trypanothione has been researched along with glutathionylspermidine in 21 studies
| Studies (trypanothione) | Trials (trypanothione) | Recent Studies (post-2010) (trypanothione) | Studies (glutathionylspermidine) | Trials (glutathionylspermidine) | Recent Studies (post-2010) (glutathionylspermidine) |
|---|---|---|---|---|---|
| 187 | 0 | 47 | 35 | 0 | 8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fairlamb, AH | 1 |
| Cerami, A; Fairlamb, AH; Henderson, GB | 1 |
| Jacoby, EM; Krauth-Siegel, RL; Schirmer, RH | 1 |
| Ariyanayagam, MR; Borges, A; Fairlamb, AH; Smith, K | 1 |
| Agosin, M; Maya, JD; Morello, A; Opazo, E; Repetto, Y | 1 |
| Hernández, E; Hurtado, G; Iturbe, A; Ondarza, RN; Tamayo, EM | 1 |
| Ballatori, N; Wang, W | 1 |
| Ariyanayagam, MR; Fairlamb, AH | 1 |
| Ariyanayagam, MR; Davies, AJ; Hunter, KJ; Mastri, C; Thorborn, DE | 1 |
| Bruns, K; Budde, H; Flohé, L; Guerrero, SA; Hecht, HJ; Hofmann, B; Kalisz, HM; Menge, U; Montemartini, M; Nogoceke, E; Steinert, P; Wissing, JB | 1 |
| Budde, H; Flohé, L; Hecht, HJ; Krumme, D; Menge, U; Ohlenschläger, O; Ross, A; Wissing, J; Wray, V | 1 |
| Comini, MA; Flohé, L; Guerrero, SA; Haile, S; Lünsdorf, H; Menge, U | 1 |
| Dirdjaja, N; Krauth-Siegel, RL; Melchers, J; Ruppert, T | 1 |
| Buchholz, K; Comini, MA; Gromer, S; Krauth-Siegel, RL; Schirmer, RH; Wissenbach, D | 1 |
| Chen, S; Coward, JK; Fairlamb, AH; Oza, SL; Wyllie, S | 1 |
| Fairlamb, AH; Oza, SL; Patterson, S; Spinks, D; Thompson, S; Wyllie, S | 1 |
| Berndt, C; Ceylan, S; Dirdjaja, N; Krauth-Siegel, RL; Seidel, V; Ziebart, N | 1 |
| Cappel, D; Flohé, L; Jäger, T; Koch, O; Nocker, M; Selzer, PM; Sotriffer, CA | 1 |
| Bakker, BM; Haanstra, JR; Krauth-Siegel, RL; Leroux, AE | 1 |
| Benítez, D; Castro, H; Comini, MA; Flohé, L; Gomes-Alves, AG; Jaeger, T; Passos, J; Sousa, AF; Stuhlmann, F; Tomás, AM | 1 |
| Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A | 1 |
1 review(s) available for trypanothione and glutathionylspermidine
| Article | Year |
|---|---|
Endogenous glutathione conjugates: occurrence and biological functions.
Topics: Animals; Biological Transport; Cells; Free Radicals; Glutathione; Humans; Spermidine; Sulfides | 1998 |
20 other study(ies) available for trypanothione and glutathionylspermidine
| Article | Year |
|---|---|
The role of glutathionylspermidine and trypanothione in regulation of intracellular spermidine levels during growth of Crithidia fasciculata.
Topics: Animals; Crithidia; Glutathione; Hydrogen-Ion Concentration; Putrescine; Spermidine; Sulfhydryl Compounds | 1988 |
The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata.
Topics: Animals; Antiprotozoal Agents; Crithidia; Glutathione; Spermidine | 1986 |
Trypanothione and N1-glutathionylspermidine: isolation and determination.
Topics: Animals; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Disulfides; Dithionitrobenzoic Acid; Glutathione; Indicators and Reagents; Microchemistry; NADH, NADPH Oxidoreductases; NADP; Sensitivity and Specificity; Spectrophotometry; Spermidine; Trypanosoma | 1995 |
Glutathionylspermidine metabolism in Escherichia coli.
