Isoleucine; Kynurenine; Leucine; Middle Aged; Tryptophan; Tyrosine; Valine | 1979 |
[Tryptophan metabolic indices in allergic dermatoses].
Topics: Chronic Disease; Dermatitis, Atopic; Female; Humans; Kynurenic Acid; Kynurenine; Male; Prurigo; Pyridoxal Phosphate; Tryptophan; Urticaria; Xanthurenates | 1979 |
The vitamin B6 requirement in oral contraceptive users. II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine.
Topics: Adolescent; Adult; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Female; Humans; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Nutritional Requirements; Pyridoxic Acid; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1979 |
Relationship between tryptophan intake and urinary excretion of 3-hydroxy-kynurenine, 3-hydroxyanthranilic acid, xanthurenic acid and kynurenic acid.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Kinetics; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1979 |
Tryptophan metabolism in bladder cancer patients from Copenhagen.
Topics: Denmark; Humans; Kynurenine; Male; Pyridoxal Phosphate; Pyridoxic Acid; Tryptophan; Urinary Bladder Neoplasms | 1979 |
[Photosensitivity and disturbances of tryptophan metabolism (kynurenin pathway) (author's transl)].
Topics: Aged; Animals; Female; Humans; Kynurenine; Pellagra; Photosensitivity Disorders; Rats; Tryptophan | 1979 |
Kynurenine: penetration to the brain, effect on brain tryptophan and 5-hydroxytryptamine metabolism and binding to plasma albumin [proceedings].
Topics: Animals; Brain; Kynurenine; Male; Protein Binding; Rats; Serotonin; Serum Albumin; Tryptophan | 1979 |
Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Indoles; Kynurenine; Tryptophan | 1979 |
Tryptophan metabolism in animals with dermatitis. I) In Rats.
Topics: Animals; Dermatitis, Contact; Ficusin; Kynurenic Acid; Kynurenine; Photosensitivity Disorders; Rats; Tryptophan; Xanthurenates | 1979 |
Tryptophan metabolism in animals with dermatitis. II) In guinea pigs.
Topics: Animals; Dermatitis, Contact; Ficusin; Guinea Pigs; Kynurenine; Photosensitivity Disorders; Tryptophan; Xanthurenates | 1979 |
The spontaneous urinary excretion of tryptophan metabolites "via kynurenine" in women with regards to the prepuberty, sexual maturity and menopause.
Topics: Adult; Age Factors; Aged; Aminohippuric Acids; Child; Female; Humans; Kynurenic Acid; Kynurenine; Menopause; Middle Aged; ortho-Aminobenzoates; Puberty; Sexual Maturation; Tryptophan; Xanthurenates | 1978 |
The effect of allopurinol on the kynurenine formation in humans following a tryptophan load.
Topics: Allopurinol; Bipolar Disorder; Humans; Kynurenine; Tryptophan | 1978 |
A further contribution to the choice of the dose for L-tryptophan load test.
Topics: Aminohippuric Acids; Body Weight; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Sex Factors; Tryptophan; Xanthurenates | 1978 |
The effect of environment on tryptophan metabolism "via kynurenine" in oral contraceptives users.
Topics: Aminohippuric Acids; Contraceptives, Oral; Contraceptives, Oral, Combined; Environment; Ethinyl Estradiol; Female; Humans; Kynurenic Acid; Kynurenine; Norethindrone; ortho-Aminobenzoates; Pregnancy; Rural Population; Tryptophan; Urban Population; Xanthurenates | 1978 |
Influence of vitamin and amino acid supplements on tryptophan-kynurenine metabolism in South African Bantu.
Topics: Adult; Aminohippuric Acids; Ascorbic Acid; Humans; Kynurenic Acid; Kynurenine; Leucine; ortho-Aminobenzoates; Pyridoxine; Racial Groups; Riboflavin; South Africa; Thiamine; Tryptophan; Vitamins; Xanthurenates | 1978 |
[Toxicity and tolerance of tryptophan and its metabolites].
Topics: Animals; Cats; Diarrhea; Dogs; Guinea Pigs; Humans; Kynurenine; Mice; ortho-Aminobenzoates; Rabbits; Rats; Sleep Wake Disorders; Tryptophan; Vomiting; Xanthurenates | 1978 |
[Biochemical paths to the effect of mutation snow on the neurological characteristics of the honey bee].
Topics: Anesthesia; Animals; Bees; Ether; Kynurenine; Mutation; Nervous System; Nervous System Physiological Phenomena; Time Factors; Tryptophan | 1977 |
Tryptophan and hydrogen sulfide reaction from modified trypticase soy agar.
Topics: Agar; Bacteria; Citrates; Ferric Compounds; Hydrogen Sulfide; Indoles; Kynurenine; Organometallic Compounds; ortho-Aminobenzoates; Phenylpyruvic Acids; Thiosulfates; Tryptophan | 1978 |
A new aspect of the urinary excretion of tryptophan metabolites in patients with cancer of the bladder.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Aspartate Aminotransferases; Creatinine; Female; Humans; Kidney Neoplasms; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sodium; Tryptophan; Urea; Ureteral Obstruction; Urinary Bladder Neoplasms; Xanthurenates | 1978 |
Tryptophan metabolism in Japanese and British women and its relationship to endogenous steroid levels.
Topics: 3-Hydroxyanthranilic Acid; Asian People; Breast Neoplasms; Estradiol; Female; Hormones; Humans; Hydrocortisone; Japan; Kynurenine; Menopause; Tryptophan; United Kingdom; White People; Xanthurenates | 1978 |
Familial hydroxykynureninuria.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Consanguinity; Female; Gingival Diseases; Humans; Intellectual Disability; Kynurenine; Male; Pedigree; Stomatitis; Syndrome; Tryptophan; Xanthurenates | 1978 |
Metabolism of an oral tryptophan load by women and evidence against the induction of tryptophan pyrrolase by oral contraceptives.
Topics: Adult; Contraceptives, Oral; Enzyme Induction; Female; Half-Life; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Time Factors; Tryptophan; Tryptophan Oxygenase | 1978 |
Brain tryptophan metabolism on the 5-hydroxytryptamine and kynurenine pathways in a strain of rats with a deficiency in platelet 5-HT.
Topics: Animals; Blood Platelets; Brain; Hydroxyindoleacetic Acid; Kynurenine; Male; Pargyline; Rats; Reserpine; Serotonin; Tryptophan | 1978 |
Indoleamine 2,3-dioxygenase. Formation of L-kynurenine from L-tryptophan in cultured rabbit fineal gland.
Topics: Animals; Brain; Indoles; Kynurenine; Male; Oxygenases; Pineal Gland; Rabbits; Tissue Distribution; Tryptophan | 1978 |
The degradation of tryptophan in severe liver disease.
Topics: Acute Disease; Chronic Disease; Humans; Kynurenine; Liver Diseases; Tryptophan; Vitamins | 1978 |
Selective ion monitoring of tryptophan, N-acetyltryptophan and kynurenine in human serum. Application to the in vivo measurement of tryptophan pyrrolase activity.
Topics: Acetylation; Deuterium; Humans; Kynurenine; Monitoring, Physiologic; Trimethylsilyl Compounds; Tryptophan; Tryptophan Oxygenase | 1978 |
[Tryptophan metabolism via the kynurenine and serotonin pathways in pregnancy nephropathy].
Topics: Female; Humans; Kidney Diseases; Kynurenine; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Serotonin; Tryptophan | 1978 |
The metabolism of a tryptophan load in rat brain and liver: the influence of L-alpha-methyldopa hydrazine (MK-486, Carbidopa).
Topics: Animals; Brain; Carbidopa; Hydrazines; Kynurenine; Liver; Male; Metabolic Clearance Rate; Rats; Tryptophan; Tryptophan Oxygenase | 1978 |
Xanthommatin biosynthesis in wild-type and mutant strains of the Australian sheep blowfly Lucilia cuprina.
Topics: Amino Acids; Animals; Diptera; Eye Color; Kynurenine; Mutation; Oxazines; Pigments, Biological; Tryptophan; Tryptophan Oxygenase; Xanthenes | 1978 |
Transport of D- and L-tryptophan in Bacillus megaterium by an inducible permease.
Topics: Arginine; Azides; Bacillus megaterium; Biological Transport, Active; Carbon Radioisotopes; Chloramphenicol; Enzyme Induction; Enzyme Repression; Kinetics; Kynurenine; Leucine; Membrane Transport Proteins; Phenylalanine; Stereoisomerism; Tryptophan | 1975 |
Tryptophan catabolism in Bacillus megaterium.
Topics: Alanine; Arginine; Bacillus megaterium; Catechols; Cell-Free System; Enzyme Induction; Enzyme Repression; Glucose; Hydrolases; Kynurenine; ortho-Aminobenzoates; Oxidation-Reduction; Oxygen Consumption; Oxygenases; Tryptophan | 1975 |
A biochemical study of the scarlet eye-color mutant of Drosophila melanogaster.
Topics: Animals; Carbon Radioisotopes; Chromatography, Paper; Drosophila melanogaster; Eye; Female; Kynurenine; Larva; Male; Mutation; Phenotype; Pigmentation; Pupa; Tryptophan; Xanthurenates | 1975 |
[Role of 02- ions in formation of N'-formylkynurenine from tryptophan].
Topics: Anions; Electrochemistry; Kynurenine; Oxygen; Radiochemistry; Tryptophan | 1975 |
Experimental biharzial bladder cancer: tryptophan metabolism in nonhuman primates experimentally infected with Schistosoma haematobium.
Topics: 3-Hydroxyanthranilic Acid; Animals; Disease Models, Animal; Haplorhini; Kynurenine; Liver; Neoplasms, Experimental; Papio; Schistosomiasis; Tryptophan; Tryptophan Oxygenase | 1976 |
Plasma amino acids as an index for subgroups in manic depressive psychosis: correlation to effect of tryptophan.
Topics: Amino Acids; Bipolar Disorder; Drug Resistance; Female; Humans; Kynurenine; Male; Serotonin; Tryptophan | 1976 |
Effects of vitamin B-6 deficiency and tryptophan loading on urinary excretion of tryptophan metabolites in mammals.
Topics: Adult; Animals; Cricetinae; Diet; Female; Guinea Pigs; Humans; Kynurenic Acid; Kynurenine; Pyridoxine; Quinolinic Acids; Rats; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1977 |
Metabolism of 14C-labelled L-tryptophan, L-kynurenine and hydroxy-L-kynurenine in miners with scleroderma.
Topics: Carbon Dioxide; Humans; Kynurenine; Male; Middle Aged; Mining; Nicotinic Acids; Occupational Diseases; Quinolinic Acids; Scleroderma, Systemic; Tryptophan | 1977 |
Some research on parapsoriasis and lymphomas.
Topics: Adult; Humans; Kynurenine; Lymphoma; Male; Middle Aged; Nicotinic Acids; Parapsoriasis; Precancerous Conditions; Skin; Skin Neoplasms; Tryptophan | 1977 |
Effects of benserazide on tryptophan metabolism in the mouse.
Topics: Animals; Benserazide; Carbon Dioxide; Hydrazines; Hydrolases; In Vitro Techniques; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Time Factors; Transaminases; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1977 |
[The role of L-tryptophan's promoting factor on tumorgenesis in the urinary bladder. 1. A study on the urinary tryptophan metabolites (author's transl)].
Topics: Adolescent; Adult; Aged; Female; Humans; Kynurenine; Male; Middle Aged; Tryptophan; Urinary Bladder Neoplasms | 1977 |
[Tryptophan metabolism in breast carcinoma].
Topics: Aged; Breast Neoplasms; Female; Humans; Kynurenine; Menopause; Middle Aged; Postoperative Complications; Tryptophan; Xanthurenates | 1976 |
Identification of tryptophan 62 as an ozonization-sensitive residue in hen egg-white lysozyme.
Topics: Amino Acids; Egg White; Kynurenine; Muramidase; Ozone; Peptide Fragments; Tryptophan | 1976 |
Abnormal tryptophan metabolism in a family with a history of bladder cancer.
Topics: Aged; Female; Humans; Kynurenine; Male; Metabolism, Inborn Errors; Middle Aged; Pyridoxine; Tryptophan; Urinary Bladder Neoplasms | 1976 |
Enrichment of enzyme activity on deformylation of 1-NFK-lysozyme.
Topics: Binding Sites; Chromatography, Affinity; Egg White; Formamides; Kinetics; Kynurenine; Muramidase; Ozone; Peptide Fragments; Protein Binding; Temperature; Trypsin; Tryptophan | 1976 |
[Relationship between tryptophan metabolism and the state of melaninogensis].
Topics: Animals; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Melanins; ortho-Aminobenzoates; Rabbits; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1976 |
[Nature of tryptophan photooxidation products in lysozyme in the presence of methylene blue].
Topics: Chitin; Chromatography, Affinity; Hydrolysis; Kynurenine; Methylene Blue; Micrococcus; Muramidase; Oxygen; Photosynthesis; Spectrophotometry, Ultraviolet; Tryptophan | 1976 |
Abnormal tryptopham metabolism in congenital erythroid hypoplastic (Diamond-Blackfan) anaemia.
Topics: Anemia, Aplastic; Humans; Infant; Infant, Newborn; Kynurenine; Liver; Male; ortho-Aminobenzoates; Tryptophan | 1976 |
The effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet.
Topics: 3-Hydroxyanthranilic Acid; 5-Hydroxytryptophan; Animals; Brain; Depression; Diet; Drug Synergism; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1975 |
Functional capacity of the tryptophan-niacin pathway in the premenarchial phase and in the menopausal age.
Topics: Adult; Child; Estradiol; Female; Humans; Kynurenine; Male; Menarche; Menopause; Middle Aged; Nicotinic Acids; Pyridoxine; Tryptophan | 1975 |
A mechanism for the formation in vivo of the 8-methyl ether of xanthurenic acid in humans.
Topics: Adult; Female; Humans; Kynurenic Acid; Kynurenine; Male; Methionine; Methyl Ethers; Middle Aged; Pellagra; Scleroderma, Systemic; Time Factors; Tryptophan; Xanthurenates | 1975 |
Liver and brain tryptophan metabolism following hydrocortisone administration to rats and gerbils.
Topics: Animals; Brain; Gerbillinae; Hydrocortisone; Hydroxyindoleacetic Acid; Kynurenine; Liver; Male; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1975 |
A new method for determination of urinary tryptophan metabolites in bladder carcinoma.
Topics: 3-Hydroxyanthranilic Acid; Chromatography, Thin Layer; Female; Humans; Kynurenic Acid; Kynurenine; Male; Spectrometry, Fluorescence; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1975 |
The uptake of 14C-labeled hydroxyanthranilic acid and enantiomers of tryptophan, kynurenine, and hydroxykynurenine in human blood.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Isomerism; Kynurenine; Middle Aged; ortho-Aminobenzoates; Scleroderma, Systemic; Tryptophan | 1975 |
The determination of kynurenine in plasma.
Topics: Administration, Oral; Adult; Colorimetry; Evaluation Studies as Topic; Humans; Kynurenine; Male; Time Factors; Tryptophan | 1975 |
Plasma pyridoxal phosphate levels and tryptophan metabolism in children with burns and scalds.
Topics: Burns; Child; Child, Preschool; Humans; Kynurenic Acid; Kynurenine; Pyridoxal Phosphate; Pyridoxine; Tryptophan; Xanthurenates | 1975 |
Relationship of brain monoamine and locomotor activity in rats.
Topics: Animals; Body Temperature; Brain; Hydroxydopamines; Kinetics; Kynurenine; Male; Monoamine Oxidase Inhibitors; Motor Activity; Pargyline; Rats; Reserpine; Serotonin; Tranylcypromine; Tryptamines; Tryptophan | 1975 |
Proceedings: Tryptophan metabolism by the isolated perfused rat liver.
Topics: Allopurinol; Hydrocortisone; Kynurenine; Liver; Perfusion; Tryptophan | 1975 |
[State of interstitial metabolism of tryptophan during pregnancy and labor in women having received estrogen-progestagenic preparations].
Topics: Adult; Contraceptives, Oral; Estradiol Congeners; Female; Humans; Kynurenic Acid; Kynurenine; Labor, Obstetric; Middle Aged; Pregnancy; Progesterone Congeners; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1975 |
Urinary tryptophan metabolites: assay of free and acid hydrolyzable conjugates of 3-hydroxykynurenine and 3-hydroxyanthranilic acid.
Topics: 3-Hydroxyanthranilic Acid; Colorimetry; Humans; Kynurenine; ortho-Aminobenzoates; Temperature; Tryptophan | 1975 |
Oxidation of tryptophan in lysozyme by ozone in aqueous solution.
Topics: Amino Acids; Formates; Kynurenine; Micrococcus; Muramidase; Oxidation-Reduction; Ozone; Spectrum Analysis; Trypsin; Tryptophan | 1975 |
[Determination of kynureninase activity in oligophrenic children with hereditary taint, before and after vitamin B6 treatment].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Humans; Hydrolases; Intellectual Disability; Kynurenine; Pyridoxine; Tryptophan | 1975 |
The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine.
Topics: Animals; Cricetinae; Ethanol; Fatty Acids, Nonesterified; Guinea Pigs; Humans; Kynurenine; Liver; Male; Morphine; Phenobarbital; Rats; Species Specificity; Substance Withdrawal Syndrome; Tryptophan; Tryptophan Oxygenase | 1975 |
Tryptophan metabolism and recurrence rates of patients with breast cancer after mastectomy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Age Factors; Aged; Breast Neoplasms; Female; Humans; Kynurenine; Mastectomy; Menopause; Middle Aged; Time Factors; Tryptophan | 1975 |
Studies on tryptophan metabolism in Danish bladder cancer patients.
Topics: Denmark; Humans; Kynurenine; Male; Tryptophan; Urinary Bladder Neoplasms | 1975 |
Twenty years of tryptophan studies in humans.
Topics: Breast Neoplasms; Female; Humans; Hydrocortisone; Kynurenine; Liver; Neoplasm Metastasis; Tryptophan | 1975 |
The excretion of tryptophan metabolites in patients with different forms of haemoblastosis.
Topics: Hematologic Diseases; Hodgkin Disease; Humans; Kynurenine; Leukemia; Lymphoma; Tryptophan | 1975 |
Effect of phototherapy on the urinary excretion of tryptophan metabolites in neonatal hyperbilirubinemia.
Topics: Fluorescence; Humans; Infant, Newborn; Jaundice, Neonatal; Kynurenine; Light; Photolysis; Tryptophan; Ultraviolet Rays | 1975 |
Effects of oral contraceptives on tryptophan metabolism and vitamin B6 requirements in women.
Topics: Adult; Contraceptives, Oral; Cystathionine; Female; Humans; Kynurenine; Methionine; Pyridoxal Phosphate; Pyridoxine; Sex Factors; Tryptophan; Vitamin B 6 Deficiency | 1975 |
Research on tryptophan metabolites "via kynurenine" in epidermis of man and mouse.
Topics: Animals; Humans; Kynurenine; Mice; Skin; Skin Diseases; Species Specificity; Tryptophan | 1975 |
Tryptophan metabolism in skin diseases.
Topics: Animals; Humans; Kynurenine; Skin Diseases; Sunlight; Tryptophan | 1975 |
Tryptophan metabolism in untreated phenylketonuria.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Humans; Indoles; Kynurenine; Phenylketonurias; Tryptophan | 1975 |
Tryptophan metabolism in various nutritive conditions.
Topics: Animals; Diet; Epinephrine; Hydroxyindoleacetic Acid; Kynurenine; Nicotinic Acids; ortho-Aminobenzoates; Phenylalanine; Pyridoxine; Quinolines; Rats; Serotonin; Starvation; Tryptophan; Xanthurenates | 1975 |
Tryptophan metabolism in Cicer arietinum.
Topics: Kynurenine; ortho-Aminobenzoates; Plants; Tryptophan; Tryptophan Oxygenase | 1975 |
Quantitative analysis of tryptophan metabolites in urine of normal and endotoxin poisoned mice.
Topics: Animals; Chromatography, Thin Layer; Endotoxins; Kynurenine; Mice; Serotonin; Tryptophan | 1975 |
Metabolism of D- and L-tryptophan in dogs.
Topics: Animals; Carbon Dioxide; Dogs; Feces; Humans; Kynurenic Acid; Kynurenine; Liver; Male; Pyruvates; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Tryptophan | 1976 |
Tryptophan metabolism in the isolated perfused liver of the rat: effects of tryptophan concentration, hydrocortisone and allopurinol on tryptophan pyrrolase activity and kynurenine formation.
Topics: Age Factors; Allopurinol; Animals; Cycloheximide; Hydrocortisone; In Vitro Techniques; Kynurenine; Liver; Male; Rats; Time Factors; Tryptophan; Tryptophan Oxygenase | 1976 |
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1992 |
The hydroxylation of tryptophan.
Topics: Ascorbic Acid; Chromatography, High Pressure Liquid; Edetic Acid; Ferric Compounds; Gamma Rays; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxides; Hydroxyl Radical; Hydroxylation; Iron; Kynurenine; Macromolecular Substances; Nitrous Oxide; Oxygen; Photochemistry; Pulse Radiolysis; Spectrophotometry; Tryptophan | 1992 |
Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Energy Metabolism; Free Radicals; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Middle Aged; Parkinson Disease; Purines; Tryptophan; Tyrosine | 1992 |
Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Epilepsy; Kynurenine; Male; Mice; Serotonin; Tryptophan; Tyrosine | 1992 |
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
Topics: Adrenal Cortex Hormones; Adult; Aged; Eosinophilia-Myalgia Syndrome; Female; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Quinolinic Acid; Scleroderma, Systemic; Tryptophan | 1992 |
[Changes in CSF tryptophan metabolite levels in infantile spasms].
Topics: Female; Humans; Infant; Kynurenine; Male; Serotonin; Spasms, Infantile; Tryptophan | 1992 |
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1992 |
Oxidative tryptophan metabolism in renal allograft recipients: increased kynurenine synthesis is associated with inflammation and OKT3 therapy.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Biomarkers; Creatinine; Female; Graft Rejection; Gram-Negative Bacterial Infections; Humans; Inflammation; Interferon-gamma; Kidney Transplantation; Kynurenine; Male; Middle Aged; Muromonab-CD3; Oxidation-Reduction; Postoperative Complications; Predictive Value of Tests; Retrospective Studies; Tryptophan; Tryptophan Oxygenase; Virus Diseases | 1992 |
[Tryptophan and its metabolite concentrations in human plasma during the perinatal period].
Topics: Chromatography, High Pressure Liquid; Embryonic and Fetal Development; Female; Fetal Blood; Humans; Infant, Newborn; Kynurenine; Maternal-Fetal Exchange; Pregnancy; Tryptophan | 1992 |
Kynurenine pathway abnormalities in Parkinson's disease.
Topics: Aged; Autopsy; Brain; Female; Humans; Kynurenine; Male; Parkinson Disease; Tryptophan; Tyrosine | 1992 |
Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome.
Topics: Arthritis, Rheumatoid; Biopterins; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsaturated; Humans; Kynurenine; Neopterin; Plant Oils; Quinolinic Acid; Quinolinic Acids; Rapeseed Oil; Reference Values; Scleroderma, Systemic; Syndrome; Tryptophan | 1992 |
Peak E contaminated L-tryptophan and immune activation.
Topics: Biopterins; Drug Contamination; Humans; Immunity, Cellular; Kynurenine; Leukocytes, Mononuclear; Neopterin; Tryptophan; Tryptophan Oxygenase | 1991 |
Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan.
Topics: Adult; Aged; Eosinophilia; Fascia; Fasciitis; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Middle Aged; Muscles; Scleroderma, Systemic; Skin; Tryptophan | 1990 |
Intravenous heme-albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme pools.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Analysis of Variance; Cytochrome P-450 Enzyme System; Female; Hemin; Humans; Hydroxyindoleacetic Acid; Infusions, Intravenous; Kynurenine; Liver; Middle Aged; Porphobilinogen; Porphyrias; Porphyrins; Serum Albumin; Tryptophan | 1991 |
Inhibition studies on liver arylformamidases of rainbow trout and cattle.
Topics: Amino Acids; Animals; Arylformamidase; Ascorbic Acid; Cations, Divalent; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Edetic Acid; Kinetics; Kynurenine; Liver; Species Specificity; Trout; Tryptophan | 1991 |
L-tryptophan-induced eosinophilia-myalgia syndrome. II. Partial correction of abnormal tryptophan metabolism by pyridoxine.
Topics: Adult; Eosinophilia-Myalgia Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Middle Aged; Pyridoxine; Serotonin; Tryptophan | 1991 |
Effects of tryptophan 2,3-dioxygenase inhibitors in the rat.
Topics: Animals; Anxiety; Brain; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Kynurenine; Liver; Organic Chemicals; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1991 |
Tryptophan metabolism in mice infected with Schistosoma mansoni.
Topics: Animals; Cells, Cultured; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Niacinamide; Schistosomiasis mansoni; Serotonin; Tryptophan; Xanthurenates | 1991 |
Tryptophan metabolism in healthy subjects: influence of pyridoxine after single or repeated administrations.
Topics: Adult; Biological Transport; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Middle Aged; Pyridoxine; Serotonin; Tryptophan | 1991 |
Increased L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid concentrations in cerebral cortex following systemic endotoxin administration.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Quinolinic Acid; Quinolinic Acids; Serotonin; Stimulation, Chemical; Tryptophan | 1991 |
Tryptophan and its metabolites in a family with Hartnup disease.
Topics: Adolescent; Adult; Child; Female; Hartnup Disease; Humans; Hydroxyindoleacetic Acid; Intestinal Absorption; Kidney Tubules, Proximal; Kynurenine; Male; Tryptophan; Xanthurenates | 1991 |
Mutagenic activities of tryptophan metabolites before and after nitrite treatment.
Topics: Biotransformation; Hydrogen-Ion Concentration; Indoles; Kynurenine; Molecular Structure; Mutagens; Nitrites; Salmonella typhimurium; Serotonin; Tryptophan | 1991 |
The role of tryptophan and kynurenine transport in the catabolism of tryptophan through indoleamine 2,3-dioxygenase.
Topics: Adenocarcinoma; Amino Acid Transport Systems; Animals; Biological Transport; Carrier Proteins; Enzyme Induction; Interferon-gamma; Kynurenine; Liver; Mice; Neoplasm Proteins; Rats; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 1991 |
Kynureninase and kynurenine 3-hydroxylase in mammalian tissues.
Topics: Animals; Eulipotyphla; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mitochondria; Mixed Function Oxygenases; NAD; Organ Specificity; Rats; Rats, Inbred Strains; Species Specificity; Tryptophan; Tryptophan Oxygenase | 1991 |
Kynurenines in the regulation of behavior in insects.
Topics: Action Potentials; Animal Communication; Animals; Bees; Behavior, Animal; Calmodulin; Drosophila melanogaster; Eye Color; Genes; Genotype; Insecta; Kynurenic Acid; Kynurenine; Learning; Phenothiazines; Stimulation, Chemical; Structure-Activity Relationship; Tryptophan; Xanthurenates | 1991 |
Induction of indoleamine 2,3-dioxygenase in tumor cells transplanted into allogeneic mouse: interferon-gamma is the inducer.
Topics: Animals; Enzyme Induction; Graft Rejection; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mice; Neoplasm Transplantation; Sarcoma, Experimental; Transplantation, Homologous; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 1991 |
Tryptophan metabolism in senile cataract patients assessed by high-performance liquid chromatography.
Topics: Aging; Cataract; Chromatography, High Pressure Liquid; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 1991 |
Evidence for the preferential production of 3-hydroxyanthranilic acid from anthranilic acid in the rat brain.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Kynurenine; Male; Mixed Function Oxygenases; Organ Specificity; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Tryptophan | 1991 |
On kynureninase activity.
Topics: Animals; Apoenzymes; Benzothiazoles; Cysteine; Dithionitrobenzoic Acid; Dithiothreitol; Enzyme Activation; Hydrolases; Kynurenine; Liver; Magnesium; Male; Phenylpyruvic Acids; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine; Xanthurenates | 1991 |
Rat skin tryptophan 2,3-dioxygenase.
Topics: Animals; Hair; Kynurenine; Liver; Rats; Skin; Tryptophan; Tryptophan Oxygenase | 1991 |
Kynurenine and mesangial-proliferative glomerulonephritis.
Topics: Animals; Fasting; Glomerulonephritis, Membranoproliferative; Glomerulonephritis, Membranous; Humans; Hydrolases; Isoniazid; Kynurenine; Male; Rats; Rats, Inbred Strains; Tryptophan; Vitamin B 6 Deficiency | 1991 |
Impairment of kynurenine metabolism in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiomyopathies; Cells, Cultured; Humans; Hypertension; Isoniazid; Kynurenine; Myocardium; Niacin; Rats; Rats, Inbred Strains; Tryptophan; Vasoconstriction; Vitamin B 6 Deficiency; Water-Electrolyte Imbalance | 1991 |
Stable isotope-labeled tryptophan as a precursor for studying the disposition of quinolinic acid in rabbits.
Topics: Animals; Deuterium; Half-Life; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rabbits; Tissue Distribution; Tryptophan | 1991 |
Inhibition of tryptophan----niacin metabolism by dietary leucine and by leucine and 2-oxo-isocaproate in vitro.
Topics: Animals; Cells, Cultured; Depression, Chemical; Dietary Proteins; Keto Acids; Kynurenine; Leucine; Liver; NADP; Niacin; Niacinamide; Pellagra; Rats; Tryptophan; Xanthurenates | 1991 |
Indolic and kynurenine pathway metabolites of tryptophan in rat brain: effect of precursor availability on in vivo release.
Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Indoles; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1991 |
Tryptophan and its metabolite concentrations in human plasma and breast milk during the perinatal period.
Topics: Chromatography, High Pressure Liquid; Female; Fetal Blood; Humans; Infant, Newborn; Kynurenine; Labor, Obstetric; Milk, Human; Pregnancy; Tryptophan; Umbilical Arteries; Umbilical Veins | 1991 |
Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection.
Topics: Adult; Biopterins; Chromatography, High Pressure Liquid; Female; HIV Infections; HIV Seropositivity; HIV-1; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Neopterin; Radioimmunoassay; Tryptophan | 1991 |
Metabolism of tryptophan to niacin in Saccharomyces uvarum.
Topics: Carbon Radioisotopes; Kynurenine; Niacin; Saccharomyces; Transaminases; Tryptophan | 1991 |
Effects of exogenous hemin on the niacin content of aerobically grown Saccharomyces uvarum.
Topics: Aerobiosis; Glucose; Hemin; Kinetics; Kynurenine; Niacin; Saccharomyces; Tryptophan | 1991 |
Simultaneous measurements of tryptophan and its metabolites, kynurenine and serotonin, in the superficial layers of the spinal dorsal horn. A study in normal and arthritic rats.
Topics: Animals; Arthritis; Kynurenine; Lumbosacral Region; Rats; Reference Values; Serotonin; Spinal Cord; Tryptophan | 1990 |
Effect of ethanol ingestion on tryptophan metabolism in streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Ethanol; Kynurenine; Male; Rats; Rats, Inbred Strains; Tryptophan | 1990 |
Schistosoma mansoni: effects on tryptophan metabolism in mice.
Topics: Animals; Chemical Phenomena; Chemistry; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Niacinamide; Oxidation-Reduction; Pyridoxine; Schistosomiasis mansoni; Tryptophan | 1990 |
Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Cardiomegaly; Clonidine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Kynurenine; Male; Middle Aged; Nifedipine; Propranolol; Tryptophan | 1990 |
Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid.
Topics: Aged; Autopsy; Corpus Striatum; Female; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Male; Middle Aged; Putamen; Reference Values; Tryptophan; Tyrosine | 1990 |
Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biopterins; Dementia; Humans; Kynurenine; Male; Middle Aged; Neopterin; Peripheral Nervous System Diseases; Tryptophan | 1990 |
Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.
Topics: Aminooxyacetic Acid; Animals; Corpus Striatum; Extracellular Space; Kinetics; Kynurenic Acid; Kynurenine; Lyases; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Transaminases; Tryptophan | 1990 |
Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome.
Topics: Adult; Aged; Eosinophilia; Fasciitis; Female; Humans; Kynurenine; Middle Aged; Myositis; Prednisone; Scleroderma, Systemic; Skin; Syndrome; Tryptophan | 1990 |
[Tryptophan metabolism during the perinatal period].
Topics: Adult; Circadian Rhythm; Female; Humans; Infant, Newborn; Kynurenine; Labor, Obstetric; Pregnancy; Tryptophan; Umbilical Arteries; Umbilical Veins; Veins | 1990 |
The role of an invariant tryptophan residue in alpha-bungarotoxin and cobrotoxin. Investigation of active derivatives with the invariant tryptophan replaced by kynurenine.
Topics: Animals; Antibody Formation; Bungarotoxins; Circular Dichroism; Cobra Neurotoxin Proteins; Female; Kynurenine; Male; Mice; Precipitin Tests; Rabbits; Snakes; Spectrometry, Fluorescence; Tryptophan | 1990 |
L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Cortisone; Disease Models, Animal; Eosinophilia; Fasciitis; Female; Humans; Kynurenine; Muscular Diseases; Myositis; Nucleic Acid Hybridization; Rats; Rats, Inbred Lew; RNA, Messenger; Syndrome; Tryptophan | 1990 |
Tryptophan metabolic studies in patients with presenile cataracts.
Topics: Adolescent; Adult; Cataract; Female; Humans; Kynurenine; Male; Pyridoxine; Tryptophan; Xanthurenates | 1990 |
Uptake of kynurenine into rat brain slices.
Topics: Amino Acids; Animals; Biological Transport; Brain; Corpus Striatum; Ibotenic Acid; In Vitro Techniques; Kinetics; Kynurenine; Male; Organ Specificity; Rats; Rats, Inbred Strains; Sodium; Tryptophan | 1990 |
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
Topics: Animals; Antioxidants; Female; Free Radicals; Inflammation; Kinetics; Kynurenine; Liposomes; Lung; Mice; Mice, Inbred ICR; Orthomyxoviridae Infections; Peroxides; Tryptophan | 1990 |
Liquefaction of human vitreous in model aphakic eyes by 300-nm UV photolysis: monitoring liquefaction by fluorescence.
Topics: Aphakia, Postcataract; Circular Dichroism; Eye Proteins; Female; Humans; Kynurenine; Middle Aged; Spectrometry, Fluorescence; Tryptophan; Ultraviolet Rays; Viscosity; Vitreous Body | 1990 |
Disturbances in tryptophan metabolism in rats following chronic dietary aflatoxin treatment.
Topics: Aflatoxins; Animals; Bile Ducts; Brain Chemistry; Cell Division; Diet; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Male; Precancerous Conditions; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1985 |
Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.
Topics: Animals; Enzyme Induction; In Vitro Techniques; Interferons; Kinetics; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred ICR; Oxygenases; Tryptophan; Tryptophan Oxygenase | 1986 |
Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex.
Topics: Animals; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Kynurenine; Mice; Mice, Inbred C57BL; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Time Factors; Tryptophan | 1989 |
Characteristics of interferon induced tryptophan metabolism in human cells in vitro.
Topics: Cell Line; Chromatography, High Pressure Liquid; Enzyme Induction; HLA Antigens; HLA-DR Antigens; Humans; Interferon-gamma; Kynurenine; Macrophages; Oxygenases; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 1989 |
Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide.
Topics: Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Line; Cytoplasm; Free Radicals; Glutathione; Growth Inhibitors; Humans; Interferon-gamma; Kynurenine; Oxygen; Oxygen Consumption; Partial Pressure; Poly(ADP-ribose) Polymerase Inhibitors; Recombinant Proteins; Tryptophan; Tumor Cells, Cultured | 1989 |
Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells.
Topics: Animals; Caproates; In Vitro Techniques; Keto Acids; Kynurenine; Leucine; Liver; Male; NAD; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan; Xanthurenates | 1989 |
Increased brain 3-hydroxykynurenine in Huntington's disease.
Topics: Brain Chemistry; Cerebral Cortex; Humans; Huntington Disease; Kynurenine; Tryptophan | 1989 |
[Studies of tryptophan metabolism in cancer of the urinary bladder].
Topics: Humans; Kynurenine; Risk Factors; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1989 |
Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Male; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Transaminases; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1989 |
Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin 2.
Topics: Biopterins; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Interleukin-2; Kynurenine; Neoplasms; Neopterin; Recombinant Proteins; Tryptophan | 1989 |
Tryptophan 2,3-dioxygenase activity in rat skin.
Topics: Age Factors; Animals; Kynurenine; Liver; Male; Rats; Rats, Inbred Strains; Skin; Subcellular Fractions; Substrate Specificity; Tryptophan; Tryptophan Oxygenase | 1989 |
Kynurenine may directly interact with GABA receptors in rat brain.
Topics: Animals; Bicuculline; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Injections, Intraventricular; Kynurenine; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tryptophan | 1985 |
The correlation between certain tryptophan metabolites and the N-nitrosamine content in the urine of bilharzial bladder cancer patients.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aminohippuric Acids; Colorimetry; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrosamines; ortho-Aminobenzoates; Schistosomiasis haematobia; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1986 |
Preliminary brain autopsy findings in progredient Rett syndrome.
Topics: Amino Acids; Brain; Brain Chemistry; Child; Female; Ferritins; Humans; Intellectual Disability; Kynurenine; Movement Disorders; Receptors, Dopamine; Serotonin; Syndrome; Tryptophan | 1986 |
Gamma-interferon-induced inhibition of the growth of Rickettsia prowazekii in fibroblasts cannot be explained by the degradation of tryptophan or other amino acids.
Topics: Amino Acids; Animals; Fibroblasts; Humans; Interferon-gamma; Kynurenine; L Cells; Mice; Oxygenases; Recombinant Proteins; Rickettsia Infections; Rickettsia prowazekii; Tryptophan; Tryptophan Oxygenase | 1986 |
Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells.
Topics: Biological Transport; Chlamydophila psittaci; Humans; Interferon-gamma; Kynurenine; Tryptophan | 1986 |
Interferon-gamma suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan.
Topics: Animals; Cells, Cultured; Fibroblasts; Humans; Interferon-gamma; Kynurenine; Recombinant Proteins; Toxoplasma; Tryptophan | 1986 |
Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity.
Topics: Carcinoma; Cells, Cultured; Fibroblasts; Humans; Interferon beta-1a; Interferon beta-1b; Interferon Type I; Interferon-beta; Interferon-gamma; Kynurenine; Neoplasms; Recombinant Proteins; Stimulation, Chemical; Tryptophan; Urinary Bladder Neoplasms | 1986 |
The actions of interferon and antiinflammatory agents of induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Enzyme Induction; Humans; Interferon Type I; Interferon-gamma; Kinetics; Kynurenine; Monocytes; Oxygenases; Tryptophan; Tryptophan Oxygenase | 1987 |
Interferon-gamma-induced degradation of tryptophan by human cells in vitro.
Topics: Biopterins; Cells, Cultured; Chromatography, High Pressure Liquid; Fibroblasts; HeLa Cells; Humans; Indicators and Reagents; Interferon-gamma; Kynurenine; Neopterin; ortho-Aminobenzoates; Tryptophan | 1987 |
Tryptophan degradation in patients infected by human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biopterins; Humans; Kynurenine; Male; Neopterin; Reference Values; Retrospective Studies; Tryptophan | 1988 |
[Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Epilepsy; Female; Humans; Kynurenine; Male; Pneumonia; Spectrophotometry; Tryptophan | 1988 |
Increase in tryptophan oxygenase activity in alcoholic patients.
Topics: Adult; Alcoholism; Humans; Hydrocortisone; Kinetics; Kynurenine; Liver Function Tests; Male; Middle Aged; Protein Binding; Tryptophan; Tryptophan Oxygenase | 1988 |
Altered conversion of tryptophan to kynurenine in newly abstinent alcoholics.
Topics: Adult; Alcoholism; Humans; Kynurenine; Liver; Male; Serotonin; Tryptophan; Tryptophan Oxygenase | 1988 |
[Peculiarities of nicotinic acid formation in coronary heart disease with special reference to heart arrhythmias].
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Coronary Disease; Female; Humans; Kynurenine; Lipid Metabolism; Male; Microscopy, Electron; Middle Aged; Myocardial Infarction; Myocardium; Niacin; Pyridoxal Phosphate; Ranidae; Rats; Rats, Inbred Strains; Tryptophan | 1988 |
Fluorescence spectra of NADH/NAD, kynurenine, tryptophan, and tyrosine.
Topics: Kynurenine; NAD; Oxidation-Reduction; Oxidoreductases; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 1988 |
Tryptophan metabolism in women with breast cancer.
Topics: Breast Neoplasms; Female; Humans; Kynurenine; Receptors, Estrogen; Receptors, Progesterone; Tryptophan | 1988 |
Tryptophan 2,3-dioxygenase in chick embryo hepatocytes: studies in ovo and in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Glutethimide; Heme; Hydrogen-Ion Concentration; Kinetics; Kynurenine; Liver; Male; Methemoglobin; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1988 |
Comparative studies on the status of invariant tryptophan residue in alpha-bungarotoxin and cobrotoxin.
Topics: Bungarotoxins; Cobra Neurotoxin Proteins; Drug Residues; Elapid Venoms; Kynurenine; Structure-Activity Relationship; Tryptophan | 1986 |
High-voltage electrophoretic separation of tryptophan metabolites of the kynurenine pathway.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Electrophoresis; Kynurenine; Male; Rats; Rats, Inbred Strains; Solvents; Spectrophotometry, Ultraviolet; Tryptophan | 1987 |
3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets.
Topics: 3-Hydroxyanthranilic Acid; Aminophenols; Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kynurenine; Leucine; Male; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tryptophan | 1985 |
Effect of scalding on tryptophan catabolism in rats.
Topics: Animals; Burns; Kynurenine; Male; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1985 |
Reactions of oxy- and methemoglobin with tryptophan metabolites, 3-hydroxyanthranilic acid and 3-hydroxykynurenine.
Topics: 3-Hydroxyanthranilic Acid; Humans; Kinetics; Kynurenine; Methemoglobin; ortho-Aminobenzoates; Oxidation-Reduction; Oxyhemoglobins; Phytic Acid; Protein Binding; Spectrophotometry; Structure-Activity Relationship; Tryptophan | 1986 |
The photolysis of lens fiber membranes.
Topics: Amino Acids; Animals; Aquaporins; Cattle; Electrophoresis, Polyacrylamide Gel; Eye Proteins; Glutathione; Histidine; In Vitro Techniques; Kynurenine; Lens Cortex, Crystalline; Lens, Crystalline; Membrane Glycoproteins; Photolysis; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan | 1985 |
Breakfast meal composition influences plasma tryptophan to large neutral amino acid ratios of healthy lean young men.
Topics: Adult; Amino Acids; Brain; Diet; Dietary Carbohydrates; Dietary Proteins; Humans; Kynurenine; Male; Middle Aged; Serotonin; Time Factors; Tryptophan | 1985 |
Effects of tryptophan metabolites on enzymes of oxidative phosphorylation.
Topics: Acetoacetates; Adenine Nucleotides; Amino Acids; Animals; Antimycin A; Cyanides; Cytochromes; Depression, Chemical; Dicumarol; Hydroxybutyrates; In Vitro Techniques; Ketoglutaric Acids; Kynurenic Acid; Kynurenine; Liver; Manometry; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; NAD; Nitriles; ortho-Aminobenzoates; Oxidative Phosphorylation; Oxygen Consumption; Phenylbutyrates; Phenylhydrazines; Polarography; Rats; Rotenone; Spectrophotometry; Stimulation, Chemical; Temperature; Tryptophan; Uncoupling Agents; Xanthurenates | 1971 |
[Chromatographic separation of tryptophan metabolites on thin-layer silica gel].
Topics: Adolescent; Child; Chromatography, Thin Layer; Diabetes Mellitus; Gels; Humans; Indoleacetic Acids; Kynurenine; Methods; ortho-Aminobenzoates; Silicon Dioxide; Tryptamines; Tryptophan | 1971 |
The effect of tryptophan load and vitamin B 6 supplementation on urinary excretion of tryptophan metabolites in human male subjects.
Topics: Aminohippuric Acids; Glucuronates; Humans; Kynurenine; Male; ortho-Aminobenzoates; Prostatic Hyperplasia; Prostatic Neoplasms; Pyridoxine; Tryptophan; Urinary Bladder Neoplasms | 1971 |
End-product regulation of the tryptophan-nicotinic acid pathway in Neurospora crassa.
Topics: Arylformamidase; Cell-Free System; Culture Media; Fluorometry; Hydrolases; Kynurenine; Neurospora; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Spectrophotometry; Spores, Fungal; Tryptophan; Tryptophan Oxygenase | 1971 |
Regulation of the synthesis of enzymes of tryptophan dissimilation in Acinetobacter calcoaceticus.
Topics: Arylformamidase; Bacteria; Enzyme Induction; Enzymes; Hydrolases; Kynurenine; Oxygen Consumption; Tryptophan; Tryptophan Oxygenase | 1972 |
Improved biochemical preparation of L-kynurenine.
Topics: Animals; Arylformamidase; Chromatography, Paper; In Vitro Techniques; Kynurenine; Liver; Pseudomonas; Rats; Tryptophan; Tryptophan Oxygenase | 1974 |
Multicentric and multifocal urothelial tumors.
Topics: Acetophenones; Aged; Aniline Compounds; Carcinogens; Glucuronidase; Humans; Hydronephrosis; Kynurenine; Male; ortho-Aminobenzoates; Phenols; Prostatectomy; Prostatic Hyperplasia; Tryptophan; Ureteral Neoplasms; Urinary Bladder Neoplasms | 1974 |
Aromatic amino acid transaminases in rat brain.
Topics: 5-Hydroxytryptophan; Ammonium Sulfate; Animals; Brain; Chemical Precipitation; Chromatography, DEAE-Cellulose; Dihydroxyphenylalanine; Ketoglutaric Acids; Kynurenine; Male; Oxaloacetates; Phenylalanine; Pyruvates; Rats; Transaminases; Tryptophan; Tyrosine Transaminase | 1973 |
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.
Topics: Animals; Depression, Chemical; Ethanol; Humans; Hydrocortisone; Injections, Intraperitoneal; Kynurenine; Liver; NAD; NADP; Phenobarbital; Rats; Sodium Chloride; Sodium Salicylate; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
Aromatic amino acid transaminase in rat intestine.
Topics: 5-Hydroxytryptophan; Animals; Chemical Phenomena; Chemistry, Physical; Chromatography, DEAE-Cellulose; Chromatography, Gel; Intestine, Small; Ketoglutaric Acids; Kinetics; Kynurenine; Male; Oxaloacetates; Phenylalanine; Pyruvates; Rats; Transaminases; Tryptophan; Tyrosine Transaminase | 1973 |
[Studies on tryptophan metabolism in oligophrenic children. 2. Vitamin-dependent enzyme patterns (B1, B2, B6) and excretion of the tryptophan metabolites kynurenin, xanthurenic acid, trigonellinamide, and N-methylpyridone].
Topics: Child; Female; Humans; Hydrolases; Intellectual Disability; Kynurenine; Liver; Male; NADP; Pyridoxine; Riboflavin; Thiamine; Tryptophan; Xanthurenates | 1974 |
Effect of endotoxin on metabolic regulation in mice.
Topics: Animals; Carbon Radioisotopes; Cortisone; Cyproheptadine; Drug Antagonism; Endotoxins; Energy Metabolism; Enzyme Induction; Injections, Intraperitoneal; Injections, Intravenous; Kynurenine; Lethal Dose 50; Leucine; Liver; Mice; NAD; NADP; Orotic Acid; Protein Biosynthesis; RNA; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase | 1973 |
Actinomycin synthesis in washed cells of Streptomyces antibioticus.
Topics: Chloramphenicol; Dactinomycin; In Vitro Techniques; Kynurenine; ortho-Aminobenzoates; Streptomyces; Tryptophan; Valine | 1965 |
Tryptophan metabolism in carcinoma of the breast.
Topics: Adult; Aged; Breast Neoplasms; Chromatography, Thin Layer; Estrogens; Female; Humans; Kynurenine; Middle Aged; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1967 |
Characterization of enzymes hydrolyzing acylnaphthylamides. 3. Role of kynurenine formamidase.
Topics: Amides; Aminohydrolases; Animals; Arylformamidase; Chemistry Techniques, Analytical; Chromatography, Gel; Guinea Pigs; Histocytochemistry; Kynurenine; Liver; Naphthalenes; Tryptophan | 1966 |
Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.
Topics: Adrenal Cortex Hormones; Animals; Antidepressive Agents; Brain; Brain Chemistry; Depression; Drug Synergism; Electroshock; Humans; Imipramine; Kynurenine; Liver; Monoamine Oxidase Inhibitors; Serotonin; Serotonin Antagonists; Tranquilizing Agents; Tryptophan; Tryptophan Oxygenase | 1969 |
Changes resembling lupus erythematosus after prolonged treatment with Ro-4-4602, a potent inhibitor of 5-HTP-carboxyliase, in white rats.
Topics: 5-Hydroxytryptophan; Aminobenzoates; Animals; Carboxy-Lyases; Cholesterol; Creatinine; Female; Hydrazines; Hydroxyindoleacetic Acid; Kidney; Kynurenine; Liver; Lupus Erythematosus, Systemic; Male; Neutrophils; Proline; Rats; Spleen; Tryptophan; Vanilmandelic Acid | 1969 |
Stimulatin of tryptophan metabolism in the rat by 4-dimethylamino-3'methylazobenzene and 2-acetamidofluorene.
Topics: Animals; Carcinogens; Enzyme Induction; Fluorenes; Kynurenine; Liver; p-Dimethylaminoazobenzene; Rats; Tryptophan; Tryptophan Oxygenase | 1972 |
Chemical modification of the tryptophan residue in toxin B from the venom of the Indian cobra.
Topics: Amino Acids; Animals; Biological Assay; Chromatography, Gel; Immunodiffusion; Kynurenine; Lethal Dose 50; Mice; Nitrobenzenes; Ozone; Precipitin Tests; Snakes; Spectrophotometry, Ultraviolet; Sulfenic Acids; Time Factors; Toxins, Biological; Tryptophan; Venoms | 1974 |
Vitamin B6 metabolism in women using oral contraceptives.
Topics: Adult; Biological Assay; Contraceptives, Oral; Creatinine; Drug Combinations; Ethynodiol Diacetate; Female; Humans; Isonicotinic Acids; Kynurenine; Lacticaseibacillus casei; Menstruation; Mestranol; Norethindrone; Pyridoxine; Saccharomyces; Streptococcus; Time Factors; Tryptophan | 1974 |
Effects of L-tryptophan load on the metabolism of tryptophan-2-C14 in man.
Topics: Aged; Aminohippuric Acids; Carbon Dioxide; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Niacinamide; Pyridines; Pyridones; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1967 |
Tryptophan load and uptake of tryptophan by leukocytes in Hartnup disease.
Topics: Adolescent; Amino Acids; Chromatography, Paper; Female; Hartnup Disease; Humans; Indoleacetic Acids; Kynurenine; Leukocytes; Male; Niacinamide; Tryptophan | 1966 |
[Elimination of the metabolites of the tryptophan--nicotinic acid pathway after corticoid treatment in the rat].
Topics: Adrenal Cortex Hormones; Animals; Hippurates; Hydrocortisone; Kynurenine; Niacinamide; Nicotinic Acids; Rats; Tryptophan; Xanthurenates | 1967 |
[Studies on the L-tryptophan metabolism in children with Down's syndrome].
Topics: Child; Child, Preschool; Chromatography; Down Syndrome; Female; Humans; Infant; Kynurenine; Male; Mosaicism; Spectrophotometry; Trisomy; Tryptophan; Xanthurenates | 1968 |
Tryptophan metabolism in humans with various types of anemias.
Topics: Adult; Aged; Anemia; Carbon Dioxide; Carbon Isotopes; Child; Female; Humans; Kynurenine; Male; Middle Aged; Niacinamide; ortho-Aminobenzoates; Pyridines; Pyridones; Pyridoxine; Spirometry; Thalassemia; Tryptophan; Tryptophan Oxygenase | 1968 |
Comparative tryptophan metabolism in cats and rats: differences in adaptation of tryptophan oxygenase and in vivo metabolism of tryptophan, kynurenine and hydroxykynurenine.
Topics: Amino Acids; Aminohippuric Acids; Animals; Cats; Enzyme Induction; Glucuronates; Hydrocortisone; Indican; Kynurenic Acid; Kynurenine; Male; Niacinamide; ortho-Aminobenzoates; Phenylbutyrates; Rats; Species Specificity; Sulfates; Tryptophan; Tryptophan Oxygenase; Urinary Bladder Neoplasms; Xanthurenates | 1969 |
The metabolism of vitamin B6 in Down's syndrome.
Topics: Adolescent; Down Syndrome; Humans; Kynurenine; Male; Oxalates; Pyridoxine; Taurine; Tryptophan; Xanthurenates | 1969 |
Tryptophan metabolism as affected by anovulatory agents.
Topics: Aminohippuric Acids; Chlorotrianisene; Diethylstilbestrol; Estrogens; Female; Humans; Isoniazid; Kynurenine; Male; Menstruation; Mestranol; Niacinamide; Nicotinic Acids; Norethynodrel; Ovulation; Pregnancy; Progesterone; Pyridoxine; Scleroderma, Systemic; Tryptophan; Urinary Bladder Neoplasms; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
[Observations on tryptophan-nicotinic acid metabolism after a load of tryptophan and lysine in rats with pyridoxine deficiency].
Topics: Animals; Chromatography; Kynurenine; Lysine; Niacinamide; Nicotinic Acids; Rats; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
[Tryptophan metabolism in bladder carcinoma].
Topics: Aged; Animals; Autoradiography; Carcinoma; Chromatography; Humans; Kynurenic Acid; Kynurenine; Middle Aged; ortho-Aminobenzoates; Papilloma; Rats; Tritium; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1970 |
Lack of effect of smoking on the excretion of tryptophan metabolites by man.
Topics: Adult; Aminohippuric Acids; Female; Glucuronates; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Niacinamide; Pyridinium Compounds; Smoking; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1970 |
A disorder of tryptophan metabolism in chronic granulomatous disease.
Topics: Child; Child, Preschool; Chromatography, Paper; Chronic Disease; Granuloma; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infections; Kynurenic Acid; Kynurenine; Lymphadenitis; Male; Niacinamide; Pyridoxine; Tryptophan; Xanthurenates | 1970 |
The influence of nicotinamide on the urinary excretion of tryptophan metabolites in Hodgkin's disease.
Topics: Adolescent; Adult; Amino Acids; Female; Hodgkin Disease; Humans; Kynurenine; Male; Metabolism; Middle Aged; Niacinamide; ortho-Aminobenzoates; Phenylbutyrates; Pyridoxine; Tryptophan; Xanthurenates | 1970 |
Tryptophan metabolism in the cat: a study with carbon-14-labeled compounds.
Topics: Aminohippuric Acids; Animals; Carbon Dioxide; Carbon Isotopes; Cat Diseases; Cats; Kynurenine; Male; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Picolinic Acids; Pyridines; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1971 |
[Tryptophan metabolism in patients with pellagra].
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Child, Preschool; Female; Hartnup Disease; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Middle Aged; Niacinamide; Pellagra; Tryptamines; Tryptophan | 1970 |
Tryptophan metabolism in patients with pellagra: problem of vitamin B 6 enzyme activity and feedback control of tryptophan pyrrolase enzyme.
Topics: Black or African American; Black People; Feedback; Female; Humans; Kynurenine; Male; Niacinamide; Nicotinic Acids; Pellagra; Pyridines; Pyridones; Pyridoxine; South Africa; Tryptophan; Tryptophan Oxygenase; United States; White People; Xanthurenates | 1971 |
The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism.
Topics: Alanine; Allopurinol; Amino Acids; Animals; Brain; Brain Chemistry; Carbon Isotopes; Carboxy-Lyases; Histamine; Kynurenic Acid; Kynurenine; Male; Methanol; Methyldopa; Mixed Function Oxygenases; Niacinamide; Nicotinic Acids; Nitroglycerin; ortho-Aminobenzoates; Phenylalanine; Phenylbutyrates; Picolinic Acids; Pyridines; Pyridoxal Phosphate; Pyridoxine; Rats; Serotonin; Sulfuric Acids; Time Factors; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1970 |
Conversion of D-tryptophan to nicotinic acid in the rat.
Topics: Animals; Deficiency Diseases; Indoles; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyruvates; Rats; Stereoisomerism; Sulfuric Acids; Tryptophan; Xanthurenates | 1971 |
[Absence of change in urinary levels of metabolites of tryptophan and tobacco].
Topics: Adult; Female; Humans; Kynurenine; Male; Niacinamide; Nicotiana; ortho-Aminobenzoates; Phenols; Plants, Toxic; Smoking; Tryptophan | 1971 |
The influence of simultaneous administration of vitamin B 6 and nicotinamide on tryptophan metabolism in Hodgkin's disease.
Topics: Acylation; Administration, Oral; Aminohippuric Acids; Hodgkin Disease; Humans; Hydroxylation; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Methyl Ethers; Niacinamide; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Xanthurenates | 1972 |
[Biosynthesis of nicotinic acid in Rhodotorula glutinis].
Topics: Kynurenine; Mitosporic Fungi; Mutation; Neurospora; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Radiation Genetics; Tryptophan; Ultraviolet Rays | 1972 |
[Functional exploration at various levels of the tryptophan--nicotinic acid metabolic line].
Topics: Diabetes Mellitus; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Oxidation-Reduction; Pregnancy; Serotonin; Tryptophan; Vitamin B 6 Deficiency | 1972 |
Distinct kynureninase and hydroxykynureninase activities in microorganisms: occurrence and properties of a single physiologically discrete enzyme in yeast.
Topics: Aerobiosis; Anaerobiosis; Cell-Free System; Chemical Precipitation; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Culture Media; Fluorometry; Hydrolases; Hydroxylation; Kynurenine; Neurospora crassa; ortho-Aminobenzoates; Saccharomyces cerevisiae; Stereoisomerism; Tryptophan | 1973 |
Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma).
Topics: Arthritis, Rheumatoid; Aspirin; Cystinuria; Drug Synergism; Edetic Acid; Humans; Kynurenic Acid; Kynurenine; Methods; Niacinamide; Penicillamine; Pyridoxine; Scleroderma, Systemic; Tryptophan; Xanthurenates | 1973 |
Tryptophan metabolism and kynureninase induction in mutants of Neurospora crassa resistant to 4-methyl-tryptophan.
Topics: Biological Transport, Active; Carbon Isotopes; Cell-Free System; Drug Resistance, Microbial; Enzyme Induction; Hydrolases; Indoles; Kynurenine; Methylation; Mutation; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Tryptophan | 1973 |
Isolation and characterization of low-kynureninase mutants of Neurospora crassa.
Topics: Chromatography, DEAE-Cellulose; Enzyme Induction; Genes, Regulator; Hydrolases; Kynurenine; Mitochondria; Molecular Weight; Mutagens; Mutation; Neurospora; Neurospora crassa; Nitrosoguanidines; Stereoisomerism; Tryptophan | 1974 |
Occurrence of N-formylkynurenine in extracts of Neurospora crassa: evidence for the activity of tryptophan pyrrolase.
Topics: Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; Chromatography, Thin Layer; Culture Media; Filtration; Formates; Kynurenic Acid; Kynurenine; Neurospora; Neurospora crassa; ortho-Aminobenzoates; Spectrometry, Fluorescence; Stereoisomerism; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1974 |
The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway.
Topics: Adolescent; Adult; Aged; Androgens; Animals; Estrogens; Female; Humans; Hydrocortisone; Hydrolases; Indican; Isoniazid; Kynurenine; Male; Menstruation; Middle Aged; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pregnancy; Pyridones; Pyridoxine; Rats; Transaminases; Tryptophan | 1974 |
[Proceedings: Tryptophan metabolism, bladder carcinoma and smoking habits].
Topics: 3-Hydroxyanthranilic Acid; Carcinoma; Humans; Kynurenine; Niacinamide; Smoking; Tryptophan; Urinary Bladder Neoplasms | 1972 |
ACTH induced changes in tryptophan turnover along induceable pathways in man.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Carbon Isotopes; Glycine; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Male; Tryptophan | 1966 |
Enzymic formation of D-kynurenine from D-tryptophan.
Topics: Adenine Nucleotides; Animals; Hydrogen Peroxide; Ileum; In Vitro Techniques; Intestine, Small; Kynurenine; Methylene Blue; NAD; Nucleosides; Oxygen Consumption; Oxygenases; Rabbits; Tryptophan; Tryptophan Oxygenase | 1967 |
[Influence of ACTH on the tryptophan--nicotinic acid pathway in normal subjects and those with rheumatoid arthritis].
Topics: Adrenocorticotropic Hormone; Adult; Arthritis, Rheumatoid; Humans; Kynurenine; Middle Aged; Nicotinic Acids; Pyridones; Tryptophan | 1967 |
The influence of adrenocortical hormones and vitamins upon tryptophan metabolism in man.
Topics: Adrenocorticotropic Hormone; Adult; Benzoates; Breast Neoplasms; Female; Humans; Hydrocortisone; Kynurenine; Liver; Male; Niacinamide; Pyridoxine; Riboflavin; Stimulation, Chemical; Stress, Physiological; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1968 |
Studies with tryptophan metabolites in vitro. 3. The effect of schistosomicidal drugs on kynureninase and kynurenine transaminase of normal mouse liver.
Topics: Animals; Anti-Infective Agents; Antimony; Benzenesulfonates; Calcium; Imidazoles; In Vitro Techniques; Kynurenic Acid; Kynurenine; Liver; Magnesium; Mice; ortho-Aminobenzoates; Pyridoxal Phosphate; Tartrates; Transaminases; Tryptophan | 1969 |
Effect of treatment on tryptophan metabolism in childhood epilepsy.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Central Nervous System Diseases; Child; Child, Preschool; Epilepsy; Humans; Infant; Kynurenine; Pyridoxine; Spasm; Steroids; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
Regulation of enzymes involved in the conversion of tryptophan to nicotinamide adenine dinucleotide in a colorless strain of Xanthomonas pruni.
