tryptophan and 3,5-bis(trifluoromethyl)benzyl n-acetyltryptophan

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Histidine; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Protein Conformation; Quinuclidines; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Transfection; Tryptophan

Topics: Acylation; Amino Acid Sequence; Animals; CHO Cells; Computer Simulation; Cricetinae; Dermatitis, Contact; Guinea Pigs; Humans; Male; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Recombinant Proteins; Structure-Activity Relationship; Substance P; Tryptophan

Topics: Animals; Biphenyl Compounds; Dipeptides; Drug Design; Humans; In Vitro Techniques; Indoles; Models, Chemical; Models, Molecular; Molecular Mimicry; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Solubility; Substance P; Tetrazoles; Tryptophan; Water

Topics: Animals; Animals, Newborn; Endothelium, Vascular; Hemodynamics; Intestines; Kinetics; Mesenteric Arteries; Muscle Denervation; Muscle Relaxation; Neurokinin-1 Receptor Antagonists; omega-N-Methylarginine; Oxygen Consumption; Substance P; Swine; Tryptophan; Vascular Resistance

Topics: Animals; Capillary Permeability; Dose-Response Relationship, Drug; Exudates and Transudates; Guinea Pigs; Lipopolysaccharides; Male; Nerve Endings; Neurokinin-1 Receptor Antagonists; Neutrophils; Parasympathetic Nervous System; Specific Pathogen-Free Organisms; Superoxide Dismutase; Tachykinins; Tryptophan

Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Base Sequence; Cell Division; Cell Line; Cell Survival; Cloning, Molecular; DNA Primers; DNA, Complementary; Hematopoiesis; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Protein Precursors; RNA, Messenger; Sequence Homology, Amino Acid; Tachykinins; Tryptophan

Topics: CD18 Antigens; Cell Adhesion; Epithelial Cells; Humans; In Vitro Techniques; Interleukin-1; Lipopolysaccharides; Lung; Macrophage-1 Antigen; Neurokinin-1 Receptor Antagonists; Neutrophils; RNA, Messenger; Serine Proteinase Inhibitors; Substance P; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Animals; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Ligands; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Structure; Neurokinin-1 Receptor Antagonists; Peptides; Protein Binding; Protein Conformation; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spectrophotometry, Infrared; Structure-Activity Relationship; Substrate Specificity; Thermodynamics; Tryptophan

Topics: Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Rats; Rats, Long-Evans; Sciatica; Substance P; Tryptophan

Topics: Animals; Aorta; Drug Interactions; Enzyme Inhibitors; Fish Venoms; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Substance P; Thiazines; Tryptophan; Vasodilation

Topics: Animals; Annexin A5; Apoptosis; Caspase Inhibitors; Caspases; Cell Size; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fetus; Humans; Immunohistochemistry; Kidney; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Prosencephalon; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tryptophan

Topics: Animals; Cell Division; Cell Survival; Female; Fetus; Flow Cytometry; Gene Expression; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Organ Culture Techniques; Pregnancy; Protein Precursors; RNA, Messenger; T-Lymphocytes; Tachykinins; Thymus Gland; Tryptophan

Topics: Animals; Autonomic Agents; Benzamides; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Synaptic Transmission; Tryptophan

Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Tryptophan

Topics: Animals; Capillary Permeability; Chlorpheniramine; Diphenhydramine; Evans Blue; Female; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Injections, Intradermal; Injections, Intravenous; Isothiuronium; Mast Cells; Mice; Mice, Mutant Strains; Piperidines; Receptors, Histamine H3; Skin; Thiourea; Tryptophan

Topics: Animals; Brain; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Female; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Neurokinin-1 Receptor Antagonists; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Swine; Tryptophan

Topics: 3-Mercaptopropionic Acid; Animals; Electroencephalography; Electromyography; Estrenes; Male; Microinjections; Neurokinin-1 Receptor Antagonists; Phosphodiesterase Inhibitors; Polysomnography; Preoptic Area; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Sleep; Substance P; Tryptophan; Wakefulness

Topics: Acetates; Animals; Catecholamines; Cell Compartmentation; Cell Nucleus; Cytoplasm; Endosomes; Hydralazine; Hypotension; Hypothalamo-Hypophyseal System; Hypothalamus, Anterior; Male; Microinjections; Microscopy, Confocal; Neurons; Oxytocin; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Transcription, Genetic; Tryptophan; Vasopressins

Topics: Animals; Cell Count; Drug Interactions; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Knockout; Morphine; Narcotics; Neurokinin-1 Receptor Antagonists; Pain Measurement; Protein Transport; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission; Time Factors; Touch; Tryptophan

Topics: Animals; Antigens; Cyproheptadine; Dibenzazepines; Dibenzoxepins; Dose-Response Relationship, Drug; Electroencephalography; Histamine H1 Antagonists; Hypersensitivity; Imidazoles; Male; Neurokinin-1 Receptor Antagonists; Olopatadine Hydrochloride; Rats; Rats, Wistar; Sneezing; Substance P; Tryptophan

