tryptophan and alpha-methyltryptophan, (l)-isomer

tryptophan has been researched along with alpha-methyltryptophan, (l)-isomer in 119 studies

Research

Studies (119)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (4.20)	18.7374
1990's	33 (27.73)	18.2507
2000's	50 (42.02)	29.6817
2010's	25 (21.01)	24.3611
2020's	6 (5.04)	2.80

Authors

Authors	Studies
Diksic, M; Grdisa, M; Takada, A	1
Missala, K; Montine, TJ; Sourkes, TL	2
Higginbottom, M; Kneen, C; Ratcliffe, GS	1
Sourkes, TL	2
Diksic, M; Sourkes, TL	1
Cady, SG; Sono, M	1
Chaly, T; Diksic, M	1
Diksic, M; Grdisa, M; Nagahiro, S	1
Crisma, M; Di Blasio, B; Fattorusso, R; Formaggio, F; Kamphuis, J; Kaptein, B; Maglio, O; Schoemaker, HE; Toniolo, C; Valle, G	1
Diksic, M; Tsuiki, K; Yamamoto, YL	1
Diksic, M; Grdisa, M; Tsuiki, K; Vanier, M; Worsley, K	1
Diksic, M; Grdisa, M; Nagahiro, S; Pappius, HM; Takada, A; Tsuiki, K	1
Hildebrand, JG; Novak, MG; Ribeiro, JM	1
Novak, MG; Rowley, WA	1
Bostock, RM; Gilchrist, DG; Kosuge, T; Silverstone, SE	1
Diksic, M; Mzengeza, S; Rajagopal, S; Venkatachalam, TK	1
Schmall, B; Shoaf, SE	1
Diksic, M; Grdisa, M	1
Diksic, M; Hamel, E; Ljubić-Thibal, V; Pujol, JF; Raison, S; Weissmann, D	1
Dong, W; Kreps, JA; Ponappa, T; Town, CD	1
Chakraborty, PK; Chugani, DC; Chugani, HT; Mangner, TJ; Muzik, O	1
Chakraborty, P; Chugani, DC; Chugani, HT; Mangner, T; Muzik, O	2
Benkelfat, C; Diksic, M; Leyton, M; Mzengeza, S; Nishizawa, S; Okazawa, H	1
Carson, R; Eckelman, W; Herscovitch, P; Higley, JD; Hommer, D; Linnoila, M; Schmall, B; Shoaf, SE; Williams, W	1
Canady, A; Chakraborty, PK; Chugani, DC; Chugani, HT; Mangner, TJ; Muzik, O; Shah, AK; Shah, JR	1
Blier, P; Diksic, M; Okazawa, H; Yamane, F	1
Balende, C; Bobillier, P; Gharib, A; Luxen, A; Plenevaux, A; Pujol, JF; Sarda, N; Weissmann, D	1
Benkelfat, C; Diksic, M; Leyton, M; Okazawa, H; Young, SN	1
Dyakonova, VE; Sakharov, DA; Schürmann, F	1
Benkelfat, C; Diksic, M; Leyton, M	2
Kokay, IC; Mercer, AR; Mitchell, CJ; Purnell, MT; Taylor, DJ	1
Carson, RE; Eckelman, WC; Herscovitch, P; Higley, JD; Hommer, D; Linnoila, M; Schmall, B; Shoaf, SE; Williams, WA	1
Benkelfat, C; Leyton, M; Young, SN	1
Hofmann, HA; Schildberger, K; Schoch, K; Stevenson, PA	1
Diksic, M; Mzengeza, S; Venkatachalam, TK	1
Chugani, DC; Chugani, HT	1
Diksic, M	2
Diksic, M; Takada, A; Tohyama, Y	1
Benkelfat, C; Blier, P; Diksic, M; Leyton, M; Mzengeza, S; Okazawa, H; Paris, J; Rosa, P; Young, SN	1
Diksic, M; Merid, MF; Tohyama, Y; Yamane, F	1
Diksic, M; Young, SN	1
Andermann, E; Andermann, F; Boling, W; Diksic, M; Dubeau, F; Fedi, M; Gross, DW; Nakai, A; Okazawa, H; Reutens, D; White, C	1
Diksic, M; Merid, MF; Takahashi, S; Tohyama, Y; Watanabe, A	1
Blier, P; Diksic, M; Fikre Merid, M; Tohyama, Y; Yamane, F	1
Behen, ME; Chakraborty, P; Chugani, DC; Chugani, HT; Juhász, C; Lee, J; Mangner, T; Muzik, O; Pfund, Z	1
Chanut, E; Labarthe, B; Nguyen-Legros, J; Trouvin, JH; Versaux-Botteri, C	1
Andermann, E; Andermann, F; Boling, W; Diksic, M; Dubeau, F; Fedi, M; Gross, DW; Nakai, A; Okazawa, H; Reutens, DC; White, C	1
Andermann, F; Bernasconi, A; Bernasconi, N; Diksic, M; Dubeau, F; Fedi, M; Kumakura, Y; Lisbona, R; Nakai, A; Natsume, J; Rosa, P; Soucy, JP	1
Asano, E; Chakraborty, PK; Chugani, DC; Chugani, HT; Juhász, C; Mangner, TJ; Muzik, O; Shah, A; Sood, S	1
Boivin, M; D'Souza, D; Diksic, M; Kersey, K; Kumakura, Y; Nakai, A; Rosa, P	1
Diksic, M; Mück-Seler, D; Pivac, N	1
SOURKES, TL; TOWNSEND, E	1
FLOSS, HG; GROEGER, D	1
MORAN, JF; SOURKES, TL	1
SANKOFF, I; SOURKES, TL	1
Boon, T; Colau, D; Parmentier, N; Pilotte, L; Stroobant, V; Théate, I; Uyttenhove, C; Van den Eynde, BJ	1
Schepers, K; Schumacher, TN	1
Benkelfat, C; Blier, P; Debonnel, G; Diksic, M; Ghadirian, N; Leyton, M; Mzengeza, S; Nakai, A; Okazawa, H; Rosa-Neto, P	1
Diksic, M; Sikirić, P; Tohyama, Y	1
Diksic, M; Nishizawa, S; Okazawa, H; Tsuchida, T; Yonekura, Y	1
Debonnel, G; Diksic, M; Hasegawa, S; Nguyen, KQ; Watanabe, A	1
Diksic, M; Hasegawa, S; Nguyen, KQ; Nishi, K; Watanabe, A	2
Dyakonova, V; Rillich, J; Schildberger, K; Stevenson, PA	1
Coleman, CM; Neckameyer, WS	1
Benkelfat, C; Diksic, M; Leyton, M; Mzengeza, S; Rosa-Neto, P	1
Asano, E; Chakraborty, PK; Chugani, DC; Chugani, HT; Juhász, C; Kagawa, K; Kupsky, WJ; Mangner, TJ; Muzik, O; Shah, A; Shah, J; Sood, S	1
Barger, G; Chakraborty, PK; Chugani, DC; Chugani, HT; Ergun, EL; Juhász, C; Kupsky, WJ; Mangner, TJ; Muzik, O; Shah, AK; Sloan, AE; Sood, S; Watson, C; Wu, D	1
Diksic, M; Gittos, M; Hasegawa, S; Kanemaru, K	1
Benkelfat, C; Diksic, M; Fiset, P; Kumakura, Y; Leyton, M; Nishikawa, M; Vogelzangs, N; Young, SN	1
Benkelfat, C; Diksic, M; Gravel, P; Leyton, M; Paquette, V; Rosa-Neto, P; Weston, F	1
Blomquist, G; Hammarlund-Udenaes, M; Hartvig, P; Långström, B; Lundquist, P	1
Benkelfat, C; Diksic, M; Leyton, M; Nishikawa, M; Sakai, Y; Young, SN	1
Diksic, M; Mück-Seler, D; Tohyama, Y	1
Beauregard, M; Benkelfat, C; Diksic, M; Gravel, P; Paquette, V; Perreau-Linck, E; Soucy, JP	1
Aghakhani, Y; Andermann, F; Bernasconi, A; Bernasconi, N; Diksic, M; Dubeau, F; Fedi, M; Kumakura, Y; Natsume, J; Nishikawa, M; Soualmi, L	1
Ganapathy, V; Hatanaka, T; Itagaki, S; Karunakaran, S; Munn, DH; Prasad, PD; Thangaraju, M; Umapathy, NS	1
Diksic, M; Frey, BN; Lubarsky, S; Rosa-Neto, P	1
Diksic, M; Hasegawa, S; Kanemaru, K; Nishi, K	1
Chugani, DC; Chugani, HT; Juhász, C; Kupsky, WJ; Muzik, O; Wakamoto, H	1
Charney, D; Diksic, M; Gill, K; Kumano, H; Negrete, J; Nishikawa, M; Palacios-Boix, J; Sakai, Y	1
Chakraborty, PK; Chugani, DC; Jahania, MS; Juhász, C; Khalaf, M; Lu, X; Mangner, TJ; Muzik, O; Peng, F; Soubani, AO	1
Diksic, M; Kanemaru, K; Nishi, K	1
Behen, ME; Chugani, HT; Juhász, C; Makki, MI; Muzik, O; Saporta, AS; Wilson, BJ	1
Diksic, M; Frey, BN; Nishikawa, M; Sakai, Y; Skelin, I	1
Balakrishnan, B; Chakraborty, PK; Chugani, DC; Dai, H; Janisse, J; Kannan, S; Muzik, O; Romero, R; Saadani-Makki, F	1
