tryptophan has been researched along with 3-hydroxykynurenine in 114 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (14.91) | 18.7374 |
| 1990's | 21 (18.42) | 18.2507 |
| 2000's | 23 (20.18) | 29.6817 |
| 2010's | 49 (42.98) | 24.3611 |
| 2020's | 4 (3.51) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, RR; Leklem, JE | 1 |
| Clark, JA; Clark, MS; Palfreyman, ES; Palfreyman, MG | 1 |
| Heyes, MP; Markey, SP; Saito, K | 1 |
| Bender, DA; Njagi, EN | 1 |
| Heyes, MP; Quearry, BJ | 1 |
| Hashizume, T; Kinae, N; Kosaka, K; Ozawa, T; Santo, H; Tsujisawa, H; Yamashita, M | 1 |
| Savvateeva, E | 1 |
| Baran, H; Schwarcz, R | 1 |
| Fujimoto, H; Haneda, M; Nakatsuka, M; Nisimoto, Y; Nomura, S; Ohta, T; Shibata, Y; Takeuchi, F; Tamai, T; Tsubouchi, R | 1 |
| Ishiguro, I; Nagamura, Y; Naito, J; Ogawa, H | 1 |
| Bender, DA | 2 |
| Heyes, MP; Markey, SP; Quearry, BJ | 1 |
| Pearson, SJ; Reynolds, GP | 1 |
| Izuta, S; Shibata, Y; Takeuchi, F; Tsubouchi, R | 1 |
| Abdel-Hamied, HA; Abdel-Tawab, GA; Aboul-Azm, T; Ebied, SA; el-Kholy, ZA; el-Sharaky, AS; el-Toukhy, MA | 1 |
| Evangelista, SJ; Rogers, KS | 1 |
| Shirasawa, E; Tomoda, A; Yoneyama, Y | 1 |
| Dillon, J; Roy, D; Spector, A | 1 |
| Møller, SE | 1 |
| Karawya, E; Mostafa, MH; Osman, N | 1 |
| Shibata, Y; Takeuchi, F | 1 |
| Cardin de' Stefani, E; Costa, C | 1 |
| Allegri, G; Cardin Dè Stefani, EL; Costa, C; De Antoni, A; Vanzan, S | 1 |
| Court, S; Edson, J; Lacey, K; McKiernan, J; Mellor, D | 1 |
| Abe, T; Hamato, H; Takahashi, J; Takahashi, S; Tohgi, H | 1 |
| Truscott, RJ; Wood, AM | 2 |
| Hiraku, Y; Inoue, S; Kawanishi, S; Nishino, K; Oikawa, S; Tada, S; Yamamoto, K | 1 |
| Koch, PB | 1 |
| Iguchi, T; Imai, J; Kawai, M; Murayama, K; Sakai, Y; Shimizu, H; Sumi, T; Yamaguchi, S; Yoshida, I | 1 |
| Watanabe, M | 1 |
| Li, G; Li, J | 1 |
| Beerntsen, BT; James, AA; Li, J | 1 |
| Hasegawa, H; Hasegawa, Y; Ikeda, R; Nagamura, Y; Naito, J; Negishi, S | 1 |
| Bova, LM; Jamie, JF; Truscott, RJ; Wood, AM | 1 |
| Pawlak, D; Takada, A; Takada, Y; Urano, T | 1 |
| Atwood, CS; Bowden, EF; Bush, AI; Chylack, LT; Faget, KY; Goldstein, LE; Hartshorn, M; Huang, X; Leopold, MC; Lim, JT; Muffat, JA; Saunders, AJ; Scarpa, RC; Tanzi, RE | 1 |
| Bragina, J; Heisenberg, M; Kamyshev, N; Kornhuber, J; Popov, A; Riederer, P; Savvateeva, E; Senitz, D | 1 |
| Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Buczko, W; Chabielska, E; Pawlak, D; Tankiewicz, A; Topczewska-Bruns, J | 1 |
| Bauer, TM; Dufter, C; Opelz, G; Röse, L; Simon, H; Terness, P; Watzlik, A | 1 |
| Baran, H; Draxler, M; Kepplinger, B; Nohl, H; Staniek, K; Stur, J | 1 |
| Liao, W; Lu, X; Yi, Y; Zhao, Q | 1 |
| Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW | 1 |
| DALGLIESH, CE; TEKMAN, S | 1 |
| Buczko, W; Pawlak, D; Tankiewicz, A; Topczewska-Bruns, J | 1 |
| Allegri, G; Bertazzo, A; Comai, S; Costa, CV; Seraglia, R; Traldi, P; Vogliardi, S | 1 |
| Campagnoli, M; Galliano, M; Labò, S; Minchiotti, L; Monzani, E; Perani, E; Romano, A; Sala, A | 1 |
| Nagaraj, RH; Staniszewska, MM | 1 |
| Aquilina, JA; Hains, PG; Korlimbinis, A; Truscott, RJ | 1 |
| Korlimbinis, A; Truscott, RJ | 1 |
| Cornelio, AR; de Souza Wyse, AT; Dutra-Filho, CS; Rech, VC; Rodrigues-Junior, Vda S; Wajner, M; Wannmacher, CM | 1 |
| Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J | 1 |