Topics: Amino Acid Sequence; Base Sequence; Disulfides; DNA Primers; Escherichia coli; Glutathione; Glutathione Disulfide; Glutathione Reductase; Kinetics; Models, Biological; Molecular Sequence Data; Oxidation-Reduction; Polymerase Chain Reaction; Recombinant Proteins; Restriction Mapping; Spermidine | 1995 |
Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cycloheximide; Glutathione; Nifurtimox; Nitroimidazoles; Species Specificity; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 1996 |
Isolation and purification of glutathionyl-spermidine and trypanothione from Entamoeba histolytica.
Topics: Animals; Entamoeba histolytica; Glutathione; Spermidine; Trypanosoma | 1997 |
Entamoeba histolytica lacks trypanothione metabolism.
Topics: Animals; Entamoeba histolytica; Glutathione; Leishmania donovani; NADH, NADPH Oxidoreductases; Species Specificity; Spermidine; Sulfhydryl Compounds; Trypanosoma cruzi | 1999 |
Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.
Topics: Animals; Biogenic Polyamines; Cadaverine; Culture Media; Eflornithine; Glutathione; Methylhistidines; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine; Sulfhydryl Compounds; Tritium; Trypanosoma; Trypanosoma cruzi | 2001 |
Structures of tryparedoxins revealing interaction with trypanothione.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Crithidia fasciculata; Crystallography, X-Ray; Cysteine; Glutathione; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Sequence Homology, Amino Acid; Serine; Spermidine; Thioredoxins | 2001 |
NMR studies of the interaction of tryparedoxin with redox-inactive substrate homologues.
Topics: Animals; Computer Simulation; Crithidia; Crystallography, X-Ray; Enzyme Activation; Glutathione; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Oxidoreductases; Protozoan Proteins; Solutions; Spermidine; Substrate Specificity; Thioredoxins | 2003 |
Validation of Trypanosoma brucei trypanothione synthetase as drug target.
Topics: Amide Synthases; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Survival; Down-Regulation; Glutathione; Hydrogen Peroxide; Oxidants; Oxidative Stress; RNA Interference; Spermidine; Suppression, Genetic; Trypanosoma brucei brucei | 2004 |
Glutathionylation of trypanosomal thiol redox proteins.
Topics: Amino Acid Sequence; Animals; Cysteine; Disulfides; Glutathione; Insulin; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spermidine; Sulfhydryl Compounds; Trypanosoma | 2007 |
Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products.
Topics: Animals; Antioxidants; Catalysis; Dihydrolipoamide Dehydrogenase; Glutathione; Methylene Blue; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Reactive Oxygen Species; Spermidine; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma | 2008 |
ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.
Topics: Adenosine Triphosphate; Amide Synthases; Animals; Catalysis; Crithidia fasciculata; Enzyme Inhibitors; Eukaryota; Glutathione; Kinetics; Ligases; Molecular Mimicry; Peptides; Phosphinic Acids; Spermidine | 2008 |
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Topics: Amide Synthases; Amidohydrolases; Animals; Enzyme Inhibitors; Gene Knockout Techniques; Glutathione; Mice; Oxidative Stress; Polyamines; Protozoan Proteins; Spermidine; Substrate Specificity; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2009 |
The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism.
Topics: Animals; Catalytic Domain; Cytochromes c; Glutaredoxins; Glutathione; Mitochondrial Membranes; Mitochondrial Proteins; Oxidation-Reduction; Protozoan Proteins; Spermidine; Thioredoxins; Trypanosoma brucei brucei | 2010 |
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase.
Topics: Amide Synthases; Computational Biology; Glutathione; Molecular Dynamics Simulation; Protein Binding; Spermidine | 2013 |
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling.
Topics: Adenosine Triphosphatases; Amide Synthases; Amidohydrolases; Biocatalysis; Buffers; Computer Simulation; Cytosol; Enzyme Assays; Glutathione; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Models, Molecular; Spermidine; Substrate Specificity; Temperature; Time Factors; Trypanosoma brucei brucei | 2013 |
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.
Topics: Amide Synthases; Animals; Antiprotozoal Agents; Gene Knockout Techniques; Glutathione; Leishmania infantum; Leishmaniasis, Visceral; Male; Mice; Mice, Inbred BALB C; Spermidine | 2014 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glutathione; Humans; Imidazoles; Nitroimidazoles; Polyamines; Spermidine; Thiophenes; Trypanosoma cruzi; User-Computer Interface | 2016 |