Benkelfat, C; Berney, A; Blier, P; Diksic, M; Gravel, P; Leyton, M; Nakai, A; Nordahl, TE; Okazawa, H; Pinard, G; Rosa Neto, P; Sibon, I; Sookman, D; Todorov, C	1
Diksic, M; Pivac, N	1
Asano, E; Chugani, HT; Juhász, C; Kumar, A; Kupsky, W; Sood, S	1
Chugani, DC	1
Asano, E; Chugani, HT; Kumar, A	1
Alkonyi, B; Chugani, DC; Chugani, HT; Juhász, C; Kupsky, WJ; Mittal, S; Muzik, O; Sood, S; Zitron, I	1
Gillis, BC; Johnson, N; Kamhi, JF; Muscedere, ML; Traniello, JF	1
Arseneault, L; Benkelfat, C; Booij, L; Diksic, M; Gravel, P; Lévesque, ML; Leyton, M; Tremblay, RE; Vitaro, F	1
Ali-Fehmi, R; Bandyopadhyay, S; Chakraborty, PK; Chugani, DC; Janabi, MZ; Juhász, C; Mangner, TJ; Mittal, S; Muzik, O; Nahleh, Z; Zitron, I	1
Alkonyi, B; Bahl, G; Barger, GR; Chakraborty, PK; Chugani, DC; Juhász, C; Kupsky, WJ; Mittal, S; Muzik, O; Robinette, NL	1
Barger, GR; Chakraborty, PK; Chugani, DC; Juhász, C; Kupsky, WJ; Mittal, S; Muzik, O	1
Diksic, M; Fikre-Merid, M; Skelin, I	1
Aubé, M; Diksic, M; Nishikawa, M; Sakai, Y	1
Benkelfat, C; Booij, L; Diksic, M; Gravel, P; Leyton, M; Pihl, RO; Regoli, M; Soucy, JP; Young, SN	1
Cumming, P	1
Moughan, PJ; Richardson, RK; Rutherfurd, SM	1
Gillies, RJ; Huang, X; Tian, H; Xiao, X	1
Bhutia, YD; Cao, S; Coothankandaswamy, V; Ganapathy, V; Ogura, J; Prasad, PD; Reynolds, CP; Singh, PK; Xu, Y; Yang, S	1
Barger, GR; Bosnyák, E; Juhász, C; Kamson, DO; Klinger, NV; Michelhaugh, SK; Mittal, S	1
Asano, E; Bagla, S; Chugani, DC; Chugani, HT; Cukovic, D; Dombkowski, AA; Luat, A; Sood, S	1
Chu, X; Gao, L; Hu, X; Kong, Q; Sun, R; Wang, Y; Wu, X; Zhou, S	1
Ahmadi, S; Bear, CE; Bozoky, Z; Di Paola, M; Du, K; Forman-Kay, J; Gonska, T; Ip, W; Lew, A; Li, M; Lloyd-Kuzik, A; Wu, YS; Xia, S	1
Bhutia, YD; Brown, TP; Ganapathy, V; Sikder, MOF; Sivaprakasam, S; Thangaraju, M	1
Avagliano, C; Cervenka, S; Erhardt, S; Häggkvist, J; Johnström, P; Kondrashov, M; Krasikova, R; Petukhov, M; Revunov, E; Schou, M; Tari, L; Tóth, M; Vazquez-Romero, A	1
Bhutia, YD; Cai, A; Chen, R; Chen, Z; Ganapathy, V; Kou, L; Li, C; Lin, X; Yao, Q; Zheng, H	1
Bhutia, YD; Ganapathy, V; Ramachandran, S; Sikder, MOF; Sivaprakasam, S; Wachtel, MW	1
De Plaen, E; Gyrd-Hansen, M; Hoffmann, D; Klaessens, S; Pilotte, L; Stroobant, V; Van den Eynde, BJ; Vigneron, N	1
Eleftheriadis, T; Filippidis, G; Liakopoulos, V; Pissas, G; Stefanidis, I	1

Reviews

9 review(s) available for tryptophan and alpha-methyltryptophan, (l)-isomer

Article	Year
Alpha-methyltryptophan as a therapeutic agent. Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:6 Topics: Animals; Depressive Disorder; Humans; Serotonin; Tryptophan	1991
Conversion of alpha-methyltryptophan to alpha-methylserotonin in vivo. New techniques for imaging serotonin. Advances in neurology, 1993, Volume: 60 Topics: Animals; Brain; Dogs; Rats; Serotonin; Serotonin Receptor Agonists; Tomography, Emission-Computed; Tryptophan; Tryptophan Hydroxylase	1993
Alpha-methyl-L-tryptophan as a tracer to study brain serotonergic system. Neurochemical research, 1995, Volume: 20, Issue:11 Topics: Animals; Brain; Functional Laterality; Humans; Linear Models; Radioactive Tracers; Serotonin; Tryptophan	1995
Pet studies of serotonin synthesis in the human brain. Advances in experimental medicine and biology, 1999, Volume: 467 Topics: Brain; Carbon Radioisotopes; Female; Humans; Male; Personality Disorders; Radiopharmaceuticals; Serotonin; Sex Characteristics; Tomography, Emission-Computed; Tryptophan	1999
PET: mapping of serotonin synthesis. Advances in neurology, 2000, Volume: 83 Topics: Adolescent; Brain; Child; Child, Preschool; Epilepsies, Partial; Female; Humans; Infant; Serotonin; Tomography, Emission-Computed; Tryptophan; Tuberous Sclerosis	2000
Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan. Journal of neurochemistry, 2001, Volume: 78, Issue:6 Topics: Animals; Autoradiography; Brain; Humans; Models, Neurological; Serotonin; Synaptic Transmission; Tomography, Emission-Computed; Tryptophan	2001
Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system. Journal of psychiatry & neuroscience : JPN, 2001, Volume: 26, Issue:4 Topics: Animals; Blood-Brain Barrier; Brain; Humans; Models, Neurological; Models, Theoretical; Receptors, Serotonin; Serotonin; Tryptophan	2001
α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions. Biomarkers in medicine, 2011, Volume: 5, Issue:5 Topics: Biomarkers; Brain; Epilepsy; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Positron-Emission Tomography; Serotonin; Tryptophan	2011
α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies. Biomarkers in medicine, 2011, Volume: 5, Issue:5 Topics: Biomarkers; Brain; Epilepsy; Humans; Positron-Emission Tomography; Tryptophan; Tuberous Sclerosis	2011

Trials

5 trial(s) available for tryptophan and alpha-methyltryptophan, (l)-isomer

Article	Year
Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:6 Topics: Adult; Brain; Caudate Nucleus; Cerebral Cortex; Feasibility Studies; Half-Life; Humans; Kinetics; Linear Models; Reference Values; Serotonin; Thalamus; Tomography, Emission-Computed; Tryptophan	1997
Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin. Neurology, 2001, Nov-13, Volume: 57, Issue:9 Topics: Adolescent; Adult; Carbon Radioisotopes; Electroencephalography; Epilepsies, Partial; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neocortex; Radiopharmaceuticals; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tryptophan	2001
Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy. Neurology, 2003, Mar-11, Volume: 60, Issue:5 Topics: Adolescent; Adult; Aged; Amygdala; Atrophy; Cerebral Cortex; Epilepsy, Temporal Lobe; Female; Glucose; Hippocampus; Humans; Kynurenine; Male; Middle Aged; Tomography, Emission-Computed; Tryptophan	2003
Stability of alpha-[11C]methyl-L-tryptophan brain trapping in healthy male volunteers. European journal of nuclear medicine and molecular imaging, 2005, Volume: 32, Issue:10 Topics: Adult; Brain; Brain Mapping; Humans; Male; Metabolic Clearance Rate; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Serotonin; Tryptophan	2005
Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity. Clinical nuclear medicine, 2012, Volume: 37, Issue:9 Topics: Adult; Aged; Biological Transport; Brain Neoplasms; Case-Control Studies; Cell Proliferation; Cerebral Cortex; Female; Glioma; Humans; Ki-67 Antigen; Kinetics; Male; Middle Aged; Positron-Emission Tomography; Tryptophan; Young Adult	2012

Other Studies

105 other study(ies) available for tryptophan and alpha-methyltryptophan, (l)-isomer

Article	Year
Blood-brain barrier transfer of L-Trp and alpha-MTrp in Li-treated rats. Neurochemistry international, 1992, Volume: 21, Issue:4 Topics: Animals; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Isoleucine; Leucine; Lithium; Rats; Tryptophan; Valine	1992
Alpha-methyltryptophan metabolism in rat pineal gland and brain. Journal of pineal research, 1992, Volume: 12, Issue:1 Topics: Animals; Brain; Chromatography, High Pressure Liquid; Male; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains; Serotonin; Tryptophan	1992
Rationally designed "dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists. Journal of medicinal chemistry, 1992, May-01, Volume: 35, Issue:9 Topics: Animals; Cerebral Cortex; Cholecystokinin; Drug Design; Male; Mice; Models, Molecular; Receptors, Cholecystokinin; Thermodynamics; Tryptophan	1992
Alpha-methylserotonin, a substitute transmitter for serotonergic neurons. Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:5 Topics: Animals; Brain; Hydroxyindoleacetic Acid; Male; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Subcellular Fractions; Synaptosomes; Tryptophan	1990
Autoradiographic measurement of the rate of serotonin synthesis in the rat brain. Advances in experimental medicine and biology, 1991, Volume: 294 Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Autoradiography; Biopterins; Brain; Brain Chemistry; Kinetics; Models, Biological; Oxygen; Rats; Serotonin; Tryptophan; Tryptophan Hydroxylase	1991
1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase. Archives of biochemistry and biophysics, 1991, Volume: 291, Issue:2 Topics: Alanine; Animals; Benzofurans; Binding, Competitive; Circular Dichroism; Ferric Compounds; Ferrous Compounds; Kinetics; Rabbits; Spectrophotometry; Tryptophan; Tryptophan Oxygenase	1991
Synthesis of "no-carrier-added" alpha-[11C]methyl-L-tryptophan. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1988, Volume: 29, Issue:3 Topics: Carbon Radioisotopes; Isotope Labeling; Tryptophan	1988
The regional rate of serotonin synthesis estimated by the alpha-methyl-tryptophan method in rat brain from a single time point. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:5 Topics: Animals; Autoradiography; Brain; Methods; Models, Biological; Rats; Rats, Wistar; Regression Analysis; Serotonin; Time Factors; Tissue Distribution; Tryptophan	1995
The preferred solid-state conformation of (alpha Me)Trp peptides. International journal of peptide and protein research, 1995, Volume: 45, Issue:1 Topics: Amino Acid Sequence; Dipeptides; Models, Molecular; Molecular Sequence Data; Protein Conformation; Stereoisomerism; Tryptophan; X-Ray Diffraction	1995
Effect of acute fluoxetine treatment on the brain serotonin synthesis as measured by the alpha-methyl-L-tryptophan autoradiographic method. Journal of neurochemistry, 1995, Volume: 65, Issue:1 Topics: Animals; Autoradiography; Brain; Fluoxetine; Male; Rats; Rats, Wistar; Serotonin; Tissue Distribution; Tryptophan	1995
Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis. Journal of neurochemistry, 1995, Volume: 64, Issue:2 Topics: Animals; Autoradiography; Brain; Female; In Vitro Techniques; Models, Neurological; Neurochemistry; Probenecid; Rats; Rats, Wistar; Serotonin; Tissue Distribution; Tryptophan	1995
Synthesis of serotonin in traumatized rat brain. Journal of neurochemistry, 1995, Volume: 64, Issue:3 Topics: Animals; Autoradiography; Brain; Brain Injuries; Cerebral Cortex; Freezing; Male; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Tryptophan; Wounds and Injuries	1995
5-hydroxytryptamine in the salivary glands of adult female Aedes aegypti and its role in regulation of salivation. The Journal of experimental biology, 1995, Volume: 198, Issue:Pt 1 Topics: Aedes; Animals; Female; Fluorescent Antibody Technique; Salivary Glands; Salivation; Serotonin; Tryptophan	1995
Serotonin depletion affects blood-feeding but not host-seeking ability in Aedes triseriatus (Diptera: Culicidae). Journal of medical entomology, 1994, Volume: 31, Issue:4 Topics: Aedes; alpha-Methyltyrosine; Animals; Behavior, Animal; Blood; Feeding Behavior; Female; Methyltyrosines; Rabbits; Serotonin; Tryptophan	1994
The 73-kb pIAA plasmid increases competitive fitness of Pseudomonas syringae subspecies savastanoi in oleander. Canadian journal of microbiology, 1993, Volume: 39, Issue:7 Topics: Biological Evolution; Drug Resistance, Microbial; Indoleacetic Acids; Plants; Plasmids; Pseudomonas; Restriction Mapping; Tryptophan	1993
Synthesis of enantiomerically pure alpha-[14C]methyl-L-tryptophan. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 1993, Volume: 44, Issue:9 Topics: Carbon Radioisotopes; Isotope Labeling; Tryptophan	1993
Pharmacokinetics of alpha-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1 Topics: Animals; Brain; Macaca mulatta; Male; Serotonin; Tryptophan	1996
Ipsilateral alterations in tryptophan hydroxylase activity in rat brain after hypothalamic 5,7-di-hydroxytryptamine lesion. Brain research, 1996, Jun-17, Volume: 724, Issue:2 Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Brain; Functional Laterality; Hypothalamus, Middle; Immunohistochemistry; Male; Medial Forebrain Bundle; Nerve Endings; Nerve Fibers; Neural Pathways; Raphe Nuclei; Rats; Rats, Wistar; Serotonin Agents; Tryptophan; Tryptophan Hydroxylase	1996
