tryptophan has been researched along with 1-methyltryptophan in 120 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.83) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (10.83) | 29.6817 |
| 2010's | 74 (61.67) | 24.3611 |
| 2020's | 32 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, SM; Zheng, X; Zou, H | 1 |
| Goldman, S; Henrottin, J; Laurent, S; Lemaire, C; Luxen, A; Plenevaux, A; Sapunaric, F; Van den Eynde, B; Zervosen, A | 1 |
| DeRose, EF; Duff, MR; Gabel, SA; Howell, EE; Krahn, JM; London, RE; Pedersen, LC | 1 |
| Chen, YX; Liu, SH; Sun, JX; Tian, W; Yang, Y; Zhang, WG; Zhao, WH | 1 |
| Anegon, I; Hill, M; Usal, C; Voisine, C; Zagani, R | 1 |
| Gui, S; Li, X; Wang, H | 1 |
| Konigsrainer, A; Lob, S; Opelz, G; Rammensee, HG; Schafer, R; Terness, P | 1 |
| Chakraborty, PK; Chugani, DC; Chugani, HT; Juhász, C; Lawrenson, L; Muzik, O; Sood, S | 1 |
| ELIEL, EL; SNYDER, HR | 1 |
| André, C; Castanon, N; Dantzer, R; Kelley, KW; Lawson, MA; Lestage, J; Moreau, M; O'Connor, JC | 1 |
| Däubener, W; Heseler, K; MacKenzie, CR; Schmidt, SK; Spekker, K | 1 |
| Ganapathy, V; Hatanaka, T; Itagaki, S; Karunakaran, S; Munn, DH; Prasad, PD; Thangaraju, M; Umapathy, NS | 1 |
| Colvin, BL; Mellor, AL; Salati, J; Sumpter, TL; Thomson, AW; Tokita, D | 1 |
| Andrews, C; Ayyoub, M; Beck, A; Cheney, R; Frederick, PJ; Lele, S; Liao, J; Matsuzaki, J; Mhawech-Fauceglia, P; Moysich, K; Odunsi, K; Old, LJ; Qian, F; Shrikant, P; Tario, JD; Valmori, D; Villella, J; Wallace, PK | 1 |
| Akimoto, H; Inaba, T; Ino, K; Kajiyama, H; Kikkawa, F; Nagasaka, T; Nawa, A; Shibata, K; Takikawa, O; Yamamoto, E | 1 |
| Nelson, BH | 1 |
| Chuck, RS; Gehlbach, PL; Park, CG; Park, CY; Yang, SH | 1 |
| Abu-Zahra, F; Ahmed, MB; Asfour, IA; El Kholy, NM; Habib, HZ; Hammouda, JA; Sallam, MM; Sallam, RM | 1 |
| Chen, YL; Huang, TT; Lai, MD; Lin, CC; Lin, CM; Weng, TY; Wu, CL; Yang, HJ; Yen, MC | 1 |
| Domanska, G; Drude, S; Fusch, G; Kiank, C; Otten, W; Schuett, C; Zeden, JP | 1 |
| Aluigi, M; Baccarani, M; Curti, A; De Cristofaro, R; Evangelisti, C; Lemoli, RM; Ocadlikova, D; Onofri, C; Ottaviani, E; Rutella, S; Salvestrini, V; Trabanelli, S | 1 |
| Amadeu, TP; da Costa Nery, JA; de Oliveira Fulco, T; de Souza Sales, J; Lara, FA; Pinheiro, RO; Sampaio, EP; Sarno, EN | 1 |
| Chernykh, ER; Leplina, OY; Ostanin, AA; Sakhno, LV; Tikhonova, MA; Tyrinova, TV | 1 |
| Cai, H; Cong, X; Fu, D; Hou, M; Li, D; Luo, Q; Lv, M; Lv, Z; Ma, Y; Yuan, X; Zhang, X | 1 |
| Mandik-Nayak, L; Pigott, E | 1 |
| Hara, T; Hoshi, M; Ito, H; Moriwaki, H; Nagano, J; Ninomiya, S; Ogawa, K; Saito, K; Sakai, H; Seishima, M; Shimizu, M; Tanaka, T; Tsurumi, H | 1 |
| Edwards, R; Kalinski, P; Lele, S; Liao, J; Odunsi, K; Qian, F; Shrikant, P; Villella, J | 1 |
| Corona, AW; Dantzer, R; Godbout, JP; Huang, Y; Kelley, KW; Lawson, M; Norden, DM; O'Connor, JC; Skendelas, JP | 1 |
| Barker, RN; Dahal, LN; Hall, LS; Ward, FJ | 1 |
| Ding, M; Feng, LL; Gao, JM; Ge, XL; Liu, XQ; Lu, K; Wang, X | 1 |
| Dantzer, R; Kelley, KW; Lawson, MA; McCusker, RH; O'Connor, JC; Parrott, JM | 1 |
| Albuquerque, RC; Campa, A; Clara, RO; Coimbra, JB; Júlio, AR; Maria-Engler, SS; Moreno, AC; Oliveira, EM | 1 |
| Curran, TA; Farrokhi, A; Ghahary, A; Jalili, RB | 1 |
| Antoniadi, G; Arampatzis, S; Eleftheriadis, T; Liakopoulos, V; Markala, D; Pissas, G; Stefanidis, I; Yiannaki, E | 1 |
| Garg, N; Haeryfar, SM; Jevnikar, AM; Meilleur, CE; Rytelewski, M; Schell, TD; Sharif, S; Singh, B; Szabo, PA; Yekta, MA | 1 |
| Cai, L; Gao, L; He, Q; Liu, Y; Ren, Z; Xiao, L; Xie, W; Yu, Y | 1 |
| Fox, JM; Mellor, AL; Sage, LK; Tompkins, SM; Tripp, RA | 1 |
| DuHadaway, JB; Gilmour, S; Mandik-Nayak, L; Muller, AJ; Pigott, E; Prendergast, GC | 1 |
| Fox, JM; Johnson, S; Poore, S; Sage, LK; Tompkins, SM; Tripp, RA | 1 |
| Choi, EY; Lee, SE; Lim, JY; Min, CK; Park, G | 1 |
| Le, V; Lin, S; Liu, J; Que, Z; Tian, J; Zhang, A; Zhang, L; Zheng, Y | 1 |
| Antoniadi, G; Eleftheriadis, T; Liakopoulos, V; Pissas, G; Spanoulis, A; Stefanidis, I | 1 |
| Baan, CC; Betjes, MG; Demmers, MW; Hoogduijn, MJ; Korevaar, SS; Roemeling-van Rhijn, M; Rowshani, AT; van den Bosch, TP; Weimar, W | 1 |
| Ando, T; Arioka, Y; Ito, H; Saito, K; Seishima, M | 1 |
| Antonia, S; Dees, EC; Han, H; Harvey, RD; Ismail-Khan, R; Jackson, E; Link, C; Minton, S; Neuger, T; Soliman, HH; Sullivan, DM; Vahanian, NN | 1 |