| Boullanger, S; Chaker, H; Derouazi, M; Filopon, D; Polack, B; Shen, DK; Toussaint, B | 1 |
| Backhaus, C; Hardeland, R; Laatsch, H; Rahman, H; Scheffler, S | 1 |
| Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Kakimi, K; Kubo, K; Motomura, N; Narui, K; Noguchi, N; Saito, A; Sasatsu, M; Takamoto, S | 1 |
| Bakker, SJ; de Jong, WH; de Vries, EG; Kema, IP; Smit, R | 1 |
| Dougherty, GG; Kaddurah-Daouk, R; Keshavan, MS; Krishnan, RR; Matson, WR; McEvoy, J; Montrose, DM; Reddy, RD; Rozen, S; Yao, JK | 1 |
| Mysliwiec, M; Pawlak, D; Pawlak, K; Tankiewicz, J | 1 |
| Bianchini, R; Daly, S; Jachowicz, J; Jumbelic, L; Polefka, T | 1 |
| Armstrong, K; Barnett, MP; Ferguson, LR; Helsby, NA; Joyce, NI; Lin, HM; Rowan, DD; Roy, NC; Zhu, S | 1 |
| Barone, PR; Belzung, C; Callebert, J; Laugeray, A; Launay, JM; Surget, A | 1 |
| Amori, L; Guidetti, P; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R; Stachowski, EK | 1 |
| Dauvermann, MR; Myint, AM; Oades, RD; Schimmelmann, BG; Schwarz, MJ | 1 |
| Bien, B; Gulaj, E; Pawlak, D; Pawlak, K | 1 |
| Condray, R; Dougherty, GG; Haas, GL; Kaddurah-Daouk, R; Keshavan, MS; Matson, WR; McEvoy, J; Montrose, DM; Reddy, RD; Yao, JK | 1 |
| Kim, YK; Leonard, BE; Mueller, HH; Myint, AM; Scharpé, S; Schwarz, MJ; Steinbusch, HW; Verkerk, R; Zach, J | 1 |
| Breda, C; Campesan, S; Giorgini, F; Green, EW; Kyriacou, CP; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Agraharm, SG; Gundae, S; Munipally, PK; Turlapati, NR; Valavala, VK | 1 |
| Notarangelo, FM; Schwarcz, R; Wang, JZ; Wang, XD | 1 |
| Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ | 1 |
| Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE | 1 |
| Fukuwatari, T; Hiratsuka, C; Saito, K; Sano, M; Sasaki, S; Shibata, K | 1 |
| Bezrukov, MV; Shilov, IuE | 1 |
| Chi, YY; Coats, B; da Silva, VR; Garrett, TJ; Gregory, JF; Lamers, Y; Midttun, Ø; Muller, KE; Percival, SS; Quinlivan, EP; Ralat, MA; Rios-Avila, L; Shankar, MN; Stacpoole, PW; Ueland, PM | 1 |
| Ding, Y; Song, P; Wang, Q; Zhang, M; Zhang, W; Zou, MH | 1 |
| Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH | 1 |
| Duran, C; San Martín, A | 1 |
| Cao, X; Hou, W; Huang, G; Li, Y; Zhang, J; Zhang, Y | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Fukuwatari, T; Ohno, T; Sano, M; Shibata, K | 1 |
| Bartram, S; Boland, W; Pesek, J; Sattler, M; Svoboda, J | 1 |
| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
| Fukuda, K | 1 |
| Arts, B; Drukker, M; Guloksuz, S; Kenis, G; Myint, AM; Ponds, R; Rodriguez, L; Rutten, BP; Schwarz, MJ; van Os, J; Walter, S | 1 |
| Brody, LC; Brosnan, JT; Brosnan, ME; Deac, OM; Fan, R; Gibney, ER; Laird, E; Midttun, Ø; Mills, JL; Molloy, AM; Shane, B; Ueland, PM; Wang, Y | 1 |
| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Ralat, M; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
| Badawy, AA; Bano, S | 1 |
| Bergink, V; Burgerhout, KM; Drexhage, HA; Hoogendijk, WJ; Kushner, SA; Myint, AM; Schütze, G; Schwarz, MJ; Veen, C | 1 |
| Dierkes, J; Drevon, CA; Gudbrandsen, OA; Karlsson, T; Midttun, Ø; Nygård, O; Pedersen, ER; Strand, E; Ueland, PM; Øyen, J | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| de Bie, J; Grant, R; Guest, J; Guillemin, GJ | 1 |
| Azzinnari, D; Bergamini, G; Cathomas, F; Ceci, A; Fuertig, R; Hengerer, B; Luippold, A; Pryce, CR; Seifritz, E; Sigrist, H; Vavassori, S | 1 |