Molecular basis of alpha-methyltryptophan resistance in amt-1, a mutant of Arabidopsis thaliana with altered tryptophan metabolism. Plant physiology, 1996, Volume: 110, Issue:4 Topics: Amino Acid Sequence; Anthranilate Synthase; Arabidopsis; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Molecular Sequence Data; Mutation; Plant Growth Regulators; Plant Roots; Sequence Homology, Amino Acid; Tryptophan	1996
A high-yield and simplified procedure for the synthesis of alpha-[11C]methyl-L-tryptophan. Nuclear medicine and biology, 1996, Volume: 23, Issue:8 Topics: Carbon Radioisotopes; Isotope Labeling; Tryptophan	1996
Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Synapse (New York, N.Y.), 1998, Volume: 28, Issue:1 Topics: Adolescent; Adult; Brain; Female; Humans; Male; Serotonin; Statistics as Topic; Tomography, Emission-Computed; Tryptophan	1998
Validation of a less-invasive method for measurement of serotonin synthesis rate with alpha-[11C]methyl-tryptophan. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:10 Topics: Adult; Arteries; Brain; Carbon Radioisotopes; Evaluation Studies as Topic; Female; Humans; Male; Methods; Serotonin; Tomography, Emission-Computed; Tryptophan; Veins	1998
Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1998, Volume: 19, Issue:5 Topics: Animals; Brain; Carbon Radioisotopes; Hydroxyindoleacetic Acid; Macaca mulatta; Male; Serotonin; Tomography, Emission-Computed; Tryptophan	1998
Imaging epileptogenic tubers in children with tuberous sclerosis complex using alpha-[11C]methyl-L-tryptophan positron emission tomography. Annals of neurology, 1998, Volume: 44, Issue:6 Topics: Brain; Carbon Radioisotopes; Child; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Male; Tomography, Emission-Computed; Tryptophan; Tuberous Sclerosis	1998
Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. Journal of neurochemistry, 1999, Volume: 72, Issue:5 Topics: Animals; Autoradiography; Brain; Buspirone; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Time Factors; Tryptophan	1999
Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method. Journal of neurochemistry, 1999, Volume: 72, Issue:6 Topics: Animals; Autoradiography; Brain; Kinetics; Male; Motor Activity; Organ Specificity; Pineal Gland; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Serotonin; Tritium; Tryptophan	1999
The validity of the PET/alpha-[11C]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:1 Topics: Brain; Brain Chemistry; Humans; Kinetics; Reproducibility of Results; Serotonin; Tomography, Emission-Computed; Tryptophan	1999
Effects of serotonergic and opioidergic drugs on escape behaviors and social status of male crickets. Die Naturwissenschaften, 1999, Volume: 86, Issue:9 Topics: Animals; Escape Reaction; Gryllidae; Hierarchy, Social; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid; Serotonin; Tryptophan	1999
Is alpha-methyl-L-tryptophan a good tracer for brain serotonin synthesis measurements, and does the lumped constant vary in different structures of the rat brain? Journal of neurochemistry, 1999, Volume: 73, Issue:6 Topics: Algorithms; Animals; Brain; Hydroxylation; Kinetics; Models, Biological; Radioactive Tracers; Rats; Serotonin; Tryptophan	1999
The influence of endogenous dopamine levels on the density of [3H]SCH23390-binding sites in the brain of the honey bee, Apis mellifera L. Brain research, 2000, Feb-14, Volume: 855, Issue:2 Topics: alpha-Methyltyrosine; Animals; Bees; Benzazepines; Brain; Chromatography, High Pressure Liquid; Dopamine; Female; Receptors, Dopamine; Social Behavior; Tritium; Tryptophan	2000
The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: studies with dual administration of [11C] and [14C] labeled tracer. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:2 Topics: Animals; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebrovascular Circulation; Hydroxyindoleacetic Acid; Macaca mulatta; Male; Serotonin; Tomography, Emission-Computed; Tryptophan	2000
The fight and flight responses of crickets depleted of biogenic amines. Journal of neurobiology, 2000, Volume: 43, Issue:2 Topics: Adrenergic Uptake Inhibitors; Aggression; alpha-Methyltyrosine; Animals; Behavior, Animal; Biogenic Amines; Dimethyl Sulfoxide; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Ganglia, Invertebrate; Gryllidae; Immunohistochemistry; Male; Octopamine; Reserpine; Running; Serotonin; Stereotyped Behavior; Tryptophan	2000
Stereospecific synthesis of alpha-methylated amino acids. Amino acids, 2000, Volume: 18, Issue:1 Topics: Amino Acids; Methylation; Models, Chemical; Stereoisomerism; Tryptophan	2000
Does labeled alpha-methyl-L-tryptophan image ONLY blood-brain barrier transport of tryptophan? Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:10 Topics: Animals; Biological Transport; Blood-Brain Barrier; Humans; Models, Cardiovascular; Models, Neurological; Tryptophan	2000
Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp. Neurochemical research, 2000, Volume: 25, Issue:12 Topics: Animals; Autoradiography; Brain; Nerve Tissue Proteins; Permeability; Rats; Rats, Wistar; Serotonin; Tryptophan	2000
Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. The American journal of psychiatry, 2001, Volume: 158, Issue:5 Topics: Adult; Borderline Personality Disorder; Brain; Carbon Radioisotopes; Cerebral Cortex; Diagnosis, Differential; Female; Humans; Impulsive Behavior; Magnetic Resonance Imaging; Male; Serotonin; Sex Factors; Tomography, Emission-Computed; Tryptophan	2001
Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2001, Volume: 11, Issue:3 Topics: Animals; Autoradiography; Brain; Male; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Tryptophan	2001
The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of alpha-methyl-L-tryptophan: an autoradiographic study. Neurochemistry international, 2002, Volume: 40, Issue:7 Topics: Animals; Autoradiography; Brain; Cycloheximide; Enzyme Inhibitors; Fenclonine; Male; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan; Tryptophan Hydroxylase	2002
Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study. Journal of neurochemistry, 2002, Volume: 80, Issue:5 Topics: Animals; Autoradiography; Body Weight; Brain; Brain Chemistry; Carbon Radioisotopes; Injections, Intraperitoneal; Male; Piperazines; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Tissue Distribution; Tryptophan	2002
Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood. Journal of child neurology, 2002, Volume: 17, Issue:4 Topics: Adolescent; Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Child; Child, Preschool; Female; Hemiplegia; Humans; Image Processing, Computer-Assisted; Infant; Male; Serotonin; Tomography, Emission-Computed; Tryptophan	2002
Serotonin synthesis and its light-dark variation in the rat retina. Journal of neurochemistry, 2002, Volume: 83, Issue:4 Topics: 5-Hydroxytryptophan; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Darkness; Enzyme Inhibitors; Light; Male; Photoperiod; Rats; Rats, Inbred BN; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Tryptophan; Tryptophan Hydroxylase	2002
alpha-[11C]-Methyl-L-tryptophan PET identifies the epileptogenic tuber and correlates with interictal spike frequency. Epilepsy research, 2003, Volume: 52, Issue:3 Topics: Adolescent; Adult; Carbon Radioisotopes; Child, Preschool; Electroencephalography; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiopharmaceuticals; Seizures; Tomography, Emission-Computed; Tryptophan; Tuberous Sclerosis	2003
Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology, 2003, Mar-25, Volume: 60, Issue:6 Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Energy Metabolism; Epilepsy; Female; Fluorodeoxyglucose F18; Humans; Infant; Magnetic Resonance Imaging; Male; Neocortex; Radiopharmaceuticals; Sensitivity and Specificity; Serotonin; Tomography, Emission-Computed; Treatment Outcome; Tryptophan	2003
Sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using alpha-[11C]methyl-L-tryptophan, positron emission tomography and statistical parametric mapping. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2003, Volume: 17, Issue:3 Topics: Adult; Brain; Chronic Disease; Colonic Diseases, Functional; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Risk Factors; Serotonin; Sex Factors; Tomography, Emission-Computed; Tryptophan	2003
Effects of desipramine on regional serotonin synthesis in the rat brain: acute and chronic autoradiographic studies. Neurochemistry international, 2003, Volume: 43, Issue:7 Topics: Adrenergic Uptake Inhibitors; Animals; Autoradiography; Brain; Desipramine; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan	2003
Effects of alpha-methyl-DL-tryptophan on the oxidation of tryptophan. Canadian journal of biochemistry and physiology, 1955, Volume: 33, Issue:5 Topics: Amino Acids; Biochemical Phenomena; Liver; Oxidation-Reduction; Tryptophan; Venoms	1955
[ON THE INCORPORATION OF N-ALPHA-METHYL TRYPTOPHAN AND N-OMEGA-METHYL TRYPTAMINE IN ERGOT ALKALOIDS OF THE CLAVIN TYPE]. Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1963, Volume: 18 Topics: Ascomycota; Ergot Alkaloids; Fungal Proteins; Indoles; Ribonucleases; Tryptamines; Tryptophan	1963
INDUCTION OF TRYPTOPHAN PYRROLASE BY ALPHA-METHYLTRYPTOPHAN AND ITS METABOLIC SIGNIFICANCE IN VIVO. The Journal of biological chemistry, 1963, Volume: 238 Topics: Aged; Carbon Isotopes; Humans; Peroxidases; Proteins; Tryptophan; Tryptophan Oxygenase	1963
The weight-depressing action of alpha-methyl-DL-tryptophan in the rat. Canadian journal of biochemistry and physiology, 1962, Volume: 40 Topics: Animals; Body Weight; Body Weights and Measures; Mental Disorders; Rats; Tryptophan	1962
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nature medicine, 2003, Volume: 9, Issue:10 Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Neoplasm Transplantation; Neoplasms; Placenta; Pregnancy; RNA, Messenger; Tryptophan; Tryptophan Oxygenase; Tumor Escape	2003
Tumors hijack fetal enzyme, escape killer T cells. Nature medicine, 2003, Volume: 9, Issue:10 Topics: Animals; Female; Fetus; Humans; Mice; Neoplasms; Placenta; Pregnancy; T-Lymphocytes, Cytotoxic; Tryptophan; Tryptophan Oxygenase; Tumor Escape	2003
Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Archives of general psychiatry, 2004, Volume: 61, Issue:6 Topics: Brain; Carbon Radioisotopes; Caudate Nucleus; Cerebral Cortex; Depressive Disorder; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Serotonin; Thalamus; Tomography, Emission-Computed, Single-Photon; Tryptophan	2004
Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements. Life sciences, 2004, Dec-03, Volume: 76, Issue:3 Topics: Animals; Anti-Ulcer Agents; Autoradiography; Brain; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Peptide Fragments; Proteins; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan	2004
A simplified autoradiographic method with alpha-[14C]methyl-tryptophan to measure serotonin synthesis rate in the rat brain. Nuclear medicine and biology, 2004, Volume: 31, Issue:8 Topics: Algorithms; Animals; Autoradiography; Brain; Image Interpretation, Computer-Assisted; Male; Metabolic Clearance Rate; Models, Biological; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Serotonin; Tissue Distribution; Tryptophan	2004
Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study. Psychopharmacology, 2005, Volume: 179, Issue:4 Topics: Animals; Autoradiography; Brain Chemistry; Citalopram; Hematocrit; Kinetics; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2005
Selective 5-HT1B receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: results of an autoradiographic study. Neurochemistry international, 2005, Volume: 46, Issue:3 Topics: Animals; Autoradiography; Brain Chemistry; Capillaries; Infusion Pumps, Implantable; Kinetics; Male; Neural Pathways; Pyridines; Pyrroles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin Receptor Agonists; Time Factors; Tryptophan	2005