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan

Topics: Alkaloids; Anilides; Animals; Benzodioxoles; Capsaicin; Cinnamates; Cricetinae; Enzyme Inhibitors; Esophagus; Female; Male; Mesocricetus; Mice; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Tachykinin; Species Specificity; TRPV Cation Channels; Tryptophan; Vagus Nerve

Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male; Muscle Contraction; omega-Conotoxins; Parathion; Physostigmine; Pirenzepine; Plethysmography, Whole Body; Substance P; Tetrodotoxin; Tryptophan

Topics: Anilides; Animals; Animals, Newborn; Bicuculline; Capsaicin; Cinnamates; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Immunohistochemistry; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin; TRPV Cation Channels; Tryptophan

Topics: Apoptosis; Blotting, Western; Cell Count; Cell Proliferation; Child, Preschool; Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Retinal Neoplasms; Retinoblastoma; Stereoisomerism; Substance P; Tryptophan; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Laryngeal Neoplasms; Mitosis; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan

Topics: Animals; Benzoates; Capsaicin; Clotrimazole; Cystic Fibrosis Transmembrane Conductance Regulator; Exocrine Glands; Irritants; Mice; Mice, Inbred CFTR; Mucus; Neurokinin-1 Receptor Antagonists; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Receptors, Neurokinin-1; Respiratory Mucosa; Substance P; Thiazolidines; Time Factors; Trachea; Tryptophan

Topics: Airway Resistance; Animals; Atropine; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Disease Models, Animal; Drug Combinations; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Hot Temperature; Humidity; Hyperthermia, Induced; Hyperventilation; Male; Neurons, Afferent; Piperidines; Receptors, Tachykinin; Specific Pathogen-Free Organisms; TRPV Cation Channels; Tryptophan

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Capsaicin; Central Nervous System Stimulants; Convulsants; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Membrane Potentials; Mice; Neurokinin-1 Receptor Antagonists; Neurons; Picrotoxin; Sensory System Agents; Sodium Channel Blockers; Strychnine; Substantia Gelatinosa; Tetrodotoxin; TRPV Cation Channels; Tryptophan

Topics: Animals; Blotting, Western; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Male; Motor Activity; Movement; Neurokinin-1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tachykinins; Tryptophan

Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Immunization; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nasal Provocation Tests; Neurokinin-1 Receptor Antagonists; Ovalbumin; Receptors, Neurokinin-1; Substance P; Tryptophan; Up-Regulation

Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation

Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Substance P; Tryptophan

Topics: Animals; Apoptosis; Cell Degranulation; Collagen; Disease Models, Animal; Heart Failure; In Situ Nick-End Labeling; Male; Mast Cells; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neurokinin A; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors; Tryptophan; Tumor Necrosis Factor-alpha; Ultrasonography; Ventricular Remodeling

Topics: Animals; Atropine; Electric Stimulation; Gene Expression; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Omasum; Organ Specificity; Piperidines; Protein Precursors; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Sheep; Tachykinins; Tryptophan

Topics: Analgesics, Opioid; Animals; Astrocytes; Biomarkers; CD11b Antigen; Hyperalgesia; Male; Microglia; Morphine; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome; Tryptophan; Tumor Necrosis Factor-alpha; Up-Regulation

Topics: Abomasum; Animals; Benzamides; Gastrointestinal Motility; Injections, Intravenous; Kinetics; Male; Muscle Contraction; Neurokinin A; Omasum; Piperidines; Receptors, Neurokinin-2; Rumen; Sheep; Substance P; Tachykinins; Tryptophan

Topics: Antineoplastic Agents; Apoptosis; Aprepitant; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Tryptophan; Tumor Cells, Cultured

Topics: Acute Disease; Animals; Colitis; Colon; Formaldehyde; Gene Expression; Lumbosacral Region; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nociception; Nociceptive Pain; Protein Transport; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tryptophan

Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Male; Medial Forebrain Bundle; Motor Activity; Oxidopamine; Parkinsonian Disorders; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Time Factors; Tryptophan; Tyrosine 3-Monooxygenase

Topics: Antineoplastic Agents; Aprepitant; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; MCF-7 Cells; Morpholines; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Substance P; Tryptophan

Topics: Animals; Arthritis, Experimental; Chronic Pain; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociception; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, Presynaptic; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Mechanical; Substance P; Tryptophan

Topics: Airway Resistance; Analysis of Variance; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Evans Blue; Formoterol Fumarate; Hot Temperature; Male; Ovalbumin; Piperidines; Rats; Respiratory Hypersensitivity; Trachea; Tryptophan

Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Survival; Gastrointestinal Neoplasms; Humans; Neurokinin-1 Receptor Antagonists; Tryptophan