Topics: Amidohydrolases; Enzyme Induction; Hydrolases; Kynurenine; Mutation; NAD; ortho-Aminobenzoates; Oxygenases; Tryptophan; Tryptophan Oxygenase; Xanthomonas | 1970 |
Effects of steroid conjugates on availability of pyridoxal phosphate for kynureninase and kynurenine aminotransferase activity.
Topics: Animals; Binding Sites; Body Weight; Castration; Depression, Chemical; Diet; Diethylstilbestrol; Estrogens, Conjugated (USP); Female; Hydrolases; Kidney; Kynurenine; Liver; Male; Mitochondria; Mitochondria, Liver; Organ Size; Ovary; Protein Binding; Pyridoxal Phosphate; Rats; Sex Factors; Transaminases; Tryptophan | 1971 |
Studies on tryptophan metabolism in male subjects treated with hydrocortisone.
Topics: Chromatography, Ion Exchange; Humans; Hydrocortisone; Kynurenic Acid; Kynurenine; Male; NAD; Pyridoxine; Statistics as Topic; Tryptophan | 1971 |
Evidence for distinct kynureninase and hydroxykynureninase activities in Neurospora crassa.
Topics: Cell-Free System; Chromatography, DEAE-Cellulose; Culture Media; Enzyme Induction; Fluorometry; Hydrolases; Kynurenine; Magnesium Sulfate; Models, Chemical; NAD; Neurospora; ortho-Aminobenzoates; Pyridoxal Phosphate; Tryptophan | 1971 |
Abnormal tryptophan metabolism in patients with scurvy-type skin.
Topics: Acetates; Adult; Aminohippuric Acids; Black or African American; Black People; Ethnicity; Glucuronates; Hemosiderosis; Humans; Indoles; Kynurenic Acid; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Scurvy; South Africa; Sulfuric Acids; Tryptophan; Xanthurenates | 1973 |
Metabolism of pyridine nucleotides and its relation to DNA synthesis in regenerating mouse liver.
Topics: Adenine Nucleotides; Animals; DNA; Female; Hepatectomy; Hydrolases; Kynurenine; Liver; Liver Regeneration; Mice; Mice, Inbred Strains; NAD; Niacinamide; Nicotinamide Mononucleotide; Nucleotidyltransferases; ortho-Aminobenzoates; Pentosyltransferases; Transaminases; Tryptophan | 1972 |
[Proceedings: NAD biosynthesis from tryptophan in mouse liver].
Topics: Animals; DNA; Hydrolases; Kynurenine; Liver; Liver Regeneration; Mice; NAD; Niacinamide; Nicotinic Acids; Thymidine; Tryptophan | 1972 |
[On the biosynthesis of 2,3-dihydroxybenzoic acid in submersion cultures of Claviceps paspali Stevens et Hall].
Topics: Ascomycota; Benzoates; Culture Media; In Vitro Techniques; Kynurenine; ortho-Aminobenzoates; Tryptophan | 1965 |
[Changes in the hemolymph prior to pupa formation in Cerura vinula L.: the content in protein, amino acids ommochrome precursors and ommochromes].
Topics: Amino Acids; Animals; Carbohydrates; Chromatography, Ion Exchange; Hemolymph; Insecta; Kynurenine; Metamorphosis, Biological; Oxygen Consumption; Pigments, Biological; Proteins; Tryptophan | 1966 |
[Fluorescing substances from the Malpighian tubules of wild-type and various eye color mutants of Drosophila melanogaster].
Topics: Animals; Chromatography, Paper; Drosophila; Eye; Fluorescence; Kynurenic Acid; Kynurenine; Malpighian Tubules; Molecular Biology; Mutation; Pigments, Biological; Pteridines; Riboflavin; Spectrophotometry; Tryptophan; Xanthurenates | 1968 |
[Quantitative studies on ommochrome precursors in the Malpighian tubules of different Drosophila mutants].
Topics: Animals; Chromatography, Paper; Drosophila; Kynurenine; Malpighian Tubules; Mixed Function Oxygenases; Molecular Biology; Mutation; Pigments, Biological; Spectrophotometry; Tryptophan | 1968 |
The functional significance of changes in activity of the enzymes, tryptophan pyrrolase and tyrosine transaminase, after induction in intact rats and in the isolated, perfused rat liver.
Topics: Adrenal Glands; Adrenalectomy; Animals; Carbon Dioxide; Carbon Isotopes; Enzyme Induction; Hydrocortisone; In Vitro Techniques; Kynurenine; Liver; Male; Perfusion; Rats; Stimulation, Chemical; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase | 1969 |
[On the occurrence of pterins, tryptophan and its derivatives in various organs of the white mutant of Drosophila melanogaster].
Topics: Adipose Tissue; Animals; Chromatography, Paper; Drosophila; Feces; Female; Kynurenine; Male; Malpighian Tubules; Meconium; Molecular Biology; Mutation; Ovary; Pterins; Testis; Tryptophan | 1969 |
The effect of sodium salicylate on the binding of L-tryptophan to serum proteins.
Topics: Amino Acids; Blood Proteins; Dialysis; Humans; In Vitro Techniques; Kynurenine; ortho-Aminobenzoates; Protein Binding; Salicylates; Serum Albumin, Bovine; Tryptophan | 1969 |
Effects of steroid and nonsteroid metabolites on enzyme conformation and pyridoxal phosphate binding.
Topics: Animals; Buffers; Castration; Diethylstilbestrol; Estrogens; Female; In Vitro Techniques; Kidney; Kynurenine; Liver; Male; Mitochondria, Liver; Ovary; Protein Binding; Pyridoxal Phosphate; Rats; Steroids; Transaminases; Transferases; Tryptophan; Tyrosine Transaminase; Vitamin B 6 Deficiency | 1969 |
Production of D-kynurenine and other metabolites from D-tryptophan by the intact rabbit and by rabbit tissue.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chromatography, Ion Exchange; Chromatography, Paper; Colorimetry; D-Amino-Acid Oxidase; Deamination; In Vitro Techniques; Indoles; Intestine, Small; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Pyruvates; Rabbits; Spectrophotometry; Spectrum Analysis; Tryptophan; Tryptophan Oxygenase | 1971 |
Studies of tryptophan metabolism in experimental animals and man during infectious illness.
Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Aminohippuric Acids; Animals; Azo Compounds; Carbon Isotopes; Circadian Rhythm; Fasting; Glucocorticoids; Humans; Indican; Kynurenic Acid; Kynurenine; Leucine; Liver; Mice; ortho-Aminobenzoates; Phenylbutyrates; Phlebotomus Fever; Pneumococcal Infections; Protein Biosynthesis; Rocky Mountain Spotted Fever; Salmonella Infections; Salmonella typhi; Streptococcus pneumoniae; Tryptophan; Tryptophan Oxygenase; Typhoid Fever; Xanthurenates | 1971 |
Inversion in the metabolism of D-tryptophan in the rabbit and the rat.
Topics: Aerobiosis; Amination; Anaerobiosis; Animals; Chromatography, Paper; D-Amino-Acid Oxidase; Deamination; Diet; Indoles; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Organ Specificity; ortho-Aminobenzoates; Oryza; Oxidation-Reduction; Oxygen Consumption; Pyridoxal Phosphate; Pyruvates; Rabbits; Rats; Species Specificity; Stereoisomerism; Tryptophan | 1971 |
[Changes in tryptophan metabolism in the hepatic tissue of mice after irradiation of the head and trunk].
Topics: Carboxy-Lyases; Dopa Decarboxylase; Head; Hydrolases; Kynurenine; Liver; Monoamine Oxidase; Radiation Effects; Radiometry; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase; Whole-Body Counting | 1971 |
Complexity of in vivo induction of tryptophan oxygenase and tyrosine aminotransferase: effects of tryptophan metabolites.
Topics: Animals; Carboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Hydrocortisone; Kynurenic Acid; Kynurenine; Liver; Male; ortho-Aminobenzoates; Picolinic Acids; Pyridines; Quinolines; Rats; Succinates; Theophylline; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase; Xanthurenates | 1972 |
Regulation of pyridine nucleotide levels and ratios in Neurospora crassa.
Topics: Culture Media; Genetics, Microbial; Glucosephosphate Dehydrogenase; Kynurenine; Mixed Function Oxygenases; Mutation; NAD; NADP; Neurospora; Neurospora crassa; Nicotinic Acids; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Tryptophan | 1972 |
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica.
Topics: Acrodermatitis; Adolescent; Amino Acid Metabolism, Inborn Errors; Aminohippuric Acids; Arachidonic Acids; Child; Child, Preschool; Fatty Acids; Female; Humans; Indoles; Kynurenic Acid; Kynurenine; Linoleic Acids; Malabsorption Syndromes; Male; ortho-Aminobenzoates; Paronychia; Pyridoxine; Quinolines; Tryptophan; Xanthurenates | 1974 |
[Catabolism of tryptophan by Candida guilliermondii, strain H17].
Topics: Alcohols; Biodegradation, Environmental; Candida; Cells, Cultured; Chromatography, Thin Layer; Culture Media; Deamination; Decarboxylation; Formamides; Glucose; Indoleacetic Acids; Indoles; Kynurenine; ortho-Aminobenzoates; Pyruvates; Time Factors; Tryptamines; Tryptophan | 1974 |
Studies with tryptophan metabolites in vitro. Effect of zinc, manganese, copper and cobalt ions on kynurenine hydrolase and kynurenine aminotransferase in normal mouse liver.
Topics: Animals; Cobalt; Copper; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolases; In Vitro Techniques; Kynurenine; Liver; Manganese; Mice; ortho-Aminobenzoates; Spectrophotometry, Ultraviolet; Transaminases; Tryptophan; Zinc | 1974 |
Tryptophan and methionine metabolism of adult females as affected by vitamin B-6 deficiency.
Topics: Adult; Body Weight; Cystathionine; Cysteine; Dietary Proteins; Female; Homocystine; Humans; Kynurenic Acid; Kynurenine; Methionine; Nutritional Physiological Phenomena; Pyridoxine; Sulfinic Acids; Taurine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1974 |
Urinary excretion of tryptophan metabolites during phototherapy.
Topics: Aminohippuric Acids; Humans; Hydroxyindoleacetic Acid; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Photochemistry; Phototherapy; Serotonin; Tryptophan; Xanthurenates | 1974 |
Microanalysis of tryptophan metabolites in mice.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Creatinine; Evaluation Studies as Topic; Female; Fluorescence; Glucuronates; Hydroxyindoleacetic Acid; Indicators and Reagents; Kynurenine; Methods; Mice; Microchemistry; Serotonin; Sulfuric Acids; Tryptophan | 1974 |
Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan.
Topics: Aging; Allopurinol; Animals; Apoproteins; Cycloheximide; Dactinomycin; Enzyme Induction; Enzyme Precursors; Guinea Pigs; Hydrocortisone; Injections, Intraperitoneal; Kynurenine; Liver; Male; Rats; Tryptophan; Tryptophan Oxygenase | 1974 |
Abnormalities of tryptophan metabolism (kynurenine pathway) found in a group of 830 mentally retarded children.
Topics: Child; Child, Preschool; Chromatography, Paper; Female; Humans; Infant; Infant, Newborn; Intellectual Disability; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Phenols; Pyridoxine; Spectrophotometry; Tryptophan; Xanthurenates | 1974 |
[Studies on tryptophan metabolism in oligophrenic children. 3. Activity capability of activation of hepatic kynureninase].
Topics: Adolescent; Adult; Child; Humans; Hydrolases; Intellectual Disability; Kynurenine; Liver; Tryptophan | 1974 |
Subcellular distribution and properties of kynurenine transaminase in rat liver.
Topics: Alcohol Oxidoreductases; Animals; Chromatography; Chromatography, DEAE-Cellulose; Hydrogen-Ion Concentration; Hydroxyapatites; Ketoglutaric Acids; Kynurenine; Liver; Mitochondria, Liver; Monoamine Oxidase; Pyruvates; Rats; Subcellular Fractions; Transaminases; Tryptophan | 1974 |
Tryptophan metabolism in burns.
Topics: Adolescent; Adult; Aminohippuric Acids; Burns; Child; Child, Preschool; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Skin; Tryptophan | 1974 |
Transamination of kynurenines.
Topics: Animals; Chickens; Grasshoppers; Horses; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Neurospora; Nicotinic Acids; Pyridoxine; Rats; Transaminases; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1974 |
Studies on the role of tryptophan metabolites in the genesis of bladder cancer.
Topics: Animals; Carbon Isotopes; Cholesterol; Feces; Female; Humans; Kynurenine; Mice; Mononuclear Phagocyte System; Neoplasms, Experimental; ortho-Aminobenzoates; Pharmaceutical Vehicles; Pulmonary Ventilation; Tablets; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xanthurenates | 1973 |
An improved column chromatographic method for isolation of tryptophan metabolites.
Topics: 5-Hydroxytryptophan; Aldehydes; Amides; Animals; Chromatography, DEAE-Cellulose; Colorimetry; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Male; Methods; Nitriles; Rats; Serotonin; Spectrometry, Fluorescence; Tryptamines; Tryptophan; Urea; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
Factors controlling the selection of tissue-specific metabolic pathways in early embryonic cells.
Topics: Animals; Anura; Carbon Isotopes; Cells, Cultured; Culture Media; Embryo, Nonmammalian; Female; Kynurenine; Melatonin; Methods; Protein Biosynthesis; Proteins; Rana pipiens; Serotonin; Time Factors; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase | 1973 |
Insulin-releasing effect of quinaldic acid and its relatives on isolated Langerhans islets.
Topics: Animals; Carboxylic Acids; Cells; Insulin; Insulin Secretion; Islets of Langerhans; Kynurenine; Male; Quinolines; Rats; Tryptophan; Xanthurenates | 1973 |
Tryptophan metabolism in acrodermatitis enteropathica.
Topics: Acrodermatitis; Aminohippuric Acids; Child; Child, Preschool; Creatinine; Female; Gastrointestinal Diseases; Humans; Iodoquinol; Kynurenic Acid; Kynurenine; Male; Mixed Function Oxygenases; Tryptophan; Xanthurenates | 1973 |
3-Hydroxy-4-methylkynurenine as an intermediate in actinomycin biosynthesis.
Topics: Carbon Radioisotopes; Dactinomycin; Kynurenine; Methionine; Streptomyces antibioticus; Tryptophan; Valine | 1973 |
Studies on tryptophan metabolism in patients with lymphoma.
Topics: Hodgkin Disease; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Liver; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1974 |
Computer simulation and analysis of tryptophan metabolism via kynurenine pathway in liver.
Topics: Coenzymes; Computers, Analog; Diagnosis, Computer-Assisted; Feedback; Humans; Kynurenic Acid; Kynurenine; Liver; Mathematics; Metabolic Diseases; Models, Biological; Nutrition Disorders; ortho-Aminobenzoates; Pyridoxal; Pyridoxine; Systems Analysis; Tryptophan; Xanthurenates | 1974 |
Quantitative analysis of serotonin biosynthesis in endotoxemia.
Topics: Animals; Carbon Radioisotopes; Female; Injections, Intraperitoneal; Kynurenine; Mice; Salmonella typhimurium; Serotonin; Shock, Septic; Tryptophan | 1974 |
Terminal synthesis of xanthommatin in Drosophila melanogaster. 3. Mutational pleiotropy and pigment granule association of phenoxazinone synthetase.
Topics: Amino Acids; Animals; Drosophila melanogaster; Genes; Kynurenine; Models, Biological; Mutation; ortho-Aminobenzoates; Oxazines; Oxidoreductases; Pigments, Biological; Tryptophan; Xanthenes | 1973 |
Effects of high tryptophan doses and two experimental rations on the excretion of urinary tryptophan metabolites in cattle.
Topics: Acetates; Alcohols; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Carbon Isotopes; Cattle; Chromatography, Ion Exchange; Emphysema; Hydrogen-Ion Concentration; Indican; Indoleacetic Acids; Indoles; Intubation, Gastrointestinal; Kynurenine; Male; Picolinic Acids; Pulmonary Edema; Rumen; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan | 1972 |
[Effect of L tryptophan and DL kynurenine, administered separately and in combination, on certain tests relative to the central nervous system].
Topics: Administration, Oral; Anesthesia; Animals; Barbiturates; Central Nervous System; Drug Combinations; Drug Synergism; Kynurenine; Mice; Motion; Rotation; Traction; Tryptophan | 1972 |
Comparative studies on the in vivo effects of tartar emetic, vitamin B 6 , and the chelating agent 2,3-dimercaptopropanol (BAL) on the functional capacity of the tryptophan-niacin pathway in patients with schistosomiasis.
Topics: Acetates; Adolescent; Aminohippuric Acids; Antimony; Child; Dimercaprol; Emetics; Glucuronates; Humans; Indican; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxine; Schistosoma haematobium; Schistosomiasis; Tartrates; Tryptophan; Xanthurenates | 1972 |
The effect of burns on the metabolism of tryptophan in children.
Topics: Burns; Child; Child, Preschool; Creatinine; Humans; Kynurenic Acid; Kynurenine; Oxalates; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
[Increased kynurenine excretion and tryptophan loading in oligophrenic children with and without familial disposition].
Topics: Administration, Oral; Adolescent; Child; Female; Humans; Intellectual Disability; Kynurenine; Male; Pyridoxine; Tryptophan; Xanthurenates | 1972 |
[Pseudoscleroderma or scleroderma coexisting with phenylketonuria].
Topics: Child; Diagnosis, Differential; Female; Humans; Kynurenine; Phenylketonurias; Scleroderma, Localized; Skin; Tryptophan | 1972 |
Studies on the urinary excretion of certain tryptophan metabolites in diabetics.
Topics: Adolescent; Adult; Amino Acids; Diabetes Mellitus; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrogen; ortho-Aminobenzoates; Phenylbutyrates; Tryptophan; Xanthurenates | 1972 |
Tryptophan--niacin and tryptophan--serotonin pathways in weaning pigs with porphyria experimentally induced.
Topics: Animals; Bile; Carboxylic Acids; Erythrocytes; Female; Hydrolases; Kynurenine; Liver; Male; Nicotinic Acids; Porphyrias; Porphyrins; Pyridines; Skin; Swine; Tryptophan; Tryptophan Oxygenase | 1972 |
[Alterations of tryptophan metabolism via nicotinic acid in women taking contraceptives].
Topics: Contraceptives, Oral; Female; Humans; Kynurenine; Mestranol; Nicotinic Acids; Norethynodrel; Tryptophan | 1972 |
Tryptophan metabolism in man, rat and pig. Determination of tryptophan-pyrrolase and kinureninase in liver.
Topics: Adult; Animals; Dicarboxylic Acids; Erythema; Female; Humans; Hydrolases; Kynurenine; Lichen Planus; Liver; Lupus Erythematosus, Systemic; Male; Middle Aged; Parapsoriasis; Pellagra; Porphyrias; Pyridines; Rats; Scleroderma, Systemic; Skin Diseases; Species Specificity; Swine; Tryptophan; Tryptophan Oxygenase | 1972 |
[Urinary excretion of metabolites of the tryptophan-kynurenine pathway in healthy infants after an oral loading dose of L-tryptophan (author's transl)].
Topics: Administration, Oral; Age Factors; Body Weight; Child; Child, Preschool; Female; Humans; Kidney; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1972 |
Proceedings: Normal and pathological factors which affect tryptophan metabolism in man.
Topics: Breast Neoplasms; Female; Humans; Kynurenine; Pregnancy; Tryptophan; Tryptophan Oxygenase | 1972 |
[Proceedings: Endogenous carcinogens. Experimental induction of malignant tumors and leukemias by the tryptophan metabolites 3-hydroxyanthranilic acid and 3-hydroxykynurenine].
Topics: 3-Hydroxyanthranilic Acid; Animals; Carcinoma; Kynurenine; Leukemia, Experimental; Lung Neoplasms; Mice; Neoplasms, Experimental; ortho-Aminobenzoates; Tryptophan; Urinary Bladder Neoplasms | 1972 |
[Proceedings: Tryptophan metabolism in untreated phenylketonuria and in vitamin B6 dependent cramps].
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Carboxylic Acids; Child; Child, Preschool; Humans; Hydroxyquinolines; Intellectual Disability; Kynurenic Acid; Kynurenine; Muscle Cramp; Nicotinic Acids; Phenylalanine; Phenylketonurias; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
Urinary excretion of quinolinic acid and other tryptophan metabolites after deoxypyridoxine or oral contraceptive administration.
Topics: Adolescent; Adult; Contraceptives, Oral; Ethinyl Estradiol; Ethynodiol Diacetate; Female; Humans; Kynurenine; Lynestrenol; Male; Mestranol; Norethindrone; ortho-Aminobenzoates; Pyridines; Pyridoxine; Tryptophan; Xanthurenates | 1973 |
The ultraviolet absorption spectra of chromatoid bodies of Entamoeba invadens in situ: an optical titration.
Topics: Animals; Crystallography; Entamoeba; Kynurenine; Ribosomes; Spectrophotometry, Ultraviolet; Triticum; Tryptophan | 1973 |
Tryptophan to niacin pathway in scleroderma and in dermatomyositis.
Topics: Adolescent; Adult; Aged; Dermatomyositis; Female; Humans; Hydrolases; Indoleacetic Acids; Indoles; Kynurenine; Male; Middle Aged; Nicotinic Acids; Scleroderma, Localized; Scleroderma, Systemic; Skatole; Tryptophan | 1973 |
Studies on tryptophen metabolism in patients with bladder cancer.
Topics: Humans; Hydrolases; Kynurenine; Liver; Neoplasm Metastasis; Papilloma; Time Factors; Tryptophan; Tryptophan Oxygenase; Urinary Bladder Neoplasms | 1973 |
Tryptophan metabolism in breast cancer. Correlation with urinary steroid excretion.
Topics: 17-Hydroxycorticosteroids; Adult; Aged; Aminohippuric Acids; Androsterone; Breast Neoplasms; Etiocholanolone; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1973 |
[Tryptophan loading during fasting].
Topics: Fasting; Female; Humans; Kynurenine; Male; Obesity; Tryptophan; Xanthurenates | 1973 |
Metabolism of tryptophan in depressive disease.
Topics: Adult; Bipolar Disorder; Depression; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Metabolic Clearance Rate; Middle Aged; Personality Disorders; Pyridoxine; Tryptamines; Tryptophan | 1973 |
Spectral studies on normal and cataractous intact human lenses.
Topics: Cataract; Crystallins; Humans; Kynurenine; Lens, Crystalline; Pigmentation; Spectrum Analysis; Tryptophan | 1973 |
Photo-oxidation of lens proteins by sunlight in the presence of fluorescent derivatives of kynurenine, isolated from the human lens.
Topics: Amino Acids; Chromatography, Gel; Color; Crystallins; Cysteine; Fluorescence; Histidine; Humans; Kynurenine; Methionine; Oxidation-Reduction; Peptide Hydrolases; Photochemistry; Spectrum Analysis; Sunlight; Tryptophan; Tyrosine | 1973 |
The binding of photo-oxidized tryptophan to a lens gamma-crystallin.
Topics: Amino Acids; Animals; Cattle; Chromatography; Chromatography, Gel; Crystallins; In Vitro Techniques; Kynurenine; Molecular Weight; Oxidation-Reduction; Protein Binding; Radiation Effects; Spectrometry, Fluorescence; Spectrum Analysis; Tryptophan; Ultraviolet Rays | 1973 |
[Aromatic compounds in certain infectious diseases].
Topics: Amino Acids; Erysipelas; Homogentisic Acid; Humans; Indican; Infections; Kynurenine; Liver Diseases; Nicotinic Acids; Phenylpyruvic Acids; Pneumonia; Tryptophan; Tyrosine; Xanthurenates | 1973 |
Biosynthesis of niacin in livers of rats treated with prolonged administration of acetoacetate.
Topics: Acetoacetates; Animals; Depression, Chemical; Kynurenine; Liver; Male; Nicotinic Acids; ortho-Aminobenzoates; Rats; Time Factors; Tryptophan | 1973 |
Oral contraceptives, pyridoxine, and depression.
Topics: Animals; Brain Chemistry; Contraceptives, Oral; Depression; Estrogens; Female; Humans; Kynurenine; Nicotinic Acids; Norepinephrine; Pregnancy; Premenstrual Syndrome; Pyridoxine; Serotonin; Tryptophan; Vitamin B 6 Deficiency | 1973 |
The application of enzymic hydrolysis and tritium labelling to a study of the modification of tryptophyl residues in proteins.
Topics: Animals; Apoproteins; Cetacea; Chromatography, Ion Exchange; Dipeptidases; Hydrolysis; Indicators and Reagents; Kynurenine; Leucyl Aminopeptidase; Muramidase; Myoglobin; Nitrobenzenes; Ozone; Pronase; Sheep; Sulfenic Acids; Sunlight; Tritium; Tryptophan; Wool | 1973 |
Enzymatic conversion of L- and D-tryptophan to kynurenine by rat liver.
Topics: Animals; Binding, Competitive; Cell Nucleus; Cold Temperature; Drug Stability; Enzyme Induction; Kynurenine; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Stereoisomerism; Structure-Activity Relationship; Tryptophan; Tryptophan Oxygenase | 1974 |
Photo-oxidation of N'-formylkynurenine and tryptophan peptides by sunlight or simulated sunlight.
Topics: Formates; Kynurenine; Oxidation-Reduction; Peptides; Photochemistry; Sunlight; Tryptophan | 1974 |
Relationship of dietary tryptophan and niacin to tryptophan metabolism in schizophrenics and nonschizophrenics.
Topics: Acetates; Aminohippuric Acids; Diet; Female; Humans; Hydroxyindoleacetic Acid; Indican; Indoles; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Schizophrenia; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase; Vitamin B 6 Deficiency; Xanthurenates | 1974 |
Relationship of dietary tryptophan and niacin to tryptophan metabolism in alcoholics and nonalcoholics.
Topics: Acetates; Alcoholism; Aminohippuric Acids; Diet; Dietary Proteins; Female; Humans; Hydroxyindoleacetic Acid; Indican; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1974 |
Purification and resolution of the optical isomers of labeled tryptophan metabolites on powdered paper columns.
Topics: Autoradiography; Carbon Radioisotopes; Chromatography; Chromatography, Paper; Evaluation Studies as Topic; Kynurenine; Methods; Optical Rotation; ortho-Aminobenzoates; Paper; Tryptophan | 1974 |
Melanogenesis from tryptophan. Biogenetic experiments with Harding-Passey mouse melanoma.
Topics: Animals; Carbon Radioisotopes; Kynurenine; Melanins; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Tryptophan; Tyrosine | 1974 |
N-formyl-kynurenine, a tryptophan photooxidation product, as a photodynamic sensitizer.
Topics: Amino Acids; Kinetics; Kynurenine; Nucleotides; Oxidation-Reduction; Peptides; Photochemistry; Radiation Effects; Tryptophan; Ultraviolet Rays | 1974 |
The role of some tryptophan metabolites in certain diseases of the genito-urinary system.
Topics: Chromatography, Thin Layer; Contraceptives, Oral; Female; Humans; Hydroxides; Hyperplasia; Kidney Calculi; Kidney Neoplasms; Kynurenine; Male; ortho-Aminobenzoates; Ovarian Neoplasms; Prostatic Diseases; Prostatic Neoplasms; Retroperitoneal Fibrosis; Tryptophan; Urinary Bladder Neoplasms; Urinary Calculi; Urinary Tract Infections; Urologic Diseases; Xanthurenates | 1974 |
[Changes in the enzyme activities and metabolites of tryptophan in the bees, Vespa lewisi C (author's transl)].
Topics: Animals; Bees; Hydrolases; Kynurenine; Larva; Mixed Function Oxygenases; Pupa; Transaminases; Tryptophan; Tryptophan Oxygenase | 1974 |
Purification and some properties of tryptophanase from Bacillus alvei.
Topics: Bacillus; Electrophoresis; Enzymes; Immunodiffusion; Kinetics; Kynurenine; Lyases; ortho-Aminobenzoates; Tryptophan | 1966 |
[Induction of kynureninase by kynurenine, tryptophan and 5-methyl-tryptophan in Coprinus radiatus].
Topics: Enzyme Induction; Fungi; Hydrolases; Kynurenine; Mutation; Tryptophan | 1967 |
Tryptophan catabolism during sporulation in Bacillus cereus.
Topics: Bacillus cereus; Chromatography; Culture Media; Glucose; Hydrogen-Ion Concentration; Hydrolases; Kynurenine; ortho-Aminobenzoates; Spores; Tryptophan; Tryptophan Oxygenase | 1970 |
[Tryptophan metabolism in pyridoxine-dependent convulsions].
Topics: Chemistry, Clinical; Child; Child, Preschool; Chromatography, Thin Layer; Epilepsy, Tonic-Clonic; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Spectroscopy; Mass Spectrometry; ortho-Aminobenzoates; Pyridoxine; Quinolines; Seizures; Tryptophan; Xanthurenates | 1971 |
Studies with tryptophan metabolites in vitro. V. Effect of the methanesulphonate derivative of hycanthone (etrenol) and lead acetate on kynureninase and kynurenine transaminase of normal mouse liver.
Topics: Acetates; Anthelmintics; Ethylamines; Hydrolases; Ketones; Kynurenic Acid; Kynurenine; Lead; Liver; ortho-Aminobenzoates; Osmolar Concentration; Pyridoxal Phosphate; Spectrum Analysis; Sulfonic Acids; Sulfur; Transaminases; Tryptophan; Ultraviolet Rays; Xanthenes | 1972 |
Oral contraceptives and tryptophan metabolism: effects of oestrogen in low dose combined with a progestagen and of a low-dose progestagen (megestrol acetate) given alone.
Topics: Chromatography, Thin Layer; Contraceptives, Oral; Depression, Chemical; Ethinyl Estradiol; Female; Glucose Tolerance Test; Humans; Kynurenine; Megestrol; Mestranol; Norethindrone; ortho-Aminobenzoates; Pyridoxine; Time Factors; Tryptophan; Xanthurenates | 1972 |
Experimental vitamin B 6 deficiency and the effect of oestrogen-containing oral contraceptives on tryptophan metabolism and vitamin B 6 requirements.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Contraceptives, Oral; Diet; Erythrocytes; Estrogens; Female; Humans; Kynurenine; Male; Nutritional Requirements; Pyridoxine; Time Factors; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
Effects of dietary vitamin B 6 deficiency and oral contraceptives on the spontaneous urinary excretion of 3-hydroxyanthranilic acid.
Topics: Adult; Carboxylic Acids; Contraceptives, Oral; Creatinine; Electrophoresis; Ethinyl Estradiol; Female; Humans; Kynurenine; Male; Mestranol; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxine; Ribonucleotides; Tryptophan; Vitamin B 6 Deficiency | 1972 |
[Disorders of tryptophan metabolism in bladder neoplasms].
Topics: Female; Humans; Kynurenine; Male; Methionine; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxine; Seasons; Tryptophan; Urinary Bladder Neoplasms | 1972 |
Tryptophan metabolism in rheumatoid neuropathies.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Child; Child, Preschool; Electrophysiology; Female; Humans; Kynurenine; Male; Middle Aged; Neurologic Manifestations; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxal Phosphate; Pyridoxine; Tryptophan; Xanthurenates | 1972 |
[Diagnostic study of vitamin changes through the biochemical analysis of hair. Study in the rat. II. Effects of riboflavin and pyridoxine changes on tryptophan metabolism].
Topics: Animals; Color; Hair; Kynurenine; Nicotinic Acids; Nitrogen; Pigments, Biological; Pyridoxine; Rats; Riboflavin; Solubility; Tryptophan | 1972 |
Tryptophan metabolism in early and advanced breast cancer and carcinoma of the cervix.
Topics: Administration, Oral; Adult; Aged; Bone Neoplasms; Breast Neoplasms; Carcinoma; Female; Humans; Kynurenine; Lymphatic Metastasis; Mastectomy; Middle Aged; Neoplasm Metastasis; ortho-Aminobenzoates; Pleural Effusion; Tryptophan; Uterine Cervical Neoplasms; Xanthurenates | 1972 |
Metabolism of C 14 labeled enantiomers of tryptophan, kynurenine and hydroxykynurenine in humans with scleroderma.
Topics: Adult; Carbon Dioxide; Carbon Isotopes; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Phenols; Picolinic Acids; Respiration; Scleroderma, Localized; Scleroderma, Systemic; Stereoisomerism; Time Factors; Tryptophan; Xanthurenates | 1972 |
Studies on the structure in solution of -lactalbumin.
Topics: Air; Albumins; Animals; Cattle; Chromatography, DEAE-Cellulose; Chromatography, Gel; Circular Dichroism; Copper; Disulfides; Formates; Kinetics; Kynurenine; Light; Methionine; Oxidation-Reduction; Photochemistry; Protein Conformation; Radiation Effects; Spectrophotometry; Sulfoxides; Tryptophan; Ultraviolet Rays | 1972 |
[Metabolism of amino acids, especially tryptophan, during radiotherapy].
Topics: Amino Acids; Humans; Hydroxyproline; Kynurenine; ortho-Aminobenzoates; Radiotherapy; Time Factors; Tryptophan; Xanthurenates | 1972 |
[Identification of oxindole and 3-indolecarbaldehyde in the urine of patients with untreated phenylketonuria].
Topics: Aldehydes; Carbamates; Chromatography, Thin Layer; Humans; Indoles; Kynurenine; Mass Spectrometry; Nicotinic Acids; Phenylketonurias; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tryptophan | 1972 |
D-Tryptophan pyrrolase activity in the liver and the intestine of the rat.
Topics: Acetates; Adrenal Glands; Adrenalectomy; Animals; Cell Nucleus; Cortisone; Enzyme Induction; Intestinal Mucosa; Intestine, Small; Kynurenic Acid; Kynurenine; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Neomycin; ortho-Aminobenzoates; Rats; Stereoisomerism; Subcellular Fractions; Tryptophan; Tryptophan Oxygenase | 1972 |
The role of tryptophan metabolites in regulating gluconeogenesis.
Topics: Amino Acids; Animals; Carboxy-Lyases; Depression, Chemical; Enzyme Induction; Fatty Acids; Gluconeogenesis; Indoles; Kidney; Kynurenine; Liver; Mitochondria; Mitochondria, Liver; ortho-Aminobenzoates; Phenylbutyrates; Pyridines; Pyruvates; Quinolines; Rats; Stimulation, Chemical; Tryptophan | 1971 |
Anergy and tryptophan metabolism in Hodgkin's disease.
Topics: Adolescent; Adult; Age Factors; Amino Acids; Anemia; Antigens; Candida; Coccidioides; Deficiency Diseases; Female; Histoplasmin; Hodgkin Disease; Humans; Kynurenine; Lymphopenia; Male; Middle Aged; Phenylbutyrates; Pyridoxal Phosphate; Sex Factors; Skin Tests; Tryptophan; Tuberculin; Xanthurenates | 1971 |
Identification of an error in the tryptophan--niacin pathway in carriers of some dermatoses conditioned or aggravated by sunlight.
Topics: Adult; Aged; Animals; Atrophy; Cataract; Female; Gastric Juice; Humans; Hydrolases; Kynurenine; Light; Lupus Erythematosus, Discoid; Male; Middle Aged; Nicotinic Acids; Pellagra; Pigmentation Disorders; Porphyrias; Rats; Rothmund-Thomson Syndrome; Skin; Skin Diseases; Sunlight; Transaminases; Tryptophan; Urticaria | 1971 |
Determination of metabolites of tyrosine and of tryptophan and related compounds by gas-liquid chromatography.
Topics: Animals; Chromatography, Gas; Indoles; Kynurenine; Phenylalanine; Rats; Serotonin; Silicon; Tryptamines; Tryptophan; Tyrosine | 1971 |
Paramagnetic metal ions as protectors of selected regions of protein molecules from photodynamic action.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Cobalt; Copper; Drug Stability; Glutamates; Guanidines; Histidine; Hydrogen-Ion Concentration; Kynurenine; Light; Methionine; Micrococcus; Muramidase; Oxidation-Reduction; Pancreas; Photochemistry; Protein Denaturation; Radiation Effects; Ribonucleases; Spectrophotometry; Sulfoxides; Temperature; Time Factors; Trypsin; Tryptophan; Tyrosine; Ultraviolet Rays; Zinc | 1971 |
[Balance and metabolism of tryptophan in pneumonia].
Topics: Adult; Chronic Disease; Focal Infection; Humans; Kynurenine; Male; Pneumonia; Spectrophotometry; Tryptophan | 1971 |
A method for the determination of urinary metabolites of tryptophan.
Topics: Adult; Chromatography, Thin Layer; Evaluation Studies as Topic; Female; Fluorescence; Fluorometry; Humans; Hydrolases; Hydrolysis; Kynurenine; Methods; Middle Aged; ortho-Aminobenzoates; Spectrum Analysis; Tryptophan; Ultraviolet Rays; Xanthurenates | 1971 |
Studies on the photooxidation of tryptophan.
Topics: Amino Acids; Ammonia; Aspartic Acid; Chromatography, Thin Layer; Electrophoresis, Paper; Formates; Hydrochloric Acid; Kinetics; Kynurenine; Light; Models, Structural; Nitrogen; Oxygen; Photolysis; Quinazolines; Radiation Effects; Tryptophan; Water | 1971 |
Formation of N'-formylkynurenine in proteins from lens and other sources by exposure to sunlight.
Topics: Animals; Cataract; Cattle; Chromatography; Crystallins; Electrophoresis; Fluorescence; Humans; In Vitro Techniques; Kynurenine; Muramidase; Oxidation-Reduction; Serum Albumin; Spectrophotometry; Sunlight; Tryptophan | 1971 |
Tryptophan to niacin pathway in lupus erythematosus.
Topics: Adolescent; Adult; Aged; Child; Female; Humans; Kynurenine; Lupus Erythematosus, Systemic; Male; Middle Aged; Nicotinic Acids; Photosensitivity Disorders; Sex Factors; Tryptophan | 1971 |
[The significance of the disturbance of tryptophan metabolism in radiation injury].
Topics: Animals; Female; Kynurenine; Leukemia, Radiation-Induced; Mice; Neoplasms, Radiation-Induced; Radiation Injuries, Experimental; Tryptophan; Xanthurenates | 1966 |
Interruption of the tryptophan-nicotinic acid pathway by penicillamine-induced pyridoxine deficiency in patients with Wilson's disease and in experimental animals.
Topics: Animals; Carbon Isotopes; Chromatography; Female; Hepatolenticular Degeneration; Humans; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Penicillamine; Rats; Tryptophan; Urine; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
Dietary protein--its relationship to vitamin B6 requirements and function.
Topics: Adult; Amino Acids; Creatinine; Dietary Proteins; Electroencephalography; Humans; Kynurenine; Male; Nutritional Requirements; Protein Deficiency; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
Tryptophan loading and pyridoxine treatment in children with epilepsy.
Topics: Child; Epilepsy; Humans; Kynurenine; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
The tryptophan load as a test for pyridoxine deficiency in hospitalized patients.
Topics: Adult; Aged; Arteriosclerosis; Female; Gastrointestinal Diseases; Humans; Kynurenine; Male; Middle Aged; Neoplasms; Pyridoxine; Steroids; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
Antivitamin B6 effect of D-penicillamine.
Topics: Arthritis, Rheumatoid; Humans; Kynurenine; Penicillamine; Pyridoxine; Rheumatoid Factor; Stereoisomerism; Tryptophan; Xanthurenates | 1969 |
[On degradation of tryptophan and kynurenin following whole body irradiation in liver tissue of the mouse].
Topics: Animals; Hydrolases; Kynurenine; Liver; Mice; Oxidoreductases; Pyridoxine; Radiation Effects; Transaminases; Tryptophan | 1966 |
Tryptophan metabolism in the normal and tympanitic bovine.
Topics: 5-Hydroxytryptophan; Animals; Cattle; Cattle Diseases; Indoleacetic Acids; Kynurenine; Temperature; Tritium; Tryptamines; Tryptophan | 1968 |
Urinary exeretion of phenolic and indolic compounds, metacatecholamines, and VMA by full-term and premature infants.
Topics: 5-Hydroxytryptophan; Benzoates; Catecholamines; Cinnamates; Creatinine; Humans; Indoleacetic Acids; Infant, Newborn; Infant, Premature; Kynurenine; Lactates; Mandelic Acids; Phenylacetates; Phenylalanine; Phenylpyruvic Acids; Phthalic Acids; Propionates; Tryptophan; Tyrosine | 1968 |
5-hydroxykynurenine decarboxylase in rat intestine.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Carboxy-Lyases; Chromatography, Paper; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Intestine, Small; Kidney; Kynurenine; Male; Mitochondria, Liver; Monoamine Oxidase; Myocardium; Phenylbutyrates; Quinolines; Rats; Spectrophotometry; Tryptophan | 1970 |
Chromatographic separation of tryptophan metabolites.
Topics: 5-Hydroxytryptophan; Chromatography, Gel; Chromatography, Ion Exchange; Fluorometry; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Indoleacetic Acids; Indoles; Kynurenic Acid; Kynurenine; Methods; Methylcellulose; Picolinic Acids; Pyridines; Serotonin; Spectrophotometry; Tryptamines; Tryptophan; Ultraviolet Rays; Xanthurenates | 1970 |
[Pterin chemistry. Hydroxylation of tryptophan with tetrahydopterin under physiological conditions].
Topics: 5-Hydroxytryptophan; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Heterocyclic Compounds; Kynurenine; Melanins; Oxygen; Solutions; Tryptophan | 1970 |
The influence of sex, age, synthetic oestrogens, progestogens and oral contraceptives on the excretion of urinary tryptophan metabolites.
Topics: Adult; Age Factors; Carboxy-Lyases; Carcinogens; Contraceptives, Oral; Ethinyl Estradiol; Female; Glucuronates; Hippurates; Humans; Kynurenic Acid; Kynurenine; Male; Menopause; Menstruation; Middle Aged; Norethindrone; ortho-Aminobenzoates; Ovulation; Pyridoxine; Sex Factors; Tryptophan; Xanthurenates | 1970 |
Tryptophan induction of the serotonin and kynurenine pathways in the early amphibian embryo.
Topics: 5-Hydroxytryptophan; Animals; Anura; Carbon Isotopes; Chloramphenicol; Chlorpromazine; Chromatography, Thin Layer; Culture Techniques; Depression, Chemical; Embryo, Nonmammalian; Enzyme Induction; Ethanol; Indoles; Iproniazid; Kynurenine; Melatonin; Mixed Function Oxygenases; Protein Biosynthesis; RNA; Serotonin; Tryptophan; Tryptophan Oxygenase | 1971 |
-electronic structures of tryptophan metabolites. I. Tryptophan, kynurenine, anthranilic acid and related compounds.
Topics: 5-Hydroxytryptophan; Kynurenine; ortho-Aminobenzoates; Quantum Theory; Tryptophan | 1971 |
Modification of tryptophan residues in trypsin, alpha-chymotrypsin and pepsinogen.
Topics: Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Enzyme Precursors; Kynurenine; Pepsin A; Spectrophotometry; Trypsin; Tryptophan | 1964 |
Tryptophan metabolism in the synovial fluid in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Blood Sedimentation; Humans; Kynurenic Acid; Kynurenine; Nicotinic Acids; ortho-Aminobenzoates; Osteoarthritis; Synovial Fluid; Tryptophan; Xanthurenates | 1969 |
Chemical modification of the tryptophan residue in cobratoxin.
Topics: Amino Acids; Animals; Bromides; Chemical Phenomena; Chemistry; Female; Formates; Kynurenine; Male; Mice; Nitrobenzenes; Ozone; Snakes; Spectrophotometry; Toxins, Biological; Tryptophan; Venoms | 1969 |
Influence of androgens upon tryptophan metabolism in man.
Topics: Adult; Anabolic Agents; Humans; Hydrocortisone; Kynurenic Acid; Kynurenine; Male; Methyltestosterone; Tryptophan; Xanthurenates | 1969 |
The action of pyridoxine in primary hyperoxaluria.
Topics: Carbohydrate Metabolism, Inborn Errors; Glyoxylates; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Oxalates; Pyridoxine; Tryptophan | 1969 |
[Tryptophan is not utilized for respiration by insects].
Topics: Animals; Ants; Bees; Carbon Dioxide; Carbon Isotopes; Glutarates; Insecta; Kynurenine; Scorpions; Tryptophan | 1969 |
The arthritogenic effect of indole, skatole and other tryptophan metabolites in rabbits.
Topics: Animals; Arthritis; Arthritis, Rheumatoid; Cell Membrane; Indoles; Kynurenine; Lipid Metabolism; Rabbits; Skatole; Tryptophan | 1969 |
In vivo effect of tartar emetic on tryptophan metabolism in patients with schistosomiasis.
Topics: Adolescent; Adult; Child; Humans; Hydrolases; Kynurenine; Pyridoxine; Schistosomiasis; Tartrates; Tryptophan; Urinary Bladder Neoplasms | 1969 |
[Urinary elimination of some tryptophan metabolites in humans during hyperthyroidism before and after treatment with pyridoxine].
Topics: Hippurates; Humans; Hyperthyroidism; Kynurenine; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Xanthurenates | 1969 |
[Tryptophan-pyrrolase activity in patients with neoplasms of various types].
Topics: Humans; Kynurenine; Liver; Neoplasms; Tryptophan; Tryptophan Oxygenase | 1969 |
Tryptophan metabolism, protein and alkaloid synthesis in saprophytic cultures of the ergot fungus (Claviceps sp.).
Topics: Ascomycota; Carbon Isotopes; Ergot Alkaloids; Indoles; Kynurenine; Leucine; Methods; Protein Binding; Protein Biosynthesis; Tryptophan | 1969 |
[Tryptophan-nicotinic acid metabolism in hyperthyroid subjects and various observations relative to pyridoxine administration].
Topics: Adult; Female; Hippurates; Humans; Hyperthyroidism; Kynurenine; Male; Nicotinic Acids; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Xanthurenates | 1969 |
Serum kynurenine in bronchial asthma and chronic bronchitis.
Topics: Adolescent; Adult; Aged; Asthma; Bronchitis; Cortisone; Female; Humans; Kynurenine; Male; Methods; Middle Aged; Nicotinic Acids; Protein Biosynthesis; Serotonin; Spirometry; Tryptophan; Tryptophan Oxygenase | 1970 |
Excretion of urinary tryptophan metabolites by patients with congenital hypoplastic anemia (Diamond-Blackfan syndrome).
Topics: Adolescent; Anemia, Aplastic; Body Weight; Child; Child, Preschool; Erythrocytes, Abnormal; Erythropoiesis; Female; Humans; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan | 1970 |
The action of pyridoxine in primary hyperoxaluria.
Topics: Adolescent; Adult; Child; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolic Diseases; Mixed Function Oxygenases; ortho-Aminobenzoates; Oxalates; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1970 |
Effect of acetoacetate on the activities of certain liver enzymes taking part in the tryptophan to nicotinic acid pathway in rats.
Topics: Acetoacetates; Animals; Benzoates; Body Weight; Carboxy-Lyases; Depression, Chemical; Hydrolases; Kynurenine; Liver; Male; Nicotinic Acids; Nitrogen; Organ Size; ortho-Aminobenzoates; Oxidoreductases; Picolinic Acids; Rats; Stimulation, Chemical; Time Factors; Tryptophan; Tryptophan Oxygenase | 1970 |
Abnormalities of tryptophan metabolism and plasma pyridoxal phosphate in Hodgkin's disease.
Topics: Adolescent; Adult; Anemia; Carbon Isotopes; Female; Hodgkin Disease; Humans; Kynurenine; Male; Middle Aged; Pyridoxal Phosphate; Pyridoxine; Skin Tests; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1970 |
Induction of kynureninase in Neurospora.
Topics: Cycloheximide; Enzyme Induction; Hydrolases; Kynurenine; Neurospora; RNA, Messenger; Tryptophan | 1970 |
Hypobaric hypoxia: effects on hepatic tryptophan oxygenase periodicity in mice.
Topics: Adrenalectomy; Animals; Atmospheric Pressure; Circadian Rhythm; Cortisone; Dactinomycin; Enzyme Induction; Hydrocortisone; Hypoxia; Kynurenine; Liver; Male; Mice; Pituitary-Adrenal System; Spectrophotometry; Stereoisomerism; Stress, Physiological; Tryptophan; Tryptophan Oxygenase | 1970 |
Metabolism of D- and L-tryptophan-7 alpha-14C in rats and the effects of unlabeled enantiomers.
Topics: Aminohippuric Acids; Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Kynurenic Acid; Kynurenine; Nicotinic Acids; Picolinic Acids; Pyridines; Rats; Stereoisomerism; Tryptophan; Xanthurenates | 1970 |
Studies on tryptophan metabolism in protein-calorie malnutrition.
Topics: Aminohippuric Acids; Blood Proteins; Child, Preschool; Diet Therapy; Female; Glucuronates; Humans; Infant; Kwashiorkor; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Protein Deficiency; Pyridoxine; Skin Diseases; Tryptophan; Xanthurenates | 1970 |
Tryptophan: abnormal metabolism in pellagra patients.
Topics: Aminohippuric Acids; Black People; Female; Glucuronates; Humans; Kynurenine; Pellagra; South Africa; Tryptophan; Tryptophan Oxygenase | 1970 |
Tryptophan metabolism in newborn low-birth-weight infants.
Topics: Birth Weight; Glucuronidase; Humans; Infant, Newborn; Infant, Premature; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan | 1970 |
The functional capacity of the tryptophan-niacin pathway in pellagrous children.
Topics: Amines; Aminohippuric Acids; Child; Child, Preschool; Glucuronates; Humans; Kynurenic Acid; Kynurenine; Nicotinic Acids; ortho-Aminobenzoates; Pellagra; Tryptophan | 1970 |
[New viewpoints on the pathogenesis of pellagra].
Topics: Humans; Kynurenine; Metabolic Diseases; Pellagra; Pyridoxine; Riboflavin; Tryptophan | 1970 |
The oxygenated form of L-tryptophan 2,3-dioxygenase as reaction intermediate.
Topics: Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Heme; Iron; Kinetics; Kynurenine; Oxygen; Protein Binding; Pseudomonas; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1970 |
Tryptophan metabolism in depression.
Topics: Administration, Oral; Adult; Depression; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sex Factors; Tryptophan | 1970 |
Urinary levels of kynurenine and 3-hydroxykynurenine in the rat: effects of triamterene.
Topics: Amino Acids; Animals; Female; Injections, Intraperitoneal; Kynurenine; Metabolism; Mixed Function Oxygenases; Phenylbutyrates; Pteridines; Rats; Renal Aminoacidurias; Tetrahydrofolate Dehydrogenase; Triamterene; Tryptophan; Urination | 1970 |
Differences in tryptophan metabolism between breast cancer patients with and without cancer at other sites.
Topics: Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Female; Humans; Kynurenic Acid; Kynurenine; Lung Neoplasms; Male; Neoplasm Metastasis; Ovarian Neoplasms; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1970 |
[Disturbance of tyrosine and tryptophane metabolism in depression].
Topics: Adolescent; Adult; Circadian Rhythm; Depression; Female; Humans; Kynurenine; Male; Middle Aged; Tryptophan; Tyrosine | 1970 |
[Chronic urticaria and vitamin B6 dependent disorders in tryptophan metabolism].
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Female; Humans; Kynurenine; Male; Middle Aged; Pyridoxine; Tryptophan; Urticaria; Xanthurenates | 1970 |
Studies on the effect of reserpine therapy on the functional capacity of the tryptophan-niacin pathway in smoker and non-smoker males.
Topics: Adult; Aminohippuric Acids; Carboxy-Lyases; Catecholamines; Glucuronates; Humans; Isonicotinic Acids; Kynurenic Acid; Kynurenine; Male; Nicotine; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Pyridoxal Phosphate; Pyridoxine; Reserpine; Smoking; Tryptophan; Xanthurenates | 1970 |
[Vitamin B6 deficiency in patients with leg ulcers and in their family members].
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Paper; Female; Humans; Kynurenine; Leg Ulcer; Male; Middle Aged; Pedigree; Pyridoxal Phosphate; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1970 |
Direct and steam distillation autoanalyzer methods for assay of diazotizable aromatic amine metabolites of tryptophan in urine and in serum.
Topics: Acetates; Aminohippuric Acids; Autoanalysis; Chemistry, Clinical; Colorimetry; Ethylenediamines; Female; Glucuronates; Humans; Hydrolases; Indican; Kynurenine; Male; Methods; Naphthalenes; Nitrites; ortho-Aminobenzoates; Steam; Tryptophan; Tryptophan Oxygenase | 1970 |
[Discriminatory analysis of data on tryptophan metabolism in patients with rheumatoid arthritis and normal subjects after amino acid load test].
Topics: Amino Acids; Analysis of Variance; Arthritis, Rheumatoid; Humans; Kynurenine; Tryptophan | 1970 |
[Changes of tryptophan-nicotinic acid metabolism and the blood levels of ceruloplasmin and transferrin during pregnancy and treatment with contraceptives or estrogens].
Topics: Ceruloplasmin; Contraceptives, Oral; Estrogens; Female; Humans; Kynurenine; Male; Nicotinic Acids; Pregnancy; Progesterone; Testosterone; Transferrin; Tryptophan; Xanthurenates | 1970 |
Gas chromatographic analysis of tryptophan metabolites.
Topics: Acetophenones; Amines; Chromatography, Gas; Fluoroacetates; Kynurenine; Methods; Methylation; ortho-Aminobenzoates; Tryptophan | 1971 |
The effect of estrogens on pyridoxal phosphate dependent enzymes in patients with cancer of the prostate.
Topics: Alanine Transaminase; Aminohippuric Acids; Aspartate Aminotransferases; Carboxy-Lyases; Chlorotrianisene; Coenzymes; Diethylstilbestrol; Erythrocytes; Glucuronates; Humans; Kynurenine; Male; ortho-Aminobenzoates; Prostatic Neoplasms; Pyridoxal Phosphate; Pyridoxine; Tryptophan | 1971 |
Regulation of the pathway for the degradation of anthranilate in Aspergillus niger.
Topics: Aspergillus; Benzoates; Carboxy-Lyases; Catechols; Cell-Free System; Chemical Phenomena; Chemistry; Colorimetry; Culture Media; Cycloheximide; Decarboxylation; Enzyme Induction; Hydrogen-Ion Concentration; Kynurenine; Mixed Function Oxygenases; ortho-Aminobenzoates; Oxidation-Reduction; Oxygenases; Salicylates; Spectrophotometry; Tryptophan | 1971 |
Relationships between excretion of steroid hormones and tryptophan metabolites in patients with breast cancer.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Administration, Oral; Adult; Age Factors; Breast Neoplasms; Chromatography, Thin Layer; Female; Fluorescence; Humans; Hydrolases; Kynurenine; Middle Aged; Neurospora; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1971 |
The role of tryptophan pyrrolase adaptation in the excretion of xanthurenic acid by rats deficient in vitamin B 6.
Topics: Animals; Cycloheximide; Enzyme Induction; Hydrocortisone; Hydrolases; Injections, Intraperitoneal; Kynurenine; Liver; Male; Pyridoxine; Rats; Sodium Chloride; Time Factors; Tryptophan; Tryptophan Oxygenase; Urine; Vitamin B 6 Deficiency; Xanthurenates | 1971 |
Tryptophan load test and pyridoxine treatment in epileptic children.
Topics: Epilepsy; Humans; Hydrolases; Kinetics; Kynurenine; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency | 1967 |
[Studies on the pathogenesis of acrodermatitis enteropathica Danbolt-Closs].
Topics: Acrodermatitis; Adolescent; Amino Acids; Child; Female; Humans; Kynurenine; Liver; Tryptophan; Tyrosine | 1967 |
[Genetic disorders in tryptophan metabolism].
Topics: Hartnup Disease; Humans; Kynurenine; Metabolism, Inborn Errors; Tryptophan | 1967 |
[Tryptophan and tyrosine administration in acrodermatitis enteropathica (Danbolt)].
Topics: Acrodermatitis; Adult; Child; Female; Humans; Indican; Intestinal Diseases; Kynurenic Acid; Kynurenine; Male; Tryptophan; Tyrosine; Xanthurenates | 1967 |
[Studies on the tryptophan metabolism of Streptomycetes. II. Quantitative determination of appearing tryptophan metabolites and their metabolism].
Topics: Colorimetry; Indoleacetic Acids; Indoles; Kynurenine; Nicotinic Acids; ortho-Aminobenzoates; Streptomyces; Tryptamines; Tryptophan | 1967 |
[Carcinoid syndrome (apropos of 1 case). II. Biologic study and therapeutic note].
Topics: Autoradiography; Carbon Isotopes; Humans; Indoles; Kynurenine; Lysergic Acid Diethylamide; Malignant Carcinoid Syndrome; Methyldopa; Phenothiazines; Serotonin; Tryptamines; Tryptophan | 1967 |
The influence of sex, age and breast cancer on tryptophan metabolism.
Topics: Age Factors; Breast Neoplasms; Estrogens; Female; Kynurenine; Menstruation; ortho-Aminobenzoates; Ovulation; Sex Factors; Tryptophan; Xanthurenates | 1967 |
[Tryptophan, kynurenine, 3-hydroxykynurenine and ommochrome content of the hibernating egg of the silkworm Bombyx mori during development].
Topics: Animals; Bombyx; Female; Hibernation; Kynurenine; Ovum; Pigments, Biological; Tryptophan | 1967 |
Potentiation of endotoxin shock by oral L-tryptophan.
Topics: Ammonia; Animals; Chromatography, Paper; Dogs; Endotoxins; Glucuronates; Hydrocortisone; Indoles; Kynurenic Acid; Kynurenine; Neomycin; ortho-Aminobenzoates; Portal Vein; Serotonin; Shock, Septic; Tryptophan | 1968 |
Circadian periodicity of tryptophan metabolism.
Topics: Adult; Circadian Rhythm; Female; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1968 |
Tryptophan metabolism in some intestinal helminthiases.
Topics: Adolescent; Adult; Aminohippuric Acids; Ancylostomiasis; Ascariasis; Humans; Indican; Intestinal Diseases, Parasitic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1968 |
Isolation and assay of radioactive urinary kynurenic and xanthurenic acids.
Topics: Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Humans; Kynurenic Acid; Kynurenine; Methods; Spectrum Analysis; Tryptophan; Ultraviolet Rays; Xanthurenates | 1968 |
Alteration of tryptophan-mediated regulation in Neurospora crassa by indoleglycerol phosphate.
Topics: Enzyme Induction; Hydrolases; Imidazoles; Indoles; Kynurenine; Ligases; Molecular Biology; Mutation; Neurospora; Tryptophan | 1968 |
Selective and quantitative photochemical conversion of the tryptophyl residues to kynurenine in lysozyme.
Topics: Acridines; Amino Acids; Kynurenine; Methods; Muramidase; Oxidation-Reduction; Spectrophotometry; Tryptophan | 1968 |
Circadian oscillation in rat liver tryptophan pyrrolase and its analysis by substrate and hormone induction.
Topics: Animals; Circadian Rhythm; Darkness; Enzyme Induction; Hydrocortisone; Kynurenine; Light; Liver; Male; Rats; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1968 |
Transport and further metabolism on intermediate compounds of the tryptophan-nicotinic acid ribonucleotide pathway by rat small intestine.
Topics: Animals; Biological Transport; Chromatography, Paper; Female; In Vitro Techniques; Kynurenic Acid; Kynurenine; Nicotinic Acids; Nucleotides; Rats; Tryptophan | 1968 |
Pigment studies on several eye-colour mutants of the honey bee, Apis mellifera.
Topics: Alleles; Animals; Bees; Chromatography, Paper; Eye; Kynurenine; Male; Molecular Biology; Mutation; Pigments, Biological; Pteridines; Tryptophan | 1968 |
Kinetics of urinary excretion of 3-hydroxykynurenine and 3-hydroxyanthranilic acid after tryptophan loading in man.
Topics: Adolescent; Adult; Child; Chromatography, Thin Layer; Epilepsy; Female; Humans; Hydrolases; Kynurenine; Male; ortho-Aminobenzoates; Oxidoreductases; Pyridoxine; Time Factors; Tryptophan; Tryptophan Oxygenase; Vitamin B 6 Deficiency; Xanthurenates | 1968 |
Effect of 4-desoxypyridoxine on the initial excretion rates of 3-hydroxykynurenine and 3-hydroxyanthranilic acid after tryptophan loading.
Topics: Adolescent; Adult; Chromatography, Thin Layer; Female; Humans; Hydrolases; Kynurenine; Male; Mestranol; Norethindrone; ortho-Aminobenzoates; Oxidoreductases; Pyridoxine; Time Factors; Tryptophan; Tryptophan Oxygenase | 1968 |
Tryptophan load tests in children with epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography; Epilepsy; Female; Humans; Kynurenine; Male; ortho-Aminobenzoates; Oxidoreductases; Pyridoxine; Tryptophan; Tryptophan Oxygenase | 1968 |
Studies with tryptophan metabolites in vitro. Kynurenine metabolism in kidneys of mice infested with Schistosoma mansoni.
Topics: Animals; Hydrolases; In Vitro Techniques; Kidney; Kynurenic Acid; Kynurenine; Mice; ortho-Aminobenzoates; Pyridoxal Phosphate; Schistosomiasis; Tryptophan; Urinary Bladder Neoplasms | 1968 |
[L-tryptophan metabolism in phenylketonuria].
Topics: Adolescent; Adult; Child; Diet Therapy; Female; Humans; Indoles; Kynurenine; Male; Phenylalanine; Phenylketonurias; Tryptophan; Tyrosine | 1968 |
Liver kynureninase activity of an infant with infantile spasm.
Topics: Aspartate Aminotransferases; Cerebral Palsy; Child; Child, Preschool; Erythrocytes; Female; Humans; Hydrolases; Indoleacetic Acids; Infant; Kynurenic Acid; Kynurenine; Liver; ortho-Aminobenzoates; Pyridoxine; Seizures; Spasm; Tryptophan; Xanthurenates | 1968 |
[Abnormal kynurenin excretion following tryptophan tolerance test in cerebrally impaired children].
Topics: Adult; Child; Child, Preschool; Female; Humans; Infant; Intellectual Disability; Kynurenine; Male; Tryptophan | 1968 |
Alterations of tryptophan metabolism induced by sleep deprivation.
Topics: Adult; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; ortho-Aminobenzoates; Sleep Deprivation; Tryptophan; Xanthurenates | 1968 |
Some new aspects of tryptophan degradation.
