Page last updated: 2024-09-02

tryptoline and tadalafil

tryptoline has been researched along with tadalafil in 2 studies

Compound Research Comparison

Studies (tryptoline)	Trials (tryptoline)	Recent Studies (post-2010) (tryptoline)	Studies (tadalafil)	Trials (tadalafil)	Recent Studies (post-2010) (tadalafil)
222	1	69	1,742	392	1,089

Protein Interaction Comparison

Protein	Taxonomy	tadalafil (IC50)
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0012
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0012
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0012
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0012
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	3.0704
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	Homo sapiens (human)	2.928
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens (human)	3.0704
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.5153
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Bos taurus (cattle)	5.1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	Bos taurus (cattle)	4.05
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	Homo sapiens (human)	2.928
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	Bos taurus (cattle)	5.1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Homo sapiens (human)	2.928
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Bos taurus (cattle)	5.1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	Bos taurus (cattle)	5.1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	9.2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	Homo sapiens (human)	2.928
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	Homo sapiens (human)	2.507
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Homo sapiens (human)	3.0704
Synaptic vesicular amine transporter	Rattus norvegicus (Norway rat)	0.012
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	4.6028
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Homo sapiens (human)	9.2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	4.6028
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	3.0704
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Homo sapiens (human)	2.928
cGMP-specific 3',5'-cyclic phosphodiesterase	Bos taurus (cattle)	0.0075
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	Bos taurus (cattle)	5.1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Homo sapiens (human)	0.8575
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	Homo sapiens (human)	3.0704
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens (human)	3.0704

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Authors

Authors	Studies
Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R	1
Abadi, AH; Ahmed, NS; Gary, BD; Laufer, S; Piazza, GA; Tinsley, HN	1

Other Studies

2 other study(ies) available for tryptoline and tadalafil

Article	Year
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. Journal of medicinal chemistry, 2021, 06-24, Volume: 64, Issue:12 Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; HEK293 Cells; Humans; Molecular Structure; Orphan Nuclear Receptors; Propranolol; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship	2021
Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors. Archiv der Pharmazie, 2011, Volume: 344, Issue:3 Topics: Carbolines; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Humans; Inhibitory Concentration 50; Phosphodiesterase 5 Inhibitors; Structure-Activity Relationship; Tadalafil	2011

Article

Year

Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.

Journal of medicinal chemistry, 2021, 06-24, Volume: 64, Issue:12

Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; HEK293 Cells; Humans; Molecular Structure; Orphan Nuclear Receptors; Propranolol; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship

2021

Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

Archiv der Pharmazie, 2011, Volume: 344, Issue:3

Topics: Carbolines; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Humans; Inhibitory Concentration 50; Phosphodiesterase 5 Inhibitors; Structure-Activity Relationship; Tadalafil

2011