| Dabrowska, M; Jasiewicz, M; Kaminski, KA; Kazimierczyk, R; Knapp, M; Moniuszko, M; Musial, WJ; Pawlak, D; Rusak, M | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M | 1 |
| Budac, DP; Elfving, B; Eskelund, A; Sanchez, C; Wegener, G | 1 |
| Dekker, FW; Franssen, CF; Haverkamp, GL; Honig, A; Kema, IP; Loosman, WL; Siegert, CE; van Diepen, M | 1 |
| Engberg, G; Erhardt, S; Goiny, M; Liu, XC; Mathé, AA | 1 |
| Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM | 1 |
| Imamura, Y; Mouri, A; Murakami, Y; Nabeshima, T; Saito, K; Tashiro, T; Yamamoto, Y | 1 |
| Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Hörmanseder, C; Kainzbauer, N; Maget, A; Mangge, H; Mansur, RB; McIntyre, RS; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, EZ; Schütze, G; Schwarz, MJ; Zelzer, S | 1 |
| Bakker, SJL; Berger, SP; de Vries, LV; Franssen, CFM; Kema, IP; Minović, I; Navis, G; Sanders, JS; van Faassen, M | 1 |
| Beggiato, S; Bonnin, A; Goeden, N; Notarangelo, FM; Pocivavsek, A; Schwarcz, R | 1 |
| Fülöp, F; Hertelendy, P; Toldi, J; Vécsei, L | 1 |
| Bryn, V; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Bos, EH; Kema, IP; Sorgdrager, FJH; Van Beek, AP; Werumeus Buning, J | 1 |
| Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M | 1 |
| Böhmová, A; Horáček, J; Kodym, P; Krsek, D; Mikoška, M; Syslová, K; Tejkalová, H; Vacek, L; Vondroušová, J | 1 |
| Anderson, JF; Dahmani, M; Neelakanta, G; Sultana, H | 1 |
| Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS | 1 |
| Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S | 1 |
| Alitalo, K; Arasa, J; Beck, A; Cara, LCL; Chalmers, S; Clement, CC; D'Alessandro, A; Demaria, S; Fallarino, F; Fernandez-Rodriguez, R; Formenti, S; Furtado, R; Gadina, M; Galarini, R; Gargaro, M; Gehrke, S; Grohmann, U; Halin, C; Ianni, F; Karaman, S; Lauvau, G; Macchiarulo, A; Manni, G; Mondanelli, G; Moretti, S; Putterman, C; Runge, P; Santambrogio, L; Sardella, R; Skobe, M; Soni, RK; Spada, S; Thangaswamy, S; Tsai, WL; Veldhoen, M | 1 |
4 review(s) available for tryptophan and 3-hydroxykynurenine
| Article | Year |
|---|---|
[Microanalysis of tryptophan metabolites].
Topics: 3-Hydroxyanthranilic Acid; Animals; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Mice; Microchemistry; Tryptophan; Ultraviolet Rays; Urinary Bladder Neoplasms | 1997 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; Kynurenine; Quinolinic Acid; Tryptophan | 2003 |
[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Topics: Humans; Hydroxyindoleacetic Acid; Kynurenine; Mental Disorders; Psychotic Disorders; Tryptophan; Xanthurenates | 2013 |
Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects.
Topics: Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Stroke; Tryptophan | 2018 |
4 trial(s) available for tryptophan and 3-hydroxykynurenine
| Article | Year |
|---|---|
3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Humans; Kynurenine; Monte Carlo Method; Neuropsychological Tests; Psychotic Disorders; Schizophrenia; Tryptophan; Young Adult | 2011 |
Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Kynurenic Acid; Kynurenine; Niacinamide; ortho-Aminobenzoates; Placebos; Tryptophan; Young Adult | 2013 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Metabolome; Pyridoxal Phosphate; Tryptophan; United States; Vitamin B 6; Vitamin B 6 Deficiency | 2015 |
Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial.