Topics: Adult; Age Factors; Chromatography; Female; Humans; Kynurenine; Male; Pregnancy; Sex Factors; Tryptophan; Urinary Bladder Neoplasms | 1968 |
[Studies on the excretion of tryptophan metabolites in patients with circumscript and progressive scleroderma].
Topics: Adult; Aged; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Scleroderma, Systemic; Tryptophan; Xanthurenates | 1968 |
The biochemical and clinical effect of pyridoxine in children with brain disorders.
Topics: Aminohippuric Acids; Child; Child, Preschool; Female; Humans; Infant; Intellectual Disability; Kynurenine; Male; ortho-Aminobenzoates; Pyridoxine; Seizures; Tryptophan; Xanthurenates | 1968 |
[On the influence of ovulation inhibitors on tryptophan metabolism in relation to vitamin B6].
Topics: Adult; Contraceptives, Oral; Female; Gestational Age; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Pregnancy Tests; Pyridoxine; Tryptophan; Xanthurenates | 1968 |
Studies on tryptophan metabolism in bilharzial bladder cancer patients.
Topics: Adult; Humans; Kynurenine; Male; Occupational Diseases; ortho-Aminobenzoates; Schistosomiasis; Tryptophan; Urinary Bladder Neoplasms; Vitamin B 6 Deficiency; Xanthurenates | 1968 |
Studies in the etiology and prevention of bladder carcinoma.
Topics: Ascorbic Acid; Carcinogens; Free Radicals; Humans; Kynurenine; Luminescent Measurements; ortho-Aminobenzoates; Oxidation-Reduction; Smoking; Tryptophan; Ultraviolet Rays; Urinary Bladder Neoplasms | 1968 |
[Urinary elimination of kynurenine and other tryptophan metabolites before and after administration of prednisolone to newborn infants].
Topics: Humans; Infant, Newborn; Injections, Intramuscular; Kidney; Kynurenine; Male; Prednisolone; Tryptophan | 1968 |
[Various current findings in the problem of pellagra].
Topics: Alcoholism; Deficiency Diseases; Diet; Feeding Behavior; Hartnup Disease; Humans; Isoniazid; Isonicotinic Acids; Italy; Kynurenine; Mexico; Pellagra; Thiosemicarbazones; Tryptophan; United States; Zea mays | 1968 |
The performic acid oxidation of egg-white lysozyme.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Paper; Cystine; Egg White; Electrophoresis; Formates; Kynurenine; Muramidase; Peptides; Peroxides; Spectrum Analysis; Tryptophan; Ultraviolet Rays | 1969 |
Effect of acetoacetate on urinary excretion of xanthurenic acid and other tryptophan metabolites in rats.
Topics: Acetoacetates; Animals; Hippurates; Kynurenic Acid; Kynurenine; Rats; Tryptophan; Xanthurenates | 1969 |
Mutagenic effect of 3-hydroxykynurenine and 3-hydroxyanthranilic acid.
Topics: Chromosome Aberrations; Culture Techniques; Embryo, Mammalian; Humans; Kynurenine; Mutagens; ortho-Aminobenzoates; Tryptophan | 1969 |
Synergistic and product induction of the enzymes of tryptophan metabolism in Pseudomonas acidovorans.
Topics: Amidohydrolases; Asparagine; Chloramphenicol; Enzyme Induction; Enzyme Repression; Glucose; Glutamates; Glutarates; Kynurenine; Pseudomonas; Succinates; Tryptophan; Tryptophan Oxygenase | 1969 |
Product induction in Pseudomonas acidovorans of a permease system which transports L-tryptophan.
Topics: Asparagine; Azides; Biological Transport, Active; Dinitrophenols; Enzyme Induction; Feedback; Kynurenine; Membrane Transport Proteins; Phenylalanine; Pseudomonas; Tryptophan; Tryptophan Oxygenase | 1969 |
Studies on the effect of D-penicillamine and N-acetyl-D-penicillamine on the excretion of some tryptophan metabolites in patients with cystinuria.
Topics: Adolescent; Adult; Child; Cystinuria; Female; Humans; Kynurenine; Male; ortho-Aminobenzoates; Penicillamine; Pyridoxine; Tryptophan | 1969 |
[Effects of cortisol on the urinary elimination of hydroxyindoles and kynurenine].
Topics: 17-Hydroxycorticosteroids; Adult; Depression, Chemical; Female; Fluorometry; Humans; Hydrocortisone; Hydroxyindoleacetic Acid; Kynurenine; Male; Serotonin; Stimulation, Chemical; Time Factors; Tryptophan | 1969 |
Effect of acetoacetate on biosynthesis of niacin in vitro.
Topics: Acetoacetates; Animals; Kynurenine; Liver; Male; Methods; Nicotinic Acids; Rats; Tryptophan | 1969 |
Effect of acetoacetate administration on urinary and tissue vitamin B6 in rats.
Topics: Acetoacetates; Animals; Injections, Intraperitoneal; Kynurenine; Liver; Male; Pyridoxine; Rats; Tryptophan; Xanthurenates | 1969 |
Tryptophan degradation in the developing chick.
Topics: Amidohydrolases; Animals; Animals, Newborn; Chick Embryo; Enzyme Induction; Hydrocortisone; Kynurenine; Liver; Tryptophan; Tryptophan Oxygenase | 1969 |
[Tryptophan metabolism in the synovial fluid in joint diseases].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child, Preschool; Chromatography, Paper; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Osteoarthritis; Synovial Fluid; Tryptophan; Xanthurenates | 1969 |
[The effect of tryptophan, serotonin, kynurenine, corticosteroids and peroxidases on the activity of tryptophan pyrrolase, the decarboxylase of 5-OH tryptophan and liver catalase in rats].
Topics: Adrenal Cortex Hormones; Animals; Carboxy-Lyases; Catalase; Female; Kynurenine; Liver; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1969 |
An analysis of the kinetics of rat liver tryptophan pyrrolase induction: the significance of both enzyme synthesis and degradation.
Topics: Animals; Hydrocortisone; In Vitro Techniques; Kinetics; Kynurenine; Liver; Oxygenases; Rats; Subcellular Fractions; Tryptophan; Tryptophan Oxygenase | 1964 |
On the activation and catalytic mechanism of microbial tryptophan pyrrolase.
Topics: Ascorbic Acid; Catalysis; Heme; In Vitro Techniques; Kynurenine; Oxygenases; Pseudomonas; Tryptophan; Tryptophan Oxygenase | 1964 |
Excretion of tryptophan metabolites in Friedreich's ataxia.
Topics: Friedreich Ataxia; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Tryptophan; Urine | 1965 |
The effect of pyridoxine on tryptophan metabolism in phenylketonuria.
Topics: Child; Child, Preschool; Chromatography, Ion Exchange; Diet Therapy; Humans; In Vitro Techniques; Infant; Infant, Newborn; Kynurenine; ortho-Aminobenzoates; Phenylketonurias; Pyridoxine; Tryptophan; Urine; Xanthurenates | 1965 |
[Determination of yields of radiation and chemical decomposition of tryptophan and guanine mathematical analysis of the absorption spectra of solutions].
Topics: Guanine; Kynurenine; ortho-Aminobenzoates; Radiation Effects; Spectrum Analysis; Tryptophan | 1965 |
Some aspects of tryptophan and niacin metabolism in young women consuming a low tryptophan diet supplemented with niacin.
Topics: Adult; Aminohippuric Acids; Deficiency Diseases; Diet; Female; Humans; Kynurenine; Nicotinic Acids; Tryptophan; Urine; Xanthurenates | 1966 |
The tryptophan load and pyridoxine deficiency.
Topics: Adult; Chromatography; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1966 |
D-amino acid dehydrogenases of Pseudomonas fluorescens.
Topics: Amino Acid Oxidoreductases; Colorimetry; Indophenol; Kynurenine; Methylene Blue; Oxygen Consumption; Pseudomonas; Spectrophotometry; Tryptophan | 1966 |
Correlation of kynurenine excretion with liver tryptophan pyrrolase levels in disease and after hydrocortisone induction.
Topics: Adolescent; Adult; Aged; Animals; Female; Humans; Hydrocortisone; Kynurenine; Liver; Male; Middle Aged; Oxygenases; Pyridoxine; Rats; Tryptophan; Tryptophan Oxygenase | 1966 |
Nonenzymatic cleavage of tryptophyl peptide bonds in peptides and proteins. I. Cleavage of C-tryptophyl peptide bonds in model peptides through their conversion into N-formyl-kynurenine derivatives.
Topics: Chemical Phenomena; Chemistry; Formates; Kynurenine; Peptides; Tryptophan | 1966 |
Inhibition of inducible liver enzymes by endotoxin and actinomycin D.
Topics: Adrenalectomy; Animals; Cortisone; Dactinomycin; Endotoxins; Enzymes; In Vitro Techniques; Kynurenine; Liver; Mice; Oxygenases; Subcellular Fractions; Transaminases; Tryptophan | 1966 |
Urinary tryptophan metabolites in rheumatoid arthritis and some other diseases.
Topics: Arthritis, Rheumatoid; Female; Humans; Hyaluronic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Xanthurenates | 1966 |
The influence of oestrogens on tryptophan metabolism in man.
Topics: Adult; Aged; Chromatography; Ethinyl Estradiol; Ethynodiol Diacetate; Female; Humans; Kynurenine; Male; Mestranol; Middle Aged; Norethindrone; Norethynodrel; ortho-Aminobenzoates; Progestins; Pyridoxine; Tryptophan; Xanthurenates | 1966 |
Metabolism of D-tryptophan by a species of Flavobacterium.
Topics: Flavobacterium; Kynurenine; ortho-Aminobenzoates; Tryptophan | 1966 |
[A new method for the identification of tryptophan metabolites: thin layer chromatography].
Topics: Child; Child, Preschool; Chromatography, Thin Layer; Humans; Kynurenic Acid; Kynurenine; Tryptophan; Xanthurenates | 1966 |
Determination of tryptophan derivatives by thin-layer chromatography.
Topics: Chromatography, Thin Layer; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Solvents; Spectrophotometry; Tryptophan; Xanthurenates | 1966 |
[Tryptophan and its metabolites in radiobiology and in radiation protection].
Topics: Animals; Carboxy-Lyases; Kynurenine; Liver; Mice; Mixed Function Oxygenases; Oxidoreductases; Radiation Protection; Serotonin; Tryptophan; Vitamin B 6 Deficiency | 1966 |
A survey of the urinary output of kynurenine and 3-hydroxykynurenine in various pathological states.
Topics: Adult; Aged; Chromatography, Ion Exchange; Chromatography, Paper; Female; Humans; Kynurenine; Male; Middle Aged; Tryptophan | 1966 |
A study of tryptophan metabolism in psychotic children.
Topics: Autoradiography; Carbon Isotopes; Child; Child, Preschool; Female; Humans; Kynurenine; Male; Metabolic Diseases; ortho-Aminobenzoates; Pyridoxal Phosphate; Pyridoxine; Schizophrenia, Childhood; Tryptophan; Xanthurenates | 1966 |
[Studies on biological radiation protection. 76. Activity of tryptophan and kynurenine hydroxylases in the liver of mice following irradiation in vivo and their modification by 5-hydroxytryptamine].
Topics: Animals; Cytoplasm; Female; Histocytochemistry; Kynurenine; Liver; Mice; Mixed Function Oxygenases; Radiation Effects; Radiation-Protective Agents; Serotonin; Tryptophan | 1966 |
[Studies of biological radiation protection. 77. The effect of 5-hydroxytryptamine on enzymatic changes in tryptophan metabolism caused by irradiation].
Topics: Animals; Female; Hydrolases; Injections, Intraperitoneal; Kynurenine; Liver; Mice; Radiation Effects; Radiation-Protective Agents; Serotonin; Transaminases; Tryptophan; Tryptophan Oxygenase | 1966 |
Tryptophan metabolism in normal and phenylketonuric rats.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Humans; Indoleacetic Acids; Injections, Intravenous; Kynurenine; Male; Phenylalanine; Phenylketonurias; Rats; Tryptophan; Urea | 1966 |
Hydroxykynureninuria.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Female; Growth; Humans; Infant, Newborn; Intelligence Tests; Kynurenic Acid; Kynurenine; Kyphosis; Nicotinic Acids; Pyridoxine; Tryptophan; Xanthurenates | 1967 |
Urine composition in the etiology of bladder tumor formation.
Topics: Carcinogens; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Urinary Bladder Neoplasms; Urine | 1967 |
Vitamin B6 nutriture studied in obese subjects during 8 weeks of starvation.
Topics: Female; Humans; Kynurenic Acid; Kynurenine; Male; Obesity; Oxalates; Pyridoxine; Starvation; Transaminases; Tryptophan; Xanthurenates | 1967 |
Tryptophan metabolism. A hitherto unreported abnormality occurring in a family.
Topics: Chlorotrianisene; Electroencephalography; Female; Humans; Injections, Intramuscular; Kynurenine; Male; Metabolism, Inborn Errors; Pyridoxine; Scleroderma, Systemic; Tryptophan | 1967 |
Effects of loading with tryptophan metabolites on metabolism of DL-tryptophan-7a-C14 in rats.
Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Kynurenine; ortho-Aminobenzoates; Pyridines; Rats; Tryptophan | 1967 |
Biochemical and physiological changes in vitamin B6 deficiency.
Topics: Alanine Transaminase; Anemia, Hypochromic; Central Nervous System Diseases; Cysteine; Erythrocytes; Humans; Kynurenic Acid; Kynurenine; Male; Nicotinic Acids; Pyridoxal Phosphate; Pyridoxine; Serotonin; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1967 |
Localization of non-essential tryptophan residues for the biological activity of lysozyme.
Topics: Amino Acids; Egg White; Formates; In Vitro Techniques; Kynurenine; Muramidase; Ozone; Spectrophotometry; Trypsin; Tryptophan | 1967 |
Catabolism of tryptophan by the isolated, perfused liver and intestine.
Topics: Animals; Carbon Isotopes; Chromatography, Paper; In Vitro Techniques; Intestinal Mucosa; Kynurenine; Liver; Rats; Tritium; Tryptophan | 1967 |
The degradation of tryptophan during paper chromatography with observations on some metabolites of tryptophan.
Topics: Autoradiography; Carbon Isotopes; Chromatography, Paper; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Ultraviolet Rays; Xanthurenates | 1967 |
Enzymatic studies on the hydroxylation of kynurenine in Drosophila melanogaster.
Topics: Amidohydrolases; Coenzymes; Drosophila; Kynurenine; Mitochondria; Mixed Function Oxygenases; Mutation; Oxygenases; Pigmentation; Pteridines; Tryptophan | 1967 |
The isolation and identification of 5-hydroxy-L-kynurenine from the urine of hens.
Topics: Animals; Chromatography, Paper; Chromatography, Thin Layer; Female; Kynurenine; Poultry; Spectrophotometry; Transaminases; Tryptophan | 1967 |
Studies with tryptophan metabolites in vitro. Kynurenine metabolism in liver homogenates of normal and Schistosoma mansoni-infested mice.
Topics: Animals; Kinetics; Kynurenine; Liver; Mice; ortho-Aminobenzoates; Perfusion; Pyridoxal Phosphate; Pyridoxine; Schistosomiasis; Tryptophan | 1967 |
On the determination of small amounts of tryptophan metabolites and their occurrence in normal human urine.
Topics: Adult; Aminohippuric Acids; Chromatography, Ion Exchange; Chromatography, Paper; Colorimetry; Female; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1967 |
[Study of tryptophan metabolism in various hepato-digestive diseases. I. Viral hepatitis].
Topics: Amino Acids; Aspartate Aminotransferases; Blood Chemical Analysis; Hepatitis A; Humans; Kynurenine; Tryptophan | 1967 |
[Specific non-enzymatic cleavage of polypeptide chains at the level of tyrosine].
Topics: Chemical Phenomena; Chemistry; Kynurenine; Ozone; Peptides; Pyrrolidines; Spectrophotometry; Tryptophan; Tyrosine | 1967 |
Effect of protein intake on the development of abnormal tryptophan metabolism by men during vitamin B6 depletion.
Topics: Adult; Body Weight; Dietary Proteins; Humans; Kynurenic Acid; Kynurenine; Male; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1967 |
The acetylation of tryptophan metabolites by rapid and slow acetylators of sulfamethazine.
Topics: Acetates; Chromatography, Paper; Genetics, Medical; Humans; Kynurenine; Molecular Biology; Sulfamethazine; Tryptophan | 1967 |
[Study of the metabolism of tryptophane in various hepato-intestinal diseases. II. Frequency of anomalies in neoplastic diseases].
Topics: Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Kynurenine; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Riboflavin Deficiency; Tryptophan; Vitamin B 6 Deficiency | 1967 |
Adrenal cortical activity changes in manic-depressive illness. Influence on intermediary metabolism of tryptophan.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Bipolar Disorder; Carbon Isotopes; Female; Humans; Kynurenine; Middle Aged; Pituitary-Adrenal Function Tests; Statistics as Topic; Tryptophan; Tryptophan Oxygenase | 1967 |
The inhibition of tryptophan pyrrolase by allopurinol, an inhibitor of xanthine oxidase.
Topics: Allopurinol; Animals; Female; Kinetics; Kynurenine; Liver; Rats; Tryptophan; Tryptophan Oxygenase; Xanthine Oxidase | 1967 |
Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.
Topics: Amidohydrolases; Ascorbic Acid; Carbon Monoxide; Catalysis; Cyanides; Heme; Intestine, Small; Intestines; Kinetics; Kynurenine; Light; Methylene Blue; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1967 |
Resolution of optical isomers of kynurenine and its derivatives by thin-layer chromatography.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Kynurenine; Rats; Solvents; Tryptophan | 1967 |
Tryptophan metabolism in experimental porphyria.
Topics: Animals; Chromatography; Kynurenine; Liver; Male; Porphyrias; Rats; Tryptophan; Tryptophan Oxygenase | 1967 |
Observations on nicotinic acid therapy in Hartnup disease.
Topics: Hartnup Disease; Humans; Indican; Indoleacetic Acids; Kidney; Kynurenine; Nicotinic Acids; Renal Aminoacidurias; Tryptophan | 1967 |
Estimation of the tryptophan metabolites xanthurenic acid, 3-hydroxykynurenine and kynurenine.
Topics: Colorimetry; Darkness; Drug Stability; Hydrogen-Ion Concentration; Indicators and Reagents; Kynurenine; Methods; Oxidation-Reduction; Tryptophan; Xanthurenates | 1967 |
Regulation of tryptophan metabolism in the parasitic wasp, Habrobracon juglandis.
Topics: Animals; Insecta; Kynurenic Acid; Kynurenine; Molecular Biology; Mutation; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1967 |
On the localization of tryptophan in the alpha-3 chain of collagen.
Topics: Amino Acid Sequence; Collagen; Kynurenine; Ozone; Peptides; Trypsin; Tryptophan | 1967 |
Studies on tryptophan metabolism in malignant tumor.
Topics: Animals; Chromatography, Paper; Humans; Kynurenine; Mucoproteins; Neoplasms; Radiation Effects; Rats; Sarcoma, Yoshida; Tryptophan | 1967 |
The stability of tryptophan metabolites prior to urine analysis.
Topics: 5-Hydroxytryptophan; Animals; Chromatography, High Pressure Liquid; Cold Temperature; Drug Stability; Humans; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Rats; Serotonin; Tryptophan | 1980 |
[Current biochemical conceptions of mental diseases. II. Role of changes in the biogenic amine system in the pathogenesis of affective disorders].
Topics: 3-Methoxy-4-hydroxyphenylethanol; Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar Disorder; Brain; Catechol O-Methyltransferase; Cyclic AMP; Depression; Dopamine; Dopamine beta-Hydroxylase; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kynurenine; Monoamine Oxidase Inhibitors; Norepinephrine; Receptors, Dopamine; Reserpine; Serotonin; Tryptophan | 1980 |
The functional importance of increased brain tryptophan in the serotonergic response to restraint stress.
Topics: Animals; Brain; Corticosterone; Hydroxyindoleacetic Acid; Kynurenine; Male; Rats; Serotonin; Stress, Physiological; Tryptophan; Valine | 1981 |
Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.
Topics: Adolescent; Adult; Aged; Amino Acids; Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Humans; Hydroxyindoleacetic Acid; Kynurenine; Middle Aged; Tryptophan | 1983 |
Effect of amino acid metabolites on lysosomal protein degradation. A regulatory role for kynurenine?
Topics: alpha-Fetoproteins; Amino Acids; Animals; Asialoglycoproteins; Fetuins; Histidine; In Vitro Techniques; Kynurenine; Liver; Male; Microscopy, Electron; Phenylalanine; Proteins; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine | 1984 |
Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects.
Topics: Adult; Female; Humans; Kidney; Kinetics; Kynurenine; Male; Niacinamide; Tryptophan; Tryptophan Oxygenase | 1981 |
The effects of a dietary excess of leucine on the synthesis of nicotinamide nucleotides in the rat.
Topics: Animals; Diet; Enzyme Activation; Hydrolases; Kynurenine; Leucine; Liver; Male; NADP; Niacin; Niacinamide; Pellagra; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1983 |
The kinetic mechanism of inhibition of liver pyridoxal kinase with tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Animals; Kinetics; Kynurenine; Liver; Phosphotransferases; Pyridoxal Kinase; Quinolinic Acids; Sheep; Tryptophan; Xanthurenates | 1981 |
[Determination of urinary xanthurenic acid after oral loading of L-tryptophan in 88 cases of photodermatosis].
Topics: Administration, Oral; Adolescent; Adult; Aged; Child; Female; Humans; Hydroa Vacciniforme; Kynurenic Acid; Kynurenine; Male; Middle Aged; Photosensitivity Disorders; Pyridoxine; Tryptophan; Xanthurenates | 1984 |
The endopeptidase-resistant protein fraction from human cataractous lenses.
Topics: Amino Acids; Cataract; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Crystallins; Endopeptidases; Humans; In Vitro Techniques; Kynurenine; Oxindoles; Spectrophotometry; Tryptophan | 1984 |
A method for the synthesis of [14C]-kynurenine.
Topics: beta-Alanine; Hydrolases; Kynurenine; Pseudomonas; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan | 1984 |
Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Lyases; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Transaminases; Tryptophan; Vitamin B 6 Deficiency | 1984 |
Analytical methodology for assays of serum tryptophan metabolites in control subjects and newly abstinent alcoholics: preliminary investigation by liquid chromatography with amperometric detection.
Topics: Adult; Aged; Alcoholism; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Kynurenine; Male; Middle Aged; Serotonin; Spectrophotometry, Ultraviolet; Substance Withdrawal Syndrome; Tryptophan | 1984 |
[Changes in the metabolism of tryptophan in erythematosus].
Topics: Adult; Aged; Female; Humans; Kynurenine; Lupus Erythematosus, Discoid; Male; Middle Aged; Sex Factors; Tryptophan; Xanthurenates | 1984 |
[Tryptophan metabolism in syphilis infections].
Topics: Adult; Female; Humans; Kynurenine; Male; Middle Aged; Syphilis; Tryptophan; Xanthurenates | 1984 |
Regulation of cerebral kynurenine and 5-hydroxyindole pathways during tryptophan loading.
Topics: Animals; Brain; Dipeptides; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Oxygenases; Rats; Serotonin; Tryptophan; Tryptophan Hydroxylase; Tryptophan Oxygenase | 1983 |
Photolytic changes in lens proteins.
Topics: Adolescent; Aged; Aging; Animals; Cataract; Cattle; Crystallins; Glucosides; Humans; In Vitro Techniques; Kynurenine; Lens, Crystalline; Photochemistry; Photolysis; Tryptophan | 1984 |
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism.
Topics: Acrodermatitis; Adolescent; Child; Female; Humans; Intestinal Diseases; Kynurenine; Male; Picolinic Acids; Tryptophan; Zinc | 1984 |
[Tryptophan metabolism in children with epilepsy].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Kynurenine; Male; Pyridoxine; Tryptophan | 1984 |
[Effect of mutations blocking the kynurenine pathway of tryptophan metabolism on neural activity in Drosophila melanogaster].
Topics: Animals; Drosophila melanogaster; Electrophysiology; Female; Kynurenine; Mutation; Nervous System Physiological Phenomena; Tryptophan | 1981 |
Tryptophan tolerance and metabolism in endogenous depression.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Kinetics; Kynurenine; Metabolic Clearance Rate; Middle Aged; Tryptophan | 1982 |
The role of the single tryptophan residue in the structure and function of ribonuclease T1.
Topics: Binding Sites; Guanidine; Guanidines; Kinetics; Kynurenine; Oxidation-Reduction; Protein Binding; Ribonuclease T1; Ribonucleases; Spectrometry, Fluorescence; Tryptophan | 1982 |
Binding between thermolysin and talopeptin (MKI) in which the tryptophan residue was converted into kynurenine.
Topics: Biotransformation; Energy Metabolism; Glycopeptides; Hydrogen-Ion Concentration; Kinetics; Kynurenine; Protein Binding; Spectrometry, Fluorescence; Thermolysin; Tryptophan | 1983 |
Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma.
Topics: Animals; Hydrolases; Kynurenine; Lyases; Melanoma; Mice; Neoplasm Transplantation; Transaminases; Tryptophan; Tryptophan Oxygenase | 1983 |
Analysis of corticosteroids in human adrenal tissue by high pressure liquid chromatography.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenal Glands; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Cushing Syndrome; Humans; Hyperaldosteronism; Indoles; Kynurenine; Tryptophan | 1983 |
Activation of tryptophan pyrrolase after chronic alcohol administration.
Topics: Alcoholism; Animals; Enzyme Activation; Humans; Kynurenine; Liver; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1982 |
Urinary tryptophan metabolites and cancer of the bladder in humans.
Topics: Adult; Age Factors; Aged; Aminohippuric Acids; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sex Factors; Smoking; Tryptophan; Urinary Bladder Neoplasms | 1981 |
Metabolism and serum levels of tryptophan in senile cataract patients.
Topics: Age Factors; Aged; Cataract; Female; Humans; Kynurenine; Male; Middle Aged; Sex Factors; Tryptophan | 1982 |
Tryptophan lens levels in senile cataract.
Topics: Aged; Cataract; Female; Humans; Kynurenine; Lens, Crystalline; Male; Middle Aged; Oxidation-Reduction; Photochemistry; Tryptophan | 1982 |
Effect of exposure to light in enzyme activities and tryptophan metabolites of the kynurenine pathway in Wistar, in heterozygous and homozygous adult and newborn Gunn rats.
Topics: Aging; Animals; Animals, Newborn; Female; Heterozygote; Hydrolases; Kynurenine; Light; Liver; Lyases; Male; Rats; Rats, Inbred Strains; Species Specificity; Transaminases; Tryptophan; Tryptophan Oxygenase | 1982 |
Induction of ornithine decarboxylase activity in mouse urinary bladder by L-tryptophan and some of its metabolites.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Diet; Enzyme Induction; Epithelium; Female; Hyperplasia; Kynurenic Acid; Kynurenine; Ornithine Decarboxylase; ortho-Aminobenzoates; Quinolines; Stereoisomerism; Tryptophan; Urinary Bladder; Xanthurenates | 1982 |
Fluorescence characteristics of kynurenine and N'-formylkynurenine. Their use as reporters of the environment of tryptophan 62 in hen egg-white lysozyme.
Topics: Animals; Binding Sites; Chickens; Egg White; Kinetics; Kynurenine; Muramidase; Protein Binding; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 1982 |
Alterations of the tryptophan--nicotinic acid metabolism in vitiligo.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Melanins; Mixed Function Oxygenases; Models, Biological; Niacin; Tryptophan; Vitiligo; Xanthurenates | 1982 |
Catabolism of tryptophan, anthranilate, and 2,3-dihydroxybenzoate in Trichosporon cutaneum.
Topics: Carboxy-Lyases; Catechols; Hydroxybenzoates; Kynurenine; Mitosporic Fungi; Mixed Function Oxygenases; ortho-Aminobenzoates; Salicylates; Tryptophan | 1981 |
Short-term and repetitive administration of oral tryptophan in normal men. Effects on blood tryptophan, serotonin, and kynurenine concentrations.
Topics: Administration, Oral; Adult; Arousal; Attention; Dose-Response Relationship, Drug; Humans; Kynurenine; Male; Middle Aged; Protein Binding; Serotonin; Tryptophan | 1981 |
Tryptophan metabolism in children with attentional deficit disorder.
Topics: Adolescent; Adult; Attention; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Child; Child, Preschool; Dextroamphetamine; Humans; Intelligence; Kynurenine; Methylphenidate; Protein Binding; Serotonin; Tryptophan | 1981 |
Metabolism of tryptophan by Pseudomonas aureofaciens and its relationship to pyrrolnitrin biosynthesis.
Topics: Antifungal Agents; Enzyme Induction; Glycerol; Indoleacetic Acids; Kynurenine; ortho-Aminobenzoates; Pseudomonas; Pyrrolnitrin; Tryptophan; Tryptophan Oxygenase | 1980 |
Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression.
Topics: Adult; Brain Chemistry; Contraceptives, Oral; Contraceptives, Oral, Combined; Depressive Disorder; Ethinyl Estradiol; Female; Humans; Kynurenine; Mestranol; Norethindrone; Norethindrone Acetate; Tryptophan; Tyrosine | 1981 |
Effect of psoralen-induced photodermatitis on tryptophan metabolism in guinea pigs.
Topics: Animals; Female; Furocoumarins; Guinea Pigs; Hydrolases; Kynurenine; Liver; Lyases; Photosensitivity Disorders; Transaminases; Tryptophan; Tryptophan Oxygenase | 1981 |
Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis.
Topics: Animals; Brain; Brain Chemistry; Enzyme Induction; Hydrocortisone; Kynurenine; Liver; Male; Rats; Rats, Inbred Strains; Serotonin; Tryptophan; Tryptophan Oxygenase | 1981 |
[Tryptophan metabolism in psoriasis].
Topics: Adult; Chronic Disease; Circadian Rhythm; Female; Humans; Kynurenine; Male; Middle Aged; Psoriasis; Tryptophan; Xanthurenates | 1981 |
Enzyme activities of tryptophan metabolism in heterozygous and homozygous Gunn rats before and after blue light exposure.
Topics: Animals; Female; Heterozygote; Homozygote; Hydrolases; Kidney; Kynurenine; Liver; Lyases; Male; Photic Stimulation; Rats; Rats, Gunn; Rats, Mutant Strains; Transaminases; Tryptophan; Tryptophan Oxygenase | 1981 |
Effect of natural oestrogens on tryptophan metabolism: evidence for interference of oestrogens with kynureninase.
Topics: Aged; Estradiol; Estriol; Estrogens; Female; Humans; Hydrolases; Kynurenine; Menopause; Middle Aged; NAD; Pyridoxal Phosphate; Pyridoxic Acid; Pyridoxine; Tryptophan | 1980 |
The kynurenine load test, an adjunct to the tryptophan load test.
Topics: 3-Hydroxyanthranilic Acid; Aged; Female; Humans; Kynurenine; Menopause; Middle Aged; NAD; Pyridoxine; Tryptophan | 1980 |
Comparison of high-performance liquid chromatographic serum profiles of humans and dogs.
Topics: Animals; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Creatinine; Dogs; Humans; Hypoxanthines; Inosine; Kynurenine; Male; Nucleosides; Purines; Tryptophan; Tyrosine; Uric Acid; Xanthines | 1980 |
Binding of substrate analogs to hen lysozyme in which Trp 62 is modified to kynurenine.
Topics: Animals; Binding Sites; Chickens; Circular Dichroism; Egg White; Female; Hydrogen-Ion Concentration; Kinetics; Kynurenine; Muramidase; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Tryptophan | 1980 |
Hydroxykynurenine/hydroxyanthranilic acid ratios and febrile convulsions.
Topics: 3-Hydroxyanthranilic Acid; Child, Preschool; Humans; Infant; Kynurenine; ortho-Aminobenzoates; Seizures; Seizures, Febrile; Time Factors; Tryptophan | 1980 |
Isolation and characterization of a mutant of Pseudomonas aureofaciens ATCC 15926 with an increased capacity for synthesis of pyrrolnitrin.
Topics: Antifungal Agents; Kynurenine; Methylnitronitrosoguanidine; Mutation; ortho-Aminobenzoates; Pseudomonas; Pyrrolnitrin; Tryptophan | 1980 |
The effect of drugs on vitamin B6 function in the rat.
Topics: Animals; In Vitro Techniques; Isoniazid; Kynurenine; Lyases; Male; Pyridoxal Phosphate; Pyridoxine; Rats; Transaminases; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1980 |
Effect of psoralen-induced photodermatitis on tryptophan metabolism in rats.
Topics: Animals; Ficusin; Hydrolases; Kidney; Kynurenine; Liver; Lyases; Male; Photosensitivity Disorders; Rats; Transaminases; Tryptophan; Tryptophan Oxygenase | 1981 |
Functions of the white and topaz loci of Lucilia cuprina in the production of the eye pigment xanthommatin.
Topics: Animals; Diptera; Eye Color; In Vitro Techniques; Kynurenine; Larva; Malpighian Tubules; Mutation; Retinal Pigments; Tritium; Tryptophan; Water | 1980 |
Tryptophan metabolism in chronic inflammatory lung disease.
Topics: Actins; Adult; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Chronic Disease; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocyte Count; Lung Diseases, Interstitial; Macrophages; Male; Middle Aged; RNA, Messenger; Sarcoidosis; Smoking; Synovitis; Tryptophan; Tryptophan Oxygenase | 1995 |
Structural requirements for altering the L-tryptophan metabolism in mice by organophosphorous and methylcarbamate insecticides.
Topics: Animals; Arylformamidase; Carbamates; Insecticides; Kynurenine; Liver; Male; Mice; Organophosphorus Compounds; Structure-Activity Relationship; Tryptophan; Xanthurenates | 1993 |
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Thinness; Tryptophan | 1995 |
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan | 1995 |
Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6.
Topics: Animals; Diet; Female; Hydrolases; Kynurenine; Liver; Lyases; Mice; Mice, Inbred A; Mice, Inbred DBA; Pregnancy; Pregnancy, Animal; Pyridoxine; Transaminases; Tryptophan | 1995 |
Concentrations of serotonin and its related substances in the cerebrospinal fluid of parkinsonian patients and their relations to the severity of symptoms.
Topics: 5-Hydroxytryptophan; Humans; Hydroxyindoleacetic Acid; Kynurenine; Middle Aged; Parkinson Disease; Reference Values; Serotonin; Tryptophan | 1993 |
Tryptophan 2,3-dioxygenase in Saccharomyces cerevisiae.
Topics: Azides; Binding Sites; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Fungal Proteins; Heme; Hydrogen-Ion Concentration; Isoelectric Point; Kynurenine; Potassium Cyanide; Saccharomyces cerevisiae; Sodium Azide; Substrate Specificity; Tryptophan; Tryptophan Oxygenase | 1995 |
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates | 1995 |
Gourami lenses convert tryptophan into 3-hydroxykynurenine.
Topics: Animals; Chromatography, High Pressure Liquid; Fishes; Kynurenine; Lens, Crystalline; Organ Culture Techniques; Tryptophan | 1994 |
The role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-gamma in vivo.
Topics: Adult; Aged; Animals; Blotting, Northern; Enzyme Induction; Female; Humans; In Situ Hybridization; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Ovarian Neoplasms; Recombinant Proteins; RNA, Messenger; Transplantation, Heterologous; Tryptophan; Tryptophan Oxygenase; Tryptophan-tRNA Ligase; Tumor Cells, Cultured | 1995 |
6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Immune System; Kynurenine; Lung; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1994 |
Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Animals; Autoradiography; Base Sequence; Carcinogens; Cattle; Cells, Cultured; Copper; DNA; DNA Damage; Free Radical Scavengers; Genes, ras; Humans; Indicators and Reagents; Kynurenine; Manganese Poisoning; Molecular Sequence Data; Oxidation-Reduction; Phenanthrolines; Phosphorus Radioisotopes; Spectrophotometry, Ultraviolet; Tryptophan | 1995 |
Neopterin production and tryptophan degradation in acute Lyme neuroborreliosis versus late Lyme encephalopathy.
Topics: Acute Disease; Adult; Aged; Biopterins; Borrelia Infections; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Nervous System Diseases; Tryptophan | 1994 |
Inflammation-associated changes in the cellular availability of tryptophan and kynurenine in renal transplant recipients.
Topics: Analysis of Variance; Blood Proteins; Graft Rejection; Humans; Kidney Transplantation; Kynurenine; Muromonab-CD3; Nephritis; Protein Binding; Retrospective Studies; Tryptophan | 1994 |
Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Chromatography, High Pressure Liquid; Glucosides; Humans; Kynurenine; Lens, Crystalline; Middle Aged; Organ Culture Techniques; Tryptophan | 1994 |
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.
Topics: Alanine; Animals; Anticonvulsants; Binding, Competitive; Brain; Hippocampus; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Motor Activity; Rats; Seizures; Tryptophan | 1994 |
Quantification of L-tryptophan and L-kynurenine by liquid chromatography/electron capture negative ion chemical ionization mass spectrometry.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fluorobenzenes; Gerbillinae; Glioblastoma; Humans; In Vitro Techniques; Interferon-gamma; Kynurenine; Lung; Mass Spectrometry; Mice; Mice, Inbred C57BL; Monocytes; Nervous System Neoplasms; Reference Standards; Spectrophotometry, Ultraviolet; Tryptophan; Tumor Cells, Cultured | 1994 |
Elevated plasma kynurenine in Tourette syndrome.
Topics: Adolescent; Adult; Biopterins; Child; Female; Humans; Kynurenine; Male; Neopterin; Reference Values; Tourette Syndrome; Tryptophan | 1994 |
Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway.
Topics: 3-Hydroxyanthranilic Acid; Cholesterol Esters; Dose-Response Relationship, Drug; Enzyme Induction; Fatty Acids, Unsaturated; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Lipoproteins, LDL; Onium Compounds; Oxidation-Reduction; Peroxides; Tryptophan; Tryptophan Oxygenase; Vitamin E | 1994 |
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Carbon Isotopes; Dioxygenases; Female; Gerbillinae; Hydrolases; Ischemic Attack, Transient; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Lyases; Lymphocyte Activation; Mitochondria; Mixed Function Oxygenases; Organ Specificity; Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Synaptosomes; Transaminases; Tryptophan; Tryptophan Oxygenase | 1993 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1993 |
Assay of tryptophan 2,3-dioxygenase using liver slices and high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Kinetics; Kynurenine; Liver; Male; Mice; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1993 |
Production of [14C]-labeled 3-hydroxy-L-kynurenine in a butterfly, Heliconius charitonia L. (Heliconidae), and precursor studies in butterfly wing ommatins.
Topics: Amino Acids; Animals; Butterflies; Chromatography, Thin Layer; Kynurenine; Oxazines; Pigments, Biological; Pupa; Tryptophan; Wings, Animal; Xanthenes | 1993 |
Skin L-tryptophan-2,3-dioxygenase and rat hair growth.
Topics: Animals; Cycloheximide; Hair; Kynurenine; Liver; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seasons; Skin; Tryptophan; Tryptophan Oxygenase | 1993 |
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Female; Gerbillinae; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Macrophages; Pokeweed Mitogens; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase | 1993 |
Weight loss in patients with hematological neoplasias is associated with immune system stimulation.
Topics: Biomarkers; Biopterins; Cachexia; Female; Follow-Up Studies; Humans; Immunity, Cellular; Interferon-gamma; Kynurenine; Lymphoma; Male; Multiple Myeloma; Neopterin; Tryptophan; Weight Loss | 1993 |
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Carbolines; Cell Line; Harmine; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Macrophages; Quinolinic Acid; Rats; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
UV filters in human lenses: tryptophan catabolism.
Topics: Aged; Aged, 80 and over; Child, Preschool; Chromatography, High Pressure Liquid; Filtration; Glucosides; Humans; Kynurenine; Lens, Crystalline; Middle Aged; Organ Culture Techniques; Tryptophan; Ultraviolet Rays | 1993 |
Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3-dioxygenase.
Topics: Animals; Cells, Cultured; Cloning, Molecular; Enzyme Induction; In Vitro Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metallothionein; Mice; Promoter Regions, Genetic; Toxoplasma; Toxoplasmosis, Animal; Transfection; Tryptophan; Tryptophan Oxygenase; Zinc | 1993 |
Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Cataract; Fasting; Female; Humans; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1995 |
Steady-state and time-resolved fluorescence studies on the ligand-induced conformational change in an active lysozyme derivative, Kyn62-lysozyme.
Topics: Acetylglucosamine; Animals; Binding Sites; Chickens; Energy Transfer; In Vitro Techniques; Kynurenine; Ligands; Muramidase; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Tryptophan | 1996 |
Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice.
Topics: Animals; Brain; Enzyme Inhibitors; Indoles; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1996 |
Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection.
Topics: Chromatography, High Pressure Liquid; Humans; Kynurenine; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 1996 |
Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.
Topics: Cells, Cultured; DNA, Viral; Human T-lymphotropic virus 1; Humans; Interferon-gamma; Kynurenine; Macrophages; Monocytes; Neuroimmunomodulation; Polymerase Chain Reaction; Proviruses; Quinolinic Acid; Tryptophan | 1996 |
[Comparison of free non-tryptophan fluorescent substances in water-soluble fraction of brunescent and non-brunescent human cataract].
Topics: Cataract; Chromatography, High Pressure Liquid; Fluorescence; Glucosides; Humans; Kynurenine; Lens, Crystalline; Solubility; Tryptophan | 1996 |
Decreased plasma tryptophan in pregnancy.
Topics: Biopterins; Female; Humans; Kynurenine; Neopterin; Postpartum Period; Pregnancy; Tryptophan | 1996 |
Effects of tryptophan load on amino acid metabolism in type 1 diabetic patients.
Topics: Adult; Amino Acids; Analysis of Variance; Case-Control Studies; Diabetes Mellitus, Type 1; Female; Humans; Kynurenine; Male; Tryptophan | 1996 |
Formation of N-formylkynurenine suggests the involvement of apolipoprotein B-100 centered tryptophan radicals in the initiation of LDL lipid peroxidation.
Topics: Apolipoproteins B; Chromatography, High Pressure Liquid; Copper; Free Radicals; Humans; Kynurenine; Lipid Peroxidation; Lipoproteins, LDL; Oxidation-Reduction; Pronase; Tryptophan | 1996 |
Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Clone Cells; Dioxygenases; Enzyme Induction; Humans; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Kynurenine 3-Monooxygenase; Lyases; Macrophages; Mice; Microglia; Mixed Function Oxygenases; Oxygenases; Transaminases; Tryptophan; Tryptophan Oxygenase | 1996 |
[Activity of the motoneurons of the flight muscles in Drosophila with mutations in the kynurenine pathway of tryptophan metabolism].
Topics: Animals; Drosophila; Female; Kynurenine; Microelectrodes; Motor Neurons; Muscles; Mutation; Tryptophan; Wings, Animal | 1995 |
Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye.
Topics: Aged; Aged, 80 and over; Antioxidants; Chromatography, High Pressure Liquid; Ciliary Body; Eye; Humans; Hydroxylation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iris; Kynurenine; Kynurenine 3-Monooxygenase; Lens, Crystalline; Mixed Function Oxygenases; Retina; Tryptophan; Tryptophan Oxygenase | 1996 |
Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome.
Topics: Adolescent; Adult; Child; Female; Humans; Kynurenine; Male; Plasma; Pteridines; Tourette Syndrome; Tryptophan | 1996 |
Congenital non-progressive encephalopathy and deafness with intermittent episodes of coma and hyperkynureninuria.
Topics: Algeria; Brain Diseases; Child; Child, Preschool; Coma; Deafness; Female; Humans; Infant; Intellectual Disability; Kynurenine; Male; Pedigree; Renal Aminoacidurias; Tryptophan | 1996 |
Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/lymphoma.
Topics: Adult; beta 2-Microglobulin; Biomarkers; Biopterins; Cross-Sectional Studies; Female; Forecasting; HTLV-I Antibodies; Humans; Jamaica; Kynurenine; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Neopterin; Paraparesis, Tropical Spastic; Pilot Projects; Proportional Hazards Models; Seroepidemiologic Studies; Survival Rate; Tryptophan | 1996 |
Tyrosine and tryptophan derivatives in pig lumbar cerebrospinal fluid. Effects of subchronic administration of dopa associated with benserazide.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Benserazide; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Kynurenine; Levodopa; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Swine; Tryptamines; Tryptophan; Tyrosine | 1996 |
Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy.
Topics: Anti-HIV Agents; Biopterins; Chromatography, High Pressure Liquid; HIV Infections; HIV Seropositivity; Humans; Kynurenine; Neopterin; Quinolinic Acid; Radioimmunoassay; Time Factors; Tryptophan; Zidovudine | 1996 |
Activated cellular immunity and decreased serum tryptophan in healthy pregnancy.
Topics: Biopterins; Chromatography, High Pressure Liquid; Female; Gestational Age; Humans; Immunity, Cellular; Kynurenine; Neopterin; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Reference Values; Tryptophan | 1996 |
The effects of induced kynurenine pathway on immunocytochemical changes in rat tissues following excessive L-tryptophan consumption.
Topics: Animals; Brain; Female; Fenclonine; Food, Fortified; Immunohistochemistry; Kynurenine; Lung; Muscle, Skeletal; Rats; Serotonin; Tryptophan; Tumor Necrosis Factor-alpha; Weight Gain | 1996 |
Serum tryptophan, kynurenine, and neopterin in patients with Guillain-Barre-syndrome (GBS) and multiple sclerosis (MS).
Topics: Biopterins; Humans; Kynurenine; Multiple Sclerosis; Neopterin; Polyradiculoneuropathy; Reference Values; Time Factors; Tryptophan | 1996 |
Regulation of quinolinic acid in the normal rat brain by kynurenine pathway precursors.
Topics: 3-Hydroxyanthranilic Acid; Analysis of Variance; Animals; Cerebral Ventricles; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan | 1996 |
Macrophages modulate liver cell function via tryptophan metabolites.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cells, Cultured; Kynurenine; Liver; Liver Glycogen; Macrophages; Mice; Mice, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1996 |
The relationship between kynurenine, catecholamines, and arterial hypertension in mesangioproliferative glomerulonephritis.
Topics: Blood Pressure; Catecholamines; Diastole; Dopamine; Epinephrine; Glomerulonephritis, Membranoproliferative; Humans; Hypertension; Kynurenine; Norepinephrine; Reference Values; Systole; Tryptophan | 1996 |
Is an altered tryptophan metabolism responsible for age-related cataract?
Topics: 3-Hydroxyanthranilic Acid; Aged; Cataract; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Reference Values; Sensitivity and Specificity; Tryptophan | 1996 |
Fluorometric determination of L-kynurenine with glycolaldehyde by high performance liquid chromatography.
Topics: Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Indicators and Reagents; Kinetics; Kynurenine; Liver; Male; Rats; Rats, Wistar; Spectrometry, Fluorescence; Tryptophan; Tryptophan Oxygenase | 1996 |
Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys.
Topics: Animals; Antibody Specificity; Cell Size; Cells, Cultured; Immunohistochemistry; Kynurenine; Macaca mulatta; Macrophages; Monocytes; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan | 1996 |
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
Topics: Astrocytes; Brain; Carbon Isotopes; Cells, Cultured; Fetus; Humans; Interferon-gamma; Isotope Labeling; Kynurenine; Macrophages; Microglia; Neurons; Neurotoxins; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1996 |
Determination of the 8-methyl ether of xanthurenic acid in human serum by high-performance liquid chromatography with fluorescence detection.
Topics: Amino Acid Metabolism, Inborn Errors; Chromatography, High Pressure Liquid; Ethers; Humans; Kynurenine; Sensitivity and Specificity; Silicon Dioxide; Spectrometry, Fluorescence; Tryptophan; Xanthurenates | 1996 |
Elevated L-kynurenine level and its normalization by prednisolone in a patient with eosinophilia-myalgia syndrome.
Topics: Anti-Inflammatory Agents; Eosinophilia-Myalgia Syndrome; Female; Humans; Kynurenine; Middle Aged; Prednisolone; Tryptophan; Tryptophan Oxygenase | 1997 |
Photooxidation of tryptophan: O2(1 delta g) versus electron-transfer pathway.
Topics: 2,2'-Dipyridyl; Electron Transport; Fluorescent Dyes; Kinetics; Kynurenine; Organometallic Compounds; Photochemistry; Photolysis; Tryptophan | 1997 |
Oxidative modification of tryptophan residues exposed to peroxynitrite.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Collagen; Humans; Indoles; Kynurenine; Molecular Structure; Nitrates; Oxidation-Reduction; Placenta; Serum Albumin, Bovine; Spectrometry, Fluorescence; Tryptophan | 1997 |
Streptococcal erythrogenic toxins induce tryptophan degradation in human peripheral blood mononuclear cells.
Topics: Adult; Bacterial Proteins; Cells, Cultured; Exotoxins; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Membrane Proteins; Pyrogens; Streptococcus pyogenes; Superantigens; Tryptophan | 1997 |
Determination of kynurenic acid by capillary electrophoresis with laser-induced fluorescence detection.
Topics: Animals; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Osmolar Concentration; Rats; Spectrometry, Fluorescence; Time Factors; Tryptophan; Zinc | 1997 |
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Aggregation; Cells, Cultured; Coloring Agents; Fetus; HIV-1; Humans; Immunohistochemistry; Kynurenine; L-Lactate Dehydrogenase; Macrophages; Microscopy, Electron; Quinolinic Acid; Trypan Blue; Tryptophan | 1997 |
Simultaneous measurement of serum tryptophan and kynurenine by HPLC.
Topics: Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Tryptophan | 1997 |
Stimulation of NGF production by tryptophan and its metabolites in cultured mouse astroglial cells.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Kynurenine; Mice; Mice, Inbred C3H; Nerve Growth Factors; Quinolinic Acid; Serotonin; Tryptophan | 1997 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1998 |
Transamination of 3-hydroxykynurenine to produce xanthurenic acid: a major branch pathway of tryptophan metabolism in the mosquito, Aedes aegypti, during larval development.
Topics: Aedes; Animals; Kynurenine; Larva; Transaminases; Tryptophan; Xanthurenates | 1997 |
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Male; Melatonin; Seizures, Febrile; Tryptophan; Xanthurenates | 1997 |
The yeast gene YJR025c encodes a 3-hydroxyanthranilic acid dioxygenase and is involved in nicotinic acid biosynthesis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Base Sequence; Dioxygenases; Gene Deletion; Genes, Fungal; Genetic Complementation Test; Kynurenine; Molecular Sequence Data; Niacin; Oxygenases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tryptophan | 1998 |
Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS Dementia Complex; CD4 Lymphocyte Count; Female; HIV Seronegativity; Humans; Kynurenine; Male; Middle Aged; Peripheral Nervous System Diseases; Prospective Studies; Retrospective Studies; Tryptophan; Tryptophan Oxygenase | 1998 |
Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid.
Topics: Animals; Brain; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice; Mixed Function Oxygenases; Prosencephalon; Quinolinic Acid; Spinal Cord; Tryptophan; Tryptophan Oxygenase | 1998 |
Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells.
Topics: Animals; Astrocytes; Cells, Cultured; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Quinolinic Acid; RNA, Messenger; Serotonin; Tryptophan | 1998 |
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells.
Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; Tryptophan; Tumor Cells, Cultured; Uveal Neoplasms | 1998 |
Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress.
Topics: Acute Disease; Circadian Rhythm; Female; Fetal Blood; Fetal Distress; Humans; Indoles; Infant, Newborn; Infant, Premature; Kynurenine; Male; Melatonin; Reference Values; Tryptophan; Umbilical Arteries; Umbilical Veins | 1998 |
Expression and regulation of interferon-gamma-induced tryptophan catabolism in cultured skin fibroblasts.
Topics: Calcimycin; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Induction; Fibroblasts; Gangliosides; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Protein Synthesis Inhibitors; Recombinant Proteins; Skin; Tryptophan; Tryptophan Oxygenase | 1998 |
Differential effects of kynurenine and tryptophan treatment on quinolinate immunoreactivity in rat lymphoid and non-lymphoid organs.
Topics: Animals; Immunohistochemistry; Injections, Intraperitoneal; Kynurenine; Lymphoid Tissue; Male; NAD; Organ Specificity; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 1998 |
Maternal, umbilical, and amniotic fluid concentrations of tryptophan and kynurenine after labor or cesarean section.
Topics: Adult; Amniotic Fluid; Cesarean Section; Female; Fetal Blood; Humans; Kynurenine; Pregnancy; Tryptophan | 1998 |
The analgesic effects of tryptophan and its metabolites in the rat.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates | 1998 |
Species differences in L-tryptophan-kynurenine pathway metabolism: quantification of anthranilic acid and its related enzymes.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Enzyme Activation; Gerbillinae; Guinea Pigs; Humans; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Injections, Intravenous; Kynurenine; Kynurenine 3-Monooxygenase; Macaca mulatta; Male; Mice; Mixed Function Oxygenases; ortho-Aminobenzoates; Rabbits; Rats; Species Specificity; Tryptophan; Tryptophan Oxygenase | 1998 |
Identification of tryptophan oxidation products in bovine alpha-crystallin.
Topics: 5-Hydroxytryptophan; Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Crystallins; Kynurenine; Mass Spectrometry; Methionine; Molecular Structure; Oxidation-Reduction; Peptide Fragments; Trypsin; Tryptophan | 1998 |
Activated immune system in patients with Huntington's disease.
Topics: Adult; Antigens, CD; Complement C3; Female; Humans; Huntington Disease; Immunoglobulins; Kynurenine; Male; Middle Aged; Neopterin; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tryptophan | 1998 |
Neuroactive tryptophan metabolites: focus on kynurenines.
Topics: Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenine; Nervous System; Tryptophan | 1998 |
Oxidative modification of glutamine synthetase by 2,2'-azobis(2- amidinopropane) dihydrochloride.
Topics: Amidines; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamate-Ammonia Ligase; Histidine; Kynurenine; Melitten; Methionine; Molecular Weight; Oxidants; Oxidation-Reduction; Reactive Oxygen Species; Time Factors; Tryptophan; Tyrosine | 1999 |
Oxidation of 3-hydroxykynurenine to produce xanthommatin for eye pigmentation: a major branch pathway of tryptophan catabolism during pupal development in the yellow fever mosquito, Aedes aegypti.
Topics: Aedes; Amino Acids; Animals; Eye Color; Hydrogen-Ion Concentration; Insect Proteins; Kynurenine; Monophenol Monooxygenase; Oxazines; Oxidation-Reduction; Pigments, Biological; Pupa; Reactive Oxygen Species; Tissue Distribution; Tryptophan; Xanthenes | 1999 |
Age-dependent changes in memory and mushroom bodies in the Drosophila mutant vermilion deficient in the kynurenine pathway of tryptophan metabolism.
Topics: Aging; Animals; Brain; Conditioning, Classical; Drosophila; Kynurenine; Memory; Mutation; Sexual Behavior, Animal; Tryptophan | 1999 |
Ommochrome deficiency in an albino strain of a terrestrial isopod, Armadillidium vulgare.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Crustacea; Female; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Oxazines; Phenothiazines; Phenotype; Pigmentation; Pigments, Biological; Sex Factors; Tryptophan; Tryptophan Oxygenase; Xanthenes | 1999 |
Growth inhibition of multiresistant enterococci by interferon-gamma-activated human uro-epithelial cells.
Topics: Blotting, Western; Cell Division; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enterococcus; Enzyme Induction; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; RNA, Messenger; Tryptophan; Tryptophan Oxygenase; Urothelium | 1999 |
Human placental indoleamine 2,3-dioxygenase: cellular localization and characterization of an enzyme preventing fetal rejection.
Topics: Ascorbic Acid; Binding, Competitive; Catalase; Cytoplasm; Enzyme Inhibitors; Female; Fetus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Isoenzymes; Kynurenine; Methylene Blue; Microvilli; Placenta; Subcellular Fractions; Substrate Specificity; Trophoblasts; Tryptophan; Tryptophan Oxygenase | 2000 |
UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside.
Topics: Acrylates; Adult; Aging; Benzoates; Chromatography, High Pressure Liquid; Deamination; Fetus; Glucosides; Humans; Hydrogen-Ion Concentration; Infant; Kynurenine; Lens, Crystalline; Middle Aged; Phenylbutyrates; Propionates; Tryptophan; Ultraviolet Rays | 1999 |
Tryptophan metabolism in pregnant sheep: increased fetal kynurenine production in response to maternal tryptophan loading.
Topics: Animals; Female; Fetal Blood; Fetus; Gestational Age; Hydrocortisone; Infusions, Intravenous; Kynurenine; Maternal-Fetal Exchange; Pregnancy; Pregnancy, Animal; Sheep; Tryptophan | 1999 |
TRH increases cerebrospinal fluid concentration of kynurenine.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electrodes; Epilepsy; Female; Humans; Infant; Kynurenine; Male; Receptors, N-Methyl-D-Aspartate; Spasms, Infantile; Thyrotropin-Releasing Hormone; Tryptophan; Tyrosine; Up-Regulation | 1999 |
Identification of modified tryptophan residues in apolipoprotein B-100 derived from copper ion-oxidized low-density lipoprotein.
Topics: Amino Acid Sequence; Apolipoprotein B-100; Apolipoproteins B; Chromatography, High Pressure Liquid; Copper; Humans; Kynurenine; Lipoproteins, LDL; Mass Spectrometry; Molecular Sequence Data; Oxidation-Reduction; Peroxidase; Phenylhydrazines; Spectrophotometry, Ultraviolet; Trypsin; Tryptophan | 1999 |
The Nitrite/alpha crystallin reaction: a possible mechanism in lens matrix damage.
Topics: Aging; Animals; Cataract; Cattle; Chromatography, High Pressure Liquid; Crystallins; Electrophoresis, Polyacrylamide Gel; Humans; Kynurenine; Lens, Crystalline; Nitrites; Oxidation-Reduction; Smoking; Spectrophotometry, Ultraviolet; Tryptophan; Ultraviolet Rays | 2000 |
Degradation of tryptophan in neurodegenerative disorders.
Topics: Alzheimer Disease; Biomarkers; Humans; Huntington Disease; Intellectual Disability; Interleukin-2; Kynurenine; Neopterin; Receptors, Interleukin-2; Receptors, Tumor Necrosis Factor; Tryptophan; Tumor Necrosis Factor-alpha | 1999 |
Effect of kynurenine on tryptophan-albumin binding in human plasma.
Topics: Humans; In Vitro Techniques; Kynurenine; Plasma; Serum Albumin; Tryptophan | 1999 |
Changes in membrane fluidity induced by tryptophan and its metabolites.
Topics: Animals; Cell Cycle; Cell Membrane; Cholesterol; Fatty Acids; Hydroxyindoleacetic Acid; Kinetics; Kynurenic Acid; Kynurenine; Liver; Male; Membrane Fluidity; Membrane Lipids; Phospholipids; Picolinic Acids; Rats; Rats, Wistar; Tryptophan; Xanthurenates | 1999 |
L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions.
Topics: 3-Hydroxyanthranilic Acid; Apoptosis; Humans; Kynurenine; Macrophages; Tryptophan; Tumor Cells, Cultured; U937 Cells | 1999 |
Degradation of tryptophan in patients with systemic lupus erythematosus.
Topics: Depression; Humans; Kynurenine; Lupus Erythematosus, Systemic; Neopterin; Reference Values; Tryptophan | 1999 |
Kynurenine and neopterin in chronic glomerulonephritis.
Topics: Biomarkers; Chronic Disease; Creatinine; Fasting; Glomerular Filtration Rate; Glomerulonephritis; Glomerulonephritis, Membranous; Humans; Immunity, Cellular; Kidney; Kidney Failure, Chronic; Kynurenine; Neopterin; Tryptophan | 1999 |
Involvement of tryptophan metabolism in the body color of crustacea.
Topics: 3-Hydroxyanthranilic Acid; Animals; Crustacea; Kynurenine; Mutation; Phenothiazines; Pigmentation; Pigments, Biological; Tryptophan | 1999 |
Kynurenine concentration of serum was increased by exercise.
Topics: Chromatography, High Pressure Liquid; Exercise; Heart Rate; Humans; Kynurenine; Male; Middle Aged; Soccer; Tryptophan | 1999 |
An HPLC method to determine tryptophan and kynurenine in serum simultaneously.
Topics: Calibration; Chromatography, High Pressure Liquid; Enzyme Induction; Humans; Interferon-gamma; Kynurenine; Tryptophan; Tryptophan Oxygenase | 1999 |
Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation.
Topics: CD40 Ligand; Cell Communication; Cells, Cultured; Chromatography, High Pressure Liquid; Coculture Techniques; Dendritic Cells; Drug Combinations; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Ligands; Lipopolysaccharides; Lymphocyte Activation; Membrane Glycoproteins; RNA, Messenger; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2000 |
Tryptophan degradation and immune activation in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Female; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Neopterin; Tryptophan | 2000 |
Serotonergic and kynurenic pathways in rats exposed to foot shock.
Topics: Animals; Brain; Brain Chemistry; Electroshock; Hydroxyindoleacetic Acid; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Rats; Rats, Wistar; Serotonin; Stress, Physiological; Tryptophan | 2000 |
Enhanced tryptophan degradation in systemic lupus erythematosus.
Topics: Adult; Aged; Female; Humans; Kynurenine; Lupus Erythematosus, Systemic; Male; Middle Aged; Neopterin; Tryptophan | 2000 |
Central nervous system activation of the indoleamine-2,3-dioxygenase pathway in human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
Topics: Adult; Aged; Brain; Enzyme Activation; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neopterin; Nitric Oxide; Paraparesis, Tropical Spastic; Tryptophan; Tryptophan Oxygenase | 2000 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Topics: 3-Hydroxyanthranilic Acid; Animals; Ascorbic Acid; Cataract; Cattle; Copper; Crystallins; Electrochemistry; Humans; Hydrogen Peroxide; Iron; Kynurenine; Lens, Crystalline; Metals; Oxidation-Reduction; Superoxides; Tryptophan | 2000 |
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Topics: Adult; Albuminuria; Animals; Carboxy-Lyases; Enzyme Inhibitors; Female; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Middle Aged; Mixed Function Oxygenases; Pentosyltransferases; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Tryptophan Oxygenase | 2000 |
Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices.