| Garg, R; Landi, A; Schulz, S; van Drunen Littel-van den Hurk, S; Wilson, JA | 1 |
| Chrisman, IM; Dameron, LS; Hixon, BP; Kolawole, AO; Smirnov, VV | 1 |
| Alvisi, C; Badulli, C; Bernardo, ME; Betti, E; Bozzi, V; Cangemi, GC; Cervio, M; Ciccocioppo, R; Corazza, GR; Dionigi, P; Gallia, A; Gobbi, P; Gurrado, A; Kruzliak, P; Martinetti, M; Monti, M; Pecci, A; Picone, C; Visai, L | 1 |
| Asada, M; Eguchi, H; Kawamura, T; Lo, PC; Maeda, A; Matsuura, R; Miyagawa, S; Nakahata, K; Okuyama, H; Sakai, R; Yamanaka, K | 1 |
| Goto, N; Hara, T; Ito, H; Kochi, T; Kubota, M; Mabuchi, R; Moriwaki, H; Nagano, J; Nakamura, N; Ohno, T; Saito, K; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H | 1 |
| Camañes, G; García-Agustín, P; González-Bosch, C; Scalschi, L; Vicedo, B | 1 |
| da Cunha Bianchi, PK; Gebrim, LH; Kfoury, JR; Salvadori, ML; Silva, RS | 1 |
| Fujinaga, M; Hatori, A; Higuchi, M; Kumata, K; Maeda, J; Nengaki, N; Shimoda, Y; Suhara, T; Wakizaka, H; Wang, F; Xie, L; Yamasaki, T; Yui, J; Zhang, MR; Zhang, Y | 1 |
| Hanihara, M; Kawataki, T; Kinouchi, H; Mitsuka, K; Nakao, A; Oh-Oka, K | 1 |
| Brandão, ML; Carabelli, B; Cunha, JM; Cunha, TM; da Silva Dias, IC; de Carvalho, MC; de Morais, H; Ferraz, AC; Ishii, DK; Rizzo de Souza, LE; Zanata, SM; Zanoveli, JM | 1 |
| Domanska, G; Kanitz, E; Otten, W; Scheuch, E; Seidlitz, A; Tuchscherer, A; Tuchscherer, M; Weitschies, W; Wirthgen, E | 1 |
| Antonia, SJ; Chiappori, AA; Han, HS; Ismail-Khan, R; Khambati, F; Link, C; Lush, R; Mautino, M; Minton, SE; Neuger, A; Noyes, D; Roberts, JD; Soliman, HH; Streicher, H; Sullivan, DM; Vahanian, NN | 1 |
| Bieback, K; Ho, AD; Hong, J; Hueckelhoven, A; Kleist, C; Schmitt, A; Schmitt, M; Tabarkiewicz, J; Wang, L; Wuchter, P | 1 |
| Antoniadi, G; Antoniadis, N; Eleftheriadis, T; Liakopoulos, V; Pissas, G; Sounidaki, M; Stefanidis, I; Tsogka, K | 1 |
| Cordeiro, RC; da Silva Araújo, T; de Freitas Lima, R; de Jesus Souza Machado, M; Freitas de Lucena, D; Isabelle de Góis Queiroz, A; Macêdo, D; Maes, M; Maia Chaves Filho, AJ; Monte, AS | 1 |
| Barone, PR; Belzung, C; Callebert, J; Guillemin, GJ; Laugeray, A; Launay, JM; Mutlu, O | 1 |
| Li, D; Li, M; Liu, Y; Mei, J; Tang, L; Wei, C; Zhu, X | 1 |
| Brochez, L; Chevolet, I; Kruse, V | 1 |
| Arsenijevic, A; Djonov, V; Dolicanin, Z; Gazdic, M; Lukic, ML; Milosavljevic, N; Nurkovic, J; Simovic Markovic, B; Volarevic, V | 1 |
| Ando, T; Hara, A; Ito, H; Kanbe, A; Moriwaki, H; Ogiso, H; Seishima, M; Shimizu, M | 1 |
| Albejante, MC; Amaral, TA; Bach, EE; Brito, RBO; Camacho, CP; Dalboni, MA; Dellê, H; Malta, CS; Matheus, LHG; Matos, YST; Rodrigues, GGC; Santana, AC; Simão, GM | 1 |
| Calleja, P; Espuelas, S; Irache, JM; Martínez-Oharriz, C; Zandueta, C | 1 |
| Chen, S; Dong, G; Fang, K; Liu, J; Sheng, C; Wang, W; Wu, S; Wu, Y | 1 |
| Chang, CH; Jiang, J; Jiang, W; Liao, YP; Liu, X; Lu, J; Meng, H; Nel, AE; Salazar, F; Sun, B; Wang, X; Wu, AM | 1 |
| Suolang, Y; Tang, Y; Zhang, Y; Zhao, L; Zhou, D | 1 |
| Schmidt, C | 1 |
| Abu Eid, R; Ahmad, S; Berrong, Z; Hammond, S; Janik, JE; Khleif, SN; Matevosyan, A; Mkrtichyan, M; Mohamed, E; Okoev, G; Shrimali, R; Webb, M | 1 |
| Bianchi, A; Coda Zabetta, G; Fallarini, S; Griglio, A; Massarotti, A; Pirali, T; Schmid, R; Serafini, M; Sorba, G; Torre, E | 1 |
| Bang, H; Bozec, A; Engdahl, C; Figueiredo, C; Luo, Y; Schett, G | 1 |
| Ding, Y; Du, Q; Hu, R; Liu, X; Zhang, X; Zhou, W | 1 |
| Alahdal, M; Liang, J; Tang, T; Xing, Y | 1 |
| Smith, D; Yentz, S | 1 |
| El Osta, B; Floyd, M; Tang, SC | 1 |
| Brenmoehl, J; Domanska, G; Günther, J; Kanitz, E; Ohde, D; Otten, W; Scheuch, E; Seidlitz, A; Tuchscherer, A; Tuchscherer, M; Weitschies, W; Wirthgen, E | 1 |
| James, CD; Juhász, C; Kennedy, E; Lesniak, MS; Lukas, RV; Stupp, R; Wainwright, DA | 1 |
| Chen, J; Huang, Y; Li, J; Li, S; Lu, B; Ma, X; Moharil, P; Sun, J; Wan, Z; Xie, W; Xu, J; Xu, P; Zhu, J | 1 |
| Andreev, D; Bäuerle, T; Boon, L; Bozec, A; Ellmann, S; Kindermann, M; Peckert, K; Rauh, M; Royzman, D; Schett, G; Steinkasserer, A; Stich, L; Zinser, E | 1 |
| Ahn, MS; Ahn, SG; Eom, YW; Kim, JY; Lee, JH; Lee, JW; Lee, SH; Oh, JE; Park, SW; Rhee, KJ; Son, JW; Yoo, BS; Yoon, J; Youn, YJ | 1 |
| Aldinucci, D; Borghese, C; Casagrande, N | 1 |