Topics: Adrenal Insufficiency; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fatigue; Female; Humans; Hydrocortisone; Kynurenine; Male; Middle Aged; Quality of Life; Signal Transduction; Treatment Outcome; Tryptophan | 2018 |
106 other study(ies) available for tryptophan and 3-hydroxykynurenine
| Article | Year |
|---|---|
Abnormal tryptophan metabolism in a family with a history of bladder cancer.
Topics: Aged; Female; Humans; Kynurenine; Male; Metabolism, Inborn Errors; Middle Aged; Pyridoxine; Tryptophan; Urinary Bladder Neoplasms | 1976 |
The effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet.
Topics: 3-Hydroxyanthranilic Acid; 5-Hydroxytryptophan; Animals; Brain; Depression; Diet; Drug Synergism; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1975 |
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1992 |
Tryptophan metabolism in mice infected with Schistosoma mansoni.
Topics: Animals; Cells, Cultured; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Niacinamide; Schistosomiasis mansoni; Serotonin; Tryptophan; Xanthurenates | 1991 |
Increased L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid concentrations in cerebral cortex following systemic endotoxin administration.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Quinolinic Acid; Quinolinic Acids; Serotonin; Stimulation, Chemical; Tryptophan | 1991 |
Mutagenic activities of tryptophan metabolites before and after nitrite treatment.
Topics: Biotransformation; Hydrogen-Ion Concentration; Indoles; Kynurenine; Molecular Structure; Mutagens; Nitrites; Salmonella typhimurium; Serotonin; Tryptophan | 1991 |
Kynurenines in the regulation of behavior in insects.
Topics: Action Potentials; Animal Communication; Animals; Bees; Behavior, Animal; Calmodulin; Drosophila melanogaster; Eye Color; Genes; Genotype; Insecta; Kynurenic Acid; Kynurenine; Learning; Phenothiazines; Stimulation, Chemical; Structure-Activity Relationship; Tryptophan; Xanthurenates | 1991 |
Evidence for the preferential production of 3-hydroxyanthranilic acid from anthranilic acid in the rat brain.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Kynurenine; Male; Mixed Function Oxygenases; Organ Specificity; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Tryptophan | 1991 |
On kynureninase activity.
Topics: Animals; Apoenzymes; Benzothiazoles; Cysteine; Dithionitrobenzoic Acid; Dithiothreitol; Enzyme Activation; Hydrolases; Kynurenine; Liver; Magnesium; Male; Phenylpyruvic Acids; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine; Xanthurenates | 1991 |
Rat skin tryptophan 2,3-dioxygenase.
Topics: Animals; Hair; Kynurenine; Liver; Rats; Skin; Tryptophan; Tryptophan Oxygenase | 1991 |
Inhibition of tryptophan----niacin metabolism by dietary leucine and by leucine and 2-oxo-isocaproate in vitro.
Topics: Animals; Cells, Cultured; Depression, Chemical; Dietary Proteins; Keto Acids; Kynurenine; Leucine; Liver; NADP; Niacin; Niacinamide; Pellagra; Rats; Tryptophan; Xanthurenates | 1991 |
Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex.
Topics: Animals; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Kynurenine; Mice; Mice, Inbred C57BL; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Time Factors; Tryptophan | 1989 |
Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells.
Topics: Animals; Caproates; In Vitro Techniques; Keto Acids; Kynurenine; Leucine; Liver; Male; NAD; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan; Xanthurenates | 1989 |
Increased brain 3-hydroxykynurenine in Huntington's disease.
Topics: Brain Chemistry; Cerebral Cortex; Humans; Huntington Disease; Kynurenine; Tryptophan | 1989 |
Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Male; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Transaminases; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1989 |
The correlation between certain tryptophan metabolites and the N-nitrosamine content in the urine of bilharzial bladder cancer patients.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aminohippuric Acids; Colorimetry; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrosamines; ortho-Aminobenzoates; Schistosomiasis haematobia; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1986 |
3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets.
Topics: 3-Hydroxyanthranilic Acid; Aminophenols; Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kynurenine; Leucine; Male; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tryptophan | 1985 |
Reactions of oxy- and methemoglobin with tryptophan metabolites, 3-hydroxyanthranilic acid and 3-hydroxykynurenine.
Topics: 3-Hydroxyanthranilic Acid; Humans; Kinetics; Kynurenine; Methemoglobin; ortho-Aminobenzoates; Oxidation-Reduction; Oxyhemoglobins; Phytic Acid; Protein Binding; Spectrophotometry; Structure-Activity Relationship; Tryptophan | 1986 |
The photolysis of lens fiber membranes.
Topics: Amino Acids; Animals; Aquaporins; Cattle; Electrophoresis, Polyacrylamide Gel; Eye Proteins; Glutathione; Histidine; In Vitro Techniques; Kynurenine; Lens Cortex, Crystalline; Lens, Crystalline; Membrane Glycoproteins; Photolysis; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan | 1985 |
Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects.