Topics: Aerobiosis; Animals; Brain; In Vitro Techniques; Kynurenine; Liver; Male; NAD; Organ Specificity; Oxygen; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2000 |
The kynurenine pathway of tryptophan degradation as a target for neuroprotective therapies.
Topics: Hydrolysis; Kynurenine; Neuroprotective Agents; Tryptophan | 2000 |
Evidence that kynurenine pathway metabolites mediate hyperbaric oxygen-induced convulsions.
Topics: Animals; Coma; Enzyme Inhibitors; Hyperbaric Oxygenation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; ortho-Aminobenzoates; Rats; Rats, Sprague-Dawley; Seizures; Sulfonamides; Thiazoles; Time Factors; Tryptophan | 2000 |
Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.
Topics: Age Factors; Animals; Courtship; Drosophila; Kynurenic Acid; Kynurenine; Learning; Male; Memory Disorders; Mutation; Neuroglia; Tryptophan | 2000 |
Kynurenic acid metabolism in the brain of HIV-1 infected patients.
Topics: Adult; AIDS Dementia Complex; Brain; Cerebellum; Female; Frontal Lobe; HIV-1; Humans; Kynurenic Acid; Kynurenine; Lyases; Male; Transaminases; Tryptophan | 2000 |
Effects of nicotine on head-shakes and tryptophan metabolites.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Head Movements; Hydroxyindoleacetic Acid; Indophenol; Kynurenine; Male; Mice; Nicotine; Nicotinic Agonists; Pyridines; Serotonin; Serotonin Receptor Agonists; Tics; Tryptophan | 2001 |
Neopterin production and tryptophan degradation in humans infected by Streptococcus pyogenes.
Topics: Humans; Kynurenine; Neopterin; Streptococcal Infections; Streptococcus pyogenes; Tonsillitis; Tryptophan | 2001 |
3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma.
Topics: 3-Hydroxyanthranilic Acid; Antioxidants; Apoptosis; Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Interferon-gamma; Kynurenine; Monocytes; Spectrophotometry; Tryptophan; Tumor Cells, Cultured; U937 Cells; Xanthine Oxidase | 2001 |
Human primary CD4 + T cells activated in the presence of IFN-alpha 2b express functional indoleamine 2,3-dioxygenase.
Topics: Base Sequence; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; DNA Primers; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon alpha-2; Interferon-alpha; Kynurenine; Lymphocyte Activation; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tryptophan; Tryptophan Oxygenase | 2001 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2001 |
Enzyme activities involved in tryptophan metabolism along the kynurenine pathway in rabbits.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Carboxy-Lyases; Dioxygenases; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestines; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mixed Function Oxygenases; Models, Chemical; Niacin; Oxygenases; Picolinic Acids; Rabbits; Tryptophan; Tryptophan Oxygenase | 2001 |
Some tryptophan pathways in the phytopathogen Xanthomonas oryzae pv. oryzae.
Topics: Catechols; Chromatography, High Pressure Liquid; Indoleacetic Acids; Kynurenine; ortho-Aminobenzoates; Plant Diseases; Tryptophan; Xanthomonas | 2000 |
Induction of indoleamine 2,3-dioxygenase in vivo by IFN-con1.
Topics: Enzyme Induction; Hepatitis C; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Type I; Interferon-alpha; Interferon-gamma; Kynurenine; Recombinant Proteins; Tryptophan; Tryptophan Oxygenase | 2001 |
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Topics: Cell Death; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Hydrolases; Interferon-gamma; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Macrophages; Mixed Function Oxygenases; Monocytes; Neurons; Neurotoxins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Tryptophan; Tumor Necrosis Factor-alpha | 2001 |
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan | 2001 |
L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
Topics: Animals; Antigens, Protozoan; Antigens, Surface; Brain; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protozoan Proteins; RNA, Messenger; Toxoplasma; Toxoplasmosis; Tryptophan; Tryptophan Oxygenase | 2002 |
Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.
Topics: Acute Disease; Animals; Disease Susceptibility; DNA-Binding Proteins; Gene Expression; Interferon Regulatory Factor-1; Interferon-gamma; Kinetics; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; RNA, Messenger; Toxoplasma; Toxoplasmosis; Tryptophan; Tryptophan Oxygenase | 2002 |
Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest.
Topics: Animals; Disease Models, Animal; Heart Arrest; Immune System; Kynurenine; Neopterin; Swine; Tryptophan; Tryptophan Oxygenase | 2001 |
More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Reproducibility of Results; Sensitivity and Specificity; Tryptophan | 2002 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates | 2002 |
Novel and sensitive high-performance liquid chromatographic method based on electrochemical coulometric array detection for simultaneous determination of catecholamines, kynurenine and indole derivatives of tryptophan.
Topics: Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Electrochemistry; Indoles; Kynurenine; Reproducibility of Results; Sensitivity and Specificity; Tryptophan | 2002 |
Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Carboxy-Lyases; Cholesterol, Dietary; Diabetes Mellitus, Experimental; Dioxygenases; Hyperlipidemias; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mixed Function Oxygenases; Niacin; Oxygenases; Rabbits; Tryptophan; Tryptophan Oxygenase | 2002 |
Cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-asociated cells: implications for persistent Chlamydophila pneumoniae infection.
Topics: Arteriosclerosis; CD4-Positive T-Lymphocytes; Cells, Cultured; Chlamydophila Infections; Chlamydophila pneumoniae; Endothelium, Vascular; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Muscle, Smooth, Vascular; Substrate Specificity; Tryptophan; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha | 2002 |
Increased neopterin production and tryptophan degradation in advanced Parkinson's disease.
Topics: Aged; Chromatography, High Pressure Liquid; Female; Humans; Immunity, Cellular; Kynurenine; Male; Neopterin; Parkinson Disease; Tryptophan | 2002 |
Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Colorectal Neoplasms; Humans; Interleukin-6; Kynurenine; Liver Neoplasms; Middle Aged; Quality of Life; Rectal Neoplasms; Regression Analysis; Survival Analysis; Tryptophan; Tumor Necrosis Factor-alpha | 2002 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates | 2001 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflammation; Injections, Subcutaneous; Kidney; Kynurenine; Lipopolysaccharides; Liver; Lung; Mass Spectrometry; Models, Biological; Protein Binding; Quinolinic Acid; Serum Albumin; Tissue Distribution; Tritium; Tryptophan | 2002 |
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis.
Topics: Animals; Axons; Cell Division; Cytokines; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Interleukin-4; Kinetics; Kynurenine; Lymph Nodes; Mice; RNA, Messenger; Spinal Cord; T-Lymphocytes; Treatment Outcome; Tryptophan; Tryptophan Oxygenase | 2002 |
Increased levels of 3-hydroxykynurenine in different brain regions of rats with chronic renal insufficiency.
Topics: Animals; Brain; Kidney Failure, Chronic; Kynurenine; Male; Rats; Rats, Wistar; Signal Transduction; Tryptophan; Uremia | 2002 |
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Cell Death; Cell Division; Cytotoxicity Tests, Immunologic; Dendritic Cells; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; T-Lymphocytes; Time Factors; Tryptophan; Tryptophan Oxygenase | 2002 |
Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.
Topics: Animals; Cell Division; Cells, Cultured; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Killer Cells, Natural; Kynurenine; Leukocytes, Mononuclear; Rabbits; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2002 |
Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV-1; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Tryptophan; Tryptophan Oxygenase | 2002 |
Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture.
Topics: Bacterial Proteins; Bacterial Toxins; Biological Transport, Active; Chlamydia muridarum; Chlamydia trachomatis; Chlamydiaceae; Chlamydophila pneumoniae; Chlamydophila psittaci; Escherichia coli Proteins; Evolution, Molecular; Gene Transfer, Horizontal; Genes, Bacterial; Genes, Regulator; Genetic Variation; Hydrolases; Kynurenine; Operon; Repressor Proteins; Ribose-Phosphate Pyrophosphokinase; Serine; Tryptophan | 2002 |
T cell apoptosis by tryptophan catabolism.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Autoimmune Diseases; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; fas Receptor; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Mitochondria; Quinolinic Acid; Self Tolerance; T-Lymphocytes; Th1 Cells; Thymus Gland; Tryptophan | 2002 |
CTLA-4-Ig regulates tryptophan catabolism in vivo.
Topics: Abatacept; Animals; Antigen Presentation; Antigens, CD; Antigens, Differentiation; B7-1 Antigen; Cells, Cultured; CTLA-4 Antigen; Dendritic Cells; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Graft Enhancement, Immunologic; Graft Survival; Imidazoles; Immune Tolerance; Immunoconjugates; Immunoglobulin G; Interferon-gamma; Islets of Langerhans Transplantation; Isoantigens; Kynurenine; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peptides; Pyridines; Recombinant Fusion Proteins; STAT1 Transcription Factor; Trans-Activators; Transplantation, Homologous; Tryptophan; Tryptophan Oxygenase | 2002 |
Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tryptophan | 2002 |
Longitudinal study of tryptophan degradation during and after pregnancy.
Topics: Adult; Alanine Transaminase; Antigens, CD; Biomarkers; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Kynurenine; Longitudinal Studies; Neopterin; Postpartum Period; Pregnancy; Pregnancy Trimesters; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tryptophan | 2003 |
Kynurenines and the respiratory parameters on rat heart mitochondria.
Topics: 3-Hydroxyanthranilic Acid; Animals; Free Radical Scavengers; In Vitro Techniques; Kinetics; Kynurenine; Male; Mitochondria, Heart; Mitochondrial Proteins; NAD; ortho-Aminobenzoates; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Succinates; Tryptophan | 2003 |
Tryptophan availability selectively limits NO-synthase induction in macrophages.
Topics: Animals; Arginine; Cell Line; Enzyme Induction; Interferon-gamma; Kynurenine; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Tryptophan; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha | 2003 |
[Separation and detection of tryptophan metabolites in biological samples].
Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Kynurenine; Serotonin; Trichloroacetic Acid; Tryptophan | 1999 |
Evidence for an altered tryptophan metabolism in fibromyalgia.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Fibromyalgia; Humans; Hydroxyindoleacetic Acid; Interleukin-6; Kynurenine; Middle Aged; Pain; Serotonin; Tryptophan | 2002 |
Immune activation and degradation of tryptophan in coronary heart disease.
Topics: Aged; Coronary Disease; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Tryptophan; Tryptophan Oxygenase | 2003 |
Anemia and congestive heart failure.
Topics: Anemia; Causality; Cell Division; Chronic Disease; Comorbidity; Dioxygenases; Heart Failure; Hematopoiesis; Hemoglobins; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Neopterin; Oxygenases; Prevalence; Tryptophan | 2003 |
Sustained-release niacin for prevention of migraine headache.
Topics: Delayed-Action Preparations; Female; Humans; Kynurenine; Middle Aged; Migraine Disorders; Niacin; Serotonin; Tryptophan; Vasodilator Agents | 2003 |
Immune cell proliferation is suppressed by the interferon-gamma-induced indoleamine 2,3-dioxygenase expression of fibroblasts populated in collagen gel (FPCG).
Topics: Animals; Cattle; Cell Division; Cell Movement; Cells, Cultured; Coculture Techniques; Collagen; Culture Media, Conditioned; Fibroblasts; Gels; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Tryptophan; Tryptophan Oxygenase | 2003 |
Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels.
Topics: Astrocytes; Astrocytoma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; NAD; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2003 |
Increased degradation of tryptophan in blood of patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomarkers; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Kynurenine; Male; Neopterin; Probability; Prognosis; Sensitivity and Specificity; Severity of Illness Index; Tryptophan | 2003 |
The excretion of kynurenine and 3-hydroxykynurenine by man.
Topics: Biological Transport; Humans; Kynurenine; Male; Tryptophan; Urine | 1954 |
[Observations on tryptophan metabolism in rats. II..].
Topics: Animals; Chromatography; Kynurenine; Rats; Tryptophan; Urine | 1954 |
Formation of formylkynurenine by the action of x-rays on tryptophan in aqueous solution.
Topics: Kynurenine; Tryptophan; X-Rays | 1954 |
Blocked kynurenine pathway of trytophan metabolism in hepatoma.
Topics: Carcinoma, Hepatocellular; Kynurenine; Liver Neoplasms; Liver Neoplasms, Experimental; Tryptophan | 1957 |
Studies on oxygenases; enzymatic formation of kynurenine from tryptophan.
Topics: Humans; Kynurenine; Oxidoreductases; Oxygenases; Tryptophan | 1957 |
The determination in urine of some metabolites of tryptophankynurenine, anthranilic acid and 3-hydroxyanthranilic acid- and reference to the presence of o-aminophenol in urine.
Topics: 3-Hydroxyanthranilic Acid; Aminobenzoates; Aminophenols; Humans; Kynurenine; ortho-Aminobenzoates; Phenols; Tryptophan | 1959 |
Enzyme activities of tryptophan metabolism along the kynurenine pathway in various species of animals.
Topics: Animals; Enzymes; Guinea Pigs; In Vitro Techniques; Intestine, Small; Kidney; Kynurenine; Liver; Male; Mice; Rabbits; Rats; Rats, Wistar; Species Specificity; Tryptophan | 2003 |
[Possibility of diagnosis of tumors of the bladder by chromatographic revelation of metabolites of the tryptophan-nicotinic acid interrelation].
Topics: Humans; Kynurenine; Niacin; ortho-Aminobenzoates; Tryptophan; Urinary Bladder Neoplasms; Urine | 1960 |
[Tryptophan loading and vitamin B6 deficiency. I. Excretion of xanthurenic acid, kynurenine, trigonelline amide, and 5-hydroxyindoleacetic acid in various diseases].
Topics: Alkaloids; Amides; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Niacin; Nicotinic Acids; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1961 |
Quantitative determination of tryptophan metabolites (via kynurenine) in biologic fluids.
Topics: Biological Products; Body Fluids; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 1959 |
The induction of tryptophan pyrrolase. I. Influence on the conversion of tryptophan to kynurenine and pyridine nucleotides in normal and carbon tetrachloride-treated rats.
Topics: Animals; Biochemical Phenomena; Carbon Tetrachloride; Kynurenine; Nucleosides; Nucleotides; Oxidoreductases; Pyridines; Rats; Tryptophan; Tryptophan Oxygenase | 1962 |
[Disorders of tryptophan metabolism in the pathogenic mechanism of hyperpyretic convulsions].
Topics: Child; Fever; Humans; Infant; Kynurenine; Seizures; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1962 |
[Metabolism of tryptophan in the newborn. Urinary excretion of kynurenine and its derivatives following 1-tryptophan loading].
Topics: Body Fluids; Humans; Infant; Infant, Newborn; Kynurenine; Tryptophan | 1961 |
A new pathway of D-tryptophan metabolism: enzymic formation of kynurenic acid via D-kynurenine.
Topics: Kynurenic Acid; Kynurenine; Tryptophan | 1961 |
Metabolism of tryptophan in cancer of various sites.
Topics: Indoleacetic Acids; Kynurenine; Neoplasms; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1963 |
Tryptophan-nicotinic acid metabolism in subjects recently or long since recovered from viral hepatitis.
Topics: Communicable Diseases; Hepatitis; Hepatitis A; Kynurenine; Niacin; Nicotinic Acids; Tryptophan | 1963 |
Genetic control of cytodifferentiation.
Topics: Alleles; Animals; Drosophila; Drosophila melanogaster; Gene Expression Regulation; Genetics; Kynurenine; Tryptophan | 1963 |
An inducible enzyme system in the larval cells of Drosophila melanogaster.
Topics: Animals; Drosophila; Drosophila melanogaster; Kynurenine; Larva; Oxidoreductases; Tryptophan | 1963 |
Urinary excretion of tryptophan metabolites in the healthy infant.
Topics: Chromatography; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Urine | 1962 |
[The loading test with L(-)tryptophan in viral hepatitis].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Clinical Enzyme Tests; D-Alanine Transaminase; Fructose-Bisphosphate Aldolase; Hepatitis; Hepatitis A; Humans; Kynurenine; Pyridoxine; Tryptophan | 1962 |
[Investigations of tryptophane degradation and vitamin B-6 metabolism in the newborn and in the young infant].
Topics: Biochemical Phenomena; Humans; Infant; Infant, Newborn; Infant, Premature; Kynurenine; Pyridoxine; Tryptophan; Vitamins | 1963 |
Quantitative studies on tryptophan metabolism in the pyridoxine-deficient rat.
Topics: Animals; Kynurenine; Pyridoxine; Rats; Tryptophan; Vitamin B 6 Deficiency | 1963 |
[PRELIMINARY INFORMATION ON THE MECHANISM OF PSYCHOTROPIC ACTION OF CYCLOSERINE ISOMERS].
Topics: Central Nervous System; Cycloserine; Electroencephalography; Humans; Indoleacetic Acids; Kynurenine; Tryptophan; Urine | 1963 |
PRELIMINARY STUDIES ON TRYPTOPHAN PYRROLASE ACTIVITY IN MICE.
Topics: Adenocarcinoma; Animals; Kynurenine; Liver; Mice; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Peroxidases; Research; Sex; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1963 |
ABSENCE OF KYNURENINE IN CULTURES OF MICROSPORUM CANIS GROWN IN TRYPTOPHANE ENRICHED SABOURAUD'S AGAR.
Topics: Agar; Chromatography; Fluorescence; Kynurenine; Microscopy; Microscopy, Fluorescence; Microsporum; Tryptophan | 1963 |
THE METABOLISM OF TRYPTOPHAN IN PATIENTS WITH BLADDER CANCER AND OTHER UROLOGICAL DISEASES.
Topics: Geriatrics; Humans; Kidney Neoplasms; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prostatic Neoplasms; Proteins; Tryptophan; Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urine | 1963 |
[CHANGES IN TRYPTOPHAN METABOLISM IN THE WINKING-NODDING SPASM IN INFANTS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blinking; Blood Chemical Analysis; Chromatography; Electroencephalography; Hippurates; Humans; Infant; Kynurenic Acid; Kynurenine; Metabolism; Proteins; Pyridoxine; Research; Spasm; Spasms, Infantile; Tryptophan; Urine; Xanthurenates | 1963 |
STUDIES ON MORPHINE. III. ACTION OF METABOLIC PRECURSORS TO SEROTONIN AND NORADRENALINE AND RELATED SUBSTANCES ON THE "ABSTINENCE SYNDROME" TO MORPHINE ON WHITE MICE.
Topics: Brain; Catecholamines; Dihydroxyphenylalanine; Ergot Alkaloids; Iproniazid; Kynurenine; Lysergic Acid Diethylamide; Methyldopa; Mice; Morphine; Nalorphine; Norepinephrine; ortho-Aminobenzoates; Pharmacology; Phenylalanine; Research; Serotonin; Shikimic Acid; Toxicology; Tryptophan; Tyrosine | 1963 |
THE DETECTION OF SOME INDOLES AND RELATED COMPOUNDS ON PAPER CHROMATOGRAMS.
Topics: 4-Aminobenzoic Acid; Amino Acids; Chromatography; Citrulline; Indicators and Reagents; Indoleacetic Acids; Indoles; Kynurenine; ortho-Aminobenzoates; Phenols; Quinolines; Research; Thiourea; Tryptophan; Urea; Xanthurenates | 1964 |
OCCURRENCE OF C14-OXALATE IN RAT URINE AFTER ADMINISTRATION OF C14-TRYPTOPHAN.
Topics: Body Fluids; Carbon Isotopes; Kynurenine; Metabolism; Oxalates; Pharmacology; Rats; Research; Tryptophan; Urine; Vitamin B 6 Deficiency | 1963 |
THE EXCRETION OF TRYPTOPHAN METABOLITES FOLLOWING DEOXYPYRIDOXINE ADMINISTRATION IN MONGOLOID AND NONMONGOLOID PATIENTS.
Topics: Child; Down Syndrome; Humans; Kynurenine; Metabolism; Tryptophan; Urine; Vitamin B 6 Deficiency; Xanthurenates | 1964 |
TRYPTOPHAN METABOLISM IN SPECIAL PAIRS OF TWINS.
Topics: Chromatography; Diseases in Twins; Genetics, Medical; Kynurenic Acid; Kynurenine; Metabolic Diseases; ortho-Aminobenzoates; Proteins; Schizophrenia; Spectrophotometry; Tryptophan; Urine; Xanthurenates | 1964 |
EXCRETION OF TRYPTOPHAN METABOLITES IN DIFFERENT FORMS OF HAEMOBLASTOSIS.
Topics: Cortisone; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Kynurenic Acid; Kynurenine; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Multiple Myeloma; ortho-Aminobenzoates; Phenylbutazone; Polycythemia Vera; Proteins; Pyridoxal Phosphate; Pyridoxine; Sarcoma; Severe Combined Immunodeficiency; Tryptophan; Urine; Xanthurenates | 1964 |
STUDIES ON THE TRYPTOPHAN METABOLISM IN TUMOR-BEARING ANIMALS.
Topics: Animals; Kynurenic Acid; Kynurenine; Liver; Neoplasms; Neoplasms, Experimental; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Proteins; Rats; Research; Sarcoma; Tryptophan; Urine; Xanthurenates | 1964 |
BIOCHEMICAL ASPECTS OF THE HARTNUP DISEASE. II. SOME OBSERVATIONS ON RATS ABOUT TRYPTOPHAN METABOLISM.
Topics: Child; Clinical Enzyme Tests; Hartnup Disease; Humans; Indican; Indoles; Kidney; Kynurenine; Metabolic Diseases; Neomycin; Niacin; Niacinamide; Nicotinic Acids; Nystatin; Pellagra; Rats; Renal Aminoacidurias; Tryptophan; Urine | 1964 |
EFFECT OF P-CHLOROMERCURIBENZOATE ON TRYPTOPHAN PEROXIDASE OF NORMAL RAT LIVER IN VITRO.
Topics: Benzoates; Chloromercuribenzoates; Cysteine; In Vitro Techniques; Kynurenine; Liver; Mercury; Oxidoreductases; Peroxidase; Peroxidases; Pharmacology; Rats; Research; Spectrophotometry; Tryptophan | 1964 |
[METABOLIC STUDIES IN A GROUP OF CHILDREN WITH MENTAL DEFICIENCY: URINARY ELIMINATION OF AMINO ACIDS, CARBOHYDRATES, TRYPTOPHAN METABOLITES AND ABNORMAL METABOLITES].
Topics: Amino Acids; Body Fluids; Carbohydrates; Child; Galactose; Glycosaminoglycans; Humans; Imidazoles; Infant; Intellectual Disability; Kynurenine; Metabolism; Tryptophan; Urine; Xanthurenates | 1964 |
MUTANT GENES REGULATING THE INDUCIBILITY OF KYNURENINE SYNTHESIS.
Topics: Alleles; Animals; Chromosomes; Drosophila; Drosophila melanogaster; Genotype; Kynurenine; Luminescence; Mutation; Research; Tryptophan | 1964 |
FACTORS AFFECTING THE INTRACELLULAR SYNTHESIS OF KYNURENINE.
Topics: Animals; Drosophila; Drosophila melanogaster; Fluorescence; Kynurenine; Larva; Proteins; Pterins; Research; Tryptophan | 1964 |
A METHOD FOR THE DETERMINATION OF EIGHT TRYPTOPHAN METABOLITES IN BIOLOGICAL FLUIDS.
Topics: Blood Proteins; Cerebrospinal Fluid Proteins; Chromatography; Humans; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Spectrophotometry; Tryptophan; Urine; Xanthurenates | 1964 |
TRYPTOPHAN-NICOTINIC ACID METABOLISM IN CHRONIC ALCOHOLICS.
Topics: Alcoholics; Alcoholism; Humans; Kynurenine; Liver Cirrhosis; Metabolism; Niacin; Nicotinic Acids; Tryptophan; Urine; Xanthurenates | 1964 |
DETERMINATION OF FREE AND TOTAL INDOLE-3-ACETIC ACID AND OF THE INDOLE INDEX.
Topics: Friedreich Ataxia; Humans; Indoleacetic Acids; Indoles; Intestines; Kynurenine; Metabolism; Myotonia; Phenylketonurias; Poisoning; Research; Schizophrenia; Tryptophan; Urine | 1964 |
METABOLISM OF 3-HYDROXYANTHRANILIC ACID-CARBOXYL-C14 IN THE HUMAN.
Topics: 3-Hydroxyanthranilic Acid; Achondroplasia; Blood; Carbon Isotopes; Chromatography; Hippurates; Humans; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Rats; Research; Tryptophan; Urine; Xanthurenates | 1964 |
URINARY EXCRETION OF TRYPTOPHAN METABOLITES IN PATIENTS WITH RENAL PELVIS AND PARENCHYMA TUMOURS.
Topics: Chromatography; Humans; Kidney Neoplasms; Kidney Pelvis; Kynurenic Acid; Kynurenine; Neoplasms; ortho-Aminobenzoates; Spectrophotometry; Tryptophan; Urine; Xanthurenates | 1964 |
EXCRETION OF TRYPTOPHAN METABOLITES BY PATIENTS WITH RHEUMATOID ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Biomedical Research; Chromatography; Gout; Hippurates; Indoles; Kynurenic Acid; Kynurenine; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Proteins; Psoriasis; Pyridines; Pyridoxine; Spondylitis; Tryptophan; Urine; Xanthurenates | 1964 |
HYDROXYKYNURENINURIA: A CASE OF ABNORMAL TRYPTOPHAN METABOLISM PROBABLY DUE TO A DEFICIENCY OF KYNURENINASE.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Chromatography; Electrophoresis; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Metabolic Diseases; Niacin; ortho-Aminobenzoates; Proteins; Pyridoxine; Spectrophotometry; Tryptophan; Urine; Xanthurenates | 1964 |
ABNORMAL TRYPTOPHAN METABOLISM IN PATIENTS WITH ADULT CELIAC DISEASE, WITH EVIDENCE FOR DEFICIENCY OF VITAMIN B6.
Topics: Adult; Biochemical Phenomena; Biochemistry; Celiac Disease; Dietary Proteins; Glutens; Humans; Hydroxyindoleacetic Acid; Indican; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Proteins; Tetracycline; Tryptophan; Urine; Vitamin B 6; Vitamin B 6 Deficiency; Xanthurenates | 1964 |
HG2+ EFFECT ON TRYPTOPHAN PEROXIDASE (PYRROLASE) AT THE SUB-CELLULAR LEVEL.
Topics: Chloromercuribenzoates; Coloring Agents; Cysteine; Dialysis; Kynurenine; Liver; Mercury; Peroxidase; Peroxidases; Pharmacology; Rats; Renal Dialysis; Research; Spectrophotometry; Sulfhydryl Compounds; Tryptophan | 1964 |
REGULATORY MECHANISMS GOVERNING SYNTHESIS OF THE ENZYMES FOR TRYPTOPHAN OXIDATION BY PSEUDOMONAS FLUORESCENS.
Topics: Amidohydrolases; Catechols; Enzymes; Hydrolases; Kynurenine; Lactones; ortho-Aminobenzoates; Proteins; Pseudomonas; Pseudomonas fluorescens; Pyrroles; Tryptophan | 1964 |
IN VIVO ELUTION OF TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS FROM CHOLESTEROL PELLETS IMPLANTED INTO MOUSE BLADDERS.
Topics: Amines; Animals; Carcinogens; Cholesterol; Fluorenes; Hydroxylamines; Kynurenic Acid; Kynurenine; Metabolism; Mice; Naphthalenes; Nitrogen; Nitrogen Compounds; ortho-Aminobenzoates; Pharmacology; Quinolines; Research; Stearic Acids; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xanthurenates | 1964 |
MOUSE BLADDER CARCINOGENICITY OF CERTAIN TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS SUSPENDED IN CHOLESTEROL.
Topics: Amines; Animals; Carcinogens; Cholesterol; Fluorenes; Hydroxylamines; Kynurenic Acid; Kynurenine; Metabolism; Mice; Naphthalenes; Neoplasms; Neoplasms, Experimental; Nitrogen; Nitrogen Compounds; ortho-Aminobenzoates; Pharmacology; Quinolines; Research; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1964 |
TRYPTOPHAN ANALOGUES AND THE MECHANISM OF INDUCTION OF RAT-LIVER TRYPTOPHAN PYRROLASE, IN VIVO.
Topics: Adrenalectomy; Cortisone; Kynurenine; Liver; Peroxidases; Pharmacology; Rats; Research; Tryptophan; Tryptophan Oxygenase | 1964 |
INDUCTION OF HEME-PROTEIN ENZYME IN ANIMAL. II. INCREASED TURNOVER RATES OF RIBONUCLEIC ACID, PROTEIN AND HEME CAUSED BY THE SUBSTRATE ADMINISTRATION.
Topics: Amides; Amino Acids; Carbon Isotopes; Glycine; Heme; Hemeproteins; Hypnotics and Sedatives; Kynurenine; Liver; Peroxidases; Pharmacology; Phosphorus Isotopes; Proteins; Rats; Research; RNA; Tryptophan | 1964 |
THE METABOLISM OF ALPHA-N-MONOMETHYL-L-TRYPTOPHAN (L-ABRIN) IN MAN AND IN NORMAL AND PYRIDOXINE DEFICIENT RATS.
Topics: Abrin; Amino Acids; Body Fluids; Eclampsia; Female; Humans; Kynurenine; Male; Niacin; Niacinamide; Pregnancy; Pyridoxine; Rats; Research; Tryptophan; Urine; Vitamin B 6 Deficiency; Xanthurenates | 1964 |
VITAMIN B6 REQUIREMENT FOR ADULT MEN.
Topics: Adult; Ascorbic Acid; Blood; Diet; Dietary Proteins; Humans; Kynurenine; Male; Oxalates; Pyridoxine; Tryptophan; Urine; Vitamin B 6; Vitamin B 6 Deficiency; Xanthurenates | 1964 |
TRYPTOPHAN METABOLISM IN MAN.
Topics: Amino Acid Metabolism, Inborn Errors; Calcium; Child; Glucuronates; Humans; Indican; Indoleacetic Acids; Intestinal Absorption; Kynurenine; Male; Metabolism; ortho-Aminobenzoates; p-Aminohippuric Acid; Pyridines; Tryptophan; Urine; Xanthurenates | 1964 |
STUDIES ON THE URINARY EXCRETION OF CERTAIN TRYPTOPHAN METABOLITES BEFORE AND AFTER TRYPTOPHAN LOADING DOSE IN BILHARZIASIS, BILHARZIAL BLADDER CANCER AND CERTAIN OTHER TYPES OF MALIGNANCIES IN EGYPT.
Topics: Amino Acids; Egypt; Epidemiology; Fluids and Secretions; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenic Acid; Kynurenine; Neoplasms; ortho-Aminobenzoates; Schistosomiasis; Tryptophan; Urinary Bladder Neoplasms; Urine; Xanthurenates | 1964 |
LIVER TRYPTOPHAN PYRROLASE ACTIVITY IN FED AND STARVED FEMALE RABBITS.
Topics: Animals; Female; Kynurenine; Lagomorpha; Liver; Metabolism; Oxidation-Reduction; Peroxidases; Rabbits; Research; Starvation; Tryptophan; Tryptophan Oxygenase | 1964 |
VITAMIN B6 DEPLETION IN MAN: URINARY EXCRETION OF TRYPTOPHAN METABOLITES.
Topics: Amino Acids; Avitaminosis; Humans; Kynurenine; Sulfates; Tryptophan; Urine; Vitamin B 6; Vitamin B 6 Deficiency; Xanthurenates | 1964 |
TRYPTOPHAN MODIFICATION IN POLYPEPTIDE CHAINS.
Topics: Chemical Phenomena; Chemistry; Cystine; Kynurenine; Methionine; Oxidation-Reduction; Ozone; Peptides; Research; Resorcinols; Tryptophan; Tyrosine | 1964 |
TRYPTOPHAN METABOLISM IN RHEUMATIC DISEASE.
Topics: Amino Acids; Arthritis; Arthritis, Rheumatoid; Chromatography; Humans; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; ortho-Aminobenzoates; Rheumatic Diseases; Scleroderma, Systemic; Tryptophan; Urine; Xanthurenates | 1964 |
TRYPTOPHAN METABOLITE EXCRETION IN CONNECTIVE TISSUE DISEASES DEMONSTRATING A DIFFERENCE BETWEEN RHEUMATOID SPONDYLITIS AND RHEUMATOID ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Connective Tissue Diseases; Diagnosis, Differential; Humans; Kynurenine; Lupus Erythematosus, Systemic; Metabolism; Scleroderma, Systemic; Spondylitis; Spondylitis, Ankylosing; Tryptophan; Urine | 1964 |
FORMATION OF TRYPTOPHAN-PYRROLASE IN LEUKAEMIC CELLS INCUBATED WITH RNA OBTAINED FROM THE SPLEEN OF CALF EMBRYO.
Topics: Animals; Cattle; DNA; Kynurenine; Leukemia; Leukemia, Myeloid; Metabolism; Oxygenases; Pharmacology; Research; RNA; Spleen; Tissue Culture Techniques; Tryptophan; Tryptophan Oxygenase; Uridine | 1964 |
REGULATION OF MAMMALIAN TRYPTOPHAN PYRROLASE ACTIVITY DURING DEVELOPMENT.
Topics: Amino Acids; Animals; Animals, Newborn; Copper; Edetic Acid; Growth; Kynurenine; Liver; Mammals; Oxidation-Reduction; Oxygenases; Pharmacology; Rats; Research; Tryptophan; Tryptophan Oxygenase | 1964 |
[RESEARCH ON THE TRYPTOPHAN--NICOTINIC ACID PATHWAY IN DIABETES MELLITUS].
Topics: Diabetes Mellitus; Geriatrics; Hippurates; Insulin; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; Research; Tryptophan; Urine | 1964 |
DISORDERS OF TRYPTOPHAN METABOLISM IN LEUKAEMIA.
Topics: Amino Acids; Child; Humans; Indoles; Kynurenine; Leukemia; ortho-Aminobenzoates; Tryptophan | 1964 |
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Benzene; Carbon Dioxide; Carbon Isotopes; Cats; Chromatography; Coenzyme A; Electrophoresis; Glutarates; Keto Acids; Kynurenine; Liver; Metabolism; NAD; ortho-Aminobenzoates; Pseudomonas; Pyridines; Research; Tryptophan | 1965 |
[RESEARCH ON ELIMINATION OF METABOLITES OF THE TRYPTOPHAN TO NICOTINIC ACID PATHWAY IN INFANTS].
Topics: Chromatography; Diet; Hippurates; Humans; Infant; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Urine; Vitamins; Xanthurenates | 1964 |
[CONTRIBUTION TO THE STUDY OF METABOLITES OF THE TRYPTOPHAN TO NICOTINIC ACID PATHWAY IN RELATION TO SEX].
Topics: Humans; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; Research; Sex; Tryptophan; Urine; Xanthurenates | 1964 |
STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS.
Topics: Animals; Carbon Isotopes; Cats; Diabetes Mellitus, Experimental; Glutarates; Kidney; Kynurenine; Ligases; Liver; Mammals; Metabolism; NAD; Nucleotides; Phosphotransferases; Radiometry; Rats; Research; Transferases; Tryptophan | 1965 |
TRYPTOPHAN METABOLISM IN PSYCHOTIC CHILDREN. A PRELIMINARY REPORT.
Topics: Amino Acids; Child; Humans; Hydrolases; Kynurenine; Mental Disorders; Psychotic Disorders; Pyridoxine; Tryptophan | 1965 |
INVESTIGATIONS ON THE TRYPTOPHANE METABOLISM (VIA KYNURENINE) IN SCHIZOPHRENIC PATIENTS.
Topics: Amino Acids; Humans; Kynurenine; Schizophrenia; Tryptophan; Urine; Xanthurenates | 1964 |
STUDIES ON THE ROLE OF HEMATIN IN THE CATALYTIC MECHANISM OF TRYPTOPHAN PYRROLASE.
Topics: Catalysis; Coenzymes; Heme; Hemin; Kynurenine; Peroxidases; Porphyrins; Pseudomonas; Research; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1965 |
EFFECTS OF PEROXIDE, CATALASE, AND HEMATIN IN THE ASSAY OF LIVER TRYPTOPHAN PYRROLASE.
Topics: Animals; Biochemical Phenomena; Biochemistry; Biological Assay; Catalase; Heme; Hemin; Hydrogen Peroxide; Kynurenine; Liver; Mice; Oxygenases; Peroxides; Pharmacology; Rats; Research; Spectrophotometry; Tryptophan; Tryptophan Oxygenase | 1965 |
4-METHYL-3-HYDROXYANTHRANILIC ACID, AN INTERMEDIATE IN ACTINOMYCIN BIOSYNTHESIS.
Topics: Amino Acids; Chromatography; Dactinomycin; Kynurenine; Metabolism; ortho-Aminobenzoates; Pharmacology; Research; Streptomyces; Tryptophan; Valine | 1965 |
SEPARATION AND ESTIMATION OF TRYPTOPHAN-NICOTINIC ACID METABOLITES IN URINE BY THIN-LAYER CHROMATOGRAPHY.
Topics: Azo Compounds; Chromatography; Chromatography, Thin Layer; Colorimetry; Humans; Indicators and Reagents; Kynurenine; Niacin; Nicotinic Acids; ortho-Aminobenzoates; Tryptophan; Urine; Xanthurenates | 1965 |
[ELIMINATION OF METABOLITES OF TRYPTOPHAN IN THE PYRIDOXINE-DEFICIENT RAT AFTER DIFFERENT DOSES OF TRYPTOPHAN AND IN DIVERSE URINARY FRACTIONS].
Topics: Body Fluids; Hippurates; Kynurenine; Metabolism; Niacin; Niacinamide; Pyridoxine; Rats; Research; Tryptophan; Urinary Tract; Urine; Vitamin B 6 Deficiency; Xanthurenates | 1965 |
[Zinc binding capacity and glycemic effect of xanthurenic acid kynurenine and tryptophan].
Topics: Blood Glucose; Humans; Kynurenine; Transcription, Genetic; Tryptophan; Xanthurenates; Zinc | 1954 |
Neurotoxic and neurobehavioral effects of kynurenines in adult insects.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Survival; Cells, Cultured; Diptera; Dose-Response Relationship, Drug; Grasshoppers; Insecta; Kynurenine; Lethal Dose 50; Nervous System; Neurons; Neurotoxicity Syndromes; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2003 |
lambda-Hydroxytryptophan, not an intermediate between tryptophan and kynurenine.
Topics: 5-Hydroxytryptophan; Humans; Kynurenine; Tryptophan | 1950 |
The conversion of tryptophan to kynurenine in liver. I. The coupled tryptophan peroxidase-oxidase system forming formylkynurenine.
Topics: Coloring Agents; Humans; Kynurenine; Liver; Oxidoreductases; Peroxidase; Peroxidases; Tryptophan | 1950 |
The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine.
Topics: Humans; Hydrolysis; Kynurenine; Liver; Tryptophan | 1950 |
[Transformation of kynurenin into nicotinic acid in the rat and in Neurospora crassa].
Topics: Animals; Kynurenine; Neurospora crassa; Niacin; Nicotinic Acids; Rats; Tryptophan | 1950 |
[Paper chromatography of the biologic decomposition of kynurenin and related substances].
Topics: Biological Products; Chromatography, Paper; Humans; Kynurenine; Tryptophan | 1951 |
[First data on the elimination of kynurenine in man after administration of tryptophan].
Topics: Biological Transport; Humans; Kynurenine; Male; Tryptophan | 1951 |
[Paper chromatographic separation of tryptophane, alpha-oxy-tryptophane, kynurenine and 3-oxy-kynurenine].
Topics: Chromatography, Paper; Humans; Kynurenine; Tryptophan | 1951 |
[On the colorimetric determination of kynurenine and other derivatives of tryptophan].
Topics: Colorimetry; Humans; Kynurenine; Tryptophan | 1951 |
[Chromatography on hydrocellulose powder; application to the quantitative separation of tryptophan and kynurenin].
Topics: Chromatography; Kynurenine; Powders; Tryptophan | 1951 |
[Kynurenin, precursor of ortho-aminoacetophenone in the decomposition of tryptophan under the influence of diluted alkalies].
Topics: Acetophenones; Alkalies; Humans; Kynurenine; Tryptophan | 1951 |
The metabolism of d- and l-tryptophan and d- and l-kynurenine by liver and kidney preparations.
Topics: Kidney; Kynurenine; Liver; Tryptophan | 1952 |
Cell surface expression of MHC class I antigen is suppressed in indoleamine 2,3-dioxygenase genetically modified keratinocytes: implications in allogeneic skin substitute engraftment.
Topics: Blotting, Western; Cells, Cultured; Dioxygenases; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Histocompatibility Antigens Class I; HLA-A Antigens; HLA-B Antigens; HLA-C Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Keratinocytes; Kynurenine; Microscopy, Fluorescence; Reverse Transcriptase Polymerase Chain Reaction; Skin Transplantation; Transfection; Transplantation, Homologous; Tryptophan | 2004 |
Interference of some tryptophan metabolites in the formation of melanin in vitro.
Topics: 3-Hydroxyanthranilic Acid; Agaricales; Catalysis; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; In Vitro Techniques; Kynurenine; Magnetic Resonance Spectroscopy; Melanins; Models, Chemical; Monophenol Monooxygenase; Oxygen; Pigmentation; Spectrophotometry; Time Factors; Tryptophan; Tyrosine; Ultraviolet Rays | 2004 |
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.
Topics: Cloning, Molecular; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Genes, Bacterial; Iron; Iron Chelating Agents; Kynurenine; Molecular Sequence Data; Mutagenesis, Insertional; Pseudomonas fluorescens; Quinolines; Siderophores; Tryptophan; Xanthurenates | 2004 |
PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro.
Topics: Cells, Cultured; Concanavalin A; Ethanol; Humans; Interferon-gamma; Iron Chelating Agents; Kynurenine; Mitogens; Monocytes; Neopterin; Phytohemagglutinins; Plant Extracts; Solvents; Tryptophan | 2004 |
Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha.
Topics: Adult; Aged; Antineoplastic Agents; Female; Folic Acid; Homocysteine; Humans; Interferon alpha-2; Interferon-alpha; Kynurenine; Macrophage Activation; Male; Melanoma; Middle Aged; Neopterin; Predictive Value of Tests; Recombinant Proteins; Tryptophan; Vitamin B 12 | 2004 |
Down-regulatory effect of N-chlorotaurine on tryptophan degradation and neopterin production in human PBMC.
Topics: Cell Survival; Concanavalin A; Down-Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Neopterin; Phytohemagglutinins; Taurine; Tryptophan; Tryptophan Oxygenase | 2004 |
[Metabolic disturbance of tryptophan-nicotinamide conversion pathway by putative endocrine disruptors, bisphenol A and styrene monomer].
Topics: Animals; Benzhydryl Compounds; Body Weight; Eating; Hydrolases; Kynurenine; Liver; Male; Niacinamide; Phenols; Rats; Styrene; Tryptophan | 2004 |
Tryptophan degradation during and after gestation.
Topics: Adult; Alanine Transaminase; Antigens, CD; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Longitudinal Studies; Neopterin; Postpartum Period; Pregnancy; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tryptophan; Tryptophan Oxygenase | 2003 |
The mechanism of interferon-gamma induced anti Toxoplasma gondii by indoleamine 2,3-dioxygenase and/or inducible nitric oxide synthase vary among tissues.
Topics: Animals; Brain; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Tissue Distribution; Toxoplasma; Toxoplasmosis, Animal; Toxoplasmosis, Cerebral; Tryptophan; Tryptophan Oxygenase | 2003 |
Kynurenine metabolism in central nervous system in experimental chronic renal failure.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Kidney Failure, Chronic; Kynurenine; Male; ortho-Aminobenzoates; Rats; Rats, Wistar; Tissue Distribution; Tryptophan | 2003 |
T cell apoptosis by kynurenines.
Topics: Animals; Apoptosis; Caspase Inhibitors; Cysteine Proteinase Inhibitors; In Vitro Techniques; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Self Tolerance; T-Lymphocytes; Tryptophan | 2003 |
Experimental evaluation of an altered tryptophan metabolism in fibromyalgia.
Topics: Adult; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Female; Fibromyalgia; Humans; Hydroxyindoleacetic Acid; Interleukin-6; Kynurenine; Middle Aged; Pain; Serotonin; Tryptophan | 2003 |
Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Etidronic Acid; Female; Humans; Kynurenine; Methotrexate; Neopterin; Osteoporosis; Prednisolone; Raloxifene Hydrochloride; Receptors, Glutamate; Tryptophan | 2003 |
Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts.
Topics: Biomarkers; Case-Control Studies; Coronary Disease; Homocysteine; Humans; Kynurenine; Neopterin; Prognosis; Pyridoxal Phosphate; Tryptophan | 2003 |
Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection.
Topics: Adult; Anti-HIV Agents; Case-Control Studies; Female; HIV Infections; HIV-1; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Male; Middle Aged; Neopterin; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan and quality of life in colorectal cancer.
Topics: Case-Control Studies; Colorectal Neoplasms; Humans; Kynurenine; Quality of Life; Th1 Cells; Tryptophan | 2003 |
Effects of chronic lung inflammation on tryptophan metabolism in piglets.
Topics: Animals; Chronic Disease; Freund's Adjuvant; Kynurenine; Pneumonia; Sus scrofa; Swine Diseases; Tryptophan | 2003 |
Kynurenine and neopterin in the aqueous humor of the anterior chamber of the eye and in serum of cataract patients.
Topics: Aged; Aged, 80 and over; Aqueous Humor; Cataract; Exfoliation Syndrome; Humans; Kynurenine; Neopterin; Oxidative Stress; Selenium; Tryptophan | 2003 |
The kynurenine pathway enzymes in healthy and hyperlipidemic rabbits.
Topics: Animals; Hyperlipidemias; Intestine, Small; Kidney; Kynurenine; Liver; Male; Rabbits; Tryptophan; Tryptophan Oxygenase | 2003 |
Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits.
Topics: Animals; Cholesterol, Dietary; Diabetes Mellitus, Experimental; Intestine, Small; Kidney; Kynurenine; Liver; Rabbits; Tryptophan; Tryptophan Oxygenase | 2003 |
Kidney and liver kynurenine pathway enzymes in chronic renal failure.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Failure, Chronic; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Wistar; Tryptophan; Tryptophan Oxygenase | 2003 |
Kynurenine pathway enzymes in different species of animals.
Topics: Animals; Guinea Pigs; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestine, Small; Kidney; Kynurenine; Liver; Male; Mice; Rabbits; Rats; Rats, Wistar; Species Specificity; Superoxide Dismutase; Tryptophan; Tryptophan Oxygenase | 2003 |
Kynurenine pathway enzymes in guinea pigs.
Topics: Animals; Female; Guinea Pigs; Intestine, Small; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Mixed Function Oxygenases; Superoxide Dismutase; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan metabolism in rabbits.
Topics: Animals; Apoenzymes; Holoenzymes; Intestine, Small; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mixed Function Oxygenases; Rabbits; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan metabolism along the kynurenine pathway in rats.
Topics: Animals; Intestine, Small; Kidney; Kynurenine; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase; Tryptophan; Tryptophan Oxygenase | 2003 |
Enzyme activities along the kynurenine pathway in mice.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Dioxygenases; Intestine, Small; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Mixed Function Oxygenases; Oxygenases; Superoxide Dismutase; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan metabolism was accelerated by exercise in rat.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Macrophages; Male; Physical Exertion; Rats; Rats, Wistar; Tryptophan; Tryptophan Oxygenase | 2003 |
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase.
Topics: Animals; Brain; Enzyme Inhibitors; Gerbillinae; Humans; In Vitro Techniques; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Models, Molecular; Neuroprotective Agents; Protein Conformation; Tryptophan | 2003 |
Double mechanism for apical tryptophan depletion in polarized human bronchial epithelium.
Topics: Amino Acid Transport Systems; Biological Transport; Bronchi; Cell Polarity; Cells, Cultured; Cystic Fibrosis Transmembrane Conductance Regulator; Dioxygenases; Epithelial Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Membrane Potentials; Oxygenases; RNA, Messenger; Sodium; Tryptophan | 2004 |
An investigation on the role of 3-hydroxykynurenine in pigment formation by matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Agaricales; Kynurenine; Molecular Structure; Monophenol Monooxygenase; Pigments, Biological; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tryptophan | 2004 |
Temperature-sensitive polymer-conjugated IFN-gamma induces the expression of IDO mRNA and activity by fibroblasts populated in collagen gel (FPCG).
Topics: Antineoplastic Agents; Cell Division; Cells, Cultured; Coculture Techniques; Collagen; Fibroblasts; Gels; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Polymers; RNA, Messenger; Temperature; Tryptophan; Tryptophan Oxygenase | 2004 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neurons; Phenotype; Pregnancy; Quinolinic Acid; Rats; Transaminases; Tryptophan | 2004 |
Increasing production of homocysteine and neopterin and degradation of tryptophan with older age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Dioxygenases; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Macrophages; Male; Middle Aged; Neopterin; T-Lymphocytes; Time Factors; Tryptophan; Vitamin B 12 | 2004 |
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.
Topics: Aminolevulinic Acid; Biochemistry; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Histidine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iron; Isopropyl Thiogalactoside; Kynurenine; Plasmids; Protoporphyrins; Recombinant Proteins; Temperature; Time Factors; Tryptophan; Tryptophan Oxygenase | 2004 |
Tryptophan metabolism; tryptophan, kynurenine, and related compounds as precursors of nicotinic acid.
Topics: Kynurenine; Niacin; Nicotinic Acids; Tryptophan | 1949 |
Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores.
Topics: Alpha-Globulins; Amniotic Fluid; Carrier Proteins; Chromatography, High Pressure Liquid; Dimerization; DNA Adducts; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Kynurenine; Lipocalin 1; Mass Spectrometry; Models, Chemical; Oxidation-Reduction; Oxygen; Protein Binding; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Time Factors; Tryptophan; Ultraviolet Rays | 2004 |
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.
Topics: Abatacept; Antigens, CD; B7-1 Antigen; B7-2 Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Separation; Cell-Free System; Cells, Cultured; Dendritic Cells; Humans; Immunoconjugates; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-2; Kynurenine; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Glycoproteins; Monocytes; Protein Binding; RNA, Messenger; Tryptophan; Tryptophan Oxygenase; Tryptophan-tRNA Ligase; Up-Regulation | 2005 |
Simultaneous measurement of kynurenine and tryptophan in human plasma and supernatants of cultured human cells by HPLC with coulometric detection.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Kynurenine; Plasma; Reproducibility of Results; Tryptophan | 2004 |
Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients.
Topics: Adult; Aged; Aged, 80 and over; Cataract; Chromatography, High Pressure Liquid; Glucosides; Humans; Kynurenine; Lens, Crystalline; Middle Aged; Phenylbutyrates; Tryptophan; Tyrosine; Ultraviolet Rays; Uric Acid | 2004 |
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits.
Topics: Animals; Carboxy-Lyases; Hypercholesterolemia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestine, Small; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Mixed Function Oxygenases; Niacin; Rabbits; Transaminases; Tryptophan; Tryptophan Oxygenase | 2004 |
The damaging effect of UV-C irradiation on lens alpha-crystallin.
Topics: alpha-Crystallins; Animals; Cattle; Chromatography, Gel; Circular Dichroism; Kynurenine; Lens, Crystalline; Molecular Chaperones; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan; Ultraviolet Rays | 2004 |
Mass spectral evidence for carbonate-anion-radical-induced posttranslational modification of tryptophan to kynurenine in human Cu, Zn superoxide dismutase.
Topics: Anions; Carbonates; Chromatography, High Pressure Liquid; Copper; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Kynurenine; Models, Molecular; Oxidation-Reduction; Protein Processing, Post-Translational; Protein Structure, Tertiary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tryptophan; Zinc | 2004 |
Simultaneous determination of tryptophan and kynurenine in serum by HPLC with UV and fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Humans; Kynurenine; Quality Control; Sensitivity and Specificity; Tryptophan | 2004 |
Tryptophan loading induces oxidative stress.
Topics: Adult; Female; Humans; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Molecular Structure; Oxidative Stress; Tryptophan | 2004 |
St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro.
Topics: Cell Survival; Chromatography, High Pressure Liquid; Concanavalin A; Cytokines; Humans; Hypericum; In Vitro Techniques; Indicators and Reagents; Interferon-gamma; Kynurenine; Mitogens; Monocytes; Neopterin; Phytohemagglutinins; Plant Extracts; Tryptophan | 2004 |
Monocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation.
Topics: Adolescent; Adult; Apoptosis; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation; Humans; Kynurenine; Male; Middle Aged; Monocytes; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2005 |
Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma.
Topics: Adolescent; Adult; Bacteremia; Case-Control Studies; Child; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphopenia; Male; Multiple Organ Failure; Prognosis; Prospective Studies; Respiratory Distress Syndrome; Sepsis; Tryptophan; Tryptophan Oxygenase; Wounds and Injuries | 2005 |
Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Concanavalin A; Down-Regulation; Humans; Kynurenine; Leukocytes, Mononuclear; Neopterin; Phytohemagglutinins; Protein Denaturation; Salicylic Acid; Tryptophan | 2005 |
Tryptophan metabolites interfere with the Ehrlich reaction used for the measurement of kynurenine.
Topics: 3-Hydroxyanthranilic Acid; Benzaldehydes; Chromatography, High Pressure Liquid; Humans; Kynurenine; Monocytes; Tryptophan | 2005 |
3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antigens; Arginine; Binding, Competitive; Blotting, Western; Cell Membrane; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Histidine; Humans; Immunohistochemistry; Kynurenine; Lens, Crystalline; Lysine; Magnetic Resonance Spectroscopy; Models, Chemical; Ninhydrin; Oxygen; Protein Conformation; Spectrophotometry; Time Factors; Tryptophan; Water | 2005 |
Tryptophan metabolism and oxidative stress in patients with Huntington's disease.
Topics: Adolescent; Adult; Aged; Aldehydes; Brain; Female; Humans; Huntington Disease; Kynurenine; Male; Malondialdehyde; Middle Aged; Neopterin; Nerve Growth Factors; Oxidative Stress; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tryptophan | 2005 |
Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.
Topics: Animals; Arylformamidase; Gene Silencing; Kidney; Kynurenine; Liver; Lymphocyte Activation; Mice; Mice, Knockout; Niacinamide; Phenotype; Renal Insufficiency; Thymidine Kinase; Tryptophan | 2005 |
Tryptophan degradation in patients with gynecological cancer correlates with immune activation.
Topics: Adult; Age Factors; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Genital Neoplasms, Female; Humans; Immunity, Cellular; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Neopterin; Tryptophan; Tryptophan Oxygenase | 2005 |
Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues.
Topics: Adult; Austria; Depression, Postpartum; Female; Humans; Kynurenine; Labor, Obstetric; Neopterin; Postpartum Period; Pregnancy; Prevalence; Psychiatric Status Rating Scales; Time Factors; Tryptophan; Tryptophan Oxygenase | 2005 |
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.
Topics: Age Factors; Animals; Carboxy-Lyases; Enzymes; Intestine, Small; Kidney; Kynurenine; Liver; Metabolism; Oxygenases; Rats; Rats, Sprague-Dawley; Transaminases; Tryptophan | 2005 |
Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.
Topics: 3-Hydroxyanthranilic Acid; Adult; Animals; Chromatography, High Pressure Liquid; Cystatin B; Cystatins; Disease Models, Animal; Female; Humans; Kynurenine; Male; Mice; Myoclonic Epilepsies, Progressive; Serotonin; Tryptophan | 2005 |
Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy.
Topics: Antibodies, Bacterial; Cohort Studies; Down-Regulation; Environment; Female; Helicobacter pylori; Humans; Hypersensitivity, Immediate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Th2 Cells; Tryptophan | 2006 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Quinolinic Acid; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured; Up-Regulation | 2005 |
Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Interleukin-2; Ionomycin; Ionophores; Kynurenine; Monocytes; Neopterin; Phytohemagglutinins; Resveratrol; Stilbenes; Tryptophan; Tumor Necrosis Factor-alpha | 2005 |
Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjögren's syndrome.
Topics: Antibodies, Antinuclear; beta 2-Microglobulin; Blood Sedimentation; C-Reactive Protein; Chromatography, High Pressure Liquid; Creatinine; Female; Humans; Immunoglobulin A; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Sjogren's Syndrome; Tryptophan | 2005 |
Tryptophan degradation increases with stage in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Health Status; Humans; Kynurenine; Male; Middle Aged; Neopterin; Severity of Illness Index; Tryptophan | 2006 |
Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines.
Topics: 3-Hydroxyanthranilic Acid; Antigen Presentation; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cytokines; Dendritic Cells; Free Radical Scavengers; Homeostasis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melanoma; Neoplasm Proteins; Receptors, Antigen, T-Cell; Tryptophan | 2006 |
Tryptophan metabolite improves symptoms in MS model.
Topics: Animals; Disease Models, Animal; Kynurenine; Mice; Multiple Sclerosis, Relapsing-Remitting; Neuritis, Autoimmune, Experimental; Tryptophan | 2006 |
Tryptophan metabolism and oxidative stress in patients with chronic brain injury.
Topics: Adult; Aged; Brain Injuries; Chromatography, High Pressure Liquid; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Models, Chemical; Neopterin; Nerve Growth Factors; Oxidative Stress; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Tryptophan | 2006 |
Protein oxidation in plant mitochondria detected as oxidized tryptophan.
Topics: Aconitate Hydratase; Amino Acid Sequence; Electrophoresis, Gel, Two-Dimensional; Kynurenine; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Oxidation-Reduction; Plant Leaves; Plant Proteins; Sequence Homology, Amino Acid; Solanum tuberosum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Tryptophan | 2006 |
3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.
Topics: alpha-Crystallins; Animals; Catalysis; Cataract; Cattle; Chromatography, High Pressure Liquid; Cysteine; Humans; Kynurenine; Lens, Crystalline; Mass Spectrometry; Methionine; Oxidation-Reduction; Oxidative Stress; Sunscreening Agents; Tryptophan; Ultraviolet Rays | 2006 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduction; Peptides; Pigmentation; Protein Binding; Proteins; Solubility; Sunscreening Agents; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells.
Topics: 3-Hydroxyanthranilic Acid; Cell Line, Tumor; Cell Separation; Dendritic Cells; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lipopolysaccharides; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Monocytes; Protein Processing, Post-Translational; T-Lymphocytes; Tryptophan | 2006 |
Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality.
Topics: Adult; Aged, 80 and over; Aging; Female; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Longevity; Male; Middle Aged; Models, Biological; T-Lymphocytes; Tryptophan | 2006 |
Kynurenine as an Intermediate in the Formation of Nicotinic Acid from Tryptophane by Neurospora.
Topics: Kynurenine; Neurospora; Niacin; Nicotinic Acids; Tryptophan | 1947 |
Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Antigens, CD; Antigens, Differentiation; CTLA-4 Antigen; Female; Genotype; Helicobacter Infections; Helicobacter pylori; Humans; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Polymorphism, Single Nucleotide; Transforming Growth Factor beta1; Tryptophan | 2007 |
Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients.
Topics: Adult; Bariatric Surgery; Female; Gastroplasty; Humans; Kynurenine; Male; Middle Aged; Neopterin; Obesity, Morbid; Postoperative Period; Satiety Response; Tryptophan; Tryptophan Oxygenase; Weight Loss | 2006 |
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.
Topics: Animals; Antigens, CD; Antigens, Differentiation; CD8-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; CTLA-4 Antigen; Down-Regulation; Female; Forkhead Transcription Factors; Immunophenotyping; Interleukin-10; Kynurenine; Membrane Proteins; Mice; Mice, Inbred DBA; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Mice, Transgenic; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Resting Phase, Cell Cycle; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tryptophan | 2006 |
Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO.
Topics: Animals; CD8 Antigens; Cell Membrane Permeability; Cells, Cultured; Dendritic Cells; Female; Gene Silencing; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mice; Mice, Inbred DBA; Paracrine Communication; Protein Processing, Post-Translational; RNA, Small Interfering; Signal Transduction; Tryptophan | 2006 |
[Simultaneous determination of kynurenine and tryptophan in serum by high performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Humans; Kynurenine; Limit of Detection; Spectrophotometry, Ultraviolet; Tryptophan | 2006 |
Photochemistry of kynurenine, a tryptophan metabolite: properties of the triplet state.
Topics: Acetone; Animals; Crystallins; Humans; Hydrogen-Ion Concentration; Kynurenine; Light; Models, Chemical; Photochemistry; Photolysis; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan; Water | 2005 |
Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients.
Topics: Adult; Anxiety; Depression; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Male; Middle Aged; Tryptophan | 2006 |
Kynurenine--an old pathway retraced.
Topics: Animals; Depressive Disorder, Major; Humans; Hydrolases; Inflammation; Interferons; Kynurenine; ortho-Aminobenzoates; Rats; Review Literature as Topic; Tryptophan | 2006 |
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor.
Topics: Aminobutyrates; Animals; Enzyme Inhibitors; Kynurenine; Rats; Sulfones; Transaminases; Tryptophan | 2006 |
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.
Topics: Antigens, CD; Cells, Cultured; Gene Expression Regulation; GPI-Linked Proteins; Humans; Immunity, Cellular; Indoleamine-Pyrrole 2,3,-Dioxygenase; Killer Cells, Natural; Kynurenine; Lymphocyte Activation; Membrane Glycoproteins; Natural Cytotoxicity Triggering Receptor 1; Natural Cytotoxicity Triggering Receptor 3; NK Cell Lectin-Like Receptor Subfamily K; Receptors, IgG; Receptors, Immunologic; Receptors, Natural Killer Cell; Tryptophan | 2006 |
The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Chromatography, High Pressure Liquid; Cohort Studies; Cotinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Smoking; Statistics, Nonparametric; T-Lymphocytes; Tryptophan | 2006 |
Kynurenine pathway in major depression: evidence of impaired neuroprotection.
Topics: Adult; Depressive Disorder; Female; Humans; Kynurenine; Male; Middle Aged; Neuroprotective Agents; Psychiatric Status Rating Scales; Tryptophan | 2007 |
Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment.