| Dréno, B; Khammari, A; Knol, AC; Le Naour, S; Pandolfino, MC | 1 |
| Guo, G; Sun, L; Xu, H; Yang, L | 1 |
| Chen, X; Fu, Y; Gong, T; Han, X; Hu, Y; John Kao, W; Wang, M; Xu, Y; Zhang, ZR | 1 |
| Gao, S; Gao, Y; Gong, C; Han, Z; Li, G; Qiang, L; Tai, Z; Tian, J | 1 |
| Anegon, I; Frungieri, MB; Gualdoni, GS; Guazzone, VA; Hill, M; Höcht, C; Jacobo, PV; Lustig, L; Matzkin, ME; Pérez, CV; Sobarzo, CM | 1 |
| Firat, E; Gaedicke, S; Guffart, E; Niedermann, G; Watanabe, T | 1 |
| Cheng, J; Li, Z; Liu, M; Ma, B; Min, W; Wang, H; Wang, L; Yao, W; Zeng, X; Zhang, R | 1 |
| Erhardt, S; Goiny, M; Imbeault, S; Liu, X | 1 |
| Chu, CE; Grossfeld, GD; Meng, MV; Porten, SP | 1 |
| Jeong, JH; Jung, TW; Kim, HC; Nabeshima, T; Nah, SY; Nguyen, BT; Phan, DH; Saito, K; Sharma, N; Shin, EJ; Tran, HQ | 1 |
| Chen, C; Du, W; Fan, C; Jiang, X; Liu, Y; Sun, P; Wu, J; Yan, C; Zhang, J; Zhang, R; Zhang, S; Zhang, X | 1 |
| Almquist, DR; Block, MS; Bryce, AH; DeLeon, TT; Dronca, RS; Joseph, RW; Kipp, BR; Kosiorek, HE; Kottschade, LA; Langlais, BT; Mangold, A; Markovic, SN; McWilliams, RR; Rumilla, KM; Seetharam, M; Sekulic, A; Voss, JS; Winters, JL | 1 |
| Gao, S; Hu, Z; Lu, W; Xu, J; Zheng, B | 1 |
| Araújo, G; Carabelli, B; de Souza, LER; Delattre, AM; Ferraz, AC; Machado, RB; Suchecki, D; Waltrick, APF; Zanata, SM; Zanoveli, JM | 1 |
| Adams, J; Brincks, EL; Jaipuri, FA; Kumar, S; Link, C; Marcinowicz, A; Mautino, MR; Potturi, H; Vahanian, N; Van Allen, C; Waldo, JP; Zhuang, H | 1 |
| Ahlstedt, J; Ceberg, C; Konradsson, E; Redebrandt, HN | 1 |
| Du, L; Duan, Z; Guo, L; Kuang, C; Liang, H; Shi, L; Takikawa, O; Xing, Z; Yang, Q; Zhang, S | 1 |
| Campa, A; Consolaro, MEL; da Costa Souza, P; Faião-Flores, F; Felipe-Silva, A; Maria-Engler, SS; Migliorini, S; Oliveira, EA; Sandri, S; Tiago, M; Vazquez, VL; Watanabe, LRM | 1 |
| Feng, X; He, X; Li, Y; Qi, D; Shen, X; Xia, X; Zeng, Z; Zhou, Z; Zhu, C | 1 |
| Boeira, SP; Cattelan Souza, L; de Brito, MLO; de Gomes, MG; Fabbro, LD; Goes, ATR; Jesse, CR; Machado, FR; Nogueira, CW; Prigol, M | 1 |
| Brito, RBO; Camacho, CP; Dalmazzo, SV; de Almeida, RJ; Dellê, H; Matheus, LHG; Pereira, LA | 1 |
| Feng, Q; Ma, H; Mi, J; Qin, Q | 1 |
| Chang, CH; Chiang, M; Ji, Y; Jiang, J; Khazaieli, M; Li, J; Liao, YP; Liu, Q; Liu, X; Mei, KC; Melano, B; Meng, H; Nel, AE; Telesca, D; Wang, X; Xia, T; Zhang, X | 1 |
| Camañes, G; García-Agustín, P; González-Hernández, AI; Llorens, E; Scalschi, L; Vicedo, B | 1 |
| Danciu, O; Dillon, P; Gilman, P; Han, H; Ibrahim, NK; Ismail-Khan, R; Kennedy, E; Link, C; Mariotti, V; Melin, S; Montero, AJ; Poklepovic, A; Schuster, S; Smith, C; Soliman, H; Tang, SC; Tennant, L; Vahanian, N | 1 |
| Hou, Z; Jiang, Y; Luan, Y; Ren, X; Wang, N; Zhou, Y | 1 |
| Čepcová, D; Deelman, LE; Kema, IP; Klimas, J; Sandovici, M; Šišková, K; Vavrincová-Yaghi, D; Vavrinec, P | 1 |
| Bansal, Y; Bhandari, R; Kuhad, A; Kumar, B; Saroj, P; Singh, R; Sodhi, RK | 1 |
| Huang, P; Liu, J; Song, H; Su, Q; Wang, C; Wang, W; Zhang, C; Zhang, J; Zhang, Y | 1 |
| Brincks, EL; Drabick, J; Grossmann, KF; Kennedy, EP; Kolhe, R; Link, CJ; McWilliams, RR; Milhem, M; Munn, D; Pacholczyk, R; Rixe, O; Rossi, GR; Sadek, R; Shaheen, MF; Shen, SS; Smith, CM; Tennant, LL; Vahanian, NN; Yu, J; Zakharia, Y | 1 |
| Cao, T; Li, X; Lin, B; Liu, C; Luo, S; Shi, J; Wang, S; Zhang, X; Zheng, T; Zhou, M | 1 |
| Dehpour, AR; Faghir-Ghanesefat, H; Guillemin, GJ; Mani, AR; Rashidian, A; Shayesteh, S; Tavangar, SM | 1 |
| Bilir, C; Guney Eskiler, G | 1 |
| Fan, D; Fang, J; Feng, C; He, L; Liang, W; Qin, X; Wang, Q | 1 |
| Dang, C; Guo, J; Jia, H; Li, J; Li, M; Li, R; Li, X; Li, Y; Liu, Z; Wang, S; Zhang, Y; Zhao, T; Zhu, G | 1 |
| Piyu, J; Song, J; Yi, X; Zang, X | 1 |
4 review(s) available for tryptophan and 1-methyltryptophan
| Article | Year |
|---|---|
The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Enzyme Inhibitors; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Neoplasms; Oximes; Sulfonamides; T-Lymphocytes; Tryptophan | 2017 |
Indoleamine 2,3-Dioxygenase (IDO) Inhibition as a Strategy to Augment Cancer Immunotherapy.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Neoplasms; Oximes; Sulfonamides; Tryptophan; Tumor Microenvironment | 2018 |
Formation of the Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It.