Octopamine and experience-dependent modulation of aggression in crickets. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-09, Volume: 25, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Agonistic Behavior; Animals; Chlorphenamidine; Dibenzazepines; Dopamine; Flight, Animal; Gryllidae; Imidazoles; Insecticides; Learning; Male; Monoamine Oxidase Inhibitors; Motivation; Neuronal Plasticity; Octopamine; Phentolamine; Propranolol; Receptors, Biogenic Amine; Reflex, Startle; Serotonin; Tryptophan	2005
Serotonin synthesis by two distinct enzymes in Drosophila melanogaster. Archives of insect biochemistry and physiology, 2005, Volume: 59, Issue:1 Topics: Amino Acid Sequence; Animals; Blotting, Southern; Catecholamines; Cyclic AMP-Dependent Protein Kinases; Drosophila melanogaster; Immunoprecipitation; Molecular Sequence Data; Phenylalanine Hydroxylase; Phosphorylation; Sequence Alignment; Serotonin; Substrate Specificity; Tryptophan; Tryptophan Hydroxylase	2005
Brain regional alpha-[11C]methyl-L-tryptophan trapping correlates with post-mortem tissue serotonin content and [11C]5-hydroxytryptophan accumulation. The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:4 Topics: 5-Hydroxytryptophan; Autoradiography; Brain Chemistry; Female; Humans; Male; Serotonin; Tryptophan	2005
Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). Journal of child neurology, 2005, Volume: 20, Issue:5 Topics: Carbon Radioisotopes; Child; Child, Preschool; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Infant; Male; Positron-Emission Tomography; Reproducibility of Results; Treatment Outcome; Tryptophan; Tuberous Sclerosis	2005
In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2006, Volume: 26, Issue:3 Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carbon Radioisotopes; Cerebral Cortex; Child; Child, Preschool; Electroencephalography; Female; Gadolinium; Glucose; Humans; Infant; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Positron-Emission Tomography; Seizures; Sensitivity and Specificity; Tryptophan	2006
The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study. Brain research bulletin, 2005, Oct-15, Volume: 67, Issue:3 Topics: Analysis of Variance; Animals; Autoradiography; Brain; Carbon Isotopes; Enzyme Inhibitors; Male; Piperidones; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan	2005
Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-[(11)C]methyl-L-tryptophan and positron emission tomography. Neurochemistry international, 2005, Volume: 47, Issue:8 Topics: Adolescent; Adult; Brain; Brain Chemistry; Brain Mapping; Carbon Radioisotopes; Cerebrovascular Circulation; Female; Humans; Male; Oxygen; Oxygen Consumption; Positron-Emission Tomography; Serotonin; Tryptophan; Tryptophan Hydroxylase; Up-Regulation	2005
alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:3 Topics: Adult; Brain Mapping; Depressive Disorder; Female; Humans; Image Interpretation, Computer-Assisted; Male; Positron-Emission Tomography; Prefrontal Cortex; Psychiatric Status Rating Scales; Radiopharmaceuticals; Suicide, Attempted; Tryptophan	2006
Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin, 2006, Mar-31, Volume: 69, Issue:2 Topics: Animals; Autoradiography; Brain; Buspirone; Carbon Radioisotopes; Denervation; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Sensory Deprivation; Serotonin; Serotonin Receptor Agonists; Tryptophan	2006
5-Hydroxy-L-[beta-11C]tryptophan versus alpha-[11C]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:4 Topics: 5-Hydroxytryptophan; Animals; Body Weight; Brain Chemistry; Dose-Response Relationship, Drug; Female; Macaca mulatta; Positron-Emission Tomography; Radiopharmaceuticals; Serotonin; Tryptophan	2007
Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males. NeuroImage, 2006, Nov-15, Volume: 33, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Algorithms; Brain Mapping; Cerebral Cortex; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Models, Neurological; Positron-Emission Tomography; Radiopharmaceuticals; Serotonin; Sex Characteristics; Tryptophan	2006
Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: an alpha-methyl-l-tryptophan autoradiographic study. Neurochemistry international, 2007, Volume: 51, Issue:8 Topics: Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Drug Administration Schedule; Infusion Pumps, Implantable; Male; Oxygen Consumption; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Tryptophan	2007
In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states. Journal of psychiatry & neuroscience : JPN, 2007, Volume: 32, Issue:6 Topics: Adult; Affect; Brain; Humans; Male; Positron-Emission Tomography; Serotonin; Tryptophan	2007
Alpha-[11C]methyl-L-tryptophan uptake in patients with periventricular nodular heterotopia and epilepsy. Epilepsia, 2008, Volume: 49, Issue:5 Topics: Adult; Brain Mapping; Carbon Radioisotopes; Control Groups; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Male; Neocortex; Periventricular Nodular Heterotopia; Positron-Emission Tomography; Serotonin; Tryptophan	2008
Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. The Biochemical journal, 2008, Sep-15, Volume: 414, Issue:3 Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Antineoplastic Agents; Biological Transport, Active; Cell Line; Cell Line, Tumor; Humans; Large Neutral Amino Acid-Transporter 1; Mice; Oocytes; Plasma Membrane Neurotransmitter Transport Proteins; Tryptophan; Xenopus laevis	2008
Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study. NeuroImage, 2008, Aug-15, Volume: 42, Issue:2 Topics: Adult; Brain; Female; Humans; Male; Piperazines; Positron-Emission Tomography; Protein Binding; Pyridines; Radiopharmaceuticals; Receptor, Serotonin, 5-HT1A; Serotonin; Statistics as Topic; Tryptophan	2008
Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation. Brain research bulletin, 2008, Oct-22, Volume: 77, Issue:4 Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depressive Disorder; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Serotonin; Species Specificity; Tryptophan	2008
Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations. Pediatric neurology, 2008, Volume: 39, Issue:3 Topics: Adolescent; Brain; Carbon Radioisotopes; Cerebral Cortex; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Female; Fluorodeoxyglucose F18; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Male; Malformations of Cortical Development; Positron-Emission Tomography; Reproducibility of Results; Tryptophan	2008
Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography. Alcoholism, clinical and experimental research, 2009, Volume: 33, Issue:2 Topics: Adult; Alcoholism; Brain; Brain Chemistry; Brain Mapping; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Psychiatric Status Rating Scales; Radiopharmaceuticals; Serotonin; Tryptophan	2009
Quantification of tryptophan transport and metabolism in lung tumors using PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:3 Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Feasibility Studies; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Rectal Neoplasms; Tryptophan	2009
AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats. Neurochemistry international, 2009, Volume: 55, Issue:7 Topics: Animals; Autoradiography; Brain Chemistry; Depression; Enzyme Activation; Linear Models; Piperidones; Rats; Serotonin; Tryptophan; Tryptophan Hydroxylase	2009
Multimodality neuroimaging in Tourette syndrome: alpha-[11C] methyl-L-tryptophan positron emission tomography and diffusion tensor imaging studies. Journal of child neurology, 2010, Volume: 25, Issue:3 Topics: Adolescent; Anisotropy; Brain; Caudate Nucleus; Child; Diffusion Tensor Imaging; Female; Humans; Male; Positron-Emission Tomography; Tourette Syndrome; Tryptophan	2010
Gender differences in alpha-[(11)C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: a positron emission tomography study. Psychiatry research, 2010, Aug-30, Volume: 183, Issue:2 Topics: Adult; Brain; Brain Mapping; Depressive Disorder, Major; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Sex Characteristics; Tryptophan; Young Adult	2010
Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:2 Topics: Algorithms; Animals; Animals, Newborn; Apoptosis; Cell Count; Cerebral Cortex; Endotoxins; Female; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Nick-End Labeling; Magnetic Resonance Imaging; Nerve Fibers; Positron-Emission Tomography; Pregnancy; Rabbits; Raphe Nuclei; Serotonin; Serotonin Plasma Membrane Transport Proteins; Somatosensory Cortex; Tryptophan; Tryptophan Hydroxylase	2011
Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder. Archives of general psychiatry, 2011, Volume: 68, Issue:7 Topics: Adolescent; Adult; Brain; Case-Control Studies; Caudate Nucleus; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Obsessive-Compulsive Disorder; Positron-Emission Tomography; Temporal Lobe; Tryptophan; Young Adult	2011
The lumped constant of α-methyl-l-tryptophan is not influenced by drugs acting through serotonergic system. Neurochemistry international, 2011, Volume: 58, Issue:7 Topics: Animals; Male; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Tryptophan	2011
Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy. Epilepsia, 2011, Volume: 52, Issue:9 Topics: Brain Mapping; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Male; Parietal Lobe; Positron-Emission Tomography; Statistics as Topic; Tryptophan	2011
Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors. Journal of neuro-oncology, 2012, Volume: 107, Issue:2 Topics: Adolescent; Carbon Isotopes; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Large Neutral Amino Acid-Transporter 1; Magnetic Resonance Imaging; Male; Neoplasms, Neuroepithelial; Positron-Emission Tomography; Teratoma; Tryptophan	2012
Serotonin modulates worker responsiveness to trail pheromone in the ant Pheidole dentata. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2012, Volume: 198, Issue:3 Topics: Animal Communication; Animals; Ants; Appetitive Behavior; Neurons; Pheromones; Serotonin; Tryptophan	2012
Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: a 27-year longitudinal study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:6 Topics: Adult; Birth Weight; Brain; Carbon Radioisotopes; Female; Heart Diseases; Humans; Longitudinal Studies; Lung Diseases; Male; Nicotine; Obstetric Labor Complications; Positron-Emission Tomography; Pregnancy; Prenatal Exposure Delayed Effects; Serotonin; Stress, Psychological; Surveys and Questionnaires; Tryptophan	2012
Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies. Nuclear medicine and biology, 2012, Volume: 39, Issue:7 Topics: Adult; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Large Neutral Amino Acid-Transporter 1; Middle Aged; Positron-Emission Tomography; Tryptophan; Tryptophan Hydroxylase	2012
Accurate differentiation of recurrent gliomas from radiation injury by kinetic analysis of α-11C-methyl-L-tryptophan PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:7 Topics: Adult; Aged; Brain Neoplasms; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Glioma; Humans; Image Processing, Computer-Assisted; Ki-67 Antigen; Male; Middle Aged; Neoplasm Recurrence, Local; Radiation Injuries; Radionuclide Imaging; Radiopharmaceuticals; Reference Standards; Reproducibility of Results; ROC Curve; Tryptophan	2012
Both acute and subchronic treatments with pindolol, a 5-HT(1A) and β₁ and β₂ adrenoceptor antagonist, elevate regional serotonin synthesis in the rat brain: an autoradiographic study. Neurochemistry international, 2012, Volume: 61, Issue:8 Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Animals; Autoradiography; Brain; Carbon Radioisotopes; Drug Administration Schedule; Feedback, Physiological; Injections, Intraperitoneal; Male; Organ Specificity; Pindolol; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Tryptophan	2012
