troxacitabine has been researched along with topotecan in 5 studies
Studies (troxacitabine) | Trials (troxacitabine) | Recent Studies (post-2010) (troxacitabine) | Studies (topotecan) | Trials (topotecan) | Recent Studies (post-2010) (topotecan) |
---|---|---|---|---|---|
72 | 17 | 2 | 2,392 | 626 | 792 |
Protein | Taxonomy | troxacitabine (IC50) | topotecan (IC50) |
---|---|---|---|
Cytochrome P450 3A4 | Homo sapiens (human) | 1.5211 | |
DNA topoisomerase 1 | Homo sapiens (human) | 0.8525 | |
DNA topoisomerase 2-alpha | Homo sapiens (human) | 0.605 | |
DNA topoisomerase 2-beta | Homo sapiens (human) | 0.605 | |
Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 0.06 | |
Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | 8.6 | |
Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.3 | |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.17 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Larson, RA | 1 |
Giles, FJ | 1 |
Cortes, JE; Douer, D; Estey, EH; Faderl, S; Garcia-Manero, G; Giles, FJ; Jeha, SS; Kantarjian, HM; Koller, CA; Levine, AM; O'Brien, SM; Thomas, DA | 1 |
Baker, SD; Chatelut, E; Mathijssen, RH; Rowinsky, EK; Sparreboom, A; Verweij, J; Wolff, AC | 1 |
2 review(s) available for troxacitabine and topotecan
Article | Year |
---|---|
New agents for induction and postremission therapy of acute myeloid leukemia.
Topics: Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cytosine; Dioxolanes; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Topotecan | 2001 |
Troxacitabine-based therapy of refractory leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Cytosine; Dioxolanes; Humans; Idarubicin; Leukemia; Remission Induction; Topotecan | 2002 |
1 trial(s) available for troxacitabine and topotecan
Article | Year |
---|---|
Randomized phase I/II study of troxacitabine combined with cytarabine, idarubicin, or topotecan in patients with refractory myeloid leukemias.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Cytosine; Dioxolanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Idarubicin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Topotecan; Treatment Outcome | 2003 |
2 other study(ies) available for troxacitabine and topotecan
Article | Year |
---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Evaluation of alternate size descriptors for dose calculation of anticancer drugs in the obese.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Body Mass Index; Body Size; Body Surface Area; Body Weight; Camptothecin; Carboplatin; Cisplatin; Cytosine; Dioxolanes; Docetaxel; Doxorubicin; Humans; Irinotecan; Metabolic Clearance Rate; Obesity; Paclitaxel; Taxoids; Topotecan | 2007 |