Topics: Antibodies, Monoclonal, Humanized; Chemokines; Cytokines; Hodgkin Disease; Immunosuppressive Agents; Killer Cells, Natural; Maraviroc; Nivolumab; Prognosis; Receptors, CCR5; Reed-Sternberg Cells; T-Lymphocytes; Trabectedin; Tryptophan; Tumor Escape; Tumor Microenvironment; Zoledronic Acid | 2019 |
Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer.
Topics: Acetamides; Administration, Intravesical; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Neoplasm Invasiveness; Oximes; Quinolines; Salvage Therapy; Sulfonamides; Treatment Outcome; Tryptophan; Tryptophan Oxygenase; Urinary Bladder Neoplasms | 2020 |
4 trial(s) available for tryptophan and 1-methyltryptophan
| Article | Year |
|---|---|
A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors.
Topics: Administration, Intravenous; Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Administration Schedule; Drug Monitoring; Female; Florida; Humans; Immunologic Factors; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasms; Taxoids; Time Factors; Treatment Outcome; Tryptophan | 2014 |
A phase I study of indoximod in patients with advanced malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Tryptophan; Young Adult | 2016 |
Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer: A Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Middle Aged; Prospective Studies; Taxoids; Tryptophan | 2021 |
Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Immunotherapy; Male; Melanoma; Middle Aged; Tryptophan | 2021 |
112 other study(ies) available for tryptophan and 1-methyltryptophan
| Article | Year |
|---|---|
Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus ( section sign).
Topics: Aspergillus fumigatus; Dimethylallyltranstransferase; Dipeptides; Molecular Structure; Substrate Specificity; Tryptophan | 2009 |
N (1)-Fluoroalkyltryptophan Analogues: Synthesis and in vitro Study as Potential Substrates for Indoleamine 2,3-Dioxygenase.
Topics: | 2015 |
The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallography, X-Ray; Drug Design; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Tetrahydrofolate Dehydrogenase | 2020 |
Indoleamine 2, 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan.
Topics: Adolescent; Adult; Animals; Child; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukemia L1210; Leukemia, Biphenotypic, Acute; Leukemia, Monocytic, Acute; Male; Mice; Mice, Inbred DBA; Middle Aged; Tryptophan; Young Adult | 2007 |
Nitric oxide and indoleamine 2,3-dioxygenase mediate CTLA4Ig-induced survival in heart allografts in rats.
Topics: Abatacept; Animals; Dendritic Cells; Enzyme Inhibitors; Graft Survival; Heart Transplantation; Immunoconjugates; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Transplantation, Homologous; Tryptophan | 2007 |
Effect of Kidney-replenishing herb on the indoleamine 2,3-dioxygenase of human syncytiotrophoblasts cultured in vitro and the balance of helper T-cell cytokines.
Topics: Animals; Coculture Techniques; Codonopsis; Culture Media, Conditioned; Cytokines; Embryo Culture Techniques; Enzyme Inhibitors; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Kynurenine; Plants, Medicinal; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; T-Lymphocytes, Helper-Inducer; Trophoblasts; Tryptophan | 2007 |
Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells.
Topics: Cytokines; Dendritic Cells; Gene Expression Regulation, Enzymologic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; RNA, Small Interfering; Stereoisomerism; Transfection; Tryptophan | 2008 |
Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy.
Topics: Adolescent; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Corpus Striatum; Drug Resistance; Epilepsy; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neostriatum; Neurosurgical Procedures; Positron-Emission Tomography; Radiopharmaceuticals; Serotonin; Tryptophan | 2008 |
A synthesis of 1-methyltryptophan.
Topics: Tryptophan | 1948 |
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cytokinins; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Hindlimb Suspension; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Minocycline; Motor Activity; Swimming; Time Factors; Tryptophan | 2009 |
Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gamma-induced tryptophan degradation.
Topics: Animals; Cell Line; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-1; Lung; Simplexvirus; Staphylococcus aureus; Toxoplasma; Tryptophan; Tumor Necrosis Factor-alpha | 2008 |
Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.
Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Antineoplastic Agents; Biological Transport, Active; Cell Line; Cell Line, Tumor; Humans; Large Neutral Amino Acid-Transporter 1; Mice; Oocytes; Plasma Membrane Neurotransmitter Transport Proteins; Tryptophan; Xenopus laevis | 2008 |
Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B7-2 Antigen; Cell Proliferation; CTLA-4 Antigen; Dendritic Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inducible T-Cell Co-Stimulator Ligand; Inducible T-Cell Co-Stimulator Protein; Interferon-gamma; Interleukin-10; Interleukin-4; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Proteins; RNA, Small Interfering; T-Lymphocytes; Tryptophan | 2009 |
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer.
Topics: Cell Division; Cell Line; Epithelial Cells; Female; Flow Cytometry; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Ovarian Neoplasms; Stereoisomerism; T-Lymphocytes; Transfection; Tryptophan | 2009 |
Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Progression; Drug Synergism; Female; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Transfection; Tryptophan; Xenograft Model Antitumor Assays | 2009 |
IDO and outcomes in ovarian cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; CD8-Positive T-Lymphocytes; Drug Synergism; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocytes, Tumor-Infiltrating; Ovarian Neoplasms; Paclitaxel; Prognosis; Tryptophan | 2009 |
The role of indoleamine 2,3-dioxygenase in retinal pigment epithelial cell-mediated immune modulation.
Topics: Animals; B7-1 Antigen; B7-2 Antigen; Cells, Cultured; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Lymphocyte Culture Test, Mixed; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Retinal Pigment Epithelium; Tryptophan | 2010 |
Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells.
Topics: Adult; Antibiotics, Antineoplastic; Blast Crisis; Case-Control Studies; Doxorubicin; Drug Therapy, Combination; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukemia, Myeloid, Acute; Male; Middle Aged; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tryptophan; Tumor Cells, Cultured | 2011 |
A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity.
Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Drug Therapy, Combination; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Liver Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Mice, Inbred NOD; Neoplasms, Experimental; Nicotinamide Phosphoribosyltransferase; Piperidines; Tryptophan; Urinary Bladder Neoplasms | 2010 |
Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans.
Topics: Adult; Aged; Aged, 80 and over; Animals; Female; Humans; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Male; Mice; Mice, Inbred BALB C; Middle Aged; Mifepristone; Serotonin; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha | 2010 |
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells.