Topics: 3-Hydroxyanthranilic Acid; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Molecular Structure; Neopterin; ortho-Aminobenzoates; Osteoporosis; Sodium Salicylate; Tryptophan | 2006 |
Altered tryptophan metabolism in the brain of cystatin B-deficient mice: a model system for progressive myoclonus epilepsy.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Cystatin B; Cystatins; Disease Models, Animal; Female; Hydroxyindoleacetic Acid; Kynurenine; Male; Mice; Mutation; Phenotype; Serotonin; Synaptic Transmission; Tryptophan; Unverricht-Lundborg Syndrome | 2006 |
The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.
Topics: Alanine Transaminase; Animals; Cloning, Molecular; Cluster Analysis; Computational Biology; Culicidae; Evolution, Molecular; Kynurenine; Kynurenine 3-Monooxygenase; Molecular Structure; Oxidation-Reduction; Phylogeny; Transaminases; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2007 |
Inhibition of creatine kinase activity from rat cerebral cortex by 3-hydroxykynurenine.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Creatine Kinase; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Kynurenine; Mitochondria; Rats; Rats, Wistar; Sulfhydryl Compounds; Tryptophan | 2006 |
Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation.
Topics: Acute Disease; Adult; Aged; Creatinine; Epithelial Cells; Female; Graft Rejection; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Transplantation; Kynurenine; Male; Middle Aged; Neopterin; Tryptophan | 2007 |
Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice.
Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; DNA, Bacterial; Eosinophils; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Limosilactobacillus reuteri; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Probiotics; Toll-Like Receptor 9; Tryptophan | 2007 |
Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation.
Topics: Aedes; Animals; Ascorbic Acid; Enzyme Activation; Hydrogen Peroxide; Kynurenine; Oxidants; Recombinant Proteins; Reducing Agents; Spectrophotometry, Ultraviolet; Sulfites; Superoxides; Tryptophan; Tryptophan Oxygenase | 2007 |
Tryptophan breakdown pathway in bipolar mania.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brief Psychiatric Rating Scale; Female; Gyrus Cinguli; Humans; Kynurenic Acid; Kynurenine; Male; Schizophrenia; Severity of Illness Index; Tryptophan | 2007 |
Malaria parasite induces tryptophan-related immune suppression in mice.
Topics: Animals; Antimalarials; CD4-Positive T-Lymphocytes; Chloroquine; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Plasmodium yoelii; Time Factors; Tryptophan | 2007 |
Two distinct pathways supply anthranilate as a precursor of the Pseudomonas quinolone signal.
Topics: Antibiosis; Artificial Gene Fusion; beta-Galactosidase; Chorismic Acid; Gene Deletion; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Kynurenine; Metabolic Networks and Pathways; Microbial Viability; Models, Biological; ortho-Aminobenzoates; Pseudomonas aeruginosa; Quinolones; Staphylococcus aureus; Tryptophan | 2007 |
Diminished quality of life in patients with cancer correlates with tryptophan degradation.
Topics: Aged; Disease Progression; Fatigue; Female; Humans; Immunity, Cellular; Karnofsky Performance Status; Kynurenine; Male; Middle Aged; Neoplasms; Neopterin; Prognosis; Quality of Life; Survival Analysis; Tryptophan | 2007 |
Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease.
Topics: Biopsy; Celiac Disease; Child; Child, Preschool; Chromatography, High Pressure Liquid; Crohn Disease; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant; Interferon-gamma; Interleukin-10; Intestinal Mucosa; Intestine, Small; Kynurenine; Male; Transforming Growth Factor beta; Tryptophan | 2007 |
High throughput analysis of tryptophan metabolites in a complex matrix using capillary electrophoresis coupled to time-of-flight mass spectrometry.
Topics: Cerebrospinal Fluid; Coated Materials, Biocompatible; Electroosmosis; Electrophoresis, Capillary; Humans; Kynurenine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan | 2007 |
Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Graft Rejection; Hindlimb; Immune Tolerance; Immunosuppressive Agents; Injections, Intramuscular; Kynurenine; Models, Animal; Rats; Rats, Inbred Lew; Tacrolimus; Tissue Transplantation; Tryptophan | 2007 |
Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS.
Topics: Acrolein; Aldehydes; Amino Acid Sequence; Apolipoprotein B-100; Chloroform; Chromatography, Liquid; Copper Sulfate; Cysteine; Electrophoresis, Polyacrylamide Gel; Histidine; Humans; Kynurenine; Lipoproteins, LDL; Lysine; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Polyvinyls; Tandem Mass Spectrometry; Trypsin; Tryptophan | 2007 |
Influence of kynurenines in pathogenesis of cataract formation in tryptophan-deficient regimen in Wistar rats.
Topics: Animals; Antioxidants; Cataract; Diet; Kynurenine; Lens, Crystalline; Microscopy, Fluorescence; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tryptophan | 2007 |
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response.
Topics: Astrocytes; Cells, Cultured; Cytokines; Cytomegalovirus; Cytomegalovirus Infections; Encephalitis, Viral; Gene Expression Regulation, Enzymologic; HIV Infections; HIV-1; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Inducers; Interferon Regulatory Factor-3; Kynurenine; Ligands; Macrophages; Membrane Glycoproteins; Microglia; NF-kappa B; Nitric Oxide; Oxidoreductases Acting on CH-CH Group Donors; Poly I-C; Proteins; Toll-Like Receptor 3; Tryptophan; Viral Envelope Proteins; Virus Replication | 2007 |
Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, CD; Antigens, Differentiation; CTLA-4 Antigen; Dendritic Cells; Diabetes Mellitus; Female; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred DBA; Paracrine Communication; Phenotype; T-Lymphocytes, Regulatory; Tryptophan | 2007 |
Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO).
Topics: Amino Acid Motifs; Animals; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Software; Substrate Specificity; Tryptophan | 2007 |
Plasma kynurenine and related measures in tic disorder patients.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Humans; Hydrocortisone; Kynurenine; Male; Middle Aged; Neopterin; Tic Disorders; Tryptophan | 2007 |
Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season.
Topics: Adult; Female; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lupus Erythematosus, Systemic; Male; Middle Aged; Seasons; Severity of Illness Index; Sunlight; Tryptophan | 2007 |
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection.
Topics: Animals; Antigens, CD; Antigens, Differentiation; CTLA-4 Antigen; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-2 Receptor alpha Subunit; Intestines; Kynurenine; Macaca mulatta; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Spleen; T-Lymphocytes, Regulatory; Tryptophan; Virus Replication | 2007 |
Altered kynurenine metabolism correlates with infarct volume in stroke.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Brain Infarction; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Lipid Peroxidation; Male; Models, Biological; Neopterin; Nerve Growth Factors; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Statistics as Topic; Stroke; Time Factors; Tomography, X-Ray Computed; Tryptophan | 2007 |
Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.
Topics: Animals; Biosensing Techniques; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Cytosol; Fluorescence Resonance Energy Transfer; Humans; Immune Tolerance; Kynurenine; Large Neutral Amino Acid-Transporter 1; Nanotechnology; T-Lymphocytes; Tryptophan | 2007 |
HCV patients, psychopathology and tryptophan metabolism: analysis of the effects of pegylated interferon plus ribavirin treatment.
Topics: Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon alpha-2; Interferon-alpha; Kynurenine; Macrophages; Male; Middle Aged; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tryptophan | 2007 |
Effect of Kidney-replenishing herb on the indoleamine 2,3-dioxygenase of human syncytiotrophoblasts cultured in vitro and the balance of helper T-cell cytokines.
Topics: Animals; Coculture Techniques; Codonopsis; Culture Media, Conditioned; Cytokines; Embryo Culture Techniques; Enzyme Inhibitors; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Kynurenine; Plants, Medicinal; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; T-Lymphocytes, Helper-Inducer; Trophoblasts; Tryptophan | 2007 |
Differential immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO) on primary human CD4+ and CD8+ T cells.
Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Flow Cytometry; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Protein Serine-Threonine Kinases; T-Lymphocyte Subsets; Tryptophan | 2008 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2007 |
[Mutations in structural genes of tryptophan metabolic enzymes of the kynurenine pathway modulate some units of the L-glutamate receptor--actin cytoskeleton signaling cascade].
Topics: Actins; Animals; Brain; Cytoskeleton; Drosophila melanogaster; Drosophila Proteins; Eye Proteins; Kynurenine; Mutation; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2007 |
The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma.
Topics: Animals; Cell Line, Tumor; Chickens; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Macrophages; NAD; Nitric Oxide; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Transcription, Genetic; Tryptophan | 2008 |
Tryptophan metabolism; concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid.
Topics: Animals; Kynurenic Acid; Kynurenine; Mammals; Niacin; Nicotinic Acids; Tryptophan | 1949 |
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Chronic Disease; Disease Models, Animal; Granulomatous Disease, Chronic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-17; Kynurenine; Lung; Lung Diseases, Fungal; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Reactive Oxygen Species; Receptors, Antigen, T-Cell, gamma-delta; Superoxides; T-Lymphocytes; Tryptophan | 2008 |
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cytokinins; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Hindlimb Suspension; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Minocycline; Motor Activity; Swimming; Time Factors; Tryptophan | 2009 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Disease Models, Animal; Electroencephalography; Encephalitis, Viral; Hippocampus; Kynurenine; Measles virus; Mice; Mice, Inbred BALB C; Microglia; Monitoring, Physiologic; Nerve Degeneration; Neuroglia; Pyramidal Cells; Quinolinic Acid; Seizures; Tryptophan | 2008 |
Quality of life and immune activation in patients with HIV-infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Depression; Disease Progression; Female; Health Status Indicators; Hemoglobins; HIV Infections; Humans; Immunity; Kynurenine; Male; Middle Aged; Neopterin; Predictive Value of Tests; Psychological Tests; Quality of Life; Regression Analysis; Surveys and Questionnaires; Tryptophan; Viral Load | 2008 |
Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.
Topics: Animals; Cells, Cultured; Clonal Anergy; Cytokines; Enzyme Inhibitors; Female; Galactosylceramides; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mice; Mice, Inbred C57BL; Spleen; T-Lymphocyte Subsets; Tryptophan | 2008 |
Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice.
Topics: Animals; Calcium; Cell Line, Tumor; Crystallography, X-Ray; Cytokines; Dose-Response Relationship, Drug; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Nude; Models, Molecular; Molecular Conformation; Pterins; Spectroscopy, Fourier Transform Infrared; Suspensions; Transplantation, Heterologous; Tryptophan | 2008 |
Changes in brain tryptophan metabolism elicited by ageing, social environment, and psychological stress in mice.
Topics: Aging; Amygdala; Animals; Brain; Brain Chemistry; Hippocampus; Kynurenine; Male; Mice; Mice, Inbred ICR; Prefrontal Cortex; Raphe Nuclei; Serotonin; Social Isolation; Stress, Psychological; Tryptophan | 2008 |
Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Bipolar Disorder; Brain; Chromatography, High Pressure Liquid; Female; Gyrus Cinguli; Humans; Kynurenine; Middle Aged; Niacinamide; Predictive Value of Tests; Schizophrenia; Signal Transduction; Suicide; Tryptophan; Tryptophan Oxygenase | 2008 |
An oxidized tryptophan facilitates copper binding in Methylococcus capsulatus-secreted protein MopE.
Topics: Bacterial Outer Membrane Proteins; Bacterial Proteins; Binding Sites; Cloning, Molecular; Copper; Escherichia coli; Kinetics; Kynurenine; Ligands; Methylococcus; Models, Molecular; Molecular Conformation; Oxygen; Protein Binding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan | 2008 |
Study of the plasmatic levels of tryptophan and kynurenine throughout pregnancy.
Topics: Case-Control Studies; Female; Humans; Kynurenine; Pregnancy; Tryptophan | 2008 |
Non-peptidic delta-opioid receptor antagonists suppress mitogen-induced tryptophan degradation in peripheral blood mononuclear cells in vitro.
Topics: Cells, Cultured; Humans; Kynurenine; Leukocytes; Mitosis; Molecular Structure; Peptides; Receptors, Opioid, delta; Structure-Activity Relationship; Tryptophan | 2008 |
High serum tryptophan concentration in pollinosis patients is associated with unresponsiveness to pollen extract therapy.
Topics: Adult; Biomarkers; Desensitization, Immunologic; Enzyme-Linked Immunosorbent Assay; Female; Humans; Kynurenine; Male; Neopterin; Pollen; Rhinitis, Allergic, Seasonal; Tryptophan | 2008 |
Tryptophan oxidation by singlet molecular oxygen [O2(1Deltag)]: mechanistic studies using 18O-labeled hydroperoxides, mass spectrometry, and light emission measurements.
Topics: Chromatography, High Pressure Liquid; Hydrogen Peroxide; Kynurenine; Luminescent Measurements; Molecular Structure; Oxidation-Reduction; Oxygen Isotopes; Photochemistry; Singlet Oxygen; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan | 2008 |
Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure.
Topics: Acute Disease; Animals; Kynurenine; Ligation; Lymph; Male; Mesentery; Multiple Organ Failure; Neutrophils; Pancreatitis; Proteome; Rats; Rats, Sprague-Dawley; Respiratory Burst; Tryptophan | 2008 |
Kynurenine pathway in psychosis: evidence of increased tryptophan degradation.
Topics: Adult; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Male; Middle Aged; Psychotic Disorders; Schizophrenia; Severity of Illness Index; Tryptophan; Up-Regulation | 2009 |
High expression of indoleamine 2,3-dioxygenase gene in prostate cancer.
Topics: Aged; Aged, 80 and over; Cytokines; Gene Expression; Gene Expression Profiling; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neoplasm Proteins; Polymerase Chain Reaction; Prostatic Hyperplasia; Prostatic Neoplasms; Tryptophan | 2008 |
Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study.
Topics: Adult; Aged; Atherosclerosis; Cardiovascular Diseases; Female; Health; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Risk Factors; Tryptophan | 2008 |
Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients' sera by HPLC and is inducible by IFN-gamma.
Topics: Blast Crisis; Chromatography, High Pressure Liquid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukemia, Myeloid, Acute; Lymphocyte Activation; Survival Rate; Transcriptional Activation; Tryptophan; Tumor Cells, Cultured | 2009 |
Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.
Topics: Animals; Body Weight; Cytokines; Gene Expression; Hippocampus; Hypothalamus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Mice; RNA, Messenger; Time Factors; Tryptophan | 2008 |
High-cell-density regulation of the Pseudomonas aeruginosa type III secretion system: implications for tryptophan catabolites.
Topics: Bacterial Proteins; Gene Expression Regulation, Bacterial; Indoleacetic Acids; Kynurenine; Mutation; Protein Transport; Pseudomonas aeruginosa; Tryptophan; Virulence Factors | 2008 |
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compounds; Free Radical Scavengers; Hydrazines; Inflammation; Kynurenine; Magnetic Resonance Imaging; Mass Spectrometry; Nitric Oxide; Nitrites; Nitrosation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Oxadiazoles; Quinones; Tryptophan | 2008 |
Cell cycle arrest by kynurenine in lens epithelial cells.
Topics: Actins; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flow Cytometry; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lens, Crystalline; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Myosin Type II; Tryptophan | 2008 |
Dietary tryptophan helps to preserve tryptophan homeostasis in pigs suffering from lung inflammation.
Topics: Animals; Antioxidants; Diet; Dietary Supplements; Female; Haptoglobins; Homeostasis; Kynurenine; Male; Pneumonia; Random Allocation; Swine; Swine Diseases; Time Factors; Tryptophan; Weight Gain | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Major; Female; Humans; Interferon-gamma; Irritable Bowel Syndrome; Kynurenine; Mental Disorders; Tryptophan | 2008 |
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.
Topics: Adult; Age Factors; Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Inflammation; Kidney Failure, Chronic; Kynurenine; Logistic Models; Male; Middle Aged; Oxidative Stress; Peroxides; Prevalence; Risk Assessment; Risk Factors; Sex Factors; Superoxide Dismutase; Tryptophan | 2009 |
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation.
Topics: Adjuvants, Immunologic; B7-1 Antigen; Cell Differentiation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Enzyme Inhibitors; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oligodeoxyribonucleotides; Plasma Cells; T-Lymphocytes, Regulatory; Toll-Like Receptor 9; Tryptophan; Up-Regulation | 2008 |
[Effect of mutation-induced excess brain concentration of intermediates of the kynurenine pathway of tryptophan metabolism on stress resistance and courtship behavior and communicative sound production in male Drosophila melanogaster].
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Drosophila melanogaster; Kynurenine; Male; Stress, Physiological; Tryptophan; Vocalization, Animal | 2008 |
Concerning the mechanism of the mammalian conversion of tryptophan into kynurenine, kynurenic acid, and nicotinic acid.
Topics: Animals; Kynurenic Acid; Kynurenine; Mammals; Niacin; Nicotinic Acids; Tryptophan | 1948 |
Tryptophan degradation in multiple trauma patients: survivors compared with non-survivors.
Topics: Adult; Aged; Biomarkers; Epidemiologic Methods; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Multiple Trauma; Prognosis; Tryptophan; Young Adult | 2009 |
Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice.
Topics: Amygdala; Animals; Brain; Hippocampus; Housing, Animal; Kynurenine; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Prefrontal Cortex; Raphe Nuclei; Serotonin; Social Isolation; Tryptophan | 2009 |
The 14kDa protein molecule isolated from garlic suppresses indoleamine 2, 3-dioxygenase metabolites in mononuclear cells in vitro.
Topics: Animals; Cell Proliferation; Cell Survival; Chromatography, High Pressure Liquid; Garlic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Plant Extracts; Proteins; Tryptophan | 2008 |
Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Injury Severity Score; Kinetics; Kynurenine; Male; Middle Aged; Multiple Organ Failure; Sepsis; Time Factors; Tryptophan; Wounds and Injuries; Young Adult | 2009 |
Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Iron Chelating Agents; Kynurenine; Methicillin-Resistant Staphylococcus aureus; Picolinic Acids; Time Factors; Tryptophan | 2009 |
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cohort Studies; Enzyme Activation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Irritable Bowel Syndrome; Kynurenine; Male; Middle Aged; Neopterin; Tryptophan; Young Adult | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia | 2009 |
Delta9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro.
Topics: Cannabidiol; Cannabinoid Receptor Antagonists; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Interferon-alpha; Kynurenine; Leukocytes, Mononuclear; Lipopolysaccharides; Mitogens; Morpholines; Neopterin; Pyrazoles; Statistics, Nonparametric; Tryptophan | 2009 |
Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Hepatocytes; Kynurenine; Male; Niacinamide; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tritium; Tryptophan; Water | 2009 |
Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Middle Aged; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2009 |
Acid-induced change in ozone-reactive site in indole ring of tryptophan.
Topics: Acids; Hydrogen-Ion Concentration; Indoles; Kynurenine; Ozone; Tryptophan | 2009 |
Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-therapy-treated hemophilia A mice.
Topics: Animals; Apoptosis; Autoantibodies; Blotting, Western; CD28 Antigens; Cell Line; Cells, Cultured; Factor VIII; Flow Cytometry; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Hemophilia A; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Injections, Intravenous; Kynurenine; Liver; Mice; Plasmids; Signal Transduction; T-Lymphocytes; Transposases; Tryptophan | 2009 |
Reassessment of the reaction mechanism in the heme dioxygenases.
Topics: Catalysis; Chemistry, Organic; Dioxygenases; Heme; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kinetics; Kynurenine; Models, Chemical; Mutagenesis, Site-Directed; Oxygen; Protons; Tryptophan; Tryptophan Oxygenase | 2009 |
Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques.
Topics: Animals; Anti-Retroviral Agents; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Enzyme Inhibitors; Flow Cytometry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Macaca mulatta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; T-Lymphocytes; Transforming Growth Factor beta; Tryptophan; Viremia | 2009 |
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens.
Topics: Animals; Apoptosis; Cataract; Glutathione; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lens, Crystalline; Mice; Mice, Transgenic; Tryptophan | 2009 |
Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells.
Topics: Anti-Inflammatory Agents; Antioxidants; Cacao; Cells, Cultured; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Lipopolysaccharides; Mitogens; Neopterin; Phytohemagglutinins; Plant Extracts; Seeds; Th1 Cells; Tryptophan | 2009 |
Immunological detection of N-formylkynurenine in oxidized proteins.
Topics: Animals; Antibodies; Haptens; Humans; Immune Sera; Immunization; Immunoassay; Kynurenine; Light; Mass Spectrometry; Milk; Myoglobin; Ovalbumin; Oxidation-Reduction; Proteins; Rabbits; Sensitivity and Specificity; Superoxide Dismutase; Superoxide Dismutase-1; Tryptophan | 2009 |
Increased TTS abrogates IDO-mediated CD4(+) T cells suppression in patients with Graves' disease.
Topics: Adult; CD4-Positive T-Lymphocytes; Female; Gene Expression Regulation, Enzymologic; Graves Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphocyte Culture Test, Mixed; Male; Middle Aged; RNA, Messenger; Tryptophan; Tryptophan-tRNA Ligase | 2009 |
Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products.
Topics: Alcohols; Animals; Cattle; Chickens; Electron Spin Resonance Spectroscopy; Free Radicals; Glycine max; Hydrogen Peroxide; Hydrolysis; Kynurenine; Mass Spectrometry; Muramidase; Oxidation-Reduction; Oxidative Stress; Protein Binding; Protein Processing, Post-Translational; Serum Albumin, Bovine; Singlet Oxygen; Soybean Proteins; Tryptophan | 2009 |
Simultaneous determination of tryptophan and kynurenine in plasma samples of children patients with Kawasaki disease by high-performance liquid chromatography with programmed wavelength ultraviolet detection.
Topics: Adolescent; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Mucocutaneous Lymph Node Syndrome; Spectrophotometry, Ultraviolet; Tryptophan | 2009 |
Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Melatonin; Oxidative Stress; Schizophrenia; Serotonin; Tryptophan; Young Adult | 2010 |
Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-17; Kynurenine; Mice; Mice, Inbred DBA; Peptide Fragments; Th1 Cells; Tryptophan | 2009 |
Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer.
Topics: Aged; Disease Progression; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Male; Middle Aged; Prognosis; Tryptophan | 2010 |
High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients.
Topics: Adult; Aged, 80 and over; Bacteremia; Chromatography, High Pressure Liquid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Tryptophan; Young Adult | 2010 |
Tissue factor/its pathway inhibitor system and kynurenines in chronic kidney disease patients on conservative treatment.
Topics: Adult; Aged; Case-Control Studies; Chronic Disease; Female; Humans; Kidney Diseases; Kynurenine; Lipoproteins; Male; Middle Aged; Thromboplastin; Tryptophan | 2009 |
Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease.
Topics: Coronary Artery Disease; Depression; Enzyme Activation; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Physical Fitness; Tryptophan | 2009 |
Changes in serum tryptophan catabolism as an indicator of disease activity in adult T-cell leukemia/lymphoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Doxorubicin; Drug Monitoring; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia-Lymphoma, Adult T-Cell; Metabolic Networks and Pathways; Neoplasm Proteins; Neoplastic Cells, Circulating; Neutropenia; Nitrosourea Compounds; Prednisone; Receptors, Interleukin-2; Tryptophan; Tryptophan Oxygenase; Vincristine; Vindesine | 2009 |
Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells.
Topics: Apoptosis; Cell Line; Cell Proliferation; Culture Media, Conditioned; Cytokines; Endothelium, Corneal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Large Neutral Amino Acid-Transporter 1; Oligonucleotide Array Sequence Analysis; Subcellular Fractions; T-Lymphocytes; Tissue Culture Techniques; Transforming Growth Factor beta2; Tryptophan; Up-Regulation | 2009 |
The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects.
Topics: Bacteria; Cell Line; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enterococcus; Enzyme Activation; HeLa Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Staphylococcus aureus; T-Lymphocytes; Time Factors; Tryptophan | 2009 |
Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase.
Topics: Animals; Coculture Techniques; Culture Media, Conditioned; Gene Expression; HeLa Cells; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Isoantigens; Kynurenine; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Simplexvirus; Staphylococcus aureus; T-Lymphocytes; Tetracycline; Toxoplasma; Transfection; Tryptophan; Tryptophan Oxygenase | 2009 |
[Tryptophan and its metabolites in renal allograft recipients].
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Quinolinic Acid; Reference Values; Tryptophan; Urea | 2009 |
Increased tryptophan degradation in patients with bronchus carcinoma.
Topics: Blood Sedimentation; C-Reactive Protein; Carcinoma, Non-Small-Cell Lung; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neoplasm Proteins; Neopterin; Pilot Projects; Small Cell Lung Carcinoma; Tryptophan | 2010 |
Fluorescence and coloration of grey hair.
Topics: Hair Color; Humans; Kynurenine; Spectrometry, Fluorescence; Tryptophan | 2009 |
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
Topics: Adult; Antifibrinolytic Agents; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Fibrinolysin; Hemostasis; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Peptide Fragments; Peritoneal Dialysis, Continuous Ambulatory; Plasminogen Activator Inhibitor 1; Poland; Prevalence; Prothrombin; Quinolinic Acid; Receptors, Urokinase Plasminogen Activator; Thromboplastin; Tryptophan; Urokinase-Type Plasminogen Activator | 2010 |
The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Aspartic Acid; Brain; Brain Mapping; Choline; Depression; Female; Humans; Kynurenine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neural Pathways; Psychiatric Status Rating Scales; Statistics, Nonparametric; Tryptophan; Young Adult | 2010 |
Indoleamine 2,3-dioxygenase in lung allograft tolerance.
Topics: Biomarkers; Bronchiolitis Obliterans; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Follow-Up Studies; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-8; Kynurenine; Lung Transplantation; Postoperative Complications; Reference Values; T-Lymphocyte Subsets; Time Factors; Transplantation Tolerance; Transplantation, Homologous; Tryptophan | 2009 |
Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: identification of subgroups with immune responses and blood-CSF barrier dysfunction.
Topics: Adult; Cohort Studies; Female; Humans; Immunoglobulins; International Classification of Diseases; Kynurenine; Male; Middle Aged; Mood Disorders; Neopterin; Psychiatric Status Rating Scales; Schizophrenia; Statistics, Nonparametric; Tomography, X-Ray Computed; Tryptophan | 2010 |
Evidence for a ferryl intermediate in a heme-based dioxygenase.
Topics: Computer Simulation; Crystallography, X-Ray; Dioxygenases; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Spectrum Analysis, Raman; Tryptophan | 2009 |
Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.
Topics: Animals; Apoptosis; Bone Marrow Transplantation; Clonal Anergy; Graft vs Host Disease; Immune Tolerance; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tryptophan | 2009 |
[Impact of interferon alpha immunotherapy on tryptophan metabolism in patients with chronic hepatitis C. Results of a pilot studies on ten patients].
Topics: Adult; Antiviral Agents; Anxiety Disorders; Blood Platelets; Depressive Disorder; Female; Hepatitis C, Chronic; Humans; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Kynurenine; Male; Middle Aged; Personality Inventory; Pilot Projects; Polyethylene Glycols; Recombinant Proteins; Serotonin; Tryptophan | 2009 |
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis C; Humans; Interferon-alpha; Kynurenine; Longitudinal Studies; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type II; Ribavirin; Statistics as Topic; Tryptophan | 2010 |
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Quinolinic Acid; Signal Transduction; Spinal Cord; Tryptophan | 2010 |
The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine.
Topics: Animals; Animals, Genetically Modified; Biological Transport, Active; Drosophila melanogaster; Eye; Female; Kynurenine; Longevity; Mutation; Pigmentation; Species Specificity; Time Factors; Tryptophan; Tryptophan Oxygenase | 2010 |
Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Kynurenine; Lens, Crystalline; Rats; Rats, Wistar; Tryptophan | 2009 |
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan | 2009 |
[Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer].
Topics: Adult; Age Factors; Breast Neoplasms; Chromatography, High Pressure Liquid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Tryptophan | 2009 |
Rational design of indoleamine 2,3-dioxygenase inhibitors.
Topics: Animals; Cell Proliferation; Cells, Cultured; Drug Design; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Models, Molecular; Small Molecule Libraries; Structure-Activity Relationship; Tryptophan | 2010 |
Optimization of Zn2+-containing mobile phase for simultaneous determination of kynurenine, kynurenic acid and tryptophan in human plasma by high performance liquid chromatography.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Fluorescence; Humans; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Middle Aged; Tryptophan; Young Adult; Zinc | 2010 |
Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors.
Topics: Amidines; Animals; Cell Line, Tumor; Dogs; Enzyme Inhibitors; Female; Humans; Immune System; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred BALB C; Neoplasms; Tryptophan | 2010 |
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.
Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free Life; Inflammation; Interleukin-10; Kynurenine; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Transgenic; Principal Component Analysis; Tryptophan; Urine | 2010 |
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
Topics: Animals; Brain; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Hydroxyindoleacetic Acid; Kynurenine; Lung; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Serotonin; Stress, Psychological; Tryptophan | 2010 |
Regulation of myeloperoxidase-specific T cell responses during disease remission in antineutrophil cytoplasmic antibody-associated vasculitis: the role of Treg cells and tryptophan degradation.
Topics: Acute Disease; Aged; Antibodies, Antineutrophil Cytoplasmic; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunosuppressive Agents; Kynurenine; Lymphocyte Count; Male; Middle Aged; Neopterin; Peroxidase; Remission Induction; T-Lymphocytes, Regulatory; Tryptophan; Vasculitis | 2010 |
Simultaneous determination of serum tryptophan metabolites in patients with systemic lupus erythematosus by high performance liquid chromatography with fluorescence detection.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Male; Middle Aged; Tryptophan | 2010 |
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Endotoxemia; Enzyme Activation; Guanylate Cyclase; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Plasmodium berghei; Rats; Rats, Inbred SHR; Tryptophan | 2010 |
Ido brings down the pressure in systemic inflammation.
Topics: Animals; Blood Pressure; Coronary Vessels; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Tryptophan | 2010 |
Mass spectrometric identification of oxidative modifications of tryptophan residues in proteins: chemical artifact or post-translational modification?
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Artifacts; Chromatography, Liquid; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Humans; Kynurenine; Mice; Molecular Sequence Data; Oxidation-Reduction; Peptide Mapping; Protein Processing, Post-Translational; Proteomics; Tandem Mass Spectrometry; Trypsin; Tryptophan | 2010 |
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.
Topics: Age Factors; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Huntingtin Protein; Huntington Disease; Kynurenine; Metabolic Diseases; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; Time Factors; Tritium; Tryptophan | 2010 |
Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients.
Topics: Adult; Critical Illness; Female; Humans; Kynurenine; Male; Middle Aged; NAD; Renal Insufficiency; Sepsis; Tryptophan | 2010 |
The possible role of the kynurenine pathway in adolescent depression with melancholic features.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Child; Cytokines; Depressive Disorder; Depressive Disorder, Major; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Neurotoxins; Reference Values; Tryptophan; Young Adult | 2010 |
Melatonin and elimination of kynurenines in children with Down's syndrome.
Topics: Child; Child, Preschool; Circadian Rhythm; Down Syndrome; Female; Humans; Kynurenic Acid; Kynurenine; Male; Melatonin; ortho-Aminobenzoates; Oxidative Stress; Serotonin; Tryptophan | 2010 |
Insights into therapy: tryptophan oxidation and HIV infection.
Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Progression; Enzyme Inhibitors; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interleukin-17; Kynurenine; Oxidation-Reduction; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Tryptophan; Viral Load | 2010 |
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigmoid; Dendritic Cells; Disease Progression; HIV Infections; HIV Seropositivity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interferon-gamma; Interleukin-17; Kynurenine; Lipopolysaccharides; Lymph Nodes; Prospective Studies; Rectum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors; Tryptophan; Up-Regulation; Viral Load | 2010 |
The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Brain Ischemia; Free Radical Scavengers; Humans; Inflammation; Kynurenine; Male; Stroke; Tryptophan | 2010 |
Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism--effects of medication.
Topics: Adolescent; Amino Acids; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Child; Cytokines; Energy Metabolism; Female; Humans; Kynurenine; Male; Nerve Growth Factors; Neuroglia; Pilot Projects; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tryptophan | 2010 |
Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease.
Topics: Cells, Cultured; Chromatography, Liquid; Dose-Response Relationship, Drug; Granulomatous Disease, Chronic; Humans; Immunoblotting; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kinetics; Kynurenine; Leukocytes; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Spectrometry, Mass, Electrospray Ionization; Superoxides; Time Factors; Tryptophan | 2010 |
Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Child; Cytokines; Female; Humans; Interleukins; Kynurenine; Linear Models; Male; Motor Activity; Neuroglia; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychomotor Performance; Reaction Time; Tryptophan | 2010 |
Tryptophan metabolism in allergic rhinitis: the effect of pollen allergen exposure.
Topics: Adult; Allergens; Biomarkers; Female; Humans; Kynurenine; Male; Neopterin; Pollen; Rhinitis, Allergic, Seasonal; Tryptophan | 2010 |
Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression.
Topics: Antigens, CD; Base Sequence; Cell Communication; CTLA-4 Antigen; Decidua; DNA Primers; Female; Humans; Immune Tolerance; In Vitro Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Killer Cells, Natural; Kynurenine; Lipopolysaccharide Receptors; Myeloid Cells; Pregnancy; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tryptophan | 2010 |
Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease.
Topics: Antigens, CD; Child; Child, Preschool; Dendritic Cells; Female; Granulomatous Disease, Chronic; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lipopolysaccharides; Male; Tryptophan | 2010 |
Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chronic Disease; Colitis; Cytokines; Hippocampus; Kynurenine; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Proteomics; RNA, Messenger; Trichuriasis; Trichuris; Tryptophan; Vagotomy; Vagus Nerve | 2010 |
Candida albicans dampens host defense by downregulating IL-17 production.
Topics: 5-Hydroxytryptophan; Candida albicans; Cells, Cultured; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Host-Pathogen Interactions; Hot Temperature; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Interleukin-1beta; Kynurenine; Leukocytes, Mononuclear; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Hydroxylase; Tumor Necrosis Factor-alpha | 2010 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2010 |
High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death.
Topics: Animals; Antiviral Agents; Cell Death; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Fibroblasts; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Keratinocytes; Kynurenine; Protein Serine-Threonine Kinases; Proteins; RNA, Small Interfering; Signal Transduction; T-Lymphocytes; Transcription Factor CHOP; Tryptophan | 2010 |
Relationship between an increased serum kynurenine/tryptophan ratio and atherosclerotic parameters in hemodialysis patients.
Topics: Adult; Aged; Ankle Brachial Index; Atherosclerosis; Carotid Arteries; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney Failure, Chronic; Kynurenine; Male; Middle Aged; Renal Dialysis; Time Factors; Tryptophan; Tunica Intima; Tunica Media; Young Adult | 2010 |
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.
Topics: Adenocarcinoma; Animals; Blotting, Western; Disease Progression; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Male; Mice; Prostatic Neoplasms; Tryptophan | 2010 |
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Dendritic Cells; Dose-Response Relationship, Immunologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Receptors, Aryl Hydrocarbon; Signal Transduction; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tryptophan | 2010 |
Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Olanzapine; Schizophrenia; Tryptophan; Up-Regulation; Young Adult | 2012 |
Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection.
Topics: Acute Disease; Adult; Aged; Biopsy; Female; Graft Rejection; Humans; Kidney Cortex Necrosis; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine; Male; Middle Aged; Predictive Value of Tests; Prognosis; Transplantation, Homologous; Tryptophan | 2010 |
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells.
Topics: Acute Disease; Adult; Biocatalysis; Blotting, Western; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Humans; Immunophenotyping; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Myeloid; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Tryptophan; Tumor Cells, Cultured | 2010 |
Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers.
Topics: Adult; Aged; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-2 Receptor alpha Subunit; Interleukin-6; Kynurenine; Middle Aged; Neopterin; Ovarian Neoplasms; Receptors, Tumor Necrosis Factor; Tryptophan | 2011 |
Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy.
Topics: Adenoviridae; Animals; Ankle Joint; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Genetic Therapy; Genetic Vectors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Kynurenine; Macrophages; Rats; Rats, Sprague-Dawley; Synovial Membrane; Tryptophan | 2011 |
Kynurenine inhibits chondrocyte proliferation and is increased in synovial fluid of patients with septic arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Infectious; C-Reactive Protein; Cell Proliferation; Cells, Cultured; Chondrocytes; Female; Humans; Kynurenine; Male; Middle Aged; Prospective Studies; ROC Curve; Synovial Fluid; Tryptophan | 2010 |
Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Optical Rotation; Pyrazoles; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan | 2010 |
NFκB-dependent increase of kynurenine pathway activity in human placenta: inhibition by sulfasalazine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Cytokines; Female; Gene Expression Regulation, Developmental; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-1; Interleukin-6; Kynurenine; Lipopolysaccharides; NF-kappa B; Organ Culture Techniques; Placenta; Pregnancy; Pregnancy Complications, Infectious; RNA, Messenger; Sulfasalazine; Tryptophan; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha | 2010 |
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.
Topics: Adult; Antiviral Agents; Case-Control Studies; Depression; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon alpha-2; Interferon-alpha; Italy; Kynurenine; Male; Middle Aged; Polyethylene Glycols; Psychiatric Status Rating Scales; Recombinant Proteins; Ribavirin; Serotonin; Time Factors; Treatment Outcome; Tryptophan | 2011 |
Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond.
Topics: Cells, Cultured; Dendritic Cells; Humans; Immune Tolerance; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; T-Lymphocytes, Regulatory; Tryptophan; Tryptophan Oxygenase | 2011 |
Toward an alternative intrinsic probe for spectroscopic characterization of a protein.
Topics: Animals; Cattle; Electron Transport; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Kynurenine; Models, Molecular; Protein Conformation; Proteins; Spectrometry, Fluorescence; Tryptophan | 2010 |
Enhanced degradation of tryptophan in patients on hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Austria; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Enzyme Activation; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neopterin; Quality of Life; Renal Dialysis; Treatment Outcome; Tryptophan; Uremia; Young Adult | 2010 |
Simultaneous determination of tryptophan, kynurenine and 5-hydroxytryptamine by HPLC: Application in uremic patients undergoing hemodialysis.
Topics: Chromatography, High Pressure Liquid; Humans; Kynurenine; Renal Dialysis; Reproducibility of Results; Serotonin; Tryptophan | 2011 |
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression; Inflammation; Kynurenic Acid; Kynurenine; Male; Mice; Neuroglia; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Probenecid; Purinones; Receptors, G-Protein-Coupled; Spinal Cord; Tryptophan | 2011 |
Determination of tryptophan and kynurenine in human plasma by liquid chromatography-electrochemical detection with multi-wall carbon nanotube-modified glassy carbon electrode.
Topics: Chromatography, High Pressure Liquid; Electrochemical Techniques; Electrodes; Humans; Kynurenine; Nanotubes, Carbon; Reproducibility of Results; Tryptophan | 2011 |
Evidence for a key role of the peripheral kynurenine pathway in the modulation of anxiety- and depression-like behaviours in mice: focus on individual differences.
Topics: Amygdala; Animals; Anxiety; Brain; Depression; Gyrus Cinguli; Kynurenine; Male; Maze Learning; Mice; Mice, Inbred BALB C; Models, Animal; Serotonin; Signal Transduction; Stress, Physiological; Swimming; Tryptophan | 2011 |
Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis.
Topics: Animals; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Interactions; Hydrolases; Interferon-gamma; Iron Chelating Agents; Kynurenine; L-Lactate Dehydrogenase; Mice; Microglia; Motor Neurons; Picolinic Acids; Signal Transduction; Time Factors; Tryptophan; Tryptophan Oxygenase | 2011 |
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
Topics: Animals; Epididymis; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infertility, Male; Inflammation; Kynurenine; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Specificity; Spermatozoa; Tryptophan; Ubiquitination | 2011 |
[Indoleamine 2,3-dioxygenase activity during chemotherapy or hormone therapy in patients with breast cancer].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Letrozole; Middle Aged; Nitriles; Paclitaxel; Triazoles; Tryptophan | 2010 |
Tryptophan degradation and serum neopterin concentrations in intensive care unit patients.
Topics: Aged; APACHE; Biomarkers; Critical Care; Female; Humans; Immune System; Kynurenine; Male; Middle Aged; Multiple Organ Failure; Neopterin; Systemic Inflammatory Response Syndrome; Tryptophan | 2011 |
Synthesis of peptides containing 5-hydroxytryptophan, oxindolylalanine, N-formylkynurenine and kynurenine.
Topics: 5-Hydroxytryptophan; Alanine; Amino Acid Sequence; Humans; Kynurenine; Molecular Sequence Data; Molecular Structure; Oxidation-Reduction; Oxindoles; Peptides; Tryptophan | 2011 |
Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain; Hippocampus; Kynurenine; Male; Mice; Mice, Inbred ICR; Prefrontal Cortex; Raphe Nuclei; Rats; Serotonin; Stress, Psychological; Tryptophan | 2011 |
The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cognition Disorders; Cross-Sectional Studies; Enzyme Activation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; ROC Curve; Stroke; Tryptophan | 2011 |
High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
Topics: Adult; Aged; Biomarkers; Blood Cell Count; C-Reactive Protein; Creatinine; Female; Hemorrhagic Fever with Renal Syndrome; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Prospective Studies; Puumala virus; Renal Insufficiency; Severity of Illness Index; Tryptophan; Young Adult | 2011 |
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice.
Topics: Animals; Arterioles; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Mice; Mice, Knockout; Motor Activity; Nitric Oxide Synthase Type II; Reperfusion Injury; Tryptophan | 2011 |
Increased indoleamine 2,3-dioxygenase (IDO) activity in idiopathic generalized epilepsy.
Topics: Adult; Epilepsy, Generalized; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Serotonin; Tryptophan | 2011 |
Comparative study on kynurenic acid production in the rat striatum by tryptophan enantiomers: an in vivo microdialysis study.
Topics: Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Corpus Striatum; D-Amino-Acid Oxidase; Kynurenic Acid; Kynurenine; Male; Microdialysis; Models, Chemical; Pyrazoles; Rats; Rats, Sprague-Dawley; Time Factors; Tryptophan | 2011 |
Decreased IDO activity and increased TTS expression break immune tolerance in patients with immune thrombocytopenia.
Topics: Adult; Aged; Antigens, CD19; Autoimmune Diseases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Female; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharide Receptors; Male; Middle Aged; Real-Time Polymerase Chain Reaction; Thrombocytopenia; Tryptophan; Tryptophan-tRNA Ligase | 2011 |
Tryptophan degradation and neopterin levels in treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Disease Progression; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Tryptophan; Tumor Necrosis Factor-alpha | 2012 |
Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: evidence from the Young Finns study.
Topics: Adult; Atherosclerosis; Carotid Artery Diseases; Depression; Dioxygenases; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Longitudinal Studies; Male; Psychiatric Status Rating Scales; Risk Factors; Sex Factors; Tryptophan; Tryptophan-tRNA Ligase; Women; Young Adult | 2011 |
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Cytokines; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Hypericum; Impulsive Behavior; Inflammation; Kynurenine; Male; Middle Aged; Neopterin; Phytotherapy; Recurrence; Serotonin; Smoking; Suicide, Attempted; Thiophenes; Tryptophan; Young Adult | 2011 |
Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients.
Topics: Adult; Algorithms; Antipsychotic Agents; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Patient Discharge; Schizophrenia; Schizophrenic Psychology; Spectrophotometry, Ultraviolet; Treatment Outcome; Tryptophan | 2011 |
Immunological mechanisms to establish embryo tolerance in early bovine pregnancy.
Topics: Animals; Cattle; Cells, Cultured; Coculture Techniques; Embryo Implantation; Embryo, Mammalian; Endometrium; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Immune Tolerance; Immunohistochemistry; In Situ Hybridization; Indoleamine-Pyrrole 2,3,-Dioxygenase; Insemination, Artificial; Kynurenine; Leukocytes; Pregnancy; RNA, Messenger; Tandem Mass Spectrometry; Tryptophan; Up-Regulation | 2011 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington Disease; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Nerve Degeneration; Neuroprotective Agents; Tryptophan; Tryptophan Oxygenase | 2011 |
Enantiomeric separation of D,L-tryptophan and D,L-kynurenine by HPLC using pre-column fluorescence derivatization with R(-)-DBD-PyNCS.
Topics: Chromatography, High Pressure Liquid; Fluorescent Dyes; Isothiocyanates; Kynurenine; Oxadiazoles; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tryptophan | 2011 |
Human myeloid dendritic cells are refractory to tryptophan metabolites.
Topics: Antibodies; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Dendritic Cells; Flow Cytometry; Humans; Immunity, Cellular; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Macrophages; Membrane Glycoproteins; Monocytes; Quinolinic Acid; Receptors, Cell Surface; Receptors, Immunologic; T-Lymphocytes, Regulatory; Tryptophan | 2011 |
High tryptophan diet reduces extracellular dopamine release via kynurenic acid production in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Corpus Striatum; Diet; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Homovanillic Acid; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Microdialysis; Rats; Rats, Wistar; Statistics, Nonparametric; Tryptophan | 2011 |
Serum tryptophan and kynurenine concentrations as parameters for indoleamine 2,3-dioxygenase activity in patients with endometrial, ovarian, and vulvar cancer.
Topics: Adult; Aged; Albumins; Case-Control Studies; Female; Genital Neoplasms, Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Tryptophan | 2011 |
An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.
Topics: Cohort Studies; Cytokines; Endothelium, Vascular; Female; Humans; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Count; Male; Microvessels; Middle Aged; Models, Biological; Sepsis; Severity of Illness Index; Tryptophan | 2011 |
Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells.
Topics: Cells, Cultured; Cyclosporine; GTP Cyclohydrolase; Humans; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Methylprednisolone; Mycophenolic Acid; Neopterin; Phytohemagglutinins; Sirolimus; Tacrolimus; Tryptophan | 2011 |
Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypotension; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Parenteral Nutrition, Total; Prospective Studies; Shock, Septic; Tryptophan; Young Adult | 2011 |
Simultaneous determination of tryptophan, kynurenine, kynurenic and xanthurenic acids in honey by liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection.
Topics: Chromatography, Liquid; Formates; Honey; Kynurenic Acid; Kynurenine; Methanol; Reproducibility of Results; Sensitivity and Specificity; Spain; Tandem Mass Spectrometry; Tryptophan; Xanthurenates | 2011 |
Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Community-Acquired Infections; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Pneumonia; Prognosis; Severity of Illness Index; Tryptophan; Young Adult | 2011 |
An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD).
Topics: Adult; Alcohol Drinking; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Child; Child Care; Cytokines; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Kynurenine; Male; Mothers; Pregnancy; Pregnancy Complications; Smoking; Tryptophan | 2011 |
Determination of neopterin, kynurenine, tryptophan and creatinine in human serum by high throuput HPLC.
Topics: Buffers; Chromatography, High Pressure Liquid; Creatinine; Humans; Hydrogen-Ion Concentration; Kynurenine; Neopterin; Phosphates; Reproducibility of Results; Tryptophan | 2011 |
Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.
Topics: Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Cognition; Coronary Artery Bypass; Enzyme-Linked Immunosorbent Assay; Extracorporeal Circulation; Female; Humans; Inflammation; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Neopterin; Nerve Growth Factors; Neuropsychological Tests; Postoperative Complications; Predictive Value of Tests; Psychomotor Performance; Reproducibility of Results; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Stroop Test; Thoracic Surgical Procedures; Trail Making Test; Tryptophan; Tumor Necrosis Factor-alpha; Verbal Learning | 2011 |
Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity.
Topics: Adult; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Crohn Disease; Female; Humans; Immunoenzyme Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Tryptophan; Young Adult | 2012 |
L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin.
Topics: Adenoviridae; Animal Feed; Animals; Aromatic-L-Amino-Acid Decarboxylases; Fatty Liver; Fibrosis; Fructose; Genetic Predisposition to Disease; Hepatocytes; Kynurenine; Lipids; Male; Mice; Mice, Inbred C57BL; Serotonin; TOR Serine-Threonine Kinases; Triglycerides; Tryptophan | 2011 |
Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy.
Topics: Animals; Anorexia; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Blood-Brain Barrier; Brain; Cell Line; Cytokines; Depression; Encephalitis; Ginsenosides; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Mice; Neuropsychological Tests; Panax; Serotonin; Tissue Distribution; Tryptophan; Weight Loss | 2011 |
[Simultaneous determination of tryptophan and its key metabolites by high performance liquid chromatography with programmed wavelength ultraviolet detection].
Topics: Adolescent; Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Depression; Female; Humans; Kynurenine; Male; Serotonin; Spectrophotometry, Ultraviolet; Tryptophan; Young Adult | 2011 |
Simultaneous determination of urinary tryptophan, tryptophan-related metabolites and creatinine by high performance liquid chromatography with ultraviolet and fluorimetric detection.
Topics: Adult; Chromatography, High Pressure Liquid; Creatinine; Drug Stability; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Linear Models; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 2011 |
Sequencing and biological effects of an adipokinetic/hypertrehalosemic peptide in the stick insect, Baculum extradentatum.
Topics: Animals; Chromatography, Reverse-Phase; Heart; Insect Hormones; Kynurenine; Locusta migratoria; Male; Neuropeptides; Oligopeptides; Pyrrolidonecarboxylic Acid; Tryptophan | 2012 |
Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
Topics: Anti-Bacterial Agents; Chlamydia trachomatis; Dose-Response Relationship, Drug; Doxycycline; Epithelial Cells; HeLa Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Time Factors; Tryptophan | 2011 |
[Metabolic footprint in conditioned culture medium of placental explants: a comparison between early-onset and late-onset severe preeclampsia].
Topics: Chorionic Villi; Culture Media, Conditioned; Female; Humans; In Vitro Techniques; Kynurenine; Ornithine; Placenta; Pre-Eclampsia; Pregnancy; Tryptophan | 2011 |
KynR, a Lrp/AsnC-type transcriptional regulator, directly controls the kynurenine pathway in Pseudomonas aeruginosa.
Topics: Bacterial Proteins; Gene Expression Regulation, Bacterial; Kynurenine; Operon; Pseudomonas aeruginosa; Transcription Factors; Tryptophan | 2011 |
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
Topics: Animals; Autocrine Communication; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Disease Progression; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kynurenine; Ligands; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Paracrine Communication; Receptors, Aryl Hydrocarbon; Tryptophan; Tryptophan Oxygenase | 2011 |
Mass spectrometric characterization of peptides containing different oxidized tryptophan residues.
Topics: 5-Hydroxytryptophan; Alanine; Amino Acid Sequence; Animals; Kynurenine; Molecular Sequence Data; Muscle Proteins; Oxidation-Reduction; Oxindoles; Peptides; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan | 2011 |
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Liver; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Signal Transduction; Transaminases; Tryptophan; Tryptophan Oxygenase | 2011 |
Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients.
Topics: Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Female; Gene Expression; Humans; India; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Retina; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Tryptophan | 2011 |
Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase.
Topics: Adolescent; Adult; Aged; Chromatography, Liquid; Gene Expression Regulation, Enzymologic; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Intestines; Kynurenine; Mass Spectrometry; Middle Aged; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Time Factors; Transplantation, Homologous; Tryptophan; Young Adult | 2011 |
Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity.
Topics: Aldosterone; Analysis of Variance; Animals; Body Weight; Brain; Calcium-Binding Proteins; Catecholamines; Chromatography, High Pressure Liquid; Corticosterone; Depression; Diet; Disease Models, Animal; DNA-Binding Proteins; Kynurenic Acid; Kynurenine; Male; Nerve Tissue Proteins; Nucleobindins; Paroxetine; Protein Binding; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Swimming; Time Factors; Tritium; Tryptophan | 2012 |
The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*.
Topics: Acute Disease; Aged; Brain Diseases; Critical Illness; Female; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Prospective Studies; Tryptophan | 2012 |
Sepsis and hypotension: enter kynurenine, move over nitric oxide.
Topics: Female; Humans; Hypotension; Kynurenine; Male; Shock, Septic; Tryptophan | 2011 |
The impact of photo-induced molecular changes of dairy proteins on their ACE-inhibitory peptides and activity.
Topics: Amino Acid Sequence; Amino Acids; Angiotensin-Converting Enzyme Inhibitors; Caseins; Kynurenine; Milk Proteins; Oxidants, Photochemical; Oxidation-Reduction; Peptide Fragments; Peptidyl-Dipeptidase A; Photochemical Processes; Protein Carbonylation; Proteolysis; Riboflavin; Sequence Analysis, Protein; Sulfhydryl Compounds; Tryptophan; Whey Proteins | 2012 |
Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Chromatography, Liquid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; ROC Curve; Serum; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan; Tuberculosis, Pulmonary | 2012 |
Tryptophan catabolism via kynurenine production in Streptomyces coelicolor: identification of three genes coding for the enzymes of tryptophan to anthranilate pathway.
Topics: Arylformamidase; Hydrolases; Kynurenine; Metabolic Networks and Pathways; Streptomyces coelicolor; Tryptophan; Tryptophan Oxygenase | 2012 |
Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenine; Liver; Male; Rats; Tryptophan; Tumor Necrosis Factor-alpha | 2012 |
The mechanism of substrate inhibition in human indoleamine 2,3-dioxygenase.
Topics: Biochemistry; Catalysis; Chemistry, Pharmaceutical; Heme; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Mutagenesis, Site-Directed; Oxygen; Protein Binding; Substrate Specificity; Thermodynamics; Tryptophan | 2012 |
Blood pressure reducing effects of Phalaris canariensis in normotensive and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Kynurenine; Male; Phalaris; Plant Extracts; Prehypertension; Rats; Rats, Inbred SHR; Rats, Wistar; Sympathetic Nervous System; Time Factors; Tryptophan | 2012 |
The kynurenine pathway: a metabolinomic pathway for intensive care unit delirium?*.
Topics: Brain Diseases; Female; Humans; Kynurenine; Male; Tryptophan | 2012 |
Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway.
Topics: Adult; Analysis of Variance; Biomarkers; Chi-Square Distribution; Depression; Female; Humans; International Classification of Diseases; Kynurenic Acid; Kynurenine; Male; Middle Aged; Principal Component Analysis; Psychiatric Status Rating Scales; Somatoform Disorders; Tryptophan | 2012 |
L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice.
Topics: Acute Disease; Animals; Cardiovirus Infections; Encephalomyocarditis virus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Type I; Kynurenine; Male; Mice; Mice, Knockout; Myocarditis; Myocardium; Signal Transduction; Spleen; Survival Rate; Tryptophan; Viral Load; Virus Replication | 2012 |
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.
Topics: Animals; Antipsychotic Agents; Clozapine; Kynurenine; Male; ortho-Aminobenzoates; Oxidative Stress; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Social Isolation; Tryptophan | 2012 |
Kynurenic acid and 3-hydroxykynurenine production from D-kynurenine in mice.
Topics: Animals; Brain Chemistry; Catalysis; Female; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred Strains; Stereoisomerism; Tryptophan | 2012 |
Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation.
Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Stereoisomerism; Tryptophan | 2012 |
Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in weaned pigs.
Topics: Amino Acid Transport Systems; Animals; Diquat; Herbicides; Hypothalamus; Intestinal Mucosa; Kynurenine; Liver; Malondialdehyde; Oxidative Stress; Random Allocation; RNA, Messenger; Sequence Analysis, DNA; Serotonin; Swine; Tryptophan; Tryptophan Oxygenase; Weaning | 2012 |
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone.
Topics: Adipose Tissue; Adult; Blood Pressure; Case-Control Studies; Cell Count; Female; Homeostasis; Humans; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Middle Aged; Obesity; Omentum; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan | 2012 |
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2012 |
Kynurenine and hypotension: historic perspectives.
Topics: Female; Humans; Hypotension; Kynurenine; Male; Shock, Septic; Tryptophan | 2012 |
Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia.
Topics: Adult; Female; Humans; Kynurenine; Norway; Overweight; Pre-Eclampsia; Pregnancy; Prevalence; Risk; Tryptophan; Young Adult | 2012 |
Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells.
Topics: Adult; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Decidua; Endometriosis; Endometrium; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Stromal Cells; Tryptophan; Young Adult | 2012 |
On the autofluorescence of fingermarks.
Topics: beta Carotene; Bilirubin; Chlorophyll; Chromatography, Thin Layer; Dermatoglyphics; Flavin-Adenine Dinucleotide; Fluorescence; Humans; Kynurenine; Light; Phenylalanine; Pheophytins; Protoporphyrins; Riboflavin; Sebum; Spectrometry, Fluorescence; Sweat; Thiamine; Tryptophan; Tyrosine; Ultraviolet Rays; Vitamin B 6; Xanthurenates | 2012 |
Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation.
Topics: Adult; Biomarkers; C-Reactive Protein; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Real-Time Polymerase Chain Reaction; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Tryptophan | 2012 |
Simultaneous analysis of kynurenine and tryptophan in human plasma by capillary electrophoresis with UV detection.
Topics: Aged; Electrophoresis, Capillary; Female; Humans; Kynurenine; Male; Middle Aged; Spectrophotometry, Ultraviolet; Tryptophan | 2012 |
Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice.
Topics: Animals; Chromatography, High Pressure Liquid; Down-Regulation; Doxorubicin; Eosine Yellowish-(YS); Hematoxylin; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Male; Mice; Mice, Inbred BALB C; Periodic Acid; Renal Insufficiency; RNA, Messenger; Schiff Bases; Time Factors; Tryptophan | 2012 |
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Female; Humans; Hyperparathyroidism, Primary; Immunity, Cellular; Immunologic Factors; Inflammation; Interferon-gamma; Kynurenine; Longitudinal Studies; Male; Middle Aged; Monitoring, Immunologic; Neopterin; ortho-Aminobenzoates; Parathyroidectomy; Postoperative Care; Risk Factors; Tryptophan; Vitamin B 6 | 2012 |
Assessment of immunotoxicity parameters in individuals occupationally exposed to lead.
Topics: Adult; Biomarkers; Cytokines; Genetic Association Studies; Humans; Immunosuppressive Agents; Industry; Kynurenine; Lead; Lead Poisoning; Lymphocyte Subsets; Male; Middle Aged; Neopterin; Occupational Exposure; Polymorphism, Genetic; Porphobilinogen Synthase; Portugal; Receptors, Calcitriol; Smoking; Spain; Tryptophan | 2012 |
Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice.
Topics: Animal Structures; Animals; Biopterins; Kynurenine; Male; Malondialdehyde; Mice; Nitric Oxide; Oxidative Stress; Toxoplasma; Toxoplasmosis, Animal; Tryptophan | 2012 |
Modulatory effects of acupuncture on murine depression-like behavior following chronic systemic inflammation.
Topics: Acupuncture Therapy; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Chronic Disease; Depression; Dopamine; Inflammation; Kynurenine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Tryptophan | 2012 |
Specific immunotherapy normalizes tryptophan concentrations in patients with allergic rhinitis.
Topics: Adult; Cytokines; Female; Humans; Immunization, Secondary; Immunotherapy; Kynurenine; Male; Neopterin; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Th1-Th2 Balance; Tryptophan; Vaccines | 2012 |
Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.
Topics: Adult; Cell Line; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Male; Middle Aged; Orientia tsutsugamushi; Scrub Typhus; Serum; Tryptophan | 2012 |
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue.
Topics: Acetylcholinesterase; Animals; Binding, Competitive; Catalytic Domain; Cholinesterase Inhibitors; Edrophonium; Electric Organ; Hydrolysis; Kynurenine; Mass Spectrometry; Methylene Blue; Models, Molecular; Oxidation-Reduction; Photochemistry; Photosensitizing Agents; Propidium; Protein Conformation; Singlet Oxygen; Structure-Activity Relationship; Substrate Specificity; Torpedo; Tryptophan; Water | 2012 |
Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.
Topics: Animals; Behavior, Animal; Brain; CX3C Chemokine Receptor 1; Depression; Hydroxyindoleacetic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Mice; Microglia; Motor Activity; Receptors, Cytokine; Receptors, HIV; Serotonin; Tryptophan | 2013 |
Indoleamine 2,3-dioxygenase activity and expression in patients with chronic lymphocytic leukemia.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Tryptophan | 2012 |
Evaluation of tetrahydrobiopterin pathway in operating room workers: changes in biopterin status and tryptophan metabolism.
Topics: Adult; Air Pollutants, Occupational; Anesthetics; Biopterins; Female; Humans; Kynurenine; Male; Occupational Exposure; Operating Rooms; Serotonin; Tryptophan | 2012 |
Systemic metabolism of tryptophan and its catabolites, kynurenine and 3-HAA, in mice with inflammatory arthritis.
Topics: 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; Catalysis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Male; Mice; Tryptophan | 2013 |
An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; Gene Expression Regulation; Hydrolases; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Lymph Nodes; Mice; Mice, Inbred DBA; Organ Specificity; ortho-Aminobenzoates; RNA, Messenger; Signal Transduction; Spleen; Tryptophan | 2012 |
Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.
Topics: Animals; Antineoplastic Agents; Brain; Cachexia; Carcinoma; Cell Line, Tumor; Cidofovir; Cytokines; Cytosine; Female; Human papillomavirus 16; Humans; Kynurenine; Leukocyte Count; Liver; Mice; Mice, Nude; Organophosphonates; Papillomavirus Infections; Spleen; Splenomegaly; Tryptophan; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2013 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan | 2013 |
Development of a fluorescent chemosensor for the detection of kynurenine.
Topics: Chromatography, High Pressure Liquid; Fluorescence; Fluorescent Dyes; Humans; Kynurenine; Molecular Structure; Tryptophan | 2013 |
Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Hydrogen Peroxide; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Lactobacillus; Rats; Rats, Inbred BB; Serotonin; Tryptophan | 2013 |
The kynurenine pathway: a missing piece in the puzzle of valproate action?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Ibuprofen; Kynurenic Acid; Kynurenine; Male; Rats; Signal Transduction; Tryptophan; Valproic Acid | 2013 |
Neopterin and kynurenine-tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study.
Topics: Aged; Biomarkers; Coronary Artery Disease; Female; Follow-Up Studies; Health Surveys; Humans; Kynurenine; Male; Neopterin; Norway; Prospective Studies; Tryptophan | 2013 |
Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus.
Topics: Animals; Doublecortin Protein; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Hippocampus; Kynurenine; Neurogenesis; Neuronal Plasticity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Signal Transduction; Tryptophan | 2013 |
Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection.
Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Female; Gastrointestinal Tract; Indoleacetic Acids; Kynurenine; Male; Melatonin; Rats; Rats, Wistar; Serotonin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 2012 |
Investigation of the kynurenine pathway in Indoleamine 2, 3 dioxygenase deficient mice with inflammatory arthritis.