Topics: Adult; Female; Humans; Kidney; Kinetics; Kynurenine; Male; Niacinamide; Tryptophan; Tryptophan Oxygenase | 1981 |
The kinetic mechanism of inhibition of liver pyridoxal kinase with tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Animals; Kinetics; Kynurenine; Liver; Phosphotransferases; Pyridoxal Kinase; Quinolinic Acids; Sheep; Tryptophan; Xanthurenates | 1981 |
Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Lyases; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Transaminases; Tryptophan; Vitamin B 6 Deficiency | 1984 |
[Tryptophan metabolism in syphilis infections].
Topics: Adult; Female; Humans; Kynurenine; Male; Middle Aged; Syphilis; Tryptophan; Xanthurenates | 1984 |
Alterations of the tryptophan--nicotinic acid metabolism in vitiligo.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Melanins; Mixed Function Oxygenases; Models, Biological; Niacin; Tryptophan; Vitiligo; Xanthurenates | 1982 |
Hydroxykynurenine/hydroxyanthranilic acid ratios and febrile convulsions.
Topics: 3-Hydroxyanthranilic Acid; Child, Preschool; Humans; Infant; Kynurenine; ortho-Aminobenzoates; Seizures; Seizures, Febrile; Time Factors; Tryptophan | 1980 |
Concentrations of serotonin and its related substances in the cerebrospinal fluid of parkinsonian patients and their relations to the severity of symptoms.
Topics: 5-Hydroxytryptophan; Humans; Hydroxyindoleacetic Acid; Kynurenine; Middle Aged; Parkinson Disease; Reference Values; Serotonin; Tryptophan | 1993 |
Gourami lenses convert tryptophan into 3-hydroxykynurenine.
Topics: Animals; Chromatography, High Pressure Liquid; Fishes; Kynurenine; Lens, Crystalline; Organ Culture Techniques; Tryptophan | 1994 |
Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Animals; Autoradiography; Base Sequence; Carcinogens; Cattle; Cells, Cultured; Copper; DNA; DNA Damage; Free Radical Scavengers; Genes, ras; Humans; Indicators and Reagents; Kynurenine; Manganese Poisoning; Molecular Sequence Data; Oxidation-Reduction; Phenanthrolines; Phosphorus Radioisotopes; Spectrophotometry, Ultraviolet; Tryptophan | 1995 |
Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Chromatography, High Pressure Liquid; Glucosides; Humans; Kynurenine; Lens, Crystalline; Middle Aged; Organ Culture Techniques; Tryptophan | 1994 |
Production of [14C]-labeled 3-hydroxy-L-kynurenine in a butterfly, Heliconius charitonia L. (Heliconidae), and precursor studies in butterfly wing ommatins.
Topics: Amino Acids; Animals; Butterflies; Chromatography, Thin Layer; Kynurenine; Oxazines; Pigments, Biological; Pupa; Tryptophan; Wings, Animal; Xanthenes | 1993 |
Determination of the 8-methyl ether of xanthurenic acid in human serum by high-performance liquid chromatography with fluorescence detection.
Topics: Amino Acid Metabolism, Inborn Errors; Chromatography, High Pressure Liquid; Ethers; Humans; Kynurenine; Sensitivity and Specificity; Silicon Dioxide; Spectrometry, Fluorescence; Tryptophan; Xanthurenates | 1996 |
Transamination of 3-hydroxykynurenine to produce xanthurenic acid: a major branch pathway of tryptophan metabolism in the mosquito, Aedes aegypti, during larval development.
Topics: Aedes; Animals; Kynurenine; Larva; Transaminases; Tryptophan; Xanthurenates | 1997 |
Oxidation of 3-hydroxykynurenine to produce xanthommatin for eye pigmentation: a major branch pathway of tryptophan catabolism during pupal development in the yellow fever mosquito, Aedes aegypti.
Topics: Aedes; Amino Acids; Animals; Eye Color; Hydrogen-Ion Concentration; Insect Proteins; Kynurenine; Monophenol Monooxygenase; Oxazines; Oxidation-Reduction; Pigments, Biological; Pupa; Reactive Oxygen Species; Tissue Distribution; Tryptophan; Xanthenes | 1999 |
Ommochrome deficiency in an albino strain of a terrestrial isopod, Armadillidium vulgare.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Crustacea; Female; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Oxazines; Phenothiazines; Phenotype; Pigmentation; Pigments, Biological; Sex Factors; Tryptophan; Tryptophan Oxygenase; Xanthenes | 1999 |
UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside.