Topics: Acute Disease; Adult; Biocatalysis; Blotting, Western; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Humans; Immunophenotyping; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leukemia, Myeloid; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Tryptophan; Tumor Cells, Cultured | 2010 |
The role of indoleamine 2, 3-dioxygenase in lepromatous leprosy immunosuppression.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; B7-2 Antigen; Blotting, Western; Cells, Cultured; Dendritic Cells; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immune Tolerance; Immunoblotting; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Leprosy, Lepromatous; Leprosy, Tuberculoid; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophages; Monocytes; Mycobacterium leprae; Polymerase Chain Reaction; Skin; Tryptophan | 2011 |
Contribution of dehydroepiandrosterone sulfate and progesterone to in vitro regulation of tolerogenic activity of IFN-α-induced dendritic cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; B7-H1 Antigen; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dendritic Cells; Dinoprostone; Humans; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indomethacin; Interferon-alpha; Interleukin-3 Receptor alpha Subunit; Progesterone; Tryptophan | 2011 |
Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenine; Liver; Male; Rats; Tryptophan; Tumor Necrosis Factor-alpha | 2012 |
Addition of an indoleamine 2,3,-dioxygenase inhibitor to B cell-depletion therapy blocks autoreactive B cell activation and recurrence of arthritis in K/BxN mice.
Topics: Animals; Arthritis, Experimental; Autoantibodies; B-Lymphocytes; Cell Differentiation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocyte Depletion; Mice; Mice, Transgenic; Secondary Prevention; Tryptophan | 2012 |
Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Tryptophan | 2012 |
Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation.
Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Stereoisomerism; Tryptophan | 2012 |
Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.
Topics: Animals; Behavior, Animal; Brain; CX3C Chemokine Receptor 1; Depression; Hydroxyindoleacetic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; Mice; Microglia; Motor Activity; Receptors, Cytokine; Receptors, HIV; Serotonin; Tryptophan | 2013 |
Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia.
Topics: Abatacept; Adoptive Transfer; Anemia, Hemolytic, Autoimmune; Animals; Antibodies, Monoclonal; Autoantibodies; CTLA-4 Antigen; Disease Models, Animal; Erythrocytes; Immunization; Immunoconjugates; Indoleamine-Pyrrole 2,3,-Dioxygenase; Isoantibodies; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Self Tolerance; Species Specificity; Spleen; Tryptophan | 2013 |
Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration.
Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Female; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-2 Receptor alpha Subunit; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Male; Mice; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Tryptophan; Up-Regulation; Young Adult | 2014 |
Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Exploratory Behavior; Food Preferences; Indoleamine-Pyrrole 2,3,-Dioxygenase; Injections, Intraventricular; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Sucrose; Time Factors; Tryptophan; Up-Regulation | 2013 |
The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells.
Topics: Cell Line; Cell Line, Tumor; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Real-Time Polymerase Chain Reaction; Skin; Tryptophan | 2013 |
IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Coculture Techniques; CTLA-4 Antigen; Fibroblasts; Flow Cytometry; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Skin; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tryptophan | 2014 |
Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.
Topics: Adult; Citric Acid Cycle; Enzyme Activation; Glucose; Glucose Transporter Type 1; Glycolysis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukocytes, Mononuclear; Lymphocyte Culture Test, Mixed; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Protein Serine-Threonine Kinases; T-Lymphocyte Subsets; TOR Serine-Threonine Kinases; Tryptophan | 2013 |
Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral; CD4 Antigens; CD8-Positive T-Lymphocytes; Forkhead Transcription Factors; Gene Expression; Immune Tolerance; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza A virus; Interleukin-2 Receptor alpha Subunit; Kynurenine; Lymphocyte Activation; Mice; Mice, Knockout; T-Lymphocytes, Regulatory; Tryptophan | 2014 |
Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy.
Topics: Animals; Chromatography, Liquid; Cytokines; Depression; Disease Models, Animal; Epilepsy, Temporal Lobe; Food Preferences; Gene Expression Regulation; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lithium Chloride; Male; Mass Spectrometry; Minocycline; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors; Tryptophan | 2014 |
Indoleamine 2,3-dioxygenase (IDO) activity during the primary immune response to influenza infection modifies the memory T cell response to influenza challenge.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Enzyme Inhibitors; Female; Immunologic Factors; Immunologic Memory; Indoleamine-Pyrrole 2,3,-Dioxygenase; Influenza A virus; Lung; Mice, Inbred C57BL; Orthomyxoviridae Infections; Treatment Outcome; Tryptophan | 2014 |
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase | 2014 |
Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection.
Topics: Animals; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Influenza A Virus, H3N2 Subtype; Lung; Macrophage Activation; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Nuclear Proteins; Orthomyxoviridae Infections; Receptors, Pattern Recognition; Time Factors; Tryptophan; Ubiquitin-Protein Ligases | 2014 |
Inhibition of indoleamine 2,3-dioxygenase by stereoisomers of 1-methyl tryptophan in an experimental graft-versus-tumor model.
Topics: Allografts; Animals; Bone Marrow Transplantation; Cell Line, Tumor; Cytotoxicity, Immunologic; Drug Evaluation, Preclinical; Enzyme Induction; Graft vs Tumor Effect; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Leukocyte Transfusion; Lymph Nodes; Lymphocyte Culture Test, Mixed; Mastocytoma; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Radiation Chimera; Spleen; Stereoisomerism; Time Factors; Transplantation Chimera; Tryptophan | 2014 |
Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Coculture Techniques; Disease Progression; Drug Screening Assays, Antitumor; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred C57BL; Neoplasm Transplantation; Paclitaxel; Saponins; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Triterpenes; Tryptophan; Tumor Burden; Tumor Escape | 2014 |
Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.
Topics: Adult; Apoptosis Regulatory Proteins; Benzothiazoles; Carrier Proteins; Cell Proliferation; Cells, Cultured; Enzyme Activation; Female; Glucose; Glucose Transporter Type 1; Glucosephosphate Dehydrogenase; Glycolysis; Healthy Volunteers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intracellular Signaling Peptides and Proteins; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mechanistic Target of Rapamycin Complex 1; Middle Aged; Mitochondrial Proteins; Molecular Chaperones; Multiprotein Complexes; Phosphoric Monoester Hydrolases; T-Lymphocytes; Toluene; TOR Serine-Threonine Kinases; Tryptophan; Tumor Suppressor Protein p53 | 2014 |
Human renal tubular epithelial cells suppress alloreactive T cell proliferation.
Topics: Antibodies, Blocking; Apoptosis; B7-H1 Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Communication; Cell Proliferation; Cells, Cultured; Coculture Techniques; Enzyme Activation; Epithelial Cells; Focal Adhesions; Gene Expression Regulation; Graft Rejection; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intercellular Adhesion Molecule-1; Isoantigens; Kidney Transplantation; Kidney Tubules; Tryptophan | 2015 |
Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model.