Topics: Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; DNA Primers; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Metabolic Networks and Pathways; Mice; Mice, Knockout; Real-Time Polymerase Chain Reaction; Tryptophan | 2013 |
Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
Topics: Aging; Anhedonia; Animals; Behavior, Animal; Body Weight; Chronic Disease; Depression; Hindlimb Suspension; Illness Behavior; Inflammation; Kynurenine; Lung; Mice; Mice, Inbred BALB C; Motor Activity; Mycobacterium bovis; Mycobacterium Infections; Spleen; Tryptophan | 2013 |
UV-radiation induced disruption of dry-cavities in human γD-crystallin results in decreased stability and faster unfolding.
Topics: Cataract; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Kynurenine; Molecular Dynamics Simulation; Protein Stability; Protein Unfolding; Tryptophan; Tyrosine; Ultraviolet Rays | 2013 |
Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Line; Cell Survival; Dopamine; Fabaceae; Glutamic Acid; HIV; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Melatonin; Molecular Structure; Plant Extracts; Psychotropic Drugs; Seeds; Serotonin; Tryptophan; Virus Replication | 2013 |
Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Topics: Animals; Blotting, Western; Cell Differentiation; Enzyme Inhibitors; Flow Cytometry; Gene Knockdown Techniques; Interleukin-17; Kynurenine; Kynurenine 3-Monooxygenase; Ligands; Metabolism; Mice; Mice, Inbred BALB C; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Th17 Cells; Tryptophan | 2013 |
Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Flow Cytometry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza A virus; Kynurenine; Lung; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Tryptophan | 2013 |
Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene.
Topics: Adult; Aged; Depressive Disorder, Major; Female; Humans; Hydroxyindoleacetic Acid; Immunogenetics; Interferon-gamma; Kynurenine; Male; Middle Aged; Polymorphism, Genetic; Serotonin; Tryptophan | 2013 |
Activation of indoleamine 2,3-dioxygenase by LPS in a porcine model.
Topics: Animals; Blood Cells; Cells, Cultured; Enzyme Activation; Feasibility Studies; Humans; Immune System Diseases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Interleukin-10; Kynurenine; Lipopolysaccharides; Liver; Lung; Male; Models, Animal; Swine; Tryptophan; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates | 2013 |
Towards an insight on photodamage in hair fibre by UV-light: An experimental and theoretical study.
Topics: Hair; Humans; Kynurenine; Molecular Dynamics Simulation; Spectrometry, Fluorescence; Tryptophan; Ultraviolet Rays | 2013 |
Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome.
Topics: Adolescent; Adult; Age Factors; Aged; C-Reactive Protein; Child; Female; Humans; Interleukin-6; Kynurenine; Male; Metabolic Syndrome; Middle Aged; Neopterin; Obesity; Observational Studies as Topic; Tryptophan; Young Adult | 2014 |
Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Aged; Aged, 80 and over; Alzheimer Disease; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Carboxy-Lyases; Case-Control Studies; Cerebellum; Cerebral Cortex; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metabolic Networks and Pathways; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Organ Specificity; Pentosyltransferases; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tryptophan; Tryptophan Oxygenase | 2013 |
Serum levels and activity of indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase and their association with disease severity in patients with chronic kidney disease.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Glomerular Filtration Rate; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Renal Insufficiency, Chronic; Tryptophan; Tryptophan-tRNA Ligase | 2013 |
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2013 |
A simple LC-MS/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients.
Topics: Chromatography, Liquid; HIV; HIV Infections; Humans; Kynurenine; Limit of Detection; Tandem Mass Spectrometry; Tryptophan | 2013 |
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2013 |
Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure.
Topics: Adult; Chemical Hazard Release; Endocrine Disruptors; Endocrine System; Environmental Exposure; Environmental Restoration and Remediation; Female; Humans; Hydrocortisone; Immune System; Kynurenine; Lymphocyte Subsets; Male; Neopterin; Occupational Exposure; Petroleum Pollution; Prolactin; Spain; Tryptophan | 2013 |
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Topics: Acute Disease; Adenosine Triphosphate; Adolescent; Analysis of Variance; Biomarkers; CD4-Positive T-Lymphocytes; Child; Communicable Diseases; Down-Regulation; Drug Monitoring; Female; Graft Rejection; Humans; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney Transplantation; Kynurenine; Longitudinal Studies; Male; Mass Spectrometry; Monitoring, Immunologic; Predictive Value of Tests; Prospective Studies; Time Factors; Treatment Outcome; Tryptophan; Up-Regulation | 2013 |
Kynurenine increases matrix metalloproteinase-1 and -3 expression in cultured dermal fibroblasts and improves scarring in vivo.
Topics: Animals; Cells, Cultured; Cicatrix, Hypertrophic; Dermatologic Agents; Dermis; Disease Models, Animal; Ear, External; Female; Fibroblasts; Foreskin; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Rabbits; Tryptophan | 2014 |
The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells.
Topics: Cell Line; Cell Line, Tumor; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Real-Time Polymerase Chain Reaction; Skin; Tryptophan | 2013 |
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokines; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Nitric Oxide; ortho-Aminobenzoates; Peroxidase; Picornaviridae Infections; Prospective Studies; Quinolinic Acid; Rhinovirus; Tryptophan; Young Adult | 2013 |
Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography.
Topics: Coronary Angiography; Coronary Artery Disease; Female; Humans; Kynurenine; Male; Middle Aged; Myocardial Infarction; Risk Factors; Stroke; Tryptophan | 2013 |
A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.
Topics: Animals; Brain; Contraceptives, Oral; Female; Humans; Hydrolases; Intestines; Kynurenic Acid; Kynurenine; Liver; Mice; Models, Theoretical; Muscles; ortho-Aminobenzoates; Rats; Transaminases; Tryptophan; Tryptophan Oxygenase; Vitamin B 6 Deficiency | 2013 |
C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.
Topics: Biomarkers; Breast Neoplasms; C-Reactive Protein; Cytokines; Depression; Fatigue; Female; Humans; Inflammation; Kynurenine; Middle Aged; Tryptophan | 2013 |
The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes.
Topics: Animals; Cells, Cultured; Host-Pathogen Interactions; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Listeria monocytogenes; Listeriosis; Mice; Myeloid Cells; RNA, Small Interfering; Species Specificity; Tryptophan; Up-Regulation | 2014 |
Immuno-regulatory function of indoleamine 2,3 dioxygenase through modulation of innate immune responses.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Coculture Techniques; Enzyme Induction; Graft Rejection; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Islets of Langerhans; Islets of Langerhans Transplantation; Jurkat Cells; Kynurenine; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Rats; Rats, Long-Evans; Tryptophan | 2013 |
A biopsychosocial model of interferon-alpha-induced depression in patients with chronic hepatitis C infection.
Topics: Adult; Analysis of Variance; Depressive Disorder; Female; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Interview, Psychological; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; Neuropsychological Tests; Personal Satisfaction; Prospective Studies; Psychiatric Status Rating Scales; Quality of Life; Risk Factors; Sex Factors; Social Support; Surveys and Questionnaires; Thyroid Function Tests; Tryptophan | 2013 |
Structural characterization of new microcystins containing tryptophan and oxidized tryptophan residues.
Topics: Alanine; Chromatography, Liquid; Kynurenine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microcystins; Microcystis; Oxidation-Reduction; Oxindoles; Tandem Mass Spectrometry; Tryptophan | 2013 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2013 |
Tryptophan metabolite analog, N-(3,4-dimethoxycinnamonyl) anthranilic acid, ameliorates acute graft-versus-host disease through regulating T cell proliferation and polarization.
Topics: Animals; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Female; Graft vs Host Disease; Intestine, Large; Intestine, Small; Kynurenine; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; ortho-Aminobenzoates; Skin; T-Lymphocytes, Regulatory; Tryptophan | 2013 |
Concurrent quantification of tryptophan and its major metabolites.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Rabbits; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2013 |
[Simultaneous determination of tryptophan and its metabolites in plasma by high performance liquid chromatography with on-column derivatization].
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Pregnancy; Reproducibility of Results; Tryptophan; Tyrosine; Zinc Acetate | 2013 |
Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B.
Topics: Cyclization; Kynurenine; Molecular Conformation; Ozone; Peptides; Peptides, Cyclic; Resins, Synthetic; Tryptophan | 2013 |
Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisy.
Topics: Aged; Aged, 80 and over; Biomarkers; Chromatography, Liquid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Pleural Effusion; Prospective Studies; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan; Tuberculosis, Pleural; Up-Regulation | 2013 |
Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data.
Topics: Humans; Kinetics; Kynurenine; Liver; Metabolic Networks and Pathways; Models, Theoretical; Organ Specificity; Transcriptome; Tryptophan | 2013 |
Exercise affects symptom severity but not biological measures in depression and somatization - results on IL-6, neopterin, tryptophan, kynurenine and 5-HIAA.
Topics: Adult; Case-Control Studies; Depression; Exercise; Female; Humans; Hydroxyindoleacetic Acid; Interleukin-6; Kynurenine; Male; Middle Aged; Neopterin; Severity of Illness Index; Somatoform Disorders; Tryptophan | 2013 |
Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans.
Topics: alpha-Tocopherol; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Electron Transport Complex II; Female; Fusion Regulatory Protein-1; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Large Neutral Amino Acid-Transporter 1; Male; Metabolic Networks and Pathways; Mitochondria; Neoplastic Stem Cells; Signal Transduction; Tryptophan | 2014 |
Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain.
Topics: Animals; Brain; Gene Deletion; Gene Knockout Techniques; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Mice; Mice, Knockout; Organ Specificity; Tryptophan | 2013 |
Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans.
Topics: Adult; Antiretroviral Therapy, Highly Active; Depression; Female; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Metabolic Networks and Pathways; Plasma; Treatment Outcome; Tryptophan; Uganda | 2014 |
Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.
Topics: Animals; Apoptosis; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Tryptophan; Up-Regulation | 2014 |
Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report.
Topics: Adult; Bipolar Disorder; Female; Humans; Kynurenine; Male; Middle Aged; Overweight; Tryptophan | 2014 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan | 2014 |
Dissecting the contributions of β-hairpin tyrosine pairs to the folding and stability of long-lived human γD-crystallins.
Topics: Alanine; Cataract; Cations; gamma-Crystallins; Humans; Hydrophobic and Hydrophilic Interactions; Kynurenine; Models, Molecular; Molecular Dynamics Simulation; Mutation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Tryptophan; Tyrosine; Ultraviolet Rays | 2014 |
Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk.
Topics: Adult; Aged; Biomarkers, Tumor; Case-Control Studies; Cohort Studies; Europe; Female; Humans; Kynurenine; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Risk Factors; Surveys and Questionnaires; Tryptophan | 2014 |
[Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].
Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Tryptophan | 2013 |
A tryptophan metabolite, kynurenine, promotes mast cell activation through aryl hydrocarbon receptor.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Humans; Immunoglobulin E; Kynurenine; Mast Cells; Mice; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan | 2014 |
[Screening of urinary biomarkers in patients with type 2 diabetes mellitus].
Topics: Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Tryptophan | 2013 |
Evaluation of lipopeptide (daptomycin) aggregation using fluorescence, light scattering, and nuclear magnetic resonance spectroscopy.
Topics: Anti-Bacterial Agents; Calcium Signaling; Daptomycin; Drug Stability; Fluorescence Resonance Energy Transfer; Hot Temperature; Hydrogen-Ion Concentration; Ionophores; Kinetics; Kynurenic Acid; Kynurenine; Nephelometry and Turbidimetry; Nuclear Magnetic Resonance, Biomolecular; Osmolar Concentration; Particle Size; Protein Stability; Solubility; Spectrophotometry, Ultraviolet; Tryptophan | 2014 |
A biological basis for depression in pancreatic cancer.
Topics: Adenocarcinoma; Affect; Aged; Aged, 80 and over; Depression; Female; Humans; Kynurenine; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms; Risk Factors; Signal Transduction; Surveys and Questionnaires; Tryptophan; Tumor Burden | 2014 |
Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour.
Topics: Allopurinol; Animals; Antidepressive Agents; Cerebral Cortex; Chronic Disease; Corticosterone; Depressive Disorder; Disease Models, Animal; Enzyme Inhibitors; Kynurenine; Liver; Male; Neuropsychological Tests; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Stress, Psychological; Tryptophan; Tryptophan Oxygenase; Weight Gain | 2014 |
Do endothelial cells eat tryptophan to die?
Topics: Animals; Apoptosis; Endothelium, Vascular; Humans; Kynurenine; NADPH Oxidases; Tryptophan | 2014 |
Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome.
Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Enzyme Activation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Transgenic; Receptors, Leptin; Tryptophan | 2014 |
Association of increased indoleamine 2, 3-dioxygenase with impaired natural killer cell activity in hemodialysis patients.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Killer Cells, Natural; Kynurenine; Male; Middle Aged; Receptors, Interleukin-2; Renal Dialysis; Selenium; T-Lymphocytes; Tryptophan; Zinc | 2014 |
Suppression of experimental autoimmune glomerulonephritis by tryptophan.
Topics: 3-Hydroxyanthranilic Acid; Animals; Anti-Glomerular Basement Membrane Disease; Apoptosis; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Free Radical Scavengers; Glomerular Filtration Rate; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Proteinuria; Rats; Rats, Inbred WKY; Th1 Cells; Th2 Cells; Tryptophan | 2014 |
Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study.
Topics: Aged; Biomarkers; Bone Density; Female; Humans; Inflammation; Inflammation Mediators; Interferon-gamma; Kynurenine; Male; Metabolic Networks and Pathways; Metabolome; Middle Aged; Neopterin; Risk Factors; Tryptophan | 2014 |
The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Female; HIV Infections; Humans; Kynurenine; Male; Tryptophan; Uganda | 2014 |
Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral; CD4 Antigens; CD8-Positive T-Lymphocytes; Forkhead Transcription Factors; Gene Expression; Immune Tolerance; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza A virus; Interleukin-2 Receptor alpha Subunit; Kynurenine; Lymphocyte Activation; Mice; Mice, Knockout; T-Lymphocytes, Regulatory; Tryptophan | 2014 |
Anti-scarring properties of different tryptophan derivatives.
Topics: Administration, Cutaneous; Animals; Cell Movement; Cell Proliferation; Cell Survival; Cicatrix, Hypertrophic; Collagen Type I; Disease Models, Animal; Enzyme Activation; Female; Fibroblasts; Fibronectins; Gene Expression Regulation; Humans; Kynurenine; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Rabbits; Tryptophan; Wound Healing | 2014 |
[Nature Reviews Drug Discovery: editorial article of neuroscientists from Szeged about kynurenine (IF: 33.078)].
Topics: Animals; Central Nervous System Diseases; Humans; Kynurenine; Tryptophan | 2014 |
Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Case-Control Studies; Depression; Fatigue; Female; Humans; Kynurenine; Male; Middle Aged; Prognosis; Serotonin; Stroke; Tryptophan | 2014 |
Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry.
Topics: Adult; Animals; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kynurenine; Linear Models; Male; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reproducibility of Results; Serotonin; Tryptophan; Young Adult | 2014 |
Relation of kynurenine/tryptophan with immune and inflammatory markers in coronary artery disease.
Topics: Aged; Biomarkers; Chromatography, High Pressure Liquid; Coronary Artery Disease; Enzyme-Linked Immunosorbent Assay; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Peroxidase; Spectrophotometry, Ultraviolet; Tryptophan | 2014 |
Aberrant tryptophan metabolism: the unifying biochemical basis for autism spectrum disorders?
Topics: Child Development Disorders, Pervasive; Humans; Kynurenine; Mitochondria; Oxidative Stress; Tryptophan | 2014 |
Cytomegalovirus infection impairs immunosuppressive and antimicrobial effector functions of human multipotent mesenchymal stromal cells.
Topics: Cell Proliferation; Cells, Cultured; Cytokines; Cytomegalovirus; Cytomegalovirus Infections; Hematopoietic Stem Cell Transplantation; Host-Pathogen Interactions; Humans; Hybridomas; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mesenchymal Stem Cells; Staphylococcus aureus; T-Lymphocytes; Tryptophan; Viral Load | 2014 |
Evidence for increased catabolism of vitamin B-6 during systemic inflammation.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Dietary Supplements; Female; Humans; Inflammation; Kynurenine; Linear Models; Longitudinal Studies; Male; Middle Aged; Neopterin; Norway; Oxidative Stress; Pyridoxal; Pyridoxal Phosphate; Pyridoxic Acid; ROC Curve; Tryptophan; Vitamin B 6 | 2014 |
Serum kynurenine/tryptophan ratio is not a potential marker for detecting prostate cancer.
Topics: Aged; Biomarkers; Case-Control Studies; Humans; Kynurenine; Male; Middle Aged; Prostatic Neoplasms; Tryptophan | 2014 |
The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cognition; Disease Models, Animal; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuropsychological Tests; Tryptophan | 2014 |
Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Humans; Immune System; Inflammation; Inflammation Mediators; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Netherlands; Proteolysis; Tryptophan; Young Adult | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan | 2014 |
Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity.
Topics: Animals; Carcinoma, Lewis Lung; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Genetic Therapy; Genetic Vectors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kidney; Kynurenine; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Plasmids; Spleen; Tryptophan; Tumor Cells, Cultured | 2014 |
Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection.
Topics: Adult; CD4-Positive T-Lymphocytes; CD40 Ligand; Female; HIV Infections; Humans; Immune Tolerance; Immunosuppressive Agents; Kynurenine; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; T-Lymphocytes, Regulatory; Tryptophan; Young Adult | 2014 |
B7 costimulation and intracellular indoleamine 2,3-dioxygenase expression in umbilical cord blood and adult peripheral blood.
Topics: Adult; B7 Antigens; CD28 Antigens; CTLA-4 Antigen; Fetal Blood; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Kynurenic Acid; Kynurenine; Monocytes; Primary Cell Culture; Programmed Cell Death 1 Receptor; Signal Transduction; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tryptophan | 2014 |
Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.
Topics: Animals; Antigens, Ly; Apoptosis; CD11b Antigen; Cecum; Clostridioides difficile; Enterocolitis, Pseudomembranous; Flow Cytometry; Host-Pathogen Interactions; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Models, Immunological; Neutrophils; Tryptophan | 2014 |
Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores.
Topics: 5-Hydroxytryptophan; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Color; Hot Temperature; Kynurenine; Mass Spectrometry; Methionine; Oxidation-Reduction; Peptide Mapping; Spectrophotometry, Ultraviolet; Tryptophan; Ultraviolet Rays | 2014 |
Interferon-γ-induced inflammatory markers and the risk of cancer: the Hordaland Health Study.
Topics: Adult; Aged; Biomarkers, Tumor; C-Reactive Protein; Female; Follow-Up Studies; Humans; Inflammation; Interferon-gamma; Kaplan-Meier Estimate; Kynurenine; Male; Middle Aged; Neoplasms; Neopterin; Proportional Hazards Models; Prospective Studies; Risk Factors; Tryptophan | 2014 |
Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway.
Topics: Animals; Cerebellum; Dendrites; Doublecortin Protein; Embryonic Development; Female; Gene Expression Regulation; Hippocampus; Kynurenine; Kynurenine 3-Monooxygenase; Neocortex; Nerve Tissue Proteins; Neurogenesis; Neuronal Plasticity; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sulfonamides; Synaptic Transmission; Thiazoles; Tryptophan | 2014 |
Inhibition of indoleamine 2,3-dioxygenase by stereoisomers of 1-methyl tryptophan in an experimental graft-versus-tumor model.
Topics: Allografts; Animals; Bone Marrow Transplantation; Cell Line, Tumor; Cytotoxicity, Immunologic; Drug Evaluation, Preclinical; Enzyme Induction; Graft vs Tumor Effect; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocyte Transfusion; Lymph Nodes; Lymphocyte Culture Test, Mixed; Mastocytoma; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Radiation Chimera; Spleen; Stereoisomerism; Time Factors; Transplantation Chimera; Tryptophan | 2014 |
Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patients.
Topics: Adult; Anti-Retroviral Agents; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharide Receptors; Male; Tryptophan | 2014 |
[A study of IL-1Β and IDO gene polymorphisms in patients with schizophrenia].
Topics: Adult; Alleles; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-1beta; Kynurenine; Male; Metabolic Networks and Pathways; Minisatellite Repeats; Polymorphism, Genetic; Schizophrenia; Tryptophan; Young Adult | 2014 |
Tryptophan: 'essential' for the pathogenesis of irritable bowel syndrome?
Topics: Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Irritable Bowel Syndrome; Kynurenine; Oxidative Stress; Tryptophan | 2014 |
A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Topics: Animals; Arthritis, Experimental; Biomarkers; Body Weight; Chromatography, Liquid; Joints; Kynurenine; Male; Metabolome; Metabolomics; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan | 2014 |
Simultaneous determination of plasma creatinine, uric acid, kynurenine and tryptophan by high-performance liquid chromatography: method validation and in application to the assessment of renal function.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Female; Humans; Hypertension; Kidney Function Tests; Kynurenine; Limit of Detection; Male; Middle Aged; Renal Insufficiency, Chronic; Tryptophan; Uric Acid | 2015 |
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan | 2015 |
Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest.
Topics: 3-Hydroxyanthranilic Acid; Aged; Arterial Pressure; Cardiopulmonary Resuscitation; Chromatography, Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Logistic Models; Male; Mass Spectrometry; Middle Aged; Out-of-Hospital Cardiac Arrest; Prognosis; Prospective Studies; Shock, Cardiogenic; Tryptophan | 2014 |
Serum interleukin-6 is a predictive biomarker for ketamine's antidepressant effect in treatment-resistant patients with major depression.
Topics: Antidepressive Agents; Biomarkers, Pharmacological; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Humans; Inpatients; Interleukin-1beta; Interleukin-6; Ketamine; Kynurenine; Psychiatric Status Rating Scales; Treatment Outcome; Tryptophan; Tumor Necrosis Factor-alpha | 2015 |
Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-γ-mediated immune activation in the community-based Hordaland Health Study.
Topics: Aged; Biomarkers; Cohort Studies; Diet; Female; Humans; Immunity; Interferon-gamma; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutritional Status; Pyridoxal Phosphate; Riboflavin; Surveys and Questionnaires; Tryptophan; Vitamin B 6 | 2014 |
The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis.
Topics: Animals; Cell Differentiation; Female; Humans; Kynurenine; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoporosis; Tryptophan | 2015 |
Clinical significance of tryptophan metabolism in the nontumoral hemisphere in patients with malignant glioma.
Topics: Adult; Aged; Brain; Brain Neoplasms; Female; Glioma; Humans; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Prognosis; Proportional Hazards Models; Serotonin; Tryptophan | 2014 |
B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women.
Topics: Adult; B7 Antigens; CD28 Antigens; CD4 Lymphocyte Count; CTLA-4 Antigen; Female; Flow Cytometry; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Monocytes; Pregnancy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tryptophan | 2014 |
Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Brain; Corticosterone; Cytokines; Eating; Illness Behavior; Kynurenine; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nod1 Signaling Adaptor Protein; Nod2 Signaling Adaptor Protein; Oligopeptides; Proto-Oncogene Proteins c-fos; RNA, Messenger; Toll-Like Receptor 4; Tryptophan | 2015 |
Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Gene Expression; Hippocampus; Imipramine; Kynurenine; Lipopolysaccharides; Male; Pentoxifylline; Rats; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha | 2014 |
LC-MS-based urinary metabolite signatures in idiopathic Parkinson's disease.
Topics: alpha-Synuclein; Animals; Biomarkers; Chromatography, Liquid; Drosophila melanogaster; Fatty Acids; Histidine; Humans; Kynurenine; Mass Spectrometry; Metabolomics; Nucleotides; Parkinson Disease; Phenotype; Phenylalanine; Steroids; Tryptophan; Tyrosine | 2015 |
The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
Topics: 3-Hydroxyanthranilic Acid; Amino Acid Metabolism, Inborn Errors; Animals; Diet; Hydrolases; Kynurenine; Male; Rats, Wistar; Tryptophan; Weight Gain | 2014 |
[Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases].
Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Tryptophan | 2014 |
Tryptophan catabolism is unaffected in chronic granulomatous disease.
Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan | 2014 |
Romani & Puccetti reply.
Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan | 2014 |
Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis.
Topics: Animals; Anti-Bacterial Agents; Hydroxyquinolines; Intestinal Mucosa; Intestines; Iron Chelating Agents; Kynurenine; Larva; Spodoptera; Tryptophan | 2015 |
Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR).
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Kynurenine; Ligands; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis; Polychlorinated Dibenzodioxins; Protein Binding; Protein Structure, Tertiary; Receptors, Aryl Hydrocarbon; Substrate Specificity; Transcriptome; Tryptophan | 2014 |
Kinetics of glycoxidation of bovine serum albumin by glucose, fructose and ribose and its prevention by food components.
Topics: Advanced Oxidation Protein Products; Animals; Cattle; Coumaric Acids; Fructosamine; Fructose; Glucose; Glycated Serum Albumin; Glycation End Products, Advanced; Kinetics; Kynurenine; Polyphenols; Pyridoxine; Ribose; Serum Albumin; Serum Albumin, Bovine; Tryptophan; Tyrosine | 2014 |
Involvement of the kynurenine pathway in human glioma pathophysiology.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Biosynthetic Pathways; Brain Neoplasms; Carboxy-Lyases; CD11b Antigen; Cells, Cultured; Chromatography, High Pressure Liquid; Disaccharides; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Glucuronates; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2014 |
Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cytokines; Down-Regulation; Drugs, Chinese Herbal; Fluoxetine; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Motor Activity; Rats; Serotonin; Tryptophan; Up-Regulation | 2015 |
Interferon-γ induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells.
Topics: Amino Acid Transport Systems; Animals; Biological Transport; Cell Line; Colon; Dendritic Cells; Epithelial Cells; Feedback, Physiological; Gene Expression Profiling; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kinetics; Kynurenine; Mice; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Tryptophan | 2015 |
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.
Topics: Adult; Astrocytes; Cells, Cultured; Cerebral Cortex; Chronic Disease; Female; Humans; Interleukin-6; Interleukin-8; Kynurenic Acid; Kynurenine; Male; Middle Aged; Schizophrenia; Tryptophan; Young Adult | 2015 |
Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC.
Topics: Acyclic Monoterpenes; Bicyclic Monoterpenes; Cells, Cultured; Cyclohexenes; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lavandula; Leukocytes, Mononuclear; Limonene; Monoterpenes; Neopterin; Oils, Volatile; Phytohemagglutinins; Plant Extracts; Plant Oils; Terpenes; Tryptophan | 2014 |
The tryptophan kynurenine pathway, neopterin and IL-6 during vulvectomy and abdominal hysterectomy.
Topics: Adult; Aged; Biomarkers; Female; Humans; Hysterectomy; Inflammation; Interleukin-6; Kynurenine; Middle Aged; Neopterin; Prospective Studies; Tryptophan; Vulva | 2014 |
Etiological classification of depression based on the enzymes of tryptophan metabolism.
Topics: Antidepressive Agents; Brain; Depressive Disorder; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Pituitary-Adrenal System; Serotonin; Stress, Psychological; Suicide; Tryptophan; Tryptophan Hydroxylase | 2014 |
IDO1 and IDO2 non-synonymous gene variants: correlation with crohn's disease risk and clinical phenotype.
Topics: Adult; Case-Control Studies; Crohn Disease; Female; Genetic Predisposition to Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Tryptophan | 2014 |
Kynurenic acid is a nutritional cue that enables behavioral plasticity.
Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Cues; Fasting; Feeding Behavior; Interneurons; Kynurenic Acid; Kynurenine; Neurons; Neuropeptides; Receptors, N-Methyl-D-Aspartate; Serotonin; Signal Transduction; Transaminases; Tryptophan | 2015 |
Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.
Topics: Animals; Astrocytes; Biogenic Monoamines; Body Weight; Brain; Disease Models, Animal; Kynurenine; Male; Mental Disorders; Metabolic Networks and Pathways; Metabolome; Microglia; Neuroimmunomodulation; Neurotransmitter Agents; Psychopathology; Rats; Tryptophan | 2015 |
Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.
Topics: Adult; Aged; Case-Control Studies; Chemokines; Cytokines; Dendritic Cells; Female; Gene Expression; Gene Expression Regulation; Genotype; Hepacivirus; Hepatitis C; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Leukocyte Count; Male; Middle Aged; Monocytes; RNA, Messenger; Tryptophan; Viral Load; Virus Replication; Young Adult | 2015 |
Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection.
Topics: Adult; Aged; Anti-Retroviral Agents; Biomarkers; Dendritic Cells; HIV Infections; Humans; Intestinal Mucosa; Kynurenine; Longitudinal Studies; Middle Aged; T-Lymphocytes, Regulatory; Tryptophan | 2015 |
Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes.
Topics: Cells, Cultured; Chromatography, Gas; Chromatography, High Pressure Liquid; Fibroblasts; Humans; Immunohistochemistry; Interferon-gamma; Keratinocytes; Kynurenine; L-Lactate Dehydrogenase; NAD; Skin; Tryptophan; Ultraviolet Rays | 2015 |
The relationship of alcohol use disorders and depressive symptoms to tryptophan metabolism: cross-sectional data from a Nepalese alcohol treatment sample.
Topics: Adult; Alcohol-Related Disorders; Biomarkers; Cross-Sectional Studies; Depression; Female; Humans; Kynurenine; Male; Middle Aged; Nepal; Treatment Outcome; Tryptophan; Young Adult | 2015 |
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.
Topics: Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Plasma; Rats; Tryptophan | 2015 |
Serum tryptophan and its metabolites in female dogs undergoing ovariohysterectomy as treatment of pyometra or as elective spay surgery.
Topics: Animals; Dog Diseases; Dogs; Escherichia coli; Female; Hysterectomy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Ovariectomy; Pyometra; Reference Values; Tryptophan; Uterus | 2015 |
Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cytokines; Gene Expression Regulation, Enzymologic; Glucose; Hydrogen Peroxide; Indoleamine-Pyrrole 2,3,-Dioxygenase; Insulin; Insulin Secretion; Interferon-gamma; Interleukin-1beta; Islets of Langerhans; Kynurenine; Kynurenine 3-Monooxygenase; Male; Metabolic Networks and Pathways; Oxidants; Palmitates; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tryptophan | 2015 |
Catalytic activity of human indoleamine 2,3-dioxygenase (hIDO1) at low oxygen.
Topics: Binding Sites; Carbolines; Catalysis; Escherichia coli; Harmine; Humans; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxygen; Protein Binding; Substrate Specificity; Tryptophan | 2015 |
Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice, Knockout; Tryptophan; Tunica Media; Vascular Cell Adhesion Molecule-1 | 2015 |
The impact of electroconvulsive therapy on the tryptophan-kynurenine metabolic pathway.
Topics: Adult; Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan; Young Adult | 2015 |
Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers.
Topics: Adolescent; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Interview, Psychological; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Signal Transduction; Treatment Outcome; Tryptophan; Young Adult | 2015 |
Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
Topics: Animals; Anti-Retroviral Agents; Brain; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Kynurenine; Macaca; Polymerase Chain Reaction; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Tryptophan | 2015 |
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Disease Progression; Female; Human T-lymphotropic virus 1; Humans; Kynurenine; Leukemia-Lymphoma, Adult T-Cell; Lymph Nodes; Male; Middle Aged; Prognosis; Tryptophan | 2015 |
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Arginine; Biomarkers; Dietary Supplements; Female; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Life Style; Male; Methionine; ortho-Aminobenzoates; Pyridoxal Phosphate; Sex Factors; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Xanthurenates; Young Adult | 2015 |
Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer.
Topics: Antibodies, Bacterial; Biomarkers, Tumor; Case-Control Studies; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Helicobacter Infections; Helicobacter pylori; Humans; Immunoglobulin G; Kynurenine; Male; Middle Aged; Neopterin; Prospective Studies; Tryptophan; Tumor Escape | 2015 |
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder.
Topics: Adolescent; Anhedonia; Biomarkers; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Suicide; Suicide, Attempted; Tryptophan | 2015 |
Type I interferon-mediated skewing of the serotonin synthesis is associated with severe disease in systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear; Blood Platelets; Case-Control Studies; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Type I; Kidney; Kynurenine; Lupus Erythematosus, Systemic; Male; Middle Aged; Phenotype; Serotonin; Severity of Illness Index; Tryptophan | 2015 |
Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.
Topics: Animals; Brain; Illness Behavior; Immunity, Innate; Inflammation; Interferon Type I; Interleukin-1beta; Interleukin-6; Kynurenine; Mice; Mice, Knockout; Motor Activity; Poly I-C; Receptors, Interferon; Tryptophan; Tumor Necrosis Factor-alpha | 2015 |
Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine.
Topics: Amines; Fluorescent Dyes; Kynurenine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Tryptophan | 2015 |
Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis.
Topics: Acute-Phase Reaction; Adult; Aged; C-Reactive Protein; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kwashiorkor; Kynurenine; Middle Aged; Niacin; Niacinamide; Pellagra; Skin; Skin Diseases; Tryptophan | 2015 |
Initial O₂ Insertion Step of the Tryptophan Dioxygenase Reaction Proposed by a Heme-Modification Study.
Topics: Acetylation; Animals; Bacterial Proteins; Biocatalysis; Camphor 5-Monooxygenase; Carbon Dioxide; Delftia acidovorans; Deuteroporphyrins; Heme; Kynurenine; Ligands; Mesoporphyrins; Models, Molecular; Myoglobin; Oxidation-Reduction; Oxygen; Tryptophan; Tryptophan Oxygenase | 2015 |
What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?
Topics: Animals; Humans; Kynurenine; Nervous System Diseases; Signal Transduction; Tryptophan | 2015 |
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Case-Control Studies; Female; Glasgow Outcome Scale; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neurotoxins; Prognosis; Quinolinic Acid; RNA, Messenger; Signal Transduction; Tryptophan; Young Adult | 2015 |
[The immunological characteristics of tonsil mesenchymal stem cells].
Topics: Cell Proliferation; Cells, Cultured; Child; Coculture Techniques; Flow Cytometry; Humans; Immunosuppression Therapy; Kynurenine; Leukocytes, Mononuclear; Lymphocyte Culture Test, Mixed; Mesenchymal Stem Cells; Palatine Tonsil; Tryptophan | 2015 |
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Metformin; Middle Aged; Prediabetic State; Pyridoxal Phosphate; Stress, Physiological; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2015 |
Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Child; Female; Glioma; Humans; Kynurenine; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasm Grading; Positron-Emission Tomography; Signal Transduction; Tryptophan; Young Adult | 2015 |
The Kynurenine Pathway of Tryptophan Catabolism and AIDS-Associated Kaposi Sarcoma in Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Female; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Malaria; Male; RNA, Viral; Sarcoma, Kaposi; Tryptophan; Tuberculosis; Viral Load | 2015 |
Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.
Topics: Adult; Disease Progression; Female; Humans; Kynurenine; Male; Middle Aged; Multiple Sclerosis; Tryptophan | 2016 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary Supplements; Female; Glycine; Homocysteine; Humans; Kynurenine; Leucine; Methionine; Methylamines; Multivariate Analysis; Pyridoxal Phosphate; Pyridoxine; Serine; Tryptophan; Vitamin B 6 Deficiency; Young Adult | 2015 |
Elevation of Kynurenine Metabolites in Rat Liver and Serum: A Potential Additional Mechanism of the Alcohol Aversive and Anti-cancer Effects of Disulfiram?
Topics: 3-Hydroxyanthranilic Acid; Alcohol Deterrents; Animals; Chromatography, High Pressure Liquid; Disulfiram; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Rats; Rats, Wistar; Transaminases; Tryptophan | 2016 |
The role of branched chain amino acid and tryptophan metabolism in rat's behavioral diversity: Intertwined peripheral and brain effects.
Topics: Amino Acids, Branched-Chain; Animals; Anxiety; Blood Glucose; Disease Models, Animal; Exploratory Behavior; Insulin; Kynurenine; Large Neutral Amino Acid-Transporter 1; Male; Maze Learning; Plicamycin; Prefrontal Cortex; Protein Synthesis Inhibitors; Random Allocation; Rats, Wistar; RNA, Messenger; Serotonin; Stress, Psychological; Tryptophan | 2015 |
The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy.
Topics: Adult; Aged; Biomarkers, Tumor; Female; Glioblastoma; Humans; Immunotherapy; Kynurenine; Male; Middle Aged; Prognosis; Treatment Outcome; Tryptophan | 2015 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Cross-Sectional Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gas Chromatography-Mass Spectrometry; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-6; Kynurenine; Male; Middle Aged; Neopterin; Niacinamide; Pentosyltransferases; Poverty; Quinolinic Acid; South Africa; Tryptophan | 2015 |
Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipocytes; Adipokines; Adipose Tissue; Adult; Amino Acids; Amino Acids, Branched-Chain; Blood Glucose; Blotting, Western; Body Fat Distribution; Cardiovascular Diseases; Cell Size; Cholesterol, HDL; Cholesterol, LDL; Dyslipidemias; Female; Gene Expression Profiling; Humans; Insulin Resistance; Intra-Abdominal Fat; Kynurenine; Metabolomics; Middle Aged; Obesity; Overweight; Risk Factors; RNA, Messenger; Subcutaneous Fat; Thinness; Triglycerides; Tryptophan | 2015 |
Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Kynurenine; Phenylalanine; Rats; Rats, Inbred SHR; Rats, Transgenic; Tandem Mass Spectrometry; Tauopathies; Tryptophan; Tyrosine | 2016 |
Immunomodulatory metabolites released by the frog-killing fungus Batrachochytrium dendrobatidis.
Topics: Adenosine; Animals; Apoptosis; Cell Survival; Chytridiomycota; Drug Synergism; Host-Pathogen Interactions; Humans; Jurkat Cells; Kynurenine; Lymphocytes; Mycoses; Skin; Thionucleosides; Tryptophan; Xenopus laevis | 2015 |
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Inflammation; Insulin; Kynurenine; Male; Middle Aged; Tryptophan | 2016 |
Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children.
Topics: Alleles; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Food Hypersensitivity; Gene Expression; Gene Frequency; Genotype; Humans; Immunoglobulin E; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant; Kynurenine; Male; Phenotype; Polymorphism, Single Nucleotide; Prognosis; Tryptophan | 2016 |
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.
Topics: Adult; Depression, Postpartum; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Postpartum Period; Psychotic Disorders; Puerperal Disorders; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2016 |
Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.
Topics: Animals; Antimalarials; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Crystallography, X-Ray; Erythrocytes; Escherichia coli; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Malaria; Mice; Mutagenesis, Site-Directed; Plasmodium berghei; Plasmodium falciparum; Quinolizines; Recombinant Proteins; Structure-Activity Relationship; Tryptophan | 2016 |
Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up.
Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; Gene Expression Regulation; HIV Infections; HIV-1; Humans; Interferon-gamma; Kynurenine; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; T-Lymphocyte Subsets; Transforming Growth Factor beta; Tryptophan | 2015 |
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Animals; Biomarkers; Body Mass Index; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Energy Intake; Fatty Acids, Omega-3; Female; Fishes; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutrition Assessment; ortho-Aminobenzoates; Seafood; Triglycerides; Tryptophan; Xanthurenates | 2017 |
Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy.
Topics: Animals; Cecum; Cognitive Dysfunction; Disease Models, Animal; Enzyme Activation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred C57BL; Sepsis; Sepsis-Associated Encephalopathy; Tryptophan | 2016 |
Substrate Oxidation by Indoleamine 2,3-Dioxygenase: EVIDENCE FOR A COMMON REACTION MECHANISM.
Topics: Catalysis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxidation-Reduction; Oxygen; Substrate Specificity; Tryptophan | 2015 |
(13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Antidepressive Agents; Area Under Curve; Breath Tests; Carbon Dioxide; Carbon Isotopes; Depressive Disorder, Major; Exhalation; Female; Humans; Kynurenine; Male; Metabolic Clearance Rate; Metabolic Networks and Pathways; Middle Aged; Regression Analysis; Tryptophan | 2015 |
Fast and sensitive HPLC method for the determination of neopterin, kynurenine and tryptophan in amniotic fluid, malignant effusions and wound exudates.
Topics: Amniotic Fluid; Chromatography, High Pressure Liquid; Exudates and Transudates; Humans; Kynurenine; Neopterin; Pleural Effusion, Malignant; Spectrophotometry, Ultraviolet; Tryptophan; Wound Healing | 2015 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan | 2016 |
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay.
Topics: Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Growth Inhibitors; Humans; Interferon-gamma; Interleukin-6; Kynurenine; Melatonin; Milk, Human; Neuroglia; ortho-Aminobenzoates; Oxygen Radical Absorbance Capacity; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2016 |
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.
Topics: Animals; Antineoplastic Agents; Biological Availability; Drug Design; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tryptophan; Xenograft Model Antitumor Assays | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult | 2016 |
Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Cytokines; Depression; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluoxetine; Hippocampus; Ibuprofen; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Minocycline; Molecular Targeted Therapy; Motor Activity; Norepinephrine; Rats, Wistar; Serotonin; Swimming; Tryptophan; Weight Gain | 2016 |
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Citalopram; Fear; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha | 2016 |
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; Exercise Test; Female; Flow Cytometry; Humans; Hypertension, Pulmonary; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Prospective Studies; ROC Curve; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan | 2016 |
Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction.
Topics: Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenine; Male; Molecular Imaging; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tryptophan | 2016 |
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis.
Topics: Depression; Depressive Disorder, Major; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Mast Cells; Mastocytosis; Middle Aged; Psychiatric Status Rating Scales; Serotonin; Stress, Psychological; Tryptophan | 2016 |
Targeting tryptophan and tyrosine metabolism by liquid chromatography tandem mass spectrometry.
Topics: Adult; Aged; Aggression; Animals; Chromatography, Liquid; Disruptive, Impulse Control, and Conduct Disorders; Female; Genetic Diseases, X-Linked; Healthy Volunteers; Humans; Intellectual Disability; Kynurenic Acid; Kynurenine; Male; Mice; Middle Aged; Monoamine Oxidase; Prefrontal Cortex; Serotonin; Tandem Mass Spectrometry; Tryptophan; Tyrosine; Young Adult | 2016 |
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study.
Topics: Aged; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Kynurenine; Longitudinal Studies; Male; Middle Aged; Mortality; Neopterin; Norway; Tryptophan | 2016 |
Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.
Topics: Biomarkers; Case-Control Studies; Digestive System; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mastocytosis; Tryptophan | 2016 |
Determination of l-tryptophan and l-kynurenine derivatized with (R)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole by LC-MS/MS on a triazole-bonded column and their quantification in human serum.
Topics: Chromatography, High Pressure Liquid; Female; Humans; Isothiocyanates; Kynurenine; Limit of Detection; Male; Oxadiazoles; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles; Tryptophan | 2016 |
Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients.
Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytokines; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diagnostic and Statistical Manual of Mental Disorders; Electroconvulsive Therapy; Female; Humans; Interleukin-6; Kynurenine; Luminescence; Male; Metabolic Networks and Pathways; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Tryptophan; Young Adult | 2016 |
Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation.
Topics: Astrocytes; Biomarkers, Tumor; Carcinogenesis; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Glioblastoma; Humans; Kynurenine; Mass Spectrometry; Metabolomics; Methionine; Oncogenes; Purine-Nucleoside Phosphorylase; Tryptophan; Tumor Cells, Cultured | 2016 |
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.
Topics: Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Injections, Intraventricular; Kynurenine; Memory Disorders; Mice; Nerve Growth Factors; Peptide Fragments; Prefrontal Cortex; Recognition, Psychology; Tryptophan | 2016 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2015 |
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma.
Topics: Biomarkers, Tumor; Biopterins; Carcinoma; Case-Control Studies; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphatic Metastasis; Lymphatic System; Male; Middle Aged; Neoplasm Invasiveness; Neopterin; Predictive Value of Tests; Tryptophan; Urinalysis | 2016 |
Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
Topics: Adult; Anti-Retroviral Agents; Female; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Male; Metabolism; Plasma; Risk Assessment; Signal Transduction; Survival Analysis; Toll-Like Receptors; Tryptophan; Tumor Necrosis Factor-alpha; Uganda | 2016 |
Analysis of Kynurenine/Tryptophan ratio and expression of IDO1 and 2 mRNA in tumour tissue of cervical cancer patients.
Topics: Adenocarcinoma; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Neoplasm Grading; Neoplasm Staging; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tryptophan; Uterine Cervical Neoplasms | 2016 |
Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression.
Topics: Adult; Aggression; Antisocial Personality Disorder; Biomarkers; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Criminals; Humans; Kynurenine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Prisons; Psychiatric Status Rating Scales; Psychotropic Drugs; ROC Curve; Serotonin; Tryptophan | 2016 |
Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes.
Topics: Adult; Athletes; Biomarkers; Exercise; Fatigue; Female; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Metabolism; Neopterin; Oxygen; Tryptophan; Tyrosine | 2016 |
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates | 2015 |
Tryptophan Metabolism and White Matter Integrity in Schizophrenia.
Topics: Adult; Analysis of Variance; Anisotropy; Diffusion Tensor Imaging; Female; Glutamic Acid; Humans; Kynurenine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Tryptophan; White Matter; Young Adult | 2016 |
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Topics: Aged; Animals; Biosynthetic Pathways; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Female; Glioblastoma; Humans; Kynurenine; Male; Mice; Middle Aged; Molecular Imaging; Neoplasm Transplantation; Positron-Emission Tomography; Tryptophan | 2016 |
Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Transport Systems, Neutral; Animals; Brain; Kynurenic Acid; Kynurenine; Male; Rats, Wistar; Schizophrenia; Tryptophan | 2016 |
The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells.
Topics: Adult; Aged; Cancer Vaccines; Dendritic Cells; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Healthy Volunteers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Lipopolysaccharides; Lymphocyte Activation; Male; Middle Aged; Oximes; Peptides; Phenotype; Sulfonamides; T-Lymphocytes, Cytotoxic; Tryptophan; Young Adult | 2016 |
Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated with Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase.
Topics: Acetylcholine; Adiponectin; Animals; Body Weight; Bone Marrow Transplantation; Cytokines; Disease Models, Animal; Female; Graft vs Host Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mesenteric Arteries; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Transplantation, Homologous; Tryptophan; Whole-Body Irradiation | 2016 |
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan | 2016 |
The role of tryptophan degradation in the association between inflammatory markers and depressive symptoms in chronic dialysis patients.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Depression; Female; Glomerulonephritis; Humans; Incidence; Interleukin-10; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Middle Aged; Prospective Studies; Renal Dialysis; Tryptophan; Tumor Necrosis Factor-alpha | 2017 |
Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring.
Topics: Adult; Asthma; Child; Drug Prescriptions; Female; Humans; Interferon-gamma; Kynurenine; Neopterin; Norway; Pregnancy; Tryptophan | 2016 |
EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway.
Topics: Autocrine Communication; Cell Line; Humans; Kynurenine; Oncogene Proteins, Fusion; Proto-Oncogene Protein c-fli-1; Receptors, Aryl Hydrocarbon; RNA-Binding Protein EWS; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2016 |
Inflammasome Activation in Major Depressive Disorder: A Pivotal Linkage Between Psychological Stress, Purinergic Signaling, and the Kynurenine Pathway.
Topics: Depressive Disorder, Major; Humans; Inflammasomes; Kynurenine; Stress, Psychological; Tryptophan | 2016 |
Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.
Topics: Animals; Behavior, Animal; Brain; Circadian Rhythm; Cognition; Dopamine; Exploratory Behavior; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Learning; Locomotion; Memory, Short-Term; Mice; Mice, Inbred C57BL; Serotonin; Tryptophan; Tryptophan Oxygenase | 2016 |
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan | 2016 |
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis.
Topics: Adult; Bariatric Surgery; C-Reactive Protein; Diabetes Mellitus; Female; Glucose; Homeostasis; Humans; Kynurenine; Metabolome; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates | 2016 |
Tryptophan and kynurenines: continuing to court controversy.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxidation-Reduction; Tryptophan | 2016 |
Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.
Topics: Adult; Female; Gliadin; Humans; Immunoglobulin G; Kynurenine; Male; Middle Aged; Schizophrenia; Tryptophan | 2016 |
Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues.
Topics: Animals; Dehydration; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Liver; Male; Rats; Rats, Wistar; Tryptophan; Tryptophan Oxygenase | 2017 |
Metabolomic Analysis of Gastric Cancer Progression within the Correa's Cascade Using Ultraperformance Liquid Chromatography-Mass Spectrometry.
Topics: Adenocarcinoma; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Disease Progression; Female; Gastritis; Glutamine; Helicobacter Infections; Helicobacter pylori; Humans; Kynurenine; Male; Mass Spectrometry; Metabolomics; Middle Aged; Plasma; Precancerous Conditions; Stomach Neoplasms; Tryptophan | 2016 |
Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Host-Pathogen Interactions; Immunity, Innate; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Mice; Murinae; ortho-Aminobenzoates; Pseudomonas aeruginosa; Pseudomonas Infections; Transaminases; Tryptophan | 2016 |
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.
Topics: Animals; Cerebellum; Chromatography, Liquid; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Hippocampus; Kynurenic Acid; Kynurenine; Prefrontal Cortex; Rats; Tryptophan | 2017 |
Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.
Topics: Animals; Behavior, Animal; Depression; Enzyme Induction; Female; Frontal Lobe; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Interferon-gamma; Kynurenine; Male; Metabolome; Mice, Inbred C57BL; Middle Aged; Serotonin; Swimming; Tryptophan | 2016 |
Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance.
Topics: Animals; Bone Marrow Cells; Dendritic Cells; Genes, MHC Class II; Histoplasma; Histoplasmosis; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Mice; Phenotype; Programmed Cell Death 1 Ligand 2 Protein; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan; Zinc | 2016 |
Serum indoleamine 2,3 dioxygenase and tryptophan and kynurenine ratio using the UPLC-MS/MS method, in patients undergoing peritoneal dialysis, hemodialysis, and kidney transplantation.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine; Male; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Tandem Mass Spectrometry; Tryptophan; Turkey | 2016 |
Altered tryptophan metabolism in human meningioma.
Topics: Analysis of Variance; Autopsy; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyindoleacetic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Meningeal Neoplasms; Meningioma; Nitric Oxide; Nitric Oxide Synthase Type II; RNA, Messenger; Serotonin; Tryptophan | 2016 |
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammation; Interleukin-10; Kynurenine; Linear Models; Male; Neopterin; ortho-Aminobenzoates; Pyridoxal Phosphate; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Young Adult | 2016 |
Advanced age negatively impacts survival in an experimental brain tumor model.
Topics: Aging; Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred C57BL; Survival Analysis; Tryptophan | 2016 |
Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Freund's Adjuvant; Hippocampus; Hyperalgesia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-1beta; Interleukin-6; Ketamine; Kynurenine; Male; Nociception; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan | 2016 |
Plasma Tryptophan and the Kynurenine-Tryptophan Ratio are Associated with the Acquisition of Statural Growth Deficits and Oral Vaccine Underperformance in Populations with Environmental Enteropathy.
Topics: Anthropometry; Antibodies; Antibodies, Viral; Child Development; Child, Preschool; Citrulline; Cohort Studies; Cytokines; Enteritis; Female; Growth Disorders; Humans; Infant; Inflammation; Kynurenine; Linear Models; Male; Peru; Poliovirus Vaccine, Oral; Tanzania; Tetanus Toxoid; Tryptophan | 2016 |
LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Humans; Kynurenine; Mice, Inbred C57BL; Neopterin; ortho-Aminobenzoates; Quinolinic Acid; Signal Transduction; Tandem Mass Spectrometry; Tryptophan | 2016 |
Resveratrol intake enhances indoleamine-2,3-dioxygenase activity in humans.
Topics: Administration, Oral; Adult; Biomarkers; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Neopterin; Pilot Projects; Resveratrol; Stilbenes; Tryptophan; Young Adult | 2016 |
Influence of core body temperature on Tryptophan metabolism, kynurenines, and estimated IDO activity in critically ill patients receiving target temperature management following cardiac arrest.
Topics: Aged; Body Temperature; Coma; Critical Illness; Female; Germany; Heart Arrest; Humans; Hypothermia, Induced; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neurologic Examination; Outcome Assessment, Health Care; Prognosis; Recovery of Function; Statistics as Topic; Systemic Inflammatory Response Syndrome; Tryptophan | 2016 |
A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy.
Topics: Antidepressive Agents; Case-Control Studies; Chromatography, High Pressure Liquid; Depression; Drug Monitoring; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tryptophan | 2017 |
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
Topics: Flagellin; Gene Expression Regulation; Humans; Hydrolysis; Imidazoles; Kynurenic Acid; Kynurenine; Lipopeptides; Lipopolysaccharides; Listeria monocytogenes; Monocytes; Poly I-C; Primary Cell Culture; Protein Isoforms; Quinolinic Acid; Signal Transduction; Toll-Like Receptors; Tryptophan | 2016 |
Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Caspases; Cytokines; Female; Flavonoids; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neurochemistry; Receptors, Corticotropin-Releasing Hormone; Serotonin; Stress, Psychological; Tryptophan | 2016 |
Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.
Topics: Catalysis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Hypersensitivity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Ligands; Lymphocyte Activation; T-Lymphocytes; Toll-Like Receptor 3; Toll-Like Receptor 4; Tryptophan | 2016 |
Kynurenine pathway and white matter microstructure in bipolar disorder.
Topics: Adult; Bipolar Disorder; Diffusion Tensor Imaging; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Serotonin; Signal Transduction; Tryptophan; White Matter; Young Adult | 2018 |
Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2
Topics: Animals; Autism Spectrum Disorder; Brain; Chromatography, Liquid; Female; Kynurenic Acid; Kynurenine; Methyl-CpG-Binding Protein 2; ortho-Aminobenzoates; Pregnancy; Rats, Wistar; Tandem Mass Spectrometry; Tryptophan | 2016 |
Inflammatory, endocrine and metabolic correlates of fatigue in obese children.
Topics: Adolescent; Anhedonia; Apathy; Body Mass Index; C-Reactive Protein; Child; Fatigue; Female; Humans; Inflammation; Insulin; Insulin Resistance; Kynurenine; Male; Mental Fatigue; Pediatric Obesity; Tryptophan | 2016 |
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Disease Models, Animal; Exploratory Behavior; Food Preferences; Hippocampus; Imipramine; Kynurenine; Kynurenine 3-Monooxygenase; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Sertraline; Sucrose; Swimming; Tryptophan | 2017 |
Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.
Topics: Animals; Cytokines; Dendritic Cells; Female; Half-Life; Immune Tolerance; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Domains; Signal Transduction; Suppressor of Cytokine Signaling Proteins; Tryptophan; Tyrosine | 2017 |
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
Topics: Catalysis; Crystallography, X-Ray; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxygen; Protein Binding; Protein Structure, Secondary; Tryptophan; Tryptophan Oxygenase | 2016 |
Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Chronic Disease; Cytokines; Depression; Fluoxetine; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Mice, Inbred BALB C; Signal Transduction; Stress, Psychological; Time Factors; Tryptophan | 2016 |
Mass Spectrometry Based Metabolomics Comparison of Liver Grafts from Donors after Circulatory Death (DCD) and Donors after Brain Death (DBD) Used in Human Orthotopic Liver Transplantation.
Topics: Adult; Biomarkers; Brain Death; Cyclotrons; Female; Glucose; Glutathione; Graft Survival; Humans; Kynurenine; Liver; Liver Transplantation; Male; Metabolomics; Middle Aged; Principal Component Analysis; S-Adenosylmethionine; Shock; Spectroscopy, Fourier Transform Infrared; Tissue Donors; Tryptophan; Warm Ischemia | 2016 |
Development of screen-printed tryptophan-kynurenine immunosensor for in vitro assay of kynurenine-mediated immunosuppression effect of cancer cells on activated T-cells.
Topics: Antibodies, Immobilized; Biosensing Techniques; Cell Line, Tumor; Electrodes; Equipment Design; Gold; Humans; Immune Tolerance; Immunoassay; Kynurenine; Lymphocyte Activation; Nanotubes, Carbon; Neoplasms; Potentiometry; T-Lymphocytes; Tryptophan | 2017 |
Regulation of kynurenine biosynthesis during influenza virus infection.
Topics: Animals; Antiviral Agents; Female; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Influenza A Virus, H1N1 Subtype; Interferons; Kynurenine; Lung; Macrophages; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oxazoles; Oximes; Primary Cell Culture; Pyrroles; Sulfonamides; Thiazoles; Transcriptome; Tryptophan; Viral Nonstructural Proteins; Virus Replication | 2017 |
In vitro rescue of genital strains of Chlamydia trachomatis from interferon-γ and tryptophan depletion with indole-positive, but not indole-negative Prevotella spp.
Topics: Chlamydia Infections; Chlamydia trachomatis; Epithelial Cells; Female; HeLa Cells; Hep G2 Cells; Humans; In Vitro Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Interferon-gamma; Kynurenine; Microbiota; Prevotella; RNA, Messenger; Tryptophan; Tryptophan Synthase; Vaginal Diseases | 2016 |
CD4/CD8 Ratio and KT Ratio Predict Yellow Fever Vaccine Immunogenicity in HIV-Infected Patients.
Topics: Adult; Antibodies, Neutralizing; Antibodies, Viral; CD4-CD8 Ratio; Female; HIV Infections; Humans; Immunogenicity, Vaccine; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Prospective Studies; Tryptophan; Viremia; Yellow Fever; Yellow Fever Vaccine; Yellow fever virus | 2016 |
Kynurenine Pathway Activation in Human African Trypanosomiasis.
Topics: Adolescent; Adult; Aged; Biomarkers; Central Nervous System; Female; Humans; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-6; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Retrospective Studies; Transaminases; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Tryptophan; Young Adult | 2017 |
Activation of the tryptophan/serotonin pathway is associated with severity and predicts outcomes in pneumonia: results of a long-term cohort study.
Topics: Aged; Aged, 80 and over; Biomarkers; Cohort Studies; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Patient Admission; Pneumonia; Prognosis; Serotonin; Tryptophan | 2017 |
Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Interleukin-10 Receptor alpha Subunit; Intestinal Mucosa; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Wound Healing | 2017 |
Predictive and prognostic role of serum neopterin and tryptophan breakdown in prostate cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Humans; Kaplan-Meier Estimate; Kynurenine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neopterin; Outcome Assessment, Health Care; Postoperative Period; Predictive Value of Tests; Preoperative Period; Prognosis; Proportional Hazards Models; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; ROC Curve; Tryptophan | 2017 |
5-Hydroxytryptophan, a major product of tryptophan degradation, is essential for optimal replication of human parainfluenza virus.
Topics: 5-Hydroxytryptophan; A549 Cells; Animals; Antiviral Agents; Cell Line, Tumor; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferons; Kynurenine; Macaca mulatta; Parainfluenza Virus 3, Human; Respirovirus Infections; Tryptophan; Virus Replication | 2017 |
Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism.
Topics: Animals; Arylalkylamine N-Acetyltransferase; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; MAP Kinase Kinase 4; Melatonin; Metabolic Networks and Pathways; Nerve Tissue Proteins; Oncogene Protein v-akt; PC12 Cells; Promoter Regions, Genetic; Rats; Serotonin; Tryptophan | 2017 |
Targeting a metabolic pathway to fight the flu.
Topics: Antiviral Agents; Host-Pathogen Interactions; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza, Human; Interferons; Kynurenine; Macrophages; Metabolic Networks and Pathways; Orthomyxoviridae; Transcriptome; Tryptophan | 2017 |
Intracerebroventricular Administration of Streptozotocin as an Experimental Approach to Depression: Evidence for the Involvement of Proinflammatory Cytokines and Indoleamine-2,3-Dioxygenase.
Topics: Animals; Blood Glucose; Cytokines; Depression; Disease Models, Animal; Grooming; Hippocampus; Hydroxyindoleacetic Acid; Immobility Response, Tonic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infusions, Intraventricular; Kynurenine; Male; Mice; Minocycline; Serotonin; Streptozocin; Tryptophan | 2017 |
The activation of the kynurenine pathway in a rat model with renovascular hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypertension, Renovascular; Kynurenine; Male; Metabolic Networks and Pathways; Rats; Rats, Wistar; Tryptophan | 2017 |
The Relationship of Kynurenine and Neopterin Levels and Their Association with a Selection of Other Immune Markers in Chronic Myeloid Leukaemia Patients.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Case-Control Studies; Female; Humans; Interleukin-6; Kynurenine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocyte Count; Linear Models; Male; Middle Aged; Neopterin; Tryptophan; Young Adult | 2016 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2017 |
Relationships between body temperatures and inflammation indicators under physiological and pathophysiological conditions in pigs exposed to systemic lipopolysaccharide and dietary deoxynivalenol.
Topics: Animal Feed; Animals; Biomarkers; Body Temperature; Inflammation; Kynurenine; Lipopolysaccharides; Swine; Trichothecenes; Tryptophan | 2018 |
Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy.
Topics: Adult; Anti-HIV Agents; Biomarkers; Cohort Studies; Female; Fibrin Fibrinogen Degradation Products; HIV Infections; Humans; Interleukin-6; Kynurenine; Lipopolysaccharide Receptors; Male; Multivariate Analysis; Prognosis; Proportional Hazards Models; T-Lymphocytes; Tryptophan; Uganda; Viral Load | 2017 |
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Topics: Animals; Benzoxazoles; Drug Discovery; Enzyme Inhibitors; HEK293 Cells; Humans; Indazoles; Kynurenine; Kynurenine 3-Monooxygenase; Pancreatitis; Rats; Tryptophan | 2017 |
Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma.
Topics: 5-Hydroxytryptophan; Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Disease Progression; Early Diagnosis; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Lymphatic Metastasis; Male; Metabolome; Middle Aged; Prognosis; Serotonin; Tryptophan | 2017 |
Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.
Topics: Adult; Aged; Anxiety; Biomarkers; C-Reactive Protein; Case-Control Studies; Colon; Depression; Female; Gene Expression; Humans; Inflammation; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Matrix Metalloproteinase 9; Middle Aged; Quality of Life; Tryptophan | 2017 |
Tryptophan and Kynurenine Levels and Its Association With Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients.
Topics: Adult; Aged; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Depression; Fatigue; Female; Humans; Kynurenine; Male; Middle Aged; Renal Dialysis; Reproducibility of Results; Sleep; Surveys and Questionnaires; Tryptophan | 2017 |
Simultaneous determination of tryptophan and 8 metabolites in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Equipment Design; Humans; Kynurenine; Limit of Detection; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2017 |
Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.