Topics: Acrylates; Adult; Aging; Benzoates; Chromatography, High Pressure Liquid; Deamination; Fetus; Glucosides; Humans; Hydrogen-Ion Concentration; Infant; Kynurenine; Lens, Crystalline; Middle Aged; Phenylbutyrates; Propionates; Tryptophan; Ultraviolet Rays | 1999 |
Serotonergic and kynurenic pathways in rats exposed to foot shock.
Topics: Animals; Brain; Brain Chemistry; Electroshock; Hydroxyindoleacetic Acid; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Rats; Rats, Wistar; Serotonin; Stress, Physiological; Tryptophan | 2000 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Topics: 3-Hydroxyanthranilic Acid; Animals; Ascorbic Acid; Cataract; Cattle; Copper; Crystallins; Electrochemistry; Humans; Hydrogen Peroxide; Iron; Kynurenine; Lens, Crystalline; Metals; Oxidation-Reduction; Superoxides; Tryptophan | 2000 |
Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.
Topics: Age Factors; Animals; Courtship; Drosophila; Kynurenic Acid; Kynurenine; Learning; Male; Memory Disorders; Mutation; Neuroglia; Tryptophan | 2000 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates | 2001 |
Increased levels of 3-hydroxykynurenine in different brain regions of rats with chronic renal insufficiency.
Topics: Animals; Brain; Kidney Failure, Chronic; Kynurenine; Male; Rats; Rats, Wistar; Signal Transduction; Tryptophan; Uremia | 2002 |
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Cell Death; Cell Division; Cytotoxicity Tests, Immunologic; Dendritic Cells; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; T-Lymphocytes; Time Factors; Tryptophan; Tryptophan Oxygenase | 2002 |
Kynurenines and the respiratory parameters on rat heart mitochondria.
Topics: 3-Hydroxyanthranilic Acid; Animals; Free Radical Scavengers; In Vitro Techniques; Kinetics; Kynurenine; Male; Mitochondria, Heart; Mitochondrial Proteins; NAD; ortho-Aminobenzoates; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Succinates; Tryptophan | 2003 |
[Separation and detection of tryptophan metabolites in biological samples].
Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Kynurenine; Serotonin; Trichloroacetic Acid; Tryptophan | 1999 |
The excretion of kynurenine and 3-hydroxykynurenine by man.
Topics: Biological Transport; Humans; Kynurenine; Male; Tryptophan; Urine | 1954 |
Kidney and liver kynurenine pathway enzymes in chronic renal failure.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Failure, Chronic; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Wistar; Tryptophan; Tryptophan Oxygenase | 2003 |
An investigation on the role of 3-hydroxykynurenine in pigment formation by matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Agaricales; Kynurenine; Molecular Structure; Monophenol Monooxygenase; Pigments, Biological; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tryptophan | 2004 |
Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores.
Topics: Alpha-Globulins; Amniotic Fluid; Carrier Proteins; Chromatography, High Pressure Liquid; Dimerization; DNA Adducts; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Kynurenine; Lipocalin 1; Mass Spectrometry; Models, Chemical; Oxidation-Reduction; Oxygen; Protein Binding; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Time Factors; Tryptophan; Ultraviolet Rays | 2004 |
3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antigens; Arginine; Binding, Competitive; Blotting, Western; Cell Membrane; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Histidine; Humans; Immunohistochemistry; Kynurenine; Lens, Crystalline; Lysine; Magnetic Resonance Spectroscopy; Models, Chemical; Ninhydrin; Oxygen; Protein Conformation; Spectrophotometry; Time Factors; Tryptophan; Water | 2005 |
3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.
Topics: alpha-Crystallins; Animals; Catalysis; Cataract; Cattle; Chromatography, High Pressure Liquid; Cysteine; Humans; Kynurenine; Lens, Crystalline; Mass Spectrometry; Methionine; Oxidation-Reduction; Oxidative Stress; Sunscreening Agents; Tryptophan; Ultraviolet Rays | 2006 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduction; Peptides; Pigmentation; Protein Binding; Proteins; Solubility; Sunscreening Agents; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
Inhibition of creatine kinase activity from rat cerebral cortex by 3-hydroxykynurenine.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Creatine Kinase; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Kynurenine; Mitochondria; Rats; Rats, Wistar; Sulfhydryl Compounds; Tryptophan | 2006 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Disease Models, Animal; Electroencephalography; Encephalitis, Viral; Hippocampus; Kynurenine; Measles virus; Mice; Mice, Inbred BALB C; Microglia; Monitoring, Physiologic; Nerve Degeneration; Neuroglia; Pyramidal Cells; Quinolinic Acid; Seizures; Tryptophan | 2008 |
High-cell-density regulation of the Pseudomonas aeruginosa type III secretion system: implications for tryptophan catabolites.