Topics: Aminoquinolines; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Imiquimod; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymph Nodes; Lymphocytes, Tumor-Infiltrating; Membrane Glycoproteins; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction; Th1 Cells; Thymoma; Thyroid Neoplasms; Time Factors; Toll-Like Receptor 7; Tryptophan; Tumor Burden | 2015 |
Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.
Topics: Adult; Aged; Case-Control Studies; Chemokines; Cytokines; Dendritic Cells; Female; Gene Expression; Gene Expression Regulation; Genotype; Hepacivirus; Hepatitis C; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Leukocyte Count; Male; Middle Aged; Monocytes; RNA, Messenger; Tryptophan; Viral Load; Virus Replication; Young Adult | 2015 |
Catalytic activity of human indoleamine 2,3-dioxygenase (hIDO1) at low oxygen.
Topics: Binding Sites; Carbolines; Catalysis; Escherichia coli; Harmine; Humans; Immunosuppressive Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Oxygen; Protein Binding; Substrate Specificity; Tryptophan | 2015 |
Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Surface; Apoptosis; Bone Marrow Cells; Cell Proliferation; Cell Survival; Cells, Cultured; Coculture Techniques; Crohn Disease; Cytokines; Female; HLA-G Antigens; Humans; Immunophenotyping; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Male; Mesenchymal Stem Cells; Middle Aged; RNA Interference; RNA, Small Interfering; T-Lymphocytes; Time-Lapse Imaging; Tryptophan; Young Adult | 2015 |
Monocytic MDSCs regulate macrophage-mediated xenogenic cytotoxicity.
Topics: Cells, Cultured; Cytotoxicity, Immunologic; Graft Rejection; Humans; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophage Activation; Macrophages; Myeloid Cells; Nitric Oxide; Transplantation, Heterologous; Tryptophan | 2015 |
Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
Topics: Animals; Cyclophosphamide; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasms, Experimental; T-Lymphocytes, Regulatory; Tryptophan | 2015 |
An untargeted global metabolomic analysis reveals the biochemical changes underlying basal resistance and priming in Solanum lycopersicum, and identifies 1-methyltryptophan as a metabolite involved in plant responses to Botrytis cinerea and Pseudomonas sy
Topics: Botrytis; Disease Resistance; Gene Expression Regulation, Plant; Metabolomics; Pseudomonas syringae; Solanum lycopersicum; Tryptophan | 2015 |
Effect of the association of 1-methyl-DL-tryptophan with paclitaxel on the expression of indoleamine 2,3-dioxygenase in cultured cancer cells from patients with breast cancer.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Paclitaxel; Tryptophan; Tumor Cells, Cultured | 2015 |
Development of 1-N-(11)C-Methyl-L- and -D-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan.
Topics: Animals; Antineoplastic Agents; Carbon Radioisotopes; Drug Stability; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tissue Distribution; Tryptophan; X-Ray Microtomography | 2015 |
Synergistic antitumor effect with indoleamine 2,3-dioxygenase inhibition and temozolomide in a murine glioma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Female; Gene Knockdown Techniques; Glioma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; RNA, Messenger; Survival Analysis; Temozolomide; Treatment Outcome; Tryptophan; Tumor Burden | 2016 |
Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Cytokines; Depression; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluoxetine; Hippocampus; Ibuprofen; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Minocycline; Molecular Targeted Therapy; Motor Activity; Norepinephrine; Rats, Wistar; Serotonin; Swimming; Tryptophan; Weight Gain | 2016 |
Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model.
Topics: Animals; Enzyme Inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Injections, Subcutaneous; Models, Animal; Swine; Time Factors; Tissue Distribution; Tryptophan | 2016 |
Indoleamine 2,3-dioxygenase mediates inhibition of virus-specific CD8(+) T cell proliferation by human mesenchymal stromal cells.
Topics: CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytomegalovirus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mesenchymal Stem Cells; Tryptophan | 2016 |
Indoleamine 2,3-dioxygenase, by degrading L-tryptophan, enhances carnitine palmitoyltransferase I activity and fatty acid oxidation, and exerts fatty acid-dependent effects in human alloreactive CD4+ T-cells.
Topics: Adult; Apoptosis; Blotting, Western; Carnitine O-Palmitoyltransferase; CD4-Positive T-Lymphocytes; Cells, Cultured; eIF-2 Kinase; Fatty Acids; Female; Forkhead Transcription Factors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Nuclear Receptor Subfamily 1, Group F, Member 3; Oxidation-Reduction; Phosphorylation; Protein Serine-Threonine Kinases; T-Lymphocytes, Regulatory; Tryptophan | 2016 |
Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs.
Topics: Animals; Antipsychotic Agents; Brain; Disease Models, Animal; Immunologic Factors; Immunomodulation; Interleukin-4; Interleukin-6; Ketamine; Male; Melatonin; Mice; Neuroimmunomodulation; Random Allocation; Risperidone; Schizophrenia; Schizophrenic Psychology; Tryptophan | 2017 |
Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Chronic Disease; Cytokines; Depression; Fluoxetine; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Mice, Inbred BALB C; Signal Transduction; Stress, Psychological; Time Factors; Tryptophan | 2016 |
1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.
Topics: Adult; Animals; Cell Differentiation; Disease Progression; Endometriosis; Estrogens; Female; Humans; Immunosuppression Therapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lectins, C-Type; Lymphocyte Count; Mannose Receptor; Mannose-Binding Lectins; Mice, Inbred C57BL; Middle Aged; Peritoneum; Receptors, Cell Surface; Signal Transduction; T-Lymphocytes, Regulatory; Tryptophan; Up-Regulation; Young Adult | 2016 |
Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells.
Topics: Animals; Carbon Tetrachloride; CD8-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Forkhead Transcription Factors; Galactosylceramides; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Liver Failure, Acute; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Neutrophils; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan | 2017 |
The Inhibition of Indoleamine 2,3-Dioxygenase Accelerates Early Liver Regeneration in Mice After Partial Hepatectomy.
Topics: Animals; Hepatectomy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Liver Diseases; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Tryptophan | 2017 |
Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition.
Topics: Animals; Dogs; Epithelial-Mesenchymal Transition; Fibrosis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney Diseases; Madin Darby Canine Kidney Cells; Male; Rats; Rats, Wistar; Transforming Growth Factor beta1; Tryptophan | 2017 |
A combination of nanosystems for the delivery of cancer chemoimmunotherapeutic combinations: 1-Methyltryptophan nanocrystals and paclitaxel nanoparticles.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Mice, Inbred C57BL; Nanoparticles; Paclitaxel; Particle Size; Solubility; Tryptophan; X-Ray Diffraction | 2017 |
Discovery of IDO1 and DNA dual targeting antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Melphalan; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Tryptophan | 2017 |
Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression.
