Page last updated: 2024-09-02

tryptoline and norharman

tryptoline has been researched along with norharman in 10 studies

Compound Research Comparison

Studies
(tryptoline)
Trials
(tryptoline)
Recent Studies (post-2010)
(tryptoline)
Studies
(norharman)
Trials
(norharman)
Recent Studies (post-2010) (norharman)
2221693642153

Protein Interaction Comparison

ProteinTaxonomytryptoline (IC50)norharman (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)1.6209
Translocator proteinRattus norvegicus (Norway rat)1.6218
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)1.6218
Tryptophan 2,3-dioxygenaseHomo sapiens (human)1.2
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)1.6218
GABA theta subunitRattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)1.6218
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)1.6209
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)1.6218

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's1 (10.00)18.2507
2000's3 (30.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Bourke, CA; Carrigan, MJ; Dixon, RJ1
Oderfeld-Nowak, B; Rommelspacher, H; Skup, M1
Galisteo, J; Herraiz, T1
Asensio, VJ; Esteban, S; García-Sevilla, JA; Miralles, A; Moranta, D; Sastre-Coll, A1
Chen, X; Cromer, BA; Lynch, JW1
Alarifi, A; Chetna, J; Kamal, A; Manasa, KL; Sathish, M; Srinivasulu, V; Tangella, Y1
Cabrerizo, FM; Denofrio, MP; Erra-Balsells, R; García Einschlag, FS; Rasse-Suriani, FAO; Schmidt De León, T; Villarruel, F1
Baumeister, TUH; Buaya, A; Grabe, V; Kaftan, F; Pohnert, G; Svatoš, A; Thines, M; Vallet, M1

Other Studies

10 other study(ies) available for tryptoline and norharman

ArticleYear
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Upper motor neurone effects in sheep of some beta-carboline alkaloids identified in zygophyllaceous plants.
    Australian veterinary journal, 1990, Volume: 67, Issue:7

    Topics: Alkaloids; Animals; Carbolines; Female; Harmaline; Harmine; Locomotion; Motor Neurons; Plants, Toxic; Sheep

1990
In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline acetyltransferase and on the muscarinic receptor binding of the rat brain.
    Journal of neurochemistry, 1983, Volume: 41, Issue:1

    Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Carbolines; Cattle; Choline O-Acetyltransferase; Erythrocytes; Harmaline; Harmine; Indoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Structure-Activity Relationship

1983
Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.
    Free radical research, 2002, Volume: 36, Issue:8

    Topics: Antioxidants; Benzothiazoles; Carbolines; Cations; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Food Analysis; Free Radicals; Gas Chromatography-Mass Spectrometry; Harmine; Indicators and Reagents; Models, Chemical; Sulfonic Acids; Time Factors

2002
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.
    European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3

    Topics: Animals; Benzofurans; Binding, Competitive; Brain; Carbolines; Cerebral Cortex; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Harmine; Hippocampus; Imidazoles; Imidazoline Receptors; Liver; Male; Monoamine Oxidase; Morphine; Morphine Dependence; Naloxone; Norepinephrine; Picolinic Acids; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Substance Withdrawal Syndrome; Thiazoles; Tritium; Tyrosine 3-Monooxygenase

2005
Molecular determinants of beta-carboline inhibition of the glycine receptor.
    Journal of neurochemistry, 2009, Volume: 110, Issue:5

    Topics: Binding Sites; Carbolines; Cell Line; Harmine; Humans; Mutagenesis, Site-Directed; Mutation; Protein Structure, Secondary; Protein Subunits; Receptors, Glycine; Recombinant Proteins

2009
PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I.
    Organic & biomolecular chemistry, 2015, Aug-28, Volume: 13, Issue:32

    Topics: Acetates; Carbolines; Decarboxylation; Harmine; Iodobenzenes; Molecular Structure; Oxidation-Reduction

2015
Light-induced full aromatization and hydroxylation of 7-methoxy-1-methyl-3,4-dihydro-2H-pyrido[3,4-b]indole alkaloid: Oxygen partial pressure as a key modulator of the photoproducts distribution.
    Journal of photochemistry and photobiology. B, Biology, 2019, Volume: 199

    Topics: Alkaloids; Carbolines; Harmaline; Harmine; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxylation; Indoles; Light; Multivariate Analysis; Oxygen; Partial Pressure; Photochemical Processes; Reactive Oxygen Species; Singlet Oxygen; Structure-Activity Relationship

2019
The oomycete Lagenisma coscinodisci hijacks host alkaloid synthesis during infection of a marine diatom.
    Nature communications, 2019, 10-30, Volume: 10, Issue:1

    Topics: Alkaloids; Carbolines; Cell Division; Diatoms; Host-Parasite Interactions; Infections; Metabolome; Microscopy, Confocal; Oomycetes; Principal Component Analysis; Single-Cell Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2019