Topics: Aged; alpha-Tocopherol; Asia; Australia; Biomarkers; Carbon; Cross-Sectional Studies; Dietary Supplements; Female; Humans; Kynurenine; Laboratories; Male; Middle Aged; Scandinavian and Nordic Countries; Tryptophan; United States; Vitamin A; Vitamin B Complex; Vitamin D | 2017 |
Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Calcitonin; Chromatography, Liquid; Disease Progression; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Oxygen; Prognosis; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Risk Factors; Serotonin; Switzerland; Tandem Mass Spectrometry; Time Factors; Tryptophan; Tryptophan Hydroxylase | 2017 |
Peripheral kynurenine/tryptophan ratio is not a reliable marker of systemic indoleamine 2,3-dioxygenase: A lesson drawn from patients on hemodialysis.
Topics: Case-Control Studies; Cross-Sectional Studies; HEK293 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Prospective Studies; Renal Dialysis; Survival Analysis; Tryptophan | 2017 |
Altered placental tryptophan metabolic pathway in human fetal growth restriction.
Topics: Adult; Female; Fetal Blood; Fetal Growth Retardation; Humans; Kynurenine; Metabolic Networks and Pathways; Placenta; Pregnancy; Tryptophan | 2017 |
Comparison of plasma tryptophan-related metabolites in crossbred Piétrain and Duroc pigs.
Topics: Animal Feed; Animals; Diet; Dietary Supplements; Female; Genotype; Ileum; Kynurenine; Male; Niacin; Postprandial Period; Serotonin; Swine; Tryptophan; Weaning | 2017 |
In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Graft vs Host Disease; Humans; Immune Tolerance; In Vitro Techniques; Kynurenine; Mice; Survival Rate; T-Lymphocytes, Regulatory; Tryptophan | 2017 |
Tryptophan breakdown and cognition in bipolar disorder.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Sex Factors; Tryptophan | 2017 |
The tryptophan/kynurenine pathway, systemic inflammation, and long-term outcome after kidney transplantation.
Topics: Adult; Biomarkers; Chromatography, Liquid; Female; Graft Rejection; Graft Survival; Humans; Inflammation; Inflammation Mediators; Kidney Transplantation; Kynurenine; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Tandem Mass Spectrometry; Time Factors; Treatment Outcome; Tryptophan; Vascular Diseases | 2017 |
Tryptophan catabolism and immune activation in primary and chronic HIV infection.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chronic Disease; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Prospective Studies; Tryptophan | 2017 |
Effects of tryptophan, kynurenine and kynurenic acid exerted on human reconstructed corneal epithelium in vitro.
Topics: Antidepressive Agents, Second-Generation; Cell Proliferation; Cell Survival; Epithelial Cells; Epithelium, Corneal; Gene Expression Regulation; Humans; Interleukin-10; Interleukin-6; Kynurenic Acid; Kynurenine; Nitric Oxide; Tissue Culture Techniques; Tryptophan | 2017 |
Microenvironment Tumor Metabolic Interactions Highlighted by qMSI: Application to the Tryptophan-Kynurenine Pathway in Immuno-Oncology.
Topics: Animals; Cell Line, Tumor; Imaging, Three-Dimensional; Kynurenine; Mass Spectrometry; Mice; Neoplasms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tryptophan; Tumor Microenvironment | 2017 |
Possible changes of New-Generation inflammation markers with occupational lead exposure.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Hospitals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lead; Male; Middle Aged; Neopterin; Occupational Exposure; Tryptophan; Turkey | 2017 |
IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYC
Topics: Adult; Autoimmunity; Bacterial Translocation; Biomarkers; Cytokines; Depression, Postpartum; Depressive Disorder, Major; Epitopes; Female; Gram-Negative Bacteria; Humans; Immunoglobulin M; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide; Pregnancy; Tryptophan; Young Adult | 2017 |
Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model.
Topics: Animals; Antineoplastic Agents; Drug Therapy, Combination; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-2; Isoindoles; Kynurenine; Male; Melanoma, Experimental; Mice, Inbred C57BL; Paclitaxel; T-Lymphocytes; Tryptophan; Tumor Burden | 2017 |
The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease.
Topics: Aged; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Kynurenine; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Risk Factors; Tryptophan | 2017 |
SBMLmod: a Python-based web application and web service for efficient data integration and model simulation.
Topics: Cell Line, Tumor; Humans; Internet; Kynurenine; Models, Theoretical; Neoplasms; Serotonin; Tryptophan; User-Computer Interface | 2017 |
Comprehensive analysis of the tryptophan metabolome in urine of patients with acute intermittent porphyria.
Topics: Adult; Biomarkers; Cohort Studies; Female; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; Porphyria, Acute Intermittent; Serotonin; Tryptophan; Young Adult | 2017 |
The association between the hypothalamic pituitary adrenal axis and tryptophan metabolism in persons with recurrent major depressive disorder and healthy controls.
Topics: Adult; Antidepressive Agents; Chromatography, High Pressure Liquid; Depression; Depressive Disorder, Major; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Kynurenine; Male; Middle Aged; Pituitary-Adrenal System; Recurrence; Tandem Mass Spectrometry; Tryptophan | 2017 |
The role of tryptophan metabolism and food craving in the relationship between obesity and bipolar disorder.
Topics: Adult; Bipolar Disorder; Body Mass Index; Craving; Eating; Energy Metabolism; Female; Food; Humans; Kynurenine; Lipid Metabolism; Male; Middle Aged; Neopterin; Nitrites; Obesity; Sex Factors; Tryptophan; Waist-Hip Ratio | 2018 |
Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss.
Topics: Adiposity; Aging; Animals; Body Weight; Bone and Bones; Bone Resorption; Calcification, Physiologic; Cell Differentiation; Diet; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Osteoclasts; Tryptophan; X-Ray Microtomography | 2017 |
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative Stress; Quinolinic Acid; Tryptophan | 2017 |
Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues.
Topics: Bacterial Proteins; Cross-Linking Reagents; Enzyme Assays; Glucosephosphate Dehydrogenase; Kinetics; Kynurenine; Leuconostoc mesenteroides; Light; Oxidation-Reduction; Peroxides; Photochemical Processes; Protein Aggregates; Singlet Oxygen; Solutions; Tryptophan; Tyrosine | 2017 |
Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder.
Topics: Adult; Affect; Biomarkers; Bipolar Disorder; Depression; Female; Humans; Inflammation; Kynurenine; Male; Middle Aged; Neopterin; Outcome Assessment, Health Care; Serotonin; Sleep; Sleep Initiation and Maintenance Disorders; Tryptophan | 2018 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Female; Humans; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Signal Transduction; Statistics, Nonparametric; Tryptophan; Xanthurenates | 2017 |
Tryptophan circuit in fatigue: From blood to brain and cognition.
Topics: Animals; Blood-Brain Barrier; Brain; Cognition; Fatigue; Female; Kynurenine; Maze Learning; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tryptophan | 2017 |
Activation of indoleamine 2, 3- dioxygenase pathway by olanzapine augments antidepressant effects of venlafaxine in mice.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Depression; Depressive Disorder, Treatment-Resistant; Female; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Mice; Olanzapine; Serotonin; Stress, Psychological; Swimming; Tryptophan; Venlafaxine Hydrochloride | 2017 |
Tryptophan and kynurenine determination in human hair by liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Hair; Humans; Kynurenine; Limit of Detection; Linear Models; Reproducibility of Results; Tryptophan | 2017 |
Assessment of tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption.
Topics: Adult; Biomarkers; Breath Tests; Cross-Sectional Studies; Depression; Female; Fructose; Fructose Intolerance; Humans; Kynurenine; Lactase; Lactose Intolerance; Logistic Models; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Tryptophan | 2018 |
Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Pain; Cytokines; Depression; Hydroxyindoleacetic Acid; Hyperalgesia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice, Inbred ICR; Neuralgia; Sciatic Nerve; Serotonin; Stereoisomerism; Tryptophan; Xanthophylls | 2018 |
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution.
Topics: Adult; Antibodies, Viral; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Coinfection; Female; Herpes Simplex; Herpesvirus 1, Human; HIV Infections; Humans; Immune Reconstitution Inflammatory Syndrome; Inflammation; Kynurenine; Male; Metabolic Networks and Pathways; Seroepidemiologic Studies; Tryptophan | 2017 |
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior.
Topics: Amino Acids; Animals; Anxiety; Behavior, Animal; Brain; Dopamine; Fear; Interferon-gamma; Kynurenine; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor; Serotonin; T-Lymphocytes; Tryptophan; Tyrosine | 2017 |
Clinical significance of tryptophan catabolism in Hodgkin lymphoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Hodgkin Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ki-1 Antigen; Kynurenine; Male; Middle Aged; Prognosis; Survival Analysis; Tryptophan; Young Adult | 2018 |
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Mice; Placenta; Pregnancy; Tryptophan | 2017 |
IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.
Topics: Adenocarcinoma; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chemoradiotherapy; Disease Progression; Female; Follow-Up Studies; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Male; Prognosis; Prospective Studies; Survival Rate; Tryptophan | 2018 |
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Topics: Adult; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Neopterin; Obesity; Pregnancy; Pregnancy Complications; Tryptophan | 2018 |
Determination of tryptophan derivatives in kynurenine pathway in fermented foods using liquid chromatography tandem mass spectrometry.
Topics: Beer; Cheese; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cultured Milk Products; Fermented Foods; Kynurenic Acid; Kynurenine; Tandem Mass Spectrometry; Tryptophan; Wine | 2018 |
Effects of high ambient temperature on plasma metabolomic profiles in chicks.
Topics: Amino Acids, Sulfur; Animals; Chickens; Cystathionine; Cysteine; Cystine; Environmental Exposure; Gas Chromatography-Mass Spectrometry; Homocysteine; Hot Temperature; Kynurenine; Molecular Weight; Niacinamide; Oxidative Stress; Quinolinic Acid; Taurine; Tryptophan | 2018 |
Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5-hydroxytryptamine in human plasma by LC-MS/MS and its application to acute myocardial infarction monitoring.
Topics: Case-Control Studies; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Linear Models; Myocardial Infarction; Reproducibility of Results; Sensitivity and Specificity; Serotonin; Tandem Mass Spectrometry; Tryptophan; Xanthurenates | 2018 |
HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway.
Topics: Animals; Depression; Depressive Disorder; Hippocampus; HMGB1 Protein; Hydrolases; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Inbred BALB C; Motor Activity; Pyruvates; Sirtuin 1; Stress, Psychological; Tryptophan | 2018 |
Structure based mimicking of Phthalic acid esters (PAEs) and inhibition of hACMSD, an important enzyme of the tryptophan kynurenine metabolism pathway.
Topics: Binding Sites; Carboxy-Lyases; Esters; Humans; Hydrogen Bonding; Kynurenine; Ligands; Metabolic Networks and Pathways; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Phthalic Acids; Protein Binding; Solvents; Structure-Activity Relationship; Tryptophan | 2018 |
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Locomotion; Male; Neural Cell Adhesion Molecules; Quinolinic Acid; Rats, Sprague-Dawley; Signal Transduction; Tryptophan | 2018 |
Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model.
Topics: Animals; Bile Ducts; Disease Models, Animal; Hepatic Encephalopathy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Ligation; Male; Rats; Rats, Wistar; Signal Transduction; Tryptophan | 2018 |
Kynurenine is correlated with IL-1β in plasma of schizophrenia patients.
Topics: Adult; Female; Humans; Interleukin-1beta; Kynurenine; Male; Schizophrenia; Tryptophan | 2018 |
Toxicity and cardiac effects of acute exposure to tryptophan metabolites on the kynurenine pathway in early developing zebrafish (Danio rerio) embryos.
Topics: Animals; Dose-Response Relationship, Drug; Embryonic Development; Heart Rate; Kynurenine; Signal Transduction; Tryptophan; Zebrafish | 2018 |
A validated liquid chromatography-high resolution-tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Kynurenic Acid; Kynurenine; Limit of Detection; Metabolome; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Glycyrrhizic Acid; HMGB1 Protein; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice, Inbred BALB C; Random Allocation; Stress, Psychological; Tissue Culture Techniques; Tryptophan | 2018 |
Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages.
Topics: Aldose-Ketose Isomerases; Amino Acid Transport Systems; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Gene Expression Profiling; Gene Expression Regulation; Healthy Volunteers; Humans; Inflammation Mediators; Interferon-alpha; Kynurenine; Leukocytes, Mononuclear; Lipopolysaccharides; Macrophages; Tryptophan | 2018 |
Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.
Topics: Adult; Bariatric Surgery; Biomarkers; C-Reactive Protein; Female; Glycated Hemoglobin; Humans; Inflammation; Kynurenine; Male; Middle Aged; Obesity; Tryptophan; Vitamin B Complex | 2018 |
Dysregulation of Tryptophan Catabolism in Metabolic Syndrome.
Topics: Adult; Body Mass Index; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Kynurenine; Male; Metabolic Syndrome; Obesity; Tryptophan; Young Adult | 2018 |
Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.
Topics: Adult; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Disease Progression; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Prospective Studies; Tryptophan | 2018 |
Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals.
Topics: Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Goblet Cells; HT29 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Receptor, Notch1; Receptors, Aryl Hydrocarbon; Transcription Factor HES-1; Tryptophan; Wnt Signaling Pathway | 2018 |
Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study.
Topics: Adult; Biomarkers; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Kynurenine; Lipids; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Tryptophan | 2018 |
Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages.
Topics: Apoptosis; Cell Proliferation; Cell Survival; Fusobacterium Infections; Fusobacterium nucleatum; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-6; Kynurenine; Lymphocytes; Macrophages; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; THP-1 Cells; Tryptophan; Tumor Necrosis Factor-alpha | 2018 |
Increased kynurenine plasma concentrations and kynurenine-tryptophan ratio in mild-to-moderate chronic obstructive pulmonary disease patients.
Topics: Aged; Biomarkers; Case-Control Studies; Female; Humans; Kynurenine; Logistic Models; Male; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Sensitivity and Specificity; Severity of Illness Index; Tryptophan | 2018 |
Immunobiochemical pathways of neopterin formation and tryptophan breakdown via indoleamine 2,3-dioxygenase correlate with circulating tumor cells in ovarian cancer patients- A study of the OVCAD consortium.
Topics: Carcinoma, Ovarian Epithelial; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Middle Aged; Neoplasms, Glandular and Epithelial; Neoplastic Cells, Circulating; Neopterin; Ovarian Neoplasms; Tryptophan | 2018 |
Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism.
Topics: Adult; Case-Control Studies; Critical Illness; Female; Humans; Kynurenine; Male; Metabolomics; Tryptophan; Venous Thromboembolism | 2018 |
Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of
Topics: Cells, Cultured; Diterpenes; Humans; Immunologic Factors; Kynurenine; Lamiaceae; Leukocytes, Mononuclear; Neopterin; Plant Extracts; Plant Roots; Quinones; Tryptophan | 2018 |
Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism.
Topics: Animals; Animals, Genetically Modified; Drosophila melanogaster; Excitatory Amino Acid Antagonists; Eye Color; Gene Expression; Kynurenic Acid; Kynurenine; Mercury Compounds; Microarray Analysis; Pupa; Signal Transduction; Tryptophan | 2018 |
Kynurenine pathway changes in late-life depression.
Topics: Adult; Age Factors; Aged; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan | 2018 |
Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kynurenine; Meningeal Neoplasms; Meningioma; Neoplasm Grading; Receptors, Aryl Hydrocarbon; Tryptophan | 2018 |
Mass spectrometric measurement of urinary kynurenine-to-tryptophan ratio in children with and without urinary tract infection.
Topics: Algorithms; Biomarkers; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant; Kynurenine; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan; Urinary Tract Infections | 2018 |
Impact of a single, short morning bright light exposure on tryptophan pathways and visuo- and sensorimotor performance: a crossover study.
Topics: Adult; Cross-Over Studies; Female; Humans; Kynurenine; Light; Male; Melatonin; Psychomotor Performance; Random Allocation; Tryptophan | 2018 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2017 |
Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Amino Acid Substitution; Humans; Kynurenine; Mutation; Protein Conformation; Sequence Homology; Substrate Specificity; Tryptophan | 2018 |
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Neopterin; Risk Factors; RNA, Ribosomal, 16S; Tryptophan | 2018 |
Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification.
Topics: Biomarkers; Cell Line; Chromatography, High Pressure Liquid; Endothelial Cells; Fatty Acids; gamma-Aminobutyric Acid; Glycocalyx; Human Umbilical Vein Endothelial Cells; Humans; Interferon-gamma; Kynurenine; Lipopolysaccharides; Lysophospholipids; Metabolome; Models, Biological; Nitric Oxide; Permeability; Polysaccharides; Prostaglandin D2; Sepsis; Sphingosine; Survival Analysis; Tryptophan | 2018 |
High Indoleamine 2,3-Dioxygenase Is Correlated With Microvessel Density and Worse Prognosis in Breast Cancer.
Topics: Adult; Aged; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Endoglin; Female; Human Umbilical Vein Endothelial Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Microvessels; Middle Aged; Neovascularization, Pathologic; Prognosis; Tryptophan | 2018 |
Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats.
Topics: Animals; Cognition; Corticosterone; Female; Hippocampus; Kynurenic Acid; Kynurenine; Male; Memory; Rats; Rats, Wistar; Sex Characteristics; Sleep Deprivation; Tryptophan | 2018 |
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan | 2019 |
Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Immunosuppression Therapy; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Mice; Myeloid-Derived Suppressor Cells; Neoplasm Transplantation; Tryptophan; Tumor Microenvironment | 2018 |
Changes in the tryptophan-kynurenine axis in association to therapeutic response in clinically depressed patients undergoing psychiatric rehabilitation.
Topics: Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Combined Modality Therapy; Depression; Female; Humans; Interleukin-6; Kynurenine; Male; Middle Aged; Psychiatric Rehabilitation; Psychiatric Status Rating Scales; Treatment Outcome; Tryptophan | 2018 |
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts.
Topics: Adolescent; C-Reactive Protein; Child; Cohort Studies; Cross-Sectional Studies; Cytokines; Depression; Depressive Disorder; Female; Humans; Inflammation; Interferon-gamma; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha | 2018 |
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.
Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.
Topics: Adolescent; Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Colonoscopy; Female; Gas Chromatography-Mass Spectrometry; Humans; Inflammation; Kynurenine; Logistic Models; Male; Metabolic Networks and Pathways; Middle Aged; Multivariate Analysis; Sensitivity and Specificity; Tryptophan; Young Adult | 2018 |
Simultaneous determination of tryptophan, kynurenine, kynurenic acid and two monoamines in rat plasma by HPLC-ECD/DAD.
Topics: Amino Acids, Essential; Animals; Boron; Chemical Fractionation; Chromatography, High Pressure Liquid; Depression; Diamond; Electrochemical Techniques; Electrodes; Fluorescence; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Limit of Detection; Models, Animal; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serotonin; Tryptophan | 2018 |
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.
Topics: Aged; Animals; Brain; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Huntingtin Protein; Huntington Disease; Kynurenine; Kynurenine 3-Monooxygenase; Male; Metabolic Networks and Pathways; Middle Aged; Neuroprotective Agents; Tryptophan | 2018 |
Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1.
Topics: Binding Sites; Catalytic Domain; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Models, Molecular; Protein Binding; Substrate Specificity; Tryptophan; Tryptophan Oxygenase | 2018 |
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Topics: Animals; Diabetes Mellitus, Type 2; Fatty Liver; Gastrointestinal Microbiome; Health; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin Resistance; Interleukin-22; Interleukins; Intestines; Kynurenine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Obesity; Principal Component Analysis; Tryptophan | 2018 |
The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Cognition Disorders; Executive Function; Female; Humans; Immunoglobulin A; Immunoglobulin M; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Neuropsychological Tests; Picolinic Acids; Psychiatric Status Rating Scales; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Xanthurenates; Young Adult | 2018 |
Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment.
Topics: Adult; Antiviral Agents; Depression; Depressive Disorder; Female; Hepatitis C; Hepatitis C, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Tryptophan | 2018 |
Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms.
Topics: Acetylation; Animals; Depression; Disease Models, Animal; Histones; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Mice, Inbred C57BL; Microglia; Protein Processing, Post-Translational; Serotonin; Tryptophan | 2018 |
Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain Chemistry; Cytokines; Depression; Estrogen Antagonists; Flavanones; Fluoxetine; Inflammation; Kynurenine; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Motor Activity; Olfactory Bulb; Oxidative Stress; Tryptophan | 2018 |
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Child; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2018 |
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan | 2018 |
A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode.
Topics: Biomarkers; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies; Depression; Depressive Disorder; Gastrointestinal Microbiome; Humans; Inflammation; Inpatients; Kynurenine; Male; Tryptophan | 2019 |
Dietary hydrogenated vegetable fat exacerbates the activation of kynurenine pathway caused by peripheral lipopolysaccharide immune challenge in aged mice.
Topics: Animals; Corpus Striatum; Corticosterone; Dietary Fats; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Locomotion; Male; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Transaminases; Tryptophan; Tumor Necrosis Factor-alpha; Vegetables | 2018 |
Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio.
Topics: Adult; Age Factors; Aged; Antibodies, Protozoan; Chromatography, High Pressure Liquid; Dopamine; Enzyme-Linked Immunosorbent Assay; Female; Germany; Healthy Volunteers; Humans; Immunoglobulin G; Impulsive Behavior; Kynurenine; Male; Middle Aged; Phenylalanine; Seroepidemiologic Studies; Serologic Tests; Sex Factors; Toxoplasma; Toxoplasmosis; Tryptophan; Tyrosine | 2018 |
Tryptophan, kynurenine, kynurenic acid concentrations and indoleamine 2,3-dioxygenase activity in serum and milk of dairy cows with subclinical mastitis caused by coagulase-negative staphylococci.
Topics: Animals; Case-Control Studies; Cattle; Excitatory Amino Acid Antagonists; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Mastitis, Bovine; Milk; Poland; Staphylococcal Infections; Staphylococcus; Tryptophan | 2018 |
Celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis.
Topics: Antineoplastic Agents; Cell Survival; Colonic Neoplasms; HCT116 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metabolomics; Pentacyclic Triterpenes; Triterpenes; Tryptophan | 2018 |
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Lung Neoplasms; Male; Multivariate Analysis; Programmed Cell Death 1 Receptor; Quinolinic Acid; Tryptophan | 2018 |
Plasma Indoleamine 2,3-Dioxygenase Activity Is Associated With the Size of the Human Immunodeficiency Virus Reservoir in Patients Receiving Antiretroviral Therapy.
Topics: Adult; Anti-Retroviral Agents; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; DNA, Viral; Female; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Tryptophan; Viral Load | 2019 |
Tryptophan and Kynurenine Metabolites: Are They Related to Depression?
Topics: Adult; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; ortho-Aminobenzoates; Suicide, Attempted; Tryptophan; Xanthurenates | 2019 |
The IDO genetic polymorphisms and postpartum depressive symptoms: an association study in Chinese parturients who underwent cesarean section.
Topics: Adult; Asian People; Case-Control Studies; Cesarean Section; China; Depression, Postpartum; Female; Genotype; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Polymorphism, Single Nucleotide; Pregnancy; Tryptophan | 2019 |
Determination of kynurnine and tryptophan, biomarkers of indoleamine 2,3-dioxygenase by LC-MS/MS in plasma and tumor.
Topics: Animals; Biomarkers; Blood Chemical Analysis; Chromatography, Liquid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred BALB C; Neoplasms; Tandem Mass Spectrometry; Tryptophan | 2018 |
A validated surrogate analyte LC-MS/MS assay for quantitation of endogenous kynurenine and tryptophan in human plasma.
Topics: Biomarkers; Blood Chemical Analysis; Chromatography, Liquid; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Limit of Detection; Tandem Mass Spectrometry; Tryptophan | 2018 |
A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma.
Topics: Breast Neoplasms; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Female; Humans; Kynurenine; Lymphocytes, Tumor-Infiltrating; Tryptophan; Tryptophan Oxygenase | 2019 |
[Tryptophan Metabolites in Plasma of Patients with Depression].
Topics: Bipolar Disorder; Depressive Disorder; Humans; Kynurenine; Tryptophan | 2018 |
Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression.
Topics: Administration, Intravenous; Adult; Antidepressive Agents; Bipolar Disorder; China; Chromatography, Liquid; Depression; Depressive Disorder; Female; Humans; Ketamine; Kynurenic Acid; Kynurenine; Male; Tandem Mass Spectrometry; Tryptophan | 2018 |
Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.
Topics: Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Kynurenine; MicroRNAs; Triple Negative Breast Neoplasms; Tryptophan; Tryptophan Oxygenase | 2019 |
Tryptophan Degradation and Antioxidant Status in Patients With Thyroid Disorders.
Topics: Adult; Antioxidants; Biomarkers; Case-Control Studies; Catalase; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Thyroid Diseases; Thyroid Gland; Tryptophan | 2018 |
Immunological alterations in frail older adults: A cross sectional study.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; Frail Elderly; Frailty; Humans; Kynurenine; Logistic Models; Male; Multivariate Analysis; Neopterin; Phenylalanine; Reproducibility of Results; Tryptophan | 2018 |
Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.
Topics: Animals; Cytokines; Fibroblasts; Immunity; Inflammation; Kynurenine; Lipopolysaccharides; Lung; Metabolic Networks and Pathways; Metabolome; RNA, Messenger; Swine; Tryptophan | 2018 |
ATP promotes immunosuppressive capacities of mesenchymal stromal cells by enhancing the expression of indoleamine dioxygenase.
Topics: Adenosine Triphosphate; Apyrase; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Humans; Immune Tolerance; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Mesenchymal Stem Cells; Tryptophan | 2018 |
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan | 2019 |
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.
Topics: Adult; Aged; Case-Control Studies; Central Nervous System Infections; Chromatography, Liquid; Correlation of Data; Cross-Sectional Studies; Cytokines; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Retrospective Studies; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2018 |
Macrophage de novo NAD
Topics: Aging; Animals; Cells, Cultured; Homeostasis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidative Phosphorylation; Pentosyltransferases; Phagocytosis; Signal Transduction; Tryptophan | 2019 |
Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir.
Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Central Nervous System; Cyclopropanes; Drug Substitution; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Oxazines; Piperazines; Prospective Studies; Pyridones; Tryptophan | 2019 |
Riboflavin-induced Type 1 photo-oxidation of tryptophan using a high intensity 365 nm light emitting diode.
Topics: Dimerization; Electron Transport; Free Radicals; Kinetics; Kynurenine; Lasers, Excimer; Light; Nitrogen; Oxidation-Reduction; Oxygen; Photochemical Processes; Riboflavin; Solutions; Tryptophan | 2019 |
Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis.
Topics: Acute-On-Chronic Liver Failure; Aged; Bacterial Infections; Case-Control Studies; Europe; Female; Hepatic Encephalopathy; Humans; Inflammation; Kynurenine; Liver Cirrhosis; Male; Middle Aged; Prospective Studies; Renal Insufficiency; Tryptophan | 2019 |
Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development.
Topics: Aminophenols; Animals; Antioxidants; Computational Biology; Dimerization; Drosophila melanogaster; Drosophila Proteins; Humans; Kynurenine; Metabolic Networks and Pathways; Models, Biological; Models, Molecular; Molecular Conformation; Neurotoxicity Syndromes; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Oxygen; Reactive Oxygen Species; Thermodynamics; Tryptophan | 2018 |
Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, CD; Biomarkers; C-Reactive Protein; Case-Control Studies; Chemokine CXCL10; Female; Humans; Inflammation; Interleukin-6; Kynurenine; Longitudinal Studies; Macular Degeneration; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Factors; Tryptophan | 2019 |
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age.
Topics: Aged; Aged, 80 and over; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Quinolinic Acid; Tryptophan | 2018 |
Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases.
Topics: Adolescent; Asthma; Biomarkers; Child; Child, Preschool; Dermatitis, Atopic; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypersensitivity; Immune System; Immunoglobulin E; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant; Kynurenine; Male; Neopterin; Prospective Studies; Rhinitis, Allergic; Tryptophan | 2019 |
Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS.
Topics: Animals; Cecum; Chromatography, High Pressure Liquid; Chromatography, Liquid; Gastrointestinal Contents; Kynurenine; Liver; Mass Spectrometry; Mice; Reproducibility of Results; Serotonin; Tryptophan | 2019 |
Noninvasive Serum Metabolomic Profiling Reveals Elevated Kynurenine Pathway's Metabolites in Humans with Prostate Cancer.
Topics: Aged; Biomarkers, Tumor; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; ortho-Aminobenzoates; Principal Component Analysis; Prostate-Specific Antigen; Prostatic Neoplasms; Reproducibility of Results; Tryptophan | 2019 |
Tryptophan-kynurenine profile in pediatric autoimmune hepatitis.
Topics: Adolescent; Autoantibodies; Biomarkers; Child; Child, Preschool; Female; Hepatitis, Autoimmune; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Male; Metabolic Diseases; T-Lymphocytes, Regulatory; Tryptophan | 2019 |
The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cognition; Cross-Sectional Studies; Female; Humans; Independent Living; Inflammation; Kynurenine; Male; Neopterin; Neuropsychological Tests; Signal Transduction; Tryptophan | 2019 |
Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis.
Topics: Adult; Case-Control Studies; Female; Humans; Kynurenine; Male; Metabolome; Middle Aged; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Phenylalanine; Pyrimidines; Serotonin; Tryptophan | 2019 |
Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease.
Topics: Adipose Tissue; Animals; Ataxin-7; Blood Glucose; Energy Metabolism; Humans; Kynurenine; Metabolomics; Mice; Mitochondria; Mitochondrial Diseases; NAD; Neural Stem Cells; Organelles; Peptides; Phenotype; Purkinje Cells; Reproducibility of Results; Spinocerebellar Ataxias; Trinucleotide Repeat Expansion; Tryptophan | 2019 |
The Detrimental Effects of Kynurenine, a Tryptophan Metabolite, on Human Bone Metabolism.
Topics: Aged; Aged, 80 and over; Aging; Bone and Bones; Bone Density; Bone Marrow; Bone Remodeling; Case-Control Studies; Female; Hip Fractures; Humans; Kynurenine; Male; Tryptophan | 2019 |
Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Biomarkers; Central Nervous System Infections; Cerebrospinal Fluid; Female; Humans; Inflammation; Kynurenine; Lactic Acid; Leukocyte Count; Male; Middle Aged; Tryptophan; Young Adult | 2019 |
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.
Topics: Animals; Chromatography, Liquid; Epithelial Cells; Kidney Diseases; Kidney Tubules; Kynurenine; Kynurenine 3-Monooxygenase; Metabolic Networks and Pathways; Metabolomics; Mice; Mice, Knockout; Neutrophil Infiltration; Reperfusion Injury; Tandem Mass Spectrometry; Tryptophan | 2019 |
Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; beta Catenin; Caco-2 Cells; Crotonates; Gene Knockout Techniques; Humans; Hydroxybutyrates; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Regulatory Factor-3; Kynurenine; Membrane Proteins; Mice; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; RAW 264.7 Cells; Toluidines; Toxoplasma; Toxoplasmosis; Transcription, Genetic; Transfection; Tryptophan | 2019 |
Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.
Topics: Autoantibodies; Female; Humans; Hypertension, Pulmonary; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; RNA Polymerase III; Scleroderma, Diffuse; Scleroderma, Systemic; Tryptophan | 2019 |
Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study.
Topics: Adult; Antifungal Agents; Area Under Curve; Biomarkers; Chromatography, High Pressure Liquid; Cohort Studies; Female; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Pneumocystis; Pneumonia; Prognosis; ROC Curve; Survival Rate; Tandem Mass Spectrometry; Tryptophan | 2019 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult | 2019 |
Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.
Topics: Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Citrulline; Cohort Studies; Colitis, Ulcerative; Female; Humans; Kynurenine; Male; Middle Aged; Neopterin; Quality Control; Serotonin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2019 |
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders.
Topics: Adolescent; Adult; Bipolar Disorder; Female; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Psychotic Disorders; Schizophrenia; Tryptophan; Tyrosine; Young Adult | 2020 |
Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenine; Male; Neurotransmitter Agents; Plasma; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tandem Mass Spectrometry; Toxoplasmosis; Tryptophan | 2019 |
Target exposure and pharmacodynamics study of the indoleamine 2,3-dioxygenase-1 (IDO-1) inhibitor epacadostat in the CT26 mouse tumor model.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred BALB C; Neoplasms; Oximes; Sulfonamides; Tandem Mass Spectrometry; Tryptophan | 2019 |
Elevated peripheral kynurenine/tryptophan ratio predicts poor short-term auditory memory in panic disorder patients.
Topics: Adolescent; Adult; Auditory Perception; Biomarkers; Female; Humans; Kynurenine; Male; Memory Disorders; Middle Aged; Panic Disorder; Tryptophan; Young Adult | 2019 |
How acute and chronic physical disease may influence mental health - An Analysis of neurotransmitter precursor amino acid levels.
Topics: Acute Disease; Adult; Aged; Amino Acids; Anxiety Disorders; C-Reactive Protein; Chronic Disease; Depression; Depressive Disorder; Female; Humans; Inflammation; Kynurenine; Male; Mental Disorders; Mental Health; Middle Aged; Neurotransmitter Agents; Phenylalanine; Prospective Studies; Tryptophan; Tyrosine | 2019 |
Letter to the Editor: The Kynurenine Pathway in Hepatic Cirrhosis.
Topics: Acute-On-Chronic Liver Failure; Hepatic Encephalopathy; Humans; Kynurenine; Liver Cirrhosis; Tryptophan | 2019 |
Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice.
Topics: Animals; Behavior, Animal; Citrus; Corticosterone; Diet; Hesperidin; Hippocampus; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Prefrontal Cortex; Resilience, Psychological; Social Behavior; Stress, Psychological; Tryptophan | 2019 |
Changes in tryptophan and kynurenine pathway metabolites in the blood of children treated with ketogenic diet for refractory epilepsy.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Diet, Ketogenic; Drug Resistant Epilepsy; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Male; Prospective Studies; Treatment Outcome; Tryptophan | 2019 |
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model.
Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Biphenyl Compounds; Brain; Calcium; Cytokines; Depression; Disease Models, Animal; Hindlimb Suspension; Immobilization; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Lignans; Lipopolysaccharides; Mice, Inbred ICR; NF-kappa B; RNA, Messenger; Swimming; Tryptophan | 2019 |
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms.
Topics: Adult; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Postpartum Period; Pregnancy; Psychiatric Status Rating Scales; Tryptophan | 2019 |
Kinetic evaluation of the formation of tryptophan derivatives in the kynurenine pathway during wort fermentation using Saccharomyces pastorianus and Saccharomyces cerevisiae.
Topics: Beer; Biosynthetic Pathways; Fermentation; Kinetics; Kynurenic Acid; Kynurenine; Logistic Models; Neuroprotective Agents; Plant Preparations; Saccharomyces; Saccharomyces cerevisiae; Triticum; Tryptophan | 2019 |
Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
Topics: Adenocarcinoma of Lung; Adult; Aged; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Case-Control Studies; Female; Follow-Up Studies; Humans; Inflammation; Kynurenine; Lung Neoplasms; Male; Middle Aged; Neopterin; Prognosis; Prospective Studies; Risk Factors; Small Cell Lung Carcinoma; Tryptophan | 2020 |
Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats.
Topics: Animals; Blood Chemical Analysis; Chromatography, Liquid; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Kynurenic Acid; Kynurenine; Limit of Detection; Linear Models; Male; Neurotransmitter Agents; Phenylalanine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Urinalysis | 2019 |
Elevated indoleamine-2,3-dioxygenase enzyme activity in a novel mouse model of HIV-associated atherosclerosis.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Cytokines; Diet, High-Fat; Disease Models, Animal; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice, Transgenic; Tryptophan | 2019 |
Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Case-Control Studies; Cell Differentiation; Chemotherapy, Adjuvant; Female; Humans; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Middle Aged; Proportional Hazards Models; Prospective Studies; T-Lymphocytes; Tandem Mass Spectrometry; Treatment Outcome; Tryptophan | 2019 |
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.
Topics: Aldehyde Oxidase; Animals; Cell Line, Tumor; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Kynurenine; Male; Metabolomics; Mice; NADP; Neoplasm Invasiveness; Neoplasm Staging; Nucleotides; Pentose Phosphate Pathway; RNA-Seq; Tissue Array Analysis; Tryptophan; Urinary Bladder; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2020 |
Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice.
Topics: Animals; Case-Control Studies; Dopamine; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Humans; Kynurenic Acid; Kynurenine; Male; Mice; Schizophrenia; Schizophrenic Psychology; Serotonin; Tryptophan | 2020 |
A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder.
Topics: Adult; Affect; Biomarkers; Bipolar Disorder; C-Reactive Protein; Depression; Female; Humans; Inflammation; Kynurenine; Male; Middle Aged; Symptom Assessment; Tryptophan | 2020 |
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.
Topics: Amino Acid Transport System ASC; Antineoplastic Agents; Arylformamidase; Cell Line; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Indoles; Kynurenine; Large Neutral Amino Acid-Transporter 1; Minor Histocompatibility Antigens; Oximes; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Sulfonamides; Tryptophan | 2019 |
Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma.
Topics: B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Coculture Techniques; Culture Media, Conditioned; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Metabolic Networks and Pathways; Metabolomics; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Tryptophan; Tumor Microenvironment; Up-Regulation | 2019 |
Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma.
Topics: Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Gene Knockout Techniques; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Male; Mice; Tryptophan; Tumor Burden; Tumor Escape; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Targeting tryptophan catabolic kynurenine pathway enhances antitumor immunity and cytotoxicity in multiple myeloma.
Topics: B7-H1 Antigen; Bone Marrow; Cell Line, Tumor; Dendritic Cells; Humans; Killer Cells, Natural; Kynurenine; Multiple Myeloma; T-Lymphocytes; Tryptophan | 2020 |
Assessment of neopterin and indoleamine 2,3-dioxygenase activity in patients with seasonal influenza: A pilot study.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Hospitalization; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza, Human; Kynurenine; Male; Middle Aged; Neopterin; Pilot Projects; Pneumonia; Retrospective Studies; ROC Curve; Tryptophan | 2019 |
Determination of tryptophan metabolism from biological tissues and fluids using high performance liquid chromatography with simultaneous dual electrochemical detection.
Topics: Animals; Blood; Chromatography, High Pressure Liquid; Electrochemical Techniques; Hippocampus; Ileum; Kynurenine; Male; Mice; Mice, Inbred C57BL; Serotonin; Tryptophan | 2019 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio | 2020 |
Why Am I Getting Fat? Exploring Immune-Metabolic Pathways to Central Fat Accumulation in Persons With HIV.
Topics: Abdominal Fat; HIV; HIV Infections; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Tryptophan | 2020 |
Metabolomic adaptations and correlates of survival to immune checkpoint blockade.
Topics: Adaptation, Physiological; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials as Topic; Everolimus; Female; Humans; Kaplan-Meier Estimate; Kidney Neoplasms; Kynurenine; Male; Melanoma; Metabolomics; Middle Aged; Nivolumab; Programmed Cell Death 1 Receptor; Treatment Outcome; Tryptophan | 2019 |
Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case-control study.
Topics: 3-Hydroxyanthranilic Acid; Adult; Case-Control Studies; Cohort Studies; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Niacinamide; Picolinic Acids; Serotonin; Tryptophan; Xanthurenates | 2020 |
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates | 2020 |
Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder.
Topics: Adult; Biomarkers; Bipolar Disorder; Brain; Female; Gray Matter; Humans; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Tryptophan; White Matter | 2019 |
Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats.
Topics: Animals; Carnitine; Cell Proliferation; Kynurenine; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Methylhydrazines; Mitochondria; NAD; Niacinamide; Oxidation-Reduction; Peroxisomes; Rats; Tryptophan | 2020 |
Role of indoleamine 2,3-dioxygenase in testicular immune-privilege.
Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Epididymis; Immune Privilege; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Male; Orchitis; Rats; Rats, Wistar; Sertoli Cells; Severity of Illness Index; Testis; Tryptophan; Tryptophan Oxygenase | 2019 |
Reliable detection of indoleamine 2,3 dioxygenase-1 in murine cells and tissues.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Humans; Hybridomas; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Microscopy, Fluorescence; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Staining and Labeling; Tryptophan | 2019 |
Quantification of IDO1 enzyme activity in normal and malignant tissues.
Topics: Animals; Enzyme Assays; HeLa Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neoplasms; Tryptophan; Tryptophan Oxygenase | 2019 |
The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Humans; Immunity; Kynurenic Acid; Kynurenine; Middle Aged; Tryptophan; Young Adult | 2021 |
Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation.
Topics: Aging; Animals; Cells, Cultured; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscular Atrophy; Myoblasts; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Sarcopenia; Tryptophan | 2019 |
Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Cognitive Dysfunction; Enzyme Inhibitors; Indoles; Inflammation; Kynurenine; Lipopolysaccharides; Male; Mice; Tryptophan | 2020 |
Tryptophan Intake and Tryptophan Losses in Hemodialysis Patients: A Balance Study.
Topics: Aged; Aged, 80 and over; Diet; Diet Records; Female; Humans; Kynurenine; Male; Middle Aged; Renal Dialysis; Tryptophan | 2019 |
Kynurenine elevation correlates with T regulatory cells increase in acute Plasmodium vivax infection: A pilot study.
Topics: Adult; Cross-Sectional Studies; Female; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria, Vivax; Male; Pilot Projects; Plasmodium vivax; T-Lymphocytes, Regulatory; Tryptophan | 2020 |
A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Kynurenine; Lymphocyte Activation; Neoplasms; Oligonucleotides; Oligonucleotides, Antisense; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2020 |
4,5-Disubstituted 1,2,3-triazoles: Effective Inhibition of Indoleamine 2,3-Dioxygenase 1 Enzyme Regulates T cell Activity and Mitigates Tumor Growth.
Topics: Animals; Antineoplastic Agents, Immunological; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Assays; Female; HEK293 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Kynurenine; Metabolic Networks and Pathways; Mice; Molecular Docking Simulation; Primary Cell Culture; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Triazoles; Tryptophan; Tryptophan Oxygenase; Tumor Escape | 2019 |
Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.
Topics: Animals; Antineoplastic Agents, Immunological; Cell Line, Tumor; Colonic Neoplasms; CTLA-4 Antigen; Drug Synergism; Enzyme Inhibitors; Humans; Kynurenine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; Programmed Cell Death 1 Receptor; Small Molecule Libraries; Tryptophan; Tryptophan Oxygenase | 2020 |
Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery.
Topics: Adolescent; Adult; Child; Dengue; Dengue Virus; Female; Follow-Up Studies; Humans; Kynurenine; Male; Middle Aged; Neopterin; RNA, Viral; Tryptophan; Young Adult | 2020 |
Development, validation and application of LC-MS/MS method for quantification of amino acids, kynurenine and serotonin in human plasma.
Topics: Amino Acids; Biosensing Techniques; Calibration; Chromatography, High Pressure Liquid; Humans; Kynurenine; Limit of Detection; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Serotonin; Solvents; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan | 2020 |
Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo.
Topics: Aging; Animals; Bone and Bones; Bone Density; Cell Differentiation; Female; Histone Deacetylases; Kynurenine; Male; Mice; Osteoblasts; Osteoporosis; Sex Characteristics; Tryptophan | 2020 |
Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.
Topics: Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immune Tolerance; Kynurenine; Lymphocyte Activation; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2019 |
Simultaneous voltammetric analysis of tryptophan and kynurenine in culture medium from human cancer cells.
Topics: Biosensing Techniques; Boron; Cell Culture Techniques; Cell Line, Tumor; Chromatography, High Pressure Liquid; Culture Media; Diamond; Electrochemical Techniques; Electrodes; Humans; Kynurenine; Neoplasms; Tryptophan | 2020 |
Tryptophane-kynurenine pathway in the remote ischemic conditioning mechanism.
Topics: Animals; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Kynurenine; Liver; Male; Muscle, Skeletal; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats, Wistar; Tryptophan | 2020 |
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression.
Topics: Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2020 |
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.
Topics: Allosteric Regulation; Allosteric Site; Animals; Biocatalysis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Male; Mice, Knockout; Multiple Sclerosis; Serotonin; Tryptophan | 2020 |
Tryptophan Co-Metabolism at the Host-Pathogen Interface.
Topics: Animals; Host Microbial Interactions; Immunologic Factors; Kynurenine; Microbiota; Tryptophan | 2020 |
Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclic N-Oxides; Cyclin-Dependent Kinases; Gene Expression Regulation, Neoplastic; Glioblastoma; Head and Neck Neoplasms; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indolizines; Interferon-gamma; Kynurenine; Metabolic Networks and Pathways; Neoplasms; Pyridinium Compounds; Tryptophan; Tryptophan Oxygenase | 2020 |
Up-regulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients.
Topics: Adult; Aged; Aged, 80 and over; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; CTLA-4 Antigen; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphatic Metastasis; Male; Middle Aged; Penile Neoplasms; Prognosis; Survival Rate; Tryptophan; Up-Regulation; Young Adult | 2020 |
Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis.
Topics: Adult; Biomarkers; Female; Gastrointestinal Microbiome; Humans; Italy; Kynurenine; Male; Metabolomics; Multiple Sclerosis; ortho-Aminobenzoates; Prospective Studies; Recurrence; Serotonin; Tryptophan; Young Adult | 2020 |
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan | 2020 |
Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kynurenine; Metabolic Networks and Pathways; MicroRNAs; Middle Aged; RNA, Long Noncoding; Tryptophan; Tryptophan Oxygenase | 2020 |
Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway.
Topics: Animals; Antidepressive Agents; Behavior Observation Techniques; Behavior, Animal; Benzoquinones; Depression; Disease Models, Animal; Drug Carriers; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipids; Male; Nanoparticles; Nigella sativa; Rats; Serotonin; Signal Transduction; Tryptophan | 2020 |
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Homeostasis; Immunosuppressive Agents; Kynurenine; Male; Mice; Mice, Inbred C57BL; Sulfates; Trinitrobenzenes; Tryptophan | 2020 |
Topics: Brain; Cell Physiological Phenomena; Homeostasis; Immune System; Kynurenine; Tryptophan | 2020 |
Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones.
Topics: Animals; Hippocampus; Hypothalamo-Hypophyseal System; Kynurenine; Ozone; Pituitary-Adrenal System; Rats; Receptors, Serotonin; Tryptophan; Vascular Endothelial Growth Factor A | 2020 |
Cerebrospinal Fluid Neurofilament Light Chain Is Associated with Kynurenine Pathway Metabolite Changes in Multiple Sclerosis.
Topics: Biomarkers; Brain; Enzyme-Linked Immunosorbent Assay; Humans; Kynurenine; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Multiple Sclerosis; Neopterin; Neurofilament Proteins; ROC Curve; Tryptophan | 2020 |
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Angiotensins; Correlation of Data; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kynurenine; Male; Renal Insufficiency, Chronic; Renin; Tryptophan | 2020 |
Synthesis and Preclinical Evaluation of 6-[
Topics: Animals; Fluorine; Kynurenine; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Tryptophan | 2020 |
Preliminary comparative analysis of kynurenine pathway metabolites in chronic ketamine users, schizophrenic patients, and healthy controls.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Ketamine; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Substance-Related Disorders; Tandem Mass Spectrometry; Time Factors; Tryptophan; Young Adult | 2020 |
Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.
Topics: Adolescent; Adult; Aged; Aging; Alcohol Abstinence; Alcoholism; Body Mass Index; Cross-Sectional Studies; Diagnosis, Dual (Psychiatry); Female; Humans; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Metabolic Networks and Pathways; Middle Aged; Serotonin; Sex Characteristics; Tryptophan; Young Adult | 2020 |
Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls.
Topics: Aged; Case-Control Studies; Female; Humans; Hydroxyindoleacetic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Monoamine Oxidase; Organ Dysfunction Scores; Prospective Studies; Serotonin; Shock, Septic; Survival Rate; Tryptophan | 2020 |
Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients.
Topics: Aged; Depression; Female; Humans; Kynurenine; Male; Middle Aged; Motor Cortex; Psychiatric Status Rating Scales; Stroke; Transcranial Magnetic Stimulation; Tryptophan | 2020 |
Seasonality of plasma tryptophan and kynurenine in pregnant mothers with a history of seasonal affective disorder: Vulnerability or adaptation?
Topics: Female; Humans; Kynurenine; Mothers; Plasma; Pregnancy; Seasonal Affective Disorder; Tryptophan | 2020 |
l-Tryptophan-Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Arteries; Carrier Proteins; Cytokines; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Maternal-Fetal Exchange; Nitric Oxide; Nitric Oxide Synthase; Placenta; Pre-Eclampsia; Pregnancy; RNA, Messenger; Tryptophan; Vasodilation | 2020 |
Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion.
Topics: Animals; Autoantibodies; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Plant Extracts; Prunella; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes, Regulatory; Thyroid Gland; Thyroiditis, Autoimmune; Tryptophan | 2020 |
Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Kynurenine; Mass Spectrometry; Metabolome; Metabolomics; Reference Standards; Reproducibility of Results; Tryptophan | 2020 |
Prenatal IL-6 levels and activation of the tryptophan to kynurenine pathway are associated with depressive but not anxiety symptoms across the perinatal and the post-partum period in a low-risk sample.
Topics: Anxiety; Female; Humans; Interleukin-6; Kynurenine; Postpartum Period; Pregnancy; Tryptophan | 2020 |
Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neurons; Rats; Receptors, Aryl Hydrocarbon; Tryptophan | 2020 |
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.
Topics: Adult; Aged; Amino Acids; Betacoronavirus; Blood Glucose; Case-Control Studies; Coronavirus Infections; COVID-19; Creatine; Creatinine; Cystine; Fatty Acids; Fatty Acids, Nonesterified; Female; Humans; Interleukin-6; Kynurenine; Male; Metabolome; Metabolomics; Methionine; Middle Aged; Oxidative Stress; Pandemics; Pneumonia, Viral; Polyamines; Proteolysis; Renal Insufficiency; SARS-CoV-2; Tryptophan | 2020 |
Rickettsial pathogen uses arthropod tryptophan pathway metabolites to evade reactive oxygen species in tick cells.
Topics: Anaplasma phagocytophilum; Animals; Hemin; Host-Pathogen Interactions; Hydrolases; Ixodes; Kynurenic Acid; Kynurenine; NADP; Reactive Oxygen Species; RNA Interference; Transaminases; Tryptophan; Tryptophan Oxygenase; Up-Regulation; Xanthurenates | 2020 |
Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Crystallography, X-Ray; Drug Discovery; Female; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Neoplasms; Structure-Activity Relationship; T-Lymphocytes, Cytotoxic; Tryptophan; Xenograft Model Antitumor Assays | 2020 |
Label-free detection of thalassemia and other ROS impairing diseases.
Topics: Algorithms; Arthritis, Rheumatoid; Humans; Kynurenine; NAD; Oxidative Stress; Principal Component Analysis; Reactive Oxygen Species; ROC Curve; Spectrometry, Fluorescence; Spectrum Analysis, Raman; Thalassemia; Tryptophan | 2020 |
Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease.
Topics: Biomarkers; Humans; Kynurenine; Parkinson Disease; Substantia Nigra; Tryptophan | 2020 |
The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Indican; Indoles; Kynurenine; Mendelian Randomization Analysis; Renal Insufficiency, Chronic; Tryptophan | 2020 |
Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biotransformation; Cross-Sectional Studies; HIV Infections; Homosexuality, Male; Humans; Impulsive Behavior; Kynurenine; Male; Methamphetamine; Middle Aged; Phenylalanine; Psychological Tests; Risk-Taking; Substance-Related Disorders; Tryptophan; Tyrosine; Viral Load | 2020 |
Novel immune biomarkers in complex regional pain syndrome.
Topics: Adult; Aged; Biomarkers; Complex Regional Pain Syndromes; Female; Humans; Interleukin-1; Kynurenine; Machine Learning; Male; Middle Aged; Pilot Projects; Tryptophan; Tumor Necrosis Factor-alpha | 2020 |
Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor: Short title: Kynurenine action on human decidualization.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Insulin-Like Growth Factor Binding Protein 1; Interferon-gamma; Kynurenine; Large Neutral Amino Acid-Transporter 1; Prolactin; Receptors, Aryl Hydrocarbon; Stromal Cells; Tryptophan; Tryptophan Hydroxylase | 2020 |
Effect of IFN-γ on the kynurenine/tryptophan ratio in monolayer-cultured keratinocytes and a 3D reconstructed human epidermis model.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Epidermis; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-6; Interleukin-8; Keratinocytes; Kynurenine; Metabolic Networks and Pathways; Primary Cell Culture; Recombinant Proteins; Tryptophan | 2020 |
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
Topics: Carotid Artery Diseases; Down-Regulation; Humans; Inflammation; Kynurenic Acid; Kynurenine; Macrophages; Plaque, Atherosclerotic; Tryptophan; Up-Regulation | 2021 |
Tryptophan-kynurenine ratio as a biomarker of bladder cancer.
Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Correlation of Data; Female; Humans; Kynurenine; Male; Middle Aged; Tryptophan; Urinary Bladder Neoplasms | 2021 |
Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis.
Topics: Adult; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; Humans; Kynurenine; Latent Tuberculosis; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Tryptophan; Tuberculosis, Pulmonary | 2020 |
Kynurenines link chronic inflammation to functional decline and physical frailty.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Chronic Disease; Cytokines; Disease Models, Animal; Female; Frail Elderly; Humans; Inflammation; Interleukin-10; Kynurenine; Male; Mice, Inbred C57BL; Middle Aged; Neuromuscular Junction; Serotonin; Tryptophan; Walking Speed; Young Adult | 2020 |
Modulation of the Paracrine Kynurenic System in Bone as a New Regulator of Osteoblastogenesis and Bone Mineral Status in an Animal Model of Chronic Kidney Disease Treated with LP533401.
Topics: Animals; Bone Diseases, Metabolic; Calcification, Physiologic; Kynurenine; Male; Mice; Osteoblasts; Osteogenesis; Paracrine Communication; Pyrimidines; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Serotonin; Serotonin Agents; Tryptophan; Tryptophan Oxygenase; Vitamin D | 2020 |
Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients.
Topics: Adolescent; Adult; Biopsy; C-Reactive Protein; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Ileum; Intestinal Mucosa; Kynurenine; Male; Middle Aged; Serotonin; Severity of Illness Index; Tryptophan; Young Adult | 2020 |
Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice.
Topics: Animals; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Male; Metabolic Networks and Pathways; Metabolomics; Mice, Knockout; ortho-Aminobenzoates; Serotonin; Spleen; Tryptophan; Tryptophan Oxygenase | 2020 |
Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child, Preschool; Chromatography, Liquid; Humans; Infant; Kynurenine; Mass Spectrometry; Metabolomics; Prospective Studies; Serotonin; Tryptophan | 2020 |
Involvement of kynurenine pathway in depressive-like behaviour induced by nandrolone decanoate in mice.
Topics: Anabolic Agents; Animals; Behavior, Animal; Corpus Striatum; Depression; Dose-Response Relationship, Drug; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred C57BL; Nandrolone Decanoate; Prefrontal Cortex; Tryptophan | 2020 |
1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
Topics: Aged; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Urinary Bladder Neoplasms | 2020 |
Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus.
Topics: Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Chemokine CXCL10; HIV Infections; Humans; Immune System; Interleukin-6; Kynurenine; Lipopolysaccharide Receptors; Male; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor, Type II; Receptors, Urokinase Plasminogen Activator; Tryptophan | 2021 |
Clinical significance of tryptophan catabolism in follicular lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Female; Humans; Immunohistochemistry; Kynurenine; Lymphatic Metastasis; Lymphoma, Follicular; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Prognosis; Tryptophan; Tumor Microenvironment | 2020 |
LC-QTOF/MS determination of tryptophan and kynurenine in infant formulas.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Infant Formula; Infant, Newborn; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2020 |
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa.
Topics: Adult; Axilla; Female; Fibroblasts; Hidradenitis Suppurativa; Host Microbial Interactions; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Receptors, Aryl Hydrocarbon; Skin; Tryptophan | 2020 |
C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Cognitive Dysfunction; Female; Humans; Inflammation; Inflammation Mediators; Kynurenine; Linear Models; Male; Mental Disorders; Middle Aged; Neuropsychological Tests; Predictive Value of Tests; Psychomotor Performance; Reaction Time; Stroop Test; Trail Making Test; Tryptophan; Young Adult | 2020 |
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oximes; Peptide Fragments; Quinolinic Acid; Sulfonamides; Tryptophan | 2020 |
Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
Topics: Animals; Antiviral Agents; Female; Hepatitis Viruses; Hepatitis, Viral, Animal; Hepatocytes; Humans; Immunity, Innate; Inflammation; Interferon Regulatory Factor-7; Kynurenine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Interferon alpha-beta; STAT1 Transcription Factor; Tryptophan; Tryptophan Oxygenase | 2020 |
Neopterin and biopterin levels and tryptophan degradation in patients with diabetes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopterins; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Kynurenine; Male; Metformin; Middle Aged; Neopterin; Tryptophan; Vildagliptin; Young Adult | 2020 |
Tryptophan Intake and Metabolism in Older Adults with Mood Disorders.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Depression; Dietary Supplements; Eating; Female; Humans; Kynurenine; Male; Middle Aged; Mood Disorders; Nutritional Physiological Phenomena; Serotonin; Severity of Illness Index; Signal Transduction; Tryptophan | 2020 |
Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder.
Topics: Autism Spectrum Disorder; Child, Preschool; Humans; Infant; Kynurenic Acid; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2022 |
Alterations in plasma kynurenine pathway metabolites in children and adolescents with bipolar disorder and unaffected offspring of bipolar parents: A preliminary study.
Topics: Adolescent; Adult; Bipolar Disorder; Child; Humans; Kynurenic Acid; Kynurenine; Parents; Tryptophan | 2021 |
HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment.
Topics: Chromatography, High Pressure Liquid; Hydrophobic and Hydrophilic Interactions; Indoles; Kynurenine; Principal Component Analysis; Tryptophan | 2021 |
Tryptophan catabolism to serotonin and kynurenine in women undergoing in-vitro fertilization.
Topics: Adult; Cross-Sectional Studies; Endometriosis; Female; Fertilization in Vitro; Humans; Kynurenine; Ovulation Induction; Pregnancy; Serotonin; Tryptophan | 2020 |
The evaluation of serum tryptophan and kynurenine levels in patients with obstructive sleep apnea syndrome.
Topics: Adult; Aged; Female; Humans; Kynurenine; Male; Middle Aged; Sleep Apnea, Obstructive; Tryptophan | 2021 |
The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer.
Topics: Arginine; Helicobacter pylori; Humans; Kynurenine; Ligands; Receptors, Aryl Hydrocarbon; Stomach Neoplasms; Tryptophan | 2022 |
Plasma Kynurenine to Tryptophan Ratio Is Negatively Associated with Linear Growth of Children Living in a Slum of Bangladesh: Results from a Community-Based Intervention Study.
Topics: Bangladesh; Biomarkers; Chromatography, Liquid; Cohort Studies; Female; Growth and Development; Growth Disorders; Humans; Infant; Inflammation; Kynurenine; Male; Plasma; Poverty Areas; Tryptophan | 2020 |
Decreased IDO1-dependent tryptophan metabolism in aged lung during influenza.
Topics: Aged; Aged, 80 and over; Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza, Human; Kynurenine; Lung; Mice; Tryptophan | 2021 |
Serum neopterin levels in relation to mild and severe COVID-19.
Topics: Adult; Aged; Biomarkers; COVID-19; Critical Care; Female; Hospitalization; Humans; Kynurenine; Male; Middle Aged; Neopterin; Pandemics; Prognosis; SARS-CoV-2; Tryptophan | 2020 |
Cerebrospinal fluid metabolites in tryptophan-kynurenine and nitric oxide pathways: biomarkers for acute neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Encephalitis, Viral; Encephalomyelitis, Acute Disseminated; Female; Humans; Infant; Kynurenine; Male; Nitric Oxide; Tryptophan | 2021 |
Increased kynurenine-to-tryptophan ratio in the serum of patients infected with SARS-CoV2: An observational cohort study.
Topics: Aged; Biomarkers; COVID-19; Female; Humans; Kynurenine; Lymphocyte Count; Male; Middle Aged; SARS-CoV-2; Tryptophan | 2021 |
Central levels of tryptophan metabolites in subjects with bipolar disorder.
Topics: Bipolar Disorder; Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2021 |
Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.
Topics: Bacterial Proteins; Binding Sites; Biosynthetic Pathways; Carboxy-Lyases; Catalytic Domain; Crystallography, X-Ray; Diflunisal; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kynurenine; Molecular Docking Simulation; NAD; Pseudomonas fluorescens; Structure-Activity Relationship; Tryptophan | 2021 |
[The study of tryptophan metabolite concentrations in blood serum and fecal extracts from obese children].
Topics: Child; Humans; Kynurenine; Pediatric Obesity; Plant Extracts; Tryptophan | 2020 |
Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Line, Tumor; Chemotherapy, Adjuvant; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immune Checkpoint Inhibitors; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Neoplasms; Kynurenine; Male; Middle Aged; Nephrectomy; Progression-Free Survival; Tryptophan; Tryptophan Oxygenase | 2021 |
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.
Topics: Alzheimer Disease; Biological Availability; Humans; Kynurenine; Serotonin; Tryptophan | 2021 |
Non-invasive skin sampling of tryptophan/kynurenine ratio in vitro towards a skin cancer biomarker.
Topics: Animals; Biomarkers, Tumor; Cell Membrane Permeability; Electric Conductivity; Kynurenine; Skin; Skin Neoplasms; Swine; Tryptophan | 2021 |
The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin.
Topics: Adult; Antiviral Agents; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Hepatitis C, Chronic; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-alpha; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; ortho-Aminobenzoates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tryptophan | 2021 |
Tryptophan Derivatives by
Topics: Chromatography, Liquid; Culture Media; Fermentation; Glycine max; Humans; Kynurenic Acid; Kynurenine; Melatonin; Neurotransmitter Agents; Saccharomyces cerevisiae; Signal Transduction; Tandem Mass Spectrometry; Tryptophan | 2021 |
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glaucoma; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Metabolic Networks and Pathways; Mice; Retina; Species Specificity; Tryptophan | 2021 |
Indoleamine 2,3-Dioxygenase Activity-Induced Acceleration of Tumor Growth, and Protein Kinases-Related Novel Therapeutics Regimens.