Topics: Adaptive Immunity; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Drug Carriers; Feasibility Studies; Female; Forkhead Transcription Factors; Humans; Immune Tolerance; Immunity, Innate; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Nanoparticles; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Phospholipids; Porosity; Prodrugs; Silicon Dioxide; T-Lymphocytes, Cytotoxic; Tissue Distribution; Tryptophan; Xenograft Model Antitumor Assays | 2017 |
Bifidobacteria alleviate experimentally induced colitis by upregulating indoleamine 2, 3-dioxygenase expression.
Topics: Animals; Bifidobacterium; Colitis; Colonic Diseases; Disease Models, Animal; Female; Forkhead Transcription Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred BALB C; Probiotics; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tryptophan; Up-Regulation | 2018 |
The benefits of immunotherapy combinations.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Biomarkers, Tumor; Cancer Vaccines; Cell Cycle Checkpoints; Clinical Trials as Topic; Combined Modality Therapy; CTLA-4 Antigen; Drug Costs; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ipilimumab; Lung Neoplasms; Male; Melanoma; Nivolumab; Oncolytic Virotherapy; Patient Selection; Precision Medicine; Programmed Cell Death 1 Receptor; Survival Analysis; T-Lymphocytes; Tryptophan; Tumor Escape | 2017 |
Antigen-Specific Antitumor Responses Induced by OX40 Agonist Are Enhanced by the IDO Inhibitor Indoximod.
Topics: Animals; Antigens, Differentiation; Cancer Vaccines; Epitopes, T-Lymphocyte; Female; Humans; Immunotherapy; Lung Neoplasms; Mice; Mice, Inbred C57BL; Tryptophan; Tryptophan Oxygenase; Xenograft Model Antitumor Assays | 2018 |
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.
Topics: Catalytic Domain; Cell Line, Tumor; Drug Discovery; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Molecular Docking Simulation; Molecular Structure; Oximes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tryptophan | 2018 |
Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner.
Topics: Abatacept; Adalimumab; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Cells, Cultured; Cytokines; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophages; Monocytes; Rheumatoid Factor; Tryptophan | 2018 |
1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cdc20 Proteins; Cell Cycle; Cell Proliferation; Colitis; Colonic Neoplasms; Enzyme Inhibitors; Homeodomain Proteins; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitosis; Tryptophan; Tumor Cells, Cultured | 2018 |
1-Methyl-D-tryptophan Reduces Tumor CD133
Topics: AC133 Antigen; Adenocarcinoma; Animals; Apoptosis; beta Catenin; Carcinogenesis; Caspase 3; Cell Line, Tumor; Enzyme Activation; Female; Lymphocytes; Mice; Mice, Inbred C57BL; Necrosis; Neoplastic Stem Cells; Pancreatic Neoplasms; Signal Transduction; STAT3 Transcription Factor; STAT4 Transcription Factor; Transcription Factor RelA; Tryptophan; Wnt Proteins | 2018 |
First Report of Parkinsonism Associated With Indoximod, an Immune-Modulating Agent.
Topics: Female; Humans; Middle Aged; Parkinsonian Disorders; Tryptophan | 2018 |
Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.
Topics: Animals; Cytokines; Fibroblasts; Immunity; Inflammation; Kynurenine; Lipopolysaccharides; Lung; Metabolic Networks and Pathways; Metabolome; RNA, Messenger; Swine; Tryptophan | 2018 |
Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod.
Topics: Adult; Brain; Brain Neoplasms; Female; Glioblastoma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Tryptophan | 2019 |
Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Drug Carriers; Female; Immunotherapy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Prodrugs; Tryptophan | 2019 |
Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner.
Topics: Animals; Antibodies, Blocking; Antigens, CD; Arthritis, Experimental; CD83 Antigen; Cytokines; Female; Immunoglobulins; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Joints; Membrane Glycoproteins; Mice; Signal Transduction; Solubility; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tryptophan | 2019 |
Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis.
Topics: Autophagy; Cell Cycle Checkpoints; Fibrosis; Gene Expression Regulation; Humans; Interferon-gamma; Muscle Proteins; Myocardial Infarction; Myocardium; Myofibroblasts; Signal Transduction; Tryptophan | 2019 |
Effect of Indoleamine 2,3 Dioxygenase Inhibitor on the Cytotoxic Activity of Tumour-infiltrating Lymphocytes.
Topics: Antineoplastic Agents; Cell Line, Tumor; Coculture Techniques; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymphocytes, Tumor-Infiltrating; Melanoma; Skin Neoplasms; Tryptophan | 2019 |
IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis.
Topics: Animals; Coculture Techniques; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Electrocardiography; Enterovirus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; L-Lactate Dehydrogenase; Macrophages; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Myocarditis; Myocytes, Cardiac; Signal Transduction; Transfection; Tryptophan; Up-Regulation | 2019 |
Hierarchical assembly of hyaluronan coated albumin nanoparticles for pancreatic cancer chemoimmunotherapy.
Topics: Albumins; Animals; Cell Line, Tumor; Coated Materials, Biocompatible; Female; Humans; Hyaluronic Acid; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Nanoparticles; Neoplasm Proteins; Pancreatic Neoplasms; Pentacyclic Triterpenes; Triterpenes; Tryptophan; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Dual-Blockade Immune Checkpoint for Breast Cancer Treatment Based on a Tumor-Penetrating Peptide Assembling Nanoparticle.
Topics: Animals; B7-H1 Antigen; Cell Line, Tumor; Cell-Penetrating Peptides; Enzyme Inhibitors; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasm Proteins; RNA, Small Interfering; Tryptophan | 2019 |
Role of indoleamine 2,3-dioxygenase in testicular immune-privilege.
Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Epididymis; Immune Privilege; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymph Nodes; Male; Orchitis; Rats; Rats, Wistar; Sertoli Cells; Severity of Illness Index; Testis; Tryptophan; Tryptophan Oxygenase | 2019 |
Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chemoradiotherapy; Female; Killer Cells, Natural; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Programmed Cell Death 1 Receptor; Radiation Dose Hypofractionation; Survival Rate; Tryptophan | 2020 |
IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion.
Topics: Animals; B7-H1 Antigen; Carcinoma, Lewis Lung; Combined Modality Therapy; Dendritic Cells; Drug Resistance, Neoplasm; Flow Cytometry; Galectins; Gene Expression Regulation, Neoplastic; Hepatitis A Virus Cellular Receptor 2; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ligands; Programmed Cell Death 1 Receptor; Receptors, Immunologic; T-Lymphocytes, Regulatory; Tryptophan | 2020 |
Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Cognitive Dysfunction; Enzyme Inhibitors; Indoles; Inflammation; Kynurenine; Lipopolysaccharides; Male; Mice; Tryptophan | 2020 |
Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase.
Topics: Amphetamine; Animals; Antimanic Agents; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lithium Chloride; Locomotion; Male; Mania; Meloxicam; Mice, Inbred C57BL; Prefrontal Cortex; Signal Transduction; Tryptophan | 2020 |
Eliciting an immune hot tumor niche with biomimetic drug-based multi-functional nanohybrids augments immune checkpoint blockade-based breast cancer therapy.