Topics: Bacterial Proteins; Gene Expression Regulation, Bacterial; Indoleacetic Acids; Kynurenine; Mutation; Protein Transport; Pseudomonas aeruginosa; Tryptophan; Virulence Factors | 2008 |
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compounds; Free Radical Scavengers; Hydrazines; Inflammation; Kynurenine; Magnetic Resonance Imaging; Mass Spectrometry; Nitric Oxide; Nitrites; Nitrosation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Oxadiazoles; Quinones; Tryptophan | 2008 |
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.
Topics: Adult; Age Factors; Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Inflammation; Kidney Failure, Chronic; Kynurenine; Logistic Models; Male; Middle Aged; Oxidative Stress; Peroxides; Prevalence; Risk Assessment; Risk Factors; Sex Factors; Superoxide Dismutase; Tryptophan | 2009 |
Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Iron Chelating Agents; Kynurenine; Methicillin-Resistant Staphylococcus aureus; Picolinic Acids; Time Factors; Tryptophan | 2009 |
Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Middle Aged; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2009 |
Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Melatonin; Oxidative Stress; Schizophrenia; Serotonin; Tryptophan; Young Adult | 2010 |
Tissue factor/its pathway inhibitor system and kynurenines in chronic kidney disease patients on conservative treatment.
Topics: Adult; Aged; Case-Control Studies; Chronic Disease; Female; Humans; Kidney Diseases; Kynurenine; Lipoproteins; Male; Middle Aged; Thromboplastin; Tryptophan | 2009 |
Fluorescence and coloration of grey hair.
Topics: Hair Color; Humans; Kynurenine; Spectrometry, Fluorescence; Tryptophan | 2009 |
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.
Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free Life; Inflammation; Interleukin-10; Kynurenine; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Transgenic; Principal Component Analysis; Tryptophan; Urine | 2010 |
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
Topics: Animals; Brain; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Hydroxyindoleacetic Acid; Kynurenine; Lung; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Serotonin; Stress, Psychological; Tryptophan | 2010 |
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.
Topics: Age Factors; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Huntingtin Protein; Huntington Disease; Kynurenine; Metabolic Diseases; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; Time Factors; Tritium; Tryptophan | 2010 |
Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism--effects of medication.
Topics: Adolescent; Amino Acids; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Child; Cytokines; Energy Metabolism; Female; Humans; Kynurenine; Male; Nerve Growth Factors; Neuroglia; Pilot Projects; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tryptophan | 2010 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2010 |
Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients.
Topics: Adult; Algorithms; Antipsychotic Agents; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Patient Discharge; Schizophrenia; Schizophrenic Psychology; Spectrophotometry, Ultraviolet; Treatment Outcome; Tryptophan | 2011 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington Disease; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Nerve Degeneration; Neuroprotective Agents; Tryptophan; Tryptophan Oxygenase | 2011 |
Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients.
Topics: Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Female; Gene Expression; Humans; India; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Retina; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Tryptophan | 2011 |
Kynurenic acid and 3-hydroxykynurenine production from D-kynurenine in mice.
Topics: Animals; Brain Chemistry; Catalysis; Female; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred Strains; Stereoisomerism; Tryptophan | 2012 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan | 2013 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates | 2013 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2013 |
Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.
Topics: Animals; Apoptosis; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Tryptophan; Up-Regulation | 2014 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan | 2014 |
Do endothelial cells eat tryptophan to die?
Topics: Animals; Apoptosis; Endothelium, Vascular; Humans; Kynurenine; NADPH Oxidases; Tryptophan | 2014 |
Suppression of experimental autoimmune glomerulonephritis by tryptophan.
Topics: 3-Hydroxyanthranilic Acid; Animals; Anti-Glomerular Basement Membrane Disease; Apoptosis; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Free Radical Scavengers; Glomerular Filtration Rate; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Proteinuria; Rats; Rats, Inbred WKY; Th1 Cells; Th2 Cells; Tryptophan | 2014 |
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan | 2015 |
The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
Topics: 3-Hydroxyanthranilic Acid; Amino Acid Metabolism, Inborn Errors; Animals; Diet; Hydrolases; Kynurenine; Male; Rats, Wistar; Tryptophan; Weight Gain | 2014 |
Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis.
Topics: Animals; Anti-Bacterial Agents; Hydroxyquinolines; Intestinal Mucosa; Intestines; Iron Chelating Agents; Kynurenine; Larva; Spodoptera; Tryptophan | 2015 |
Etiological classification of depression based on the enzymes of tryptophan metabolism.