α-[11C] methyl-L tryptophan-PET as a surrogate for interictal cerebral serotonin synthesis in migraine without aura. Cephalalgia : an international journal of headache, 2014, Volume: 34, Issue:3 Topics: Administration, Oral; Adult; Brain; Epilepsy; Female; Humans; Migraine without Aura; Positron-Emission Tomography; Pyrrolidines; Radiopharmaceuticals; Serotonin; Serotonin Receptor Agonists; Tissue Distribution; Treatment Outcome; Tryptamines; Tryptophan	2014
Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha-[(11) C]methyl-l-tryptophan study. Journal of neurochemistry, 2014, Volume: 131, Issue:5 Topics: Adult; Antidepressive Agents, Second-Generation; Brain; Brain Mapping; Female; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Positron-Emission Tomography; Self Report; Serotonin; Sex Factors; Substance-Related Disorders; Tryptophan; Young Adult	2014
Measuring effects of MDMA (ecstasy) abuse on the rate of cerebral serotonin synthesis. Journal of neurochemistry, 2014, Volume: 131, Issue:5 Topics: Brain; Female; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Serotonin; Substance-Related Disorders; Tryptophan	2014
The stability of tryptophan, 5-methyl-tryptophan and α-methyl-tryptophan during NaOH hydrolysis of selected foods. Food chemistry, 2015, Dec-01, Volume: 188 Topics: Food Analysis; Hydrolysis; Least-Squares Analysis; Nonlinear Dynamics; Sodium Hydroxide; Tryptophan	2015
Design and automated production of 11C-alpha-methyl-l-tryptophan (11C-AMT). Nuclear medicine and biology, 2016, Volume: 43, Issue:5 Topics: Automation; Drug Design; Positron-Emission Tomography; Quality Control; Radiochemistry; Tryptophan	2016
Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer. British journal of pharmacology, 2016, Volume: 173, Issue:23 Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Antineoplastic Agents; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Molecular Targeted Therapy; Pancreatic Neoplasms; RNA, Messenger; Tryptophan; Up-Regulation; Xenograft Model Antitumor Assays	2016
Prognostic Molecular and Imaging Biomarkers in Primary Glioblastoma. Clinical nuclear medicine, 2017, Volume: 42, Issue:5 Topics: Aged; Biomarkers, Tumor; Carbon Radioisotopes; Central Nervous System Neoplasms; DNA Methylation; ErbB Receptors; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Positron-Emission Tomography; Prognosis; Promoter Regions, Genetic; Tryptophan	2017
A distinct microRNA expression profile is associated with α[ Neurobiology of disease, 2018, Volume: 109, Issue:Pt A Topics: Child; Child, Preschool; Female; Gene Expression; Gene Expression Profiling; Humans; Infant; Male; MicroRNAs; Positron-Emission Tomography; Seizures; Symporters; Tryptophan; Tuberous Sclerosis	2018
The treatment value of IL-1β monoclonal antibody under the targeting location of alpha-methyl-L-tryptophan and superparamagnetic iron oxide nanoparticles in an acute temporal lobe epilepsy model. Journal of translational medicine, 2018, 12-04, Volume: 16, Issue:1 Topics: Acute Disease; Animals; Antibodies, Monoclonal; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Inflammation; Interleukin-1beta; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Rats, Sprague-Dawley; Transcription Factor RelA; Tryptophan	2018
Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis. American journal of respiratory cell and molecular biology, 2019, Volume: 61, Issue:6 Topics: Amino Acid Transport Systems; Arginine; Biological Transport; Bronchi; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Genes, Reporter; Humans; Nitric Oxide; Nitric Oxide Synthase Type II; Recombinant Proteins; Surface Properties; Transduction, Genetic; Tryptophan	2019
SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. The Biochemical journal, 2020, 04-30, Volume: 477, Issue:8 Topics: Amino Acid Transport Systems; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Carcinogens; Cell Line, Tumor; Cell Proliferation; Colon; Colonic Neoplasms; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; TOR Serine-Threonine Kinases; Tryptophan; Wnt Signaling Pathway	2020
Synthesis and Preclinical Evaluation of 6-[ ACS chemical neuroscience, 2020, 06-17, Volume: 11, Issue:12 Topics: Animals; Fluorine; Kynurenine; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Tryptophan	2020
Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells. The Biochemical journal, 2020, 05-29, Volume: 477, Issue:10 Topics: Amino Acid Transport Systems; Amino Acids; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Metabolomics; Pancreatic Neoplasms; Tryptophan	2020
α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice. The Biochemical journal, 2021, 04-16, Volume: 478, Issue:7 Topics: Amino Acid Transport Systems; Animals; Anti-Obesity Agents; Diet, High-Fat; Disease Models, Animal; Female; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Tryptophan	2021
Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase. Proceedings of the National Academy of Sciences of the United States of America, 2021, 06-08, Volume: 118, Issue:23 Topics: Animals; HEK293 Cells; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Tryptophan; Tryptophan Oxygenase; Ubiquitination	2021
The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation. Biomolecules, 2021, 10-15, Volume: 11, Issue:10 Topics: Acute Kidney Injury; Animals; Azo Compounds; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; DNA Damage; Enzyme Inhibitors; Epithelial Cells; Humans; Hypoxia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kidney Tubules, Proximal; Mice; Oxygen; Protein Serine-Threonine Kinases; Pyrazoles; Receptors, Aryl Hydrocarbon; Reperfusion Injury; rho GTP-Binding Proteins; Tryptophan	2021