Topics: Animals; Biomimetic Materials; Breast Neoplasms; Female; Humans; MCF-7 Cells; Mice, Inbred BALB C; Nanoparticles; Oxaliplatin; Tryptophan; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; CTLA-4 Antigen; Cyclin-Dependent Kinase Inhibitor p16; Female; Humans; Immunotherapy; Ipilimumab; Male; Melanoma; Middle Aged; Mutation; Nivolumab; Programmed Cell Death 1 Receptor; Survival Analysis; Tryptophan; Tumor Suppressor Protein p53 | 2020 |
An albumin-bound drug conjugate of paclitaxel and indoleamine-2,3-dioxygenase inhibitor for enhanced cancer chemo-immunotherapy.
Topics: Albumins; Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Drug Compounding; Drug Synergism; Female; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Melanoma, Experimental; Mice; Nanoparticles; Paclitaxel; Particle Size; T-Lymphocytes, Regulatory; Treatment Outcome; Tryptophan; Xenograft Model Antitumor Assays | 2020 |
Fish-oil supplementation decreases Indoleamine-2,3-Dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Depression; Dietary Supplements; Fatty Acids, Omega-3; Fish Oils; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lipopolysaccharides; Male; Minocycline; Rats; Rats, Wistar; Serotonin; Tryptophan | 2020 |
Discovery of indoximod prodrugs and characterization of clinical candidate NLG802.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biological Availability; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Compounding; Drug Screening Assays, Antitumor; Haplorhini; Humans; Intestinal Absorption; Mice; Molecular Conformation; Neoplasms; Prodrugs; Rats; Tryptophan | 2020 |
Increased effect of two-fraction radiotherapy in conjunction with IDO1 inhibition in experimental glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression; Glioblastoma; Indoleamine-Pyrrole 2,3,-Dioxygenase; Rats; Rats, Inbred F344; Tryptophan; Tumor Microenvironment | 2020 |
Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Neurons; Rats; Receptors, Aryl Hydrocarbon; Tryptophan | 2020 |
Indoleamine 2,3-dioxygenase in melanoma progression and BRAF inhibitor resistance.
Topics: Antineoplastic Agents; Cell Line, Tumor; Databases, Genetic; Drug Resistance, Neoplasm; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Melanoma; Molecular Targeted Therapy; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Tryptophan; Vemurafenib | 2020 |
Highly uniform self-assembled microspheres from single macromolecule self-recognition for enhanced cancer immunotherapy.
Topics: Animals; Antibodies; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Synergism; Enzyme Inhibitors; Female; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Melanoma; Mice, Inbred C57BL; Microspheres; Polyethylene Glycols; Programmed Cell Death 1 Receptor; Tryptophan | 2020 |
Involvement of kynurenine pathway in depressive-like behaviour induced by nandrolone decanoate in mice.
Topics: Anabolic Agents; Animals; Behavior, Animal; Corpus Striatum; Depression; Dose-Response Relationship, Drug; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred C57BL; Nandrolone Decanoate; Prefrontal Cortex; Tryptophan | 2020 |
1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
Topics: Aged; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Receptors, Aryl Hydrocarbon; Signal Transduction; Tryptophan; Urinary Bladder Neoplasms | 2020 |
1-MT inhibits the invasion of CBP-resistant ovarian cancer cells via down-regulating IDO expression and re-activating immune cells function.
Topics: Antineoplastic Agents; Carboplatin; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Killer Cells, Natural; Ovarian Neoplasms; Tryptophan | 2020 |
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
Topics: Animals; Cell Line, Tumor; Immunotherapy; Liposomes; Mice; Mitoxantrone; Neoplasms; Prodrugs; Tryptophan | 2020 |
1-Methyltryptophan Treatment Increases Defense-Related Proteins in the Apoplast of Tomato Plants.
Topics: Gene Expression Regulation, Plant; Plant Diseases; Proteomics; Pseudomonas syringae; Solanum lycopersicum; Tryptophan | 2021 |
Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation.
Topics: Animals; Antineoplastic Agents; Axitinib; Chlorophyllides; Dendritic Cells; Enzyme Inhibitors; Female; Immunity; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Light; Mice, Inbred C57BL; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protein Kinase Inhibitors; Tryptophan; Tumor Microenvironment | 2021 |
The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition.
Topics: Animals; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Diseases; Lectins, C-Type; Mice; NIH 3T3 Cells; NK Cell Lectin-Like Receptor Subfamily K; Reperfusion Injury; Signal Transduction; T-Lymphocytes; THP-1 Cells; Toll-Like Receptor 4; Transforming Growth Factor beta; Tryptophan | 2021 |
IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred BALB C; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinsonian Disorders; Tryptophan | 2021 |
Co-delivery of anionic epitope/CpG vaccine and IDO inhibitor by self-assembled cationic liposomes for combination melanoma immunotherapy.
Topics: Animals; Anions; Cancer Vaccines; Cations; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; CpG Islands; Dendritic Cells; Epitopes; Immunotherapy; Lipids; Liposomes; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanostructures; Polymers; Survival Rate; Tryptophan | 2021 |
STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinogenesis; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Female; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Membrane Proteins; Mice; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Neoplasm Transplantation; Programmed Cell Death 1 Receptor; Tryptophan | 2021 |
1-Methyl tryptophan, an indoleamine 2,3-dioxygenase inhibitor, attenuates cardiac and hepatic dysfunction in rats with biliary cirrhosis.
Topics: Animals; Liver Cirrhosis, Biliary; Rats; Tryptophan | 2021 |
The efficacy of indoximod upon stimulation with pro-inflammatory cytokines in triple-negative breast cancer cells.
Topics: B7-H1 Antigen; Cell Line, Tumor; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interferon-gamma; Treatment Outcome; Triple Negative Breast Neoplasms; Tryptophan; Tumor Necrosis Factor-alpha | 2021 |
Injectable Micelle-Incorporated Hydrogels for the Localized Chemo-Immunotherapy of Breast Tumors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chondroitin Sulfates; Delayed-Action Preparations; Deoxycytidine; Enzyme Inhibitors; Female; Gemcitabine; Hydrogels; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred BALB C; Micelles; Neoplasm Metastasis; Poloxamer; Tryptophan; Tumor Microenvironment | 2021 |
D-MT prompts the anti-tumor effect of oxaliplatin by inhibiting IDO expression in a mouse model of colon cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxaliplatin; Tryptophan | 2021 |
Polymeric indoximod based prodrug nanoparticles with doxorubicin entrapment for inducing immunogenic cell death and improving the immunotherapy of breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Female; Humans; Immunogenic Cell Death; Immunologic Factors; Immunotherapy; Mice; Nanoparticles; Polymers; Prodrugs; Tryptophan; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2022 |