Topics: Acceleration; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Protein Kinases; Tryptophan | 2021 |
Metabolic Stress and Immunity: Nutrient-Sensing Kinases and Tryptophan Metabolism.
Topics: Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Nutrients; Protein Serine-Threonine Kinases; Stress, Physiological; Tryptophan | 2021 |
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis.
Topics: Biomarkers; Cholangitis, Sclerosing; Chromatography, Liquid; Cross-Sectional Studies; Humans; Kynurenine; Neopterin; Tandem Mass Spectrometry; Tryptophan | 2021 |
Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melanoma, Experimental; Mice; Small Molecule Libraries; Tryptophan | 2020 |
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Psychometrics; Quinolinic Acid; Tryptophan | 2021 |
Early-Life Stress Modulates Gut Microbiota and Peripheral and Central Inflammation in a Sex-Dependent Manner.
Topics: Animals; Animals, Newborn; Cytokines; Female; Gastrointestinal Microbiome; Hippocampus; Inflammation; Kynurenine; Male; Maternal Deprivation; Population Dynamics; Rats, Sprague-Dawley; RNA, Ribosomal, 16S; Sex Factors; Staphylococcus; Streptococcus; Stress, Psychological; Tryptophan | 2021 |
Development and validation of a liquid chromatography method using UV/fluorescence detection for the quantitative determination of metabolites of the kynurenine pathway in human urine: Application to patients with heart failure.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Heart Failure; Humans; Kynurenine; Male; Pilot Projects; Tryptophan | 2021 |
Methylene blue and ascorbate interfere with the accurate determination of the kinetic properties of IDO2.
Topics: Biocatalysis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Methylene Blue; Oxidation-Reduction; Tryptophan | 2021 |
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics.
Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Kynurenine; Male; Methionine; Methylation; Probiotics; Rats; Rats, Sprague-Dawley; Tryptophan | 2021 |
Plasma Kynurenine-to-Tryptophan Ratio, a Highly Sensitive Blood-Based Diagnostic Tool for Tuberculosis in Pregnant Women Living With Human Immunodeficiency Virus (HIV).
Topics: Diagnostic Tests, Routine; Female; HIV; HIV Infections; Humans; Kynurenine; Pregnancy; Pregnant Women; Tryptophan; Tuberculosis | 2021 |
Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats.
Topics: Animals; Colon; Homeostasis; Humans; Kynurenic Acid; Kynurenine; Rats; Tryptophan | 2021 |
Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.
Topics: Humans; Kynurenic Acid; Kynurenine; Memory, Short-Term; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
The Tryptophan/Kynurenine Pathway: A Novel Cross-Talk between Nutritional Obesity, Bariatric Surgery and Taste of Fat.
Topics: Adult; Animals; Dietary Fats; Female; Food Preferences; Gastrectomy; Humans; Kynurenine; Male; Metabolome; Mice; Obesity; Postoperative Period; Signal Transduction; Taste Disorders; Taste Perception; Tryptophan | 2021 |
Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer.
Topics: Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Survival Rate; Tryptophan | 2021 |
Abdominal Obesity-Related Disturbance of Insulin Sensitivity Is Associated with CD8
Topics: Adipokines; Biomarkers; Body Mass Index; Case-Control Studies; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Cytokines; Female; Humans; Immunologic Memory; Insulin Resistance; Kynurenine; Leukocyte Common Antigens; Male; Middle Aged; Obesity, Abdominal; Tryptophan | 2021 |
A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenine; Pharmaceutical Preparations; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2021 |
Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients.
Topics: Adult; Aged; Biomarkers; Ceramides; COVID-19; Female; Hospitalization; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; Prospective Studies; SARS-CoV-2; Severity of Illness Index; Tryptophan | 2021 |
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.
Topics: Adult; Case-Control Studies; Cognition; Cognitive Dysfunction; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Tryptophan; Young Adult | 2021 |
Canine mast cell tumour cells regulate tryptophan catabolism via the expression of indoleamine 2,3-dioxygenase.
Topics: Animals; Cell Line, Tumor; Dog Diseases; Dogs; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mast Cells; Metabolism; Neoplasms; Tryptophan | 2021 |
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cell Death; Gastrointestinal Microbiome; Humans; Immunologic Factors; Immunotherapy; Kynurenine; Ligands; Lung Neoplasms; Mice; Panax; Polysaccharides; Tryptophan | 2022 |
The kynurenine pathway in schizophrenia and other mental disorders: Insight from meta-analyses on the peripheral blood levels of tryptophan and related metabolites.
Topics: Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Schizophrenia; Tryptophan | 2021 |
Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Exercise; Female; Humans; Kynurenic Acid; Kynurenine; Male; Mass Spectrometry; Middle Aged; Sweat; Tryptophan | 2021 |
Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams.
Topics: Animals; Corticosterone; Depression, Postpartum; Depressive Disorder, Major; Female; Fluoxetine; Humans; Kynurenine; Postpartum Period; Pregnancy; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tryptophan | 2021 |
Disruption of kynurenine pathway reveals physiological importance of tryptophan catabolism in Henosepilachna vigintioctopunctata.
Topics: Animals; Biosynthetic Pathways; Coleoptera; Eye Color; Insect Proteins; Kynurenine; Larva; Locomotion; Phenothiazines; Tryptophan | 2021 |
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.
Topics: Bacteria; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Gastrointestinal Microbiome; Humans; Kynurenine; Lactase; Tryptophan | 2022 |
Lanosterol reduces the aggregation propensity of ultraviolet-damaged human γD-crystallins: a molecular dynamics study.
Topics: gamma-Crystallins; Humans; Kynurenine; Molecular Dynamics Simulation; Molecular Structure; Tryptophan; Ultraviolet Rays | 2021 |
Structural Basis of Selective Human Indoleamine-2,3-dioxygenase 1 (hIDO1) Inhibition.
Topics: Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tryptophan | 2021 |
Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Kynurenic Acid; Kynurenine; Methylphenidate; Tryptophan | 2021 |
Circulating tryptophan metabolites and risk of colon cancer: Results from case-control and prospective cohort studies.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Colonic Neoplasms; Female; Humans; Kynurenine; Logistic Models; Male; Middle Aged; Prospective Studies; Risk Factors; Serotonin; Tryptophan | 2021 |
UHPLC-ESI-MS/MS Quantification of Relevant Substrates and Metabolites of the Kynurenine Pathway Present in Serum and Peritoneal Fluid from Gastric Cancer Patients-Method Development and Validation.
Topics: Ascitic Fluid; Chromatography, High Pressure Liquid; Humans; Kynurenine; Stomach Neoplasms; Tandem Mass Spectrometry; Trichloroacetic Acid; Tryptophan | 2021 |
Chromatographic method for the determination of inflammatory biomarkers and uric acid in human saliva.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Humans; Kynurenine; Saliva; Tryptophan; Uric Acid | 2021 |
Gut ACE2 Expression, Tryptophan Deficiency, and Inflammatory Responses The Potential Connection That Should Not Be Ignored During SARS-CoV-2 Infection.
Topics: Angiotensin-Converting Enzyme 2; Animals; COVID-19; Cytokines; Epithelial Cells; Inflammation; Intestinal Mucosa; Intestines; Kynurenine; Lipopolysaccharides; Mice; Mice, Knockout; Phenotype; Recombinant Proteins; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Tryptophan | 2021 |
Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.
Topics: Animals; Cystathionine beta-Synthase; Heme; Hemin; Homocysteine; Humans; Kynurenine; Nutritional Status; Porphyrias, Hepatic; Treatment Outcome; Tryptophan; Vitamin B Complex | 2021 |
The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation.
Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2021 |
Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes.
Topics: Adolescent; Child; Chromatography, Liquid; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Glucose; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2021 |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Topics: Animals; Biogenic Amines; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Humans; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Kynurenine; Mice; Nephritis; NF-kappa B; Psoriasis; Tryptophan | 2021 |
The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene.
Topics: Animals; Biomarkers; C-Reactive Protein; Inflammation; Kynurenine; Male; Mice; Polymorphism, Single Nucleotide; Tryptophan | 2021 |
Altered kynurenine pathway metabolism in patients with ankylosing spondylitis.
Topics: Adult; C-Reactive Protein; Case-Control Studies; Female; Healthy Volunteers; Humans; Interleukin-6; Kynurenine; Male; Metabolic Networks and Pathways; Middle Aged; Spondylitis, Ankylosing; Tryptophan; Tumor Necrosis Factor Inhibitors | 2021 |
Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward.
Topics: Animals; Cerebellum; Cocaine; Conditioning, Operant; Environment; Indomethacin; Kynurenine; Male; Mice; Mice, Inbred C57BL; Oxytocin; Resilience, Psychological; Reward; Signal Transduction; Social Defeat; Tryptophan | 2021 |
Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity.
Topics: Adipose Tissue; Animals; Biomarkers; Cytokines; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Energy Metabolism; Hepatocytes; Indoleamine-Pyrrole 2,3,-Dioxygenase; Insulin; Interleukin-6; Kynurenine; Male; Mice; Obesity; Receptors, Interleukin-6; Tryptophan | 2021 |
Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway.
Topics: Animals; Hypoxia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ischemia; Kidney; Kynurenine; Metabolome; Mice, Inbred C57BL; Mice, Knockout; NAD; Procollagen-Proline Dioxygenase; Protective Agents; Tryptophan | 2021 |
Monitoring the kynurenine system: Concentrations, ratios or what else?
Topics: Biomarkers; Kynurenine; Tryptophan | 2021 |
Immunometabolic signatures predict risk of progression to sepsis in COVID-19.
Topics: Adult; Area Under Curve; Chemokines; COVID-19; Cytokines; Female; Humans; Kynurenine; Lymphocytes; Male; Metabolomics; Middle Aged; Neutrophils; Retrospective Studies; Risk Factors; ROC Curve; SARS-CoV-2; Sepsis; Severity of Illness Index; Tryptophan | 2021 |
Investigation of the Relationship among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior.
Topics: Cytokines; Depressive Disorder, Major; Humans; Hydrocortisone; Interleukin-1; Interleukin-12; Kynurenine; Suicide, Attempted; Tryptophan | 2022 |
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred DBA; Mice, Knockout; Phenotype; Tryptophan; Tryptophan Oxygenase | 2021 |
Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFNγ-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma.
Topics: Adult; Cells, Cultured; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Male; Melanoma; Middle Aged; Monocytes; Neoplasm Recurrence, Local; Neoplasm Staging; Retrospective Studies; Skin Neoplasms; Time Factors; Treatment Outcome; Tryptophan; Tumor Escape | 2021 |
Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase.
Topics: Hydrogen Bonding; Iron; Kynurenine; Oxidation-Reduction; Protein Binding; Stereoisomerism; Tryptophan; Tryptophan Oxygenase; Xanthomonas campestris | 2021 |
Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.
Topics: Acute Disease; Adult; Amino Acids; Body Mass Index; Carnitine; Cohort Studies; COVID-19; Fatty Acids; Female; Humans; Kynurenine; Machine Learning; Metabolomics; Middle Aged; Prognosis; Prospective Studies; SARS-CoV-2; Severity of Illness Index; Tryptophan | 2021 |
Increased Indoleamine 2,3-Dioxygenase Levels at the Onset of Sjögren's Syndrome in SATB1-Conditional Knockout Mice.
Topics: Animals; Cytokines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Interferon-gamma; Kynurenine; Matrix Attachment Region Binding Proteins; Mice, Inbred C57BL; Mice, Knockout; Saliva; Salivary Glands; Sjogren's Syndrome; Tryptophan; Up-Regulation | 2021 |
Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies.
Topics: Female; Fetus; Human Umbilical Vein Endothelial Cells; Humans; Kynurenine; Pre-Eclampsia; Pregnancy; Tryptophan | 2022 |
Differentiation of viral and autoimmune central nervous system inflammation by kynurenine pathway.
Topics: Adult; Aged; Aged, 80 and over; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Biomarkers; Encephalitis, Herpes Simplex; Encephalitis, Varicella Zoster; Female; Humans; Hydrocephalus, Normal Pressure; Kynurenine; Male; Meningitis, Viral; Middle Aged; Multiple Sclerosis; Pseudotumor Cerebri; Signal Transduction; Tryptophan; Young Adult | 2021 |
Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol.
Topics: Humans; Kynurenine; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals; Tryptophan | 2021 |
Interferon-γ Impairs Human Coronary Artery Endothelial Glucose Metabolism by Tryptophan Catabolism and Activates Fatty Acid Oxidation.
Topics: Biomarkers; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Vessels; Endothelial Cells; Energy Metabolism; Fatty Acids; Gene Expression Regulation; Glucose; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interferon-gamma; Kynurenine; Oxidation-Reduction; Protein Binding; Signal Transduction; Tryptophan | 2021 |
Kynurenine to tryptophan ratio as a biomarker of acute stress in fish.
Topics: Biomarkers; Kynurenine; Tryptophan | 2022 |
Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner.
Topics: Animals; ATP-Binding Cassette Transporters; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Nucleus; Disease Progression; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, myc; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Prostatic Neoplasms; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Tryptophan; Up-Regulation | 2021 |
δ
Topics: Biomarkers; Depressive Disorder, Major; Heart Rate; Humans; Kynurenine; Quinolinic Acid; Reproducibility of Results; Sensitivity and Specificity; Stress, Physiological; Tryptophan | 2021 |
Activation of the kynurenine pathway predicts mortality and neurological outcome in cardiac arrest patients: A validation study.
Topics: Cohort Studies; Heart Arrest; Hospital Mortality; Humans; Kynurenine; Tryptophan | 2022 |
Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus.
Topics: Cognitive Dysfunction; Cross-Sectional Studies; Humans; Kynurenine; Lupus Erythematosus, Systemic; Neuropsychological Tests; Quinolinic Acid; Tryptophan | 2021 |
The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus).
Topics: Animals; Diet; Female; Glycogen; Gryllidae; Kynurenine; Male; Monosaccharides; Mutation; Pigmentation; Tryptophan | 2021 |
Kynurenine inhibits melanogenesis in human melanocyte-keratinocyte co-cultures and in a reconstructed 3D skin model.
Topics: Coculture Techniques; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Keratinocytes; Kynurenine; Melanocytes; Tryptophan | 2022 |
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.
Topics: Animals; Aorta; Carotid Artery Injuries; Carotid Artery Thrombosis; Culture Media; Enzyme Induction; Feedback, Physiological; Female; HEK293 Cells; Humans; Indican; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Myocytes, Smooth Muscle; Postoperative Complications; Renal Insufficiency, Chronic; Thromboplastin; Thrombosis; Tryptophan; Uremia; Vascular Surgical Procedures | 2021 |
Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson's disease.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Parkinson Disease; Tryptophan; Tryptophan Oxygenase | 2021 |
Deregulated kynurenine metabolism - An alternate hypothesis for COVID-19 associated anosmia.
Topics: Anosmia; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; SARS-CoV-2; Tryptophan | 2021 |
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
Topics: Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Disease Models, Animal; Hindlimb; Humans; Indican; Ischemia; Kynurenine; Mice; Middle Aged; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan; Wnt Signaling Pathway | 2022 |
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
Topics: Adolescent; Adult; Aged; Chemokine CXCL9; Female; Fibrosis; Gene Expression Regulation; Graft vs Host Disease; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-18; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Leukemia; Lymphoma; Male; Metabolic Networks and Pathways; Middle Aged; ortho-Aminobenzoates; Retrospective Studies; Riboflavin; Severity of Illness Index; Signal Transduction; Stem Cell Transplantation; Transplantation, Homologous; Tryptophan; Vitamin B 6 | 2021 |
Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition.
Topics: Adult; Anxiety; Bile Acids and Salts; Chromatography, Liquid; Depression; Dietary Fiber; Fatty Acids, Volatile; Feasibility Studies; Feces; Female; Gastrointestinal Microbiome; Humans; Kynurenic Acid; Kynurenine; Mental Health; Perinatal Care; Pilot Projects; Pregnancy; Tandem Mass Spectrometry; Tryptophan | 2022 |
The immune-kynurenine pathway in social anxiety disorder.
Topics: Female; Humans; Kynurenic Acid; Kynurenine; Male; Phobia, Social; Schizophrenia; Tryptophan | 2022 |
Elucidation of the Central Serotonin Metabolism Pathway in Rhesus Macaques (
Topics: Animals; Humans; Kynurenine; Macaca mulatta; Self-Injurious Behavior; Serotonin; Tryptophan | 2021 |
Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest.
Topics: Animals; Brain; Cardiopulmonary Resuscitation; Functional Status; Heart Arrest; Kynurenine; Rats; Treatment Outcome; Tryptophan | 2021 |
Content of tryptophan and kynurenines in serum and milk of dairy cows with mastitis caused by Streptococcus spp.
Topics: Animals; Cattle; Cattle Diseases; Female; Kynurenine; Mastitis; Milk; Streptococcus; Tryptophan | 2022 |
Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression.
Topics: Biomarkers; Bipolar Disorder; Cytokines; Depressive Disorder, Major; Humans; Kynurenine; Tryptophan; White Matter | 2022 |
Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infection.
Topics: Adult; Aged; Area Under Curve; Carnitine; Citrulline; COVID-19; Female; Glutamic Acid; Humans; Kynurenine; Male; Metabolome; Metabolomics; Middle Aged; Ornithine; Risk Factors; ROC Curve; SARS-CoV-2; Severity of Illness Index; Tryptophan | 2021 |
Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Apoptosis; Autopsy; Brain; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung; Middle Aged; Myocardium; Prospective Studies; Quinolinic Acid; Severity of Illness Index; Tryptophan | 2022 |
Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia.
Topics: Glycogen Synthase Kinase 3; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Induced Pluripotent Stem Cells; Inflammation; Kynurenine; Lithium; Microglia; Tryptophan | 2022 |
A prospective study of pre-diagnostic circulating tryptophan and kynurenine, and the kynurenine/tryptophan ratio and risk of glioma.
Topics: Case-Control Studies; Follow-Up Studies; Glioma; Humans; Kynurenine; Prospective Studies; Tryptophan; Tumor Microenvironment | 2022 |
The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder.
Topics: Bipolar Disorder; Cognitive Dysfunction; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2022 |
Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2.
Topics: COVID-19; Humans; Kynurenine; Prognosis; SARS-CoV-2; Tryptophan | 2022 |
Imaging of cerebral tryptophan metabolism using 7-[
Topics: Animals; Disease Models, Animal; Fluorine Radioisotopes; Hippocampus; Kynurenine; Male; Melatonin; Oxidopamine; Parkinson Disease; Pineal Gland; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Long-Evans; Serotonin; Tryptophan | 2022 |
Alterations in Kynurenine and NAD
Topics: Colitis; Humans; Inflammatory Bowel Diseases; Infliximab; Kynurenine; Metabolic Networks and Pathways; Nicotinamide N-Methyltransferase; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, Nicotinic; Tryptophan | 2021 |
T cell fat catabolism: A novel target for kynurenine?
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; T-Lymphocytes; Tryptophan | 2022 |
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Dioxygenases; Fibroblasts; Inflammation; Kynurenine; Rats; Synovial Membrane; Synoviocytes; Tryptophan; Tryptophan Oxygenase | 2022 |
The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites.
Topics: Adult; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gastrectomy; Gastric Bypass; Glycated Hemoglobin; Humans; Kynurenine; Longitudinal Studies; Male; Middle Aged; Obesity; Prospective Studies; Time Factors; Treatment Outcome; Tryptophan; Xanthurenates | 2022 |
Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes.
Topics: Aedes; Animals; Culex; Female; Homeostasis; Kynurenine; Mosquito Vectors; Tryptophan | 2022 |
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study.
Topics: C-Reactive Protein; Depression; Humans; Indoles; Inflammation; Kynurenine; Obesity; Tryptophan | 2022 |
Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV.
Topics: Aged; Cross-Sectional Studies; Dysbiosis; HIV Infections; Humans; Kynurenine; Middle Aged; Pilot Projects; Tandem Mass Spectrometry; Tryptophan | 2022 |
Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity.
Topics: Adipose Tissue; Adolescent; Body Mass Index; Cardiometabolic Risk Factors; Child; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Metabolic Diseases; Metabolic Networks and Pathways; Obesity, Morbid; Pediatric Obesity; Prospective Studies; Serotonin; Tryptophan | 2022 |
Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy.
Topics: Cytokines; Depression; Female; Humans; Kynurenine; Neuroinflammatory Diseases; Pregnancy; Tryptophan | 2022 |
Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation.
Topics: Gastrointestinal Microbiome; HIV; HIV Infections; Humans; Intra-Abdominal Fat; Kynurenine; Tryptophan | 2022 |
Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms.
Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Kynurenine; Rats; Seizures; Spasm; Spasms, Infantile; Tryptophan | 2022 |
Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
Topics: Adult; Aged; COVID-19; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Picolinic Acids; Prognosis; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2022 |
The Kynurenine/Tryptophan Ratio Is a Sensitive Biomarker for the Diagnosis of Pediatric Tuberculosis Among Indian Children.
Topics: Biomarkers; Child; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Longitudinal Studies; Metabolome; Prospective Studies; ROC Curve; Transcriptome; Tryptophan; Tuberculosis, Pulmonary | 2021 |
Blood versus cerebrospinal fluid: Kynurenine pathway metabolites in depression.
Topics: Depression; Kynurenine; Tryptophan | 2022 |
Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L.
Topics: Animals; Cannabis; Humans; Kynurenic Acid; Kynurenine; Neurotransmitter Agents; Tryptophan | 2022 |
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever.
Topics: Case-Control Studies; Familial Mediterranean Fever; Humans; Inflammation; Kynurenine; Tryptophan | 2023 |
Increasing the bioactivity of kynurenine by ultraviolet irradiation via resonance energy transfer in vitro.
Topics: Energy Transfer; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Topics: Amino Acid Transport System y+; Ferroptosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Signal Transduction; Tryptophan | 2022 |
Editorial: Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2022 |
Altered tryptophan metabolism in patients with recurrent functional abdominal pain.
Topics: Abdominal Pain; Chromatography, Liquid; Humans; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2022 |
Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites.
Topics: Chromatography, Liquid; Humans; Inflammation; Kynurenine; Nitric Oxide; Pilot Projects; Pterins; Tandem Mass Spectrometry; Tryptophan | 2022 |
Evaluation of Metabolic Changes in Acute Intermittent Porphyria Patients by Targeted Metabolomics.
Topics: Aminolevulinic Acid; Chromatography, Liquid; Humans; Kynurenine; Metabolomics; Porphyria, Acute Intermittent; Succinic Acid; Tandem Mass Spectrometry; Tryptophan | 2022 |
Urinary metabolomics identified metabolic disturbance associated with polycystic ovary syndrome.
Topics: Female; Humans; Kynurenine; Metabolome; Metabolomics; Polycystic Ovary Syndrome; Tryptophan | 2022 |
Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Kynurenine; Tryptophan | 2022 |
Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Receptors, Aryl Hydrocarbon; Tryptophan | 2022 |
Non-Invasive, Topical Sampling of Potential, Low-Molecular Weight, Skin Cancer Biomarkers: A Study on Healthy Volunteers.
Topics: Biomarkers; Biomarkers, Tumor; Healthy Volunteers; Humans; Kynurenine; Molecular Weight; Phenylalanine; Skin Neoplasms; Tryptophan; Tyrosine | 2022 |
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers; Depressive Disorder, Major; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Norepinephrine; Serotonin; Tryptophan; Vanilmandelic Acid | 2022 |
Tryptophan regulates
Topics: Animals; Drosophila melanogaster; Fat Body; Kynurenine; Malpighian Tubules; Tryptophan; Zinc | 2022 |
Unstability of cinnabarinic acid, an endogenous metabolite of tryptophan, under situations mimicking physiological conditions.
Topics: Imines; Kynurenine; Oxazines; Quinones; Receptors, Aryl Hydrocarbon; Tryptophan | 2022 |
Effects of pharmacological treatment on metabolomic alterations in animal models of depression.
Topics: Animals; Depression; Glucose; Inositol; Kynurenine; Lactic Acid; Models, Animal; Serotonin; Tryptophan | 2022 |
Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases.
Topics: Anti-Inflammatory Agents; Antidepressive Agents; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Molecular Docking Simulation; Salicylates; Serotonin; Tryptophan | 2022 |
Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh.
Topics: Adult; Bangladesh; Chromatography, Liquid; Humans; Kynurenine; Malnutrition; Tandem Mass Spectrometry; Tryptophan | 2022 |
Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Core Binding Factor Alpha 1 Subunit; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, Aryl Hydrocarbon; Tryptophan; Vascular Calcification | 2022 |
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
Topics: Behcet Syndrome; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives.
Topics: Autism Spectrum Disorder; Autistic Disorder; Humans; Kynurenic Acid; Kynurenine; Phenotype; Tryptophan | 2023 |
Topics: Animals; Cognition; Diet; Dysbiosis; Gastrointestinal Microbiome; Glutamic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Tryptophan | 2022 |
ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1A1; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Kynurenine; Liver Neoplasms; Tryptophan; Tumor Microenvironment | 2022 |
Expanding the Therapeutic World of Tryptophan Metabolism.
Topics: Amino Acids; Humans; Kynurenine; Metabolism; Tryptophan | 2022 |
Tryptophan oxidation in young children with environmental enteric dysfunction classified by the lactulose rhamnose ratio.
Topics: Biomarkers; Child; Child, Preschool; Humans; Kynurenine; Lactulose; Rhamnose; Tryptophan | 2022 |
Kynurenine produced by tryptophan 2,3-dioxygenase metabolism promotes glioma progression through an aryl hydrocarbon receptor-dependent signaling pathway.
Topics: Animals; Dioxygenases; Glioma; Kynurenine; Mice; Phosphatidylinositol 3-Kinases; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2022 |
Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy.
Topics: Adult; Anti-Retroviral Agents; HIV Infections; Humans; Kynurenine; RNA; Tryptophan; Tuberculosis | 2022 |
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Topics: Animals; Dendritic Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Signal Transduction; Tryptophan | 2022 |
Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19.
Topics: Biomarkers; Chromatography, Liquid; COVID-19; Humans; Inflammation; Kynurenine; Metabolomics; SARS-CoV-2; Tandem Mass Spectrometry; Tryptophan | 2022 |
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
Topics: Cross-Sectional Studies; Female; Humans; Kynurenic Acid; Kynurenine; Polycystic Ovary Syndrome; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
Targeted metabolomics suggests a probable role of the FTO gene in the kynurenine pathway in prediabetes.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Female; Genome-Wide Association Study; Genotype; Humans; Kynurenine; Male; Metabolomics; Prediabetic State; Tryptophan | 2022 |
The Cytokines CXCL10 and CCL2 and the Kynurenine Metabolite Anthranilic Acid Accurately Predict Patients at Risk of Developing Dengue With Warning Signs.
Topics: Chemokine CCL2; Chemokine CXCL10; Cytokines; Humans; Interferon-gamma; Interleukin-18; Kynurenine; Severe Dengue; Tryptophan | 2022 |
Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis.
Topics: Biomarkers; Dermatomyositis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2022 |
Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress.
Topics: Anxiety; Biomarkers; COVID-19; Depression; Humans; Kynurenic Acid; Kynurenine; Survivors; Tryptophan | 2022 |
The IDOze Study: The Link Between Sleep Disruption and Tryptophan-Kynurenine Pathway Activation in Women With Human Immunodeficiency Virus.
Topics: Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; RNA; Sleep; Tryptophan | 2022 |
Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation.
Topics: COVID-19; Cross-Sectional Studies; Cytokines; Disease Progression; Female; Humans; Kynurenine; Male; Retrospective Studies; SARS-CoV-2; Severity of Illness Index; Tryptophan | 2022 |
Kynurenines in polycystic kidney disease.
Topics: Adult; Child; Disease Progression; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kynurenine; Polycystic Kidney, Autosomal Dominant; Tryptophan | 2023 |
Validation of a liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantification of tryptophan and 10 key metabolites of the kynurenine pathway in plasma and urine: Application to a cohort of acute kidney injury patients.
Topics: Acute Kidney Injury; Chromatography, Liquid; Humans; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2022 |
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease.
Topics: Asparagine; Biomarkers; Community-Acquired Infections; Convalescence; Humans; Kynurenine; Pneumonia; Pulmonary Disease, Chronic Obstructive; Threonine; Tryptophan | 2022 |
Blast-related traumatic brain injury is mediated by the kynurenine pathway.
Topics: Animals; Benserazide; Brain Injuries, Traumatic; Kynurenine; Kynurenine 3-Monooxygenase; Tryptophan | 2022 |
Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study.
Topics: Calcium; Child; Child Health; Cross-Sectional Studies; Depression; Docosahexaenoic Acids; Eicosapentaenoic Acid; Female; Humans; Isoflavones; Japan; Kynurenic Acid; Kynurenine; Pregnancy; Pregnancy Complications; Prevalence; Quinolinic Acids; Serotonin; Surveys and Questionnaires; Tobacco Smoke Pollution; Tryptophan; Vitamin D | 2022 |
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa.
Topics: Chromatography, Liquid; Epidermolysis Bullosa Dystrophica; Fibrosis; Glutamates; Glutamine; Humans; Inflammation; Kynurenine; Malnutrition; Phenylalanine; Succinates; Tandem Mass Spectrometry; Tryptophan; Tyrosine | 2022 |
Resveratrol Alleviating the Ovarian Function Under Oxidative Stress by Alternating Microbiota Related Tryptophan-Kynurenine Pathway.
Topics: Animals; Female; Kynurenine; Microbiota; NF-E2-Related Factor 2; Oxidative Stress; Resveratrol; Sirtuin 1; Tryptophan; Tumor Suppressor Protein p53 | 2022 |
Kynurenine-3-monooxygenase expression is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-stimulated insulin secretion.
Topics: Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Kynurenine; Kynurenine 3-Monooxygenase; Morpholinos; Rats; Rats, Wistar; Tryptophan | 2022 |
A sensitive UPLC-MS/MS method for the simultaneous determination of the metabolites in the tryptophan pathway in rat plasma.
Topics: Acute Kidney Injury; Animals; Biomarkers; Chromatography, High Pressure Liquid; Chromatography, Liquid; Hydroxyindoleacetic Acid; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Rats; Tandem Mass Spectrometry; TRPM Cation Channels; Tryptophan | 2022 |
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Neopterin; Quinolinic Acid; Substance Withdrawal Syndrome; Tryptophan | 2022 |
Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway.
Topics: Animals; Female; Humans; Hypertension; Ischemia; Kidney; Kynurenine; Mice; Nephrectomy; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Tryptophan; Vascular Endothelial Growth Factor Receptor-1 | 2022 |
Altered Tryptophan Metabolism on the Kynurenine Pathway in Depressive Patients with Small Intestinal Bacterial Overgrowth.
Topics: Chromatography, Liquid; Humans; Kynurenic Acid; Kynurenine; Rifaximin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Cytokines; Depression; Estrogens; Interleukin-10; Isoflavones; Kynurenine; Lipopolysaccharides; Mice; Neuroinflammatory Diseases; Neuronal Plasticity; NF-kappa B; Serotonin; Sucrose; Synaptophysin; Toll-Like Receptor 4; Tryptophan; Tumor Necrosis Factor-alpha | 2022 |
Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth.
Topics: Animals; Carbidopa; Indoleamine-Pyrrole 2,3,-Dioxygenase; Janus Kinases; Kynurenine; Mice; Mice, Nude; Pancreatic Neoplasms; Receptors, Aryl Hydrocarbon; Signal Transduction; STAT Transcription Factors; Tryptophan | 2022 |
Tryptophan: Its Metabolism along the Kynurenine, Serotonin, and Indole Pathway in Malignant Melanoma.
Topics: Humans; Indoles; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Serotonin; Skin Neoplasms; Tryptophan | 2022 |
Dynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy.
Topics: Carcinoma, Non-Small-Cell Lung; Chemoradiotherapy; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Tryptophan | 2022 |
Indoleamine 2,3-dioxygenase gene expression and kynurenine to tryptophan ratio correlation with nasopharyngeal carcinoma progression and survival.
Topics: Cytokines; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-10; Interleukin-6; Kynurenine; Leukocytes, Mononuclear; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; RNA, Messenger; Tryptophan | 2022 |
Elevated Kynurenine Levels in Patients with Primary Sjögren's Syndrome.
Topics: C-Reactive Protein; Chromatography, Liquid; Humans; Kynurenine; Sjogren's Syndrome; Tryptophan | 2023 |
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.
Topics: Biomarkers; Chromatography, Liquid; COVID-19; Humans; Kynurenine; Mass Spectrometry; Prognosis; Serotonin; Tryptophan | 2022 |
A combination of neuroimaging and plasma metabolomic analysis suggests inflammation is associated with white matter structural connectivity in major depressive disorder.
Topics: Brain; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Lysophosphatidylcholines; Magnetic Resonance Imaging; Neuroimaging; Tryptophan; White Matter | 2022 |
Binge-like mephedrone treatment induces memory impairment concomitant with brain kynurenic acid reduction in mice.
Topics: Adolescent; Animals; Humans; Kynurenic Acid; Kynurenine; Methamphetamine; Mice; Transaminases; Tryptophan | 2022 |
Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids.
Topics: Animals; Brain-Gut Axis; Cytokines; Depression; Fatty Acids, Volatile; Kynurenine; Rats; Serotonin; Sucrose; Tryptophan; Vascular Depression | 2022 |
Simultaneous determination of serum tryptophan metabolites in an older Chinese population.
Topics: Chromatography, High Pressure Liquid; East Asian People; Humans; Kynurenic Acid; Kynurenine; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2023 |
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Lymnaea; Quinolinic Acid; Tryptophan | 2022 |
Pancancer Analysis of Revealed
Topics: B7 Antigens; Biomarkers, Tumor; DNA; Humans; Immunotherapy; Kynurenine; Methyltransferases; Microsatellite Instability; Neoplasms; Prognosis; Tryptophan; Tryptophan Oxygenase | 2022 |
The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.
Topics: Actins; beta Catenin; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Environmental Pollutants; Humans; Kynurenine; Ligands; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA; Tryptophan; Wnt Signaling Pathway | 2022 |
Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway.
Topics: Animals; Biological Factors; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NAD; Nicotinamide N-Methyltransferase; Receptors, Aryl Hydrocarbon; RNA, Messenger; Severity of Illness Index; Tryptophan | 2022 |
Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism.
Topics: Animals; Anxiety; Behavior, Animal; Female; Kynurenine; Mice; Pregnancy; Serotonin; Tryptophan | 2022 |
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan | 2022 |
IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression.
Topics: Animals; Depression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; Tryptophan | 2022 |
Kynurenine serves as useful biomarker in acute, Long- and Post-COVID-19 diagnostics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; COVID-19; COVID-19 Testing; Humans; Interleukin-6; Kynurenine; Middle Aged; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Tryptophan; Young Adult | 2022 |
Label-free tumor cell screening based on IDO1-mediated tryptophan metabolism at single cell level.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Neoplasms; Oxidation-Reduction; Tryptophan; Tryptophan Oxygenase | 2022 |
Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease.
Topics: Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Parkinson Disease; Polymorphism, Single Nucleotide; Tryptophan | 2022 |
Activation of the kynurenine-aryl hydrocarbon receptor axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stromal cells in osteoarthritis rats.
Topics: Animals; Arthritis, Rheumatoid; Cell Differentiation; Chondrogenesis; Humans; Kynurenine; Ligands; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Osteoarthritis; Rats; Receptors, Aryl Hydrocarbon; Tryptophan; Umbilical Cord | 2023 |
Tryptophan and Kynurenine Pathway Metabolites and Psychoneurological Symptoms Among Breast Cancer Survivors.
Topics: Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Female; Humans; Kynurenine; Tryptophan | 2023 |
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Ethanol; Kynurenine; Ligands; Lipid Metabolism; Liver; Mice; Phospholipids; Protein Phosphatase 2; Receptors, Aryl Hydrocarbon; Tryptophan | 2022 |
Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults.
Topics: Acute-Phase Reaction; Adult; Biomarkers; C-Reactive Protein; Chemokine CXCL10; Cytokines; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Interleukin-10; Interleukin-6; Kynurenine; Leukocytes, Mononuclear; Lipopolysaccharides; Neopterin; Receptors, Aryl Hydrocarbon; RNA, Ribosomal, 16S; Tryptophan; Tumor Necrosis Factor-alpha | 2022 |
The curious case of tryptophan in pregnancy.
Topics: Animals; Female; Humans; Kynurenine; Mice; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Tryptophan; Vascular Endothelial Growth Factor Receptor-1 | 2022 |
Human impact on the recent population history of the elusive European wildcat inferred from whole genome data.
Topics: Animals; Anthropogenic Effects; Cats; DNA, Mitochondrial; Humans; Kynurenine; Serotonin; Tryptophan | 2022 |
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.
Topics: Ammonia; Animals; Bile Acids and Salts; Bile Ducts; Brain; Choline; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hyperammonemia; Kynurenine; Liver Diseases; Mice; Microglia; Neuroinflammatory Diseases; Rats; Taurine; Tryptophan | 2022 |
Saliva metabolomic profile of COVID-19 patients associates with disease severity.
Topics: Aminolevulinic Acid; Biomarkers; C-Reactive Protein; Chromatography, Liquid; COVID-19; Humans; Kynurenine; Linoleic Acid; Metabolomics; Saliva; SARS-CoV-2; Severity of Illness Index; Sphingosine; Tandem Mass Spectrometry; Tryptophan | 2022 |
Alteration of the kynurenine pathway is inversely associated with the humoral immune response in patients with SARS-CoV-2.
Topics: COVID-19; Humans; Immunity, Humoral; Kynurenine; SARS-CoV-2; Tryptophan | 2022 |
Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis.
Topics: Animals; Cell Proliferation; Endothelial Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Myocytes, Cardiac; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Vascular Endothelial Growth Factor A | 2022 |
Topics: Animals; Catalytic Domain; Drosophila; Drosophila melanogaster; Drosophila Proteins; Kynurenine; Male; Memory, Long-Term; Mutation; Tryptophan | 2022 |
Tryptophan Modulatory Role in European Seabass (
Topics: Animal Feed; Animals; Bass; Disease Resistance; Hydrocortisone; Inflammation; Kynurenine; Membrane Glycoproteins; Tryptophan | 2022 |
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
The Tryptophan Catabolite or Kynurenine Pathway's Role in Major Depression.
Topics: Depression; Depressive Disorder, Major; Humans; Kynurenine; Tryptophan | 2022 |
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model.
Topics: Animals; Depression; Disease Models, Animal; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Mice; Tryptophan | 2022 |
High performance liquid chromatography-tandem mass spectrometry quantification of tryptophan metabolites in human serum and stool - Application to clinical cohorts in Inflammatory Bowel Diseases.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Inflammatory Bowel Diseases; Kynurenine; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation.
Topics: Cell Survival; Diethylhexyl Phthalate; Environmental Exposure; Environmental Pollutants; Female; Humans; Kynurenine; Large Neutral Amino Acid-Transporter 1; Leiomyoma; Phthalic Acids; Receptors, Aryl Hydrocarbon; Tryptophan | 2022 |
Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE.
Topics: Cognitive Dysfunction; Humans; Interferons; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Quinolinic Acid; Tryptophan | 2022 |
The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Tryptophan; Tryptophan Oxygenase | 2023 |
Dysregulation of tryptophan metabolism and distortion of cell signaling after oral exposure to ethanol and Kynurenic acid.
Topics: Adult; Animals; Ethanol; Humans; Kynurenic Acid; Kynurenine; Mice; Signal Transduction; Tryptophan | 2023 |
Aberrant tryptophan metabolism leads to unfavorable outcomes in lenalidomide-treated myeloma patients.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lenalidomide; Multiple Myeloma; Tryptophan | 2023 |
Differential Levels of Tryptophan-Kynurenine Pathway Metabolites in the Hippocampus, Anterior Temporal Lobe, and Neocortex in an Animal Model of Temporal Lobe Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kynurenic Acid; Kynurenine; Neocortex; Rats; Temporal Lobe; Tryptophan | 2022 |
Alterations in the Kynurenine-Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis.
Topics: COVID-19; Humans; Kynurenine; Lipids; Renal Dialysis; Tryptophan | 2022 |
Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy.
Topics: 5-Hydroxytryptophan; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Hydroxyindoleacetic Acid; Infant; Kynurenine; Pregnancy; Reproducibility of Results; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2023 |
The prevalence and the effect of interferon -γ in the comorbidity of rheumatoid arthritis and depression.
Topics: Animals; Arthritis, Rheumatoid; Comorbidity; Depression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Mice; Prevalence; Tryptophan | 2023 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic Acid; Kynurenine; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
Tryptophan metabolism can modulate immunologic tolerance in primitive vertebrate lamprey via IDO-kynurenine-AHR pathway.
Topics: Animals; Immune Tolerance; Kynurenine; Receptors, Aryl Hydrocarbon; Tryptophan; Vertebrates | 2023 |
Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition; Humans; Kynurenine; Longevity; Tryptophan | 2023 |
Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Memory Disorders; NAD; Obesity; Rats; Tryptophan | 2023 |
Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum.
Topics: Amino Acids; Hepatocytes; Humans; Kynurenine; Liver; Liver Cirrhosis; NAD; Non-alcoholic Fatty Liver Disease; Palmitates; Palmitic Acid; Tryptophan | 2023 |
Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress.
Topics: Adenosine Triphosphate; Animals; Cognitive Dysfunction; Hippocampus; Kynurenine; Male; Rats; Rats, Wistar; Tryptophan | 2023 |
Tryptophan catabolites and depression in the general population: results from the Gutenberg Health Study.
Topics: Biomarkers; C-Reactive Protein; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Tryptophan | 2023 |
The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors.
Topics: Delirium; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2023 |
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.
Topics: Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Inflammation; Interferon-gamma; Kynurenine; Lung Neoplasms; NAD; Neopterin; Tryptophan | 2023 |
Associations of Parameters of the Tryptophan-Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients.
Topics: Cardiovascular Diseases; Cross-Sectional Studies; Heart Disease Risk Factors; Humans; Hypertension; Kynurenine; Risk Factors; Tryptophan | 2023 |
Topics: Anorexia Nervosa; Binge-Eating Disorder; Bulimia Nervosa; DNA Methylation; Feeding and Eating Disorders; Humans; Kynurenine; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2023 |
Impaired kynurenine metabolism in patients with primary Sjögren's syndrome.
Topics: Chromatography, Liquid; Humans; Inflammation; Kynurenine; Sjogren's Syndrome; Tandem Mass Spectrometry; Tryptophan | 2023 |
Citrulline and kynurenine to tryptophan ratio: potential EED (environmental enteric dysfunction) biomarkers in acute watery diarrhea among children in Bangladesh.
Topics: Bangladesh; Biomarkers; Child, Preschool; Citrulline; Cross-Sectional Studies; Diarrhea; Humans; Infant; Kynurenine; Male; Tryptophan | 2023 |
Decreased kynurenine in cerebrospinal fluid and potential role in neuromyelitis optica spectrum disorder.
Topics: Aquaporin 4; Autoantibodies; Humans; Immunoglobulin G; Kynurenine; Neuromyelitis Optica; Pilot Projects; Tandem Mass Spectrometry; Tryptophan | 2023 |
Quantitation of tryptophan and kynurenine in human plasma using 4-vinylphenylboronic acid column by capillary electrochromatography coupled with mass spectrometry.
Topics: Capillary Electrochromatography; Humans; Kynurenine; Tandem Mass Spectrometry; Tryptophan | 2023 |
Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section.
Topics: Cesarean Section; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Placenta; Pregnancy; RNA, Messenger; Tryptophan; Tryptophan Oxygenase | 2023 |
Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress.
Topics: Animals; Brain; Inflammasomes; Kynurenine; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Tryptophan | 2023 |
Diversity-Oriented Biosynthesis Yields l-Kynurenine Derivative-Based Neurological Drug Candidate Collection.
Topics: Dioxygenases; Kynurenine; Tryptophan | 2023 |
DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.
Topics: Brain; Colitis; Gastrointestinal Microbiome; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; RNA, Ribosomal, 16S; Tryptophan | 2023 |
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.
Topics: Animals; Brain; Colitis; Gastrointestinal Microbiome; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammatory Bowel Diseases; Kynurenine; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Tryptophan; Tryptophan Oxygenase | 2022 |
PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1.
Topics: Animals; Antidepressive Agents; Depression; Dioxygenases; Disease Models, Animal; HMGB1 Protein; Inflammasomes; Kynurenine; NLR Family, Pyrin Domain-Containing 3 Protein; Proprotein Convertase 9; Rats; Rats, Wistar; Stress, Psychological; Toll-Like Receptor 4; Tryptophan | 2023 |
Resultant inward imbalanced seeding force (RIISF)-induced concave gold nanostar (CAuNS) for non-enzymatic electrocatalytic detection of serotonin and Kynurenine in human serum.
Topics: Biosensing Techniques; Carbon; Electrochemical Techniques; Electrodes; Gold; Humans; Kynurenine; Serotonin; Tryptophan | 2023 |
Simultaneous measurement of kynurenine metabolites and explorative metabolomics using liquid chromatography-mass spectrometry: A novel accurate method applied to serum and plasma samples from a large healthy cohort.
Topics: Chromatography, Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2023 |
Cognitive and hippocampal effects of adult male mice exposure to environmentally relevant doses of phthalates.
Topics: Animals; Cognition; Diethylhexyl Phthalate; Endocrine Disruptors; Hippocampus; Kynurenine; Male; Mice; Mice, Inbred C57BL; Phthalic Acids; Tryptophan | 2023 |
A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations.
Topics: Biomarkers; Diet, Vegetarian; Female; Humans; Inflammation; Kynurenine; Riboflavin; Tryptophan | 2023 |
Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor.
Topics: Animals; Chorionic Gonadotropin; Epiregulin; Humans; Interleukin-4; Kynurenine; L-Amino Acid Oxidase; Mammals; Receptors, Aryl Hydrocarbon; Tryptophan | 2023 |
Beneficial Effect of Increased Tryptophan Intake on Its Metabolism and Mental State of the Elderly.
Topics: Aged; Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Tryptophan | 2023 |
Rifaximin ameliorates depression-like behaviour in chronic unpredictable mild stress rats by regulating intestinal microbiota and hippocampal tryptophan metabolism.
Topics: Animals; Depression; Gastrointestinal Microbiome; Hippocampus; Kynurenine; Rats; Rifaximin; Serotonin; Stress, Psychological; Tryptophan | 2023 |
Interleukin-6 promotes skeletal muscle catabolism by activating tryptophan-indoleamine 2,3-dioxygenase 1-kynurenine pathway during intra-abdominal sepsis.
Topics: Animals; Cytokines; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenine; Lipopolysaccharides; Mice; Muscle, Skeletal; Sepsis; Tryptophan | 2023 |
Effect of whole foods on the microbial production of tryptophan-derived aryl hydrocarbon receptor agonists in growing pigs.
Topics: Animals; Indoles; Kynurenine; Receptors, Aryl Hydrocarbon; Skatole; Swine; Tryptophan | 2023 |
Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome.
Topics: Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Kynurenic Acid; Kynurenine; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2023 |
Differential Expression Patterns of Indoleamine 2,3-Dioxygenase 1 and Other Tryptophan and Arginine Catabolic Pathway Genes in Dengue Correlate with Clinical Severity-Pilot Study Results.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Pilot Projects; Severe Dengue; Tryptophan | 2023 |
Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder.
Topics: Depressive Disorder, Major; Dioxygenases; Humans; Inflammation; Kynurenine; Quality of Life; Tryptophan | 2023 |
Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids.
Topics: Adult; Amino Acids, Neutral; Depression; Diet; Humans; Kynurenine; Serotonin; Tryptophan | 2023 |
[Diagnoses and new therapeutic strategy focused on physiological alteration of tryptophan metabolism].
Topics: alpha7 Nicotinic Acetylcholine Receptor; Antidepressive Agents; Depressive Disorder, Major; Humans; Kynurenine; Serotonin; Tryptophan | 2023 |
Cluster headache and kynurenines.
Topics: Cluster Headache; Humans; Kynurenic Acid; Kynurenine; Neuroinflammatory Diseases; Tryptophan | 2023 |
Reduced Intake of Dietary Tryptophan Improves Beneficial Action of Budesonide in Patients with Lymphocytic Colitis and Mood Disorders.
Topics: Budesonide; Colitis, Lymphocytic; Diet; Humans; Hydroxyindoleacetic Acid; Kynurenine; Mood Disorders; Tryptophan | 2023 |
Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder.
Topics: Biomarkers; China; Depressive Disorder, Major; Dysbiosis; Gastrointestinal Microbiome; Humans; Kynurenine; Tryptophan | 2023 |
PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models.
Topics: Animals; Glioblastoma; Kynurenine; Mice; Oximes; Tryptophan | 2023 |
A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation.
Topics: Animals; C-Reactive Protein; Endothelial Progenitor Cells; Inflammation; Kynurenine; Lipopolysaccharides; Mice; Tryptophan | 2023 |
Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort.
Topics: Cross-Sectional Studies; Humans; Kynurenine; Osteoarthritis; Pain; Serotonin; Tryptophan | 2023 |
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocytosis; Male; Neopterin; Nervous System Diseases; Neuroinflammatory Diseases; Quinolinic Acid; Tryptophan | 2023 |
The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1.
Topics: Humans; Kynurenine; Melanoma; Oximes; Tryptophan | 2023 |
Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.
Topics: Fluorodeoxyglucose F18; Glucose; Humans; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Prospective Studies; Tryptophan | 2023 |
Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Kynurenine; Proteomics; Reactive Oxygen Species; Stomach Neoplasms; Tryptophan | 2023 |
Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.
Topics: Adult; HIV Infections; Humans; Inflammation; Kynurenine; Meningitis, Cryptococcal; Tryptophan; Tuberculosis, Meningeal | 2023 |
Breast cancer progression and kynurenine pathway enzymes are induced by hexachlorobenzene exposure in a Her2-positive model.
Topics: Cell Line, Tumor; Dioxygenases; Estrogen Receptor beta; Female; Hexachlorobenzene; Humans; Kynurenine; Pesticides; Receptors, Aryl Hydrocarbon; Triple Negative Breast Neoplasms; Tryptophan; Vascular Endothelial Growth Factor A | 2023 |
T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Pancreatic Neoplasms; Th17 Cells; Tryptophan | 2023 |
Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor.
Topics: 5-Hydroxytryptophan; Animals; Depression; Female; Kynurenine; Mice; Serotonin; Tryptophan; Whey Proteins | 2023 |
The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis.
Topics: Central Nervous System; Child; Humans; Interleukin-10; Interleukin-6; Kynurenine; Meningitis, Bacterial; Meningitis, Pneumococcal; Tryptophan | 2023 |
Neopterin and kynurenine in serum and urine as prognostic biomarkers in hospitalized patients with delta and omicron variant SARS-CoV-2 infection.
Topics: Biomarkers; COVID-19; Humans; Kynurenine; Neopterin; Oxygen; Prognosis; SARS-CoV-2; Tryptophan | 2023 |
Accelerated kynurenine pathway downregulates immune activation in patients with axial spondyloarthritis.
Topics: Cytokines; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Interleukin-23; Kynurenine; Tryptophan | 2023 |
The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC.
Topics: Adult; Biomarkers; Cognitive Dysfunction; COVID-19; Female; Humans; Kynurenine; Male; Middle Aged; Post-Acute COVID-19 Syndrome; Tryptophan | 2023 |
Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway.
Topics: CDX2 Transcription Factor; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Homeodomain Proteins; Humans; Interferon Regulatory Factor-3; Kynurenine; Metaplasia; Nucleotidyltransferases; Stomach Neoplasms; Tryptophan | 2023 |
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
Topics: Animals; HEK293 Cells; Humans; Kynurenine; Mice; Receptors, Aryl Hydrocarbon; T-Lymphocytes, Regulatory; Tryptophan | 2023 |
Plasma Levels of Kynurenine, Soluble OX40 and Mir-138-5p Are Associated With Tumor-infiltrating Lymphocytes in Colorectal Cancer: An Exploratory Study.
Topics: B7-H1 Antigen; Colorectal Neoplasms; Humans; Kynurenine; Lymphocytes; MicroRNAs; Tryptophan; Tumor Microenvironment | 2023 |
The association between inflammation and kynurenine pathway metabolites in electroconvulsive therapy for schizophrenia: Implications for clinical efficacy.
Topics: Electroconvulsive Therapy; Humans; Interleukin-18; Kynurenic Acid; Kynurenine; RNA, Messenger; Schizophrenia; Treatment Outcome; Tryptophan | 2023 |
Differential Lipidomics, Metabolomics and Immunological Analysis of Alcoholic and Non-Alcoholic Steatohepatitis in Mice.
Topics: Animals; Disease Models, Animal; Fatty Acids; Kynurenine; Lipidomics; Liver; Metabolomics; Mice; Non-alcoholic Fatty Liver Disease; Tryptophan | 2023 |
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.
Topics: Adolescent; Animals; Coleoptera; Depression; Gastrointestinal Microbiome; Humans; Kynurenine; Metabolomics; Mice; Microbiota; Quinolinic Acid; Serotonin; Sertraline; Tryptophan | 2023 |
Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance.
Topics: Animals; Estradiol; Female; Humans; Kynurenine; Lipopolysaccharides; Mammals; Ovary; Pregnancy; Tryptophan | 2023 |
Kynurenine pathway alteration in acute pancreatitis and its role as a biomarker of infected necrosis.
Topics: Acute Disease; Biomarkers; Endotoxins; HLA-DR Antigens; Humans; Kynurenine; Kynurenine 3-Monooxygenase; Leukocytes, Mononuclear; Necrosis; Pancreatitis, Acute Necrotizing; Procalcitonin; Tandem Mass Spectrometry; Tryptophan | 2023 |
Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers.
Topics: Adenocarcinoma; Female; Gastrointestinal Neoplasms; Humans; Kynurenine; Leukocytes, Mononuclear; Male; Obesity; Tryptophan | 2023 |
Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture.
Topics: Animals; Diethylhexyl Phthalate; Female; Kynurenine; Male; Mice; Mice, Inbred C57BL; Phthalic Acids; Tryptophan | 2023 |
High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism.
Topics: Animals; Colon; Diet, High-Fat; Gastrointestinal Microbiome; Humans; Kynurenine; Mice; Tryptophan | 2023 |
Relationship of tryptophan metabolites with the type and severity of multiple sclerosis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Mammals; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2023 |
The effect of inflammation, SARS-CoV-2 infection, age and mental health on serotonin, and kynurenine and catecholamine pathway metabolites.
Topics: COVID-19; Cross-Sectional Studies; Dopamine; Humans; Inflammation; Kynurenine; Mental Health; Phenylalanine; SARS-CoV-2; Serotonin; Tryptophan; Tyrosine | 2023 |
Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy.
Topics: Animals; Cardiomegaly; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mass Spectrometry; Mice; Tryptophan | 2023 |
The kynurenine pathway of tryptophan metabolism: a neglected therapeutic target of COVID-19 pathophysiology and immunotherapy.
Topics: COVID-19; Humans; Immunotherapy; Kynurenine; NAD; Poly(ADP-ribose) Polymerase Inhibitors; SARS-CoV-2; Tryptophan | 2023 |
Identification and characterization of tryptophan-kynurenine pathway-related genes involving lamprey (Lampetra japonica) innate immunity.
Topics: Animals; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lampreys; Tryptophan | 2023 |
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
Topics: Chromatography, Liquid; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukocytes, Mononuclear; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Tandem Mass Spectrometry; Tryptophan | 2023 |
Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study.
Topics: Biomarkers; Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenine; Periodontal Diseases; Smoking; Tryptophan | 2023 |
LC-MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples.
Topics: Chromatography, Liquid; Extraembryonic Membranes; Female; Humans; Kynurenic Acid; Kynurenine; Placenta; Pregnancy; Reproducibility of Results; Tandem Mass Spectrometry; Tryptophan; Umbilical Cord | 2023 |
Anxiety due to Long COVID is partially driven by activation of the tryptophan catabolite (TRYCAT) pathway.
Topics: Anxiety; COVID-19; Humans; Kynurenine; Post-Acute COVID-19 Syndrome; Tryptophan | 2023 |
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Colon; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenine; Putrescine; Swine; Transaminases; Tryptophan | 2023 |
The role of cytokines and Indolamine-2.3 dioxygenase in experiencing a psycho-neurological symptom cluster in hematological cancer patients: IL-1alpha, IL-1beta, IL-4, IL-6, TNF-alpha, kynurenine, and tryptophan.
Topics: Cytokines; Dioxygenases; Hematologic Neoplasms; Humans; Interleukin-4; Interleukin-6; Kynurenine; Neoplasms; Prospective Studies; Syndrome; Tryptophan; Tumor Necrosis Factor-alpha | 2023 |
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.
Topics: Female; Humans; Kynurenine; Leiomyoma; Mediator Complex; Mutation; Receptors, Aryl Hydrocarbon; Tryptophan; Tryptophan Oxygenase; Uterine Neoplasms | 2023 |
Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor.
Topics: Adipocytes; Epithelial Cells; Hormones; Humans; Kynurenine; Ligands; Receptors, Aryl Hydrocarbon; Triple Negative Breast Neoplasms; Tryptophan | 2023 |
Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Mice; Tryptophan | 2023 |
Treatment of ankylosing spondylitis with TNFα inhibitors does not affect serum levels of tryptophan metabolites.
Topics: Adult; Female; Humans; Immunologic Factors; Kynurenine; Male; Middle Aged; Serotonin; Spondylitis, Ankylosing; Tryptophan; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB.
Topics: Animals; Cell Line, Tumor; Female; Flame Retardants; Humans; Kynurenine; Male; Mice; Monoamine Oxidase; NF-kappa B; Organophosphates; Placenta; Pregnancy; Reactive Oxygen Species; Serotonin; Tryptophan | 2023 |
Liquid chromatography-tandem mass spectrometry based simultaneous quantification of tryptophan, serotonin and kynurenine pathway metabolites in tissues and cell culture systems.
Topics: Animals; Chromatography, Liquid; Dioxygenases; Kynurenine; Mice; Niacin; Reproducibility of Results; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2023 |
Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Follow-Up Studies; Humans; Kynurenine; Male; Risk Factors; Tryptophan | 2023 |
Upregulation of Indoleamine 2,3-Dioxygenase 1 in Tumor Cells and Tertiary Lymphoid Structures is a Hallmark of Inflamed Non-Small Cell Lung Cancer.
Topics: B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Neoplasms; Tertiary Lymphoid Structures; Tryptophan; Up-Regulation | 2023 |
Nordic Walking training in BungyPump form improves cognitive functions and physical performance and induces changes in amino acids and kynurenine profiles in older adults.
Topics: Amino Acids; Brain-Derived Neurotrophic Factor; Cognition; Fibronectins; Kynurenine; Nordic Walking; Phenylalanine; Physical Functional Performance; Tryptophan | 2023 |
Lower levels of the neuroprotective tryptophan metabolite, kynurenic acid, in users of estrogen contraceptives.
Topics: Contraceptives, Oral, Hormonal; Estrogens; Female; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Pyridoxine; Tryptophan; Vitamin B 6 | 2023 |
Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain; Corticosterone; Depressive Disorder, Major; Fluoxetine; Kynurenine; Mice; Organic Cation Transporter 2; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan | 2023 |
IDO-triggered swellable polymeric micelles for IDO inhibition and targeted cancer immunotherapy.
Topics: Drug Delivery Systems; Humans; Immunotherapy; Kynurenine; Micelles; Neoplasms; Tryptophan; Tumor Microenvironment | 2023 |
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Tryptophan | 2023 |
The possible role of quinolinic acid as a predictive marker in patients with SARS-CoV-2.
Topics: C-Reactive Protein; COVID-19; Humans; Kynurenine; Procalcitonin; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2023 |
Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics.
Topics: Breast Neoplasms; Cell Line; Chromatography, Liquid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tandem Mass Spectrometry; Tryptophan; Tryptophan Oxygenase | 2024 |
Differential Effects of Hypothermia and SZR72 on Cerebral Kynurenine and Kynurenic Acid in a Piglet Model of Hypoxic-Ischemic Encephalopathy.
Topics: Animals; Asphyxia; Hypothermia; Hypoxia-Ischemia, Brain; Kynurenic Acid; Kynurenine; Swine; Tryptophan | 2023 |
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia.
Topics: Case-Control Studies; Female; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Tryptophan | 2023 |
Preparation of
Topics: Cell Line, Tumor; Kynurenine; Positron-Emission Tomography; Radiopharmaceuticals; Tryptophan | 2023 |
Treatment of 95 post-Covid patients with SSRIs.
Topics: COVID-19; Fatigue Syndrome, Chronic; Humans; Kynurenine; Primary Dysautonomias; Selective Serotonin Reuptake Inhibitors; Tryptophan | 2023 |
Longitudinal associations of macronutrient and micronutrient intake with plasma kynurenines in colorectal cancer survivors up to 12 months posttreatment.
Topics: Eating; Humans; Kynurenic Acid; Kynurenine; Micronutrients; Neoplasms; Nutrients; Prospective Studies; Quality of Life; Survivors; Tryptophan | 2023 |
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Dioxygenases; Head and Neck Neoplasms; Humans; Immunologic Factors; Immunotherapy; Kynurenine; Leukocytes, Mononuclear; Lung Neoplasms; Mice; Receptors, Aryl Hydrocarbon; Squamous Cell Carcinoma of Head and Neck; Tryptophan; Tumor Microenvironment | 2023 |
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells.
Topics: Adenocarcinoma of Lung; B7-H1 Antigen; Humans; Kynurenine; Lung Neoplasms; RNA, Messenger; Tryptophan; Tumor Microenvironment | 2023 |
Cellular and molecular signatures of motherhood in the adult and ageing rat brain.
Topics: Animals; Brain; Female; Humans; Kynurenine; Phosphoproteins; Postpartum Period; Pregnancy; Rats; Tryptophan | 2023 |
Correlation between immune-related Tryptophan-Kynurenine pathway and severity of severe pneumonia and inflammation-related polyunsaturated fatty acids.
Topics: Arachidonic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Kynurenine; Linolenic Acids; Pneumonia; Tryptophan | 2023 |
N (1)-Fluoroalkyltryptophan Analogues: Synthesis and in vitro Study as Potential Substrates for Indoleamine 2,3-Dioxygenase.
Topics: | 2015 |