Topics: Antidepressive Agents; Brain; Depressive Disorder; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Pituitary-Adrenal System; Serotonin; Stress, Psychological; Suicide; Tryptophan; Tryptophan Hydroxylase | 2014 |
The impact of electroconvulsive therapy on the tryptophan-kynurenine metabolic pathway.
Topics: Adult; Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan; Young Adult | 2015 |
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Arginine; Biomarkers; Dietary Supplements; Female; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Life Style; Male; Methionine; ortho-Aminobenzoates; Pyridoxal Phosphate; Sex Factors; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Xanthurenates; Young Adult | 2015 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary Supplements; Female; Glycine; Homocysteine; Humans; Kynurenine; Leucine; Methionine; Methylamines; Multivariate Analysis; Pyridoxal Phosphate; Pyridoxine; Serine; Tryptophan; Vitamin B 6 Deficiency; Young Adult | 2015 |
Elevation of Kynurenine Metabolites in Rat Liver and Serum: A Potential Additional Mechanism of the Alcohol Aversive and Anti-cancer Effects of Disulfiram?
Topics: 3-Hydroxyanthranilic Acid; Alcohol Deterrents; Animals; Chromatography, High Pressure Liquid; Disulfiram; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Rats; Rats, Wistar; Transaminases; Tryptophan | 2016 |
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.
Topics: Adult; Depression, Postpartum; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Postpartum Period; Psychotic Disorders; Puerperal Disorders; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2016 |
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Animals; Biomarkers; Body Mass Index; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Energy Intake; Fatty Acids, Omega-3; Female; Fishes; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutrition Assessment; ortho-Aminobenzoates; Seafood; Triglycerides; Tryptophan; Xanthurenates | 2017 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult | 2016 |
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Citalopram; Fear; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha | 2016 |
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; Exercise Test; Female; Flow Cytometry; Humans; Hypertension, Pulmonary; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Prospective Studies; ROC Curve; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan | 2016 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2015 |
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan | 2016 |
The role of tryptophan degradation in the association between inflammatory markers and depressive symptoms in chronic dialysis patients.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Depression; Female; Glomerulonephritis; Humans; Incidence; Interleukin-10; Interleukin-1beta; Interleukin-6; Kynurenine; Male; Middle Aged; Prospective Studies; Renal Dialysis; Tryptophan; Tumor Necrosis Factor-alpha | 2017 |
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.
Topics: Animals; Cerebellum; Chromatography, Liquid; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Hippocampus; Kynurenic Acid; Kynurenine; Prefrontal Cortex; Rats; Tryptophan | 2017 |
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammation; Interleukin-10; Kynurenine; Linear Models; Male; Neopterin; ortho-Aminobenzoates; Pyridoxal Phosphate; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Young Adult | 2016 |
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Disease Models, Animal; Exploratory Behavior; Food Preferences; Hippocampus; Imipramine; Kynurenine; Kynurenine 3-Monooxygenase; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Sertraline; Sucrose; Swimming; Tryptophan | 2017 |
Tryptophan breakdown and cognition in bipolar disorder.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Sex Factors; Tryptophan | 2017 |
The tryptophan/kynurenine pathway, systemic inflammation, and long-term outcome after kidney transplantation.
Topics: Adult; Biomarkers; Chromatography, Liquid; Female; Graft Rejection; Graft Survival; Humans; Inflammation; Inflammation Mediators; Kidney Transplantation; Kynurenine; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Tandem Mass Spectrometry; Time Factors; Treatment Outcome; Tryptophan; Vascular Diseases | 2017 |
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Mice; Placenta; Pregnancy; Tryptophan | 2017 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2017 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult | 2019 |
Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenine; Male; Neurotransmitter Agents; Plasma; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tandem Mass Spectrometry; Toxoplasmosis; Tryptophan | 2019 |
Rickettsial pathogen uses arthropod tryptophan pathway metabolites to evade reactive oxygen species in tick cells.
Topics: Anaplasma phagocytophilum; Animals; Hemin; Host-Pathogen Interactions; Hydrolases; Ixodes; Kynurenic Acid; Kynurenine; NADP; Reactive Oxygen Species; RNA Interference; Transaminases; Tryptophan; Tryptophan Oxygenase; Up-Regulation; Xanthurenates | 2020 |
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oximes; Peptide Fragments; Quinolinic Acid; Sulfonamides; Tryptophan | 2020 |
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glaucoma; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Metabolic Networks and Pathways; Mice; Retina; Species Specificity; Tryptophan | 2021 |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Topics: Animals; Biogenic Amines; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Endothelial Cells; Humans; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Kynurenine; Mice; Nephritis; NF-kappa B; Psoriasis; Tryptophan | 2021 |